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Tokuyuki Shinohara

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Yasuhiro Kazuki; Hidetoshi Hoshiya; Yoshiteru Kai; Satoshi Abe; M Takiguchi; M Osaki; S Kawazoe; Motonobu Katoh; Mito Kanatsu-Shinohara; K Inoue; N Kajitani; T Yoshino; Yasuaki Shirayoshi; Atsuo Ogura; Tokuyuki Shinohara; J Carl Barrett; Mitsuo Oshimura
Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome.
Yasuhiro Kazuki; Thomas C Schulz; Tokuyuki Shinohara; Mitsutaka Kadota; Ryuichi Nishigaki; Toshiaki Inoue; M Kimura; Yoshiteru Kai; Satoshi Abe; Yasuaki Shirayoshi; Mitsuo Oshimura
A new mouse model for Down syndrome.
Ryuichi Nishigaki; Tokuyuki Shinohara; Tosifusa Toda; Akira Omori; Sachiyo Ichinose; Masayuki Itoh; Yasuaki Shirayoshi; Akihiro Kurimasa; Mitsuo Oshimura
An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome.

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2008: Yasuhiro Kazuki; Hidetoshi Hoshiya; Yoshiteru Kai; Satoshi Abe; M Takiguchi; M Osaki; S Kawazoe; Motonobu Katoh; Mito Kanatsu-Shinohara; K Inoue; N Kajitani; T Yoshino; Yasuaki Shirayoshi; Atsuo Ogura; Tokuyuki Shinohara; J Carl Barrett; Mitsuo Oshimura
Correction of a genetic defect in multipotent germline stem cells using a human artificial chromosome.
Gene therapy 2008;15(8):617-24.
2003: Yasuhiro Kazuki; Thomas C Schulz; Tokuyuki Shinohara; Mitsutaka Kadota; Ryuichi Nishigaki; Toshiaki Inoue; M Kimura; Yoshiteru Kai; Satoshi Abe; Yasuaki Shirayoshi; Mitsuo Oshimura
A new mouse model for Down syndrome.
Journal of neural transmission. Supplementum 2003;(67):1-20.
2002: Ryuichi Nishigaki; Tokuyuki Shinohara; Tosifusa Toda; Akira Omori; Sachiyo Ichinose; Masayuki Itoh; Yasuaki Shirayoshi; Akihiro Kurimasa; Mitsuo Oshimura
An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome.
Biochemical and biophysical research communications 2002;295(1):112-8.
2002: Yoshimi Kuroiwa; Hitoshi Yoshida; T Ohshima; Tokuyuki Shinohara; Atsuko Ohguma; Yasuhiro Kazuki; Mitsuo Oshimura; Isao Ishida; Kazuma Tomizuka
The use of chromosome-based vectors for animal transgenesis.
Gene therapy 2002;9(11):708-12.
2001: Tokuyuki Shinohara; Kazuma Tomizuka; S Miyabara; S Takehara; Yasuhiro Kazuki; J Inoue; Motonobu Katoh; H Nakane; Akihiro Iino; Atsuko Ohguma; S Ikegami; K Inokuchi; Isao Ishida; Roger H Reeves; Mitsuo Oshimura
Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.
Human molecular genetics 2001;10(11):1163-75.
2001: Yasuhiro Kazuki; Tokuyuki Shinohara; Kazuma Tomizuka; Motonobu Katoh; Atsuko Ohguma; Isao Ishida; Mitsuo Oshimura
Germline transmission of a transferred human chromosome 21 fragment in transchromosomal mice.
Journal of human genetics 2001;46(10):600-3.
2001: J Inoue; Kohzoh Mitsuya; Shinji Maegawa; Hiroyuki Kugoh; Mitsutaka Kadota; D Okamura; Tokuyuki Shinohara; S Nishihara; S Takehara; K Yamauchi; Thomas C Schulz; Mitsuo Oshimura
Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6.
Journal of human genetics 2001;46(3):137-45.
2000: Yoshimi Kuroiwa; Kazuma Tomizuka; Tokuyuki Shinohara; Yasuhiro Kazuki; Hitoshi Yoshida; Atsuko Ohguma; T Yamamoto; S Tanaka; Mitsuo Oshimura; Isao Ishida
Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts.
Nature biotechnology 2000;18(10):1086-90.
2000: Toshiaki Inoue; Tokuyuki Shinohara; S Takehara; J Inoue; H Kamino; Hiroyuki Kugoh; Mitsuo Oshimura
Specific impairment of cardiogenesis in mouse ES cells containing a human chromosome 21.
Biochemical and biophysical research communications 2000;273(1):219-24.
2000: Kazuma Tomizuka; Tokuyuki Shinohara; Hitoshi Yoshida; H Uejima; Atsuko Ohguma; S Tanaka; K Sato; Mitsuo Oshimura; Isao Ishida
Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):722-7.
2000: Tokuyuki Shinohara; Kazuma Tomizuka; S Takehara; K Yamauchi; Motonobu Katoh; Atsuko Ohguma; Isao Ishida; Mitsuo Oshimura
Stability of transferred human chromosome fragments in cultured cells and in mice.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2000;8(8):713-25.
1998: H Uejima; Tokuyuki Shinohara; Y Nakayama; Hiroyuki Kugoh; Mitsuo Oshimura
Mapping a novel cellular-senescence gene to human chromosome 2q37 by irradiation microcell-mediated chromosome transfer.
Molecular carcinogenesis 1998;22(1):34-45.