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Jeffrey Bluestone

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TOP 3
Lukas T Jeker; Jeffrey A Bluestone
MicroRNA regulation of T-cell differentiation and function.
Jasmin Lebastchi; Steven Willi; Amir H Lebastchi; Eitan M Akirav; Isabel Beshar; Jeffrey A Bluestone; Songyan Deng; Stephen Gitelman; Peter Gottlieb; Kevan C Herold
Immune Therapy and β-Cell Death in Type 1 Diabetes.
Michael A Fischbach; Jeffrey A Bluestone; Wendell A Lim
Cell-based therapeutics: the next pillar of medicine.

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All Publications

2013: Lukas T Jeker; Jeffrey A Bluestone
MicroRNA regulation of T-cell differentiation and function.
Immunological reviews 2013;253(1):65-81.
2013: Jasmin Lebastchi; Steven Willi; Amir H Lebastchi; Eitan M Akirav; Isabel Beshar; Jeffrey A Bluestone; Songyan Deng; Stephen Gitelman; Peter Gottlieb; Kevan C Herold
Immune Therapy and β-Cell Death in Type 1 Diabetes.
Diabetes 2013;62(5):1676-80.
2013: Michael A Fischbach; Jeffrey A Bluestone; Wendell A Lim
Cell-based therapeutics: the next pillar of medicine.
Science translational medicine 2013;5(179):179ps7.
2013: Kevan C Herold; Dario A A Vignali; Anne Cooke; Jeffrey A Bluestone
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes.
Nature reviews. Immunology 2013;13(4):243-56.
2013: Abul K Abbas; Christophe Benoist; Jeffrey A Bluestone; Daniel J Campbell; Sankar Ghosh; Shohei Hori; Shuiping Jiang; Vijay K Kuchroo; Diane Mathis; Maria Grazia Roncarolo; Alexander Rudensky; Shimon Sakaguchi; Ethan M Shevach; Dario A A Vignali; Steve F Ziegler
Regulatory T cells: recommendations to simplify the nomenclature.
Nature immunology 2013;14(4):307-8.
2013: Melanie Stumpf; Xuyu Zhou; Jeffrey A Bluestone
The B7-independent isoform of CTLA-4 functions to regulate autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):961-9.
2012: Qizhi Tang; Jeffrey A Bluestone; Emmeline L Chuu; Sang-Mo Kang; Kimberly Lay; Joey Leung; Weihong Liu; Kristin Melli; V Ram Peddi; Flavio Vincenti
Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients.
Transplant international : official journal of the European Society for Organ Transplantation 2012;25(12):1257-67.
2012: Jeffrey A Bluestone; Hélène Bour-Jordan
Current and future immunomodulation strategies to restore tolerance in autoimmune diseases.
Cold Spring Harbor perspectives in biology 2012;4(11):.
2012: Mahesh Yadav; Bryan A Anthony; Samantha Bailey-Bucktrout; Dan Davini; James M Gardner; Richard Head; Daniel J Kuster; Cedric Louvet; Marc Martinez-Llordella; Peter Ruminski; Francis M Sverdrup; David von Schack; David Weiss; Jeffrey A Bluestone
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo.
The Journal of experimental medicine 2012;209(10):1713-22, S1-19.
2012: Cristina Penaranda; Lucy S K Walker; Abul K Abbas; Jeffrey A Bluestone; Jerry Hofmann; Rupert Kenefeck; Wilson Kuswanto; Parth Narendran; Hans Dooms
IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12668-73.
2012: Jeffrey A Bluestone; Eric J Small
The future of cancer treatment: will it include immunotherapy?
Cancer cell 2012;22(1):7-8.
2012: Chong Yon Park; Hunter Richards; Deepak Srivastava; Art Weiss; Yuko Yoshinaga; Michael Nefadov; Alyssia Oh; Abul K Abbas; David Adler; Jeffrey A Bluestone; Rachel Cameron; Karen Carver-Moore; Pieter J de Jong; Lukas T Jeker; Lewis L Lanier; Zhongmei Li; Huey Jiin Liu; Maria Martinez; Michael McManus
A resource for the conditional ablation of microRNAs in the mouse.
Cell reports 2012;1(4):385-91.
2012: Lukas T Jeker; Hélène Bour-Jordan; Jeffrey A Bluestone
Breakdown in peripheral tolerance in type 1 diabetes in mice and humans.
Cold Spring Harbor perspectives in medicine 2012;2(3):a007807.
2012: Qizhi Tang; Jeffrey A Bluestone; Sang-Mo Kang
CD4(+)Foxp3(+) regulatory T cell therapy in transplantation.
Journal of molecular cell biology 2012;4(1):11-21.
2012: Lukas T Jeker; Anders H Lund; Malika M Morar; Gustavo Stadthagen; Xuyu Zhou; Dimitri de Kouchkovsky; Kseniya Gershberg; Jeffrey A Bluestone
MicroRNA 10a marks regulatory T cells.
PloS one 2012;7(5):e36684.
2012: Joshua N Beilke; Jeffrey A Bluestone; Marine Champsaur; Karoline Hosiawa; Craig T Meagher; Lewis L Lanier
NK cells are not required for spontaneous autoimmune diabetes in NOD mice.
PloS one 2012;7(4):e36011.
2011: Cristina Penaranda; Qizhi Tang; Jeffrey A Bluestone
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(4):2015-22.
2011: Kevan C Herold; Jeffrey A Bluestone
Type 1 diabetes immunotherapy: is the glass half empty or half full?
Science translational medicine 2011;3(95):95fs1.
2011: Enric Esplugues; Jeffrey A Bluestone; Nicola Gagliani; Ann M Haberman; Anja E Hauser; Kevan C Herold; Samuel Huber; Yoichiro Iwakura; Jay K Kolls; Vijay K Kuchroo; William O'Connor; Anthony Rongvaux; Terrence Town; Nico van Rooijen; Yisong Y Wan; Richard A Flavell
Control of TH17 cells occurs in the small intestine.
Nature 2011;475(7357):514-8.
2011: Samantha L Bailey-Bucktrout; Jeffrey A Bluestone
Regulatory T cells: stability revisited.
Trends in immunology 2011;32(7):301-6.
2011: Dan Rainbow; William M Ridgway; Charles A Steward; John A Todd; Jeffrey A Bluestone; Oliver Burren; Mikkel Christensen; Jan Clark; Erik B Finger; Heather I Fraser; Michael E Fusakio; J P Houchins; Sarah Howlett; Frank Koentgen; Emma L Masteller; Jochen Mattner; Javid P Mohammed; Val Moody; Carolyn Moule; Dieter Naf; Laurence B Peterson; Linda S Wicker
Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(1):325-36.
2011: Helene Bour-Jordan; Jonathan H Esensten; Marc Martinez-Llordella; Cristina Penaranda; Melanie Stumpf; Jeffrey A Bluestone
Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family.
Immunological reviews 2011;241(1):180-205.
2011: Jeffrey A Bluestone
Mechanisms of tolerance.
Immunological reviews 2011;241(1):5-19.
2011: Stephanie A McClymont; Amy L Putnam; Michael R Lee; Jonathan Esensten; Weihong Liu; Maigan A Hulme; Ulrich Hoffmüller; Udo Baron; Sven Olek; Jeffrey A Bluestone; Todd Brusko
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):3918-26.
2011: Enayat Nikoopour; Christian Sandrock; Katrina Huszarik; Olga Krougly; Edwin Lee-Chan; Emma L Masteller; Jeffrey A Bluestone; Bhagirath Singh
Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(7):3831-5.
