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Kevan Shokat

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Miriam Merzel Schachter; Kevan M Shokat; Chao Zhang; Alexander Hirschi; Stéphane Larochelle; Karl A Merrick; Seth M Rubin; Robert P Fisher
A cdk7-cdk4 T-loop phosphorylation cascade promotes g1 progression.
Sebastian Lourido; Kevan M Shokat; Jennifer Barks; Michael S Lopez; Keliang Tang; Qiuling Wang; Scott A Wildman; Chao Zhang; L David Sibley
Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii.
Krista Kaasik; Holger Kissel; Saul Kivimäe; Louis J Ptácek; Kevan M Shokat; Jasmina J Allen; Kristin Baer; Alma L Burlingame; Robert J Chalkley; Yong Huang; Ying-Hui Fu
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.

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All Publications

2013: Miriam Merzel Schachter; Kevan M Shokat; Chao Zhang; Alexander Hirschi; Stéphane Larochelle; Karl A Merrick; Seth M Rubin; Robert P Fisher
A cdk7-cdk4 T-loop phosphorylation cascade promotes g1 progression.
Molecular cell 2013;50(2):250-60.
2013: Sebastian Lourido; Kevan M Shokat; Jennifer Barks; Michael S Lopez; Keliang Tang; Qiuling Wang; Scott A Wildman; Chao Zhang; L David Sibley
Optimizing Small Molecule Inhibitors of Calcium-Dependent Protein Kinase 1 to Prevent Infection by Toxoplasma gondii.
Journal of medicinal chemistry 2013;56(7):3068-77.
2013: Krista Kaasik; Holger Kissel; Saul Kivimäe; Louis J Ptácek; Kevan M Shokat; Jasmina J Allen; Kristin Baer; Alma L Burlingame; Robert J Chalkley; Yong Huang; Ying-Hui Fu
Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.
Cell metabolism 2013;17(2):291-302.
2012: Michael J Soskis; Chao Zhang; Janine Zieg; Bulent Ataman; Brenda L Bloodgood; Christopher William Cowan; Hsin-Yi Henry Ho; Athar N Malik; Michael A Robichaux; Alex A Rubin; Nikhil Sharma; Kevan M Shokat; Michael E Greenberg
A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.
Nature neuroscience 2012;15(12):1645-54.
2012: Chloe E Atreya; Emily K Bergsland; Gregory S Ducker; Morris E Feldman; Robert S Warren; Kevan M Shokat
Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer.
Investigational new drugs 2012;30(6):2219-25.
2012: Stéphane Larochelle; Miriam Sansó; Kevan M Shokat; Chao Zhang; Jasmina J Allen; Ramon Amat; David L Bentley; Kira Glover-Cutter; Robert P Fisher
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.
Nature structural & molecular biology 2012;19(11):1108-15.
2012: Elton T Young; Chao Zhang; Pabitra K Parua; Kevan M Shokat; Katherine A Braun
The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae.
The Journal of biological chemistry 2012;287(34):29021-34.
2012: Miran Jang; Jyothi K R; Amarjargal Dashdorj; Joohun Ha; Si-Young Kim; Yeonghwan Kim; Sangbin Lim; Yoo Hong Min; Kevan M Shokat; Hyeran Won; Sung Soo Kim
Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide.
Cancer research 2012;72(16):4214-24.
2012: Lara Wohlbold; Chao Zhang; Jasmina J Allen; Ramon Amat; Saurav De; Jun Hyun Kim; Stéphane Larochelle; Karl A Merrick; John H J Petrini; Kevan M Shokat; Robert P Fisher
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells.
PLoS genetics 2012;8(8):e1002935.
2012: Chun Chen; Xiaozhu Huang; Makoto Kudo; Candace Lee; Kathryn Robinett; Florentine Rutaganira; Kevan M Shokat; Hiromi Takano; Toshimitsu Uede; Paul J Wolters; Amha Atakilit; Dean Sheppard
Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing.
The Journal of clinical investigation 2012;122(8):2916-27.
2012: Christine K Cheng; Elizabeth Charron; Andrei Goga; Nathanael S Gray; W Clay Gustafson; Benjamin T Houseman; C David James; Scott A Oakes; Brian Pollok; Kevan M Shokat; William A Weiss; Eli Zunder; Qi-Wen Fan
Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(31):12722-7.
2012: Courtney V St Amour; Chao Zhang; Christian A Bösken; Matthias Geyer; Stéphane Larochelle; Karen M Lee; Miriam Sansó; Kevan M Shokat; Robert P Fisher
Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.
Molecular and cellular biology 2012;32(13):2372-83.
2012: Colm J Ryan; Michael Shales; Kevan M Shokat; J Peter Svensson; Chao Tang; Zongtian Tong; Elena Tosti; Jiewei Xu; Pedro Beltrao; Gerard Cagney; Sean R Collins; Pádraig Cunningham; Winfried Edelmann; Peter J Espenshade; Derek Greene; Christine Guthrie; Trey Ideker; Harlizawati Jahari; Lingli Jiang; Michael-Christopher Keogh; Hyun-Soo Kim; Joseph I Kliegman; Dwight Kuo; Kristin Patrick; Hong Qu; Assen Roguev; Nevan J Krogan
Hierarchical modularity and the evolution of genetic interactomes across species.
Molecular cell 2012;46(5):691-704.
2012: Arvin C Dar; Tirtha K Das; Kevan M Shokat; Ross L Cagan
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.
Nature 2012;486(7401):80-4.
2012: Yidi Sun; Hiromu Takematsu; Yukari Yamane; Chao Zhang; Yasunori Kozutsumi; Yansong Miao; Kevan M Shokat; David G Drubin
Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways.
Molecular biology of the cell 2012;23(12):2388-98.
2012: Andrew C Hsieh; Nicholas T Ingolia; Matthew R Janes; Katti Jessen; Yi Liu; Michael Martin; Pingda Ren; Christian Rommel; Michael J Bonham; Carly Christensen; Merritt P Edlind; Morris E Feldman; Annie Sher; Evan Y Shi; Kevan M Shokat; Craig R Stumpf; Shunyou Wang; Jonathan S Weissman; Davide Ruggero
The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Nature 2012;485(7396):55-61.
2012: Krister J Barkovich; Jimmy A Blair; Qi-Wen Fan; Adam L Garske; Sujatmi Hariono; Theodore paul nicolaides; Kevan M Shokat; Jie Zhang; William A Weiss
Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers.
