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Norihito Shintani

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Chemicals & Drugs

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Publications

TOP 3
Hiroaki Inoue; Yusuke Sakurai; Norihito Shintani; Akemichi Baba; Atsuko Hayata-Takano; Shintaro Higashi; Hitoshi Hashimoto
PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density.
Minako Tajiri; Akemichi Baba; Atsuko Hayata-Takano; Keisuke Hazama; Katsuya Ogata; Kaoru Seiriki; Norihito Shintani; Hitoshi Hashimoto
Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders.
Yusuke Sakurai; Norihito Shintani; Atsuko Hayata-Takano; Hiroaki Inoue; Akihiro Arimori; Akemichi Baba; Ken-ichi Hamagami; Hitoshi Hashimoto
Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells.

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All Publications

2013: Hiroaki Inoue; Yusuke Sakurai; Norihito Shintani; Akemichi Baba; Atsuko Hayata-Takano; Shintaro Higashi; Hitoshi Hashimoto
PACAP Inhibits β-cell Mass Expansion in a Mouse Model of Type II Diabetes: Persistent Suppressive Effects on Islet Density.
Frontiers in endocrinology 2013;4():27.
2012: Minako Tajiri; Akemichi Baba; Atsuko Hayata-Takano; Keisuke Hazama; Katsuya Ogata; Kaoru Seiriki; Norihito Shintani; Hitoshi Hashimoto
Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders.
Journal of molecular neuroscience : MN 2012;48(3):473-81.
2012: Yusuke Sakurai; Norihito Shintani; Atsuko Hayata-Takano; Hiroaki Inoue; Akihiro Arimori; Akemichi Baba; Ken-ichi Hamagami; Hitoshi Hashimoto
Compensatory recovery of blood glucose levels in KKA(y) mice fed a high-fat diet: insulin-sparing effects of PACAP overexpression in β cells.
Journal of molecular neuroscience : MN 2012;48(3):647-53.
2012: Takeshi Shimada; Kikuko Shinohara; Norihito Shintani; Yoshihiro Takai; Akihiro Toi; Keiko Tominaga-Yoshino; Atsushi Yamasaki; Kouji Asano; Akemichi Baba; Atsuko Hayata-Takano; Akihiko Ogura; Hitoshi Hashimoto
A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells.
Journal of neurochemistry 2012;122(1):81-93.
2012: Ryota Haba; Akemichi Baba; Atsuko Hayata; Yusuke Onaka; Norihito Shintani; Risa Takenaga; Hyper Wang; Hitoshi Hashimoto
Lipopolysaccharide affects exploratory behaviors toward novel objects by impairing cognition and/or motivation in mice: Possible role of activation of the central amygdala.
Behavioural brain research 2012;228(2):423-31.
2011: Naohiro Tsukiyama; Hitoshi Hashimoto; Atsuko Hayata; Keisuke Hazama; Michiya Kakuda; Yoshiko Morita; Katsuya Ogata; Yoko Saida; Norihito Shintani; Minako Tajiri; Mamoru Tanida; Akemichi Baba
PACAP centrally mediates emotional stress-induced corticosterone responses in mice.
Stress (Amsterdam, Netherlands) 2011;14(4):368-75.
2011: Yukio Ago; M Yoneyama; T Ishihama; S Kataoka; K Kawada; Toshiyuki Tanaka; K Ogita; Norihito Shintani; Hisashi Hashimoto; Akemichi Baba; Kazuhiro Takuma; Toshio Matsuda
Role of endogenous pituitary adenylate cyclase-activating polypeptide in adult hippocampal neurogenesis.
Neuroscience 2011;172():554-61.
2011: Hitoshi Hashimoto; Norihito Shintani; Mamoru Tanida; Atsuko Hayata; Ryota Hashimoto; Akemichi Baba
PACAP is implicated in the stress axes.
Current pharmaceutical design 2011;17(10):985-9.
2011: Yusuke Sakurai; Norihito Shintani; Atsuko Hayata; Hitoshi Hashimoto; Akemichi Baba
Trophic effects of PACAP on pancreatic islets: a mini-review.
Journal of molecular neuroscience : MN 2011;43(1):3-7.
