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Kristie Blum

Research Profile

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Emilia Mahoney; Lisa L Smith; Amy J Wagner; Yuh-Ying Yeh; Xiaoli Zhang; Leslie Andritsos; Kristie A Blum; Joseph M Flynn; Michael R Grever; Sneha V Gupta; Metin Gurcan; Sarah Elizabeth May Herman; Amy J Johnson; Jeffrey A Jones; Hui Kong; Amy Lehman; David M Lucas; John C Byrd
ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
Jonathon B Cohen; Kristie A Blum
Evaluation and management of lymphoma and leukemia in pregnancy.
Sarah Elizabeth May Herman; Erin Hertlein; Samantha Jaglowski; Amy J Johnson; Jeffrey Jones; Asha Ramanunni; Xiaoli Zhang; Kristie A Blum; Joseph J Buggy; Joseph Flynn; Amber L Gordon; Ahmed Hamdy; John C Byrd
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

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All Publications

2012: Emilia Mahoney; Lisa L Smith; Amy J Wagner; Yuh-Ying Yeh; Xiaoli Zhang; Leslie Andritsos; Kristie A Blum; Joseph M Flynn; Michael R Grever; Sneha V Gupta; Metin Gurcan; Sarah Elizabeth May Herman; Amy J Johnson; Jeffrey A Jones; Hui Kong; Amy Lehman; David M Lucas; John C Byrd
ER stress and autophagy: new discoveries in the mechanism of action and drug resistance of the cyclin-dependent kinase inhibitor flavopiridol.
Blood 2012;120(6):1262-73.
2011: Jonathon B Cohen; Kristie A Blum
Evaluation and management of lymphoma and leukemia in pregnancy.
Clinical obstetrics and gynecology 2011;54(4):556-66.
2011: Sarah Elizabeth May Herman; Erin Hertlein; Samantha Jaglowski; Amy J Johnson; Jeffrey Jones; Asha Ramanunni; Xiaoli Zhang; Kristie A Blum; Joseph J Buggy; Joseph Flynn; Amber L Gordon; Ahmed Hamdy; John C Byrd
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.
Blood 2011;117(23):6287-96.
2011: Sarah Elizabeth May Herman; Rosa Lapalombella; Amber L Gordon; Asha Ramanunni; Kristie A Blum; Jeffrey Jones; Xiaoli Zhang; Brian J Lannutti; Kamal D Puri; Natarajan Muthusamy; John C Byrd; Amy J Johnson
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.
Blood 2011;117(16):4323-7.
2010: Kristie A Blum; Zhongfa Liu; David M Lucas; Ping Chen; Zhiliang Xie; Robert Baiocchi; Donald M Benson; Steven M Devine; Jeffrey Jones; Leslie Andritsos; Joseph Flynn; Christoph Plass; Guido Marcucci; Kenneth K Chan; Michael R Grever; John C Byrd
Phase I trial of low dose decitabine targeting DNA hypermethylation in patients with chronic lymphocytic leukaemia and non-Hodgkin lymphoma: dose-limiting myelosuppression without evidence of DNA hypomethylation.
British journal of haematology 2010;150(2):189-95.
2010: Rosa Lapalombella; Leslie Andritsos; Qing Liu; Sarah Elizabeth May Herman; Rebekah Browning; Lan V Pham; Kristie A Blum; William Blum; Asha Ramanunni; Chelsey A Raymond; Lisa L Smith; Amy Lehman; Xiaokui Mo; David Jarjoura; Ching-Shih Chen; Richard Ford; Christoph Rader; Natarajan Muthusamy; Amy J Johnson; John C Byrd
Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway.
Blood 2010;115(13):2619-29.
2010: Jennifer A Woyach; Nyla A Heerema; John Zhao; Andrew McFaddin; Amy Stark; Thomas S Lin; Leslie A Andritsos; Kristie A Blum; Joseph M Flynn; Jeffrey A Jones; John C Byrd
Dic(17;18)(p11.2;p11.2) is a recurring abnormality in chronic lymphocytic leukaemia associated with aggressive disease.
British journal of haematology 2010;148(5):754-9.
2010: Thomas S Lin; Kristie A Blum; Diane Beth Fischer; Sarah M Mitchell; Amy S Ruppert; Pierluigi Porcu; Eric H Kraut; Robert A Baiocchi; Mollie E Moran; Amy J Johnson; Larry J Schaaf; Michael R Grever; John C Byrd
Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(3):418-23.
2010: Kristie A Blum
Upcoming diagnostic and therapeutic developments in classical Hodgkin's lymphoma.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2010;2010():93-100.
2010: David M Lucas; Lapo Alinari; Derek A West; Melanie E Davis; Ryan B Edwards; Amy J Johnson; Kristie A Blum; Craig C Hofmeister; Michael A Freitas; Mark R Parthun; Dasheng Wang; Amy Lehman; Xiaoli Zhang; David Jarjoura; Samuel K Kulp; Carlo M Croce; Michael R Grever; Ching-Shih Chen; Robert A Baiocchi; John C Byrd
The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.
PloS one 2010;5(6):e10941.
2009: Thomas S Lin; Amy S Ruppert; Amy J Johnson; Beth Fischer; Nyla A Heerema; Leslie A Andritsos; Kristie A Blum; Joseph M Flynn; Jeffrey A Jones; Weihong Hu; Mollie E Moran; Sarah M Mitchell; Lisa L Smith; Amy J Wagner; Chelsey A Raymond; Larry J Schaaf; Mitch A Phelps; Miguel A Villalona-Calero; Michael R Grever; John C Byrd
Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(35):6012-8.
