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Peter Blumberg
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58
Lewin, Nancy
51
Marquez, Victor
39
Lee, Jeewoo
25
Acs, Peter
23
Kazanietz, Marcelo
23
Pearce, Larry
23
Szallasi, Arpad
22
Pettit, George
21
Kedei, Noemi
18
Garfield, Susan
18
Toth, Attila
17
Lorenzo, Patricia
15
Brodie, Chaya
14
Bíró, Tamás
14
Tran, Richard
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All Publications
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2009: Sosa Maria Soledad; Lewin Nancy E; Choi Sung-Hee; Blumberg Peter M; Kazanietz Marcelo G
Biochemical characterization of hyperactive beta2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains.
Biochemistry 2009;48(34):8171-8.
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2009: Keck Gary E; Li Wei; Kraft Matthew B; Kedei Noemi; Lewin Nancy E; Blumberg Peter M
The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.
Organic letters 2009;11(11):2277-80.
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2009: Comin Maria J; Czifra Gabriella; Kedei Noemi; Telek Andrea; Lewin Nancy E; Kolusheva Sofiya; Velasquez Julia F; Kobylarz Ryan; Jelinek Raz; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
Journal of medicinal chemistry 2009;52(10):3274-83.
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2009: Keck Gary E; Poudel Yam B; Welch Dennie S; Kraft Matthew B; Truong Anh P; Stephens Jeffrey C; Kedei Noemi; Lewin Nancy E; Blumberg Peter M
Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters.
Organic letters 2009;11(3):593-6.
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2009: Szegedi Andrea; Páyer Edit; Czifra Gabriella; Tóth Balázs I; Schmidt Emese; Kovács László; Blumberg Peter M; Bíró Tamás
Protein kinase C isoenzymes differentially regulate the differentiation-dependent expression of adhesion molecules in human epidermal keratinocytes.
Experimental dermatology 2009;18(2):122-9.
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2009: Choi Hyun-Kyung; Choi Sun; Lee Yoonji; Kang Dong Wook; Ryu HyungChul; Maeng Han-Joo; Chung Suk-Jae; Pavlyukovets Vladimir A; Pearce Larry V; Toth Attila; Tran Richard; Wang Yun; Morgan Matthew A; Blumberg Peter M; Lee Jeewoo
Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists.
Bioorganic & medicinal chemistry 2009;17(2):690-8.
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2009: Pu Yongmei; Garfield Susan H; Kedei Noemi; Blumberg Peter M
Characterization of the differential roles of the twin C1a and C1b domains of protein kinase C-delta.
The Journal of biological chemistry 2009;284(2):1302-12.
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2009: Lim Ju-Ok; Jin Mi-Kyoung; Ryu HyungChul; Kang Dong Wook; Lee Jeewoo; Pearce Larry V; Tran Richard; Toth Attila; Blumberg Peter M
Conformationally constrained analogues of N'-(4-tert-butylbenzyl)-N-(4-methylsulfonylaminobenzyl)thiourea as TRPV1 antagonists.
European journal of medicinal chemistry 2009;44(1):322-31.
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2009: Tóth Attila; Blumberg Peter M; Boczán Judit
Anandamide and the vanilloid receptor (TRPV1).
Vitamins and hormones 2009;81():389-419.
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2008: Philosof-Mazor Liron; Volinsky Roman; Comin Maria J; Lewin Nancy E; Kedei Noemi; Blumberg Peter M; Marquez Victor E; Jelinek Raz
Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface.
Langmuir : the ACS journal of surfaces and colloids 2008;24(19):11043-52.
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2008: Duan Dehui; Sigano Dina M; Kelley James A; Lai Christopher C; Lewin Nancy E; Kedei Noemi; Peach Megan L; Lee Jeewoo; Abeyweera Thushara P; Rotenberg Susan A; Kim Hee; Kim Young Ho; El Kazzouli Saïd; Chung Jae-Uk; Young Howard A; Young Matthew R; Baker Alyson; Colburn Nancy H; Haimovitz-Friedman Adriana; Truman Jean-Philip; Parrish Damon A; Deschamps Jeffrey R; Perry Nicholas A; Surawski Robert J; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.
Journal of medicinal chemistry 2008;51(17):5198-220.
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2008: Blumberg P M; Kedei N; Lewin N E; Yang D; Czifra G; Pu Y; Peach M L; Marquez V E
Wealth of opportunity - the C1 domain as a target for drug development.
Current drug targets 2008;9(8):641-52.
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2008: Gönczi Mónika; Telek Andrea; Czifra Gabriella; Balogh Attila; Blumberg Peter M; Bíró Tamás; Csernoch László
Altered calcium handling following the recombinant overexpression of protein kinase C isoforms in HaCaT cells.
Experimental dermatology 2008;17(7):584-91.
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2008: Lomonaco Stephanie L; Kahana Sarit; Blass Michal; Brody Yehuda; Okhrimenko Hana; Xiang Cunli; Finniss Susan; Blumberg Peter M; Lee Hae-Kyung; Brodie Chaya
Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide.
The Journal of biological chemistry 2008;283(25):17731-9.
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2008: Keck Gary E; Kraft Matthew B; Truong Anh P; Li Wei; Sanchez Carina C; Kedei Noemi; Lewin Nancy E; Blumberg Peter M
Convergent assembly of highly potent analogues of bryostatin 1 via pyran annulation: bryostatin look-alikes that mimic phorbol ester function.
Journal of the American Chemical Society 2008;130(21):6660-1.
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2008: Choi Sung Hee; Czifra Gabriella; Kedei Noemi; Lewin Nancy E; Lazar Jozsef; Pu Yongmei; Marquez Victor E; Blumberg Peter M
Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta.
The Journal of biological chemistry 2008;283(16):10543-9.
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2008: Pearce Larry V; Toth Attila; Ryu HyungChul; Kang Dong Wook; Choi Hyun-Kyung; Jin Mi-Kyoung; Lee Jeewoo; Blumberg Peter M
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors.
Naunyn-Schmiedeberg's archives of pharmacology 2008;377(2):149-57.
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2008: Ryu HyungChul; Jin Mi-Kyoung; Kim Su Yeon; Choi Hyun-Kyung; Kang Sang-Uk; Kang Dong Wook; Lee Jeewoo; Pearce Larry V; Pavlyukovets Vladimir A; Morgan Matthew A; Tran Richard; Toth Attila; Lundberg Daniel J; Blumberg Peter M
Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues.
Journal of medicinal chemistry 2008;51(1):57-67.
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2007: Blumberg Peter M
Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1.
Molecular interventions 2007;7(6):310-2.
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2007: Chung Jae-Uk; Kim Su Yeon; Lim Ju-Ok; Choi Hyun-Kyung; Kang Sang-Uk; Yoon Hae-Seok; Ryu Hyungchul; Kang Dong Wook; Lee Jeewoo; Kang Bomi; Choi Sun; Toth Attila; Pearce Larry V; Pavlyukovets Vladimir A; Lundberg Daniel J; Blumberg Peter M
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists.
Bioorganic & medicinal chemistry 2007;15(18):6043-53.
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2007: Choi Yongseok; Pu Yongmei; Peach Megan L; Kang Ji-Hye; Lewin Nancy E; Sigano Dina M; Garfield Susan H; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.
Journal of medicinal chemistry 2007;50(15):3465-81.
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2007: Malolanarasimhan Krishnan; Kedei Noemi; Sigano Dina M; Kelley James A; Lai Christopher C; Lewin Nancy E; Surawski Robert J; Pavlyukovets Vladimir A; Garfield Susan H; Wincovitch Stephen; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 27. Modulation of membrane translocation of protein kinase C (PKC) isozymes alpha and delta by diacylglycerol lactones (DAG-lactones) containing rigid-rod acyl groups.
Journal of medicinal chemistry 2007;50(5):962-78.
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2007: Kang Dong Wook; Ryu Hyungchul; Lee Jeewoo; Lang Krystle A; Pavlyukovets Vladimir A; Pearce Larry V; Ikeda Tetsurou; Lazar Jozsef; Blumberg Peter M
Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin.
Bioorganic & medicinal chemistry letters 2007;17(1):214-9.
