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Kunihiro Shinagawa

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Chemicals & Drugs

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Katsuhiko Omoe; Wataru Nunomura; Hidehito Kato; Zhong-Juan Li; Osamu Igarashi; Minako Araake; Keigo Sano; Hisaya K Ono; Yohei Abe; Dong-Liang Hu; Akio Nakane; Hiroshi Kiyono; Yuichi Takakuwa; Kunihiro Shinagawa; Takehiko Uchiyama; Ken'ichi Imanishi
High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells.
Kunihiro Shinagawa
[Foodborne disease outbreaks reported in Japan, 1952-2009--outbreaks of microbial foodborne disease].
Dong-Liang Hu; Katsuhiko Omoe; Hiroshi Sashinami; Kunihiro Shinagawa; Akio Nakane
Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEAD227A, protects against enterotoxin-induced emesis in house musk shrews.

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All Publications

2010: Katsuhiko Omoe; Wataru Nunomura; Hidehito Kato; Zhong-Juan Li; Osamu Igarashi; Minako Araake; Keigo Sano; Hisaya K Ono; Yohei Abe; Dong-Liang Hu; Akio Nakane; Hiroshi Kiyono; Yuichi Takakuwa; Kunihiro Shinagawa; Takehiko Uchiyama; Ken'ichi Imanishi
High affinity of interaction between superantigen and T cell receptor Vbeta molecules induces a high level and prolonged expansion of superantigen-reactive CD4+ T cells.
The Journal of biological chemistry 2010;285(40):30427-35.
2010: Kunihiro Shinagawa
[Foodborne disease outbreaks reported in Japan, 1952-2009--outbreaks of microbial foodborne disease].
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 2010;51(6):274-8.
2009: Dong-Liang Hu; Katsuhiko Omoe; Hiroshi Sashinami; Kunihiro Shinagawa; Akio Nakane
Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEAD227A, protects against enterotoxin-induced emesis in house musk shrews.
The Journal of infectious diseases 2009;199(3):302-10.
2008: Hisaya K Ono; Katsuhiko Omoe; Ken'ichi Imanishi; Yoshihiro Iwakabe; Dong-Liang Hu; Hidehito Kato; Naoyuki Saito; Akio Nakane; Takehiko Uchiyama; Kunihiro Shinagawa
Identification and characterization of two novel staphylococcal enterotoxins, types S and T.
Infection and immunity 2008;76(11):4999-5005.
2007: Dong-Liang Hu; Gang Zhu; Fumiaki Mori; Katsuhiko Omoe; Motohiro Okada; Koichi Wakabayashi; Sunao Kaneko; Kunihiro Shinagawa; Akio Nakane
Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is downregulated by cannabinoid receptor 1.
Cellular microbiology 2007;9(9):2267-77.
2006: Dong-Liang Hu; Katsuhiko Omoe; Kouji Narita; Jing-Chun Cui; Kunihiro Shinagawa; Akio Nakane
Intranasal vaccination with a double mutant of staphylococcal enterotoxin C provides protection against Staphylococcus aureus infection.
Microbes and infection / Institut Pasteur 2006;8(14-15):2841-8.
2005: Katsuhiko Omoe; Ken'ichi Imanishi; Dong-Liang Hu; Hidehito Kato; Yoshitaku Fugane; Yohei Abe; Shoji Hamaoka; Yutaka Watanabe; Akio Nakane; Takehiko Uchiyama; Kunihiro Shinagawa
Characterization of novel staphylococcal enterotoxin-like toxin type P.
Infection and immunity 2005;73(9):5540-6.
2005: Dong-Liang Hu; Sechiko Suga; Katsuhiko Omoe; Yoshinao Abe; Kunihiro Shinagawa; Makoto Wakui; Akio Nakane
Staphylococcal enterotoxin A modulates intracellular Ca2+ signal pathway in human intestinal epithelial cells.
FEBS letters 2005;579(20):4407-12.
2005: Katsuhiko Omoe; Dong-Liang Hu; Hiromi Takahashi-Omoe; Akio Nakane; Kunihiro Shinagawa
Comprehensive analysis of classical and newly described staphylococcal superantigenic toxin genes in Staphylococcus aureus isolates.
FEMS microbiology letters 2005;246(2):191-8.
