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Kuniaki Shirao

Research Profile

Genes & Molecular Sequences

Single Nucleotide Polymorphism

Physiology

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Japan

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TOP 3
Kimie Sai; Yoshiro Saito; Naoko Tatewaki; Masakiyo Hosokawa; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Mikihiko Naito; Jun-Ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Tomohide Tamura; Yasuhide Yamada; Yuichiro Ohe; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Yasuhiro Matsumura; Nagahiro Saijo; Haruhiro Okuda
Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.
Kimie Sai; Yoshiro Saito; Keiko Maekawa; Su-Ryang Kim; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Jun-ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Hironobu Minami
Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.
Kimie Sai; Yoshiro Saito; Hiromi Fukushima-Uesaka; Koichi Kurose; Nahoko Kaniwa; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Tetsuya Hamaguchi; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Yasuhide Yamada; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients.

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All Publications

2010: Kimie Sai; Yoshiro Saito; Naoko Tatewaki; Masakiyo Hosokawa; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Mikihiko Naito; Jun-Ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Tomohide Tamura; Yasuhide Yamada; Yuichiro Ohe; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Yasuhiro Matsumura; Nagahiro Saijo; Haruhiro Okuda
Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients.
British journal of clinical pharmacology 2010;70(2):222-33.
2010: Kimie Sai; Yoshiro Saito; Keiko Maekawa; Su-Ryang Kim; Nahoko Kaniwa; Tomoko Nishimaki-Mogami; Jun-ichi Sawada; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Hironobu Minami
Additive effects of drug transporter genetic polymorphisms on irinotecan pharmacokinetics/pharmacodynamics in Japanese cancer patients.
Cancer chemotherapy and pharmacology 2010;66(1):95-105.
2008: Kimie Sai; Yoshiro Saito; Hiromi Fukushima-Uesaka; Koichi Kurose; Nahoko Kaniwa; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Tetsuya Hamaguchi; Hideo Kunitoh; Yuichiro Ohe; Tomohide Tamura; Yasuhide Yamada; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Impact of CYP3A4 haplotypes on irinotecan pharmacokinetics in Japanese cancer patients.
Cancer chemotherapy and pharmacology 2008;62(3):529-37.
2008: Kimie Sai; Yoshiro Saito; Masaya Itoda; Hiromi Fukushima-Uesaka; Tomoko Nishimaki-Mogami; Shogo Ozawa; Keiko Maekawa; Kouichi Kurose; Nahoko Kaniwa; Manabu Kawamoto; Naoyuki Kamatani; Kuniaki Shirao; Tetsuya Hamaguchi; Noboru Yamamoto; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Yasuhiro Matsumura; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population.
Drug metabolism and pharmacokinetics 2008;23(2):139-47.
2007: Su-Ryang Kim; Yoshiro Saito; Kimie Sai; Kouichi Kurose; Keiko Maekawa; Nahoko Kaniwa; Shogo Ozawa; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Tetsuya Hamaguchi; Hideo Kunitoh; Yuichiro Ohe; Yasuhide Yamada; Tomohide Tamura; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and frequencies of major haplotypes in SLCO1B1 encoding the transporter OATP1B1 in Japanese subjects: SLCO1B1*17 is more prevalent than *15.
Drug metabolism and pharmacokinetics 2007;22(6):456-61.
2007: Su-Ryang Kim; Kimie Sai; Toshiko Tanaka-Kagawa; Hideto Jinno; Shogo Ozawa; Nahoko Kaniwa; Yoshiro Saito; Akira Akasawa; Kenji Matsumoto; Hirohisa Saito; Naoyuki Kamatani; Kuniaki Shirao; Noboru Yamamoto; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Haplotypes and a novel defective allele of CES2 found in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1865-72.