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2006: Pu Yongmei; Peach Megan L; Garfield Susan H; Wincovitch Stephen; Marquez Victor E; Blumberg Peter M
Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms.
The Journal of biological chemistry 2006;281(44):33773-88.
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2006: Czifra Gabriella; Tóth István Balázs; Marincsák Rita; Juhász István; Kovács Ilona; Acs Péter; Kovács László; Blumberg Peter M; Bíró Tamás
Insulin-like growth factor-I-coupled mitogenic signaling in primary cultured human skeletal muscle cells and in C2C12 myoblasts. A central role of protein kinase Cdelta.
Cellular signalling 2006;18(9):1461-72.
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2006: Choi Sung Hee; Hyman Tehila; Blumberg Peter M
Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta.
Cancer research 2006;66(14):7261-9.
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2006: Kang Ji-Hye; Benzaria Samira; Sigano Dina M; Lewin Nancy E; Pu Yongmei; Peach Megan L; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.
Journal of medicinal chemistry 2006;49(11):3185-203.
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2006: Lazar Jozsef; Braun Derek C; Tóth Attila; Wang Yun; Pearce Larry V; Pavlyukovets Vladimir A; Blumberg Peter M; Garfield Susan H; Wincovitch Stephen; Choi Hyun-Kyung; Lee Jeewoo
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1.
Molecular pharmacology 2006;69(4):1166-73.
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2006: Lee Jeewoo; Kang Ji-Hye; Han Kee-Chung; Kim Yerim; Kim Su Yeon; Youn Hae-Suk; Mook-Jung Inhee; Kim Hee; Lo Han Jee Hye; Ha Hee Jin; Kim Young Ho; Marquez Victor E; Lewin Nancy E; Pearce Larry V; Lundberg Daniel J; Blumberg Peter M
Branched diacylglycerol-lactones as potent protein kinase C ligands and alpha-secretase activators.
Journal of medicinal chemistry 2006;49(6):2028-36.
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2006: Lizanecz Erzsébet; Bagi Zsolt; Pásztor Eniko T; Papp Zoltán; Edes István; Kedei Noémi; Blumberg Peter M; Tóth Attila
Phosphorylation-dependent desensitization by anandamide of vanilloid receptor-1 (TRPV1) function in rat skeletal muscle arterioles and in Chinese hamster ovary cells expressing TRPV1.
Molecular pharmacology 2006;69(3):1015-23.
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2006: Lee Jeewoo; Lee Ju-Hyun; Kim Su Yeon; Perry Nicholas A; Lewin Nancy E; Ayres Jolene A; Blumberg Peter M
2-Benzyl and 2-phenyl-3-hydroxypropyl pivalates as protein kinase C ligands.
Bioorganic & medicinal chemistry 2006;14(6):2022-31.
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2005: Kang Ji-Hye; Peach Megan L; Pu Yongmei; Lewin Nancy E; Nicklaus Marc C; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 25. Exploration of the sn-1 and sn-2 carbonyl functionality reveals the essential role of the sn-1 carbonyl at the lipid interface in the binding of DAG-lactones to protein kinase C.
Journal of medicinal chemistry 2005;48(18):5738-48.
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2005: Lee Jeewoo; Kang Sang-Uk; Kil Min-Jung; Shin Myoungyoup; Lim Ju-Ok; Choi Hyun-Kyung; Jin Mi-Kyoung; Kim Su Yeon; Kim Sung-Eun; Lee Yong-Sil; Min Kyung-Hoon; Kim Young-Ho; Ha Hee-Jin; Tran Richard; Welter Jacqueline D; Wang Yun; Szabo Tamas; Pearce Larry V; Lundberg Daniel J; Toth Attila; Pavlyukovets Vladimir A; Morgan Matthew A; Blumberg Peter M
Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(18):4136-42.
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2005: Lee Jeewoo; Jin Mi-Kyoung; Kang Sang-Uk; Kim Su Yeon; Lee Jiyoun; Shin Myoungyoup; Hwang Jaemin; Cho Sookhyun; Choi Yeon-Sil; Choi Hyun-Kyung; Kim Sung-Eun; Suh Young-Ger; Lee Yong-Sil; Kim Young-Ho; Ha Hee-Jin; Toth Attila; Pearce Larry V; Tran Richard; Szabo Tamas; Welter Jacqueline D; Lundberg Daniel J; Wang Yun; Lazar Jozsef; Pavlyukovets Vladimir A; Morgan Matthew A; Blumberg Peter M
Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists.
Bioorganic & medicinal chemistry letters 2005;15(18):4143-50.
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2005: Qiang Ya-Wei; Walsh Katie; Yao Lei; Kedei Noemi; Blumberg Peter M; Rubin Jeffrey S; Shaughnessy John; Rudikoff Stuart
Wnts induce migration and invasion of myeloma plasma cells.
Blood 2005;106(5):1786-93.
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2005: Pu Yongmei; Perry Nicholas A; Yang Dazhi; Lewin Nancy E; Kedei Noemi; Braun Derek C; Choi Sung Hee; Blumberg Peter M; Garfield Susan H; Stone James C; Duan Dehui; Marquez Victor E
A novel diacylglycerol-lactone shows marked selectivity in vitro among C1 domains of protein kinase C (PKC) isoforms alpha and delta as well as selectivity for RasGRP compared with PKCalpha.
The Journal of biological chemistry 2005;280(29):27329-38.
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2005: Okhrimenko Hana; Lu Wei; Xiang Cunli; Ju Donghong; Blumberg Peter M; Gomel Ruth; Kazimirsky Gila; Brodie Chaya
Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis.
The Journal of biological chemistry 2005;280(25):23643-52.
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2005: Tóth Attila; Wang Yun; Kedei Noémi; Tran Richard; Pearce Larry V; Kang Sang-Uk; Jin Mi-Kyung; Choi Hyun-Kyung; Lee Jeewoo; Blumberg Peter M
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1.
Life sciences 2005;76(25):2921-32.
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2005: Tóth Attila; Boczán Judit; Kedei Noémi; Lizanecz Erzsébet; Bagi Zsolt; Papp Zoltán; Edes István; Csiba László; Blumberg Peter M
Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain.
Brain research. Molecular brain research 2005;135(1-2):162-8.
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2005: Braun Derek C; Garfield Susan H; Blumberg Peter M
Analysis by fluorescence resonance energy transfer of the interaction between ligands and protein kinase Cdelta in the intact cell.
The Journal of biological chemistry 2005;280(9):8164-71.
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2005: Braun Derek C; Cao Yeyu; Wang Shaomeng; Garfield Susan H; Hur Gang Min; Blumberg Peter M
Role of phorbol ester localization in determining protein kinase C or RasGRP3 translocation: real-time analysis using fluorescent ligands and proteins.
Molecular cancer therapeutics 2005;4(1):141-50.
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2004: Wang Yun; Kedei Noemi; Wang Min; Wang Q Jane; Huppler Anna R; Toth Attila; Tran Richard; Blumberg Peter M
Interaction between protein kinase Cmu and the vanilloid receptor type 1.
The Journal of biological chemistry 2004;279(51):53674-82.
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2004: Tamamura Hirokazu; Sigano Dina M; Lewin Nancy E; Peach Megan L; Nicklaus Marc C; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C).
Journal of medicinal chemistry 2004;47(20):4858-64.
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2004: Pearce Larry V; Petukhov Pavel A; Szabo Tamas; Kedei Noemi; Bizik Fero; Kozikowski Alan P; Blumberg Peter M
Evodiamine functions as an agonist for the vanilloid receptor TRPV1.
Organic & biomolecular chemistry 2004;2(16):2281-6.
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2004: Kang Ji-Hye; Kim Su Yeon; Lee Jeewoo; Marquez Victor E; Lewin Nancy E; Pearce Larry V; Blumberg Peter M
Macrocyclic diacylglycerol-bis-lactones as conformationally constrained analogues of diacylglycerol-lactones. Interactions with protein kinase C.
Journal of medicinal chemistry 2004;47(16):4000-7.
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2004: Kang Ji-Hye; Siddiqui Maqbool A; Sigano Dina M; Krajewski Krzysztof; Lewin Nancy E; Pu Yongmei; Blumberg Peter M; Lee Jeewoo; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones.
