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Assia Shisheva

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Diego Sbrissa; Khortnal Delvecchio; Catherine Filios; Ognian C Ikonomov; Assia Shisheva
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
Assia Shisheva
PIKfyve and its Lipid products in health and in sickness.
Ognian C Ikonomov; Diego Sbrissa; Khortnal Delvecchio; Yufen Xie; J-P Jin; Daniel A Rappolee; Assia Shisheva
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.

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All Publications

2012: Diego Sbrissa; Khortnal Delvecchio; Catherine Filios; Ognian C Ikonomov; Assia Shisheva
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
American journal of physiology. Cell physiology 2012;303(4):C436-46.
2012: Assia Shisheva
PIKfyve and its Lipid products in health and in sickness.
Current topics in microbiology and immunology 2012;362():127-62.
2011: Ognian C Ikonomov; Diego Sbrissa; Khortnal Delvecchio; Yufen Xie; J-P Jin; Daniel A Rappolee; Assia Shisheva
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
The Journal of biological chemistry 2011;286(15):13404-13.
2010: Ognian C Ikonomov; Diego Sbrissa; Jason Fligger; Khortnal Delvecchio; Assia Shisheva
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
The Journal of biological chemistry 2010;285(35):26760-4.
2009: Ognian C Ikonomov; Diego Sbrissa; Homer Fenner; Assia Shisheva
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
The Journal of biological chemistry 2009;284(51):35794-806.
2009: Ognian C Ikonomov; Diego Sbrissa; Takeshi Ijuin; Tadaomi Takenawa; Assia Shisheva
Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.
The Journal of biological chemistry 2009;284(36):23961-71.
2009: Ognian C Ikonomov; Diego Sbrissa; Assia Shisheva
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.
Biochemical and biophysical research communications 2009;382(3):566-70.
2009: Ognian C Ikonomov; Jason Fligger; Diego Sbrissa; Rajeswari Dondapati; Krzysztof Mlak; Robert Deeb; Assia Shisheva
Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin.
The Journal of biological chemistry 2009;284(6):3750-61.
2008: Diego Sbrissa; Ognian C Ikonomov; Homer Fenner; Assia Shisheva
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
Journal of molecular biology 2008;384(4):766-79.
2008: Assia Shisheva
Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3.
American journal of physiology. Endocrinology and metabolism 2008;295(3):E536-44.
2008: Assia Shisheva
PIKfyve: Partners, significance, debates and paradoxes.
Cell biology international 2008;32(6):591-604.
2007: Jayoung Kim; Wan Jin Jahng; Dolores Di Vizio; Julie S Lee; Raj Jhaveri; Mark A Rubin; Assia Shisheva; Michael R Freeman
The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus.
Cancer research 2007;67(19):9229-37.
2007: Diego Sbrissa; Ognian C Ikonomov; Zhiyao Fu; Takeshi Ijuin; Jean Gruenberg; Tadaomi Takenawa; Assia Shisheva
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
The Journal of biological chemistry 2007;282(33):23878-91.
2007: Ognian C Ikonomov; Diego Sbrissa; Rajeswari Dondapati; Assia Shisheva
ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.
Experimental cell research 2007;313(11):2404-16.
2006: Anne M Kong; Kristy A Horan; Absorn Sriratana; Charles G Bailey; Luke J Collyer; Harshal H Nandurkar; Assia Shisheva; Meredith J Layton; John Rasko; Tony Rowe; Christina A Mitchell
Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.
Molecular and cellular biology 2006;26(16):6065-81.
2006: Ognian C Ikonomov; Diego Sbrissa; Assia Shisheva
Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion.
American journal of physiology. Cell physiology 2006;291(2):C393-404.
2006: Yong Xu; Stephanie A Lee; Tatiana G Kutateladze; Diego Sbrissa; Assia Shisheva; Glenn D Prestwich
Chemical synthesis and molecular recognition of phosphatase-resistant analogues of phosphatidylinositol-3-phosphate.
Journal of the American Chemical Society 2006;128(3):885-97.
2005: Diego Sbrissa; Assia Shisheva
Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway.
The Journal of biological chemistry 2005;280(9):7883-9.