2010: Andrew M Posselt; Gregory L Szot; Lynda Frassetto; Umesh Masharani; Mehdi Tavakol; Raj Amin; Joan McElroy; Marissa D Ramos; Robert K Kerlan; Lawrence Fong; Flavio Vincenti; Jeffrey A Bluestone; Peter G Stock
Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade.
Transplantation 2010;90(12):1595-601.
2010: Jeffrey A Bluestone; Hugh Auchincloss; Gerald Nepom; Daniel Rotrosen; E William St Clair; Laurence A Turka
The Immune Tolerance Network at 10 years: tolerance research at the bedside.
Nature reviews. Immunology 2010;10(11):797-803.
2010: Andrew M Posselt; M D Bellin; M Tavakol; Gregory L Szot; Lynda Frassetto; Umesh Masharani; Robert K Kerlan; Lawrence Fong; Flavio Vincenti; B J Hering; Jeffrey A Bluestone; Peter G Stock
Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(8):1870-80.
2010: Laurence A Turka; Kathryn Wood; Jeffrey A Bluestone
Bringing transplantation tolerance into the clinic: lessons from the ITN and RISET for the Establishment of Tolerance consortia.
Current opinion in organ transplantation 2010;15(4):441-8.
2010: Lukas T Jeker; Jeffrey A Bluestone
Small RNA regulators of T cell-mediated autoimmunity.
Journal of clinical immunology 2010;30(3):347-57.
2010: Jeffrey A Bluestone; Kevan Herold; George Eisenbarth
Genetics, pathogenesis and clinical interventions in type 1 diabetes.
Nature 2010;464(7293):1293-300.
2010: Jeffrey A Bluestone; Alan M Krensky; Laurence A Turka; Daniel Rotrosen; Jeffrey B Matthews
Ten years of the Immune Tolerance Network: an integrated clinical research organization.
Science translational medicine 2010;2(19):19cm7.
2010: Todd Brusko; Richard C Koya; Shirley Zhu; Michael R Lee; Amy L Putnam; Stephanie A McClymont; Michael I Nishimura; Shuhong Han; Lung-Ji Chang; Mark A Atkinson; Antoni Ribas; Jeffrey A Bluestone
Human antigen-specific regulatory T cells generated by T cell receptor gene transfer.
PloS one 2010;5(7):e11726.
2009: Todd M Brusko; Jeffrey A Bluestone
Regulatory T cells directed to the site of the action.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20553-4.
2009: Jeffrey A Bluestone; Vijay Kuchroo
Autoimmunity.
Current opinion in immunology 2009;21(6):579-81.
2009: Jeffrey A Bluestone; Charles R Mackay; John J O'Shea; Brigitta Stockinger
The functional plasticity of T cell subsets.
Nature reviews. Immunology 2009;9(11):811-6.
2009: Cristina Penaranda; Jeffrey A Bluestone
Is antigen specificity of autoreactive T cells the key to islet entry?
Immunity 2009;31(4):534-6.
2009: Jonathan Esensten; David Wofsy; Jeffrey A Bluestone
Regulatory T cells as therapeutic targets in rheumatoid arthritis.
Nature reviews. Rheumatology 2009;5(10):560-5.
2009: Xuyu Zhou; Samantha L Bailey-Bucktrout; Lukas T Jeker; Cristina Penaranda; Marc Martínez-Llordella; Meredith Ashby; Maki Nakayama; Wendy Rosenthal; Jeffrey A Bluestone
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.
Nature immunology 2009;10(9):1000-7.
2009: Kevan C Herold; Stephen Gitelman; Carla Greenbaum; Jennifer Puck; William Hagopian; Peter Gottlieb; Peter Sayre; Peter Bianchine; Emelita Wong; Vicki Seyfert-Margolis; Kasia Bourcier; Jeffrey A Bluestone
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.
Clinical immunology (Orlando, Fla.) 2009;132(2):166-73.
2009: Sylvain Perruche; Pin Zhang; Takashi Maruyama; Jeffrey A Bluestone; Philippe Saas; Wanjun Chen
Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):953-61.
2009: Jonathan Esensten; Michael R Lee; Laurie H Glimcher; Jeffrey A Bluestone
T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):75-82.
2009: Xuyu Zhou; Samantha Bailey-Bucktrout; Lukas T Jeker; Jeffrey A Bluestone
Plasticity of CD4(+) FoxP3(+) T cells.
Current opinion in immunology 2009;21(3):281-5.
2009: Hélène Bour-Jordan; Jeffrey A Bluestone
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Immunological reviews 2009;229(1):41-66.
2009: Maureen A Su; Matthew Stenerson; Weihong Liu; Amy Putnam; Felix Conte; Jeffrey A Bluestone; Mark S Anderson
The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.
Clinical immunology (Orlando, Fla.) 2009;131(1):139-44.
2009: Cédric Louvet; Beniwende G Kabre; Dan W Davini; Nicolas Martinier; Maureen A Su; Jason DeVoss; Wendy L Rosenthal; Mark S Anderson; Helene Bour-Jordan; Jeffrey A Bluestone
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.
The Journal of experimental medicine 2009;206(3):507-14.
2008: Cédric Louvet; Gregory L Szot; Jiena Lang; Michael R Lee; Nicolas Martinier; Gideon Bollag; Shirley Zhu; Arthur Weiss; Jeffrey A Bluestone
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18895-900.
2008: Jeffrey A Bluestone; Qizhi Tang; Caitlin E Sedwick
T regulatory cells in autoimmune diabetes: past challenges, future prospects.
Journal of clinical immunology 2008;28(6):677-84.
2008: Li Wen; Ruth E Ley; Pavel Yu Volchkov; Peter B Stranges; Lia Avanesyan; Austin C Stonebraker; Changyun Hu; F Susan Wong; Gregory L Szot; Jeffrey A Bluestone; Jeffrey I Gordon; Alexander V Chervonsky
Innate immunity and intestinal microbiota in the development of Type 1 diabetes.
Nature 2008;455(7216):1109-13.
2008: Jeffrey A Bluestone; Weihong Liu; J M Yabu; Z G Laszik; Amy L Putnam; M Belingheri; D M Gross; R M Townsend; Flavio Vincenti
The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(10):2086-96.
2008: Xuyu Zhou; Lukas T Jeker; Brian T Fife; Shirley Zhu; Mark S Anderson; Michael McManus; Jeffrey A Bluestone
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.
The Journal of experimental medicine 2008;205(9):1983-91.
2008: Brian T Fife; Jeffrey A Bluestone
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.
Immunological reviews 2008;224():166-82.
2008: Craig Meagher; Qizhi Tang; Brian T Fife; Helene Bour-Jordan; Jenny Wu; Cecile Pardoux; Mingying Bi; Kristin Melli; Jeffrey A Bluestone
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7793-803.
2008: Todd Brusko; Amy L Putnam; Jeffrey A Bluestone
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.
Immunological reviews 2008;223():371-90.
2008: Qizhi Tang; Jason Y Adams; Cristina Penaranda; Kristin Melli; Eliane Piaggio; Evridiki Sgouroudis; Ciriaco Piccirillo; Benoît L Salomon; Jeffrey A Bluestone
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.
Immunity 2008;28(5):687-97.
2008: Sylvain Perruche; Pin Zhang; Yongzhong Liu; Philippe Saas; Jeffrey A Bluestone; Wanjun Chen
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
Nature medicine 2008;14(5):528-35.
2008: David A Cano; Ingrid C Rulifson; Patrick W Heiser; Lamorna Brown Swigart; Stella Pelengaris; Michael S German; Gerard I Evan; Jeffrey A Bluestone; Matthias Hebrok
Regulated beta-cell regeneration in the adult mouse pancreas.
