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Tomoyuki Shirai

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Tang MingXi; Asamoto Makoto; Ogawa Kumiko; Naiki-Ito Aya; Sato Shinya; Takahashi Satoru; Shirai Tomoyuki
Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor.
Takahashi Satoru; Takeshita Kentaro; Seeni Azman; Sugiura Satoshi; Tang Mingxi; Sato Shin-ya; Kuriyama Hiroki; Nakadate Masao; Abe Koichi; Maeno Yoshitaka; Nagao Masataka; Shirai Tomoyuki
Suppression of prostate cancer in a transgenic rat model via gamma-tocopherol activation of caspase signaling.
Ogawa Kumiko; Nabae Kyoko; Wang Jianqing; Wake Kanako; Watanabe So-ichi; Kawabe Mayumi; Fujiwara Osamu; Takahashi Satoru; Ichihara Toshio; Tamano Seiko; Shirai Tomoyuki
Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats.

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All Publications

2009: Tang MingXi; Asamoto Makoto; Ogawa Kumiko; Naiki-Ito Aya; Sato Shinya; Takahashi Satoru; Shirai Tomoyuki
Induction of apoptosis in the LNCaP human prostate carcinoma cell line and prostate adenocarcinomas of SV40T antigen transgenic rats by the Bowman-Birk inhibitor.
Pathology international 2009;59(11):790-6.
2009: Takahashi Satoru; Takeshita Kentaro; Seeni Azman; Sugiura Satoshi; Tang Mingxi; Sato Shin-ya; Kuriyama Hiroki; Nakadate Masao; Abe Koichi; Maeno Yoshitaka; Nagao Masataka; Shirai Tomoyuki
Suppression of prostate cancer in a transgenic rat model via gamma-tocopherol activation of caspase signaling.
The Prostate 2009;69(6):644-51.
2009: Ogawa Kumiko; Nabae Kyoko; Wang Jianqing; Wake Kanako; Watanabe So-ichi; Kawabe Mayumi; Fujiwara Osamu; Takahashi Satoru; Ichihara Toshio; Tamano Seiko; Shirai Tomoyuki
Effects of gestational exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular phones: Lack of embryotoxicity and teratogenicity in rats.
Bioelectromagnetics 2009;30(3):205-12.
2009: Sugiyama Masaya; Tanaka Yasuhito; Kurbanov Fuat; Maruyama Isao; Shimada Takashi; Takahashi Satoru; Shirai Tomoyuki; Hino Keisuke; Sakaida Isao; Mizokami Masashi
Direct cytopathic effects of particular hepatitis B virus genotypes in severe combined immunodeficiency transgenic with urokinase-type plasminogen activator mouse with human hepatocytes.
Gastroenterology 2009;136(2):652-62.e3.
2009: Suzuki Shugo; Takeshita Kentaro; Asamoto Makoto; Takahashi Satoru; Kandori Hitoshi; Tsujimura Kazunari; Saito Fumiyo; Masuko Kazuo; Shirai Tomoyuki
High mobility group box associated with cell proliferation appears to play an important role in hepatocellular carcinogenesis in rats and humans.
Toxicology 2009;255(3):160-70.
2008: Kawabe Mayumi; Futakuchi Mitsuru; Tamano Seiko; Shirai Tomoyuki; Hirose Masao
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesis model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(8):2758-63.
2008: Tanaka Yasuhito; Sanchez Laura V; Sugiyama Masaya; Sakamoto Tomoyuki; Kurbanov Fuat; Tatematsu Kanako; Roman Sonia; Takahashi Satoru; Shirai Tomoyuki; Panduro Arturo; Mizokami Masashi
Characteristics of hepatitis B virus genotype G coinfected with genotype H in chimeric mice carrying human hepatocytes.
Virology 2008;376(2):408-15.
2008: Hokaiwado Naomi; Takeshita Fumitaka; Naiki-Ito Aya; Asamoto Makoto; Ochiya Takahiro; Shirai Tomoyuki
Glutathione S-transferase Pi mediates proliferation of androgen-independent prostate cancer cells.
Carcinogenesis 2008;29(6):1134-8.
2008: Kawai Noriyasu; Futakuchi Mitsuru; Yoshida Tatsuro; Ito Akira; Sato Shinya; Naiki Taku; Honda Hiroyuki; Shirai Tomoyuki; Kohri Kenjiro
Effect of heat therapy using magnetic nanoparticles conjugated with cationic liposomes on prostate tumor in bone.
The Prostate 2008;68(7):784-92.
2008: Hikosaka Atsuya; Ogawa Kumiko; Sugiura Satoshi; Asamoto Makoto; Takeshita Fumitaka; Sato Shin-Ya; Nakanishi Makoto; Kohri Kenjiro; Shirai Tomoyuki
Susceptibility of p27 kip1 knockout mice to urinary bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine may not simply be due to enhanced proliferation.
International journal of cancer. Journal international du cancer 2008;122(6):1222-8.
2008: Sato Shinya; Futakuchi Mitsuru; Ogawa Kumiko; Asamoto Makoto; Nakao Kimihisa; Asai Kiyofumi; Shirai Tomoyuki
Transforming growth factor beta derived from bone matrix promotes cell proliferation of prostate cancer and osteoclast activation-associated osteolysis in the bone microenvironment.
Cancer science 2008;99(2):316-23.
2008: Nabae Kyoko; Hayashi Shim-Mo; Kawabe Mayumi; Ichihara Toshio; Hagiwara Akihiro; Tamano Seiko; Tsushima Yoko; Uchida Koji; Koda Takatoshi; Nakamura Mikio; Ogawa Kumiko; Shirai Tomoyuki
A 90-day oral toxicity study of purple corn color, a natural food colorant, in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(2):774-80.
2008: Seeni Azman; Takahashi Satoru; Takeshita Kentaro; Tang Mingxi; Sugiura Satoshi; Sato Shin-ya; Shirai Tomoyuki
Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model.
Asian Pacific journal of cancer prevention : APJCP 2008;9(1):7-14.
2008: Shirai Tomoyuki
Significance of chemoprevention for prostate cancer development: experimental in vivo approaches to chemoprevention.
Pathology international 2008;58(1):1-16.
2007: Naiki-Ito Aya; Asamoto Makoto; Hokaiwado Naomi; Takahashi Satoru; Yamashita Hiroko; Tsuda Hiroyuki; Ogawa Kumiko; Shirai Tomoyuki
Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens.
Cancer research 2007;67(23):11353-8.
2007: Shirai Tomoyuki; Ichihara Toshio; Wake Kanako; Watanabe So-ichi; Yamanaka Yukio; Kawabe Mayumi; Taki Masao; Fujiwara Osamu; Wang Jianqing; Takahashi Satoru; Tamano Seiko
Lack of promoting effects of chronic exposure to 1.95-GHz W-CDMA signals for IMT-2000 cellular system on development of N-ethylnitrosourea-induced central nervous system tumors in F344 rats.
Bioelectromagnetics 2007;28(7):562-72.
2007: Hokaiwado Naomi; Asamoto Makoto; Futakuchi Mitsuru; Ogawa Kumiko; Takahashi Satoru; Shirai Tomoyuki
Both early and late stages of hepatocarcinogenesis are enhanced in Cx32 dominant negative mutant transgenic rats with disrupted gap junctional intercellular communication.
The Journal of membrane biology 2007;218(1-3):101-6.
2007: Tsuda Hiroyuki; Iigo Masaaki; Takasuka Nobuo; Ueda Shinobu; Ohshima Yutaka; Fukamachi Katsumi; Shirai Tomoyuki; Hirano Sachiko; Matsuda Eiji; Wakabayashi Keiji
Possible enhancing activity of diacylglycerol on 4-nitroquinoline 1-oxide induced carcinogenesis of the tongue in human c-Ha-ras proto-oncogene transgenic rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2007;45(6):1013-9.
2007: Sugiyama Masaya; Tanaka Yasuhito; Sakamoto Tomoyuki; Maruyama Isao; Shimada Takashi; Takahashi Satoru; Shirai Tomoyuki; Kato Hideaki; Nagao Masataka; Miyakawa Yuzo; Mizokami Masashi
Early dynamics of hepatitis B virus in chimeric mice carrying human hepatocytes monoinfected or coinfected with genotype G.
Hepatology (Baltimore, Md.) 2007;45(4):929-37.
2007: Tang MingXi; Ogawa Kumiko; Asamoto Makoto; Hokaiwado Naomi; Seeni Azman; Suzuki Shugo; Takahashi Satoru; Tanaka Takuji; Ichikawa Kazuhito; Shirai Tomoyuki
Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate (TRAP) and human prostate carcinoma cells.
Cancer science 2007;98(4):471-7.
2006: Imai Norio; Doi Yuko; Nabae Kyoko; Tamano Seiko; Hagiwara Akihiro; Kawabe Mayumi; Ichihara Toshio; Ogawa Kumiko; Shirai Tomoyuki
Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats.
The Journal of toxicological sciences 2006;31(4):357-70.
2006: Nabae Kyoko; Doi Yuko; Takahashi Satoru; Ichihara Toshio; Toda Chitose; Ueda Koji; Okamoto Yoshinori; Kojima Nakao; Tamano Seiko; Shirai Tomoyuki
Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced with folic acid in rats: enhancement of male reproductive toxicity of DEHP is associated with an increase of the mono-derivative.
Reproductive toxicology (Elmsford, N.Y.) 2006;22(3):411-7.
2006: Tsujimura Kazunari; Asamoto Makoto; Suzuki Shugo; Hokaiwado Naomi; Ogawa Kumiko; Shirai Tomoyuki
Prediction of carcinogenic potential by a toxicogenomic approach using rat hepatoma cells.
Cancer science 2006;97(10):1002-10.
2006: Said Mahmoud M; Hokaiwado Naomi; Tang Mingxi; Ogawa Kumiko; Suzuki Shugo; Ghanem Hala M; Esmat Amr Y; Asamoto Makoto; Refaie Fawzia M; Shirai Tomoyuki
Inhibition of prostate carcinogenesis in probasin/SV40 T antigen transgenic rats by leuprorelin, a luteinizing hormone-releasing hormone agonist.
Cancer science 2006;97(6):459-67.
2006: Kawai Noriyasu; Ito Akira; Nakahara Yoko; Honda Hiroyuki; Kobayashi Takeshi; Futakuchi Mitsuru; Shirai Tomoyuki; Tozawa Keiichi; Kohri Kenjiro
Complete regression of experimental prostate cancer in nude mice by repeated hyperthermia using magnetite cationic liposomes and a newly developed solenoid containing a ferrite core.
The Prostate 2006;66(7):718-27.
2006: Ogawa Kumiko; Masutani Mitsuko; Kato Koji; Tang Mingxi; Kamada Nobuo; Suzuki Hiroshi; Nakagama Hitoshi; Sugimura Takashi; Shirai Tomoyuki
Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice.
