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Jeffrey Bluestone

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Physiology

Anatomy

T-Lymphocytes

Chemicals & Drugs

Disorders

Type 1 Diabetes Mellitus

Concepts & Ideas

T-Lymphocyte Subsets

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Publications

TOP 3
Bluestone Jeffrey A; Mackay Charles R; O'Shea John J; Stockinger Brigitta
The functional plasticity of T cell subsets.
Penaranda Cristina; Bluestone Jeffrey A
Is antigen specificity of autoreactive T cells the key to islet entry?
Esensten Jonathan H; Wofsy David; Bluestone Jeffrey A
Regulatory T cells as therapeutic targets in rheumatoid arthritis.

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All Publications

2009: Bluestone Jeffrey A; Mackay Charles R; O'Shea John J; Stockinger Brigitta
The functional plasticity of T cell subsets.
Nature reviews. Immunology 2009;9(11):811-6.
2009: Penaranda Cristina; Bluestone Jeffrey A
Is antigen specificity of autoreactive T cells the key to islet entry?
Immunity 2009;31(4):534-6.
2009: Esensten Jonathan H; Wofsy David; Bluestone Jeffrey A
Regulatory T cells as therapeutic targets in rheumatoid arthritis.
Nature reviews. Rheumatology 2009;5(10):560-5.
2009: Zhou Xuyu; Bailey-Bucktrout Samantha L; Jeker Lukas T; Penaranda Cristina; Martínez-Llordella Marc; Ashby Meredith; Nakayama Maki; Rosenthal Wendy; Bluestone Jeffrey A
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo.
Nature immunology 2009;10(9):1000-7.
2009: Herold Kevan C; Gitelman Stephen; Greenbaum Carla; Puck Jennifer; Hagopian William; Gottlieb Peter; Sayre Peter; Bianchine Peter; Wong Emelita; Seyfert-Margolis Vicki; Bourcier Kasia; Bluestone Jeffrey A;
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years.
Clinical immunology (Orlando, Fla.) 2009;132(2):166-73.
2009: Perruche Sylvain; Zhang Pin; Maruyama Takashi; Bluestone Jeffrey A; Saas Philippe; Chen WanJun
Lethal effect of CD3-specific antibody in mice deficient in TGF-beta1 by uncontrolled flu-like syndrome.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(2):953-61.
2009: Esensten Jonathan H; Lee Michael R; Glimcher Laurie H; Bluestone Jeffrey A
T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):75-82.
2009: Zhou Xuyu; Bailey-Bucktrout Samantha; Jeker Lukas T; Bluestone Jeffrey A
Plasticity of CD4(+) FoxP3(+) T cells.
Current opinion in immunology 2009;21(3):281-5.
2009: Bour-Jordan Hélène; Bluestone Jeffrey A
Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.
Immunological reviews 2009;229(1):41-66.
2009: Su Maureen A; Stenerson Matthew; Liu Weihong; Putnam Amy; Conte Felix; Bluestone Jeffrey A; Anderson Mark S
The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients.
Clinical immunology (Orlando, Fla.) 2009;131(1):139-44.
2009: Louvet Cédric; Kabre Beniwende G; Davini Dan W; Martinier Nicolas; Su Maureen A; DeVoss Jason J; Rosenthal Wendy L; Anderson Mark S; Bour-Jordan Hélène; Bluestone Jeffrey A
A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy.
The Journal of experimental medicine 2009;206(3):507-14.
2008: Louvet Cédric; Szot Gregory L; Lang Jiena; Lee Michael R; Martinier Nicolas; Bollag Gideon; Zhu Shirley; Weiss Arthur; Bluestone Jeffrey A
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(48):18895-900.
2008: Bluestone Jeffrey A; Tang Qizhi; Sedwick Caitlin E
T regulatory cells in autoimmune diabetes: past challenges, future prospects.
Journal of clinical immunology 2008;28(6):677-84.
2008: Bluestone J A; Liu W; Yabu J M; Laszik Z G; Putnam A; Belingheri M; Gross D M; Townsend R M; Vincenti F
The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(10):2086-96.
2008: Wen Li; Ley Ruth E; Volchkov Pavel Yu; Stranges Peter B; Avanesyan Lia; Stonebraker Austin C; Hu Changyun; Wong F Susan; Szot Gregory L; Bluestone Jeffrey A; Gordon Jeffrey I; Chervonsky Alexander V
Innate immunity and intestinal microbiota in the development of Type 1 diabetes.
Nature 2008;455(7216):1109-13.
2008: Zhou Xuyu; Jeker Lukas T; Fife Brian T; Zhu Shirley; Anderson Mark S; McManus Michael T; Bluestone Jeffrey A
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity.
The Journal of experimental medicine 2008;205(9):1983-91.
2008: Fife Brian T; Bluestone Jeffrey A
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways.
Immunological reviews 2008;224():166-82.
2008: Brusko Todd M; Putnam Amy L; Bluestone Jeffrey A
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities.
Immunological reviews 2008;223():371-90.
2008: Meagher Craig; Tang Qizhi; Fife Brian T; Bour-Jordan Helene; Wu Jenny; Pardoux Cecile; Bi Mingying; Melli Kristin; Bluestone Jeffrey A
Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7793-803.
2008: Tang Qizhi; Adams Jason Y; Penaranda Cristina; Melli Kristin; Piaggio Eliane; Sgouroudis Evridiki; Piccirillo Ciriaco A; Salomon Benoit L; Bluestone Jeffrey A
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction.
Immunity 2008;28(5):687-97.
2008: Perruche Sylvain; Zhang Pin; Liu Yongzhong; Saas Philippe; Bluestone Jeffrey A; Chen Wanjun
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells.
Nature medicine 2008;14(5):528-35.
2008: Cano David A; Rulifson Ingrid C; Heiser Patrick W; Swigart Lamorna B; Pelengaris Stella; German Mike; Evan Gerard I; Bluestone Jeffrey A; Hebrok Matthias
Regulated beta-cell regeneration in the adult mouse pancreas.
Diabetes 2008;57(4):958-66.
2008: Tang Qizhi; Bluestone Jeffrey A
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation.
Nature immunology 2008;9(3):239-44.
2007: Bour-Jordan Hélène; Bluestone Jeffrey A
B cell depletion: a novel therapy for autoimmune diabetes?