Organic letters 2004;6(14):2413-6.
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2004: Brodie Chaya; Steinhart Rivka; Kazimirsky Gila; Rubinfeld Hadara; Hyman Tehila; Ayres Jolene N; Hur Gang Min; Toth Attila; Yang Dazhi; Garfield Susan H; Stone James C; Blumberg Peter M
PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.
Molecular pharmacology 2004;66(1):76-84.
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2004: Lee Jeewoo; Kim Su Yeon; Lee Jiyoun; Kang Myungsim; Kil Min-Jung; Choi Hyun-Kyung; Jin Mi-Kyung; Wang Yun; Toth Attila; Pearce Larry V; Lundberg Daniel J; Tran Richard; Blumberg Peter M
Analysis of structure-activity relationships with the N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea template for vanilloid receptor 1 antagonism.
Bioorganic & medicinal chemistry 2004;12(13):3411-20.
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2004: Duan Dehui; Lewin Nancy E; Sigano Dina M; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.
Journal of medicinal chemistry 2004;47(12):3248-54.
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2004: Kedei Noemi; Lundberg Daniel J; Toth Attila; Welburn Peter; Garfield Susan H; Blumberg Peter M
Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Cancer research 2004;64(9):3243-55.
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2004: Lázár József; Szabó Tamás; Marincsák Rita; Kovács László; Blumberg Peter M; Bíró Tamás
Sensitization of recombinant vanilloid receptor-1 by various neurotrophic factors.
Life sciences 2004;75(2):153-63.
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2004: Papp H; Czifra G; Bodó E; Lázár J; Kovács I; Aleksza M; Juhász I; Acs P; Sipka S; Kovács L; Blumberg P M; Bíró T
Opposite roles of protein kinase C isoforms in proliferation, differentiation, apoptosis, and tumorigenicity of human HaCaT keratinocytes.
Cellular and molecular life sciences : CMLS 2004;61(9):1095-105.
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2004: Lee Jeewoo; Kang Sang-Uk; Choi Hyun-Kyung; Lee Jiyoun; Lim Ju-Ok; Kil Min-Jung; Jin Mi-Kyung; Kim Kang-Pil; Sung Jong-Hyuk; Chung Suk-Jae; Ha Hee-Jin; Kim Young-Ho; Pearce Larry V; Tran Richard; Lundberg Daniel J; Wang Yun; Toth Attila; Blumberg Peter M
Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.
Bioorganic & medicinal chemistry letters 2004;14(9):2291-7.
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2004: Gavva Narender R; Klionsky Lana; Qu Yusheng; Shi Licheng; Tamir Rami; Edenson Steve; Zhang T J; Viswanadhan Vellarkad N; Toth Attila; Pearce Larry V; Vanderah Todd W; Porreca Frank; Blumberg Peter M; Lile Jack; Sun Yax; Wild Ken; Louis Jean-Claude; Treanor James J S
Molecular determinants of vanilloid sensitivity in TRPV1.
The Journal of biological chemistry 2004;279(19):20283-95.
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2004: Pettit George R; Hoffmann Holger; Herald Delbert L; McNulty James; Murphy Alison; Higgs Kerianne C; Hamel Ernest; Lewin Nancy E; Pearce Larry V; Blumberg Peter M; Pettit Robin K; Knight John C
Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine.
The Journal of organic chemistry 2004;69(7):2251-6.
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2004: Pettit George R; Hoffmann Holger; Herald Delbert L; Blumberg Peter M; Hamel Ernest; Schmidt Jean M; Chang Yung; Pettit Robin K; Lewin Nancy E; Pearce Larry V
Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine.
Journal of medicinal chemistry 2004;47(7):1775-82.
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2004: Lee Jeewoo; Kim Su Yeon; Park Soyoung; Lim Ju-Ok; Kim Ji-Min; Kang Myungshim; Lee Jiyoun; Kang Sang-Uk; Choi Hyun-Kyung; Jin Mi-Kyung; Welter Jacqueline D; Szabo Tamas; Tran Richard; Pearce Larry V; Toth Attila; Blumberg Peter M
Structure-activity relationships of simplified resiniferatoxin analogues with potent VR1 agonism elucidates an active conformation of RTX for VR1 binding.
Bioorganic & medicinal chemistry 2004;12(5):1055-69.
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2004: Wang Qiming Jane; Lu Ganwei; Schlapkohl Walter A; Goerke Axel; Larsson Christer; Mischak Harald; Blumberg Peter M; Mushinski J Frederic
The V5 domain of protein kinase C plays a critical role in determining the isoform-specific localization, translocation, and biological function of protein kinase C-delta and -epsilon.
Molecular cancer research : MCR 2004;2(2):129-40.
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2004: Tóth Attila; Blumberg Peter M; Chen Zili; Kozikowski Alan P
Design of a high-affinity competitive antagonist of the vanilloid receptor selective for the calcium entry-linked receptor population.
Molecular pharmacology 2004;65(2):282-91.
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2004: Lee Jeewoo; Kim Su Yeon; Kang Ji-Hye; Acs Geza; Acs Peter; Blumberg Peter M; Marquez Victor E
Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands.
European journal of medicinal chemistry 2004;39(1):69-77.
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2004: Tamamura Hirokazu; Sigano Dina M; Lewin Nancy E; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C through relocation of the carbonyl pharmacophore along the sn-1 side chain of 1,2-diacylglycerol lactones.
Journal of medicinal chemistry 2004;47(3):644-55.
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2004: Lee Jeewoo; Kang Sang-Uk; Lim Ju-Ok; Choi Hyun-Kyung; Jin Mi-kyung; Toth Attila; Pearce Larry V; Tran Richard; Wang Yun; Szabo Tamas; Blumberg Peter M
N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: analysis of structure-activity relationships for the "C-Region".
Bioorganic & medicinal chemistry 2004;12(2):371-85.
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2003: Wang Qiming J; Fang Tzan-Wei; Yang Dazhi; Lewin Nancy E; Van Lint Johan; Marquez Victor E; Blumberg Peter M
Ligand structure-activity requirements and phospholipid dependence for the binding of phorbol esters to protein kinase D.
Molecular pharmacology 2003;64(6):1342-8.
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2003: Rambaratsingh Reshmi A; Stone James C; Blumberg Peter M; Lorenzo Patricia S
RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.
The Journal of biological chemistry 2003;278(52):52792-801.
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2003: Lázár J; Szabó T; Kovács L; Blumberg P M; Bíró T
Distinct features of recombinant rat vanilloid receptor-1 expressed in various expression systems.
Cellular and molecular life sciences : CMLS 2003;60(10):2228-40.
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2003: Hamer Dean H; Bocklandt Sven; McHugh Louise; Chun Tae-Wook; Blumberg Peter M; Sigano Dina M; Marquez Victor E
Rational design of drugs that induce human immunodeficiency virus replication.
Journal of virology 2003;77(19):10227-36.
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2003: Sridhar Jayalakshmi; Wei Zhi-Liang; Nowak Ireneusz; Lewin Nancy E; Ayres Jolene A; Pearce Larry V; Blumberg Peter M; Kozikowski Alan P
New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity.
Journal of medicinal chemistry 2003;46(19):4196-204.
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2003: Wang Yun; Toth Attila; Tran Richard; Szabo Tamas; Welter Jacqueline D; Blumberg Peter M; Lee Jiyoun; Kang Sang-Uk; Lim Ju-Ok; Lee Jeewoo
High-affinity partial agonists of the vanilloid receptor.
Molecular pharmacology 2003;64(2):325-33.
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2003: Bocklandt Sven; Blumberg Peter M; Hamer Dean H
Activation of latent HIV-1 expression by the potent anti-tumor promoter 12-deoxyphorbol 13-phenylacetate.
Antiviral research 2003;59(2):89-98.
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2003: Lee Jeewoo; Lee Jiyoun; Kang Myungshim; Shin Myoungyoup; Kim Ji-Min; Kang Sang-Uk; Lim Ju-Ok; Choi Hyun-Kyung; Suh Young-Ger; Park Hyeung-Geun; Oh Uhtaek; Kim Hee-Doo; Park Young-Ho; Ha Hee-Jin; Kim Young-Ho; Toth Attila; Wang Yun; Tran Richard; Pearce Larry V; Lundberg Daniel J; Blumberg Peter M
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
Journal of medicinal chemistry 2003;46(14):3116-26.