Cancer letters 2006;236(1):32-8.
2006: Suzuki Shugo; Takahashi Satoru; Takahashi Seishiro; Takeshita Kentaro; Hikosaka Atsuya; Wakita Toshiaki; Nishiyama Naoki; Fujita Tamio; Okamura Takehiko; Shirai Tomoyuki
Expression of prothymosin alpha is correlated with development and progression in human prostate cancers.
The Prostate 2006;66(5):463-9.
2006: Doi Y; Ichihara T; Hagiwara A; Imai N; Tamano S; Orikoshi H; Ogasawara K; Sasaki Y; Nakamura M; Shirai T
A ninety-day oral toxicity study of a new type of processed gum arabic, from Acacia tree (Acacia senegal) exudates, in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(4):560-6.
2006: Kuribayashi Masanori; Asamoto Makoto; Suzuki Shugo; Hokaiwado Naomi; Ogawa Kumiko; Shirai Tomoyuki
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) rat hepatocarcinogenesis by caffeine, a CYP1A2 inducer, points to complex counteracting influences.
Cancer letters 2006;232(2):289-99.
2006: Takahashi Seishiro; Suzuki Shugo; Takahashi Satoru; Inaguma Shingo; Asamoto Makoto; Shirai Tomoyuki
Differences between latent and clinical prostate carcinomas: lower cell proliferation activity in latent cases.
The Prostate 2006;66(2):211-7.
2006: Kawabe Mayumi; Sano Masashi; Hagiwara Akihiro; Tamano Seiko; Suzuki Shugo; Shirai Tomoyuki
Lack of carcinogenicity of L-isoleucine in F344/DuCrj rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2006;44(2):278-85.
2006: Hikosaka Atsuya; Futakuchi Mitsuru; Ogiso Tadashi; Suzuki Shugo; Kohri Kenjiro; Shirai Tomoyuki
Lack of prophylactic effect of incadronate on skeletal lesions associated with implants of prostate cancer.
European urology 2006;49(1):176-82.
2005: Kuribayashi Masanori; Wang Jianqing; Fujiwara Osamu; Doi Yuko; Nabae Kyoko; Tamano Seiko; Ogiso Tadashi; Asamoto Makoto; Shirai Tomoyuki
Lack of effects of 1439 MHz electromagnetic near field exposure on the blood-brain barrier in immature and young rats.
Bioelectromagnetics 2005;26(7):578-88.
2005: Kawai Noriyasu; Ito Akira; Nakahara Yoko; Futakuchi Mitsuru; Shirai Tomoyuki; Honda Hiroyuki; Kobayashi Takeshi; Kohri Kenjiro
Anticancer effect of hyperthermia on prostate cancer mediated by magnetite cationic liposomes and immune-response induction in transplanted syngeneic rats.
The Prostate 2005;64(4):373-81.
2005: Hagiwara A; Yoshino H; Sano M; Kawabe M; Tamano S; Sakaue K; Nakamura M; Tada M; Imaida K; Shirai T
Thirteen-week feeding study of thaumatin (a natural proteinaceous sweetener), sterilized by electron beam irradiation, in Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(8):1297-302.
2005: Nabae K; Ichihara T; Hagiwara A; Hirota T; Toda Y; Tamano S; Nishino M; Ogasawara T; Sasaki Y; Nakamura M; Shirai T
A 90-day oral toxicity study of beta-carotene derived from Blakeslea trispora, a natural food colorant, in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2005;43(7):1127-33.
2005: Ikeda Yoshihisa; Cho Young-Man; Takahashi Satoru; Tang Mingxi; Asamoto Makoto; Ogawa Kumiko; Shirai Tomoyuki
Equivocal impact of transplacental and lactational exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, on prostate and colon lesion development in F344 rats.
Cancer letters 2005;224(1):23-30.
2005: Lynch Conor C; Hikosaka Atsuya; Acuff Heath B; Martin Michelle D; Kawai Noriyasu; Singh Rakesh K; Vargo-Gogola Tracy C; Begtrup Jennifer L; Peterson Todd E; Fingleton Barbara; Shirai Tomoyuki; Matrisian Lynn M; Futakuchi Mitsuru
MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.
Cancer cell 2005;7(5):485-96.
2005: Kandori Hitoshi; Suzuki Shugo; Asamoto Makoto; Murasaki Toshiya; Mingxi Tang; Ogawa Kumiko; Shirai Tomoyuki
Influence of atrazine administration and reduction of calorie intake on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats.
Cancer science 2005;96(4):221-6.
2005: Okamoto Tetsu; Yamada Tamaki; Kuno Atsushi; Ogawa Kumiko; Tang Mingxi; Sano Hitoshi; Ohara Hirotaka; Nakao Haruhisa; Kataoka Hiromi; Shirai Tomoyuki; Itoh Makoto
FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.
Pancreas 2005;30(3):e64-70.
2005: Ogawa Kumiko; Asamoto Makoto; Suzuki Shugo; Tsujimura Kazunari; Shirai Tomoyuki
Downregulation of apoptosis revealed by laser microdissection and cDNA microarray analysis of related genes in rat liver preneoplastic lesions.
Medical molecular morphology 2005;38(1):23-9.
2005: Ichihara Toshio; Miyashita Kayoko; Kawabe Mayumi; Imaida Katsumi; Asamoto Makoto; Ogiso Tadashi; Tamano Seiko; Hirose Masao; Shirai Tomoyuki
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat.
The Journal of toxicological sciences 2005;30(1):1-6.
2005: Ito Aya; Asamoto Makoto; Hokaiwado Naomi; Takahashi Satoru; Shirai Tomoyuki
Tbx3 expression is related to apoptosis and cell proliferation in rat bladder both hyperplastic epithelial cells and carcinoma cells.
Cancer letters 2005;219(1):105-12.
2005: Shirai Tomoyuki; Kawabe Mayumi; Ichihara Toshio; Fujiwara Osamu; Taki Masao; Watanabe So-ichi; Wake Kanako; Yamanaka Yukio; Imaida Katsumi; Asamoto Makoto; Tamano Seiko
Chronic exposure to a 1.439 GHz electromagnetic field used for cellular phones does not promote N-ethylnitrosourea induced central nervous system tumors in F344 rats.
Bioelectromagnetics 2005;26(1):59-68.
2005: Hokaiwado Naomi; Asamoto Makoto; Ogawa Kumiko; Shirai Tomoyuki
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Toxicologic pathology 2005;33(6):695-701.
2005: Zhao Laiyuan; Futakuchi Mitsuru; Suzuki Shugo; Ohhara Yoshiaki; Hashimoto Takashi; Suzuki Tatsuya; Manabe Tadao; Shirai Tomoyuki
Kinetics of marked development of lung metastasis of rat prostatic carcinomas transplanted in syngeneic rats.
Clinical & experimental metastasis 2005;22(4):309-18.
2005: Ozaki Masakazu; Ozaki Keisuke; Watanabe Tomoyuki; Uwagawa Satoshi; Okuno Yasuyoshi; Shirai Tomoyuki
Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains.
Toxicologic pathology 2005;33(2):267-71.
2004: Ohnishi Hiroyuki; Asamoto Makoto; Tujimura Kazunari; Hokaiwado Naomi; Takahashi Satoru; Ogawa Kumiko; Kuribayashi Masanori; Ogiso Tadashi; Okuyama Harumi; Shirai Tomoyuki
Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo.
Cancer science 2004;95(12):936-42.
2004: Inaguma Shingo; Takahashi Satoru; Imaida Katsumi; Suzuki Shugo; Shirai Tomoyuki
p-Nonylphenol pretreatment during the late neonatal period has no effect on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats.
Cancer letters 2004;212(2):159-66.
2004: Asamoto Makoto; Hokaiwado Naomi; Murasaki Toshiya; Shirai Tomoyuki
Connexin 32 dominant-negative mutant transgenic rats are resistant to hepatic damage by chemicals.
Hepatology (Baltimore, Md.) 2004;40(1):205-10.
2004: Ogawa Kumiko; Tada Toyohiro; Takahashi Satoru; Sugiyama Naotake; Inaguma Shingo; Takahashi Seishiro S; Shirai Tomoyuki
Malignant solitary fibrous tumor of the meninges.
Virchows Archiv : an international journal of pathology 2004;444(5):459-64.
2004: Orita Shinichiro; Hirose Masao; Takahashi Satoru; Imaida Katsumi; Ito Nobuyuki; Shudo Koichi; Ohigashi Hajime; Murakami Akira; Shirai Tomoyuki
Modifying effects of 1'-acetoxychavicol acetate (ACA) and the novel synthetic retinoids Re-80, Am-580 and Am-55P in a two-stage carcinogenesis model in female rats.
Toxicologic pathology 2004;32(2):250-7.
2004: Suzuki Shugo; Asamoto Makoto; Tsujimura Kazunari; Shirai Tomoyuki
Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue.
Carcinogenesis 2004;25(3):439-43.
2004: Hikosaka Atsuya; Asamoto Makoto; Hokaiwado Naomi; Kato Koji; Kuzutani Kazuya; Kohri Kenjiro; Shirai Tomoyuki
Inhibitory effects of soy isoflavones on rat prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 2004;25(3):381-7.
2004: Ogawa Kumiko; Tada Toyohiro; Takeuchi Yuuki; Suenaga Masahiro; Suzuki Shugo; Shirai Tomoyuki
Reactive angioendotheliomatosis of the intestine.
The American journal of surgical pathology 2004;28(2):257-61.
2004: Hokaiwado Naomi; Asamoto Makoto; Tsujimura Kazunari; Hirota Takeshi; Ichihara Toshio; Satoh Takatomo; Shirai Tomoyuki
Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system.
Cancer science 2004;95(2):123-30.
2004: Tsutsumi Tomoko; Ichihara Toshio; Kawabe Mayumi; Yoshino Hiroko; Asamoto Makoto; Suzuki Shugo; Shirai Tomoyuki
Renal toxicity induced by folic acid is associated with the enhancement of male reproductive toxicity of di(n-butyl)phthalate in rats.
Reproductive toxicology (Elmsford, N.Y.) 2004;18(1):35-42.
2004: Futakuchi Mitsuru; Ogawa Kumiko; Tamano Seiko; Takahashi Seishiro; Shirai Tomoyuki
Suppression of metastasis by nuclear factor kappaB inhibitors in an in vivo lung metastasis model of chemically induced hepatocellular carcinoma.
Cancer science 2004;95(1):18-24.
2003: Hagiwara Akihiro; Sano Masashi; Ichihara Toshio; Yoshino Hiroko; Miyata Emiko; Tamano Seiko; Aoki Hiromitsu; Yukawa Chiyoki; Koda Takatoshi; Nakamura Mikio; Shirai Tomoyuki
Four-week oral toxicity study of 1-carboxy-5,7-dibromo-6-hydroxy-2,3,4-trichloroxanthone (HXCA), an impurity of Phloxine B, in F344 rats.