The Journal of clinical investigation 2007;117(12):3642-5.
2007: Sherry Nicole A; Chen Wei; Kushner Jake A; Glandt Mariela; Tang Qizhi; Tsai Sue; Santamaria Pere; Bluestone Jeffrey A; Brillantes Anne-Marie B; Herold Kevan C
Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells.
Endocrinology 2007;148(11):5136-44.
2007: Guleria Indira; Gubbels Bupp Melanie; Dada Shirine; Fife Brian; Tang Qizhi; Ansari Mohammed Javeed; Trikudanathan Subbulaxmi; Vadivel Nidyanandh; Fiorina Paolo; Yagita Hideo; Azuma Miyuki; Atkinson Mark; Bluestone Jeffrey A; Sayegh Mohamed H
Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Clinical immunology (Orlando, Fla.) 2007;125(1):16-25.
2007: Travis Mark A; Reizis Boris; Melton Andrew C; Masteller Emma; Tang Qizhi; Proctor John M; Wang Yanli; Bernstein Xin; Huang Xiaozhu; Reichardt Louis F; Bluestone Jeffrey A; Sheppard Dean
Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.
Nature 2007;449(7160):361-5.
2007: Bour-Jordan Hélène; Salomon Benoit L; Thompson Heather L; Santos Rex; Abbas Abul K; Bluestone Jeffrey A
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(2):1004-12.
2007: Kang S M; Tang Q; Bluestone J A
CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(6):1457-63.
2007: Chikuma Shunsuke; Bluestone Jeffrey A
Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.
European journal of immunology 2007;37(5):1285-9.
2007: Szot Gregory L; Koudria Pavel; Bluestone Jeffrey A
Transplantation of pancreatic islets into the kidney capsule of diabetic mice.
Journal of visualized experiments : JoVE 2007;(9):404.
2007: Szot Gregory L; Koudria Pavel; Bluestone Jeffrey A
Murine pancreatic islet isolation.
Journal of visualized experiments : JoVE 2007;(7):255.
2006: Bour-Jordan Helene; Bluestone Jeffrey A
Sensory neurons link the nervous system and autoimmune diabetes.
Cell 2006;127(6):1097-9.
2006: Fife Brian T; Guleria Indira; Gubbels Bupp Melanie; Eagar Todd N; Tang Qizhi; Bour-Jordan Helene; Yagita Hideo; Azuma Miyuki; Sayegh Mohamed H; Bluestone Jeffrey A
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway.
The Journal of experimental medicine 2006;203(12):2737-47.
2006: Seyfert-Margolis Vicki; Gisler Trang D; Asare Adam L; Wang Richard S; Dosch H Michael; Brooks-Worrell Barbara; Eisenbarth George S; Palmer Jerry P; Greenbaum Carla J; Gitelman Stephen E; Nepom Gerald T; Bluestone Jeffrey A; Herold Kevan C
Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study.
Diabetes 2006;55(9):2588-94.
2006: Tang Qizhi; Bluestone Jeffrey A
Regulatory T-cell physiology and application to treat autoimmunity.
Immunological reviews 2006;212():217-37.
2006: Fife Brian T; Griffin Matthew D; Abbas Abul K; Locksley Richard M; Bluestone Jeffrey A
Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
The Journal of clinical investigation 2006;116(8):2252-61.
2006: Scalapino Kenneth J; Tang Qizhi; Bluestone Jeffrey A; Bonyhadi Mark L; Daikh David I
Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1451-9.
2006: Liu Weihong; Putnam Amy L; Xu-Yu Zhou; Szot Gregory L; Lee Michael R; Zhu Shirley; Gottlieb Peter A; Kapranov Philipp; Gingeras Thomas R; Fazekas de St Groth Barbara; Clayberger Carol; Soper David M; Ziegler Steven F; Bluestone Jeffrey A
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.
The Journal of experimental medicine 2006;203(7):1701-11.
2006: Masteller Emma L; Tang Qizhi; Bluestone Jeffrey A
Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential.
Seminars in immunology 2006;18(2):103-10.
2006: Bluestone Jeffrey A; St Clair E William; Turka Laurence A
CTLA4Ig: bridging the basic immunology with clinical application.
Immunity 2006;24(3):233-8.
2006: Tang Qizhi; Adams Jason Y; Tooley Aaron J; Bi Mingying; Fife Brian T; Serra Pau; Santamaria Pere; Locksley Richard M; Krummel Matthew F; Bluestone Jeffrey A
Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice.
Nature immunology 2006;7(1):83-92.
2005: Bluestone Jeffrey A; Tang Qizhi
How do CD4+CD25+ regulatory T cells control autoimmunity?
Current opinion in immunology 2005;17(6):638-42.
2005: Knoechel Birgit; Lohr Jens; Kahn Estelle; Bluestone Jeffrey A; Abbas Abul K
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
The Journal of experimental medicine 2005;202(10):1375-86.
2005: Bour-Jordan Hélène; Thompson Heather L; Bluestone Jeffrey A
Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5649-55.
2005: Bisikirska Brygida; Colgan John; Luban Jeremy; Bluestone Jeffrey A; Herold Kevan C
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.
The Journal of clinical investigation 2005;115(10):2904-13.
2005: Chen Wei; Bluestone Jeffrey A; Herold Kevan C
Achieving antigen-specific tolerance in diabetes: regulating specifically.
International reviews of immunology 2005;24(5-6):287-305.
2005: Dai Yang D; Jensen Kent P; Lehuen Agnes; Masteller Emma L; Bluestone Jeffrey A; Wilson Darcy B; Sercarz Eli E
A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3621-7.
2005: Masteller Emma L; Warner Matthew R; Tang Qizhi; Tarbell Kristin V; McDevitt Hugh; Bluestone Jeffrey A
Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):3053-9.
2005: Chikuma Shunsuke; Abbas Abul K; Bluestone Jeffrey A
B7-independent inhibition of T cells by CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(1):177-81.
2005: Herold Kevan C; Gitelman Stephen E; Masharani Umesh; Hagopian William; Bisikirska Brygida; Donaldson David; Rother Kristina; Diamond Beverly; Harlan David M; Bluestone Jeffrey A
A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
Diabetes 2005;54(6):1763-9.