2009: Kristie A Blum; Anjani Advani; Louis Fernandez; Richard Van Der Jagt; Joseph Brandwein; Suman Kambhampati; Jeannine Kassis; Melanie Davis; Claire Bonfils; Marja Dubay; Julie Dumouchel; Michel Drouin; David M Lucas; Robert E Martell; John C Byrd
Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia.
British journal of haematology 2009;147(4):507-14.
2009: Mehdi Hamadani; Don M Benson; Craig C Hofmeister; Patrick J Elder; William Blum; Pierluigi Porcu; Ramiro Garzon; Kristie A Blum; Thomas S Lin; Guido Marcucci; Steven M Devine
Allogeneic stem cell transplantation for patients with relapsed chemorefractory aggressive non-hodgkin lymphomas.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2009;15(5):547-53.
2009: Mitch A Phelps; Thomas S Lin; Amy J Johnson; Eunju Hurh; Darlene M Rozewski; Katherine L Farley; Di Wu; Kristie A Blum; Beth Fischer; Sarah M Mitchell; Mollie E Moran; Michelle Brooker-McEldowney; Nyla A Heerema; David Jarjoura; Larry J Schaaf; John C Byrd; Michael R Grever; James T Dalton
Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia.
Blood 2009;113(12):2637-45.
2009: Kristie A Blum; Mehdi Hamadani; Gary S Phillips; Gerard Lozanski; Amy J Johnson; David M Lucas; Lisa L Smith; Robert A Baiocchi; Thomas S Lin; Pierluigi Porcu; Steven M Devine; John C Byrd
Prolonged myelosuppression with clofarabine in the treatment of patients with relapsed or refractory, aggressive non-Hodgkin lymphoma.
Leukemia & lymphoma 2009;50(3):349-56.
2009: Lapo Alinari; Valerie L White; Christian T Earl; Timothy P Ryan; Jeffrey S Johnston; James T Dalton; Amy K Ferketich; Raymond Lai; David M Lucas; Pierluigi Porcu; Kristie A Blum; John C Byrd; Robert A Baiocchi
Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma.
mAbs 2009;1(1):31-40.
2008: Mehdi Hamadani; Don M Benson; Thomas S Lin; Pierluigi Porcu; Kristie A Blum; Steven M Devine
High-dose therapy and autologous stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma.
European journal of haematology 2008;81(6):425-31.
2008: Mehdi Hamadani; Farrukh T Awan; Patrick Elder; Thomas S Lin; Pierluigi Porcu; Don M Benson; Kristie A Blum; Steven M Devine
Feasibility of allogeneic hematopoietic stem cell transplantation for follicular lymphoma undergoing transformation to diffuse large B-cell lymphoma.
Leukemia & lymphoma 2008;49(10):1893-8.
2008: Qing Liu; Katherine L Farley; Amy J Johnson; Natarajan Muthusamy; Craig C Hofmeister; Kristie A Blum; Larry J Schaaf; Michael R Grever; John C Byrd; James T Dalton; Mitch A Phelps
Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.
Therapeutic drug monitoring 2008;30(5):620-7.
2008: Jeffrey S Johnston; Mitch A Phelps; Kristie A Blum; William Blum; Michael R Grever; Katherine L Farley; James T Dalton
Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;871(1):15-21.
2007: Kristie A Blum; Donn Young; Sarah Broering; Margaret S Lucas; Beth Fischer; Thomas S Lin; Michael R Grever; John C Byrd
Computed tomography scans do not improve the predictive power of 1996 national cancer institute sponsored working group chronic lymphocytic leukemia response criteria.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(35):5624-9.
2007: Kristie A Blum; Jeffrey L Johnson; Donna Niedzwiecki; George P Canellos; Bruce D Cheson; Nancy L Bartlett
Single agent bortezomib in the treatment of relapsed and refractory Hodgkin lymphoma: cancer and leukemia Group B protocol 50206.
Leukemia & lymphoma 2007;48(7):1313-9.
2007: John C Byrd; Thomas S Lin; James T Dalton; Di Wu; Mitch A Phelps; Beth Fischer; Mollie Moran; Kristie A Blum; Brad H Rovin; Michelle Brooker-McEldowney; Sarah Broering; Larry J Schaaf; Amy J Johnson; David M Lucas; Nyla A Heerema; Gerard Lozanski; Donn C Young; Jose-Ramon Suarez; A Dimitrios Colevas; Michael R Grever
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia.
Blood 2007;109(2):399-404.
2006: Kristie A Blum; Jeffrey L Johnson; Donna Niedzwiecki; Lawrence D Piro; Alan Saven; Bruce A Peterson; John C Byrd; Bruce D Cheson
Prolonged follow-up after initial therapy with 2-chlorodeoxyadenosine in patients with indolent non-Hodgkin lymphoma: results of Cancer and Leukemia Group B Study 9153.
Cancer 2006;107(12):2817-25.
2004: Kristie A Blum; Gerard Lozanski; John C Byrd
Adult Burkitt leukemia and lymphoma.
Blood 2004;104(10):3009-20.
2004: Kristie A Blum; Nancy L Bartlett
90Yttrium-ibritumomab tiuxetan: a novel treatment for non-Hodgkin's lymphoma.
Expert opinion on biological therapy 2004;4(8):1323-31.
2003: Kristie A Blum; Nancy L Bartlett
Antibodies for the treatment of diffuse large cell lymphoma.
Seminars in oncology 2003;30(4):448-56.
2002: Paula M Fracasso; Kristie A Blum; Benjamin R Tan; Carole L Fears; Nancy L Bartlett; Matthew A Arquette; Romnee S Clark
Phase I study of pegylated liposomal doxorubicin and gemcitabine in patients with advanced malignancies.
Cancer 2002;95(10):2223-9.