The Journal of toxicological sciences 2003;28(5):445-53.
2003: Hokaiwado Naomi; Asamoto Makoto; Cho Young-Man; Tsuda Hiroyuki; Shirai Tomoyuki
Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats.
Cancer science 2003;94(12):1042-5.
2003: Inaguma Shingo; Takahashi Satoru; Ohnishi Hiroyuki; Suzuki Shugo; Cho Young-Man; Shirai Tomoyuki
High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) prostate carcinogenesis.
Cancer science 2003;94(11):974-9.
2003: Hagiwara Akihiro; Imai Norio; Doi Yuko; Nabae Kyoko; Hirota Takeshi; Yoshino Hiroko; Kawabe Mayumi; Tsushima Yoko; Aoki Hiromitsu; Yasuhara Kazuo; Koda Takatoshi; Nakamura Mikio; Shirai Tomoyuki
Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats.
Cancer letters 2003;199(1):9-17.
2003: Ichihara Toshio; Yoshino Hiroko; Imai Norio; Tsutsumi Tomoko; Kawabe Mayumi; Tamano Seiko; Inaguma Shingo; Suzuki Shugo; Shirai Tomoyuki
Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats.
The Journal of toxicological sciences 2003;28(3):165-71.
2003: Hagiwara A; Imai N; Ichihara T; Sano M; Tamano S; Aoki H; Yasuhara K; Koda T; Nakamura M; Shirai T
A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(8):1157-64.
2003: Cheng Jing Lei; Futakuchi Mitsuru; Ogawa Kumiko; Iwata Toshio; Kasai Masaaki; Tokudome Shinkan; Hirose Masao; Shirai Tomoyuki
Dose response study of conjugated fatty acid derived from safflower oil on mammary and colon carcinogenesis pretreated with 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH) in female Sprague-Dawley rats.
Cancer letters 2003;196(2):161-8.
2003: Akagi Keisuke; Sano Masashi; Ogawa Kumiko; Hirose Masao; Goshima Hideo; Shirai Tomoyuki
Involvement of toxicity as an early event in urinary bladder carcinogenesis induced by phenethyl isothiocyanate, benzyl isothiocyanate, and analogues in F344 rats.
Toxicologic pathology 2003;31(4):388-96.
2003: Takeshita Fumitaka; Ogawa Kumiko; Asamoto Makoto; Shirai Tomoyuki
Mechanistic approach of contrasting modifying effects of caffeine on carcinogenesis in the rat colon and mammary gland induced with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Cancer letters 2003;194(1):25-35.
2003: Ito Aya; Asamoto Makoto; Hokaiwado Naomi; Shirai Tomoyuki
Regulation of cell proliferation by induction of p21/WAF1 in rat bladder carcinoma cells using the Cre--loxP system.
Cancer letters 2003;193(2):183-8.
2003: Cheng Jinglei; Ogawa Kumiko; Kuriki Kiyonori; Yokoyama Yoshifumi; Kamiya Takeshi; Seno Kyoji; Okuyama Harumi; Wang Jingwen; Luo Chenhong; Fujii Toshiko; Ichikawa Hiromitsu; Shirai Tomoyuki; Tokudome Shinkan
Increased intake of n-3 polyunsaturated fatty acids elevates the level of apoptosis in the normal sigmoid colon of patients polypectomized for adenomas/tumors.
Cancer letters 2003;193(1):17-24.
2003: Kuno Atsushi; Yamada Tamaki; Masuda Kazuhiko; Ogawa Kumiko; Sogawa Mitsue; Nakamura Soichi; Nakazawa Takahiro; Ohara Hirotaka; Nomura Tomoyuki; Joh Takashi; Shirai Tomoyuki; Itoh Makoto
Angiotensin-converting enzyme inhibitor attenuates pancreatic inflammation and fibrosis in male Wistar Bonn/Kobori rats.
Gastroenterology 2003;124(4):1010-9.
2003: Sugiura Satoshi; Ogawa Kumiko; Hirose Masao; Takeshita Fumitaka; Asamoto Makoto; Shirai Tomoyuki
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
Carcinogenesis 2003;24(3):547-53.
2003: Cho Young-Man; Takahashi Satoru; Asamoto Makoto; Suzuki Shugo; Inaguma Shingo; Hokaiwado Naomi; Shirai Tomoyuki
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
Cancer science 2003;94(2):153-7.
2003: Takahashi Satoru; Suzuki Shugo; Inaguma Shingo; Ikeda Yoshihisa; Cho Young-Man; Hayashi Norio; Inoue Takahiro; Sugimura Yoshiki; Nishiyama Naoki; Fujita Tamio; Chao Julie; Ushijima Toshikazu; Shirai Tomoyuki
Down-regulated expression of prostasin in high-grade or hormone-refractory human prostate cancers.
The Prostate 2003;54(3):187-93.
2003: Ito Nobuyuki; Tamano Seiko; Shirai Tomoyuki
A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals.
Cancer science 2003;94(1):3-8.
2002: Yoshino Hiroko; Ichihara Toshio; Kawabe Mayumi; Imai Norio; Hagiwara Akihiro; Asamoto Makoto; Shirai Tomoyuki
Lack of significant alteration in the prostate or testis of F344 rat offspring after transplacental and lactational exposure to bisphenol A.
The Journal of toxicological sciences 2002;27(5):433-9.
2002: Shirai Tomoyuki; Asamoto Makoto; Takahashi Satoru; Imaida Katsumi
Diet and prostate cancer.
Toxicology 2002;181-182():89-94.
2002: Yada Hideaki; Hirose Masao; Tamano Seiko; Kawabe Mayumi; Sano Masashi; Takahashi Satoru; Futakuchi Mitsuru; Miki Tokutaro; Shirai Tomoyuki
Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 2002;93(12):1299-307.
2002: Hirose Masao; Yamaguchi Tsuyoshi; Mizoguchi Yasumoto; Akagi Keisuke; Futakuchi Mitsuru; Shirai Tomoyuki
Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses.
Cancer letters 2002;188(1-2):163-70.
2002: Suzuki Shugo; Takahashi Satoru; Asamoto Makoto; Inaguma Shingo; Ogiso Tadashi; Hirose Masao; Shirai Tomoyuki
Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.
Cancer letters 2002;185(1):39-45.
2002: Futakuchi Mitsuru; Ogawa Kumiko; Sano Masashi; Tamano Seiko; Takeshita Fumitaka; Shirai Tomoyuki
Suppression of lung metastasis by aspirin but not indomethacin in an in vivo model of chemically induced hepatocellular carcinoma.
Japanese journal of cancer research : Gann 2002;93(10):1175-81.
2002: Shirai T; Kato K; Futakuchi M; Takahashi S; Suzuki S; Imaida K; Asamoto M
Organ differences in the enhancing potential of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on carcinogenicity in the prostate, colon and pancreas.
Mutation research 2002;506-507():129-36.
2002: Takahashi Satoru; Inaguma Shingo; Sakakibara Michihisa; Cho Young-Man; Suzuki Shugo; Ikeda Yoshihisa; Cui Lin; Shirai Tomoyuki
DNA methylation in the androgen receptor gene promoter region in rat prostate cancers.
The Prostate 2002;52(1):82-8.
2002: Takahashi Satoru; Inaguma Shingo; Cho Young-Man; Imaida Katsumi; Wang Jianqing; Fujiwara Osamu; Shirai Tomoyuki
Lack of mutation induction with exposure to 1.5 GHz electromagnetic near fields used for cellular phones in brains of Big Blue mice.
Cancer research 2002;62(7):1956-60.
2002: Futakuchi Mitsuru; Cheng Jing Lei; Hirose Masao; Kimoto Naoya; Cho Young Man; Iwata Toshio; Kasai Masaaki; Tokudome Shinkan; Shirai Tomoyuki
Inhibition of conjugated fatty acids derived from safflower or perilla oil of induction and development of mammary tumors in rats induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Cancer letters 2002;178(2):131-9.
2002: Takahashi S; Suzuki S; Inaguma S; Cho Y-M; Ikeda Y; Hayashi N; Inoue T; Sugimura Y; Nishiyama N; Fujita T; Ushijima T; Shirai T
Down-regulation of Lsm1 is involved in human prostate cancer progression.
British journal of cancer 2002;86(6):940-6.
2002: Asamoto Makoto; Hokaiwado Naomi; Cho Young-Man; Shirai Tomoyuki
Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control.
Carcinogenesis 2002;23(3):463-7.
2002: Hagiwara Akihiro; Yoshino Hiroko; Ichihara Toshio; Kawabe Mayumi; Tamano Seiko; Aoki Hiromitsu; Koda Takatoshi; Nakamura Mikio; Imaida Katsumi; Ito Nobuyuki; Shirai Tomoyuki
Prevention by natural food anthocyanins, purple sweet potato color and red cabbage color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine.
The Journal of toxicological sciences 2002;27(1):57-68.
2002: Futakuchi Mitsuru; Hirose Masao; Imaida Katsumi; Takahashi Satoru; Ogawa Kumiko; Asamoto Makoto; Miki Tokutaro; Shirai Tomoyuki
Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.
Carcinogenesis 2002;23(2):283-7.
2002: Takahashi Satoru; Suzuki Shugo; Inaguma Shingo; Ikeda Yoshihisa; Cho Young-Man; Nishiyama Naoki; Fujita Tamio; Inoue Takahiro; Hioki Takuichi; Sugimura Yoshiki; Ushijima Toshikazu; Shirai Tomoyuki
Down-regulation of human X-box binding protein 1 (hXBP-1) expression correlates with tumor progression in human prostate cancers.
The Prostate 2002;50(3):154-61.
2002: Hirose Masao; Nishikawa Akiyoshi; Shibutani Makoto; Imai Toshio; Shirai Tomoyuki
Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats.
Environmental and molecular mutagenesis 2002;39(2-3):271-8.
2002: Hagiwara Akihiro; Sano Masashi; Tanaka Hikaru; Kawabe Mayumi; Tamano Seiko; Kadota Tadaomi; Yanagisawa Toshihiko; Maemura Shunichi; Ito Nobuyuki; Shirai Tomoyuki
Lack of enhancing effect of two Kampo medicines, Sho-saiko-to (TJ-9) and Sairei-to (TJ-114), on rat urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Teratogenesis, carcinogenesis, and mutagenesis 2002;22(1):41-50.
2001: Imaida K; Kuzutani K; Wang J; Fujiwara O; Ogiso T; Kato K; Shirai T
Lack of promotion of 7,12-dimethylbenz[a]anthracene-initiated mouse skin carcinogenesis by 1.5 GHz electromagnetic near fields.
Carcinogenesis 2001;22(11):1837-41.