2005: Bezbradica Jelena S; Stanic Aleksandar K; Matsuki Naoto; Bour-Jordan Helene; Bluestone Jeffrey A; Thomas James W; Unutmaz Derya; Van Kaer Luc; Joyce Sebastian
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4696-705.
2005: Kohm Adam P; Williams Julie S; Bickford Allison L; McMahon Jeffrey S; Chatenoud Lucienne; Bach Jean-François; Bluestone Jeffrey A; Miller Stephen D
Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(8):4525-34.
2005: Bluestone Jeffrey A
Regulatory T-cell therapy: is it ready for the clinic?
Nature reviews. Immunology 2005;5(4):343-9.
2005: Anderson Mark S; Bluestone Jeffrey A
The NOD mouse: a model of immune dysregulation.
Annual review of immunology 2005;23():447-85.
2004: Tang Qizhi; Boden Elisa K; Henriksen Kammi J; Bour-Jordan Helene; Bi Mingying; Bluestone Jeffrey A
Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function.
European journal of immunology 2004;34(11):2996-3005.
2004: Bour-Jordan Hélène; Salomon Benoît L; Thompson Heather L; Szot Gregory L; Bernhard Matthew R; Bluestone Jeffrey A
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.
The Journal of clinical investigation 2004;114(7):979-87.
2004: Judkowski Valeria; Rodriguez Enrique; Pinilla Clemencia; Masteller Emma; Bluestone Jeffrey A; Sarvetnick Nora; Wilson Darcy B
Peptide specific amelioration of T cell mediated pathogenesis in murine type 1 diabetes.
Clinical immunology (Orlando, Fla.) 2004;113(1):29-37.
2004: Bluestone Jeffrey A; Tang Qizhi
Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101 Suppl 2():14622-6.
2004: Ogasawara Kouetsu; Hamerman Jessica A; Ehrlich Lauren R; Bour-Jordan Helene; Santamaria Pere; Bluestone Jeffrey A; Lanier Lewis L
NKG2D blockade prevents autoimmune diabetes in NOD mice.
Immunity 2004;20(6):757-67.
2004: Eagar Todd N; Turley Danielle M; Padilla Josette; Karandikar Nitin J; Tan Litjen; Bluestone Jeffrey A; Miller Stephen D
CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(12):7442-50.
2004: Tang Qizhi; Henriksen Kammi J; Bi Mingying; Finger Erik B; Szot Greg; Ye Jianqin; Masteller Emma L; McDevitt Hugh; Bonyhadi Mark; Bluestone Jeffrey A
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
The Journal of experimental medicine 2004;199(11):1455-65.
2004: Eagar Todd N; Tang Qizhi; Wolfe Michael; He Yiping; Pear Warren S; Bluestone Jeffrey A
Notch 1 signaling regulates peripheral T cell activation.
Immunity 2004;20(4):407-15.
2004: Steele Chynna; Hagopian William A; Gitelman Stephen; Masharani Umesh; Cavaghan Melissa; Rother Kristina I; Donaldson David; Harlan David M; Bluestone Jeffrey; Herold Kevan C
Insulin secretion in type 1 diabetes.
Diabetes 2004;53(2):426-33.
2004: Jovasevic Vladimir M; Gorelik Leonid; Bluestone Jeffrey A; Mokyr Margalit B
Importance of IL-10 for CTLA-4-mediated inhibition of tumor-eradicating immunity.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1449-54.
2004: Stock Peter G; Bluestone Jeffrey A
Beta-cell replacement for type I diabetes.
Annual review of medicine 2004;55():133-56.
2003: Masteller Emma L; Warner Matthew R; Ferlin Walter; Judkowski Valeria; Wilson Darcy; Glaichenhaus Nicolas; Bluestone Jeffrey A
Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5587-95.
2003: Tang Qizhi; Henriksen Kammi J; Boden Elisa K; Tooley Aaron J; Ye Jianqin; Subudhi Sumit K; Zheng Xin X; Strom Terry B; Bluestone Jeffrey A
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(7):3348-52.
2003: Matthews Jeffrey B; Ramos Eleanor; Bluestone Jeffrey A
Clinical trials of transplant tolerance: slow but steady progress.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):794-803.
2003: Bluestone Jeffrey A; Abbas Abul K
Natural versus adaptive regulatory T cells.
Nature reviews. Immunology 2003;3(3):253-7.
2003: Starwalt Scott E; Masteller Emma L; Bluestone Jeffrey A; Kranz David M
Directed evolution of a single-chain class II MHC product by yeast display.
Protein engineering 2003;16(2):147-56.
2003: Herold Kevan C; Burton Joshua B; Francois Fleur; Poumian-Ruiz Ena; Glandt Mariela; Bluestone Jeffrey A
Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).
The Journal of clinical investigation 2003;111(3):409-18.
2003: Tang Qizhi; Smith Judy A; Szot Greg L; Zhou Ping; Alegre Maria-Luisa; Henriksen Kammi J; Thompson Craig B; Bluestone Jeffrey A
CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(3):1510-6.
2003: Bour-Jordan Hélène; Grogan Jane L; Tang Qizhi; Auger Julie A; Locksley Richard M; Bluestone Jeffrey A
CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.
Nature immunology 2003;4(2):182-8.
2003: Ogasawara Kouetsu; Hamerman Jessica A; Hsin Honor; Chikuma Shunsuke; Bour-Jordan Helene; Chen Taian; Pertel Thomas; Carnaud Claude; Bluestone Jeffrey A; Lanier Lewis L
Impairment of NK cell function by NKG2D modulation in NOD mice.
Immunity 2003;18(1):41-51.
2003: Boden Elisa; Tang Qizhi; Bour-Jordan Helene; Bluestone Jeffrey A
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.
Novartis Foundation symposium 2003;252():55-63; discussion 63-6, 106-14.
2002: Masteller Emma L; Bluestone Jeffrey A
Immunotherapy of insulin-dependent diabetes mellitus.
Current opinion in immunology 2002;14(5):652-9.
2002: Utset Tammy O; Auger Julie A; Peace Donna; Zivin Robert A; Xu Danlin; Jolliffe Linda; Alegre Maria-Luisa; Bluestone Jeffrey A; Clark Marcus R
Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial.
The Journal of rheumatology 2002;29(9):1907-13.
2002: Chikuma Shunsuke; Bluestone Jeffrey A
CTLA-4: acting at the synapse.
Molecular interventions 2002;2(4):205-8.