Cancer discovery 2012;2(5):450-7.
2012: Rutger C C Hengeveld; Nicholas T Hertz; Kevan M Shokat; Martijn J M Vromans; Chao Zhang; Alma L Burlingame; Susanne M A Lens
Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex.
Molecular & cellular proteomics : MCP 2012;11(5):47-59.
2012: Dai Horiuchi; Leonard Kusdra; Karl A Merrick; Kevan M Shokat; Lara Wohlbold; Chao Zhang; Noelle E Huskey; Katelyn J Creasman; Robert P Fisher; Andrei Goga
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(17):E1019-27.
2012: Joseph M Savitt; Kevan M Shokat; Dolly Singh; Liang-Chin Chen; Janet Folmer; Chao Zhang; William W Wright
The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult.
Stem cells (Dayton, Ohio) 2012;30(4):732-40.
2012: Sila K Ultanir; Guangnan Li; Samuel J Pleasure; Kevan M Shokat; Alma L Burlingame; Woo-Ping Ge; Nicholas T Hertz; Lily Yeh Jan; Yuh Nung Jan
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development.
Neuron 2012;73(6):1127-42.
2012: Matthew D Simon; Kevan M Shokat
A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins.
Methods in enzymology 2012;512():57-69.
2012: Miriam Sansó; Beate Schwer; Kevan M Shokat; Courtney V St Amour; Robert P Fisher; Pierre-Étienne Jacques; Karen M Lee; Stephen Nagy; Viviane Pagé; Ariane Racine; François Robert; Laia Viladevall; Chao Zhang; Jason C Tanny
A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast.
PLoS genetics 2012;8(8):e1002822.
2012: Elena Cibrián Uhalte; Stefan Donat; Nicole Hellwig; Marieluise Kirchner; Matthias Selbach; Kevan M Shokat; Jasmina J Allen; Salim Abdelilah-Seyfried
In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish.
PloS one 2012;7(6):e40000.
2012: Alexander V Statsuk; Kevan M Shokat
Covalent cross-linking of kinases with their corresponding peptide substrates.
Methods in molecular biology (Clifton, N.J.) 2012;795():179-90.
2011: Lubos Cipak; Ines Kovacikova; Eva Miadokova; Cornelia Rumpf; Kevan M Shokat; Chao Zhang; Juraj Gregan
Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe.
Cell cycle (Georgetown, Tex.) 2011;10(20):3527-32.
2011: Jamie R Schoenborn; Kevan M Shokat; Ying Xim Tan; Chao Zhang; Arthur Weiss
Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.
Science signaling 2011;4(190):ra59.
2011: Beatrice T Wang; Rebecca Barbeau; Andrea Barczak; Gregory S Ducker; David J Erle; Kevan M Shokat
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15201-6.
2011: Adam L Garske; Jenny L Perez; Ulf Peters; Arianna T Cortesi; Kevan M Shokat
Chemical genetic strategy for targeting protein kinases based on covalent complementarity.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15046-52.
2011: Akira Yoshii; Chao Zhang; Jihye Kim; Yasunobu Murata; Kevan M Shokat; Martha Constantine-Paton
TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(33):11894-904.
2011: Karl A Merrick; Kevan M Shokat; Lara Wohlbold; Chao Zhang; Jasmina J Allen; Andrei Goga; Dai Horiuchi; Noelle E Huskey; Robert P Fisher
Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation.
Molecular cell 2011;42(5):624-36.
2011: Arvin C Dar; Kevan M Shokat
The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.
Annual review of biochemistry 2011;80():769-95.
2011: Damian F Brennan; Arvin C Dar; Nicholas T Hertz; William C H Chao; Alma L Burlingame; Kevan M Shokat; David Barford
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Nature 2011;472(7343):366-9.
2011: Eunyoung Tak; Seonmin Lee; J Lee; M A Rashid; Youn-Wha Kim; Jae-Hoon Park; Won Sang Park; Kevan M Shokat; Joohun Ha; Sung Soo Kim
Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells.
Journal of hepatology 2011;54(2):328-39.
2011: Dor Salomon; Kevan M Shokat; Chao Zhang; Guido Sessa
Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules.
Methods in molecular biology (Clifton, N.J.) 2011;779():185-97.
2011: Alexei V Korennykh; Andrei A Korostelev; Kevan M Shokat; Robert M Stroud; Pascal F Egea; Janet Finer-Moore; Chao Zhang; Peter Walter
Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1.
BMC biology 2011;9():48.
2011: Alexei V Korennykh; Andrei A Korostelev; Kevan M Shokat; Robert M Stroud; Pascal F Egea; Janet Finer-Moore; Chao Zhang; Peter Walter
Structural and functional basis for RNA cleavage by Ire1.
BMC biology 2011;9():47.
2010: Sourav Bandyopadhyay; Monika Mehta; Dwight Kuo; Min-Kyung Sung; Ryan Chuang; Eric J Jaehnig; Bernd Bodenmiller; Katherine Licon; Wilbert Copeland; Michael Shales; Dorothea Fiedler; Janusz Dutkowski; Aude Guénolé; Haico Van Attikum; Kevan M Shokat; Richard D Kolodner; Won-Ki Huh; Ruedi Aebersold; Michael-Christopher Keogh; Nevan J Krogan; Trey Ideker
Rewiring of genetic networks in response to DNA damage.
Science (New York, N.Y.) 2010;330(6009):1385-9.
2010: Uyanga Chuluunbaatar; Richard Roller; Morris E Feldman; Stuart Brown; Kevan M Shokat; Ian Mohr
Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.
Genes & development 2010;24(23):2627-39.
2010: Byron B Au-Yeung; Susan E Levin; Chao Zhang; Lih-Yun Hsu; Debra A Cheng; Nigel Killeen; Kevan M Shokat; Arthur Weiss
A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
Nature immunology 2010;11(12):1085-92.
2010: Tao Su; David M Bryant; Frédéric Luton; Marcel Vergés; Scott M Ulrich; Kirk Hansen; Anirban Datta; Dennis J Eastburn; Al L Burlingame; Kevan M Shokat; Keith E Mostov
A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
Nature cell biology 2010;12(12):1143-53.
2010: Wen-Hai Chou; Dan Wang; Thomas McMahon; Zhan-Heng Qi; Maengseok Song; Chao Zhang; Kevan M Shokat; Robert O Messing
GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(42):13955-65.