2001: Mori T; Imaida K; Tamano S; Sano M; Takahashi S; Asamoto M; Takeshita M; Ueda H; Shirai T
Beef tallow, but not perilla or corn oil, promotion of rat prostate and intestinal carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl.
Japanese journal of cancer research : Gann 2001;92(10):1026-33.
2001: Hagiwara A; Miyashita K; Nakanishi T; Sano M; Tamano S; Kadota T; Koda T; Nakamura M; Imaida K; Ito N; Shirai T
Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine.
Cancer letters 2001;171(1):17-25.
2001: Imaida K; Sano M; Tamano S; Asamoto M; Ogawa K; Futakuchi M; Shirai T
Organ dependent enhancement of rat 3,2'-dimethyl-4-aminobiphenyl (DMAB) carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): positive effects on the intestine but not the prostate.
Carcinogenesis 2001;22(8):1295-9.
2001: Hirose M; Hoshiya T; Mizoguchi Y; Nakamura A; Akagi K; Shirai T
Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats.
Cancer letters 2001;168(1):23-9.
2001: Kimoto N; Hirose M; Futakuchi M; Iwata T; Kasai M; Shirai T
Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats.
Cancer letters 2001;168(1):15-21.
2001: Asamoto M; Hokaiwado N; Cho Y M; Takahashi S; Ikeda Y; Imaida K; Shirai T
Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent.
Cancer research 2001;61(12):4693-700.
2001: Asamoto M; Hokaiwado N; Cho Y M; Ikeda Y; Takahashi S; Shirai T
Metastasizing neuroblastomas from taste buds in rats transgenic for the Simian virus 40 large T antigen under control of the probasin gene promoter.
Toxicologic pathology 2001;29(3):363-8.
2001: Hagiwara A; Takesada Y; Tanaka H; Tamano S; Hirose M; Ito N; Shirai T
Dose-dependent induction of glandular stomach preneoplastic and neoplastic lesions in male F344 rats treated with catechol chronically.
Toxicologic pathology 2001;29(2):180-6.
2001: Ogawa K; Nakanishi H; Takeshita F; Futakuchi M; Asamoto M; Imaida K; Tatematsu M; Shirai T
Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice.
International journal of cancer. Journal international du cancer 2001;91(6):797-802.
2001: Imaida K; Tamano S; Kato K; Ikeda Y; Asamoto M; Takahashi S; Nir Z; Murakoshi M; Nishino H; Shirai T
Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.
Carcinogenesis 2001;22(3):467-72.
2001: Hokaiwado N; Asamoto M; Cho Y M; Imaida K; Shirai T
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Cancer letters 2001;163(2):187-90.
2001: Ogawa K; Hirose M; Sugiura S; Cui L; Imaida K; Ogiso T; Shirai T
Dose-dependent promotion by phenylethyl isothiocyanate, a known chemopreventer, of two-stage rat urinary bladder and liver carcinogenesis.
Nutrition and cancer 2001;40(2):134-9.
2000: Imaida K; Shirai T
[Endocrine disrupting chemicals and carcinogenesis--breast, testis and prostate cancer]
Nippon rinsho. Japanese journal of clinical medicine 2000;58(12):2527-32.
2000: Tiwawech D; Hirose M; Futakuchi M; Lin C; Thamavit W; Ito N; Shirai T
Enhancing effects of Thai edible plants on 2-amino-3, 8-dimethylimidazo(4,5-f)quinoxaline-hepatocarcinogenesis in a rat medium-term bioassay.
Cancer letters 2000;158(2):195-201.
2000: Kato K; Takahashi S; Cui L; Toda T; Suzuki S; Futakuchi M; Sugiura S; Shirai T
Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis.
Japanese journal of cancer research : Gann 2000;91(8):786-91.
2000: Takahashi S; Ikeda Y; Orita S; Sakakibara M; Kimoto N; Suzuki S; Imaida K; Shirai T
Enhancing effects of 2-amino-4,5-diphenylthiazole-induced polycystic kidneys on renal carcinogenesis in rats treated with dimethylnitrosamine.
Toxicology and applied pharmacology 2000;167(1):12-7.
2000: Imaida K; Hagiwara A; Yoshino H; Tamano S; Sano M; Futakuchi M; Ogawa K; Asamoto M; Shirai T
Inhibitory effects of low doses of melatonin on induction of preneoplastic liver lesions in a medium-term liver bioassay in F344 rats: relation to the influence of electromagnetic near field exposure.
Cancer letters 2000;155(1):105-14.
2000: Hirose M; Yamaguchi T; Lin C; Kimoto N; Futakuchi M; Kono T; Nishibe S; Shirai T
Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats.
Cancer letters 2000;155(1):79-88.
2000: Maruyama H; Osada Y; Yoshida A; Futakuchi M; Kawaguchi H; Zhang R; Fu J; Shirai T; Kojima S; Ohta N
Protective mechanisms against the intestinal nematode Strongyloides venezuelensis in Schistosoma japonicum-infected mice.
Parasite immunology 2000;22(6):279-86.
2000: Shirai T; Takahashi S; Cui L; Futakuchi M; Kato K; Tamano S; Imaida K
Experimental prostate carcinogenesis - rodent models.
Mutation research 2000;462(2-3):219-26.
2000: Ito N; Imaida K; Asamoto M; Shirai T
Early detection of carcinogenic substances and modifiers in rats.
Mutation research 2000;462(2-3):209-17.
2000: Imaida K; Ogawa K; Takahashi S; Ito T; Yamaguchi T; Totsuka Y; Wakabayashi K; Tanaka K; Ito N; Shirai T
Delay of DNA-adduct repair and severe toxicity in xeroderma pigmentosum group A gene (XPA) deficient mice treated with 2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP).
Cancer letters 2000;150(1):63-9.
2000: Yaono M; Tamano S; Mori T; Kato K; Imaida K; Asamoto M; Shirai T
Lobe specific effects of testosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.
Cancer letters 2000;150(1):33-40.
2000: Takahashi S; Ikeda Y; Kimoto N; Okochi E; Cui L; Nagao M; Ushijima T; Shirai T
Mutation induction by mechanical irritation caused by uracil-induced urolithiasis in Big Blue rats.
Mutation research 2000;447(2):275-80.
2000: Zhang R; Suzuki T; Takahashi S; Yoshida A; Kawaguchi H; Maruyama H; Yabu Y; Fu J; Shirai T; Ohta N
Cloning and molecular characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistosoma japonicum.
Parasitology international 2000;48(3):232-42.
2000: Cui L; Takahashi S; Tada M; Kato K; Yamada Y; Kohri K; Shirai T
Immunohistochemical detection of carcinogen-DNA adducts in normal human prostate tissues transplanted into the subcutis of athymic nude mice: results with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 3,2'-dimethyl-4-aminobiphenyl (DMAB) and relation to cytochrome P450s and N-acetyltransferase activity.
Japanese journal of cancer research : Gann 2000;91(1):52-8.
2000: Ogawa K; Kimoto N; Asamoto M; Nakanishi M; Takahashi S; Shirai T
Aberrant expression of p27(Kip1) is associated with malignant transformation of the rat urinary bladder epithelium.
Carcinogenesis 2000;21(1):117-21.
2000: Kawabe M; Lin C; Kimoto N; Sano M; Hirose M; Shirai T
Modifying effects of propolis on MeIQx promotion of rat hepatocarcinogenesis and in a female rat two-stage carcinogenesis model after multiple carcinogen initiation.
Nutrition and cancer 2000;37(2):179-86.
1999: Kimoto N; Hirose M; Kawabe M; Satoh T; Miyataka H; Shirai T
Post-initiation effects of a super critical extract of propolis in a rat two-stage carcinogenesis model in female F344 rats.
Cancer letters 1999;147(1-2):221-7.
1999: Futakuchi M; Hirose M; Ogiso T; Kato K; Sano M; Ogawa K; Shirai T
Establishment of an in vivo highly metastatic rat hepatocellular carcinoma model.
Japanese journal of cancer research : Gann 1999;90(11):1196-202.
1999: Ikeda Y; Takahashi S; Kimura J; Cho Y M; Imaida K; Shirai S; Shirai T
Anophthalmia in litters of female rats treated with the food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Toxicologic pathology 1999;27(6):628-31.
1999: Hirose M; Fukushima S; Imaida K; Ito N; Shirai T
Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis.
Anticancer research 1999;19(5A):3665-70.
1999: Hirose M; Takahashi S; Ogawa K; Futakuchi M; Shirai T
Phenolics: blocking agents for heterocyclic amine-induced carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(9-10):985-92.
1999: Shirai T; Cui L; Takahashi S; Futakuchi M; Asamoto M; Kato K; Ito N
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) in the rat prostate and induction of invasive carcinomas by subsequent treatment with testosterone propionate.
Cancer letters 1999;143(2):217-21.
1999: Hirose M; Takahashi S; Ogawa K; Futakuchi M; Shirai T; Shibutani M; Uneyama C; Toyoda K; Iwata H
Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats.
Cancer letters 1999;143(2):173-8.
1999: Sano M; Hagiwara A; Tamano S; Hasegawa R; Imaida K; Ito N; Shirai T
Dose-dependent induction of carcinomas and glutathione S-transferase placental form negative eosinophilic foci in the rat liver by di(2-ethylhexyl)phthalate after diethylnitrosamine initiation.
The Journal of toxicological sciences 1999;24(3):177-86.
1999: Shirai T
Commentary: oncosis and apoptosis: two faces of necrosis in a new proposal to clear up the confusion regarding cell death.
Toxicologic pathology 1999;27(4):495-6.
1999: Hirose M; Hakoi K; Takahashi S; Hoshiya T; Akagi K; Lin C; Saito K; Kaneko H; Shirai T
Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats.
Toxicologic pathology 1999;27(4):448-55.
1999: Ogawa K; Tsuda H; Shirai T; Ogiso T; Wakabayashi K; Dalgard D W; Thorgeirsson U P; Thorgeirsson S S; Adamson R H; Sugimura T
Lack of carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in cynomolgus monkeys.
Japanese journal of cancer research : Gann 1999;90(6):622-8.
1999: Hagiwara A; Boonyaphiphat P; Tanaka H; Kawabe M; Tamano S; Kaneko H; Matsui M; Hirose M; Ito N; Shirai T
Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344 rats.
Japanese journal of cancer research : Gann 1999;90(4):399-405.
1999: Iwasaki S; Kato K; Mori T; Takahashi S; Futakuchi M; Shirai T
Development of androgen-independent carcinomas from androgen-dependent preneoplastic lesions in the male accessory sex organs of rats treated with 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.
Japanese journal of cancer research : Gann 1999;90(1):23-30.
1999: Shirai T; Hirose M; Ito N
Medium-term bioassays in rats for rapid detection of the carcinogenic potential of chemicals.
IARC scientific publications 1999;(146):251-72.