Diabetes 2008;57(4):958-66.
2008: Qizhi Tang; Jeffrey A Bluestone
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation.
Nature immunology 2008;9(3):239-44.
2007: Helene Bour-Jordan; Jeffrey A Bluestone
B cell depletion: a novel therapy for autoimmune diabetes?
The Journal of clinical investigation 2007;117(12):3642-5.
2007: Nicole A Sherry; Wei Chen; Jake A Kushner; Mariela Glandt; Qizhi Tang; Sue Tsai; Pere Santamaria; Jeffrey A Bluestone; Anne-Marie B Brillantes; Kevan C Herold
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.
Endocrinology 2007;148(11):5136-44.
2007: Indira Guleria; Melanie Gubbels Bupp; Shirine Dada; Brian T Fife; Qizhi Tang; Mohammed Javeed I Ansari; Subbulaxmi Trikudanathan; Nidyanandh Vadivel; Paolo Fiorina; Hideo Yagita; Miyuki Azuma; Mark Atkinson; Jeffrey A Bluestone; Mohamed H Sayegh
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Clinical immunology (Orlando, Fla.) 2007;125(1):16-25.
2007: Mark A Travis; Boris Reizis; Andrew C Melton; Emma L Masteller; Qizhi Tang; John M Proctor; Yanli Wang; Xin Bernstein; Xiaozhu Huang; Louis F Reichardt; Jeffrey A Bluestone; Dean Sheppard
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.
Nature 2007;449(7160):361-5.
2007: Helene Bour-Jordan; Benoît L Salomon; Heather L Thompson; Rex Santos; Abul K Abbas; Jeffrey A Bluestone
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1004-12.
2007: Sang-Mo Kang; Qizhi Tang; Jeffrey A Bluestone
CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(6):1457-63.
2007: Shunsuke Chikuma; Jeffrey A Bluestone
Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
European journal of immunology 2007;37(5):1285-9.
2007: Gregory L Szot; Pavel Koudria; Jeffrey A Bluestone
Transplantation of pancreatic islets into the kidney capsule of diabetic mice.
Journal of visualized experiments : JoVE 2007;(9):404.
2007: Gregory L Szot; Pavel Koudria; Jeffrey A Bluestone
Murine pancreatic islet isolation.
Journal of visualized experiments : JoVE 2007;(7):255.
2006: Helene Bour-Jordan; Jeffrey A Bluestone
Sensory neurons link the nervous system and autoimmune diabetes.
Cell 2006;127(6):1097-9.
2006: Brian T Fife; Indira Guleria; Melanie Gubbels Bupp; Todd N Eagar; Qizhi Tang; Helene Bour-Jordan; Hideo Yagita; Miyuki Azuma; Mohamed H Sayegh; Jeffrey A Bluestone
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
The Journal of experimental medicine 2006;203(12):2737-47.
2006: Vicki Seyfert-Margolis; Trang D Gisler; Adam L Asare; Richard S Wang; H Michael Dosch; Barbara Brooks-Worrell; George S Eisenbarth; Jerry P Palmer; Carla J Greenbaum; Stephen E Gitelman; Gerald Nepom; Jeffrey A Bluestone; Kevan C Herold
Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.
Diabetes 2006;55(9):2588-94.
2006: Qizhi Tang; Jeffrey A Bluestone
Regulatory T-cell physiology and application to treat autoimmunity.
Immunological reviews 2006;212():217-37.
2006: Brian T Fife; Matthew D Griffin; Abul K Abbas; Richard M Locksley; Jeffrey A Bluestone
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
The Journal of clinical investigation 2006;116(8):2252-61.
2006: Kenneth J Scalapino; Qizhi Tang; Jeffrey A Bluestone; Mark Bonyhadi; David I Daikh
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1451-9.
2006: Weihong Liu; Amy L Putnam; Zhou Xu-Yu; Gregory L Szot; Michael R Lee; Shirley Zhu; Peter A Gottlieb; Philipp Kapranov; Thomas Gingeras; Barbara Fazekas De St Groth; Carol Clayberger; David M Soper; Steven F Ziegler; Jeffrey A Bluestone
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.
The Journal of experimental medicine 2006;203(7):1701-11.
2006: Emma L Masteller; Qizhi Tang; Jeffrey A Bluestone
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.
Seminars in immunology 2006;18(2):103-10.
2006: Jeffrey A Bluestone; E William St Clair; Laurence A Turka
CTLA4Ig: bridging the basic immunology with clinical application.
Immunity 2006;24(3):233-8.
2006: Qizhi Tang; Jason Y Adams; Aaron J Tooley; Mingying Bi; Brian T Fife; Pau Serra; Pere Santamaria; Richard M Locksley; Matthew F Krummel; Jeffrey A Bluestone
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Nature immunology 2006;7(1):83-92.
2005: Jeffrey A Bluestone; Qizhi Tang
How do CD4+CD25+ regulatory T cells control autoimmunity?
Current opinion in immunology 2005;17(6):638-42.
2005: Birgit Knoechel; Jens Lohr; Estelle Kahn; Jeffrey A Bluestone; Abul K Abbas
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
The Journal of experimental medicine 2005;202(10):1375-86.
2005: Helene Bour-Jordan; Heather L Thompson; Jeffrey A Bluestone
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5649-55.
2005: Brygida Bisikirska; John Colgan; Jeremy Luban; Jeffrey A Bluestone; Kevan C Herold
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.
The Journal of clinical investigation 2005;115(10):2904-13.
2005: Yang D Dai; Kent P Jensen; Agnès Lehuen; Emma L Masteller; Jeffrey A Bluestone; Darcy B Wilson; Eli E Sercarz
A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3621-7.
2005: Wei Chen; Jeffrey A Bluestone; Kevan C Herold
Achieving antigen-specific tolerance in diabetes: regulating specifically.
International reviews of immunology 2005;24(5-6):287-305.
2005: Emma L Masteller; Matthew R Warner; Qizhi Tang; Kristin V Tarbell; Hugh McDevitt; Jeffrey A Bluestone
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3053-9.
2005: Shunsuke Chikuma; Abul K Abbas; Jeffrey A Bluestone
B7-independent inhibition of T cells by CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):177-81.
2005: Kevan C Herold; Stephen E Gitelman; Umesh Masharani; William Hagopian; Brygida Bisikirska; David Donaldson; Kristina I Rother; Beverly Diamond; David M Harlan; Jeffrey A Bluestone
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
Diabetes 2005;54(6):1763-9.
2005: Jelena S Bezbradica; Aleksandar Stanic; Naoto Matsuki; Helene Bour-Jordan; Jeffrey A Bluestone; James W Thomas; Derya Unutmaz; Luc Van Kaer; Sebastian JOYCE
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4696-705.
2005: Adam P Kohm; Julie S Williams; Allison L Bickford; Jeffrey S McMahon; Lucienne Chatenoud; Jean-François Bach; Jeffrey A Bluestone; Stephen D Miller
Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4525-34.
2005: Jeffrey A Bluestone
Regulatory T-cell therapy: is it ready for the clinic?
Nature reviews. Immunology 2005;5(4):343-9.
2005: Mark S Anderson; Jeffrey A Bluestone
The NOD mouse: a model of immune dysregulation.
Annual review of immunology 2005;23():447-85.
2004: Qizhi Tang; Elisa K Boden; Kammi J Henriksen; Helene Bour-Jordan; Mingying Bi; Jeffrey A Bluestone
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
European journal of immunology 2004;34(11):2996-3005.