2002: Rulifson Ingrid C; Szot Gregory L; Palmer Ed; Bluestone Jeffrey A
Inability to induce tolerance through direct antigen presentation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(6):510-9.
2002: Hwang Kwang Woo; Sweatt William B; Brown Ian E; Blank Christian; Gajewski Thomas F; Bluestone Jeffrey A; Alegre Maria-Luisa
Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(2):633-7.
2002: Herold Kevan C; Hagopian William; Auger Julie A; Poumian-Ruiz Ena; Taylor Lesley; Donaldson David; Gitelman Stephen E; Harlan David M; Xu Danlin; Zivin Robert A; Bluestone Jeffrey A
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus.
The New England journal of medicine 2002;346(22):1692-8.
2002: Tang Qizhi; Subudhi Sumit K; Henriksen Kammi J; Long Catherine G; Vives Franklin; Bluestone Jeffrey A
The Src family kinase Fyn mediates signals induced by TCR antagonists.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4480-7.
2002: Eagar Todd N; Karandikar Nitin J; Bluestone Jeffrey A; Miller Stephen D
The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance.
European journal of immunology 2002;32(4):972-81.
2001: Salomon B; Rhee L; Bour-Jordan H; Hsin H; Montag A; Soliven B; Arcella J; Girvin A M; Padilla J; Miller S D; Bluestone J A
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice.
The Journal of experimental medicine 2001;194(5):677-84.
2001: O'Herrin S M; Slansky J E; Tang Q; Markiewicz M A; Gajewski T F; Pardoll D M; Schneck J P; Bluestone J A
Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2555-60.
2001: Tesciuba A G; Subudhi S; Rother R P; Faas S J; Frantz A M; Elliot D; Weinstock J; Matis L A; Bluestone J A; Sperling A I
Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1996-2003.
2001: Sperling A I; Bluestone J A
ICOS costimulation: It's not just for TH2 cells anymore.
Nature immunology 2001;2(7):573-4.
2001: Wu Q; Salomon B; Chen M; Wang Y; Hoffman L M; Bluestone J A; Fu Y X
Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor.
The Journal of experimental medicine 2001;193(11):1327-32.
2001: Donepudi M; Raychaudhuri P; Bluestone J A; Mokyr M B
Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(11):6491-9.
2001: Szot G L; Zhou P; Rulifson I; Wang J; Guo Z; Kim O; Newel K A; Thistlethwaite J R; Bluestone J A; Alegre M L
Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2001;1(1):38-46.
2001: Zhou P; Szot G; Guo Z; Kim O; He G; Wang J; Grusby M; Newell K; Thistlethwaite J; Bluestone J; Alegre M
Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Transplantation proceedings 2001;33(1-2):214-6.
2001: Alegre M; Fallarino F; Zhou P; Frauwirth K; Thistlethwaite J; Newell K; Gajewski T; Bluestone J
Transplantation and the CD28/CTLA4/B7 pathway.
Transplantation proceedings 2001;33(1-2):209-11.
2001: Griffin M D; Holman P O; Tang Q; Ashourian N; Korthäuer U; Kranz D M; Bluestone J A
Development and applications of surface-linked single chain antibodies against T-cell antigens.
Journal of immunological methods 2001;248(1-2):77-90.
2001: Salomon B; Bluestone J A
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.
Annual review of immunology 2001;19():225-52.
2000: Zhou P; Szot G L; Guo Z; Kim O; He G; Wang J; Grusby M J; Newell K A; Thistlethwaite J R; Bluestone J A; Alegre M L
Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5580-7.
2000: Bluestone J A; Matthews J B; Krensky A M
The immune tolerance network: the "Holy Grail" comes to the clinic.
Journal of the American Society of Nephrology : JASN 2000;11(11):2141-6.
2000: Karandikar N J; Eagar T N; Vanderlugt C L; Bluestone J A; Miller S D
CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis.
Journal of neuroimmunology 2000;109(2):173-80.
2000: Neville K L; Dal Canto M C; Bluestone J A; Miller S D
CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.
Journal of virology 2000;74(18):8349-57.
2000: Sojka D K; Donepudi M; Bluestone J A; Mokyr M B
Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(12):6230-6.
2000: Griffin M D; Hong D K; Holman P O; Lee K M; Whitters M J; O'Herrin S M; Fallarino F; Collins M; Segal D M; Gajewski T F; Kranz D M; Bluestone J A
Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4433-42.
2000: Salomon B; Lenschow D J; Rhee L; Ashourian N; Singh B; Sharpe A; Bluestone J A
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.
Immunity 2000;12(4):431-40.
2000: Szot G L; Zhou P; Sharpe A H; He G; Kim O; Newell K A; Bluestone J A; Thistlethwaite J R
Absence of host B7 expression is sufficient for long-term murine vascularized heart allograft survival.
Transplantation 2000;69(5):904-9.
2000: Xu D; Alegre M L; Varga S S; Rothermel A L; Collins A M; Pulito V L; Hanna L S; Dolan K P; Parren P W; Bluestone J A; Jolliffe L K; Zivin R A
In vitro characterization of five humanized OKT3 effector function variant antibodies.
Cellular immunology 2000;200(1):16-26.
2000: Vanderlugt C L; Neville K L; Nikcevich K M; Eagar T N; Bluestone J A; Miller S D
Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):670-8.
2000: Korthäuer U; Nagel W; Davis E M; Le Beau M M; Menon R S; Mitchell E O; Kozak C A; Kolanus W; Bluestone J A
Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):308-18.
2000: Girvin A M; Dal Canto M C; Rhee L; Salomon B; Sharpe A; Bluestone J A; Miller S D
A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):136-43.
1999: Rajagopal K; Sommers C L; Decker D C; Mitchell E O; Korthauer U; Sperling A I; Kozak C A; Love P E; Bluestone J A
RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation.
The Journal of experimental medicine 1999;190(11):1657-68.
1999: Mathur M; Herrmann K; Qin Y; Gulmen F; Li X; Krimins R; Weinstock J; Elliott D; Bluestone J A; Padrid P
CD28 interactions with either CD80 or CD86 are sufficient to induce allergic airway inflammation in mice.
American journal of respiratory cell and molecular biology 1999;21(4):498-509.
1999: Woodle E S; Xu D; Zivin R A; Auger J; Charette J; O'Laughlin R; Peace D; Jollife L K; Haverty T; Bluestone J A; Thistlethwaite J R
Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection.