2005: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
Analysis of potential binding of the recombinant Rab9 effector p40 to phosphoinositide-enriched synthetic liposomes.
Methods in enzymology 2005;403():696-705.
2004: Diego Sbrissa; Ognian C Ikonomov; Jana Strakova; Rajeswari Dondapati; Krzysztof Mlak; Robert Deeb; Robert B Silver; Assia Shisheva
A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity.
Molecular and cellular biology 2004;24(23):10437-47.
2004: Diego Sbrissa; Ognian C Ikonomov; Jana Strakova; Assia Shisheva
Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation.
Endocrinology 2004;145(11):4853-65.
2004: Kenichi Tsujita; Toshiki Itoh; Takeshi Ijuin; Akitsugu Yamamoto; Assia Shisheva; Jocelyn Laporte; Tadaomi Takenawa
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interaction.
The Journal of biological chemistry 2004;279(14):13817-24.
2003: Ognian C Ikonomov; Diego Sbrissa; Krzysztof Mlak; Robert Deeb; Jason Fligger; Aleric Soans; Russell L Finley; Assia Shisheva
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
The Journal of biological chemistry 2003;278(51):50863-71.
2003: Ognian C Ikonomov; Diego Sbrissa; Michelangelo Foti; Jean-Louis Carpentier; Assia Shisheva
PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis.
Molecular biology of the cell 2003;14(11):4581-91.
2003: Assia Shisheva
Regulating Glut4 vesicle dynamics by phosphoinositide kinases and phosphoinositide phosphatases.
Frontiers in bioscience : a journal and virtual library 2003;8():s945-6.
2002: Diego Sbrissa; Ognian C Ikonomov; Robert Deeb; Assia Shisheva
Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells.
The Journal of biological chemistry 2002;277(49):47276-84.
2002: Ognian C Ikonomov; Diego Sbrissa; Krzysztof Mlak; Assia Shisheva
Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects.
Endocrinology 2002;143(12):4742-54.
2002: Ognian C Ikonomov; Diego Sbrissa; Tamotsu Yoshimori; Timothy L Cover; Assia Shisheva
PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin.
The Journal of biological chemistry 2002;277(48):46785-90.
2002: Ognian C Ikonomov; Diego Sbrissa; Krzysztof Mlak; Makoto Kanzaki; Jeffrey Pessin; Assia Shisheva
Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity.
The Journal of biological chemistry 2002;277(11):9206-11.
2002: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.
The Journal of biological chemistry 2002;277(8):6073-9.
2001: George Grunberger; Xiaoling Qiang; Zhen-Guo Li; Suresh T Mathews; Diego Sbrissa; Assia Shisheva; Anders A F Sima
Molecular basis for the insulinomimetic effects of C-peptide.
Diabetologia 2001;44(10):1247-57.
2001: Ognian C Ikonomov; Diego Sbrissa; Assia Shisheva
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve.
The Journal of biological chemistry 2001;276(28):26141-7.
2001: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
Selective insulin-induced activation of class I(A) phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes.
Molecular and cellular endocrinology 2001;181(1-2):35-46.
2001: Assia Shisheva; B Rusin; Ognian C Ikonomov; Carmen E DeMarco; Diego Sbrissa
Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes.
The Journal of biological chemistry 2001;276(15):11859-69.
2001: Assia Shisheva
PIKfyve: the road to PtdIns 5-P and PtdIns 3,5-P(2).
Cell biology international 2001;25(12):1201-6.
2001: Assia Shisheva
Antibody and oligonucleotide probes to distinguish intracellular expression and localization patterns of Rab GDP-dissociation inhibitor isoforms.
Methods in enzymology 2001;329():39-50.
2000: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation.
Biochemistry 2000;39(51):15980-9.
2000: Ognian C Ikonomov; Theodor Petrov; K Soden; Assia Shisheva; Husseini K Manji
Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO.
Brain research. Developmental brain research 2000;123(1):13-24.
1999: Robert K McEwen; Stephen K Dove; Frank T Cooke; GF Painter; Andrew B Holmes; Assia Shisheva; Y Ohya; Peter J Parker; Robert H Michell
Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.
The Journal of biological chemistry 1999;274(48):33905-12.