2004: Jeffrey A Bluestone; Qizhi Tang
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101 Suppl 2():14622-6.
2004: Helene Bour-Jordan; Benoît L Salomon; Heather L Thompson; Gregory L Szot; Matthew R Bernhard; Jeffrey A Bluestone
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.
The Journal of clinical investigation 2004;114(7):979-87.
2004: Valeria Judkowski; Enrique Rodriguez; Clemencia Pinilla; Emma L Masteller; Jeffrey A Bluestone; Nora Sarvetnick; Darcy B Wilson
Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes.
Clinical immunology (Orlando, Fla.) 2004;113(1):29-37.
2004: Todd N Eagar; Danielle M Turley; Josette Padilla; Nitin J Karandikar; Litjen (L.J) Tan; Jeffrey A Bluestone; Stephen D Miller
CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7442-50.
2004: Qizhi Tang; Kammi J Henriksen; Mingying Bi; Erik B Finger; Gregory L Szot; Jianqin Ye; Emma L Masteller; Hugh McDevitt; Mark Bonyhadi; Jeffrey A Bluestone
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
The Journal of experimental medicine 2004;199(11):1455-65.
2004: Kouetsu Ogasawara; Jessica A Hamerman; Lauren R Ehrlich; Helene Bour-Jordan; Pere Santamaria; Jeffrey A Bluestone; Lewis L Lanier
NKG2D blockade prevents autoimmune diabetes in NOD mice.
Immunity 2004;20(6):757-67.
2004: Todd N Eagar; Qizhi Tang; Michael S Wolfe; Yiping He; Warren S Pear; Jeffrey A Bluestone
Notch 1 signaling regulates peripheral T cell activation.
Immunity 2004;20(4):407-15.
2004: Chynna Steele; William Hagopian; Stephen E Gitelman; Umesh Masharani; Melissa Cavaghan; Kristina I Rother; David Donaldson; David M Harlan; Jeffrey A Bluestone; Kevan C Herold
Insulin secretion in type 1 diabetes.
Diabetes 2004;53(2):426-33.
2004: Vladimir M Jovasevic; Leonid Gorelik; Jeffrey A Bluestone; Margalit B Mokyr
Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1449-54.
2004: Peter G Stock; Jeffrey A Bluestone
Beta-cell replacement for type I diabetes.
Annual review of medicine 2004;55():133-56.
2003: Emma L Masteller; Matthew R Warner; Walter Ferlin; Valeria Judkowski; Darcy Wilson; Nicolas Glaichenhaus; Jeffrey A Bluestone
Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5587-95.
2003: Qizhi Tang; Kammi J Henriksen; Elisa K Boden; Aaron J Tooley; Jianqin Ye; Sumit K Subudhi; Xin Xiao Zheng; Terry B Strom; Jeffrey A Bluestone
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3348-52.
2003: Jeffrey B Matthews; Eleanor Ramos; Jeffrey A Bluestone
Clinical trials of transplant tolerance: slow but steady progress.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):794-803.
2003: Jeffrey A Bluestone; Abul K Abbas
Natural versus adaptive regulatory T cells.
Nature reviews. Immunology 2003;3(3):253-7.
2003: Scott E Starwalt; Emma L Masteller; Jeffrey A Bluestone; David M Kranz
Directed evolution of a single-chain class II MHC product by yeast display.
Protein engineering 2003;16(2):147-56.
2003: Kevan C Herold; Joshua B Burton; Fleur Francois; Ena Poumian-Ruiz; Mariela Glandt; Jeffrey A Bluestone
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).
The Journal of clinical investigation 2003;111(3):409-18.
2003: Qizhi Tang; Judy A Smith; Gregory L Szot; Ping Zhou; Maria-Luisa Alegre; Kammi J Henriksen; Craig Thompson; Jeffrey A Bluestone
CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1510-6.
2003: Helene Bour-Jordan; Jane Grogan; Qizhi Tang; Julie A Auger; Richard M Locksley; Jeffrey A Bluestone
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Nature immunology 2003;4(2):182-8.
2003: Elisa K Boden; Qizhi Tang; Helene Bour-Jordan; Jeffrey A Bluestone
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
Novartis Foundation symposium 2003;252():55-63; discussion 63-6, 106-14.
2003: Kouetsu Ogasawara; Jessica A Hamerman; Honor Hsin; Shunsuke Chikuma; Helene Bour-Jordan; Taian Chen; Thomas Pertel; Claude Carnaud; Jeffrey A Bluestone; Lewis L Lanier
Impairment of NK cell function by NKG2D modulation in NOD mice.
Immunity 2003;18(1):41-51.
2002: Emma L Masteller; Jeffrey A Bluestone
Immunotherapy of insulin-dependent diabetes mellitus.
Current opinion in immunology 2002;14(5):652-9.
2002: Tammy O Utset; Julie A Auger; Donna Peace; Robert A Zivin; Danlin Xu; Linda Jolliffe; Maria-Luisa Alegre; Jeffrey A Bluestone; Marcus R Clark
Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.
The Journal of rheumatology 2002;29(9):1907-13.
2002: Kwang Woo Hwang; William B Sweatt; Ian E Brown; Christian Blank; Thomas F Gajewski; Jeffrey A Bluestone; Maria-Luisa Alegre
Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):633-7.
2002: Shunsuke Chikuma; Jeffrey A Bluestone
CTLA-4: acting at the synapse.
Molecular interventions 2002;2(4):205-8.
2002: Ingrid C Rulifson; Gregory L Szot; Ed Palmer; Jeffrey A Bluestone
Inability to induce tolerance through direct antigen presentation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(6):510-9.
2002: Kevan C Herold; William Hagopian; Julie A Auger; Ena Poumian-Ruiz; Lesley Taylor; David Donaldson; Stephen E Gitelman; David M Harlan; Danlin Xu; Robert A Zivin; Jeffrey A Bluestone
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.
The New England journal of medicine 2002;346(22):1692-8.
2002: Qizhi Tang; Sumit K Subudhi; Kammi J Henriksen; Catherine G Long; Franklin Vives; Jeffrey A Bluestone
The Src family kinase Fyn mediates signals induced by TCR antagonists.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4480-7.
2002: Todd N Eagar; Nitin J Karandikar; Jeffrey A Bluestone; Stephen D Miller
The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.
European journal of immunology 2002;32(4):972-81.
2001: Benoît L Salomon; L Rhee; Helene Bour-Jordan; H Hsin; A Montag; Betty Soliven; J Arcella; Ann M Girvin; J Padilla; Stephen D Miller; Jeffrey A Bluestone
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.
The Journal of experimental medicine 2001;194(5):677-84.
2001: SM O'Herrin; Jill E Slansky; Q Tang; Mary A. Markiewicz; Thomas F Gajewski; Drew M Pardoll; Jonathan P Schneck; Jeffrey A Bluestone
Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2555-60.
2001: A G Tesciuba; Sumit K Subudhi; Russell P Rother; Susan J Faas; A M Frantz; D Elliot; Joel Weinstock; LA Matis; Jeffrey A Bluestone; Anne I Sperling
Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1996-2003.
2001: Anne I Sperling; Jeffrey A Bluestone
ICOS costimulation: It's not just for TH2 cells anymore.
Nature immunology 2001;2(7):573-4.
2001: Qiang Wu; Benoît L Salomon; M Chen; Youli Wang; L M Hoffman; Jeffrey A Bluestone; Yang-Xin Fu
Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor.
The Journal of experimental medicine 2001;193(11):1327-32.
2001: Manjula Donepudi; Pradip Raychaudhuri; Jeffrey A Bluestone; Margalit B Mokyr
Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6491-9.