1999: Hagiwara A; Murai T; Yoshino H; Goshima H; Mori S; Takashima A; Shirai T; Fukushima S
Hepatocarcinogenic activity of N-butyl-N-(4-hydroxybutyl)nitrosamine in rats is not modified by sodium L-ascorbate.
Teratogenesis, carcinogenesis, and mutagenesis 1999;19(1):33-42.
1998: Shirai T; Takahashi S; Cui L; Yamada Y; Tada M; Kadlubar F F; Ito N
Use of polyclonal antibodies against carcinogen-DNA adducts in analysis of carcinogenesis.
Toxicology letters 1998;102-103():441-6.
1998: Ito N; Imaida K; Hirose M; Shirai T
Medium-term bioassays for carcinogenicity of chemical mixtures.
Environmental health perspectives 1998;106 Suppl 6():1331-6.
1998: Imaida K; Taki M; Watanabe S; Kamimura Y; Ito T; Yamaguchi T; Ito N; Shirai T
The 1.5 GHz electromagnetic near-field used for cellular phones does not promote rat liver carcinogenesis in a medium-term liver bioassay.
Japanese journal of cancer research : Gann 1998;89(10):995-1002.
1998: Takahashi S; Tamano S; Hirose M; Kimoto N; Ikeda Y; Sakakibara M; Tada M; Kadlubar F F; Ito N; Shirai T
Immunohistochemical demonstration of carcinogen-DNA adducts in tissues of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): detection in paraffin-embedded sections and tissue distribution.
Cancer research 1998;58(19):4307-13.
1998: Yamada Y; Tozawa K; Cui L; Takahashi S; Shirai T; Kohri K
Characteristics of nonneoplastic human prostate tissue transplanted into nude mice.
The Prostate 1998;37(2):109-15.
1998: Zhang R; Takahashi S; Orita S; Yoshida A; Maruyama H; Shirai T; Ohta N
p53 gene mutations in rectal cancer associated with schistosomiasis japonica in Chinese patients.
Cancer letters 1998;131(2):215-21.
1998: Hirose M; Yamaguchi T; Kimoto N; Ogawa K; Futakuchi M; Sano M; Shirai T
Strong promoting activity of phenylethyl isothiocyanate and benzyl isothiocyanate on urinary bladder carcinogenesis in F344 male rats.
International journal of cancer. Journal international du cancer 1998;77(5):773-7.
1998: Ito N; Imaida K; Tamano S; Hagiwara A; Shirai T
Medium-term bioassays as alternative carcinogenicity test.
The Journal of toxicological sciences 1998;23 Suppl 2():103-6.
1998: Takahashi S; Kimoto N; Orita S; Cui L; Sakakibara M; Shirai T
Relationship between CD44 expression and differentiation of human prostate adenocarcinomas.
Cancer letters 1998;129(1):97-102.
1998: Hirose M; Ito T; Takahashi S; Ozaki M; Ogiso T; Nihro Y; Miki T; Shirai T
Prevention by synthetic phenolic antioxidants of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)- or activated MeIQx-induced mutagenesis and MeIQx-induced rat hepatocarcinogenesis, and role of antioxidant activity in the prevention of carcinogenesis.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(3):233-41.
1998: Ogawa K; Futakuchi M; Hirose M; Boonyaphiphat P; Mizoguchi Y; Miki T; Shirai T
Stage and organ dependent effects of 1-O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, n-heptadecane-8-10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model.
International journal of cancer. Journal international du cancer 1998;76(6):851-6.
1998: Mizoguchi Y; Hirose M; Yamaguchi T; Boonyaphiphat P; Miki T; Shirai T
Dose dependence of 1-O-hexyl-2,3,5-trimethylhydroquinone promotion of forestomach carcinogenesis in rats pretreated with N-ethylnitrosourethane.
Japanese journal of cancer research : Gann 1998;89(5):475-80.
1998: Futakuchi M; Hirose M; Miki T; Tanaka H; Ozaki M; Shirai T
Inhibition of DMBA-initiated rat mammary tumour development by 1-O-hexyl-2,3,5-trimethylhydroquinone, phenylethyl isothiocyanate, and novel synthetic ascorbic acid derivatives.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(2):153-9.
1998: Tamano S; Hirose M; Tanaka H; Hagiwara A; Shirai T
Variation in susceptibility to the induction of forestomach tumours by butylated hydroxyanisole among rats of different strains.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(4):299-304.
1998: Kato T; Hirose M; Takahashi S; Hasegawa R; Kohno T; Nishibe S; Kato K; Shirai T
Effects of the lignan, arctiin, on 17-beta ethinyl estradiol promotion of preneoplastic liver cell foci development in rats.
Anticancer research 1998;18(2A):1053-7.
1998: Takahashi S; Hirose M; Tamano S; Ozaki M; Orita S; Ito T; Takeuchi M; Ochi H; Fukada S; Kasai H; Shirai T
Immunohistochemical detection of 8-hydroxy-2'-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment.
Toxicologic pathology 1998;26(2):247-52.
1998: Hirose M; Futakuchi M; Tanaka H; Orita S I; Ito T; Miki T; Shirai T
Prevention by antioxidants of heterocyclic amine-induced carcinogenesis in a rat medium-term liver bioassay: results of extended and combination treatment experiments.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1998;7(1):61-7.
1998: Ogawa K; Iwasaki S; Esumi H; Fukushima S; Shirai T
Modification by 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) of 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced rat pancreatic and intestinal tumorigenesis.
Cancer letters 1998;124(1):31-7.
1998: Imaida K; Taki M; Yamaguchi T; Ito T; Watanabe S; Wake K; Aimoto A; Kamimura Y; Ito N; Shirai T
Lack of promoting effects of the electromagnetic near-field used for cellular phones (929.2 MHz) on rat liver carcinogenesis in a medium-term liver bioassay.
Carcinogenesis 1998;19(2):311-4.
1998: Hasegawa R; Futakuchi M; Mizoguchi Y; Yamaguchi T; Shirai T; Ito N; Lijinsky W
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Cancer letters 1998;123(2):185-91.
1998: Wada S; Hirose M; Shichino Y; Ozaki K; Hoshiya T; Kato K; Shirai T
Effects of catechol, sodium chloride and ethanol either alone or in combination on gastric carcinogenesis in rats pretreated with N-methyl-N'-nitro-N-nitrosoguanidine.
Cancer letters 1998;123(2):127-34.
1998: Hirose M; Takesada Y; Tanaka H; Tamano S; Kato T; Shirai T
Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model.
Carcinogenesis 1998;19(1):207-12.
1998: Cui L; Mori T; Takahashi S; Imaida K; Akagi K; Yada H; Yaono M; Shirai T
Slight promotion effects of intermittent administration of testosterone propionate and/or diethylstilbestrol on 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.
Cancer letters 1998;122(1-2):195-9.
1997: Hirose M; Shirai T; Lee M S; Wang C Y; King C M
Carcinogenecity of the N-acyl derivatives of N-hydroxy-trans-4-aminostilbene in CD rats.
Chemico-biological interactions 1997;106(2):123-32.
1997: Shirai T
A medium-term rat liver bioassay as a rapid in vivo test for carcinogenic potential: a historical review of model development and summary of results from 291 tests.
Toxicologic pathology 1997;25(5):453-60.
1997: Tanaka H; Hirose M; Kawabe M; Sano M; Takesada Y; Hagiwara A; Shirai T
Post-initiation inhibitory effects of green tea catechins on 7,12-dimethylbenz[a]anthracene-induced mammary gland carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1997;116(1):47-52.
1997: Ito N; Hasegawa R; Imaida K; Tamano S; Hagiwara A; Hirose M; Shirai T
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
Mutation research 1997;376(1-2):107-14.
1997: Ozaki M; Shibata M A; Takahashi S; Orita S I; Kawabe M; Shirai T
Lack of involvement of p53 gene mutations in N-methyl-N-nitrosourea-induced bladder tumor progression in N-butyl-N-(4-hydroxybutyl)nitrosamine-treated rats and no suppression by indomethacin.
Cancer letters 1997;115(2):249-55.
1997: Imaida K; Hasegawa R; Kato T; Futakuchi M; Takahashi S; Ogawa K; Asamoto M; Yamamoto T; Suzuki K; Inagaki T; Shinagawa N; Shirai T
Clinicopathological analysis on cancers of autopsy cases in a geriatric hospital.
Pathology international 1997;47(5):293-300.
1997: Kawabe M; Shibata M A; Sano M; Takesada Y; Tamano S; Ito N; Shirai T
Decrease of prostaglandin E2 and 5-bromo-2'-deoxyuridine labeling but not prostate tumor development by indomethacin treatment of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.
Japanese journal of cancer research : Gann 1997;88(4):350-5.
1997: Miyata E; Kawabe M; Sano M; Takesada Y; Takahashi S; Shirai T
Effects of tamoxifen, an antiestrogen, on rat prostate carcinogenesis by 3,2'-dimethyl-4-aminobiphenyl and testosterone do not support an estrogen role in testosterone promotion.
The Prostate 1997;31(1):9-13.
1997: Takaba K; Hirose M; Yoshida Y; Kimura J; Ito N; Shirai T
Effects of n-tritriacontane-16,18-dione, curcumin, chlorphyllin, dihydroguaiaretic acid, tannic acid and phytic acid on the initiation stage in a rat multi-organ carcinogenesis model.
Cancer letters 1997;113(1-2):39-46.
1997: Hirose M; Mizoguchi Y; Yaono M; Tanaka H; Yamaguchi T; Shirai T
Effects of green tea catechins on the progression or late promotion stage of mammary gland carcinogenesis in female Sprague-Dawley rats pretreated with 7,12-dimethylbenz(a)anthracene.
Cancer letters 1997;112(2):141-7.
1997: Masui T; Nakanishi H; Inada K; Imai T; Mizoguchi Y; Yada H; Futakuchi M; Shirai T; Tatematsu M
Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes.
Cancer letters 1997;112(1):33-45.
1997: Saeki K; Kadoi M; Kawazoe Y; Futakuchi M; Tiwawech D; Shirai T
Modification of the carcinogenic potency of quinoline, a hepatocarcinogen, by fluorine atom substitution: evaluation of carcinogenicity by a medium-term assay.
Biological & pharmaceutical bulletin 1997;20(1):40-3.
1997: Shirai T; Sano M; Tamano S; Takahashi S; Hirose M; Futakuchi M; Hasegawa R; Imaida K; Matsumoto K; Wakabayashi K; Sugimura T; Ito N
The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.
Cancer research 1997;57(2):195-8.
1996: Nakanishi H; Takeuchi S; Kato K; Shimizu S; Kobayashi K; Tatematsu M; Shirai T
Establishment and characterization of three androgen-independent, metastatic carcinoma cell lines from 3,2'-dimethyl-4-aminobiphenyl-induced prostatic tumors in F344 rats.
