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David Shire

Research Profile

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Chemicals & Drugs

Genes & Molecular Sequences

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Anne Remaury; Natalio VITA; Sylvain Gendreau; Mireille Jung; Michèle Arnone; Martine Poncelet; Jean-Michel Culouscou; Gérard Le-Fur; Philippe Soubrié; Daniel Caput; David Shire; Manfred Kopf; Pascual Ferrara
Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia.
Paul R Gouldson; B Calandra; P Legoux; A Kernéis; Murielle Rinaldi-Carmona; Francis Barth; Gérard Le-Fur; Pascual Ferrara; David Shire
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor.
Paul R Gouldson; P Legoux; C Carillon; B Delpech; Gérard Le-Fur; Pascual Ferrara; David Shire
The agonist SR 146131 and the antagonist SR 27897 occupy different sites on the human CCK(1) receptor.

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All Publications

2002: Anne Remaury; Natalio VITA; Sylvain Gendreau; Mireille Jung; Michèle Arnone; Martine Poncelet; Jean-Michel Culouscou; Gérard Le-Fur; Philippe Soubrié; Daniel Caput; David Shire; Manfred Kopf; Pascual Ferrara
Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia.
Brain research 2002;953(1-2):63-72.
2000: Paul R Gouldson; B Calandra; P Legoux; A Kernéis; Murielle Rinaldi-Carmona; Francis Barth; Gérard Le-Fur; Pascual Ferrara; David Shire
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor.
European journal of pharmacology 2000;401(1):17-25.
2000: Paul R Gouldson; P Legoux; C Carillon; B Delpech; Gérard Le-Fur; Pascual Ferrara; David Shire
The agonist SR 146131 and the antagonist SR 27897 occupy different sites on the human CCK(1) receptor.
European journal of pharmacology 2000;400(2-3):185-94.
2000: Paul R Gouldson; P Legoux; C Carillon; X Dumont; Gérard Le-Fur; Pascual Ferrara; David Shire
Essential role of extracellular charged residues of the human CCK(1) receptor for interactions with SR 146131, SR 27897 and CCK-8S.
European journal of pharmacology 2000;389(2-3):115-24.
2000: David Shire; P Legoux
Gene expression analysis using quantitative reverse transcription-polymerase chain reaction and a multispecific internal control.
Methods in molecular biology (Clifton, N.J.) 2000;137():59-73.
1999: Paul R Gouldson; P Legoux; C Carillon; B Delpech; Gérard Le-Fur; Pascual Ferrara; David Shire
Contrasting roles of leu(356) in the human CCK(1) receptor for antagonist SR 27897 and agonist SR 146131 binding.
European journal of pharmacology 1999;383(3):339-46.
1999: B Calandra; M Portier; A Kernéis; M Delpech; C Carillon; Gérard Le-Fur; Pascual Ferrara; David Shire
Dual intracellular signaling pathways mediated by the human cannabinoid CB1 receptor.
European journal of pharmacology 1999;374(3):445-55.
1999: David Shire; B Calandra; Monsif Bouaboula; Francis Barth; Murielle Rinaldi-Carmona; Pierre Casellas; Pascual Ferrara
Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528.
Life sciences 1999;65(6-7):627-35.
1998: Murielle Rinaldi-Carmona; Francis Barth; J Millan; Jean-Marie Derocq; Pierre Casellas; C Congy; Didier Oustric; M Sarran; Monsif Bouaboula; B Calandra; M Portier; David Shire; J C Brelière; Gérard Le-Fur
SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor.
The Journal of pharmacology and experimental therapeutics 1998;284(2):644-50.
1998: E Joseph-Liauzun; P Delmas; David Shire; Pascual Ferrara
Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five-transmembrane structure.
The Journal of biological chemistry 1998;273(4):2146-52.
1997: A Minty; S Asselin; Armand Bensussan; David Shire; Natalio VITA; A Vyakarnam; John Wijdenes; Pascual Ferrara; Daniel Caput
The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes.