Transplantation 1999;68(5):608-16.
1999: Newell K A; He G; Guo Z; Kim O; Szot G L; Rulifson I; Zhou P; Hart J; Thistlethwaite J R; Bluestone J A
Cutting edge: blockade of the CD28/B7 costimulatory pathway inhibits intestinal allograft rejection mediated by CD4+ but not CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2358-62.
1999: Theriault B R; Thistlethwaite J R; Levisetti M G; Wardrip C L; Szot G; Bruce D S; Rilo H; Li X; Gray G S; Bluestone J A; Padrid P A
Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis).
Transplantation 1999;68(3):331-7.
1999: Richards J; Auger J; Peace D; Gale D; Michel J; Koons A; Haverty T; Zivin R; Jolliffe L; Bluestone J A
Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.
Cancer research 1999;59(9):2096-101.
1999: Khattri R; Auger J A; Griffin M D; Sharpe A H; Bluestone J A
Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5784-91.
1999: La Motte R N; Sharpe A H; Bluestone J A; Mokyr M B
Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(8):4817-23.
1999: Sciammas R; Bluestone J A
TCRgammadelta cells and viruses.
Microbes and infection / Institut Pasteur 1999;1(3):203-12.
1999: Chuang E; Lee K M; Robbins M D; Duerr J M; Alegre M L; Hambor J E; Neveu M J; Bluestone J A; Thompson C B
Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1270-7.
1999: Kaufman K A; Bowen J A; Tsai A F; Bluestone J A; Hunt J S; Ober C
The CTLA-4 gene is expressed in placental fibroblasts.
Molecular human reproduction 1999;5(1):84-7.
1998: La Motte R N; Sharpe A H; Bluestone J A; Mokyr M B
Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6552-8.
1998: Lee K M; Chuang E; Griffin M; Khattri R; Hong D K; Zhang W; Straus D; Samelson L E; Thompson C B; Bluestone J A
Molecular basis of T cell inactivation by CTLA-4.
Science (New York, N.Y.) 1998;282(5397):2263-6.
1998: Mokyr M B; Kalinichenko T; Gorelik L; Bluestone J A
Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice.
Cancer research 1998;58(23):5301-4.
1998: Sciammas R; Bluestone J A
HSV-1 glycoprotein I-reactive TCR gamma delta cells directly recognize the peptide backbone in a conformationally dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5187-92.
1998: Salomon B; Bluestone J A
LFA-1 interaction with ICAM-1 and ICAM-2 regulates Th2 cytokine production.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5138-42.
1998: Bluestone J A
Cell fate in the immune system: decisions, decisions, decisions.
Immunological reviews 1998;165():5-12.
1998: Vanderlugt C L; Begolka W S; Neville K L; Katz-Levy Y; Howard L M; Eagar T N; Bluestone J A; Miller S D
The functional significance of epitope spreading and its regulation by co-stimulatory molecules.
Immunological reviews 1998;164():63-72.
1998: Karandikar N J; Vanderlugt C L; Bluestone J A; Miller S D
Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease.
Journal of neuroimmunology 1998;89(1-2):10-8.
1998: Karandikar N J; Vanderlugt C L; Eagar T; Tan L; Bluestone J A; Miller S D
Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(1):192-9.
1998: Woodle E S; Bluestone J A; Zivin R A; Jolliffe L K; Auger J; Xu D; Thistlethwaite J R
Humanized, nonmitogenic OKT3 antibody, huOKT3 gamma(Ala-Ala): initial clinical experience.
Transplantation proceedings 1998;30(4):1369-70.
1998: Smith J A; Tang Q; Bluestone J A
Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(10):4841-9.
1998: Walunas T L; Bluestone J A
CTLA-4 regulates tolerance induction and T cell differentiation in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(8):3855-60.
1998: Padrid P A; Mathur M; Li X; Herrmann K; Qin Y; Cattamanchi A; Weinstock J; Elliott D; Sperling A I; Bluestone J A
CTLA4Ig inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Th1/Th2 subsets in a murine model of asthma.
American journal of respiratory cell and molecular biology 1998;18(4):453-62.
1998: Mokyr M B; Kalinichenko T V; Gorelik L; Bluestone J A
Importance of the B7-2 molecule for low dose melphalan-induced acquisition of tumor-eradicating immunity by mice bearing a large MOPC-315 tumor.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1866-74.
1997: Levisetti M G; Padrid P A; Szot G L; Mittal N; Meehan S M; Wardrip C L; Gray G S; Bruce D S; Thistlethwaite J R; Bluestone J A
Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5187-91.
1997: Vanderlugt C L; Karandikar N J; Lenschow D J; Dal Canto M C; Bluestone J A; Miller S D
Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE.
Journal of neuroimmunology 1997;79(2):113-8.
1997: Herold K C; Lu J; Rulifson I; Vezys V; Taub D; Grusby M J; Bluestone J A
Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4150-3.
1997: Smith J A; Bluestone J A
T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs.
Current opinion in immunology 1997;9(5):648-54.
1997: Wick M; Dubey P; Koeppen H; Siegel C T; Fields P E; Chen L; Bluestone J A; Schreiber H
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
The Journal of experimental medicine 1997;186(2):229-38.
1997: Sperling A I; Decker D C; DiPaolo R J; Stern D A; Shum A; Bluestone J A
Selective expansion of Vgamma2-Vdelta7 TCR gammadelta cells in C57BL/6 mice is postnatal and extrathymic.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(1):86-91.
1997: Sciammas R; Kodukula P; Tang Q; Hendricks R L; Bluestone J A
T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis.
The Journal of experimental medicine 1997;185(11):1969-75.
1997: Smith J A; Tso J Y; Clark M R; Cole M S; Bluestone J A
Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy.
The Journal of experimental medicine 1997;185(8):1413-22.
1997: Woodle E S; Smith D M; Bluestone J A; Kirkman W M; Green D R; Skowronski E W
Anti-human class I MHC antibodies induce apoptosis by a pathway that is distinct from the Fas antigen-mediated pathway.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2156-64.
1997: Bluestone J A
Is CTLA-4 a master switch for peripheral T cell tolerance?
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):1989-93.
1997: Woodle E S; Smith D M; Bluestone J A; Green D R; Skowronski E W
Class I MHC mediates programmed cell death in a Fas-independent manner.