2010: Joshua R Tietjen; David W Zhang; Juan B Rodríguez-Molina; Brent E White; Md Sohail Akhtar; Martin Heidemann; Xin Li; Rob D Chapman; Kevan M Shokat; Sündüz Keles; Dirk Eick; Aseem Z Ansari
Chemical-genomic dissection of the CTD code.
Nature structural & molecular biology 2010;17(9):1154-61.
2010: Tatsuya Okuzumi; Gregory S Ducker; Chao Zhang; Brian Aizenstein; Randy Hoffman; Kevan M Shokat
Synthesis and evaluation of indazole based analog sensitive Akt inhibitors.
Molecular bioSystems 2010;6(8):1389-402.
2010: John Maciejowski; Kelly A George; Marie-Emilie Terret; Chao Zhang; Kevan M Shokat; Prasad V Jallepalli
Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.
The Journal of cell biology 2010;190(1):89-100.
2010: Sebastian Lourido; Joel Shuman; Chao Zhang; Kevan M Shokat; Raymond Hui; L David Sibley
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.
Nature 2010;465(7296):359-62.
2010: Ming Lu; Jian Wang; Kevin T Jones; Harlan E Ives; Morris E Feldman; Li-jun Yao; Kevan M Shokat; Kaveh Ashrafi; David Pearce
mTOR complex-2 activates ENaC by phosphorylating SGK1.
Journal of the American Society of Nephrology : JASN 2010;21(5):811-8.
2010: Kevan M Shokat
A drug-drug interaction crystallizes a new entry point into the UPR.
Molecular cell 2010;38(2):161-3.
2010: Songon AN; Minjoung Kyoung; Jasmina J Allen; Kevan M Shokat; Stephen J Benkovic
Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2.
The Journal of biological chemistry 2010;285(15):11093-9.
2010: Simon Miller; Brandon Tavshanjian; Arkadiusz Oleksy; Olga Perisic; Benjamin T Houseman; Kevan M Shokat; Roger L Williams
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.
Science (New York, N.Y.) 2010;327(5973):1638-42.
2010: Poulikos I Poulikakos; Chao Zhang; Gideon Bollag; Kevan M Shokat; Neal Rosen
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
Nature 2010;464(7287):427-30.
2010: Andrew C Hsieh; Maria Costa; Ornella Zollo; Cole Davis; Morris E Feldman; Joseph R Testa; Oded Meyuhas; Kevan M Shokat; Davide Ruggero
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E.
Cancer cell 2010;17(3):249-61.
2010: Olusegun Williams; Benjamin T Houseman; Eric J Kunkel; Brian Aizenstein; Randy Hoffman; Zachary A Knight; Kevan M Shokat
Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.
Chemistry & biology 2010;17(2):123-34.
2010: Hans K Carlson; Lars Plate; Mark S Price; Jasmina J Allen; Kevan M Shokat; Michael A Marletta
Use of a semisynthetic epitope to probe histidine kinase activity and regulation.
Analytical biochemistry 2010;397(2):139-43.
2010: Jérémie Roux; Michel Carles; Hidefumi Koh; Arnaud Goolaerts; Michael T Ganter; Brian B Chesebro; Marybeth Howard; Benjamin T Houseman; Walter E Finkbeiner; Kevan M Shokat; Agnès C Paquet; Michael A Matthay; Jean-François Pittet
Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.
The Journal of biological chemistry 2010;285(7):4278-90.
2010: Zachary A Knight; Henry Lin; Kevan M Shokat
Targeting the cancer kinome through polypharmacology.
Nature reviews. Cancer 2010;10(2):130-7.
2010: Alex Berndt; Simon Miller; Olusegun Williams; Daniel D Le; Benjamin T Houseman; Joseph I Pacold; Fabrice Gorrec; Wai-Ching Hon; Yi Liu; Christian Rommel; Pascale Gaillard; Thomas Rückle; Matthias K Schwarz; Kevan M Shokat; Jeffrey P Shaw; Roger L Williams
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.
Nature chemical biology 2010;6(2):117-24.
2010: Dhara N Amin; Natalia Sergina; Deepika Ahuja; Martin McMahon; Jimmy A Blair; Donghui Wang; Byron Hann; Kevin M Koch; Kevan M Shokat; Mark M Moasser
Resiliency and vulnerability in the HER2-HER3 tumorigenic driver.
Science translational medicine 2010;2(16):16ra7.
2010: Bernd Bodenmiller; Stefanie Wanka; Claudine Kraft; Jörg Urban; David Campbell; Patrick G Pedrioli; Bertran Gerrits; Paola Picotti; Henry Lam; Olga Vitek; Mi-Youn Brusniak; Bernd Roschitzki; Chao Zhang; Kevan M Shokat; Ralph Schlapbach; Alejandro Colman-Lerner; Garry P Nolan; Alexey I Nesvizhskii; Matthias Peter; Robbie Loewith; Christian von Mering; Ruedi Aebersold
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast.
Science signaling 2010;3(153):rs4.
2010: Qi-Wen Fan; Christine Cheng; Christopher S Hackett; Morri Feldman; Benjamin T Houseman; Theodore paul nicolaides; Daphne A Haas-Kogan; C David James; Scott A Oakes; Jayanta Debnath; Kevan M Shokat; William A Weiss
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Science signaling 2010;3(147):ra81.
2010: Morris E Feldman; Kevan M Shokat
New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).
Current topics in microbiology and immunology 2010;347():241-62.
2010: Tale Sliedrecht; Chao Zhang; Kevan M Shokat; Geert J P L Kops
Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis.
PloS one 2010;5(4):e10251.
2009: Hengyao Niu; Lihong Wan; Valeria Busygina; YoungHo Kwon; Jasmina A Allen; Xue Li; Ryan C Kunz; Kazuishi Kubota; Beatrice Wang; Patrick Sung; Kevan M Shokat; Steven P Gygi; Nancy M Hollingsworth
Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation.
Molecular cell 2009;36(3):393-404.
2009: Martin L Sos; Stefanie Fischer; Roland Ullrich; Martin Peifer; Johannes M Heuckmann; Mirjam Koker; Stefanie Heynck; Isabel Stückrath; Jonathan Weiss; Florian Fischer; Kathrin Michel; Aviva Goel; Lucia Regales; Katerina A Politi; Samanthi Perera; Matthäus Getlik; Lukas C Heukamp; Sascha Ansén; Thomas Zander; Rameen Beroukhim; Hamid Kashkar; Kevan M Shokat; William R Sellers; Daniel Rauh; Christine Orr; Klaus P Hoeflich; Lori Friedman; Kwok-Kin Wong; William Pao; Roman K Thomas
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(43):18351-6.