European cytokine network 1997;8(2):203-13.
1996: R Legoux; P Lelong; C Jourde; C Feuillerat; Joël Capdevielle; V Sure; E Ferran; Mourad Kaghad; B Delpech; David Shire; Pascual Ferrara; Gérard Loison; M Salomé
N-acetyl-heparosan lyase of Escherichia coli K5: gene cloning and expression.
Journal of bacteriology 1996;178(24):7260-4.
1996: Sandra Silve; Pascal-Henri Dupuy; C Labit-Lebouteiller; Mourad Kaghad; Pascale Chalon; Alain Rahier; M Taton; JH Lupker; David Shire; Gérard Loison
Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast.
The Journal of biological chemistry 1996;271(37):22434-40.
1996: Murielle Rinaldi-Carmona; B Calandra; David Shire; Monsif Bouaboula; D Oustric; Francis Barth; Pierre Casellas; Pascual Ferrara; Gérard Le-Fur
Characterization of two cloned human CB1 cannabinoid receptor isoforms.
The Journal of pharmacology and experimental therapeutics 1996;278(2):871-8.
1996: David Shire; B Calandra; Murielle Rinaldi-Carmona; D Oustric; B Pessègue; O Bonnin-Cabanne; Gérard Le-Fur; Daniel Caput; Pascual Ferrara
Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.
Biochimica et biophysica acta 1996;1307(2):132-6.
1996: F Pousset; J Fournier; P Legoux; Peter Keane; David Shire; Philippe Soubrie
Effect of serotonin on cytokine mRNA expression in rat hippocampal astrocytes.
Brain research. Molecular brain research 1996;38(1):54-62.
1996: David Shire; B Calandra; M Delpech; X Dumont; Mourad Kaghad; Gérard Le-Fur; Daniel Caput; Pascual Ferrara
Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A.
The Journal of biological chemistry 1996;271(12):6941-6.
1995: Sylvaine Galiègue; S Mary; Jean Marchand; Danielle Dussossoy; D Carrière; Pierre Carayon; Monsif Bouaboula; David Shire; Gérard Le-Fur; Pierre Casellas
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.
European journal of biochemistry / FEBS 1995;232(1):54-61.
1995: Monsif Bouaboula; Bernard Bourrié; Murielle Rinaldi-Carmona; David Shire; Gérard Le-Fur; Pierre Casellas
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells.
The Journal of biological chemistry 1995;270(23):13973-80.
1995: M Rodriguez; C Carillon; A Coquerel; Gérard Le-Fur; Pascual Ferrara; Daniel Caput; David Shire
Evidence for the presence of beta 3-adrenergic receptor mRNA in the human brain.
Brain research. Molecular brain research 1995;29(2):369-75.
1995: David Shire; C Carillon; Mourad Kaghad; B Calandra; Murielle Rinaldi-Carmona; Gérard Le-Fur; Daniel Caput; Pascual Ferrara
An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.
The Journal of biological chemistry 1995;270(8):3726-31.
1995: Murielle Rinaldi-Carmona; Francis Barth; M Héaulme; R Alonso; David Shire; C Congy; Philippe Soubrié; JC Brelière; Gérard Le-Fur
Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist.
Life sciences 1995;56(23-24):1941-7.
1994: R Farges; E Joseph-Liauzun; David Shire; Daniel Caput; Gérard Le-Fur; Pascual Ferrara
Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864.
Molecular pharmacology 1994;46(6):1160-7.
1994: Murielle Rinaldi-Carmona; Francis Barth; M Héaulme; David Shire; B Calandra; C Congy; S Martinez; J Maruani; G Néliat; Daniel Caput
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor.
FEBS letters 1994;350(2-3):240-4.
1993: R Farges; E Joseph-Liauzun; David Shire; Daniel Caput; Gérard Le-Fur; Gérard Loison; Pascual Ferrara
Molecular basis for the different binding properties of benzodiazepines to human and bovine peripheral-type benzodiazepine receptors.