Japanese journal of cancer research : Gann 1996;87(12):1218-26.
1996: Hagiwara A; Matsuda T; Tamano S; Kitano M; Imaoka S; Funae Y; Takesada Y; Shirai T; Fukushima S
Dose-related increases in quantitative values for altered hepatocytic foci and cytochrome P-450 levels in the livers of rats exposed to phenobarbital in a medium-term bioassay.
Cancer letters 1996;110(1-2):155-62.
1996: Hasegawa R; Kato T; Hirose M; Takahashi S; Shirai T; Ito N
Enhancement of hepatocarcinogenesis by combined administration of food-derived heterocyclic amines at low doses in the rat.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(11-12):1097-101.
1996: Ito N; Hagiwara A; Tamano S; Futacuchi M; Imaida K; Shirai T
Effects of pesticide mixtures at the acceptable daily intake levels on rat carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(11-12):1091-6.
1996: Hasegawa R; Yoshimura I; Imaida K; Ito N; Shirai T
Analysis of synergism in hepatocarcinogenesis based on preneoplastic foci induction by 10 heterocyclic amines in the rat.
Japanese journal of cancer research : Gann 1996;87(11):1125-33.
1996: Imaida K; Hagiwara A; Yada H; Masui T; Hasegawa R; Hirose M; Sugimura T; Ito N; Shirai T
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
Japanese journal of cancer research : Gann 1996;87(11):1116-20.
1996: Futakuchi M; Lijinsky W; Hasegawa R; Hirose M; Ito N; Shirai T
Effects of low dose mixtures of four N-nitroso compounds on hepatic foci development in the rat.
Cancer letters 1996;106(2):263-9.
1996: Thamavit W; Tiwawech D; Moore M A; Ito N; Shirai T
Equivocal evidence of complete carcinogenicity after repeated infection of Syrian hamsters with Opisthorchis viverrini.
Toxicologic pathology 1996;24(4):493-7.
1996: Kimura J; Takahashi S; Ogiso T; Yoshida Y; Akagi K; Hasegawa R; Kurata M; Hirose M; Shirai T
Lack of chemoprevention effects of the monoterpene d-limonene in a rat multi-organ carcinogenesis model.
Japanese journal of cancer research : Gann 1996;87(6):589-94.
1996: Mori T; Cui L; Kato K; Takahashi S; Imaida K; Iwasaki S; Ito N; Shirai T
Direct effects of testosterone, dihydrotestosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in castrated F344 rats.
Japanese journal of cancer research : Gann 1996;87(6):570-4.
1996: Futakuchi M; Hasegawa R; Yamamoto A; Cui L; Ogiso T; Ito N; Shirai T
Low susceptibility of the spontaneously hypertensive rat (SHR) to quinoline-induction of hepatic hemangioendothelial sarcomas.
Cancer letters 1996;104(1):37-41.
1996: Takahashi S; Imaida K; Shirai T; Wakabayashi K; Nagao M; Sugimura T; Ito N
Chronic administration of the mutagenic heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces cardiac damage with characteristic mitochondrial changes in Fischer rats.
Toxicologic pathology 1996;24(3):273-7.
1996: Sano M; Miyata E; Tamano S; Hagiwara A; Ito N; Shirai T
Lack of carcinogenicity of tamarind seed polysaccharide in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(5):463-7.
1996: Kawabe M; Takesada Y; Tamano S; Hagiwara A; Ito N; Shirai T
Subchronic toxicity study of L-isoleucine in F344 rats.
Journal of toxicology and environmental health 1996;47(5):499-508.
1996: Tanaka H; Hasegawa R; Takesada Y; Ogiso T; Hirose M; Shirai T
Effects of carbamate insecticides in a rat medium-term bioassay for hepatocarcinogens.
Journal of toxicology and environmental health 1996;47(5):493-8.
1996: Kimura J; Hasegawa R; Yaono M; Kato T; Wakabayashi K; Sugimura T; Ito N; Shirai T
Inhibitory potential of pregnancy and lactation on mammary carcinogenesis induced by a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in Sprague-Dawley rats.
Cancer letters 1996;101(1):73-8.
1996: Ito N; Hasegawa R; Imaida K; Hirose M; Shirai T
Medium-term liver and multi-organ carcinogenesis bioassays for carcinogens and chemopreventive agents.
Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996;48(2-3):113-9.
1996: Ogawa K; Imaida K; Masui T; Kawabe M; Hasegawa R; Kato K; Ito N; Shirai T
Chemically induced lung and forestomach neoplasias in transgenic mice carry mutant forms of the human c-Ha-ras transgene.
Carcinogenesis 1996;17(2):341-5.
1996: Kato T; Hasegawa R; Nakae D; Hirose M; Yaono M; Cui L; Kobayashi Y; Konishi Y; Ito N; Shirai T
Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.
Japanese journal of cancer research : Gann 1996;87(2):127-33.
1996: Cui L; Hasegawa R; Ogawa K; Yamada Y; Takahashi S; Shirai T
Histopathological analysis of invasive bladder carcinomas induced by 3,2'-dimethyl-4-aminobiphenyl in hamsters.
Japanese journal of cancer research : Gann 1996;87(1):37-43.
1996: Yaono M; Hasegawa R; Kato K; Kimura J; Lin C; Tada M; Shirai T
Immunohistochemical demonstration of 3,2'-dimethyl-4-aminobiphenyl DNA adduct formation in various organs of Syrian golden hamsters.
Cancer letters 1996;98(2):145-9.
1996: Hagiwara A; Kokubo Y; Takesada Y; Tanaka H; Tamano S; Hirose M; Shirai T; Ito N
Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats.
Teratogenesis, carcinogenesis, and mutagenesis 1996;16(6):317-25.
1995: Ito N; Hagiwara A; Tamano S; Hasegawa R; Imaida K; Hirose M; Shirai T
Lack of carcinogenicity of pesticide mixtures administered in the diet at acceptable daily intake (ADI) dose levels in rats.
Toxicology letters 1995;82-83():513-20.
1995: Ito N; Hasegawa R; Imaida K; Hirose M; Asamoto M; Shirai T
Concepts in multistage carcinogenesis.
Critical reviews in oncology/hematology 1995;21(1-3):105-133.
1995: Shibata M; Hasegawa R; Imaida K; Hagiwara A; Ogawa K; Hirose M; Ito N; Shirai T
Chemoprevention by dehydroepiandrosterone and indomethacin in a rat multiorgan carcinogenesis model.
Cancer research 1995;55(21):4870-4.
1995: Ogawa K; Shichino Y; Tatematsu M; Furihata C; Asamoto M; Nagase S; Shirai T; Ito N
Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats.
Cancer letters 1995;96(2):219-24.
1995: Hasegawa R; Hirose M; Kato T; Hagiwara A; Boonyaphiphat P; Nagao M; Ito N; Shirai T
Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats.
Carcinogenesis 1995;16(9):2243-6.
1995: Hirose M; Iwata S; Ito E; Nihro Y; Takahashi S; Mizoguchi Y; Miki T; Satoh T; Ito N; Shirai T
Strong anti-mutagenic activity of the novel lipophilic antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone against heterocyclic amine-induced mutagenesis in the Ames assay and its effect on metabolic activation of 2-amino-6-methyldipyrido[1,2-a:3',2'-d] imidazole (Glu-p-1).
Carcinogenesis 1995;16(9):2227-32.
1995: Yaono M; Hasegawa R; Mizoguchi Y; Futakuchi M; Nakamura T; Ito N; Shirai T
Hepatocyte growth factor enhancement of preneoplastic hepatic foci development in rats treated with diethylnitrosamine and N-ethyl-N-hydroxyethylnitrosamine.
Japanese journal of cancer research : Gann 1995;86(8):718-23.
1995: Akagi K; Hirose M; Hoshiya T; Mizoguchi Y; Ito N; Shirai T
Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model.
Cancer letters 1995;94(1):113-21.
1995: Shirai T; Tamano S; Sano M; Imaida K; Hagiwara A; Futakuchi M; Takahashi S; Hirose M
Site-specific effects of testosterone propionate on the prostate of rat pretreated with 3,2'-dimethyl-4-aminobiphenyl: dose-dependent induction of invasive carcinomas.
Japanese journal of cancer research : Gann 1995;86(7):645-8.
1995: Shirai T; Fradet Y; Huland H; Bollack C; Droller M; Janknegt R; Jones P; Kagawa S
The etiology of bladder cancer--are there any new clues or predictors of behavior?
International journal of urology : official journal of the Japanese Urological Association 1995;2 Suppl 2():64-75.
1995: Masui T; Shirai T; Imaida K; Hirose M; Futakuchi M; Tatematsu M; Ito N
Ki-ras mutations with frequent normal allele loss versus absence of p53 mutations in rat prostate and seminal vesicle carcinomas induced with 3,2'-dimethyl-4-aminobiphenyl.
Molecular carcinogenesis 1995;13(1):21-6.
1995: Shibata M A; Tanaka H; Kawabe M; Sano M; Hagiwara A; Shirai T
Lack of carcinogenicity of monosodium L-glutamate in Fischer 344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(5):383-91.
1995: Shirai T; Shibata M; Takahashi S; Tagawa Y; Imaida K; Hirose M
Differences in cell proliferation and apoptosis between reversible and irreversible mucosal lesions associated with uracil-induced urolithiasis in N-butyl-N-(4-hydroxybutyl)nitrosamine-pretreated.
Carcinogenesis 1995;16(3):501-5.
1995: Tanaka H; Hirose M; Hagiwara A; Imaida K; Shirai T; Ito N
Rat strain differences in catechol carcinogenicity to the stomach.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):93-8.
1995: Ito N; Hasegawa R; Imaida K; Kurata Y; Hagiwara A; Shirai T
Effect of ingestion of 20 pesticides in combination at acceptable daily intake levels on rat liver carcinogenesis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(2):159-63.
1995: Shibata M A; Sano M; Hagiwara A; Hasegawa R; Shirai T
Modification by analgesics of lesion development in the urinary tract and various other organs of rats pretreated with dihydroxy-di-N-propylnitrosamine and uracil.
Japanese journal of cancer research : Gann 1995;86(2):160-7.
1995: Hasegawa R; Ogiso T; Imaida K; Shirai T; Ito N
Analysis of the potential carcinogenicity of coffee and its related compounds in a medium-term liver bioassay of rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(1):15-20.
1995: Kato T; Ogiso T; Kato K; Sano M; Hasegawa R; Shirai T; Ito N
Lack of promoting activity of four pesticides on induction of preneoplastic liver cell foci in rats.
Teratogenesis, carcinogenesis, and mutagenesis 1995;15(5):251-7.
1995: Shirai T; Tamano S; Sano M; Masui T; Hasegawa R; Ito N
Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.
Princess Takamatsu symposia 1995;23():232-9.