2007: Keiko Maekawa; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Kouichi Kurose; Nahoko Kaniwa; Manabu Kawamoto; Naoyuki Kamatani; Ken Kato; Tetsuya Hamaguchi; Yasuhide Yamada; Kuniaki Shirao; Yasuhiro Shimada; Manabu Muto; Toshihiko Doi; Atsushi Ohtsu; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Jun-ichi Sawada
Genetic variations and haplotype structures of the DPYD gene encoding dihydropyrimidine dehydrogenase in Japanese and their ethnic differences.
Journal of human genetics 2007;52(10):804-19.
2006: Su-Ryang Kim; Shogo Ozawa; Yoshiro Saito; Kouichi Kurose; Nahoko Kaniwa; Naoyuki Kamatani; Tetsuya Hamaguchi; Kuniaki Shirao; Manabu Muto; Atsushi Ohtsu; Teruhiko Yoshida; Yasuhiro Matsumura; Nagahiro Saijo; Jun-ichi Sawada
Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS).
Drug metabolism and pharmacokinetics 2006;21(6):509-16.
2006: Kimie Sai; Masaya Itoda; Yoshiro Saito; Kouichi Kurose; Noriko Katori; Nahoko Kaniwa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Hitonobu Tomoike; Shiro Kamakura; Masafumi Kitakaze; Toru Tamura; Noboru Yamamoto; Hideo Kunitoh; Yasuhide Yamada; Yuichiro Ohe; Yasuhiro Shimada; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variations and haplotype structures of the ABCB1 gene in a Japanese population: an expanded haplotype block covering the distal promoter region, and associated ethnic differences.
Annals of human genetics 2006;70(Pt 5):605-22.
2006: Keiko Maekawa; Masaya Itoda; Kimie Sai; Yoshiro Saito; Nahoko Kaniwa; Kuniaki Shirao; Tetsuya Hamaguchi; Hideo Kunitoh; Noboru Yamamoto; Tomohide Tamura; Hironobu Minami; Kaoru Kubota; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Genetic variation and haplotype structure of the ABC transporter gene ABCG2 in a Japanese population.
Drug metabolism and pharmacokinetics 2006;21(2):109-21.
2006: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Shogo Ozawa; Kouichi Kurose; Nahoko Kaniwa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kuniaki Shirao; Toru Tamura; Noboru Yamamoto; Hideo Kunitoh; Tetsuya Hamaguchi; Teruhiko Yoshida; Kaoru Kubota; Atsushi Ohtsu; M Muto; Hironobu Minami; Nagahiro Saijo; Naoyuki Kamatani; Jun-ichi Sawada
Haplotype structures of the UGT1A gene complex in a Japanese population.
The pharmacogenomics journal 2006;6(1):63-75.
2005: Takashi Kubo; Su-Ryang Kim; Kimie Sai; Yoshiro Saito; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Kuniaki Shirao; Noboru Yamamoto; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yasuo Ohno; Shogo Ozawa; Jun-ichi Sawada
Functional characterization of three naturally occurring single nucleotide polymorphisms in the CES2 gene encoding carboxylesterase 2 (HCE-2).
Drug metabolism and disposition: the biological fate of chemicals 2005;33(10):1482-7.
2005: Shinobu Ikeda; Kouichi Kurose; Hideto Jinno; Kimie Sai; Shogo Ozawa; Ryuichi Hasegawa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Tomohide Tamura; Noboru Yamamoto; Hideo Kunitoh; Yasuhide Yamada; Yuichiro Ohe; Yasuhiro Shimada; Kuniaki Shirao; Kaoru Kubota; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Functional analysis of four naturally occurring variants of human constitutive androstane receptor.
Molecular genetics and metabolism 2005;86(1-2):314-9.
2005: Satoru Koyano; Yoshiro Saito; Hiromi Fukushima-Uesaka; Seiichi Ishida; Shogo Ozawa; Naoyuki Kamatani; Hironobu Minami; Atsushi Ohtsu; Tetsuya Hamaguchi; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo; Hideto Jinno; Jun-ichi Sawada
Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(8):1254-60.
2005: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Akiko Hachisuka; Nahoko Kaniwa; Shogo Ozawa; Manabu Kawamoto; Naoyuki Kamatani; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Jun-ichi Sawada
Genetic variations and haplotypes of UGT1A4 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(2):144-51.
2005: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Nahoko Kaniwa; Shogo Ozawa; Kazuo Komamura; Takeshi Kotake; Hideki Morishita; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Naoyuki Kamatani; Jun-ichi Sawada