2009: Shane P Herbert; Jan Huisken; Tyson N Kim; Morri E Feldman; Benjamin T Houseman; Rong A Wang; Kevan M Shokat; Didier Y R Stainier
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.
Science (New York, N.Y.) 2009;326(5950):294-8.
2009: Ying Liu; Linda Warfield; Chao Zhang; Jie Luo; Jasmina Allen; Walter H Lang; Jeffrey A Ranish; Kevan M Shokat; Steven Hahn
Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex.
Molecular and cellular biology 2009;29(17):4852-63.
2009: Tatsuya Okuzumi; Dorothea Fiedler; Chao Zhang; Daniel C Gray; Brian Aizenstein; Randy Hoffman; Kevan M Shokat
Inhibitor hijacking of Akt activation.
Nature chemical biology 2009;5(7):484-93.
2009: Pedro Beltrao; Jonathan C Trinidad; Dorothea Fiedler; Assen Roguev; Wendell A Lim; Kevan M Shokat; Alma L Burlingame; Nevan J Krogan
Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
PLoS biology 2009;7(6):e1000134.
2009: Haidong Wang; Boyko Kakaradov; Sean R Collins; Lena Karotki; Dorothea Fiedler; Michael Shales; Kevan M Shokat; Tobias C Walther; Nevan J Krogan; Daphne Koller
A complex-based reconstruction of the Saccharomyces cerevisiae interactome.
Molecular & cellular proteomics : MCP 2009;8(6):1361-81.
2009: Dor Salomon; Arale Bonshtien; Maya Mayrose; Chao Zhang; Kevan M Shokat; Guido Sessa
Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands.
The Journal of biological chemistry 2009;284(22):15289-98.
2009: Matthias Niedermeier; Bryan T. J. Hennessy; Zachary A Knight; Marina Henneberg; Jianhua Hu; Antonina V Kurtova; William G Wierda; Michael J Keating; Kevan M Shokat; Jan A Burger
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.
Blood 2009;113(22):5549-57.
2009: Mark E Burkard; John Maciejowski; Verónica Rodriguez-Bravo; Michael Repka; Drew M Lowery; Karl R Clauser; Chao Zhang; Kevan M Shokat; Steve Carr; Michael B Yaffe; Prasad V Jallepalli
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.
PLoS biology 2009;7(5):e1000111.
2009: Quincey A Justman; Zach Serber; James E Ferrell; Hana El-Samad; Kevan M Shokat
Tuning the activation threshold of a kinase network by nested feedback loops.
Science (New York, N.Y.) 2009;324(5926):509-12.
2009: Laia Viladevall; Courtney V St Amour; Adam Rosebrock; Susanne Schneider; Chao Zhang; Jasmina J Allen; Kevan M Shokat; Beate Schwer; Janet K Leatherwood; Robert P Fisher
TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast.
Molecular cell 2009;33(6):738-51.
2009: Laura M Sly; Melisa J Hamilton; Etsushi Kuroda; Victor W Ho; Frann L Antignano; Stephanie L Omeis; Christina J van Netten-Thomas; Dana Wong; Hayley K Brugger; Olusegun Williams; Morris E Feldman; Benjamin T Houseman; Dorothea Fiedler; Kevan M Shokat; Gerald Krystal
SHIP prevents lipopolysaccharide from triggering an antiviral response in mice.
Blood 2009;113(13):2945-54.
2009: Dorothea Fiedler; Hannes Braberg; Monika Mehta; Gal Chechik; Gerard Cagney; Paromita Mukherjee; Andrea C Silva; Michael Shales; Sean R Collins; sake wageningen; Patrick Kemmeren; Frank C P Holstege; Jonathan S Weissman; Michael-Christopher Keogh; Daphne Koller; Kevan M Shokat; Nevan J Krogan
Functional organization of the S. cerevisiae phosphorylation network.
Cell 2009;136(5):952-63.
2009: Morris E Feldman; Beth Apsel; Aino Uotila; Robbie Loewith; Zachary A Knight; Davide Ruggero; Kevan M Shokat
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
PLoS biology 2009;7(2):e38.
2009: Alexei V Korennykh; Pascal F Egea; Andrei A Korostelev; Janet Finer-Moore; Chao Zhang; Kevan M Shokat; Robert M Stroud; Peter Walter
The unfolded protein response signals through high-order assembly of Ire1.
Nature 2009;457(7230):687-93.
2009: Olga K Mirzoeva; Debopriya Das; Laura M Heiser; Sanchita Bhattacharya; Doris Siwak; Rina Gendelman; Nora Bayani; Nicholas J Wang; Richard M Neve; Yinghui Guan; Zhi Hu; Zachary A Knight; Heidi S Feiler; Philippe Gascard; Bahram Parvin; Paul Spellman; Kevan M Shokat; Andrew J Wyrobek; Mina J Bissell; Frank McCormick; Wen-Lin Kuo; Gordon B Mills; Joe Gray; W Michael Korn
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition.
Cancer research 2009;69(2):565-72.
2009: Allison L Miller; Chao Zhang; Kevan M Shokat; Clifford A Lowell
Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(2):988-98.
2009: Shang Li; Svetlana Makovets; Tetsuya Matsuguchi; Justin D Blethrow; Kevan M Shokat; Elizabeth H Blackburn
Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.
Cell 2009;136(1):50-61.
2009: Qi-Wen Fan; Christine Cheng; Zachary A Knight; Daphne A Haas-Kogan; David Stokoe; C David James; Frank McCormick; Kevan M Shokat; William A Weiss
EGFR signals to mTOR through PKC and independently of Akt in glioma.
Science signaling 2009;2(55):ra4.
2008: Daniel J Morgan; Michael Weisenhaus; Sara Shum; Thomas Su; Ruimao Zheng; Chao Zhang; Kevan M Shokat; Bertil Hille; Donner F Babcock; G Stanley McKnight
Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(52):20740-5.
2008: Karl A Merrick; Stéphane Larochelle; Chao Zhang; Jasmina J Allen; Kevan M Shokat; Robert P Fisher
Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells.
Molecular cell 2008;32(5):662-72.