2005: Dong-Liang Hu; Jing-Chun Cui; Katsuhiko Omoe; Hiroshi Sashinami; Yuichi Yokomizo; Kunihiro Shinagawa; Akio Nakane
A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection.
Infection and immunity 2005;73(1):174-80.
2004: Katsuhiko Omoe; Ken'ichi Imanishi; Dong-Liang Hu; Hidehito Kato; Hiromi Takahashi-Omoe; Akio Nakane; Takehiko Uchiyama; Kunihiro Shinagawa
Biological properties of staphylococcal enterotoxin-like toxin type R.
Infection and immunity 2004;72(6):3664-7.
2004: Dyah Ayu Widiasih; Ibuki Matsuda; Katsuhiko Omoe; Dong-Liang Hu; Shunji Sugii; Kunihiro Shinagawa
Passive transfer of antibodies to Shiga toxin-producing Escherichia coli O26, O111 and O157 antigens in neonatal calves by feeding colostrum.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2004;66(2):213-5.
2004: Dyah Ayu Widiasih; N Ido; Katsuhiko Omoe; Shunji Sugii; Kunihiro Shinagawa
Duration and magnitude of faecal shedding of Shiga toxin-producing Escherichia coli from naturally infected cattle.
Epidemiology and infection 2004;132(1):67-75.
2003: Katsuhiko Omoe; Dong-Liang Hu; Hiromi Takahashi-Omoe; Akio Nakane; Kunihiro Shinagawa
Identification and characterization of a new staphylococcal enterotoxin-related putative toxin encoded by two kinds of plasmids.
Infection and immunity 2003;71(10):6088-94.
2003: Dong-Liang Hu; Katsuhiko Omoe; Sanae Sasaki; Hiroshi Sashinami; Hirotake Sakuraba; Yuichi Yokomizo; Kunihiro Shinagawa; Akio Nakane
Vaccination with nontoxic mutant toxic shock syndrome toxin 1 protects against Staphylococcus aureus infection.
The Journal of infectious diseases 2003;188(5):743-52.
2003: Dong-Liang Hu; Katsuhiko Omoe; Yu Shimoda; Akio Nakane; Kunihiro Shinagawa
Induction of emetic response to staphylococcal enterotoxins in the house musk shrew (Suncus murinus).
Infection and immunity 2003;71(1):567-70.
2002: Sanae Sasaki; Katsuhiko Omoe; Yoh ichi Tagawa; Yoichiro Iwakura; Kenji Sekikawa; Kunihiro Shinagawa; Akio Nakane
Roles of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality.
Microbial pathogenesis 2002;33(1):43-7.
2002: Katsuhiko Omoe; Machiko Ishikawa; Yu Shimoda; Dong-Liang Hu; Shigeko Ueda; Kunihiro Shinagawa
Detection of seg, seh, and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin productivities of S. aureus isolates Harboring seg, seh, or sei genes.
Journal of clinical microbiology 2002;40(3):857-62.
2001: Dong-Liang Hu; Katsuhiko Omoe; M H Saleh; K Ono; Shunji Sugii; Akio Nakane; Kunihiro Shinagawa
Analysis of the epitopes on staphylococcal enterotoxin A responsible for emetic activity.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2001;63(3):237-41.
2000: Kunihiro Shinagawa; M Kanehira; Katsuhiko Omoe; I Matsuda; D Hu; Dyah Ayu Widiasih; Shunji Sugii
Frequency of Shiga toxin-producing Escherichia coli in cattle at a breeding farm and at a slaughterhouse in Japan.
Veterinary microbiology 2000;76(3):305-9.
1999: Dong-Liang Hu; Katsuhiko Omoe; H Shimura; K Ono; Shunji Sugii; Kunihiro Shinagawa
Emesis in the shrew mouse (Suncus murinus) induced by peroral and intraperitoneal administration of staphylococcal enterotoxin A.
Journal of food protection 1999;62(11):1350-3.
1999: Dong-Liang Hu; Katsuhiko Omoe; Akio Nakane; Shunji Sugii; K Ono; S Sasaki; Kunihiro Shinagawa
Studies on the functional site on staphylococcal enterotoxin A responsible for production of murine gamma interferon.
FEMS immunology and medical microbiology 1999;25(3):237-44.
1998: Dong-Liang Hu; A Imai; K Ono; S Sasaki; Akio Nakane; Shunji Sugii; Kunihiro Shinagawa
Epitope analysis of staphylococcal enterotoxin A using different synthetic peptides.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1998;60(9):993-6.