-
2003: Hyman Tehila; Huizing Marjan; Blumberg Peter M; Falik-Zaccai Tzipora C; Anikster Yair; Gahl William A
Use of a cDNA microarray to determine molecular mechanisms involved in grey platelet syndrome.
British journal of haematology 2003;122(1):142-9.
-
2003: Marquez Victor E; Blumberg Peter M
Synthetic diacylglycerols (DAG) and DAG-lactones as activators of protein kinase C (PK-C).
Accounts of chemical research 2003;36(6):434-43.
-
2003: Choi Yongseok; Kang Ji-Hye; Lewin Nancy E; Blumberg Peter M; Lee Jeewoo; Marquez Victor E
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain.
Journal of medicinal chemistry 2003;46(13):2790-3.
-
2003: Tóth Attila; Kedei Noémi; Wang Yun; Blumberg Peter M
Arachidonyl dopamine as a ligand for the vanilloid receptor VR1 of the rat.
Life sciences 2003;73(4):487-98.
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2003: Kang Ji-Hye; Chung Hye-Eun; Kim Su Yeon; Kim Yerim; Lee Jeewoo; Lewin Nancy E; Pearce Larry V; Blumberg Peter M; Marquez Victor E
Conformationally constrained analogues of diacylglycerol (DAG). Effect on protein kinase C (PK-C) binding by the isosteric replacement of sn-1 and sn-2 esters in DAG-lactones.
Bioorganic & medicinal chemistry 2003;11(12):2529-39.
-
2003: Sigano Dina M; Peach Megan L; Nacro Kassoum; Choi Yongseok; Lewin Nancy E; Nicklaus Marc C; Blumberg Peter M; Marquez Victor E
Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
Journal of medicinal chemistry 2003;46(9):1571-9.
-
2003: Clark Amy S; West Kip A; Blumberg Peter M; Dennis Phillip A
Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance.
Cancer research 2003;63(4):780-6.
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2003: Kozikowski Alan P; Nowak Ireneusz; Petukhov Pavel A; Etcheberrigaray Rene; Mohamed Ali; Tan Mathew; Lewin Nancy; Hennings Henry; Pearce Larry L; Blumberg Peter M
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha.
Journal of medicinal chemistry 2003;46(3):364-73.
-
2003: Brodie C; Blumberg P M
Regulation of cell apoptosis by protein kinase c delta.
Apoptosis : an international journal on programmed cell death 2003;8(1):19-27.
-
2003: Lewin Nancy E; Blumberg Peter M
[3H]Phorbol 12,13-dibutyrate binding assay for protein kinase C and related proteins.
Methods in molecular biology (Clifton, N.J.) 2003;233():129-56.
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2002: Wang Yun; Szabo Tamas; Welter Jacqueline D; Toth Attila; Tran Richard; Lee Jiyoun; Kang Sang Uk; Suh Young-Ger; Blumberg Peter M; Lee Jeewoo
High affinity antagonists of the vanilloid receptor.
Molecular pharmacology 2002;62(4):947-56.
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2002: Pettit George R; Ducki Sylvie; Tan Rui; Gardella Roberta S; McMahon James B; Boyd Michael R; Pettit George R; Blumberg Peter M; Lewin Nancy E; Doubek Dennis L; Tackett Larry P; Williams Michael D
Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp.
Journal of natural products 2002;65(9):1262-5.
-
2002: Di Marzo Vincenzo; Blumberg Peter M; Szallasi Arpad
Endovanilloid signaling in pain.
Current opinion in neurobiology 2002;12(4):372-9.
-
2002: Wei Zhi-Liang; Sakamuri Sukumar; Petukhov Pavel A; George Clifford; Lewin Nancy E; Blumberg Peter M; Kozikowski Alan P
Synthesis and modeling study of (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy- 8-(1-decynyl)-benzolactam-V8 as protein kinase C modulators.
Organic letters 2002;4(13):2169-72.
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2002: Zrachia Avi; Dobroslav Melamed; Blass Michal; Kazimirsky Gila; Kronfeld Ilana; Blumberg Peter M; Kobiler David; Lustig Shlomo; Brodie Chaya
Infection of glioma cells with Sindbis virus induces selective activation and tyrosine phosphorylation of protein kinase C delta. Implications for Sindbis virus-induced apoptosis.
The Journal of biological chemistry 2002;277(26):23693-701.
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2002: Tóth Attila; Kedei Noémi; Szabó Tamás; Wang Yun; Blumberg Peter M
Thapsigargin binds to and inhibits the cloned vanilloid receptor-1.
Biochemical and biophysical research communications 2002;293(2):777-82.
-
2002: Lee Jeewoo; Lee Jiyoun; Kang Myung-Sim; Kim Kang-Pil; Chung Suk-Jae; Blumberg Peter M; Yi Jung-Bum; Park Young Ho
Phenolic modification as an approach to improve the pharmacology of the 3-acyloxy-2-benzylpropyl homovanillic amides and thioureas, a promising class of vanilloid receptor agonists and analgesics.
Bioorganic & medicinal chemistry 2002;10(4):1171-9.
-
2002: Joseloff Elizabeth; Cataisson Christophe; Aamodt Heather; Ocheni Henrietta; Blumberg Peter; Kraker Alan J; Yuspa Stuart H
Src family kinases phosphorylate protein kinase C delta on tyrosine residues and modify the neoplastic phenotype of skin keratinocytes.
The Journal of biological chemistry 2002;277(14):12318-23.
-
2002: Rong Suo-Bao; Enyedy Istvan J; Qiao Lixin; Zhao Lianyun; Ma Dawei; Pearce Larry L; Lorenzo Patricia S; Stone James C; Blumberg Peter M; Wang Shaomeng; Kozikowski Alan P
Structural basis of RasGRP binding to high-affinity PKC ligands.
Journal of medicinal chemistry 2002;45(4):853-60.
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2002: Szabo Tamas; Biro Tamas; Gonzalez Adamar F; Palkovits Miklos; Blumberg Peter M
Pharmacological characterization of vanilloid receptor located in the brain.
Brain research. Molecular brain research 2002;98(1-2):51-7.
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2002: Blass Michal; Kronfeld Ilana; Kazimirsky Gila; Blumberg Peter M; Brodie Chaya
Tyrosine phosphorylation of protein kinase Cdelta is essential for its apoptotic effect in response to etoposide.
Molecular and cellular biology 2002;22(1):182-95.
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2002: Garcia-Bermejo Maria Laura; Leskow Federico Coluccio; Fujii Teruhiko; Wang Qiming; Blumberg Peter M; Ohba Motoi; Kuroki Toshio; Han Kee-Chung; Lee Jeewoo; Marquez Victor E; Kazanietz Marcelo G
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha.
The Journal of biological chemistry 2002;277(1):645-55.
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2001: Lee J; Han K C; Kang J H; Pearce L L; Lewin N E; Yan S; Benzaria S; Nicklaus M C; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.
Journal of medicinal chemistry 2001;44(25):4309-12.
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2001: Shao L; Lewin N E; Lorenzo P S; Hu Z; Enyedy I J; Garfield S H; Stone J C; Marner F J; Blumberg P M; Wang S
Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily.
Journal of medicinal chemistry 2001;44(23):3872-80.
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2001: Lee J; Lee J; Szabo T; Gonzalez A F; Welter J D; Blumberg P M
N-(3-acyloxy-2-benzylpropyl)-N'-dihydroxytetrahydrobenzazepine and tetrahydroisoquinoline thiourea analogues as vanilloid receptor ligands.
Bioorganic & medicinal chemistry 2001;9(7):1713-20.
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2001: Kedei N; Szabo T; Lile J D; Treanor J J; Olah Z; Iadarola M J; Blumberg P M
Analysis of the native quaternary structure of vanilloid receptor 1.
The Journal of biological chemistry 2001;276(30):28613-9.
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2001: Mandil R; Ashkenazi E; Blass M; Kronfeld I; Kazimirsky G; Rosenthal G; Umansky F; Lorenzo P S; Blumberg P M; Brodie C
Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.