2001: Gregory L Szot; Ping Zhou; Ingrid C Rulifson; Jun Wang; Zhong Guo; Oliver Kim; K A Newel; J Richard Thistlethwaite; Jeffrey A Bluestone; Maria-Luisa Alegre
Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2001;1(1):38-46.
2001: Ping Zhou; Gregory L Szot; Zhong Guo; Oliver Kim; Gang He; Jun Wang; M Grusby; K Newell; J Richard Thistlethwaite; Jeffrey A Bluestone; M Alegre
Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Transplantation proceedings 2001;33(1-2):214-6.
2001: M Alegre; Francesca Fallarino; Ping Zhou; Kenneth A Frauwirth; J Richard Thistlethwaite; K Newell; Thomas F Gajewski; Jeffrey A Bluestone
Transplantation and the CD28/CTLA4/B7 pathway.
Transplantation proceedings 2001;33(1-2):209-11.
2001: MD Griffin; P O Holman; Q Tang; N Ashourian; U Korthäuer; David M Kranz; Jeffrey A Bluestone
Development and applications of surface-linked single chain antibodies against T-cell antigens.
Journal of immunological methods 2001;248(1-2):77-90.
2001: Benoît L Salomon; Jeffrey A Bluestone
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.
Annual review of immunology 2001;19():225-52.
2000: Ping Zhou; Gregory L Szot; Zhong Guo; Oliver Kim; Gang He; Jun Wang; M J Grusby; Kenneth A Newell; J Richard Thistlethwaite; Jeffrey A Bluestone; Maria-Luisa Alegre
Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5580-7.
2000: Jeffrey A Bluestone; J B Matthews; Alan Krensky
The immune tolerance network: the "Holy Grail" comes to the clinic.
Journal of the American Society of Nephrology : JASN 2000;11(11):2141-6.
2000: Nitin J Karandikar; Todd N Eagar; Carol L Vanderlugt; Jeffrey A Bluestone; Stephen D Miller
CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2000;109(2):173-80.
2000: Katherine L Neville; Mauro C Dal Canto; Jeffrey A Bluestone; Stephen D Miller
CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.
Journal of virology 2000;74(18):8349-57.
2000: Dorothy K Sojka; Manjula Donepudi; Jeffrey A Bluestone; Margalit B Mokyr
Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6230-6.
2000: MD Griffin; D K Hong; P O Holman; Kyung-Mi Lee; M J Whitters; SM O'Herrin; Francesca Fallarino; M Collins; D M Segal; Thomas F Gajewski; David M Kranz; Jeffrey A Bluestone
Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4433-42.
2000: Benoît L Salomon; D J Lenschow; L Rhee; N Ashourian; Bhagirath Singh; A Sharpe; Jeffrey A Bluestone
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Immunity 2000;12(4):431-40.
2000: Gregory L Szot; Ping Zhou; Arlene H Sharpe; Gang He; Oliver Kim; Kenneth A Newell; Jeffrey A Bluestone; J Richard Thistlethwaite
Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.
Transplantation 2000;69(5):904-9.
2000: Danlin Xu; M L Alegre; SS Varga; A L Rothermel; A M Collins; Virginia L Pulito; L S Hanna; K P Dolan; P W Parren; Jeffrey A Bluestone; Linda Jolliffe; Robert A Zivin
In vitro characterization of five humanized OKT3 effector function variant antibodies.
Cellular immunology 2000;200(1):16-26.
2000: Carol L Vanderlugt; Katherine L Neville; K M Nikcevich; Todd N Eagar; Jeffrey A Bluestone; Stephen D Miller
Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):670-8.
2000: U Korthäuer; Wolfram Nagel; Elizabeth M Davis; Michelle M Le Beau; R S Menon; E O Mitchell; C A Kozak; Waldemar Kolanus; Jeffrey A Bluestone
Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):308-18.
2000: Ann M Girvin; Mauro C Dal Canto; L Rhee; Benoît L Salomon; A Sharpe; Jeffrey A Bluestone; Stephen D Miller
A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):136-43.
1999: K Rajagopal; Connie L Sommers; Donna C Decker; E O Mitchell; U Korthauer; Anne I Sperling; C A Kozak; Paul E Love; Jeffrey A Bluestone
RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
The Journal of experimental medicine 1999;190(11):1657-68.
1999: M Mathur; K Herrmann; Y Qin; F Gulmen; X Li; R Krimins; Joel Weinstock; David Elliott; Jeffrey A Bluestone; PA Padrid
CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice.
American journal of respiratory cell and molecular biology 1999;21(4):498-509.
1999: E Steve Woodle; Danlin Xu; Robert A Zivin; Julie A Auger; J Charette; R O'Laughlin; Donna Peace; L K Jollife; T Haverty; Jeffrey A Bluestone; J Richard Thistlethwaite
Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection.
Transplantation 1999;68(5):608-16.
1999: Kenneth A Newell; Gang He; Zhong Guo; Oliver Kim; Gregory L Szot; Ingrid C Rulifson; Ping Zhou; John Hart; J Richard Thistlethwaite; Jeffrey A Bluestone
Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2358-62.
1999: B R Theriault; J Richard Thistlethwaite; Matteo G Levisetti; Craig L Wardrip; Gregory L Szot; David S Bruce; H Rilo; X Li; GS Gray; Jeffrey A Bluestone; PA Padrid
Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis).
Transplantation 1999;68(3):331-7.
1999: R Khattri; J A Auger; MD Griffin; Arlene H Sharpe; Jeffrey A Bluestone
Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5784-91.
1999: J Richards; Julie A Auger; Donna Peace; D Gale; J Michel; A Koons; T Haverty; Robert A Zivin; Linda Jolliffe; Jeffrey A Bluestone
Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.
Cancer research 1999;59(9):2096-101.
1999: RN La Motte; A H Sharpe; Jeffrey A Bluestone; Margalit B Mokyr
Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4817-23.
1999: Roger Sciammas; Jeffrey A Bluestone
TCRgammadelta cells and viruses.
Microbes and infection / Institut Pasteur 1999;1(3):203-12.
1999: Ellen Chuang; Kyung-Mi Lee; M D Robbins; J M Duerr; Maria-Luisa Alegre; J E Hambor; Mark Neveu; Jeffrey A Bluestone; Craig Thompson
Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1270-7.
1999: K A Kaufman; JA Bowen; A F Tsai; Jeffrey A Bluestone; Joan S Hunt; Carole Ober
The CTLA-4 gene is expressed in placental fibroblasts.
Molecular human reproduction 1999;5(1):84-7.
1998: Kyung-Mi Lee; Ellen Chuang; M Griffin; R Khattri; D K Hong; W Zhang; D Straus; L E Samelson; Craig Thompson; Jeffrey A Bluestone
Molecular basis of T cell inactivation by CTLA-4.
Science (New York, N.Y.) 1998;282(5397):2263-6.
1998: RN La Motte; A H Sharpe; Jeffrey A Bluestone; Margalit B Mokyr
Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6552-8.
1998: Margalit B Mokyr; TV Kalinichenko; Leonid Gorelik; Jeffrey A Bluestone
Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice.
Cancer research 1998;58(23):5301-4.
1998: Roger Sciammas; Jeffrey A Bluestone
HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5187-92.
1998: Benoît L Salomon; Jeffrey A Bluestone
LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5138-42.
1998: Jeffrey A Bluestone
Cell fate in the immune system: decisions, decisions, decisions.
Immunological reviews 1998;165():5-12.
1998: Nitin J Karandikar; Carol L Vanderlugt; Jeffrey A Bluestone; Stephen D Miller
Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.