1999: Assia Shisheva; Sreenivasa R Chinni; Carmen E DeMarco
General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications.
Biochemistry 1999;38(36):11711-21.
1999: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin.
The Journal of biological chemistry 1999;274(31):21589-97.
1999: Sreenivasa R Chinni; Assia Shisheva
Arrest of endosome acidification by bafilomycin A1 mimics insulin action on GLUT4 translocation in 3T3-L1 adipocytes.
The Biochemical journal 1999;339 ( Pt 3)():599-606.
1999: Ognian C Ikonomov; Assia Shisheva; AG Stoynev
Circadian clocks and hypertension: genetics and interactions.
Acta physiologica et pharmacologica Bulgarica 1999;24(3):65-70.
1999: Assia Shisheva; Diego Sbrissa; Ognian C Ikonomov
Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells.
Molecular and cellular biology 1999;19(1):623-34.
1998: Ognian C Ikonomov; M C Kulesa; Assia Shisheva; M H Jacob
Innervation and target tissue interactions induce Rab-GDP dissociation inhibitor (GDI) expression during peripheral synapse formation in developing chick ciliary ganglion neurons in situ.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(16):6331-9.
1998: Sreenivasa R Chinni; M Brenz; Assia Shisheva
Modulation of GDP-dissociation inhibitor protein membrane retention by the cellular redox state in adipocytes.
Experimental cell research 1998;242(1):373-80.
1998: Ognian C Ikonomov; AG Stoynev; Assia Shisheva
Integrative coordination of circadian mammalian diversity: neuronal networks and peripheral clocks.
Progress in neurobiology 1998;54(1):87-97.
1997: Assia Shisheva; M P Czech
Association of cytosolic Rab4 with GDI isoforms in insulin-sensitive 3T3-L1 adipocytes.
Biochemistry 1997;36(22):6564-70.
1995: Yoram Shechter; J Li; J Meyerovitch; D Gefel; Rafael Bruck; G Elberg; D S Miller; Assia Shisheva
Insulin-like actions of vanadate are mediated in an insulin-receptor-independent manner via non-receptor protein tyrosine kinases and protein phosphotyrosine phosphatases.
Molecular and cellular biochemistry 1995;153(1-2):39-47.
1995: Assia Shisheva; Stephen J Doxsey; JM Buxton; Michael P Czech
Pericentriolar targeting of GDP-dissociation inhibitor isoform 2.
European journal of cell biology 1995;68(2):143-58.
1994: Assia Shisheva; JM Buxton; Michael P Czech
Differential intracellular localizations of GDP dissociation inhibitor isoforms. Insulin-dependent redistribution of GDP dissociation inhibitor-2 in 3T3-L1 adipocytes.
The Journal of biological chemistry 1994;269(39):23865-8.
1994: Assia Shisheva; T C Südhof; Michael P Czech
Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.
Molecular and cellular biology 1994;14(5):3459-68.
1994: Assia Shisheva; Yoram Shechter
A dynamic system for suppression and re-expression of insulin and pervanadate bioresponses in rat adipocytes. Treatment with okadaic acid and staurosporine.
Biochemical pharmacology 1994;47(9):1537-44.
1994: Assia Shisheva; Ognian C Ikonomov; Yoram Shechter
The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats.
Endocrinology 1994;134(1):507-10.
1994: Ognian C Ikonomov; AG Stoynev; Assia Shisheva
Circadian function of suprachiasmatic nuclei: molecular and cellular biology.
Chronobiologia 1994;21(1-2):71-7.
1993: Assia Shisheva; Yoram Shechter
Mechanism of pervanadate stimulation and potentiation of insulin-activated glucose transport in rat adipocytes: dissociation from vanadate effect.
Endocrinology 1993;133(4):1562-8.
1993: Assia Shisheva; Yoram Shechter
Role of cytosolic tyrosine kinase in mediating insulin-like actions of vanadate in rat adipocytes.
The Journal of biological chemistry 1993;268(9):6463-9.
1993: Yoram Shechter; Assia Shisheva
Vanadium salts and the future treatment of diabetes.
Endeavour 1993;17(1):27-31.
1992: Assia Shisheva; Yoram Shechter
Quercetin selectively inhibits insulin receptor function in vitro and the bioresponses of insulin and insulinomimetic agents in rat adipocytes.