Cancer research 2001;61(11):4612-9.
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2001: Nacro K; Sigano D M; Yan S; Nicklaus M C; Pearce L L; Lewin N E; Garfield S H; Blumberg P M; Marquez V E
An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).
Journal of medicinal chemistry 2001;44(12):1892-904.
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2001: Wang Q J; Fang T W; Nacro K; Marquez V E; Wang S; Blumberg P M
Role of hydrophobic residues in the C1b domain of protein kinase C delta on ligand and phospholipid interactions.
The Journal of biological chemistry 2001;276(22):19580-7.
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2001: Pak Y; Enyedy I J; Varady J; Kung J W; Lorenzo P S; Blumberg P M; Wang S
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.
Journal of medicinal chemistry 2001;44(11):1690-701.
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2001: Olah Z; Szabo T; Karai L; Hough C; Fields R D; Caudle R M; Blumberg P M; Iadarola M J
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1.
The Journal of biological chemistry 2001;276(14):11021-30.
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2001: Lee J; Han K C; Lee S Y; Kim S Y; Kang J H; Lewin N E; Best L S; Blumberg P M; Marquez V E
5-acyloxy-5-hydroxymethyltetrahydro-2-furancarboxylate as a novel template for protein kinase C (PKC) binding.
Farmaco (Società chimica italiana : 1989) 2001;56(3):203-10.
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2001: Lorenzo P S; Kung J W; Bottorff D A; Garfield S H; Stone J C; Blumberg P M
Phorbol esters modulate the Ras exchange factor RasGRP3.
Cancer research 2001;61(3):943-9.
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2001: Lee J; Lee J; Kim J; Kim S Y; Chun M W; Cho H; Hwang S W; Oh U; Park Y H; Marquez V E; Beheshti M; Szabo T; Blumberg P M
N-(3-Acyloxy-2-benzylpropyl)-N'-(4-hydroxy-3-methoxybenzyl) thiourea derivatives as potent vanilloid receptor agonists and analgesics.
Bioorganic & medicinal chemistry 2001;9(1):19-32.
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2000: Kronfeld I; Kazimirsky G; Lorenzo P S; Garfield S H; Blumberg P M; Brodie C
Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions.
The Journal of biological chemistry 2000;275(45):35491-8.
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2000: Tamamura H; Bienfait B; Nacro K; Lewin N E; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol (DAG). 17. Contrast between sn-1 and sn-2 DAG lactones in binding to protein kinase C.
Journal of medicinal chemistry 2000;43(17):3209-17.
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2000: Ebinu J O; Stang S L; Teixeira C; Bottorff D A; Hooton J; Blumberg P M; Barry M; Bleakley R C; Ostergaard H L; Stone J C
RasGRP links T-cell receptor signaling to Ras.
Blood 2000;95(10):3199-203.
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2000: Acs P; Beheshti M; Szállási Z; Li L; Yuspa S H; Blumberg P M
Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts.
Carcinogenesis 2000;21(5):887-91.
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2000: Lorenzo P S; Beheshti M; Pettit G R; Stone J C; Blumberg P M
The guanine nucleotide exchange factor RasGRP is a high -affinity target for diacylglycerol and phorbol esters.
Molecular pharmacology 2000;57(5):840-6.
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2000: Wang Q J; Fang T W; Fenick D; Garfield S; Bienfait B; Marquez V E; Blumberg P M
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C delta fused to green fluorescent protein.
The Journal of biological chemistry 2000;275(16):12136-46.
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2000: Nacro K; Bienfait B; Lewin N E; Blumberg P M; Marquez V E
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones.
Bioorganic & medicinal chemistry letters 2000;10(7):653-5.
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2000: Mezey E; Tóth Z E; Cortright D N; Arzubi M K; Krause J E; Elde R; Guo A; Blumberg P M; Szallasi A
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3655-60.
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2000: Nacro K; Bienfait B; Lee J; Han K C; Kang J H; Benzaria S; Lewin N E; Bhattacharyya D K; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
Journal of medicinal chemistry 2000;43(5):921-44.
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1999: Lorenzo P S; Bögi K; Hughes K M; Beheshti M; Bhattacharyya D; Garfield S H; Pettit G R; Blumberg P M
Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1.
Cancer research 1999;59(24):6137-44.
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1999: Wang Q J; Bhattacharyya D; Garfield S; Nacro K; Marquez V E; Blumberg P M
Differential localization of protein kinase C delta by phorbol esters and related compounds using a fusion protein with green fluorescent protein.
The Journal of biological chemistry 1999;274(52):37233-9.
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1999: Li L; Lorenzo P S; Bogi K; Blumberg P M; Yuspa S H
Protein kinase Cdelta targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector.
Molecular and cellular biology 1999;19(12):8547-58.
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1999: Lee J; Park S U; Kim J Y; Kim J K; Lee J; Oh U; Marquez V E; Beheshti M; Wang Q J; Modarres S; Blumberg P M
3-Acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid as novel vanilloid receptor agonists.
Bioorganic & medicinal chemistry letters 1999;9(20):2909-14.
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1999: Caloca M J; Garcia-Bermejo M L; Blumberg P M; Lewin N E; Kremmer E; Mischak H; Wang S; Nacro K; Bienfait B; Marquez V E; Kazanietz M G
beta2-chimaerin is a novel target for diacylglycerol: binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):11854-9.
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1999: Lee J; Kang J H; Lee S Y; Han K C; Torres C M; Bhattacharyya D K; Blumberg P M; Marquez V E
Protein kinase C ligands based on tetrahydrofuran templates containing a new set of phorbol ester pharmacophores.
Journal of medicinal chemistry 1999;42(20):4129-39.
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1999: Szabo T; Olah Z; Iadarola M J; Blumberg P M
Epidural resiniferatoxin induced prolonged regional analgesia to pain.
Brain research 1999;840(1-2):92-8.
-
1999: Szallasi A; Szabó T; Bíró T; Modarres S; Blumberg P M; Krause J E; Cortright D N; Appendino G
Resiniferatoxin-type phorboid vanilloids display capsaicin-like selectivity at native vanilloid receptors on rat DRG neurons and at the cloned vanilloid receptor VR1.
British journal of pharmacology 1999;128(2):428-34.
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1999: Wang S; Liu M; Lewin N E; Lorenzo P S; Bhattacharrya D; Qiao L; Kozikowski A P; Blumberg P M
Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations.
Journal of medicinal chemistry 1999;42(18):3436-46.
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1999: Szallasi A; Blumberg P M; Annicelli L L; Krause J E; Cortright D N
The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons.
Molecular pharmacology 1999;56(3):581-7.
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1999: Bögi K; Lorenzo P S; Acs P; Szállási Z; Wagner G S; Blumberg P M
Comparison of the roles of the C1a and C1b domains of protein kinase C alpha in ligand induced translocation in NIH 3T3 cells.
FEBS letters 1999;456(1):27-30.
-
1999: Szallasi A; Blumberg P M
Vanilloid (Capsaicin) receptors and mechanisms.
Pharmacological reviews 1999;51(2):159-212.
-
1999: Marquez V E; Nacro K; Benzaria S; Lee J; Sharma R; Teng K; Milne G W; Bienfait B; Wang S; Lewin N E; Blumberg P M
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.
Pharmacology & therapeutics 1999;82(2-3):251-61.
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1999: Romanova L Y; Alexandrov I A; Blagosklonny M V; Nordan R P; Garfield S; Acs P; Nguyen P; Trepel J; Blumberg P M; Mushinski J F
Regulation of actin cytoskeleton in lymphocytes: PKC-delta disrupts IL-3-induced membrane ruffles downstream of Rac1.
Journal of cellular physiology 1999;179(2):157-69.
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1999: Szallasi A; Bíró T; Szabó T; Modarres S; Petersen M; Klusch A; Blumberg P M; Krause J E; Sterner O
A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors.
British journal of pharmacology 1999;126(6):1351-8.
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1999: Brodie C; Bogi K; Acs P; Lazarovici P; Petrovics G; Anderson W B; Blumberg P M
Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(3):183-91.
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1998: Benzaria S; Bienfait B; Nacro K; Wang S; Lewin N E; Beheshti M; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol (DAG). 15. The indispensable role of the sn-1 and sn-2 carbonyls in the binding of DAG-lactones to protein kinase C (PK-C).