2008: Cornelia Kurischko; Venkata K Kuravi; Nattha Wannissorn; Pavel A Nazarov; Michelle Husain; Chao Zhang; Kevan M Shokat; J Michael McCaffery; Francis C Luca
The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion.
Molecular biology of the cell 2008;19(12):5559-78.
2008: Doo-Sup Choi; Weizheng Wei; J Kevin Deitchman; Viktor Kharazia; Heidi M B Lesscher; Thomas McMahon; Dan Wang; Zhan-Heng Qi; Werner Sieghart; Chao Zhang; Kevan M Shokat; Istvan Mody; Robert O Messing
Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):11890-9.
2008: Jungseog Kang; Maojun Yang; Bing Li; Wei Qi; Chao Zhang; Kevan M Shokat; Diana R Tomchick; Mischa Machius; Hongtao Yu
Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Molecular cell 2008;32(3):394-405.
2008: Beth Apsel; Jimmy A Blair; Beatriz Gonzalez; Tamim Nazif; Morri E Feldman; Brian Aizenstein; Randy Hoffman; Roger L Williams; Kevan M Shokat; Zachary A Knight
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
Nature chemical biology 2008;4(11):691-9.
2008: Arvin C Dar; Michael S Lopez; Kevan M Shokat
Small molecule recognition of c-Src via the Imatinib-binding conformation.
Chemistry & biology 2008;15(10):1015-22.
2008: Risa Chaisuparat; Jiadi Hu; Bruno C Jham; Zachary A Knight; Kevan M Shokat; Silvia Montaner
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma.
Cancer research 2008;68(20):8361-8.
2008: Ting-Ting Zhang; Klaus Okkenhaug; Baher F Nashed; Kamal D Puri; Zachary A Knight; Kevan M Shokat; Bart Vanhaesebroeck; Aaron J Marshall
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
The Journal of allergy and clinical immunology 2008;122(4):811-819.e2.
2008: Katsutoshi Oda; Jennifer Okada; Luika Timmerman; Pablo Rodriguez-Viciana; David Stokoe; Keiko Shoji; Yuji Taketani; Hiroyuki Kuramoto; Zachary A Knight; Kevan M Shokat; Frank McCormick
PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation.
Cancer research 2008;68(19):8127-36.
2008: Xu Lu; Matthew D Simon; Jayanth V Chodaparambil; Jeffrey C Hansen; Kevan M Shokat; Karolin Luger
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
Nature structural & molecular biology 2008;15(10):1122-4.
2008: Neil E Torbett; Antonio Luna-Moran; Zachary A Knight; Andrew Houk; Mark M Moasser; William Weiss; Kevan M Shokat; David Stokoe
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
The Biochemical journal 2008;415(1):97-110.
2008: Olivier Sordet; Stéphane Larochelle; Estelle Nicolas; Ellen V Stevens; Chao Zhang; Kevan M Shokat; Robert P Fisher; Yves Pommier
Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I.
Journal of molecular biology 2008;381(3):540-9.
2008: Michael G Kharas; Matthew R Janes; Vanessa M Scarfone; Michael B Lilly; Zachary A Knight; Kevan M Shokat; David A Fruman
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.
The Journal of clinical investigation 2008;118(9):3038-50.
2008: Alexander W Johnson; Xi Chen; Hans S Crombag; Chao Zhang; Dani R Smith; Kevan M Shokat; Michela Gallagher; Peter C Holland; David D Ginty
The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value.
The European journal of neuroscience 2008;28(5):997-1002.
2008: Jian Wang; Zachary A Knight; Dorothea Fiedler; Olusegun Williams; Kevan M Shokat; David Pearce
Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport.
American journal of physiology. Renal physiology 2008;295(3):F843-50.
2008: Eli R Zunder; Zachary A Knight; Benjamin T Houseman; Beth Apsel; Kevan M Shokat
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.
Cancer cell 2008;14(2):180-92.
2008: Shawn Hoon; Andrew M Smith; Iain M Wallace; Sundari Suresh; Molly Miranda; Eula Fung; Michael Proctor; Kevan M Shokat; Chao Zhang; Ronald W Davis; Guri Giaever; Robert P St Onge; Robert P StOnge; Corey Nislow
An integrated platform of genomic assays reveals small-molecule bioactivities.
Nature chemical biology 2008;4(8):498-506.
2008: Hyeon Ho Kim; Kotb Abdelmohsen; Ashish Lal; Rudolf Pullmann; Xiaoling Yang; Stefanie Galban; Subramanya Srikantan; Jennifer L Martindale; Justin D Blethrow; Kevan M Shokat; Myriam Gorospe
Nuclear HuR accumulation through phosphorylation by Cdk1.
Genes & development 2008;22(13):1804-15.
2008: Stephan Sauer; Ludovica Bruno; Arnulf Hertweck; David Finlay; Marion Leleu; Mikhail Spivakov; Zachary A Knight; Bradley S Cobb; Doreen Cantrell; Eric O'connor; Kevan M Shokat; Amanda G Fisher; Matthias Merkenschlager
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(22):7797-802.
2008: Susan E Levin; Chao Zhang; Theresa A Kadlecek; Kevan M Shokat; Arthur Weiss
Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
The Journal of biological chemistry 2008;283(22):15419-30.
2008: Jack S Chen; Linda J Zhou; Michal Entin-Meer; Xiaodong Yang; Mila Donker; Zachary A Knight; William Weiss; Kevan M Shokat; Daphne A Haas-Kogan; David Stokoe
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma.
Molecular cancer therapeutics 2008;7(4):841-50.
2008: Andras Balla; Galina Tuymetova; Balazs Toth; Zsofia Szentpetery; X Zhao; Zachary A Knight; Kevan M Shokat; Peter J Steinbach; Tamas Balla
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling.
Biochemistry 2008;47(6):1599-607.
2008: Justin D Blethrow; Joseph Stephen Glavy; David O Morgan; Kevan M Shokat
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1442-7.
2008: Lihong Wan; Hengyao Niu; Bruce Futcher; Chao Zhang; Kevan M Shokat; Simon J Boulton; Nancy M Hollingsworth
Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast.
Genes & development 2008;22(3):386-97.
2008: Andras Balla; Yeon-Ju Kim; Péter Várnai; Zsofia Szentpetery; Zachary A Knight; Kevan M Shokat; Tamas Balla
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha.
Molecular biology of the cell 2008;19(2):711-21.