Biochemistry 1992;31(34):8059-63.
1992: Assia Shisheva; D Gefel; Yoram Shechter
Insulinlike effects of zinc ion in vitro and in vivo. Preferential effects on desensitized adipocytes and induction of normoglycemia in streptozocin-induced rats.
Diabetes 1992;41(8):982-8.
1992: Assia Shisheva; Yoram Shechter
A cytosolic protein tyrosine kinase in rat adipocytes.
FEBS letters 1992;300(1):93-6.
1992: E Hazum; Assia Shisheva; Y Shechter
Preparation and application of radioiodinated sulfhydryl reagents for the covalent labeling of SH-proteins present in minute quantities.
Journal of biochemical and biophysical methods 1992;24(1-2):95-106.
1992: Yoram Shechter; Assia Shisheva; R Lazar; J Libman; Abraham Shanzer
Hydrophobic carriers of vanadyl ions augment the insulinomimetic actions of vanadyl ions in rat adipocytes.
Biochemistry 1992;31(7):2063-8.
1991: Assia Shisheva; O Leitner; Yoram Shechter
A novel approach for evaluating tyrosine kinase activity based on the radioimmunological determination of phosphotyrosine.
Journal of biochemical and biophysical methods 1991;23(4):307-14.
1991: Assia Shisheva; Yoram Shechter
Effect of okadaic acid in rat adipocytes: differential stimulation of glucose and lipid metabolism and induction of refractoriness to insulin and vanadate.
Endocrinology 1991;129(5):2279-88.
1991: Ognian C Ikonomov; Assia Shisheva; AG Stoynev; I V Kurtev
Peripheral p-chloroamphetamine is an unsuitable probe for investigation of central serotoninergic control on renal renin secretion in the rat.
Physiology & behavior 1991;49(6):1119-28.
1991: Assia Shisheva; T Dimitrov; Ognian C Ikonomov
Plasma angiotensin-converting enzyme activity and blood pressure during the first year of life in normotensive and spontaneously hypertensive rat.
Acta physiologica Hungarica 1991;77(2):129-38.
1990: Assia Shisheva; A Stoĭnev; Ognian C Ikonomov
[A method for determining the angiotensin-converting enzyme activity in the rat hypothalamus and hypophysis].
Eksperimentalna meditsina i morfologiia 1990;29(2):33-41.
1987: Assia Shisheva; Ognian C Ikonomov; AG Stoynev; J Popova
Renin release and water-salt balance after central serotonin depletion by p-chlorophenylalanine in Brattleboro and Wistar rats: possible role of ADH.
Endocrinologia experimentalis 1987;21(3):219-28.
1986: Ognian C Ikonomov; Assia Shisheva; AG Stoynev; I V Kurtev
Effect on the plasma renin-aldosterone system of lesions to suprachiasmatic nuclei and central serotonin depletion in rats.
Acta physiologica Hungarica 1986;68(2):211-9.
1985: Ognian C Ikonomov; AG Stoynev; Assia Shisheva; N T Tarkolev
Effect of constant light and darkness on the circadian rhythms in rats. II. Plasma renin activity and insulin concentration.
Acta physiologica et pharmacologica Bulgarica 1985;11(1):55-61.
1985: Ognian C Ikonomov; AG Stoynev; N C Vrabchev; Assia Shisheva; N T Tarkolev
Circadian rhythms of food and 1% NaCl intake, urine and electrolyte excretion, plasma renin activity and insulin concentration in adrenalectomized rats.
Acta physiologica Hungarica 1985;65(2):181-98.
1981: Ognian C Ikonomov; AG Stoynev; Assia Shisheva; N Tarkolev
[Circadian rhythms of plasma renin activity and the plasma concentration of aldosterone and insulin in the rat: effect of renal denervation and food restriction].
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression 1981;22(6):247-53.
1980: AG Stoynev; Ognian C Ikonomov; N Tarkolev; Assia Shisheva
Effects of suprachiasmatic nuclei (SCN) lesions on the circadian variations in PRA and IRI level in the rat.
Acta physiologica Academiae Scientiarum Hungaricae 1980;56(4):431-5.