2011: Yusuke Sakurai; Norihito Shintani; Akihiro Arimori; Ken-Ichi Hamagami; Naoko Higuchi; Hiroaki Inoue; Kazuya Ikeda; Atsuko Hayata; Hitoshi Hashimoto; Akemichi Baba
Cerulein-induced acute pancreatitis in PACAP knockout mice.
Journal of molecular neuroscience : MN 2011;43(1):8-15.
2010: Toshihiro Ishihama; Yukio Ago; Norihito Shintani; Hitoshi Hashimoto; Akemichi Baba; Kazuhiro Takuma; Toshio Matsuda
Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice.
Behavioural brain research 2010;209(2):274-80.
2010: Ryota Hashimoto; Hitoshi Hashimoto; Norihito Shintani; Kazutaka Ohi; Hiroaki Hori; Osamu Saitoh; Asako Kosuga; Masahiko Tatsumi; Nakao Iwata; Norio Ozaki; Kunitoshi Kamijima; Akemichi Baba; Masatoshi Takeda; Hiroshi Kunugi
Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder.
Neuroscience letters 2010;468(3):300-2.
2010: Michiyoshi Hatanaka; Norihiro Shibata; Norihito Shintani; Ryota Haba; Atsuko Hayata; Hitoshi Hashimoto; Akemichi Baba
15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells.
Journal of pharmacological sciences 2010;113(1):89-93.
2010: Chihiro Kawaguchi; Yasushi Isojima; Norihito Shintani; Michiyoshi Hatanaka; Xiaohong Guo; Nobuaki Okumura; Katsuya Nagai; Hitoshi Hashimoto; Akemichi Baba
PACAP-deficient mice exhibit light parameter-dependent abnormalities on nonvisual photoreception and early activity onset.
PloS one 2010;5(2):e9286.
2010: Kohei Yamada; Shinsuke Matsuzaki; Tsuyoshi Hattori; Ryusuke Kuwahara; Manabu Taniguchi; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba; Natsuko Kumamoto; Kazuo Yamada; Takeo Yoshikawa; Taiichi Katayama; Masaya Tohyama
Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations.
PloS one 2010;5(1):e8596.
2010: Kazuhiro Tanaka; Akiko Kunishige-Yamamoto; Hitoshi Hashimoto; Norihito Shintani; Atsuko Hayata; Akemichi Baba
Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice.
Biochemical and biophysical research communications 2010;391(1):773-7.
2009: Ken-ichi Hamagami; Yusuke Sakurai; Norihito Shintani; Naoko Higuchi; Kazuya Ikeda; Hitoshi Hashimoto; Akinobu Suzuki; Hiroshi Kiyama; Akemichi Baba
Over-expression of pancreatic pituitary adenylate cyclase-activating polypeptide (PACAP) aggravates cerulein-induced acute pancreatitis in mice.
Journal of pharmacological sciences 2009;110(4):451-8.
2009: Hitoshi Hashimoto; Ryota Hashimoto; Norihito Shintani; Kazuhiro Tanaka; Akiko Yamamoto; Michiyoshi Hatanaka; Xiaohong Guo; Yoshiko Morita; Mamoru Tanida; Katsuya Nagai; Masatoshi Takeda; Akemichi Baba
Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone.
Journal of neurochemistry 2009;110(2):595-602.
2009: Rie Tsuchida; Masahiro Kubo; Norihito Shintani; Michikazu Abe; Katalin Köves; Kazuki Uetsuki; Mariko Kuroda; Hitoshi Hashimoto; Akemichi Baba
Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons.
Biological & pharmaceutical bulletin 2009;32(4):728-31.
2009: Rie Tsuchida; Masahiro Kubo; Mariko Kuroda; Yasuhiro Shibasaki; Norihito Shintani; Michikazu Abe; Katalin Köves; Hitoshi Hashimoto; Akemichi Baba
An antihyperkinetic action by the serotonin 1A-receptor agonist osemozotan co-administered with psychostimulants or the non-stimulant atomoxetine in mice.
Journal of pharmacological sciences 2009;109(3):396-402.
2008: Michiyoshi Hatanaka; Mamoru Tanida; Norihito Shintani; Yasushi Isojima; Chihiro Kawaguchi; Hitoshi Hashimoto; Michiya Kakuda; Ryota Haba; Katsuya Nagai; Akemichi Baba
Lack of light-induced elevation of renal sympathetic nerve activity and plasma corticosterone levels in PACAP-deficient mice.