2008: Eric M Rubenstein; Rhonda R McCartney; Chao Zhang; Kevan M Shokat; Margaret K Shirra; Karen M Arndt; Martin C Schmidt
Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase.
The Journal of biological chemistry 2008;283(1):222-30.
2008: Joanne S M Kim; Brendan N Lilley; Chao Zhang; Kevan M Shokat; Joshua R Sanes; Mei Zhen
A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation.
Neural development 2008;3():23.
2007: William A Weiss; Stephen Taylor; Kevan M Shokat
Recognizing and exploiting differences between RNAi and small-molecule inhibitors.
Nature chemical biology 2007;3(12):739-44.
2007: Jonathan H Lin; Han Li; Douglas Yasumura; Hannah R Cohen; Chao Zhang; Barbara Panning; Kevan M Shokat; Matthew M LaVail; Peter Walter
IRE1 signaling affects cell fate during the unfolded protein response.
Science (New York, N.Y.) 2007;318(5852):944-9.
2007: Zhan-Heng Qi; Maengseok Song; Melisa J Wallace; Dan Wang; Philip M Newton; Thomas McMahon; Wen-Hai Chou; Chao Zhang; Kevan M Shokat; Robert O Messing
Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits.
The Journal of biological chemistry 2007;282(45):33052-63.
2007: Jennifer L Snead; Matthew Sullivan; Drew M Lowery; Michael S Cohen; Chao Zhang; David H Randle; Jack Taunton; Michael B Yaffe; David O Morgan; Kevan M Shokat
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration.
Chemistry & biology 2007;14(11):1261-72.
2007: Raynard Bateman; Daniel Rauh; Kevan M Shokat
Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct.
Organic & biomolecular chemistry 2007;5(20):3363-7.
2007: Eva Estébanez-Perpiñá; Leggy Arnold; Alexander A Arnold; Phuong Nguyen; Edson Delgado Rodrigues; Ellena Mar; Raynard Bateman; Peter Pallai; Kevan M Shokat; John D Baxter; R Kiplin Guy; Paul Webb; Robert J Fletterick
A surface on the androgen receptor that allosterically regulates coactivator binding.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(41):16074-9.
2007: Madhumita Das; Feng Jiang; Hayla K Sluss; Chao Zhang; Kevan M Shokat; Richard A Flavell; Roger J Davis
Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15759-64.
2007: Zachary A Knight; Jennifer L Garrison; Karina Chan; David S King; Kevan M Shokat
A remodelled protease that cleaves phosphotyrosine substrates.
Journal of the American Chemical Society 2007;129(38):11672-3.
2007: Qi-Wen Fan; Christine K Cheng; Theodore paul nicolaides; Christopher S Hackett; Zachary A Knight; Kevan M Shokat; William A Weiss
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma.
Cancer research 2007;67(17):7960-5.
2007: Jasmina J Allen; Manqing Li; Craig S Brinkworth; Jennifer L Paulson; Dan Wang; Anette Hübner; Wen-Hai Chou; Roger J Davis; Al L Burlingame; Robert O Messing; Carol D Katayama; Stephen M Hedrick; Kevan M Shokat
A semisynthetic epitope for kinase substrates.
Nature methods 2007;4(6):511-6.
2007: Chien-Hui Hung; Laurel Thomas; Carl E Ruby; Katelyn Atkins; Nicholas P Morris; Zachary A Knight; Isabel Scholz; Eric Barklis; Andrew D Weinberg; Kevan M Shokat; Gary Thomas
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.
Cell host & microbe 2007;1(2):121-33.
2007: Elenita I Kanin; Ryan T Kipp; Charles Kung; Matthew Slattery; Agnes Viale; Steven Hahn; Kevan M Shokat; Aseem Z Ansari
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5812-7.
2007: Zachary A Knight; Kevan M Shokat
Chemically targeting the PI3K family.
Biochemical Society transactions 2007;35(Pt 2):245-9.
2007: Jimmy A Blair; Daniel Rauh; Charles Kung; Cai-Hong Yun; Qi-Wen Fan; Haridas Rode; Chao Zhang; Michael J Eck; William A Weiss; Kevan M Shokat
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics.
Nature chemical biology 2007;3(4):229-38.
2007: Stéphane Larochelle; Karl A Merrick; Marie-Emilie Terret; Lara Wohlbold; Nora M Barboza; Chao Zhang; Kevan M Shokat; Prasad V Jallepalli; Robert P Fisher
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Molecular cell 2007;25(6):839-50.
2007: Mark E Burkard; Catherine L Randall; Stéphane Larochelle; Chao Zhang; Kevan M Shokat; Robert P Fisher; Prasad V Jallepalli
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4383-8.
2007: Matthew D Simon; Feixia Chu; Lisa R Racki; Cecile C de la Cruz; Al L Burlingame; Barbara Panning; Geeta J Narlikar; Kevan M Shokat
The site-specific installation of methyl-lysine analogs into recombinant histones.
Cell 2007;128(5):1003-12.
2007: Zachary A Knight; Kevan M Shokat
Chemical genetics: where genetics and pharmacology meet.
Cell 2007;128(3):425-30.
2007: Natalia V Sergina; Megan Rausch; Donghui Wang; Johnny Blair; Byron Hann; Kevan M Shokat; Mark M Moasser
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3.
Nature 2007;445(7126):437-41.
2007: Juraj Gregan; Chao Zhang; Cornelia Rumpf; Lubos Cipak; Zhang Li; Pelin Uluocak; Kim Nasmyth; Kevan M Shokat
Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe.
Nature protocols 2007;2(11):2996-3000.
2007: Zachary A Knight; Morri E Feldman; Andras Balla; Tamas Balla; Kevan M Shokat
A membrane capture assay for lipid kinase activity.
Nature protocols 2007;2(10):2459-66.
2006: Matthew D Simon; Morris E Feldman; Daniel Rauh; Ann E Maris; David E Wemmer; Kevan M Shokat
Structure and properties of a re-engineered homeodomain protein-DNA interface.
ACS chemical biology 2006;1(12):755-60.
2006: Lihong Wan; Chao Zhang; Kevan M Shokat; Nancy M Hollingsworth
Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination.
Genetics 2006;174(4):1767-74.
2006: Balázs Tóth; Andras Balla; Hui Ma; Zachary A Knight; Kevan M Shokat; Tamas Balla
Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi.
The Journal of biological chemistry 2006;281(47):36369-77.