1994: Shibata M A; Shirai T; Ogawa K; Takahashi S; Wild C P; Montesano R; Tsuda H; Ito N
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Carcinogenesis 1994;15(12):2965-8.
1994: Hasegawa R; Tanaka H; Tamano S; Shirai T; Nagao M; Sugimura T; Ito N
Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocyclic amines in a medium-term multi-organ bioassay.
Carcinogenesis 1994;15(11):2567-73.
1994: Masui T; Don I; Takada N; Ogawa K; Shirai T; Fukushima S
p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis 1994;15(10):2379-81.
1994: Asamoto M; Takahashi S; Imaida K; Shirai T; Fukushima S
Increased gap junctional intercellular communication capacity and connexin 43 and 26 expression in rat bladder carcinogenesis.
Carcinogenesis 1994;15(10):2163-6.
1994: Itoh M; Pairojkul C; Thamawit W; Sithithaworn P; Tiwawech D; Uttaravicien T; Shirai T; Ito N
Association of antibodies to Opisthorchis viverrini with hepatobiliary disease in northeastern Thailand.
The American journal of tropical medicine and hygiene 1994;51(4):424-9.
1994: Shirai T; Tada M; Kojima M; Hasegawa R; Masui T; Ito N
DNA adducts in target and nontarget tissues of 3,2'-dimethyl-4-aminobiphenyl in rats.
Environmental health perspectives 1994;102 Suppl 6():167-72.
1994: Shirai T; Sano M; Imaida K; Takahashi S; Mori T; Ito N
Duration dependent induction of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2'-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration.
Cancer letters 1994;83(1-2):111-6.
1994: Thamavit W; Pairojkul C; Tiwawech D; Shirai T; Ito N
Strong promoting effect of Opisthorchis viverrini infection on dimethylnitrosamine-initiated hamster liver.
Cancer letters 1994;78(1-3):121-5.
1994: Shirai T; Imaida K; Masui T; Iwasaki S; Mori T; Kato T; Ito N
Effects of testosterone, dihydrotestosterone and estrogen on 3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.
International journal of cancer. Journal international du cancer 1994;57(2):224-8.
1994: Cui L; Hasegawa R; Zajdela F; Puapairoj P; Shirai T; Ito N
Lack of promoting activity of 7-methoxy-2-nitro-naphtho-[2,1-b]furan (R7000) in a medium-term rat liver bioassay.
Cancer letters 1994;76(2-3):161-6.
1994: Ito N; Hasegawa R; Imaida K; Takahashi S; Shirai T
Medium-term rat liver bioassay for rapid detection of carcinogens and modifiers of hepatocarcinogenesis.
Drug metabolism reviews 1994;26(1-2):431-42.
1994: Thamavit W; Pairojkul C; Tiwawech D; Shirai T; Ito N
Lack of promoting effect of proline on bile duct cancer development in dimethylnitrosamine-initiated hamster livers.
Teratogenesis, carcinogenesis, and mutagenesis 1994;14(4):169-74.
1994: Shibata M A; Shirai T; Takahashi S; Takesada Y; Iwata H; Okumura M; Fukushima S
Progressive growth of rat bladder carcinomas after exposure to prolonged uracil-induced urolithiasis.
Teratogenesis, carcinogenesis, and mutagenesis 1994;14(4):157-68.
1993: Kato T; Imaida K; Ogawa K; Hesegawa R; Shirai T; Tatematsu M
Three-dimensional analysis of glutathione S-transferase placental form-positive lesion development in early stages of rat hepatocarcinogenesis.
Japanese journal of cancer research : Gann 1993;84(12):1252-7.
1993: Hasegawa R; Sano M; Tamano S; Imaida K; Shirai T; Nagao M; Sugimura T; Ito N
Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.
Carcinogenesis 1993;14(12):2553-7.
1993: Shibata M A; Hasegawa R; Shirai T; Takesada Y; Fukushima S
Chemoprevention by indomethacin of tumor promotion in a rat urinary bladder carcinogenesis model.
International journal of cancer. Journal international du cancer 1993;55(6):1011-7.
1993: Thamavit W; Pairojkul C; Tiwawech D; Itoh M; Shirai T; Ito N
Promotion of cholangiocarcinogenesis in the hamster liver by bile duct ligation after dimethylnitrosamine initiation.
Carcinogenesis 1993;14(11):2415-7.
1993: Shirai T; Iwasaki S; Masui T; Mori T; Kato T; Ito N
Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl.
Japanese journal of cancer research : Gann 1993;84(10):1023-30.
1993: Shibata M A; Sano M; Shirai T; Imaida K; Fukushima S
Epithelia hyperplasia in the renal papilla and pelvis but not the urinary bladder of male F344 rats associated with dietary sodium phosphates after uracil exposure.
Toxicology and applied pharmacology 1993;121(2):303-12.
1993: Hasegawa R; Cabral R; Hoshiya T; Hakoi K; Ogiso T; Boonyaphiphat P; Shirai T; Ito N
Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats.
International journal of cancer. Journal international du cancer 1993;54(3):489-93.
1993: Toyoda K; Imaida K; Shirai T; Imazawa T; Takahashi M
Relationship between bisacodyl-induced urolithiasis and rat urinary bladder tumorigenesis.
Journal of toxicology and environmental health 1993;39(1):59-78.
1993: Tamano S; Tanaka H; Kawabe M; Asakawa E; Sano M; Shioya S; Shirai T; Fukushima S
No enhancing effects of calcium/magnesium salts of L-glutamate and L-ascorbate on tumor development in a rat medium-term multiorgan carcinogenesis bioassay.
Journal of toxicology and environmental health 1993;39(1):43-58.
1993: Shibata M A; Shirai T; Asakawa E; Hirose M; Fukushima S
Inhibition by dehydroepiandrosterone of butylated hydroxyanisole (BHA) promotion of rat-bladder carcinogenesis and enhancement of BHA-induced forestomach hyperplasia.
International journal of cancer. Journal international du cancer 1993;53(5):819-23.
1993: Thamavit W; Moore M A; Sirisinha S; Shirai T; Ito N
Time-dependent modulation of liver lesion development in Opisthorchis-infected Syrian hamster by an antihelminthic drug, praziquantel.
Japanese journal of cancer research : Gann 1993;84(2):135-8.
1993: Shirai T; Imaida K; Iwasaki S; Mori T; Tada M; Ito N
Sequential observation of rat prostate lesion development induced by 3,2'-dimethyl-4-aminobiphenyl and testosterone.
Japanese journal of cancer research : Gann 1993;84(1):20-5.
1993: Hirose M; Shirai T; Takahashi S; Ogawa K; Ito N
Organ-specific modification of carcinogenesis by antioxidants in rats.
Basic life sciences 1993;61():181-8.
1992: Hasegawa R; Ogawa K; Takaba K; Shirai T; Ito N
3,2'-Dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters.
Japanese journal of cancer research : Gann 1992;83(12):1286-92.
1992: Ito N; Hasegawa R; Imaida K; Masui T; Takahashi S; Shirai T
Pathological markers for non-genotoxic agent-associated carcinogenesis.
Toxicology letters 1992;64-65 Spec No():613-20.
1992: Hasegawa R; Takahashi S; Shirai T; Iwasaki S; Kim D J; Ochiai M; Nagao M; Sugimura T; Ito N
Dose-dependent formation of preneoplastic foci and DNA adducts in rat liver with 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Carcinogenesis 1992;13(8):1427-31.
1992: Shibata M; Tamano S; Shirai T; Kawabe M; Fukushima S
Inorganic alkalizers and acidifiers under conditions of high urinary Na+ or K+ on cell proliferation and two-stage carcinogenesis in the rat bladder.
Japanese journal of cancer research : Gann 1992;83(8):821-9.
1992: Hagiwara A; Boonyaphiphat P; Kawabe M; Naito H; Shirai T; Ito N
Lack of carcinogenicity of tragacanth gum in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(8):673-9.
1992: Ogawa K; Hoshiya T; Kato T; Shirai T; Tatematsu M
Reversibility of carcinogen-induced rat forestomach basal cell hyperplasia is due to squamous cell differentiation.
Japanese journal of cancer research : Gann 1992;83(7):699-704.
1992: Shirai T; Iwasaki S; Naito H; Masui T; Kato T; Imaida K
Dose dependence of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis.
Japanese journal of cancer research : Gann 1992;83(7):695-8.
1992: Kagawa M; Yamamoto A; Ogawa K; Shirai T; Fukushima S
Uracil-induced urolithiasis in the urinary bladder of rats is irritation-dependent.
Toxicology letters 1992;61(1):21-6.
1992: Okumura M; Hasegawa R; Shirai T; Ito M; Yamada S; Fukushima S
Relationship between calculus formation and carcinogenesis in the urinary bladder of rats administered the non-genotoxic agents thymine or melamine.
Carcinogenesis 1992;13(6):1043-5.
1992: Hasegawa R; Tiwawech D; Hirose M; Takaba K; Hoshiya T; Shirai T; Ito N
Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
Japanese journal of cancer research : Gann 1992;83(5):431-7.
1992: Fukushima S; Tanaka H; Asakawa E; Kagawa M; Yamamoto A; Shirai T
Carcinogenicity of uracil, a nongenotoxic chemical, in rats and mice and its rationale.
Cancer research 1992;52(7):1675-80.
1992: Tagawa Y; Ozaki K; Takahashi S; Ogawa K; Shirai T
Lack of effects of post-initiation cholesterol on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis.
The Prostate 1992;20(3):179-85.
1992: Tamano S; Shirai T; Kawabe M; Ni-I H; Mori Y; Okada M; Fukushima S
Low susceptibility of nude mice to induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine.
Toxicologic pathology 1992;20(2):205-11.
1992: Ito N; Shirai T; Hasegawa R
Medium-term bioassays for carcinogens.
IARC scientific publications 1992;(116):353-88.
1992: Hakoi K; Cabral R; Hoshiya T; Hasegawa R; Shirai T; Ito N
Analysis of carcinogenic activity of some pesticides in a medium-term liver bioassay in the rat.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(6):269-76.
1992: Shirai T; Yamamoto A; Imaida K; Tamano S; Mori T; Hasegawa R
Lack of synergism among DMAB, BOP, and MNU in induction of carcinomas of the rat ventral prostate.
Teratogenesis, carcinogenesis, and mutagenesis 1992;12(2):71-7.
1991: Hasegawa R; Shirai T; Hakoi K; Takaba K; Iwasaki S; Hoshiya T; Ito N; Nagao M; Sugimura T
Synergistic enhancement of glutathione S-transferase placental form-positive hepatic foci development in diethylnitrosamine-treated rats by combined administration of five heterocyclic amines at low doses.
Japanese journal of cancer research : Gann 1991;82(12):1378-84.