FEBS letters 1993;335(3):305-8.
1993: Murielle Rinaldi-Carmona; Monsif Bouaboula; C Congy; Florence Oury-Donat; Jacques Simiand; David Shire; Pierre Casellas; Philippe Soubrié; JC Brelière; Gérard Le-Fur
Up-regulation of 5-HT2 receptors in the rat brain by repeated administration of SR 46349B, a selective 5-HT2 receptor antagonist.
European journal of pharmacology 1993;246(1):73-80.
1993: Monsif Bouaboula; M Rinaldi; P Carayon; C Carillon; B Delpech; David Shire; Gérard Le-Fur; Pierre Casellas
Cannabinoid-receptor expression in human leukocytes.
European journal of biochemistry / FEBS 1993;214(1):173-80.
1993: E Pascolo; C Blonski; David Shire; Jean-Jacques Toulmé
Antisense effect of oligodeoxynucleotides complementary to the mini-exon sequence of the protozoan parasite Leishmania amazonensis.
Biochimie 1993;75(1-2):43-7.
1993: X Canat; Pierre Carayon; Monsif Bouaboula; D Cahard; David Shire; C Roque; Gérard Le-Fur; Pierre Casellas
Distribution profile and properties of peripheral-type benzodiazepine receptors on human hemopoietic cells.
Life sciences 1993;52(1):107-18.
1993: Roland Lloubès; Natalio VITA; A Bernadac; David Shire; P Leplatois; Vincent Géli; M Frenette; M Knibiehler; Claude Lazdunski; Daniel Baty
Colicin A lysis protein promotes extracellular release of active human growth hormone accumulated in Escherichia coli cytoplasm.
Biochimie 1993;75(6):451-8.
1992: B Larrouy; C Blonski; Claudine Boiziau; M Stuer; S Moreau; David Shire; Jean-Jacques Toulmé
RNase H-mediated inhibition of translation by antisense oligodeoxyribonucleotides: use of backbone modification to improve specificity.
Gene 1992;121(2):189-94.
1992: Claudine Boiziau; B Larrouy; S Moreau; C Cazenave; David Shire; Jean-Jacques Toulmé
Ribonuclease H-mediated inhibition of translation and reverse transcription by antisense oligodeoxynucleotides.
Biochemical Society transactions 1992;20(4):764-7.
1992: P Legoux; C Minty; B Delpech; A J Minty; David Shire
Simultaneous quantitation of cytokine mRNAs in interleukin-1 beta stimulated U373 human astrocytoma cells by a polymerisation chain reaction method involving co-amplification with an internal multi-specific control.
European cytokine network 1992;3(6):553-63.
1992: Monsif Bouaboula; P Legoux; B Pességué; B Delpech; X Dumont; Marc Piechaczyk; Pierre Casellas; David Shire
Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control.
The Journal of biological chemistry 1992;267(30):21830-8.
1992: C Job; David Shire; V Sure; Dominique Job
A DNA-dependent RNA synthesis by wheat-germ RNA polymerase II insensitive to the fungal toxin alpha-amanitin.
The Biochemical journal 1992;285 ( Pt 1)():85-90.
1992: R Legoux; B Delpech; X Dumont; J C Guillemot; P Ramond; David Shire; Daniel Caput; Pascual Ferrara; Gérard Loison
Cloning and expression in Escherichia coli of the gene encoding Aspergillus flavus urate oxidase.
The Journal of biological chemistry 1992;267(12):8565-70.
1992: Jacques Dornand; Monsif Bouaboula; A D d'Angeac; Jean Favero; David Shire; Pierre Casellas
Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line.
Journal of cellular physiology 1992;151(1):71-80.
1991: C Blonski; Pascale Chalon; David Shire
Acridine-linked oligonucleotide probes for the short dAT-rich motifs in the 3'-untranslated region of cytokine genes.
European cytokine network 1991;2(3):217-24.