Neuroscience letters 2008;444(2):153-6.
2008: Shuhei Tomimoto; Tatsuya Ojika; Norihito Shintani; Hitoshi Hashimoto; Ken-Ichi Hamagami; Kazuya Ikeda; Masanori Nakata; Toshihiko Yada; Yusuke Sakurai; Takeshi Shimada; Yoshiko Morita; Chie Ishida; Akemichi Baba
Markedly reduced white adipose tissue and increased insulin sensitivity in adcyap1-deficient mice.
Journal of pharmacological sciences 2008;107(1):41-8.
2007: Ryota Hashimoto; Hitoshi Hashimoto; Norihito Shintani; Sachie Chiba; S Hattori; Takeya Okada; M Nakajima; Kazuhiro Tanaka; Naofumi Kawagishi; Kiyotaka Nemoto; Takeyuki Mori; Takashi Ohnishi; Hiroko Noguchi; Hiroaki Hori; Tatsuyo Suzuki; Nakao Iwata; Norio Ozaki; T Nakabayashi; O Saitoh; Asako Kosuga; Masahiko Tatsumi; Kunitoshi Kamijima; Daniel R Weinberger; Hiroshi Kunugi; Akemichi Baba
Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia.
Molecular psychiatry 2007;12(11):1026-32.
2007: Harumi Fujii; Toshihiro Ishihama; Yukio Ago; Norihito Shintani; Michiya Kakuda; Hitoshi Hashimoto; Akemichi Baba; Toshio Matsuda
Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice.
Peptides 2007;28(9):1674-9.
2007: Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba
[Neuropeptide PACAP and neuropsychological function: unexpected insights from mouse mutants].
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(4):375-9.
2007: T Hattori; Kousuke Baba; S Matsuzaki; Akiko Honda; K Miyoshi; K Inoue; Manabu Taniguchi; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba; S Shimizu; F Yukioka; N Kumamoto; A Yamaguchi; Masaya Tohyama; Taiichi Katayama
A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth.
Molecular psychiatry 2007;12(4):398-407.
2007: Norihito Shintani; Kiyokazu Ogita; Hitoshi Hashimoto; Akemichi Baba
Recent studies on the trimethyltin actions in central nervous systems.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(3):451-61.
2006: Yutaka Koyama; Masafumi Kiyo-oka; Masakazu Osakada; Naotaka Horiguchi; Norihito Shintani; Yukio Ago; Michiya Kakuda; Akemichi Baba; Toshio Matsuda
Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation.
Brain research 2006;1112(1):65-9.
2006: Norihito Shintani; Hitoshi Hashimoto; Kazuhiro Tanaka; Naofumi Kawagishi; Chihiro Kawaguchi; Michiyoshi Hatanaka; Yukio Ago; Toshio Matsuda; Akemichi Baba
Serotonergic inhibition of intense jumping behavior in mice lacking PACAP (Adcyap1-/-).
Annals of the New York Academy of Sciences 2006;1070():545-9.
2006: Yoshiko Morita; Daisuke Yanagida; Norihito Shintani; Kiyokazu Ogita; Norito Nishiyama; Rie Tsuchida; Hitoshi Hashimoto; Akemichi Baba
Lack of trimethyltin (TMT)-induced elevation of plasma corticosterone in PACAP-deficient mice.
Annals of the New York Academy of Sciences 2006;1070():450-6.
2006: Megumi Hirose; Hitoshi Hashimoto; Junko Iga; Norihito Shintani; Megumi Nakanishi; Naohisa Arakawa; Takeshi Shimada; Akemichi Baba
Inhibition of self-renewal and induction of neural differentiation by PACAP in neural progenitor cells.
Annals of the New York Academy of Sciences 2006;1070():342-7.
2006: Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba
New insights into the central PACAPergic system from the phenotypes in PACAP- and PACAP receptor-knockout mice.
Annals of the New York Academy of Sciences 2006;1070():75-89.
2006: Kazuhiro Tanaka; Norihito Shintani; Hitoshi Hashimoto; Naofumi Kawagishi; Yukio Ago; Toshio Matsuda; Ryota Hashimoto; Hiroshi Kunugi; Akiko Yamamoto; Chihiro Kawaguchi; Takeshi Shimada; Akemichi Baba
Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(19):5091-7.