2006: Anja Jaeschke; Maria Karasarides; Juan-Jose Ventura; Anka Ehrhardt; Chao Zhang; Richard A Flavell; Kevan M Shokat; Roger J Davis
JNK2 is a positive regulator of the cJun transcription factor.
Molecular cell 2006;23(6):899-911.
2006: Peter Brodersen; Morten Petersen; Henrik Bjørn Nielsen; Shijiang Zhu; Mari-Anne Newman; Kevan M Shokat; Steffen Rietz; Jane Parker; john mundy
Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4.
The Plant journal : for cell and molecular biology 2006;47(4):532-46.
2006: Alexandra Van Keymeulen; Kit Wong; Zachary A Knight; Cedric Govaerts; Klaus M Hahn; Kevan M Shokat; Henry R Bourne
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.
The Journal of cell biology 2006;174(3):437-45.
2006: Zachary A Knight; Beatriz Gonzalez; Morri E Feldman; Eli R Zunder; David D Goldenberg; Olusegun Williams; Robbie Loewith; David Stokoe; Andras Balla; Balazs Toth; Tamas Balla; William A Weiss; Roger L Williams; Kevan M Shokat
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.
Cell 2006;125(4):733-47.
2006: Qi-Wen Fan; Zachary A Knight; David D Goldenberg; Wei Yu; Keith E Mostov; David Stokoe; Kevan M Shokat; William A Weiss
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Cancer cell 2006;9(5):341-9.
2006: Jasmina J Allen; Kevan M Shokat
Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators.
ACS chemical biology 2006;1(3):139-40.
2006: Christopher M Sturgeon; Zachary A Knight; Kevan M Shokat; Michel Roberge
Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage.
Molecular cancer therapeutics 2006;5(4):885-92.
2006: Charles Kung; Denise M Kenski; Kristin Krukenberg; Hiten D Madhani; Kevan M Shokat
Selective kinase inhibition by exploiting differential pathway sensitivity.
Chemistry & biology 2006;13(4):399-407.
2006: Juan-Jose Ventura; Anette Hübner; Chao Zhang; Richard A Flavell; Kevan M Shokat; Roger J Davis
Chemical genetic analysis of the time course of signal transduction by JNK.
Molecular cell 2006;21(5):701-10.
2006: Lara Wohlbold; Stéphane Larochelle; Jack C-F Liao; Geulah Livshits; Juliet Singer; Kevan M Shokat; Robert P Fisher
The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity.
Cell cycle (Georgetown, Tex.) 2006;5(5):546-54.
2006: Stephen J Juris; Kavita Shah; Kevan M Shokat; Jack E Dixon; Panayiotis O Vacratsis
Identification of otubain 1 as a novel substrate for the Yersinia protein kinase using chemical genetics and mass spectrometry.
FEBS letters 2006;580(1):179-83.
2006: Feng Wei; Guo-Du Wang; Chao Zhang; Kevan M Shokat; Huimin Wang; Joseph Zhuo Tsien; Jason Liauw; Min Zhuo
Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia.
Molecular pain 2006;2():21.
2006: Stéphane Larochelle; Jasmin Batliner; Matthew Gamble; Nora M Barboza; Brian C Kraybill; Justin D Blethrow; Kevan M Shokat; Robert P Fisher
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
Nature structural & molecular biology 2006;13(1):55-62.
2006: Benjamin A Pinsky; Charles Kung; Kevan M Shokat; Sue Biggins
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
Nature cell biology 2006;8(1):78-83.
2005: Noah Dephoure; Russell W Howson; Justin D Blethrow; Kevan M Shokat; Erin K O'Shea
Combining chemical genetics and proteomics to identify protein kinase substrates.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):17940-5.
2005: Denise M Kenski; Chao Zhang; Mark von Zastrow; Kevan M Shokat
Chemical genetic engineering of G protein-coupled receptor kinase 2.
The Journal of biological chemistry 2005;280(41):35051-61.
2005: Katharine E D'Aquino; Fernando Monje-Casas; Jennifer Paulson; Vladimir Reiser; Georgette M Charles; Leslie Lai; Kevan M Shokat; Angelika Amon
The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects.
Molecular cell 2005;19(2):223-34.
2005: Zachary A Knight; Kevan M Shokat
Features of selective kinase inhibitors.
Chemistry & biology 2005;12(6):621-37.
2005: Chao Zhang; Denise M Kenski; Jennifer L Paulson; Arale Bonshtien; Guido Sessa; Janet V Cross; Dennis J Templeton; Kevan M Shokat
A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases.
Nature methods 2005;2(6):435-41.
2005: Michael S Cohen; Chao Zhang; Kevan M Shokat; Jack Taunton
Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
Science (New York, N.Y.) 2005;308(5726):1318-21.
2005: Masahiro Tanaka; Raynard Bateman; Daniel Rauh; Eugeni A Vaisberg; Shyam Ramachandani; Chao Zhang; Kirk Hansen; Al L Burlingame; Jay K Trautman; Kevan M Shokat; Cynthia L Adams
An unbiased cell morphology-based screen for new, biologically active small molecules.
PLoS biology 2005;3(5):e128.
2005: Kevan M Shokat
Chemicals call bacteria, and a new membrane protein machine answers.
Cell 2005;121(2):163-6.
2005: Jasmina J Allen; Scott E Lazerwith; Kevan M Shokat
Bio-orthogonal affinity purification of direct kinase substrates.
Journal of the American Chemical Society 2005;127(15):5288-9.
2005: Peter J Alaimo; Zachary A Knight; Kevan M Shokat
Targeting the gatekeeper residue in phosphoinositide 3-kinases.
Bioorganic & medicinal chemistry 2005;13(8):2825-36.
2005: Xi Chen; Haihong Ye; Rejji Kuruvilla; Narendrakumar Ramanan; Katherine W Scangos; Chao Zhang; Nicolas M Johnson; Pamela M England; Kevan M Shokat; David D Ginty
A chemical-genetic approach to studying neurotrophin signaling.
Neuron 2005;46(1):13-21.
2005: Masafumi Muratani; Charles Kung; Kevan M Shokat; William P Tansey
The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing.
Cell 2005;120(6):887-99.
2005: Charles Kung; Denise M Kenski; Scott H Dickerson; Russell W Howson; Lee F Kuyper; Hiten D Madhani; Kevan M Shokat
Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3587-92.
2005: Charles Kung; Kevan M Shokat
Small-molecule kinase-inhibitor target assessment.