1991: Dominique Job; C Job; L de Mercoyrol; David Shire
Transcription of synthetic DNA containing sequences with dyad symmetry by wheat-germ RNA polymerase II. Increased rates of product release in single-step addition reactions.
European journal of biochemistry / FEBS 1991;195(3):831-9.
1991: F Pecceu; P Dousset; David Shire; E Cavrois; E Marchese; Pascual Ferrara; Mourad Kaghad; X Dumont; JH Lupker
Human interleukin 1 beta fused to the human growth hormone signal peptide is N-glycosylated and secreted by Chinese hamster ovary cells.
Gene 1991;97(2):253-8.
1991: C Blonski; C Carillon; B Delpech; B Pességué; Pascale Chalon; David Shire
Investigation into the use of very short oligonucleotide probes for identifying DNA and RNA sequences containing characteristic d(AT) and AU motifs.
Nucleic acids symposium series 1991;(24):296.
1991: Claudine Boiziau; C Blonski; Nguyen T Thuong; David Shire; J J Toulme
Inhibition of reverse transcription by unmodified and modified antisense oligodeoxynucleotides.
Nucleic acids symposium series 1991;(24):121-5.
1990: N Loreau; Claudine Boiziau; P Verspieren; David Shire; Jean-Jacques Toulmé
Blockage of AMV reverse transcriptase by antisense oligodeoxynucleotides.
FEBS letters 1990;274(1-2):53-6.
1990: David Shire; Bernard Bourrié; C Carillon; Jean-Marie Derocq; P Dousset; X Dumont; F K Jansen; Mourad Kaghad; R Legoux; P Lelong
Biologically active A-chain of the plant toxin ricin expressed from a synthetic gene in Escherichia coli.
Gene 1990;93(2):183-8.
1990: P Verspieren; N Loreau; Nguyen T Thuong; David Shire; Jean-Jacques Toulmé
Effect of RNA secondary structure and modified bases on the inhibition of trypanosomatid protein synthesis in cell free extracts by antisense oligodeoxynucleotides.
Nucleic acids research 1990;18(16):4711-7.
1989: S Varenne; Daniel Baty; H Verheij; David Shire; Claude Lazdunski
The maximum rate of gene expression is dependent on the downstream context of unfavourable codons.
Biochimie 1989;71(11-12):1221-9.
1989: vincent geli; Daniel Baty; M Knibiehler; Roland Lloubès; B Pessegue; David Shire; Claude Lazdunski
Synthesis and sequence-specific proteolysis of a hybrid protein (colicin A::growth hormone releasing factor) produced in Escherichia coli.
Gene 1989;80(1):129-36.
1988: Dominique Job; J M Soulié; C Job; David Shire
Potential memory and hysteretic effects in transcription.
Journal of theoretical biology 1988;134(3):273-89.
1988: Alain Viari; J P Ballini; P Meleard; Paul Vigny; P Dousset; C Blonski; David Shire
Characterization and sequencing of normal and modified oligonucleotides by 252Cf plasma desorption mass spectrometry.
Biomedical & environmental mass spectrometry 1988;16(1-12):225-8.
1987: C Job; J Dietrich; David Shire; M Teissere; D Job
Effect of low nucleotide concentrations on abortive elongation catalysed by wheat-germ RNA polymerase II.
The Biochemical journal 1987;244(1):151-7.
1987: Daniel Baty; M Knibiehler; H Verheij; Franc Pattus; David Shire; A Bernadac; Claude Lazdunski
Site-directed mutagenesis of the COOH-terminal region of colicin A: effect on secretion and voltage-dependent channel activity.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(5):1152-6.
1987: J Anba; Daniel Baty; Roland Lloubès; Jean-Marie Pagès; E Joseph-Liauzun; David Shire; W Roskam; Claude Lazdunski
Expression vector promoting the synthesis and export of the human growth-hormone-releasing factor in Escherichia coli.
Gene 1987;53(2-3):219-26.