2005: Norihito Shintani; Sayoko Suetake; Hitoshi Hashimoto; Kazumi Koga; Atsushi Kasai; Chihiro Kawaguchi; Yoshiko Morita; Megumi Hirose; Yoshiyuki Sakai; Shuhei Tomimoto; Toshio Matsuda; Akemichi Baba
Neuroprotective action of endogenous PACAP in cultured rat cortical neurons.
Regulatory peptides 2005;126(1-2):123-8.
2005: Megumi Hirose; Hitoshi Hashimoto; Norihito Shintani; Megumi Nakanishi; Naohisa Arakawa; Junko Iga; Hitoshi Niwa; Jun-Ichi Miyazaki; Akemichi Baba
Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells.
Regulatory peptides 2005;126(1-2):109-13.
2004: Norihito Shintani; Hitoshi Hashimoto; Kazuhiro Tanaka; Chihiro Kawaguchi; Shuhei Tomimoto; Akemichi Baba
Overexpression of PACAP in the pancreas failed to rescue early postnatal mortality in PACAP-null mice.
Regulatory peptides 2004;123(1-3):155-9.
2004: Kazuhiro Tanaka; Hitoshi Hashimoto; Norihito Shintani; Akiko Yamamoto; Akemichi Baba
Reduced hypothermic and hypnotic responses to ethanol in PACAP-deficient mice.
Regulatory peptides 2004;123(1-3):95-8.
2004: Atsushi Kasai; Norihito Shintani; Maki Oda; Michiya Kakuda; Hitoshi Hashimoto; Toshio Matsuda; Shuji Hinuma; Akemichi Baba
Apelin is a novel angiogenic factor in retinal endothelial cells.
Biochemical and biophysical research communications 2004;325(2):395-400.
2004: Norihito Shintani
[Mice lacking PACAP: a mini-review focussing on brain function].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2004;124(10):667-71.
2004: Shuhei Tomimoto; Hitoshi Hashimoto; Norihito Shintani; Kyohei Yamamoto; Yuki Kawabata; Ken-Ichi Hamagami; Kazuya Yamagata; Jun-ichiro Miyagawa; Akemichi Baba
Overexpression of pituitary adenylate cyclase-activating polypeptide in islets inhibits hyperinsulinemia and islet hyperplasia in agouti yellow mice.
The Journal of pharmacology and experimental therapeutics 2004;309(2):796-803.
2004: Yoshiyuki Sakai; Hitoshi Hashimoto; Norihito Shintani; Hironori Katoh; Manabu Negishi; Chihiro Kawaguchi; Atsushi Kasai; Akemichi Baba
PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells.
Brain research. Molecular brain research 2004;123(1-2):18-26.
2004: Norihito Shintani; Hitoshi Hashimoto; Akemichi Baba
[Altered higher brain function in PACAP-knockout mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2004;123(4):274-80.
2004: Shuhei Tomimoto; Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba
[Transgenic mice overexpressing PACAP in pancreatic beta-cells: acute and chronic effects on insulin and glucose homeostasis].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2004;123(4):261-6.
2003: Norihito Shintani; Shuhei Tomimoto; Hitoshi Hashimoto; Chihiro Kawaguchi; Akemichi Baba
Functional roles of the neuropeptide PACAP in brain and pancreas.
Life sciences 2003;74(2-3):337-43.
2003: Hitoshi Hashimoto; Akiyoshi Kunugi; Naohisa Arakawa; Norihito Shintani; Takashi Fujita; Atsushi Kasai; Chihiro Kawaguchi; Yoshiko Morita; Megumi Hirose; Yoshiyuki Sakai; Akemichi Baba
Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes.
Biochemical and biophysical research communications 2003;311(2):337-43.
2003: Norihito Shintani; Kazuhiro Tanaka; Hitoshi Hashimoto; Akemichi Baba
[Altered behavioral response to centrally acting drugs in mice lacking PACAP].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122 Suppl():1P-4P.
2003: Hitoshi Hashimoto; Norihito Shintani
[In vivo functional analysis of the neuropeptide PACAP using gene-targeted mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(5):427-35.
2003: Chihiro Kawaguchi; Kazuhiro Tanaka; Yasushi Isojima; Norihito Shintani; Hitoshi Hashimoto; Akemichi Baba; Katsuya Nagai
Changes in light-induced phase shift of circadian rhythm in mice lacking PACAP.