Transplantation proceedings 1997;29(1-2):1101.
1997: Herold K G; Lenschow D J; Bluestone J A
CD28/B7 regulation of autoimmune diabetes.
Immunologic research 1997;16(1):71-84.
1997: Herold K C; Vezys V; Koons A; Lenschow D; Thompson C; Bluestone J A
CD28/B7 costimulation regulates autoimmune diabetes induced with multiple low doses of streptozotocin.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):984-91.
1997: Rulifson I C; Sperling A I; Fields P E; Fitch F W; Bluestone J A
CD28 costimulation promotes the production of Th2 cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):658-65.
1996: Sperling A I; Auger J A; Ehst B D; Rulifson I C; Thompson C B; Bluestone J A
CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(9):3909-17.
1996: Sperling A I; Bluestone J A
The complexities of T-cell co-stimulation: CD28 and beyond.
Immunological reviews 1996;153():155-82.
1996: Lenschow D J; Herold K C; Rhee L; Patel B; Koons A; Qin H Y; Fuchs E; Singh B; Thompson C B; Bluestone J A
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes.
Immunity 1996;5(3):285-93.
1996: Khattri R; Sperling A I; Qian D; Fitch F W; Shores E W; Love P E; Bluestone J A
TCR-gamma delta cells in CD3 zeta-deficient mice contain Fc epsilon RI gamma in the receptor complex but are specifically unresponsive to antigen.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(6):2320-7.
1996: Karandikar N J; Vanderlugt C L; Walunas T L; Miller S D; Bluestone J A
CTLA-4: a negative regulator of autoimmune disease.
The Journal of experimental medicine 1996;184(2):783-8.
1996: Walunas T L; Bakker C Y; Bluestone J A
CTLA-4 ligation blocks CD28-dependent T cell activation.
The Journal of experimental medicine 1996;183(6):2541-50.
1996: La Motte R N; Rubin M A; Barr E; Leiden J M; Bluestone J A; Mokyr M B
Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule.
Cancer immunology, immunotherapy : CII 1996;42(3):161-9.
1996: Woodle E S; Hussein S; Bluestone J A
In vivo administration of anti-murine CD3 monoclonal antibody induces selective, long-term anergy in CD8+ T cells.
Transplantation 1996;61(5):798-803.
1996: Bluestone J A
Costimulation and its role in organ transplantation.
Clinical transplantation 1996;10(1 Pt 2):104-9.
1996: Walunas T L; Sperling A I; Khattri R; Thompson C B; Bluestone J A
CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1006-13.
1996: Lenschow D J; Walunas T L; Bluestone J A
CD28/B7 system of T cell costimulation.
Annual review of immunology 1996;14():233-58.
1995: Miller S D; Vanderlugt C L; Lenschow D J; Pope J G; Karandikar N J; Dal Canto M C; Bluestone J A
Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE.
Immunity 1995;3(6):739-45.
1995: Lenschow D J; Zeng Y; Hathcock K S; Zuckerman L A; Freeman G; Thistlethwaite J R; Gray G S; Hodes R J; Bluestone J A
Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies.
Transplantation 1995;60(10):1171-8.
1995: Kaliyaperumal A; Falchetto R; Cox A; Dick R; Shabanowitz J; Chien Y H; Matis L; Hunt D F; Bluestone J A
Functional expression and recognition of nonclassical MHC class I T10b is not peptide-dependent.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(5):2379-86.
1995: Alegre M L; Tso J Y; Sattar H A; Smith J; Desalle F; Cole M; Bluestone J A
An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1544-55.
1995: Walunas T L; Bruce D S; Dustin L; Loh D Y; Bluestone J A
Ly-6C is a marker of memory CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(4):1873-83.
1995: Kearney E R; Walunas T L; Karr R W; Morton P A; Loh D Y; Bluestone J A; Jenkins M K
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(3):1032-6.
1995: Sperling A I; Green J M; Mosley R L; Smith P L; DiPaolo R J; Klein J R; Bluestone J A; Thompson C B
CD43 is a murine T cell costimulatory receptor that functions independently of CD28.
The Journal of experimental medicine 1995;182(1):139-46.
1995: Bluestone J A
New perspectives of CD28-B7-mediated T cell costimulation.
Immunity 1995;2(6):555-9.
1995: Green J M; Noel P J; Sperling A I; Walunas T L; Lenschow D J; Stack R; Gray G S; Bluestone J A; Thompson C B
T cell costimulation through the CD28 receptor.
Proceedings of the Association of American Physicians 1995;107(1):41-6.
1995: Lenschow D J; Ho S C; Sattar H; Rhee L; Gray G; Nabavi N; Herold K C; Bluestone J A
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.
The Journal of experimental medicine 1995;181(3):1145-55.
1995: Smith D M; Bluestone J A; Thistlethwaite J R; Woodle E S
Inhibition of T-cell activation by an anti-human class I MHC reactive monoclonal antibody occurs at a point distal to TCR-CD3 mediated signal transduction.
Transplantation proceedings 1995;27(1):395-7.
1995: DeLuca D; Bluestone J A; Shultz L D; Sharrow S O; Tatsumi Y
Programmed differentiation of murine thymocytes during fetal thymus organ culture.
Journal of immunological methods 1995;178(1):13-29.
1995: Alegre M L; Lenschow D J; Bluestone J A
Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.
Digestive diseases and sciences 1995;40(1):58-64.
1995: Bluestone J A; Khattri R; Sciammas R; Sperling A I
TCR gamma delta cells: a specialized T-cell subset in the immune system.
Annual review of cell and developmental biology 1995;11():307-53.
1994: Mokyr M B; Prokhorova A; Rubin M; Bluestone J A
Insight into the mechanism of TCR-V beta 8+/CD8+ T cell-mediated MOPC-315 tumor eradication.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(7):3123-34.
1994: Alegre M L; Peterson L J; Jeyarajah D R; Weiser M; Bluestone J A; Thistlethwaite J R
Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(6):2738-49.
1994: Zeng Y; Gage A; Montag A; Rothlein R; Thistlethwaite J R; Bluestone J A
Inhibition of transplant rejection by pretreatment of xenogeneic pancreatic islet cells with anti-ICAM-1 antibodies.
Transplantation 1994;58(6):681-9.
1994: Green J M; Noel P J; Sperling A I; Walunas T L; Gray G S; Bluestone J A; Thompson C B
Absence of B7-dependent responses in CD28-deficient mice.