1991: Shirai T; Yamamoto A; Iwasaki S; Tamano S; Masui T
Induction of invasive carcinomas of the seminal vesicles and coagulating glands of F344 rats by administration of N-methylnitrosourea or N-nitrosobis(2-oxopropyl)amine and followed by testosterone propionate with or without high-fat diet.
Carcinogenesis 1991;12(11):2169-73.
1991: de Camargo J L; Shirai T; Kato T; Asamoto M; Fukushima S
Summation effects of uracil and other promoters on epithelial lesion development in the F344 rat urinary bladder initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Japanese journal of cancer research : Gann 1991;82(11):1220-5.
1991: Shibata M A; Hirose M; Tanaka H; Asakawa E; Shirai T; Ito N
Induction of renal cell tumors in rats and mice, and enhancement of hepatocellular tumor development in mice after long-term hydroquinone treatment.
Japanese journal of cancer research : Gann 1991;82(11):1211-9.
1991: Hagiwara A; Hirose M; Takahashi S; Ogawa K; Shirai T; Ito N
Forestomach and kidney carcinogenicity of caffeic acid in F344 rats and C57BL/6N x C3H/HeN F1 mice.
Cancer research 1991;51(20):5655-60.
1991: Shirai T; Joong K D; Hakoi K; Thamavit W; Pairojkul C; Hoshiya T; Hasegawa R; Ito N
Promotion of rat hepatocarcinogenesis by praziquantel.
Japanese journal of cancer research : Gann 1991;82(10):1085-8.
1991: Hagiwara A; Tanaka H; Tiwawech D; Shirai T; Ito N
Oral toxicity study of tragacanth gum in B6C3F1 mice: development of squamous-cell hyperplasia in the forestomach and its reversibility.
Journal of toxicology and environmental health 1991;34(2):207-18.
1991: Shibata M A; Hasegawa R; Sano M; Shirai T; Fukushima S
Timing effects of uracil-induced urolithiasis on amplification of second-stage promotion in rat bladder carcinogenesis.
Japanese journal of cancer research : Gann 1991;82(10):1077-84.
1991: Hirose M; Ozaki K; Takaba K; Fukushima S; Shirai T; Ito N
Modifying effects of the naturally occurring antioxidants gamma-oryzanol, phytic acid, tannic acid and n-tritriacontane-16, 18-dione in a rat wide-spectrum organ carcinogenesis model.
Carcinogenesis 1991;12(10):1917-21.
1991: Hasegawa R; Shirai T; Hakoi K; Wada S; Yamaguchi K; Takayama S
Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N'-diethylthiourea and 4,4'-thiodianiline in male F344 rats.
Carcinogenesis 1991;12(8):1515-8.
1991: Shirai T; Fukushima S; Kawabe M; Shibata M; Iwasaki S; Tada M; Ito N
Selective induction of rat urinary bladder tumors by simultaneous administration of 3,2'-dimethyl-4-aminobiphenyl (DMAB) and butylated hydroxyanisole or butylated hydroxytoluene is associated with increased DMAB-DNA adduct formation.
Carcinogenesis 1991;12(7):1335-9.
1991: Nakamura A; Shirai T; Takahashi S; Ogawa K; Hirose M; Ito N
Lack of modification by naturally occurring antioxidants of 3,2'-dimethyl-4-aminobiphenyl-initiated rat prostate carcinogenesis.
Cancer letters 1991;58(3):241-6.
1991: Okumura M; Shirai T; Asamoto M; Ogiso T; Fukushima S
Lack of synergism in rat urinary tract carcinogenesis between prior uracil treatment and N-butyl-N-(4-hydroxybutyl)-nitrosamine administration.
Cancer letters 1991;58(1-2):81-5.
1991: Tamano S; Hagiwara A; Suzuki E; Okada M; Shirai T; Fukushima S
Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice.
Japanese journal of cancer research : Gann 1991;82(6):650-6.
1991: Ito N; Hasegawa R; Shirai T; Fukushima S; Hakoi K; Takaba K; Iwasaki S; Wakabayashi K; Nagao M; Sugimura T
Enhancement of GST-P positive liver cell foci development by combined treatment of rats with five heterocyclic amines at low doses.
Carcinogenesis 1991;12(5):767-72.
1991: Hasegawa R; Takahashi S; Imaida K; Yamaguchi S; Shirai T; Ito N
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Japanese journal of cancer research : Gann 1991;82(3):293-7.
1991: Shirai T; Tamano S; Kato T; Iwasaki S; Takahashi S; Ito N
Induction of invasive carcinomas in the accessory sex organs other than the ventral prostate of rats given 3,2'-dimethyl-4-aminobiphenyl and testosterone propionate.
Cancer research 1991;51(4):1264-9.
1991: Okumura M; Shirai T; Tamano S; Ito M; Yamada S; Fukushima S
Uracil-induced calculi and carcinogenesis in the urinary bladder of rats treated simultaneously with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis 1991;12(1):35-41.
1991: Ito N; Shirai T; Fukushima S
Medium-term bioassay for carcinogens using multiorgan models.
Progress in experimental tumor research. Fortschritte der experimentellen Tumorforschung. Progrès de la recherche expérimentale des tumeurs 1991;33():41-57.
1991: Ito N; Shirai T; Masui T; Ogawa K; Kato T; Takahashi S
Mechanistic analysis of multistage carcinogenesis in the rat prostate.
Princess Takamatsu symposia 1991;22():125-33.
1990: Nakamura A; Shirai T; Ogawa K; Wada S; Fujimoto N A; Ito A; Ito N
Promoting action of prolactin released from a grafted transplantable pituitary tumor (MtT/F84) on rat prostate carcinogenesis.
Cancer letters 1990;53(2-3):151-7.
1990: Kurata Y; Fukushima S; Hasegawa R; Hirose M; Shibata M; Shirai T; Ito N
Structure-activity relations in promotion of rat urinary bladder carcinogenesis by phenolic antioxidants.
Japanese journal of cancer research : Gann 1990;81(8):754-9.
1990: Tatematsu M; Katsuyama T; Furihata C; Fukushima S; Shirai T; Kato T; Ito N
Cellular differentiation and histogenesis of rat glandular stomach cancers.
Japanese journal of cancer research : Gann 1990;81(8):760-7.
1990: Fukushima S; Uwagawa S; Shirai T; Hasegawa R; Ogawa K
Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis.
Cancer research 1990;50(14):4195-8.
1990: Shirai T; Nakamura A; Fukushima S; Yamamoto A; Tada M; Ito N
Different carcinogenic responses in a variety of organs, including the prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl.
Carcinogenesis 1990;11(5):793-7.
1990: Hasegawa R; Takahashi S; Asamoto M; Shirai T; Fukushima S
Species differences in sodium o-phenylphenate induction of urinary bladder lesions.
Cancer letters 1990;50(2):87-91.
1990: Shirai T; Nakamura A; Fukushima S; Tada M; Morita T; Ito N
Immunohistochemical demonstration of carcinogen-DNA adducts in target and non-target tissues of rats given a prostate carcinogen, 3,2'-dimethyl-4-aminobiphenyl.
Carcinogenesis 1990;11(4):653-7.
1990: Shirai T; Nakamura A; Fukushima S; Wang C Y; Yamada H; Ito N
Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl.
Japanese journal of cancer research : Gann 1990;81(4):320-3.
1990: Hirose M; Fukushima S; Shirai T; Hasegawa R; Kato T; Tanaka H; Asakawa E; Ito N
Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.
Japanese journal of cancer research : Gann 1990;81(3):207-12.
1989: Ito N; Hirose M; Shibata M; Tanaka H; Shirai T
Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2'-dimethyl-4-aminobiphenyl, 2,2'-dihydroxy-di-n-propylnitrosamine and N-methylnitrosourea.
Carcinogenesis 1989;10(12):2255-9.
1989: Hirose M; Kurata Y; Yamada M; Shirai T; Ito N; Ohsawa T
Lack of modifying effects of linolic acid hydroperoxides and their secondary oxidative products on combined 7,12-dimethylbenz[a]anthracene and 1,2-dimethylhydrazine-initiated mammary gland, ear duct and colon carcinogenesis in female Sprague-Dawley rats.
Cancer letters 1989;47(1-2):141-7.
1989: Shirai T; Nakamura A; Wada S; Ito N
Pancreatic acinar cell tumors in rats induced by 3,2'-dimethyl-4-aminobiphenyl.
Carcinogenesis 1989;10(6):1127-30.
1989: Shirai T; Nakamura A; Fukushima S; Takahashi S; Ogawa K; Ito N
Effects of age on multiple organ carcinogenesis induced by 3,2'-dimethyl-4-aminobiphenyl in rats, with particular reference to the prostate.
Japanese journal of cancer research : Gann 1989;80(4):312-6.
1989: Shirai T; Fukushima S; Tagawa Y; Okumura M; Ito N
Cell proliferation induced by uracil-calculi and subsequent development of reversible papillomatosis in the rat urinary bladder.
Cancer research 1989;49(2):378-83.
1988: Shirai T; Tagawa Y; Taguchi O; Ikawa E; Mutai M; Fukushima S; Ito N
Low tumorigenic response to 3,2'-dimethyl-4-aminobiphenyl administration in the prostate of rats castrated at birth.
Japanese journal of cancer research : Gann 1988;79(12):1293-6.
1988: Masui T; Shirai T; Takahashi S; Mutai M; Fukushima S
Summation effect of uracil on the two-stage and multistage models of urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis 1988;9(11):1981-5.
1988: Fukushima S; Imaida K; Shibata M A; Tamano S; Kurata Y; Shirai T
L-ascorbic acid amplification of second-stage bladder carcinogenesis promotion by NaHCO3.
Cancer research 1988;48(22):6317-20.
1988: Ito N; Shirai T; Tagawa Y; Nakamura A; Fukushima S
Variation in tumor yield in the prostate and other target organs of the rat in response to varied dosage and duration of administration of 3,2'-dimethyl-4-aminobiphenyl.
Cancer research 1988;48(16):4629-32.
1988: Shirai T; Masuda A; Imaida K; Ogiso T; Ito N
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Japanese journal of cancer research : Gann 1988;79(4):460-5.
1988: Masui T; Shirai T; Imaida K; Uwagawa S; Fukushima S
Effects of urinary crystals induced by acetazolamide, uracil, and diethylene glycol on urinary bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated rats.
Toxicology letters 1988;40(2):119-26.
1987: Shirai T; Tagawa Y; Fukushima S; Imaida K; Ito N
Strong promoting activity of reversible uracil-induced urolithiasis on urinary bladder carcinogenesis in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Cancer research 1987;47(24 Pt 1):6726-30.
1987: Shirai T; Fukushima S; Hirose M; Ohshima M; Ito N
Epithelial lesions of the urinary bladder in three hundred and thirteen autopsy cases.
Japanese journal of cancer research : Gann 1987;78(10):1073-80.

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