Biochemical and biophysical research communications 2003;310(1):169-75.
2003: Kyohei Yamamoto; Hitoshi Hashimoto; Shuhei Tomimoto; Norihito Shintani; Jun-ichi Miyazaki; Fumi Tashiro; Hiroyuki Aihara; Takao Nammo; Ming Li; Kazuya Yamagata; Jun-ichiro Miyagawa; Yuji Matsuzawa; Yuki Kawabata; Yuji Fukuyama; Kazumi Koga; Wakaba Mori; Kazuhiro Tanaka; Toshio Matsuda; Akemichi Baba
Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.
Diabetes 2003;52(5):1155-62.
2002: Yoshiyuki Sakai; Hitoshi Hashimoto; Norihito Shintani; Ayako Ichibori; Shuhei Tomimoto; Kazuhiro Tanaka; Megumi Hirose; Akemichi Baba
Involvement of intracellular Ca2+ elevation but not cyclic AMP in PACAP-induced p38 MAP kinase activation in PC12 cells.
Regulatory peptides 2002;109(1-3):149-53.
2002: Norihito Shintani; Wakaba Mori; Hitoshi Hashimoto; Masayuki Imai; Kazuhiro Tanaka; Shuhei Tomimoto; Megumi Hirose; Chihiro Kawaguchi; Akemichi Baba
Defects in reproductive functions in PACAP-deficient female mice.
Regulatory peptides 2002;109(1-3):45-8.
2002: Hitoshi Hashimoto; Norihito Shintani; Akemichi Baba
Higher brain functions of PACAP and a homologous Drosophila memory gene amnesiac: insights from knockouts and mutants.
Biochemical and biophysical research communications 2002;297(3):427-31.
2001: Hisashi Hashimoto; Norihito Shintani; Keiichi Tanaka; Wakaba Mori; Megumi Hirose; Toshio Matsuda; M Sakaue; Jun-ichi Miyazaki; Hitoshi Niwa; Fumi Tashiro; Koji Yamamoto; Kazumi Koga; Shuhei Tomimoto; Akiyoshi Kunugi; S Suetake; Akemichi Baba
Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(23):13355-60.
2001: Yoshiyuki Sakai; Hisashi Hashimoto; Norihito Shintani; Shuhei Tomimoto; Keiichi Tanaka; Ayako Ichibori; Megumi Hirose; Akemichi Baba
Involvement of p38 MAP kinase pathway in the synergistic activation of PACAP mRNA expression by NGF and PACAP in PC12h cells.
Biochemical and biophysical research communications 2001;285(3):656-61.
2000: Norihito Shintani; Hisashi Hashimoto; Akiyoshi Kunugi; Yutaka Koyama; Koji Yamamoto; Shuhei Tomimoto; Wakaba Mori; Toshio Matsuda; Akemichi Baba
Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type I PACAP (PAC(1)) receptor.
Biochimica et biophysica acta 2000;1509(1-2):195-202.
2000: Hisashi Hashimoto; Norihito Shintani; A Nishino; M Okabe; M Ikawa; S Matsuyama; K Itoh; Koji Yamamoto; Shuhei Tomimoto; Takashi Fujita; N Hagihara; Wakaba Mori; Yutaka Koyama; Toshio Matsuda; S Nagata; Akemichi Baba
Mice with markedly reduced PACAP (PAC(1)) receptor expression by targeted deletion of the signal peptide.
Journal of neurochemistry 2000;75(5):1810-7.
2000: Hisashi Hashimoto; N Hagihara; Kazumi Koga; Koji Yamamoto; Norihito Shintani; Shuhei Tomimoto; Wakaba Mori; Yutaka Koyama; Toshio Matsuda; Akemichi Baba
Synergistic induction of pituitary adenylate cyclase-activating polypeptide (PACAP) gene expression by nerve growth factor and PACAP in PC12 cells.
Journal of neurochemistry 2000;74(2):501-7.
1999: Hisashi Hashimoto; A Nishino; Norihito Shintani; N Hagihara; Neal G Copeland; NA Jenkins; Koji Yamamoto; Toshio Matsuda; T Ishihara; S Nagata; Akemichi Baba
Genomic organization and chromosomal location of the mouse vasoactive intestinal polypeptide 1 (VPAC1) receptor.
Genomics 1999;58(1):90-3.