Genetic polymorphisms of UGT1A6 in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):85-90.
2005: Satoru Koyano; Yoshiro Saito; Kimie Sai; Kouichi Kurose; Shogo Ozawa; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Kuniaki Shirao; Teruhiko Yoshida; Hironobu Minami; Atsushi Ohtsu; Nagahiro Saijo; Jun-ichi Sawada
Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2005;20(1):79-84.
2004: Hiromi Fukushima-Uesaka; Kimie Sai; Keiko Maekawa; Satoru Koyano; Nahoko Kaniwa; Shogo Ozawa; Manabu Kawamoto; Naoyuki Kamatani; Kazuo Komamura; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Kazuyuki Ueno; Hironobu Minami; Atsushi Ohtsu; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Genetic variations of the AHR gene encoding aryl hydrocarbon receptor in a Japanese population.
Drug metabolism and pharmacokinetics 2004;19(4):320-6.
2004: Kimie Sai; Mayumi Saeki; Yoshiro Saito; Shogo Ozawa; Noriko Katori; Hideto Jinno; Ryuichi Hasegawa; Nahoko Kaniwa; Jun-ichi Sawada; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Yutaka Kitamura; Naoyuki Kamatani; Hironobu Minami; Atsushi Ohtsu; Kuniaki Shirao; Teruhiko Yoshida; Nagahiro Saijo
UGT1A1 haplotypes associated with reduced glucuronidation and increased serum bilirubin in irinotecan-administered Japanese patients with cancer.
Clinical pharmacology and therapeutics 2004;75(6):501-15.
2003: Kimie Sai; Nahoko Kaniwa; Masaya Itoda; Yoshiro Saito; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yutaka Kitamura; Naoyuki Kamatani; Shogo Ozawa; Jun-ichi Sawada
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan.
Pharmacogenetics 2003;13(12):741-57.
2003: Hideto Jinno; Mayumi Saeki; Yoshiro Saito; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Kimie Sai; Nahoko Kaniwa; Masanori Ando; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients.
The Journal of pharmacology and experimental therapeutics 2003;306(2):688-93.
2003: Hideto Jinno; Mayumi Saeki; Toshiko Tanaka-Kagawa; Nobumitsu Hanioka; Yoshiro Saito; Shogo Ozawa; Masanori Ando; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(5):528-32.
2003: Shinobu Ikeda; Kouichi Kurose; Shogo Ozawa; Kimie Sai; Ryuichi Hasegawa; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Hitonobu Tomoike; Toshiharu Nakajima; Kenji Matsumoto; Hirohisa Saito; Yu-Ichi Goto; Hideo Kimura; Masaaki Katoh; Kenji Sugai; Narihiro Minami; Kuniaki Shirao; Tomohide Tamura; Noboru Yamamoto; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Yoshiro Saito; Jun-ichi Sawada
Twenty-six novel single nucleotide polymorphisms and their frequencies of the NR1I3 (CAR) gene in a Japanese population.
Drug metabolism and pharmacokinetics 2003;18(6):413-8.
2003: Su-Ryang Kim; Takahiro Nakamura; Yoshiro Saito; Kimie Sai; Toshiharu Nakajima; Hirohisa Saito; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2).
Drug metabolism and pharmacokinetics 2003;18(5):327-32.
2003: Masaya Itoda; Yoshiro Saito; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Hiroshi Suzuki; Yuichi Sugiyama; Shogo Ozawa; Jun-ichi Sawada
Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.
Drug metabolism and pharmacokinetics 2003;18(3):212-7.
2003: Mayumi Saeki; Yoshiro Saito; Hideto Jinno; Kimie Sai; Kazuo Komamura; Kazuyuki Ueno; Shiro Kamakura; Masafumi Kitakaze; Kuniaki Shirao; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Shogo Ozawa; Jun-ichi Sawada
Three novel single nucleotide polymorphisms in UGT1A9.
Drug metabolism and pharmacokinetics 2003;18(2):146-9.
2002: Mayumi Saeki; Shogo Ozawa; Yoshiro Saito; Hideto Jinno; Tetsuya Hamaguchi; Hiroshi Nokihara; Yasuhiro Shimada; Hideo Kunitoh; Noboru Yamamoto; Yuichiro Ohe; Yasuhide Yamada; Kuniaki Shirao; Manabu Muto; Kiyomi Mera; Koichi Goto; Hironobu Ohmatsu; Kaoru Kubota; Seiji Niho; Ryutaro Kakinuma; Hironobu Minami; Atsushi Ohtsu; Teruhiko Yoshida; Nagahiro Saijo; Jun-ichi Sawada
Three novel single nucleotide polymorphisms in UGT1A10.
Drug metabolism and pharmacokinetics 2002;17(5):488-90.