Chembiochem : a European journal of chemical biology 2005;6(3):523-6.
2005: Michele H Jones; Brenda J Huneycutt; Chad Pearson; Chao Zhang; Garry Morgan; Kevan M Shokat; Kerry Bloom; Mark Winey
Chemical genetics reveals a role for Mps1 kinase in kinetochore attachment during mitosis.
Current biology : CB 2005;15(2):160-5.
2004: Stephane Wong; Jami McLaughlin; Donghui Cheng; C Zhang; Kevan M Shokat; Owen N Witte
Sole BCR-ABL inhibition is insufficient to eliminate all myeloproliferative disorder cell populations.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(50):17456-61.
2004: Zachary A Knight; Gary G Chiang; Peter J Alaimo; Denise M Kenski; Caroline B Ho; Kristin Coan; Robert T Abraham; Kevan M Shokat
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold.
Bioorganic & medicinal chemistry 2004;12(17):4749-59.
2004: Dustin J Maly; Jasmina A Allen; Kevan M Shokat
A mechanism-based cross-linker for the identification of kinase-substrate pairs.
Journal of the American Chemical Society 2004;126(30):9160-1.
2004: Eric J Kunkel; Ivan Plavec; Dat Nguyen; Jennifer Melrose; Elen S Rosler; Leon T Kao; Yuker Wang; Evangelos Hytopoulos; Anthony C Bishop; Raynard Bateman; Kevan M Shokat; Eugene C Butcher; Ellen L Berg
Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models.
Assay and drug development technologies 2004;2(4):431-41.
2004: Matthew D Simon; Kevan M Shokat
Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide.
Journal of the American Chemical Society 2004;126(26):8078-9.
2004: Ken Sato; Matthew D Simon; Aron M Levin; Kevan M Shokat; Gregory A Weiss
Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning.
Chemistry & biology 2004;11(7):1017-23.
2004: Justin Blethrow; Chao Zhang; Kevan M Shokat; Eric L. Weiss
Design and use of analog-sensitive protein kinases.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2004;Chapter 18():Unit 18.11.
2004: David Provance, Jr.; Christopher R Gourley; Colleen M Silan; L C Cameron; Kevan M Shokat; James R Goldenring; Kavita Shah; Peter G Gillespie; John A Mercer
Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(7):1868-73.
2004: Ying Liu; Charles Kung; James Fishburn; Aseem Z Ansari; Kevan M Shokat; Steven Hahn
Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.
Molecular and cellular biology 2004;24(4):1721-35.
2004: Alison D Hindley; Sungdae Park; Lily Wang; Kavita Shah; Yanli Wang; Xiche Hu; Kevan M Shokat; Walter Kolch; John M Sedivy; Kam C Yeung
Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position.
FEBS letters 2004;556(1-3):26-34.
2004: Matthew D Simon; Ken Sato; Gregory A Weiss; Kevan M Shokat
A phage display selection of engrailed homeodomain mutants and the importance of residue Q50.
Nucleic acids research 2004;32(12):3623-31.
2004: Lihong Wan; Teresa de los Santos; Chao Zhang; Kevan M Shokat; Nancy M Hollingsworth
Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast.
Molecular biology of the cell 2004;15(1):11-23.
2003: Qi-Wen Fan; Kimberly Musa Specht; Chao Zhang; David D Goldenberg; Kevan M Shokat; William A Weiss
Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach.
Cancer research 2003;63(24):8930-8.
2003: Feroz R Papa; Chao Zhang; Kevan M Shokat; Peter Walter
Bypassing a kinase activity with an ATP-competitive drug.
Science (New York, N.Y.) 2003;302(5650):1533-7.
2003: Jeffrey A Ubersax; Erika L Woodbury; Phuong N Quang; Maria Paraz; Justin D Blethrow; Kavita Shah; Kevan M Shokat; David O Morgan
Targets of the cyclin-dependent kinase Cdk1.
Nature 2003;425(6960):859-64.
2003: Mariko Sekiya-Kawasaki; Aaron Chris Groen; M Jamie T V Cope; Marko Kaksonen; Hadiya A Watson; Chao Zhang; Kevan M Shokat; Beverly Wendland; Kent L McDonald; J Michael McCaffery; David G Drubin
Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis.
The Journal of cell biology 2003;162(5):765-72.
2003: Zachary A Knight; Birgit Schilling; Richard H Row; Denise M Kenski; Bradford W Gibson; Kevan M Shokat
Phosphospecific proteolysis for mapping sites of protein phosphorylation.
Nature biotechnology 2003;21(9):1047-54.
2003: Aparna Sreenivasan; Anthony C Bishop; Kevan M Shokat; Doug R Kellogg
Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events.
Molecular and cellular biology 2003;23(17):6327-37.
2003: Angela Denzel; Katherine J Hare; Chao Zhang; Kevan M Shokat; Eric J Jenkinson; Graham Anderson; Adrian C Hayday
Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):519-23.
2003: Scott M Ulrich; Denise M Kenski; Kevan M Shokat
Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues.
Biochemistry 2003;42(26):7915-21.
2003: Kirsten R Benjamin; Chao Zhang; Kevan M Shokat; Ira Herskowitz
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.
Genes & development 2003;17(12):1524-39.
2003: Scott T. Eblen; N Vinay Kumar; Kavita Shah; Michelle J Henderson; Colin K W Watts; Kevan M Shokat; Michael J Weber
Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.
The Journal of biological chemistry 2003;278(17):14926-35.
2003: Huimin Wang; Eiji Shimizu; Ya-Ping Tang; Min Cho; Maureen Kyin; Wenqi Zuo; Daphne Robinson; Peter J Alaimo; Chao Zhang; Hiromi Morimoto; Min Zhuo; Ruiben Feng; Kevan M Shokat; Joseph Zhuo Tsien
Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4287-92.
2003: Hagai Abeliovich; Chao Zhang; William A Dunn; Kevan M Shokat; Daniel J Klionsky
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy.
Molecular biology of the cell 2003;14(2):477-90.
2003: Kavita Shah; Kevan M Shokat
A chemical genetic approach for the identification of direct substrates of protein kinases.
Methods in molecular biology (Clifton, N.J.) 2003;233():253-71.
2002: Scott M Ulrich; Nathan A Sallee; Kevan M Shokat
Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases.
Bioorganic & medicinal chemistry letters 2002;12(21):3223-7.
2002: Brian C Kraybill; