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Miki Shitashige

Research Profile

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Kazufumi Honda; Masahiro Kamita; Mari Masuda; Nami Miura; Masaya Ono; Miki Shitashige; Tesshi Yamada
Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine.
Lisa Kashima; Hiroaki Mita; Kazuhiro Ogi; Yasushi Sasaki; Miki Shitashige; Hiromu Suzuki; Hiroyoshi Ariga; Masashi Idogawa; Minoru Toyota; Tesshi Yamada; Takashi Tokino
CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.
Reiko Satow; Miki Shitashige; Kiyoko Fukami; Kazufumi Honda; Takafumi Jigami; Issay Kitabayashi; Tesshi Yamada
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.

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All Publications

2013: Kazufumi Honda; Masahiro Kamita; Mari Masuda; Nami Miura; Masaya Ono; Miki Shitashige; Tesshi Yamada
Proteomic approaches to the discovery of cancer biomarkers for early detection and personalized medicine.
Japanese journal of clinical oncology 2013;43(2):103-9.
2012: Lisa Kashima; Hiroaki Mita; Kazuhiro Ogi; Yasushi Sasaki; Miki Shitashige; Hiromu Suzuki; Hiroyoshi Ariga; Masashi Idogawa; Minoru Toyota; Tesshi Yamada; Takashi Tokino
CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.
The Journal of biological chemistry 2012;287(16):12975-84.
2012: Reiko Satow; Miki Shitashige; Kiyoko Fukami; Kazufumi Honda; Takafumi Jigami; Issay Kitabayashi; Tesshi Yamada
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.
Gastroenterology 2012;142(3):572-81.
2012: Kazufumi Honda; Tatsuya Ioka; Tomoo Kosuge; Hideya Kuwabara; Hideo Nagai; Shoji Nakamori; Takuji Okusaka; Norihito Ota; Yoshihiko Otsuka; Tomohiro Sakuma; Naohiro Sata; Masashi Shimahara; Takeshi Shimahara; Miki Shitashige; Akihiko Tsuchida; Markus W Büchler; Klaus Felix; Yohichi Yasunami; Tesshi Yamada
Altered plasma apolipoprotein modifications in patients with pancreatic cancer: protein characterization and multi-institutional validation.
PloS one 2012;7(10):e46908.
2011: Hideaki Ito; Hideyasu Matsuyama; Katsusuke Naito; Masaya Ono; Shigeru Sakano; Tomohiro Sakuma; Reiko Satow; Miki Shitashige; Eri Arai; Kazufumi Honda; Tesshi Yamada
Combined functional genome survey of therapeutic targets for clear cell carcinoma of the kidney.
Japanese journal of clinical oncology 2011;41(7):847-53.
2010: Reiko Satow; Miki Shitashige; Takafumi Jigami; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Traf2- and Nck-interacting kinase is essential for canonical Wnt signaling in Xenopus axis formation.
The Journal of biological chemistry 2010;285(34):26289-94.
2010: Miki Shitashige; Reiko Satow; Takafumi Jigami; Kazunori Aoki; Kazufumi Honda; Tatsuhiro Shibata; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth.
Cancer research 2010;70(12):5024-33.
2010: Reiko Satow; Miki Shitashige; Yae Kanai; Fumitaka Takeshita; Hidenori Ojima; Takafumi Jigami; Kazufumi Honda; Tomoo Kosuge; Takahiro Ochiya; Setsuo Hirohashi; Tesshi Yamada
Combined functional genome survey of therapeutic targets for hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(9):2518-28.
2010: Eisuke Kobayashi; Mari Masuda; Robert Nakayama; Hitoshi Ichikawa; Reiko Satow; Miki Shitashige; Kazufumi Honda; Umio Yamaguchi; Ayako Shoji; Naobumi Tochigi; Hideo Morioka; Yoshiaki Toyama; Setsuo Hirohashi; Akira Kawai; Tesshi Yamada
Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma.
Molecular cancer therapeutics 2010;9(3):535-44.
2009: Umio Yamaguchi; Kazufumi Honda; Reiko Satow; Eisuke Kobayashi; Robert Nakayama; Hitoshi Ichikawa; Ayako Shoji; Miki Shitashige; Mari Masuda; Akira Kawai; Hirokazu Chuman; Yukihide Iwamoto; Setsuo Hirohashi; Tesshi Yamada
Functional genome screen for therapeutic targets of osteosarcoma.
Cancer science 2009;100(12):2268-74.
2009: Ayako Negishi; Mari Masuda; Masaya Ono; Kazufumi Honda; Miki Shitashige; Reiko Satow; Tomohiro Sakuma; Hideya Kuwabara; Yukihiro Nakanishi; Yae Kanai; Ken Omura; Setsuo Hirohashi; Tesshi Yamada
Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma.
Cancer science 2009;100(9):1605-11.
2009: Ayako Negishi; Masaya Ono; Yasushi Handa; Hidenori Kato; Kohki Yamashita; Kazufumi Honda; Miki Shitashige; Reiko Satow; Tomohiro Sakuma; Hideya Kuwabara; Ken Omura; Setsuo Hirohashi; Tesshi Yamada
Large-scale quantitative clinical proteomics by label-free liquid chromatography and mass spectrometry.
Cancer science 2009;100(3):514-9.
2008: Satoru Kikuchi; Kazufumi Honda; Hitoshi Tsuda; Nobuyoshi Hiraoka; Issei Imoto; Tomoo Kosuge; Tomoko Umaki; Kaoru Onozato; Miki Shitashige; Umio Yamaguchi; Masaya Ono; Akihiko Tsuchida; Tatsuya Aoki; Johji Inazawa; Setsuo Hirohashi; Tesshi Yamada
Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(17):5348-56.
2008: Umio Yamaguchi; Robert Nakayama; Kazufumi Honda; Hitoshi Ichikawa; Tadashi Hasegawa; Miki Shitashige; Masaya Ono; Ayako Shoji; Tomohiro Sakuma; Hideya Kuwabara; Yasuhiro Shimada; Mitsuru Sasako; Tadakazu Shimoda; Akira Kawai; Setsuo Hirohashi; Tesshi Yamada
Distinct gene expression-defined classes of gastrointestinal stromal tumor.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(25):4100-8.
2008: Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Regulation of Wnt signaling by the nuclear pore complex.
Gastroenterology 2008;134(7):1961-71, 1971.e1-4.
2008: Miki Shitashige; Setsuo Hirohashi; Tesshi Yamada
Wnt signaling inside the nucleus.
Cancer science 2008;99(4):631-7.
2007: Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Increased susceptibility of Sf1(+/-) mice to azoxymethane-induced colon tumorigenesis.
Cancer science 2007;98(12):1862-7.
2007: Lin Huang; Miki Shitashige; Reiko Satow; Kazufumi Honda; Masaya Ono; Jisoo Yun; Akihiro Tomida; Takashi Tsuruo; Setsuo Hirohashi; Tesshi Yamada
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Gastroenterology 2007;133(5):1569-78.
2007: Satoru Kikuchi; Kazufumi Honda; Yasushi Handa; Hidenori Kato; Kohki Yamashita; Tomoko Umaki; Miki Shitashige; Masaya Ono; Akihiko Tsuchida; Tatsuya Aoki; Setsuo Hirohashi; Tesshi Yamada
Serum albumin-associated peptides of patients with uterine endometrial cancer.
Cancer science 2007;98(6):822-9.
2007: Miki Shitashige; Yasuyoshi Naishiro; Masashi Idogawa; Kazufumi Honda; Masaya Ono; Setsuo Hirohashi; Tesshi Yamada
Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing.
Gastroenterology 2007;132(3):1039-54.
2007: Tomohiko Hara; Kazufumi Honda; Miki Shitashige; Masaya Ono; Hideyasu Matsuyama; Katsusuke Naito; Setsuo Hirohashi; Tesshi Yamada
Mass spectrometry analysis of the native protein complex containing actinin-4 in prostate cancer cells.
Molecular & cellular proteomics : MCP 2007;6(3):479-91.
2007: Masashi Idogawa; Mitsuko Masutani; Miki Shitashige; Kazufumi Honda; Takashi Tokino; Yasuhisa Shinomura; Kohzoh Imai; Setsuo Hirohashi; Tesshi Yamada
Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.
Cancer research 2007;67(3):911-8.
2006: Kazufumi Honda; Masaya Ono; Miki Shitashige; Tesshi Yamada
[Early detection of pancreatic cancer by novel proteomic technique].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(9):1745-55.
2006: Masaya Ono; Miki Shitashige; Kazufumi Honda; Tomohiro Isobe; Hideya Kuwabara; Hirotaka Matsuzuki; Setsuo Hirohashi; Tesshi Yamada
Label-free quantitative proteomics using large peptide data sets generated by nanoflow liquid chromatography and mass spectrometry.
Molecular & cellular proteomics : MCP 2006;5(7):1338-47.
2002: Takeo Nomura; Hideyuki Yamamoto; Hiromitsu Mimata; Miki Shitashige; Futoshi Shibasaki; Eishichi Miyamoto; Yoshio Nomura
Enhancement by cyclosporin A of taxol-induced apoptosis of human urinary bladder cancer cells.
Urological research 2002;30(2):102-11.
2002: Kazuyuki Noguchi; Miki Shitashige; Hirahito Endo; Hirobumi Kondo; Isao Ishikawa
Binary regulation of interleukin (IL)-6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1beta-stimulated human gingival fibroblasts.
Journal of periodontal research 2002;37(1):29-36.
2001: Miki Shitashige; M Toi; T Yano; M Shibata; Y Matsuo; Futoshi Shibasaki
Dissociation of Bax from a Bcl-2/Bax heterodimer triggered by phosphorylation of serine 70 of Bcl-2.
Journal of biochemistry 2001;130(6):741-8.
2001: Kazuyuki Noguchi; K Iwasaki; Miki Shitashige; Makoto Umeda; Y Izumi; Sei-Itsu Murota; Isao Ishikawa
Downregulation of lipopolysaccharide-induced intercellular adhesion molecule-1 expression via EP2/EP4 receptors by prostaglandin E2 in human fibroblasts.
Inflammation 2001;25(2):75-81.
1999: K Noguchi; K Iwasaki; Miki Shitashige; S Murato; Isao Ishikawa
Prostaglandin E2 downregulates interferon-gamma-induced intercellular adhesion molecule-1 expression via EP2 receptors in human gingival fibroblasts.
Inflammation 1999;23(5):481-93.
1999: Miki Shitashige; Ikuo Morita; Sei-Itsu Murota
Existence of endogenous inhibitor(s) of prostaglandin endoperoxide H synthase activities in murine NIH3T3 fibroblasts.
Prostaglandins, leukotrienes, and essential fatty acids 1999;61(2):97-103.
1999: K Noguchi; Miki Shitashige; H Watanabe; Sei-Itsu Murota; Isao Ishikawa
Interleukin-4 and interferon-gamma inhibit prostaglandin production by interleukin-1beta-stimulated human periodontal ligament fibroblasts.
Inflammation 1999;23(1):1-13.
1998: Miki Shitashige; Futoshi Shibasaki
[The role of calcineurin in Ca(2+)-mediated apoptosis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(12 Suppl):1877-83.
1998: Miki Shitashige; Ikuo Morita; Sei-Itsu Murota
Different substrate utilization between prostaglandin endoperoxide H synthase-1 and -2 in NIH3T3 fibroblasts.
Biochimica et biophysica acta 1998;1389(1):57-66.
1997: Kaoru Irie; Fujiko Tsukahara; E Fujii; Y Uchida; Toshimasa Yoshioka; W R He; Miki Shitashige; Sei-Itsu Murota; Takamura Muraki
Cationic amino acid transporter-2 mRNA induction by tumor necrosis factor-alpha in vascular endothelial cells.
European journal of pharmacology 1997;339(2-3):289-93.