Bioorganic & medicinal chemistry letters 1998;8(23):3403-8.
-
1998: Brodie C; Bogi K; Acs P; Lorenzo P S; Baskin L; Blumberg P M
Protein kinase C delta (PKCdelta) inhibits the expression of glutamine synthetase in glial cells via the PKCdelta regulatory domain and its tyrosine phosphorylation.
The Journal of biological chemistry 1998;273(46):30713-8.
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1998: Szallasi A; Bíró T; Modarres S; Garlaschelli L; Petersen M; Klusch A; Vidari G; Jonassohn M; De Rosa S; Sterner O; Blumberg P M; Krause J E
Dialdehyde sesquiterpenes and other terpenoids as vanilloids.
European journal of pharmacology 1998;356(1):81-9.
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1998: Marquez V E; Sharma R; Wang S; Lewin N E; Blumberg P M; Kim I S; Lee J
Conformationally constrained analogues of diacylglycerol (DAG). 14. Dissection of the roles of the sn-1 and sn-2 carbonyls in DAG mimetics by isopharmacophore replacement.
Bioorganic & medicinal chemistry letters 1998;8(13):1757-62.
-
1998: Brodie C; Blumberg P M; Jacobson K A
Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells.
FEBS letters 1998;429(2):139-42.
-
1998: Brodie C; Kuperstein I; Acs P; Blumberg P M
Differential role of specific PKC isoforms in the proliferation of glial cells and the expression of the astrocytic markers GFAP and glutamine synthetase.
Brain research. Molecular brain research 1998;56(1-2):108-17.
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1998: Bíró T; Brodie C; Modarres S; Lewin N E; Acs P; Blumberg P M
Specific vanilloid responses in C6 rat glioma cells.
Brain research. Molecular brain research 1998;56(1-2):89-98.
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1998: Bögi K; Lorenzo P S; Szállási Z; Acs P; Wagner G S; Blumberg P M
Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cdelta: possible correlation with tumor-promoting activity.
Cancer research 1998;58(7):1423-8.
-
1998: Bíró T; Maurer M; Modarres S; Lewin N E; Brodie C; Acs G; Acs P; Paus R; Blumberg P M
Characterization of functional vanilloid receptors expressed by mast cells.
Blood 1998;91(4):1332-40.
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1998: Wang Q J; Acs P; Goodnight J; Blumberg P M; Mischak H; Mushinski J F
The catalytic domain of PKC-epsilon, in reciprocal PKC-delta and -epsilon chimeras, is responsible for conferring tumorgenicity to NIH3T3 cells, whereas both regulatory and catalytic domains of PKC-epsilon contribute to in vitro transformation.
Oncogene 1998;16(1):53-60.
-
1997: Lorenzo P S; Bögi K; Acs P; Pettit G R; Blumberg P M
The catalytic domain of protein kinase Cdelta confers protection from down-regulation induced by bryostatin 1.
The Journal of biological chemistry 1997;272(52):33338-43.
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1997: Acs P; Wang Q J; Bögi K; Marquez A M; Lorenzo P S; Bíró T; Szállási Z; Mushinski J F; Blumberg P M
Both the catalytic and regulatory domains of protein kinase C chimeras modulate the proliferative properties of NIH 3T3 cells.
The Journal of biological chemistry 1997;272(45):28793-9.
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1997: Appel E; Kolman O; Kazimirsky G; Blumberg P M; Brodie C
Regulation of GDNF expression in cultured astrocytes by inflammatory stimuli.
Neuroreport 1997;8(15):3309-12.
-
1997: Caloca M J; Fernandez N; Lewin N E; Ching D; Modali R; Blumberg P M; Kazanietz M G
Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters.
The Journal of biological chemistry 1997;272(42):26488-96.
-
1997: Biro T; Acs G; Acs P; Modarres S; Blumberg P M
Recent advances in understanding of vanilloid receptors: a therapeutic target for treatment of pain and inflammation in skin.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1997;2(1):56-60.
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1997: Acs P; Bögi K; Lorenzo P S; Marquez A M; Bíró T; Szállási Z; Blumberg P M
The catalytic domain of protein kinase C chimeras modulates the affinity and targeting of phorbol ester-induced translocation.
The Journal of biological chemistry 1997;272(35):22148-53.
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1997: Acs G; Biro T; Acs P; Modarres S; Blumberg P M
Differential activation and desensitization of sensory neurons by resiniferatoxin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(14):5622-8.
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1997: Kozikowski A P; Wang S; Ma D; Yao J; Ahmad S; Glazer R I; Bogi K; Acs P; Modarres S; Lewin N E; Blumberg P M
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.
Journal of medicinal chemistry 1997;40(9):1316-26.
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1997: Wang Q J; Acs P; Goodnight J; Giese T; Blumberg P M; Mischak H; Mushinski J F
The catalytic domain of protein kinase C-delta in reciprocal delta and epsilon chimeras mediates phorbol ester-induced macrophage differentiation of mouse promyelocytes.
The Journal of biological chemistry 1997;272(1):76-82.
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1996: Lee J; Lewin N E; Acs P; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 13. Protein kinase C ligands based on templates derived from 2,3-dideoxy-L-erythro(threo)-hexono-1,4-lactone and 2-deoxyapiolactone.
Journal of medicinal chemistry 1996;39(25):4912-9.
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1996: Szallasi A; Jonassohn M; Acs G; Bíró T; Acs P; Blumberg P M; Sterner O
The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety.
British journal of pharmacology 1996;119(2):283-90.
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1996: Lee J; Lewin N E; Blumberg P M; Marquez V E
Synthesis of bis-gamma-butyrolactones containing conformationally constrained (S)- and (R)-diacylglycerol structures.
Bioorganic & medicinal chemistry 1996;4(8):1299-305.
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1996: Szallasi Z; Bogi K; Gohari S; Biro T; Acs P; Blumberg P M
Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells.
The Journal of biological chemistry 1996;271(31):18299-301.
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1996: Wang S; Kazanietz M G; Blumberg P M; Marquez V E; Milne G W
Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.
Journal of medicinal chemistry 1996;39(13):2541-53.
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1996: Farkas-Szallasi T; Bennett G J; Blumberg P M; Hökfelt T; Lundberg J M; Szallasi A
Vanilloid receptor loss is independent of the messenger plasticity that follows systemic resiniferatoxin administration.
Brain research 1996;719(1-2):213-8.
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1996: Szallasi Z; Du L; Levine R; Lewin N E; Nguyen P N; Williams M D; Pettit G R; Blumberg P M
The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: dissociation of activities using 26-epi-bryostatin 1.
Cancer research 1996;56(9):2105-11.
-
1996: Szallasi A; Acs G; Cravotto G; Blumberg P M; Lundberg J M; Appendino G
A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor.
European journal of pharmacology 1996;299(1-3):221-8.
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1996: Szallasi A; Nilsson S; Blumberg P M; Hökfelt T; Lundberg J M
Binding of neuroleptic drugs (trifluoperazine and rimcazole) to vanilloid receptors in porcine dorsal horn.
European journal of pharmacology 1996;298(3):321-7.
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1996: Acs G; Lee J; Marquez V E; Blumberg P M
Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.
Brain research. Molecular brain research 1996;35(1-2):173-82.
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1996: Lee J; Sharma R; Wang S; Milne G W; Lewin N E; Szallasi Z; Blumberg P M; George C; Marquez V E
Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.
Journal of medicinal chemistry 1996;39(1):36-45.
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1996: Lee J; Wang S; Milne G W; Sharma R; Lewin N E; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.
Journal of medicinal chemistry 1996;39(1):29-35.
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1996: Sharma R; Lee J; Wang S; Milne G W; Lewin N E; Blumberg P M; Marquez V E
Conformationally constrained analogues of diacylglycerol. 10. Ultrapotent protein kinase C ligands based on a racemic 5-disubstituted tetrahydro-2-furanone template.
Journal of medicinal chemistry 1996;39(1):19-28.
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1996: Acs G; Palkovits M; Blumberg P M
Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations.
Life sciences 1996;59(22):1899-908.
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1995: Denning M F; Kazanietz M G; Blumberg P M; Yuspa S H
Cholesterol sulfate activates multiple protein kinase C isoenzymes and induces granular cell differentiation in cultured murine keratinocytes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1619-26.
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1995: Szallasi A; Nilsson S; Farkas-Szallasi T; Blumberg P M; Hökfelt T; Lundberg J M
Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment.
Brain research 1995;703(1-2):175-83.
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1995: Acs P; Szallasi Z; Kazanietz M G; Blumberg P M
Differential activation of PKC isozymes by 14-3-3 zeta protein.
Biochemical and biophysical research communications 1995;216(1):103-9.
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1995: Kazanietz M G; Wang S; Milne G W; Lewin N E; Liu H L; Blumberg P M
Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis.
The Journal of biological chemistry 1995;270(37):21852-9.
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1995: Szallasi Z; Denning M F; Chang E Y; Rivera J; Yuspa S H; Lehel C; Olah Z; Anderson W B; Blumberg P M
Development of a rapid approach to identification of tyrosine phosphorylation sites: application to PKC delta phosphorylated upon activation of the high affinity receptor for IgE in rat basophilic leukemia cells.
Biochemical and biophysical research communications 1995;214(3):888-94.
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1995: Haleem-Smith H; Chang E Y; Szallasi Z; Blumberg P M; Rivera J
Tyrosine phosphorylation of protein kinase C-delta in response to the activation of the high-affinity receptor for immunoglobulin E modifies its substrate recognition.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9112-6.
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1995: Acs G; Palkovits M; Blumberg P M
Trifluoperazine modulates [3H]resiniferatoxin binding by human and rat vanilloid (capsaicin) receptors and affects 45Ca uptake by adult rat dorsal root ganglion neurones.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1090-8.
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1995: Lehel C; Oláh Z; Jakab G; Szállási Z; Petrovics G; Harta G; Blumberg P M; Anderson W B
Protein kinase C epsilon subcellular localization domains and proteolytic degradation sites. A model for protein kinase C conformational changes.
The Journal of biological chemistry 1995;270(33):19651-8.
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1995: Acs G; Lee J; Marquez V E; Wang S; Milne G W; Du L; Lewin N E; Blumberg P M
Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.
Journal of neurochemistry 1995;65(1):301-18.
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1995: Kazanietz M G; Barchi J J; Omichinski J G; Blumberg P M
Low affinity binding of phorbol esters to protein kinase C and its recombinant cysteine-rich region in the absence of phospholipids.
The Journal of biological chemistry 1995;270(24):14679-84.
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1995: Kazanietz M G; Lewin N E; Bruns J D; Blumberg P M
Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity.
The Journal of biological chemistry 1995;270(18):10777-83.
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1995: Szallasi A; Blumberg P M; Lundberg J M
Proton inhibition of [3H]resiniferatoxin binding to vanilloid (capsaicin) receptors in rat spinal cord.
European journal of pharmacology 1995;289(2):181-7.
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1995: Szallasi Z; Kosa K; Smith C B; Dlugosz A A; Williams E K; Yuspa S H; Blumberg P M
Differential regulation by anti-tumor-promoting 12-deoxyphorbol-13-phenylacetate reveals distinct roles of the classical and novel protein kinase C isozymes in biological responses of primary mouse keratinocytes.
Molecular pharmacology 1995;47(2):258-65.
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1995: Denning M F; Dlugosz A A; Williams E K; Szallasi Z; Blumberg P M; Yuspa S H
Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(2):149-57.
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1995: Blumberg P M; Acs G; Acs P; Areces L B; Kazanietz M G; Lewin N E; Szallasi Z
Protein kinase C in cell signaling: strategies for the development of selective inhibitors.
Agents and actions. Supplements 1995;47():87-100.
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1994: Wang S; Zaharevitz D W; Sharma R; Marquez V E; Lewin N E; Du L; Blumberg P M; Milne G W
The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies.
Journal of medicinal chemistry 1994;37(26):4479-89.
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1994: Szallasi Z; Denning M F; Smith C B; Dlugosz A A; Yuspa S H; Pettit G R; Blumberg P M
Bryostatin 1 protects protein kinase C-delta from down-regulation in mouse keratinocytes in parallel with its inhibition of phorbol ester-induced differentiation.
Molecular pharmacology 1994;46(5):840-50.
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1994: Szallasi Z; Smith C B; Blumberg P M
Dissociation of phorbol esters leads to immediate redistribution to the cytosol of protein kinases C alpha and C delta in mouse keratinocytes.
The Journal of biological chemistry 1994;269(44):27159-62.
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1994: Szallasi A; Blumberg P M; Nilsson S; Hökfelt T; Lundberg J M
Visualization by [3H]resiniferatoxin autoradiography of capsaicin-sensitive neurons in the rat, pig and man.
European journal of pharmacology 1994;264(2):217-21.
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1994: Kazanietz M G; Lewin N E; Gao F; Pettit G R; Blumberg P M
Binding of [26-3H]bryostatin 1 and analogs to calcium-dependent and calcium-independent protein kinase C isozymes.
Molecular pharmacology 1994;46(2):374-9.
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1994: Areces L B; Kazanietz M G; Blumberg P M
Close similarity of baculovirus-expressed n-chimaerin and protein kinase C alpha as phorbol ester receptors.
The Journal of biological chemistry 1994;269(30):19553-8.
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1994: Seynaeve C M; Kazanietz M G; Blumberg P M; Sausville E A; Worland P J
Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.
Molecular pharmacology 1994;45(6):1207-14.
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1994: Acs G; Palkovits M; Blumberg P M
[3H]resiniferatoxin binding by the human vanilloid (capsaicin) receptor.
Brain research. Molecular brain research 1994;23(3):185-90.
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1994: Wang S; Milne G W; Nicklaus M C; Marquez V E; Lee J; Blumberg P M
Protein kinase C. Modeling of the binding site and prediction of binding constants.
Journal of medicinal chemistry 1994;37(9):1326-38.
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1994: Kazanietz M G; Bustelo X R; Barbacid M; Kolch W; Mischak H; Wong G; Pettit G R; Bruns J D; Blumberg P M
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products.
The Journal of biological chemistry 1994;269(15):11590-4.
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1994: Szallasi Z; Smith C B; Pettit G R; Blumberg P M
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts.
The Journal of biological chemistry 1994;269(3):2118-24.
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1994: Acs G; Blumberg P M
Comparison of [3H]resiniferatoxin binding to spinal cord and dorsal root ganglia of newborn and adult rats.
Life sciences 1994;54(24):1875-82.
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1994: Acs G; Palkovits M; Blumberg P M
Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat.
Life sciences 1994;55(13):1017-26.
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1994: Acs G; Blumberg P M
[3H]resiniferatoxin binding to pig dorsal horn membranes displays positive cooperativity.
Life sciences 1994;55(5):337-46.
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1994: Blumberg P M; Acs G; Areces L B; Kazanietz M G; Lewin N E; Szallasi Z
Protein kinase C in signal transduction and carcinogenesis.
Progress in clinical and biological research 1994;387():3-19.
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1993: Mischak H; Pierce J H; Goodnight J; Kazanietz M G; Blumberg P M; Mushinski J F
Phorbol ester-induced myeloid differentiation is mediated by protein kinase C-alpha and -delta and not by protein kinase C-beta II, -epsilon, -zeta, and -eta.
The Journal of biological chemistry 1993;268(27):20110-5.
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1993: Kazanietz M G; Areces L B; Bahador A; Mischak H; Goodnight J; Mushinski J F; Blumberg P M
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes.
Molecular pharmacology 1993;44(2):298-307.
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1993: Szallasi A; Lewin N A; Blumberg P M
Vanilloid (capsaicin) receptor in the rat: positive cooperativity of resiniferatoxin binding and its modulation by reduction and oxidation.
The Journal of pharmacology and experimental therapeutics 1993;266(2):678-83.
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1993: Lee J; Marquez V E; Blumberg P M; Krausz K W; Kazanietz M G
Conformationally constrained analogues of diacylglycerol (DAG)--II. Differential interaction of delta-lactones and gamma-lactones with protein kinase C (PK-C).
Bioorganic & medicinal chemistry 1993;1(2):119-23.
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1993: Szallasi Z; Krsmanovic L; Blumberg P M
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin.
Cancer research 1993;53(11):2507-12.
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1993: Martiny-Baron G; Kazanietz M G; Mischak H; Blumberg P M; Kochs G; Hug H; Marmé D; Schächtele C
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
The Journal of biological chemistry 1993;268(13):9194-7.
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1993: Mischak H; Goodnight J A; Kolch W; Martiny-Baron G; Schaechtle C; Kazanietz M G; Blumberg P M; Pierce J H; Mushinski J F
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.
The Journal of biological chemistry 1993;268(9):6090-6.
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1993: Szallasi A; Blumberg P M
[3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents.
Naunyn-Schmiedeberg's archives of pharmacology 1993;347(1):84-91.
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1992: Goodnight J; Kazanietz M G; Blumberg P M; Mushinski J F; Mischak H
The cDNA sequence, expression pattern and protein characteristics of mouse protein kinase C-zeta.
Gene 1992;122(2):305-11.
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1992: Szallasi Z; Krausz K W; Blumberg P M
Non-promoting 12-deoxyphorbol 13-esters as potent inhibitors of phorbol 12-myristate 13-acetate-induced acute and chronic biological responses in CD-1 mouse skin.
Carcinogenesis 1992;13(11):2161-7.
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1992: Kazanietz M G; Krausz K W; Blumberg P M
Differential irreversible insertion of protein kinase C into phospholipid vesicles by phorbol esters and related activators.
The Journal of biological chemistry 1992;267(29):20878-86.
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1992: Szallasi A; Lewin N E; Blumberg P M
Identification of alpha-1-acid glycoprotein (orosomucoid) as a major vanilloid binding protein in serum.
The Journal of pharmacology and experimental therapeutics 1992;262(3):883-8.
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1992: Lewin N E; Dell'Aquila M L; Pettit G R; Blumberg P M; Warren B S
Binding of [3H]bryostatin 4 to protein kinase C.
Biochemical pharmacology 1992;43(9):2007-14.
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1992: Hasler C M; Acs G; Blumberg P M
Specific binding to protein kinase C by ingenol and its induction of biological responses.
Cancer research 1992;52(1):202-8.
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1991: Szallasi A; Szolcsanyi J; Szallasi Z; Blumberg P M
Inhibition of [3H]resiniferatoxin binding to rat dorsal root ganglion membranes as a novel approach in evaluating compounds with capsaicin-like activity.
Naunyn-Schmiedeberg's archives of pharmacology 1991;344(5):551-6.
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1991: Szallasi Z; Blumberg P M
Prostratin, a nonpromoting phorbol ester, inhibits induction by phorbol 12-myristate 13-acetate of ornithine decarboxylase, edema, and hyperplasia in CD-1 mouse skin.
Cancer research 1991;51(19):5355-60.
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1991: Szallasi A; Blumberg P M
Characterization of vanilloid receptors in the dorsal horn of pig spinal cord.
Brain research 1991;547(2):335-8.
-
1991: Lewin N E; Pettit G R; Kamano Y; Blumberg P M
Binding of [26-3H]-epi-bryostatin 4 to protein kinase C.
Cancer communications 1991;3(3):67-70.
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1991: Szolcsanyi J; Szallasi A; Szallasi Z; Joo F; Blumberg P M
Resiniferatoxin. An ultrapotent neurotoxin of capsaicin-sensitive primary afferent neurons.
Annals of the New York Academy of Sciences 1991;632():473-5.
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1991: Blumberg P M
Complexities of the protein kinase C pathway.
Molecular carcinogenesis 1991;4(5):339-44.
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1991: Szallasi A; Blumberg P M
Molecular target size of the vanilloid (capsaicin) receptor in pig dorsal root ganglia.
Life sciences 1991;48(19):1863-9.
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1990: Szallasi A; Szallasi Z; Blumberg P M
Permanent effects of neonatally administered resiniferatoxin in the rat.
Brain research 1990;537(1-2):182-6.
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1990: Szolcsanyi J; Szallasi A; Szallasi Z; Joo F; Blumberg P M
Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons.
The Journal of pharmacology and experimental therapeutics 1990;255(2):923-8.
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1990: Szallasi A; Blumberg P M
Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes.
Brain research 1990;524(1):106-11.
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1990: Szallasi A; Blumberg P M
Effect of resiniferatoxin pretreatment on the inflammatory response to phorbol-12-myristate-13-acetate in mouse strains with different susceptibilities to phorbol ester tumor promotion.
Carcinogenesis 1990;11(4):583-7.
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1990: Szallasi A; Blumberg P M
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor.
Life sciences 1990;47(16):1399-408.
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1989: Szallasi A; Blumberg P M
Neurogenic component of phorbol ester-induced mouse skin inflammation.
Cancer research 1989;49(21):6052-7.
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1989: Szallasi A; Joo F; Blumberg P M
Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog.
Brain research 1989;503(1):68-72.
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1989: Sharkey N A; Hennings H; Yuspa S H; Blumberg P M
Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters.
Carcinogenesis 1989;10(10):1937-41.
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1989: de Vries D J; Blumberg P M
Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin.
Life sciences 1989;44(11):711-5.
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1989: Blumberg P M; Pettit G R; Warren B S; Szallasi A; Schuman L D; Sharkey N A; Nakakuma H; Dell'Aquila M L; de Vries D J
The protein kinase C pathway in tumor promotion.
Progress in clinical and biological research 1989;298():201-12.
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1989: Szallasi A; Blumberg P M
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper.
Neuroscience 1989;30(2):515-20.
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1989: Nakakuma H; Willingham M C; Blumberg P M
Effect of microinjected catalytic fragment of protein kinase C on morphological change in Swiss 3T3 cells.
Cancer communications 1989;1(2):127-32.
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1988: de Vries D J; Herald C L; Pettit G R; Blumberg P M
Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain.
Biochemical pharmacology 1988;37(21):4069-73.
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1988: Warren B S; Kamano Y; Pettit G R; Blumberg P M
Mimicry of bryostatin 1 induced phosphorylation patterns in HL-60 cells by high-phorbol ester concentrations.
Cancer research 1988;48(21):5984-8.
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1988: Wender P A; Cribbs C M; Koehler K F; Sharkey N A; Herald C L; Kamano Y; Pettit G R; Blumberg P M
Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7197-201.
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1988: Sako T; Tauber A I; Jeng A Y; Yuspa S H; Blumberg P M
Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.
Cancer research 1988;48(16):4646-50.
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1988: Dell'Aquila M L; Herald C L; Kamano Y; Pettit G R; Blumberg P M
Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells.
Cancer research 1988;48(13):3702-8.
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1988: Nakadate T; Jeng A Y; Blumberg P M
Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action.
Biochemical pharmacology 1988;37(8):1541-5.
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1988: Pasti G; Rivedal E; Yuspa S H; Herald C L; Pettit G R; Blumberg P M
Contrasting duration of inhibition of cell-cell communication in primary mouse epidermal cells by phorbol 12,13-dibutyrate and by bryostatin 1.
Cancer research 1988;48(2):447-51.
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1988: Blumberg P M
Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.
Cancer research 1988;48(1):1-8.
-
1987: Nakadate T; Blumberg P M
Modulation by palmitoylcarnitine of protein kinase C activation.
Cancer research 1987;47(24 Pt 1):6537-42.
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1987: Dell'Aquila M L; Nguyen H T; Herald C L; Pettit G R; Blumberg P M
Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells.
Cancer research 1987;47(22):6006-9.
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1987: Lacal J C; Fleming T P; Warren B S; Blumberg P M; Aaronson S A
Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product.
Molecular and cellular biology 1987;7(11):4146-9.
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1987: Sako T; Yuspa S H; Herald C L; Pettit G R; Blumberg P M
Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells.
Cancer research 1987;47(20):5445-50.
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1986: Pasti G; Lacal J C; Warren B S; Aaronson S A; Blumberg P M
Loss of mouse fibroblast cell response to phorbol esters restored by microinjected protein kinase C.
Nature 1986;324(6095):375-7.
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1986: Wender P A; Koehler K F; Sharkey N A; Dell'Aquila M L; Blumberg P M
Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(12):4214-8.
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