Journal of neuroimmunology 1998;89(1-2):10-8.
1998: Carol L Vanderlugt; Wendy Smith Begolka; Katherine L Neville; Y Katz-Levy; Laurence Howard; Todd N Eagar; Jeffrey A Bluestone; Stephen D Miller
The functional significance of epitope spreading and its regulation by co-stimulatory molecules.
Immunological reviews 1998;164():63-72.
1998: Nitin J Karandikar; Carol L Vanderlugt; Todd N Eagar; Litjen (L.J) Tan; Jeffrey A Bluestone; Stephen D Miller
Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):192-9.
1998: E Steve Woodle; Jeffrey A Bluestone; Robert A Zivin; Linda Jolliffe; Julie A Auger; Danlin Xu; J Richard Thistlethwaite
Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience.
Transplantation proceedings 1998;30(4):1369-70.
1998: J A Smith; Q Tang; Jeffrey A Bluestone
Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4841-9.
1998: TL Walunas; Jeffrey A Bluestone
CTLA-4 regulates tolerance induction and T cell differentiation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3855-60.
1998: PA Padrid; M Mathur; X Li; K Herrmann; Y Qin; A Cattamanchi; Joel Weinstock; David Elliott; Anne I Sperling; Jeffrey A Bluestone
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.
American journal of respiratory cell and molecular biology 1998;18(4):453-62.
1998: Margalit B Mokyr; TV Kalinichenko; Leonid Gorelik; Jeffrey A Bluestone
Importance of the B7-2 molecule for low dose melphalan-induced acquisition of tumor-eradicating immunity by mice bearing a large MOPC-315 tumor.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1866-74.
1997: Matteo G Levisetti; PA Padrid; Gregory L Szot; N Mittal; S M Meehan; Craig L Wardrip; GS Gray; David S Bruce; J Richard Thistlethwaite; Jeffrey A Bluestone
Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5187-91.
1997: Carol L Vanderlugt; Nitin J Karandikar; D J Lenschow; Mauro C Dal Canto; Jeffrey A Bluestone; Stephen D Miller
Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE.
Journal of neuroimmunology 1997;79(2):113-8.
1997: KC Herold; J Lu; I Rulifson; V Vezys; D Taub; M J Grusby; Jeffrey A Bluestone
Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4150-3.
1997: J A Smith; Jeffrey A Bluestone
T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs.
Current opinion in immunology 1997;9(5):648-54.
1997: M Wick; Purnima Dubey; H Koeppen; CT Siegel; PE Fields; Lieping Chen; Jeffrey A Bluestone; Hans Schreiber
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
The Journal of experimental medicine 1997;186(2):229-38.
1997: Anne I Sperling; Donna C Decker; Richard DiPaolo; D A Stern; A Shum; Jeffrey A Bluestone
Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):86-91.
1997: Roger Sciammas; P Kodukula; Q Tang; RL Hendricks; Jeffrey A Bluestone
T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.
The Journal of experimental medicine 1997;185(11):1969-75.
1997: J A Smith; JY Tso; M R Clark; MS Cole; Jeffrey A Bluestone
Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy.
The Journal of experimental medicine 1997;185(8):1413-22.
1997: E Steve Woodle; D M Smith; Jeffrey A Bluestone; W M Kirkman; D R Green; Skowronski Evan
Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2156-64.
1997: Jeffrey A Bluestone
Is CTLA-4 a master switch for peripheral T cell tolerance?
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):1989-93.
1997: E Steve Woodle; D M Smith; Jeffrey A Bluestone; D R Green; Skowronski Evan
Class I MHC mediates programmed cell death in a Fas-independent manner.
Transplantation proceedings 1997;29(1-2):1101.
1997: K G Herold; D J Lenschow; Jeffrey A Bluestone
CD28/B7 regulation of autoimmune diabetes.
Immunologic research 1997;16(1):71-84.
1997: KC Herold; V Vezys; A Koons; D Lenschow; Craig Thompson; Jeffrey A Bluestone
CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):984-91.
1997: Ingrid C Rulifson; Anne I Sperling; PE Fields; FW Fitch; Jeffrey A Bluestone
CD28 costimulation promotes the production of Th2 cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):658-65.
1996: Anne I Sperling; J A Auger; Benjamin D Ehst; I C Rulifson; Craig Thompson; Jeffrey A Bluestone
CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3909-17.
1996: Anne I Sperling; Jeffrey A Bluestone
The complexities of T-cell co-stimulation: CD28 and beyond.
Immunological reviews 1996;153():155-82.
1996: R Khattri; Anne I Sperling; D Qian; F W Fitch; Elizabeth W Shores; Paul E Love; Jeffrey A Bluestone
TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2320-7.
1996: D J Lenschow; KC Herold; L Rhee; B Patel; A Koons; H Y Qin; E Fuchs; Bhagirath Singh; Craig Thompson; Jeffrey A Bluestone
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.
Immunity 1996;5(3):285-93.
1996: Nitin J Karandikar; Carol L Vanderlugt; T L Walunas; Stephen D Miller; Jeffrey A Bluestone
CTLA-4: a negative regulator of autoimmune disease.
The Journal of experimental medicine 1996;184(2):783-8.
1996: T L Walunas; C Y Bakker; Jeffrey A Bluestone
CTLA-4 ligation blocks CD28-dependent T cell activation.
The Journal of experimental medicine 1996;183(6):2541-50.
1996: E Steve Woodle; S Hussein; Jeffrey A Bluestone
In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells.
Transplantation 1996;61(5):798-803.
1996: R N La Motte; M A Rubin; E Barr; J M Leiden; Jeffrey A Bluestone; Margalit B Mokyr
Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule.
Cancer immunology, immunotherapy : CII 1996;42(3):161-9.
1996: Jeffrey A Bluestone
Costimulation and its role in organ transplantation.
Clinical transplantation 1996;10(1 Pt 2):104-9.
1996: T L Walunas; Anne I Sperling; R Khattri; Craig Thompson; Jeffrey A Bluestone
CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1006-13.
1996: D J Lenschow; T L Walunas; Jeffrey A Bluestone
CD28/B7 system of T cell costimulation.
Annual review of immunology 1996;14():233-58.
1995: Stephen D Miller; Carol L Vanderlugt; D J Lenschow; J G Pope; Nitin J Karandikar; Mauro C Dal Canto; Jeffrey A Bluestone
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE.
Immunity 1995;3(6):739-45.
1995: D J Lenschow; Y Zeng; K S Hathcock; L A Zuckerman; G Freeman; J Richard Thistlethwaite; GS Gray; Richard J Hodes; Jeffrey A Bluestone
Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies.
Transplantation 1995;60(10):1171-8.
1995: A Kaliyaperumal; R Falchetto; Andrea L Cox; R Dick; Jeffrey Shabanowitz; Yueh-hsiu Chien; L Matis; Donald F Hunt; Jeffrey A Bluestone
Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2379-86.
1995: T L Walunas; David S Bruce; L Dustin; D Y Loh; Jeffrey A Bluestone
Ly-6C is a marker of memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1873-83.
1995: Maria-Luisa Alegre; J Y Tso; H A Sattar; J Smith; F Desalle; M Cole; Jeffrey A Bluestone
An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1544-55.
1995: E R Kearney; T L Walunas; R W Karr; P A Morton; D Y Loh; Jeffrey A Bluestone; Marc K Jenkins
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1032-6.
1995: Anne I Sperling; J M Green; R L Mosley; P L Smith; Richard DiPaolo; J R Klein; Jeffrey A Bluestone; Craig Thompson
CD43 is a murine T cell costimulatory receptor that functions independently of CD28.