Immunity 1994;1(6):501-8.
1994: Lenschow D J; Sperling A I; Cooke M P; Freeman G; Rhee L; Decker D C; Gray G; Nadler L M; Goodnow C C; Bluestone J A
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):1990-7.
1994: Smith D M; Bluestone J A; Jeyarajah D R; Newberg M H; Engelhard V H; Thistlethwaite J R; Woodle E S
Inhibition of T cell activation by a monoclonal antibody reactive against the alpha 3 domain of human MHC class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1054-67.
1994: Walunas T L; Lenschow D J; Bakker C Y; Linsley P S; Freeman G J; Green J M; Thompson C B; Bluestone J A
CTLA-4 can function as a negative regulator of T cell activation.
Immunity 1994;1(5):405-13.
1994: Sciammas R; Johnson R M; Sperling A I; Brady W; Linsley P S; Spear P G; Fitch F W; Bluestone J A
Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(11):5392-7.
1994: Alegre M L; Sattar H A; Herold K C; Smith J; Tepper M A; Bluestone J A
Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model.
Transplantation 1994;57(12):1786-94.
1994: Alegre M L; Peterson L J; Xu D; Sattar H A; Jeyarajah D R; Kowalkowski K; Thistlethwaite J R; Zivin R A; Jolliffe L; Bluestone J A
A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo.
Transplantation 1994;57(11):1537-43.
1994: Zeng Y; Torres M A; Thistlethwaite J R; Montag A; Bluestone J A
Prolongation of human pancreatic islet xenografts by pretreatment of islets with anti-human ICAM-1 monoclonal antibody.
Transplantation proceedings 1994;26(3):1120.
1994: Stack R M; Lenschow D J; Gray G S; Bluestone J A; Fitch F W
IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(12):5723-33.
1994: Rubin M; Bluestone J A; Newell K A; Prokhorova A; Mokyr M B
Cooperation between staphylococcal enterotoxin B and low dose melphalan in the cure of mice bearing a large MOPC-315 tumor and extensive metastases.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3522-9.
1994: Tatsumi Y; Deluca D; Cron R Q; Bluestone J A
Differential effects of T cell receptor ligation of TCR gamma delta thymocyte development in fetal thymic organ culture.
Thymus 1994;23(3-4):131-53.
1994: Sciammas R; Tatsumi Y; Sperling A I; Arunan K; Bluestone J A
TCR gamma delta cells: mysterious cells of the immune system.
Immunologic research 1994;13(4):268-79.
1993: Qian D; Sperling A I; Lancki D W; Tatsumi Y; Barrett T A; Bluestone J A; Fitch F W
The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(24):11875-9.
1993: Sperling A I; Linsley P S; Barrett T A; Bluestone J A
CD28-mediated costimulation is necessary for the activation of T cell receptor-gamma delta+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(11):6043-50.
1993: Lenschow D J; Su G H; Zuckerman L A; Nabavi N; Jellis C L; Gray G S; Miller J; Bluestone J A
Expression and functional significance of an additional ligand for CTLA-4.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11054-8.
1993: Mokyr M B; Rubin M; Newell K A; Prokhorova A; Bluestone J A
Involvement of TCR-V beta 8.3+ cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(9):4838-46.
1993: Bluestone J A; Kaliyaperumal A; Jameson S; Miller S; Dick R
Peptide-induced changes in class I heavy chains alter allorecognition.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(8):3943-53.
1993: Dent A L; Matis L A; Bluestone J A; Hedrick S M
Evidence for programmed cell death of self-reactive gamma delta T cell receptor-positive thymocytes.
European journal of immunology 1993;23(10):2482-7.
1993: Lenschow D J; Bluestone J A
T cell co-stimulation and in vivo tolerance.
Current opinion in immunology 1993;5(5):747-52.
1993: Tatsumi Y; Pena J C; Matis L; Deluca D; Bluestone J A
Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3030-41.
1993: Barrett T A; Tatsumi Y; Bluestone J A
Tolerance of T cell receptor gamma/delta cells in the intestine.
The Journal of experimental medicine 1993;177(6):1755-62.
1993: Bluestone J A; Bruce D; Peterson L; Thistlethwaite J R; Josephson M; Zeng Y; Linsley P S; Lenschow D J
Immunosuppressive effects of anti-CD3 MAb and soluble co-stimulatory molecules.
Transplantation proceedings 1993;25(1 Pt 1):546-7.
1993: Zeng Y; Bluestone J A; Ildstad S T; Torres M A; Montag A G; Thistlethwaite R J
Long-term functional xenograft tolerance after intrathymic islet transplantation (Lewis rat-->B6 mouse).
Transplantation proceedings 1993;25(1 Pt 1):438-9.
1992: Bluestone J A; Jameson S; Miller S; Dick R
Peptide-induced conformational changes in class I heavy chains alter major histocompatibility complex recognition.
The Journal of experimental medicine 1992;176(6):1757-61.
1992: Sperling A I; Cron R Q; Decker D C; Stern D A; Bluestone J A
Peripheral T cell receptor gamma delta variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3200-7.
1992: Barrett T A; Gajewski T F; Danielpour D; Chang E B; Beagley K W; Bluestone J A
Differential function of intestinal intraepithelial lymphocyte subsets.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1124-30.
1992: Lenschow D J; Zeng Y; Thistlethwaite J R; Montag A; Brady W; Gibson M G; Linsley P S; Bluestone J A
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg.
Science (New York, N.Y.) 1992;257(5071):789-92.
1992: Alegre M L; Collins A M; Pulito V L; Brosius R A; Olson W C; Zivin R A; Knowles R; Thistlethwaite J R; Jolliffe L K; Bluestone J A
Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3461-8.
1992: Woodle E S; Thistlethwaite J R; Jolliffe L K; Zivin R A; Collins A; Adair J R; Bodmer M; Athwal D; Alegre M L; Bluestone J A
Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2756-63.
1992: Bluestone J A; Spencer C; Hirsch R
The T cell receptor in autoimmune diseases.
The Journal of rheumatology. Supplement 1992;33():75-7.
1992: Herold K C; Bluestone J A; Montag A G; Parihar A; Wiegner A; Gress R E; Hirsch R
Prevention of autoimmune diabetes with nonactivating anti-CD3 monoclonal antibody.
Diabetes 1992;41(3):385-91.
1992: Johnson R M; Lancki D W; Sperling A I; Dick R F; Spear P G; Fitch F W; Bluestone J A
A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):983-8.
1992: Barrett T A; Delvy M L; Kennedy D M; Lefrancois L; Matis L A; Dent A L; Hedrick S M; Bluestone J A
Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue.
The Journal of experimental medicine 1992;175(1):65-70.
1991: Newell K A; Ellenhorn J D; Hirsch R; Bluestone J A
Immunopotentiation of anti-viral and anti-tumor immune responses using anti-T cell receptor antibodies and mitogens.
Annals of the New York Academy of Sciences 1991;636():279-87.
1991: Woodle E S; Thistlethwaite J R; Ghobrial I A; Jolliffe L K; Stuart F P; Bluestone J A
OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release.
Transplantation 1991;52(2):354-60.
1991: Woodle E S; Thistlethwaite J R; Jolliffe L K; Fucello A J; Stuart F P; Bluestone J A
Anti-CD3 monoclonal antibody therapy. An approach toward optimization by in vitro analysis of new anti-CD3 antibodies.
Transplantation 1991;52(2):361-8.
1991: Bluestone J A; Cron R Q; Barrett T A; Houlden B; Sperling A I; Dent A; Hedrick S; Rellahan B; Matis L A
Repertoire development and ligand specificity of murine TCR gamma delta cells.
Immunological reviews 1991;120():5-33.
1991: Newell K A; Ellenhorn J D; Bruce D S; Bluestone J A
In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):1074-8.
1991: Woodle E S; Thistlethwaite J R; Jolliffe L K; Ghobrial I; Fuccello A J; Stuart F P; Bluestone J A
T-cell activation and lymphokine production induced by antihuman CD3 monoclonal antibodies.
Transplantation proceedings 1991;23(1 Pt 1):81-2.
1991: Rellahan B L; Bluestone J A; Houlden B A; Cotterman M M; Matis L A
Junctional sequences influence the specificity of gamma/delta T cell receptors.
The Journal of experimental medicine 1991;173(2):503-6.
1991: Houlden B A; Widacki S M; Bluestone J A
Signal transduction through class I MHC by a monoclonal antibody that detects multiple murine and human class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(2):425-30.
1991: Barrett T A; Hedrick S M; Dent A L; Delvy M L; Kennedy D M; Matis L A; Bluestone J A
Control of self-reactivity in the intestine.
Immunologic research 1991;10(3-4):341-8.
1991: Bluestone J A; Cron R Q; Rellahan B; Matis L A
Ligand specificity and repertoire development of murine TCR gamma delta cells.
Current topics in microbiology and immunology 1991;173():133-9.
1990: Ellenhorn J D; Woodle E S; Thistlethwaite J R; Bluestone J A
T lymphocyte activation following OKT3 treatment.
Current surgery 1990;47(6):458-9.
1990: Ellenhorn J D; Woodle E S; Ghobreal I; Thistlethwaite J R; Bluestone J A
Activation of human T cells in vivo following treatment of transplant recipients with OKT3.
Transplantation 1990;50(4):608-12.
1990: Ezquerra A; Cron R Q; McConnell T J; Valas R B; Bluestone J A; Coligan J E
T cell receptor delta-gene expression and diversity in the mouse spleen.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(5):1311-7.
1990: Bluestone J A; Matis L A
Are TCR alpha beta cells and TCR gamma delta cells that different?
Research in immunology 1990;141(7):606-10.
1990: Ellenhorn J D; Schreiber H; Bluestone J A
Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(7):2840-6.
1990: Dent A L; Matis L A; Hooshmand F; Widacki S M; Bluestone J A; Hedrick S M
Self-reactive gamma delta T cells are eliminated in the thymus.
Nature 1990;343(6260):714-9.
1990: Cron R Q; Coligan J E; Bluestone J A
Polymorphisms and diversity of T-cell receptor-gamma proteins expressed in mouse spleen.
Immunogenetics 1990;31(4):220-8.
1989: Cron R Q; Ezquerra A; Coligan J E; Houlden B A; Bluestone J A; Maloy W L
Identification of distinct T cell receptor (TCR)-gamma delta heterodimers using an anti-TCR-gamma variable region serum.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3769-75.
1989: Matis L A; Fry A M; Cron R Q; Cotterman M M; Dick R F; Bluestone J A
Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer.
Science (New York, N.Y.) 1989;245(4919):746-9.
1989: Cron R Q; Gajewski T F; Sharrow S O; Fitch F W; Matis L A; Bluestone J A
Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(11):3754-62.
1989: Bluestone J A; Matis L A
TCR gamma delta cells--minor redundant T cell subset or specialized immune system component?
Journal of immunology (Baltimore, Md. : 1950) 1989;142(6):1785-8.
1989: Ellenhorn J D; Hirsch R; Hartley J P; Bluestone J A
Dose-dependent activation of murine T cells following in vivo administration of anti-murine CD3.
Transplantation proceedings 1989;21(1 Pt 1):1013-4.
1989: Houlden B A; Matis L A; Cron R Q; Widacki S M; Brown G D; Pampeno C; Meruelo D; Bluestone J A
A TCR gamma delta cell recognizing a novel TL-encoded gene product.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():45-55.
1989: Evavold B D; Yokoyama A; Hirsch R; Bluestone J A; Quintans J
T helper 2 (Th2) but not Th1 clones co-stimulate resting T cells in the presence of anti-CD3 monoclonal antibody.
International immunology 1989;1(4):443-9.
1988: Houlden B A; Cron R Q; Coligan J E; Bluestone J A
Systematic development of distinct T cell receptor-gamma delta T cell subsets during fetal ontogeny.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(11):3753-9.
1988: Bluestone J A; Cron R Q; Cotterman M; Houlden B A; Matis L A
Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.
The Journal of experimental medicine 1988;168(5):1899-916.
1988: Ellenhorn J D; Hirsch R; Schreiber H; Bluestone J A
In vivo administration of anti-CD3 prevents malignant progressor tumor growth.
Science (New York, N.Y.) 1988;242(4878):569-71.
1987: Matis L A; Cron R; Bluestone J A
Major histocompatibility complex-linked specificity of gamma delta receptor-bearing T lymphocytes.
Nature 1987;330(6145):262-4.

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