The Journal of experimental medicine 1995;182(1):139-46.
1995: Jeffrey A Bluestone
New perspectives of CD28-B7-mediated T cell costimulation.
Immunity 1995;2(6):555-9.
1995: J M Green; P J Noel; Anne I Sperling; T L Walunas; D J Lenschow; R Stack; GS Gray; Jeffrey A Bluestone; Craig Thompson
T cell costimulation through the CD28 receptor.
Proceedings of the Association of American Physicians 1995;107(1):41-6.
1995: D J Lenschow; S C Ho; H Sattar; L Rhee; G Gray; N Nabavi; KC Herold; Jeffrey A Bluestone
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.
The Journal of experimental medicine 1995;181(3):1145-55.
1995: D M Smith; Jeffrey A Bluestone; J Richard Thistlethwaite; E Steve Woodle
Inhibition of T-cell activation by an anti-human class I MHC reactive monoclonal antibody occurs at a point distal to TCR-CD3 mediated signal transduction.
Transplantation proceedings 1995;27(1):395-7.
1995: Dominick DeLuca; Jeffrey A Bluestone; L D Shultz; S O Sharrow; Y Tatsumi
Programmed differentiation of murine thymocytes during fetal thymus organ culture.
Journal of immunological methods 1995;178(1):13-29.
1995: Jeffrey A Bluestone; R Khattri; Roger Sciammas; Anne I Sperling
TCR gamma delta cells: a specialized T-cell subset in the immune system.
Annual review of cell and developmental biology 1995;11():307-53.
1995: Maria-Luisa Alegre; D J Lenschow; Jeffrey A Bluestone
Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.
Digestive diseases and sciences 1995;40(1):58-64.
1994: Margalit B Mokyr; A Prokhorova; M Rubin; Jeffrey A Bluestone
Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3123-34.
1994: Y Zeng; A Gage; A Montag; R Rothlein; J Richard Thistlethwaite; Jeffrey A Bluestone
Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies.
Transplantation 1994;58(6):681-9.
1994: Maria-Luisa Alegre; L J Peterson; D R Jeyarajah; Martin R Weiser; Jeffrey A Bluestone; J Richard Thistlethwaite
Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2738-49.
1994: J M Green; P J Noel; Anne I Sperling; T L Walunas; GS Gray; Jeffrey A Bluestone; Craig Thompson
Absence of B7-dependent responses in CD28-deficient mice.
Immunity 1994;1(6):501-8.
1994: D J Lenschow; Anne I Sperling; M P Cooke; Gordon J Freeman; L Rhee; D C Decker; G Gray; Lee M Nadler; Christopher C Goodnow; Jeffrey A Bluestone
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):1990-7.
1994: D M Smith; Jeffrey A Bluestone; D R Jeyarajah; M H Newberg; Victor H Engelhard; J Richard Thistlethwaite; E Steve Woodle
Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1054-67.
1994: T L Walunas; D J Lenschow; C Y Bakker; P S Linsley; G J Freeman; J M Green; Craig Thompson; Jeffrey A Bluestone
CTLA-4 can function as a negative regulator of T cell activation.
Immunity 1994;1(5):405-13.
1994: Maria-Luisa Alegre; H A Sattar; KC Herold; J Smith; Mark Tepper; Jeffrey A Bluestone
Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model.
Transplantation 1994;57(12):1786-94.
1994: Maria-Luisa Alegre; L J Peterson; Danlin Xu; H A Sattar; D R Jeyarajah; K Kowalkowski; J Richard Thistlethwaite; Robert A Zivin; Linda Jolliffe; Jeffrey A Bluestone
A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Transplantation 1994;57(11):1537-43.
1994: R M Stack; D J Lenschow; GS Gray; Jeffrey A Bluestone; F W Fitch
IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5723-33.
1994: Roger Sciammas; R M Johnson; Anne I Sperling; W Brady; P S Linsley; Patricia G Spear; F W Fitch; Jeffrey A Bluestone
Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5392-7.
1994: Y Zeng; M A Torres; J Richard Thistlethwaite; A Montag; Jeffrey A Bluestone
Prolongation of human pancreatic islet xenografts by pretreatment of islets with anti-human ICAM-1 monoclonal antibody.
Transplantation proceedings 1994;26(3):1120.
1994: M Rubin; Jeffrey A Bluestone; K A Newell; A Prokhorova; Margalit B Mokyr
Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3522-9.
1994: Y Tatsumi; Dominick DeLuca; R Q Cron; Jeffrey A Bluestone
Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture.
Thymus 1994;23(3-4):131-53.
1994: Roger Sciammas; Y Tatsumi; Anne I Sperling; K Arunan; Jeffrey A Bluestone
TCR gamma delta cells: mysterious cells of the immune system.
Immunologic research 1994;13(4):268-79.
1993: D Qian; Anne I Sperling; D W Lancki; Y Tatsumi; Terrence Anthony Barrett; Jeffrey A Bluestone; F W Fitch
The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11875-9.
1993: Anne I Sperling; Peter Linsley; Terrence Anthony Barrett; Jeffrey A Bluestone
CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6043-50.
1993: D J Lenschow; G H Su; L A Zuckerman; N Nabavi; C L Jellis; GS Gray; Jim Miller; Jeffrey A Bluestone
Expression and functional significance of an additional ligand for CTLA-4.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11054-8.
1993: Margalit B Mokyr; M Rubin; K A Newell; A Prokhorova; Jeffrey A Bluestone
Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4838-46.
1993: Jeffrey A Bluestone; A Kaliyaperumal; S Jameson; S Miller; R Dick
Peptide-induced changes in class I heavy chains alter allorecognition.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):3943-53.
1993: A L Dent; L A Matis; Jeffrey A Bluestone; Stephen M Hedrick
Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes.
European journal of immunology 1993;23(10):2482-7.
1993: D J Lenschow; Jeffrey A Bluestone
T cell co-stimulation and in vivo tolerance.
Current opinion in immunology 1993;5(5):747-52.
1993: Y Tatsumi; J C Pena; L Matis; Dominick DeLuca; Jeffrey A Bluestone
Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3030-41.
1993: Terrence Anthony Barrett; Y Tatsumi; Jeffrey A Bluestone
Tolerance of T cell receptor gamma/delta cells in the intestine.
The Journal of experimental medicine 1993;177(6):1755-62.
1993: Jeffrey A Bluestone; D Bruce; L Peterson; J Richard Thistlethwaite; M Josephson; Y Zeng; P S Linsley; D J Lenschow
Immunosuppressive effects of anti-CD3 MAb and soluble co-stimulatory molecules.
Transplantation proceedings 1993;25(1 Pt 1):546-7.
1993: Y Zeng; Jeffrey A Bluestone; Suzanne Ildstad; M A Torres; A G Montag; R J Thistlethwaite
Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat-->B6 mouse).
Transplantation proceedings 1993;25(1 Pt 1):438-9.
1992: Jeffrey A Bluestone; S Jameson; S Miller; R Dick
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition.
The Journal of experimental medicine 1992;176(6):1757-61.
1992: Anne I Sperling; R Q Cron; D C Decker; D A Stern; Jeffrey A Bluestone
Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3200-7.
1992: Terrence Anthony Barrett; Thomas F Gajewski; D Danielpour; Eugene B Chang; Ken Beagley; Jeffrey A Bluestone
Differential function of intestinal intraepithelial lymphocyte subsets.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1124-30.
1992: D J Lenschow; Y Zeng; J Richard Thistlethwaite; A Montag; W Brady; M G Gibson; Peter Linsley; Jeffrey A Bluestone
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg.
Science (New York, N.Y.) 1992;257(5071):789-92.
1992: Maria-Luisa Alegre; A M Collins; V L Pulito; R A Brosius; W C Olson; Robert A Zivin; R Knowles; J Richard Thistlethwaite; Linda Jolliffe; Jeffrey A Bluestone
Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3461-8.
1992: E Steve Woodle; J Richard Thistlethwaite; Linda Jolliffe; Robert A Zivin; A Collins; J R Adair; M Bodmer; D Athwal; Maria-Luisa Alegre; Jeffrey A Bluestone
Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2756-63.
1992: Jeffrey A Bluestone; C Spencer; R Hirsch
The T cell receptor in autoimmune diseases.
The Journal of rheumatology. Supplement 1992;33():75-7.
1992: KC Herold; Jeffrey A Bluestone; A G Montag; A Parihar; A Wiegner; R E Gress; R Hirsch
Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody.
Diabetes 1992;41(3):385-91.
1992: R M Johnson; D W Lancki; Anne I Sperling; R F Dick; Patricia G Spear; F W Fitch; Jeffrey A Bluestone
A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):983-8.
1992: Terrence Anthony Barrett; M L Delvy; D M Kennedy; L Lefrancois; L A Matis; A L Dent; S M Hedrick; Jeffrey A Bluestone
Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue.
The Journal of experimental medicine 1992;175(1):65-70.
1991: Kenneth A Newell; J D Ellenhorn; R Hirsch; Jeffrey A Bluestone
Immunopotentiation of anti-viral and anti-tumor immune responses using anti-T cell receptor antibodies and mitogens.
Annals of the New York Academy of Sciences 1991;636():279-87.
1991: E Steve Woodle; J Richard Thistlethwaite; I A Ghobrial; Linda Jolliffe; Frank P Stuart; Jeffrey A Bluestone
OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release.
Transplantation 1991;52(2):354-60.
1991: E Steve Woodle; J Richard Thistlethwaite; Linda Jolliffe; A J Fucello; Frank P Stuart; Jeffrey A Bluestone
Anti-CD3 monoclonal antibody therapy. An approach toward optimization by in vitro analysis of new anti-CD3 antibodies.
Transplantation 1991;52(2):361-8.
1991: Jeffrey A Bluestone; R Q Cron; Terrence Anthony Barrett; B Houlden; Anne I Sperling; A Dent; S Hedrick; Barbara L Rellahan; L A Matis
Repertoire development and ligand specificity of murine TCR gamma delta cells.
Immunological reviews 1991;120():5-33.
1991: Kenneth A Newell; J D Ellenhorn; David S Bruce; Jeffrey A Bluestone
In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):1074-8.
1991: E Steve Woodle; J Richard Thistlethwaite; Linda Jolliffe; I Ghobrial; A J Fuccello; Frank P Stuart; Jeffrey A Bluestone
T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies.
Transplantation proceedings 1991;23(1 Pt 1):81-2.
1991: Barbara L Rellahan; Jeffrey A Bluestone; B A Houlden; M M Cotterman; L A Matis
Junctional sequences influence the specificity of gamma/delta T cell receptors.
The Journal of experimental medicine 1991;173(2):503-6.
1991: B A Houlden; S M Widacki; Jeffrey A Bluestone
Signal transduction through class I MHC by a monoclonal antibody that detects multiple murine and human class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):425-30.
1991: Terrence Anthony Barrett; S M Hedrick; A L Dent; M L Delvy; D M Kennedy; L A Matis; Jeffrey A Bluestone
Control of self-reactivity in the intestine.
Immunologic research 1991;10(3-4):341-8.
1991: Jeffrey A Bluestone; R Q Cron; Barbara L Rellahan; L A Matis
Ligand specificity and repertoire development of murine TCR gamma delta cells.
Current topics in microbiology and immunology 1991;173():133-9.
1990: J D Ellenhorn; E Steve Woodle; J Richard Thistlethwaite; Jeffrey A Bluestone
T lymphocyte activation following OKT3 treatment.
Current surgery 1990;47(6):458-9.
1990: J D Ellenhorn; E Steve Woodle; I Ghobreal; J Richard Thistlethwaite; Jeffrey A Bluestone
Activation of human T cells in vivo following treatment of transplant recipients with OKT3.
Transplantation 1990;50(4):608-12.
1990: A Ezquerra; R Q Cron; T J McConnell; R B Valas; Jeffrey A Bluestone; John E Coligan
T cell receptor delta-gene expression and diversity in the mouse spleen.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1311-7.
1990: Jeffrey A Bluestone; L A Matis
Are TCR alpha beta cells and TCR gamma delta cells that different?
Research in immunology 1990;141(7):606-10.
1990: J D Ellenhorn; Hans Schreiber; Jeffrey A Bluestone
Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2840-6.
1990: A L Dent; L A Matis; Farideh Hooshmand; S M Widacki; Jeffrey A Bluestone; Stephen M Hedrick
Self-reactive gamma delta T cells are eliminated in the thymus.
Nature 1990;343(6260):714-9.
1990: R Q Cron; John E Coligan; Jeffrey A Bluestone
Polymorphisms and diversity of T-cell receptor-gamma proteins expressed in mouse spleen.
Immunogenetics 1990;31(4):220-8.
1989: R Q Cron; A Ezquerra; John E Coligan; B A Houlden; Jeffrey A Bluestone; W L Maloy
Identification of distinct T cell receptor (TCR)-gamma delta heterodimers using an anti-TCR-gamma variable region serum.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3769-75.
1989: L A Matis; A M Fry; R Q Cron; M M Cotterman; R F Dick; Jeffrey A Bluestone
Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer.
Science (New York, N.Y.) 1989;245(4919):746-9.
1989: R Q Cron; Thomas F Gajewski; S O Sharrow; F W Fitch; L A Matis; Jeffrey A Bluestone
Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3754-62.
1989: Jeffrey A Bluestone; L A Matis
TCR gamma delta cells--minor redundant T cell subset or specialized immune system component?
Journal of immunology (Baltimore, Md. : 1950) 1989;142(6):1785-8.
1989: J D Ellenhorn; R Hirsch; J P Hartley; Jeffrey A Bluestone
Dose-dependent activation of murine T cells following in vivo administration of anti-murine CD3.
Transplantation proceedings 1989;21(1 Pt 1):1013-4.
1989: B A Houlden; L A Matis; R Q Cron; S M Widacki; G D Brown; C Pampeno; D Meruelo; Jeffrey A Bluestone
A TCR gamma delta cell recognizing a novel TL-encoded gene product.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():45-55.
1989: Brian D Evavold; A Yokoyama; R Hirsch; Jeffrey A Bluestone; J Quintans
T helper 2 (Th2) but not Th1 clones co-stimulate resting T cells in the presence of anti-CD3 monoclonal antibody.
International immunology 1989;1(4):443-9.
1988: B A Houlden; R Q Cron; John E Coligan; Jeffrey A Bluestone
Systematic development of distinct T cell receptor-gamma delta T cell subsets during fetal ontogeny.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3753-9.
1988: Jeffrey A Bluestone; R Q Cron; M Cotterman; B A Houlden; L A Matis
Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.
The Journal of experimental medicine 1988;168(5):1899-916.
1988: J D Ellenhorn; R Hirsch; Hans Schreiber; Jeffrey A Bluestone
In vivo administration of anti-CD3 prevents malignant progressor tumor growth.
Science (New York, N.Y.) 1988;242(4878):569-71.
1987: L A Matis; R Cron; Jeffrey A Bluestone
Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes.
Nature 1987;330(6145):262-4.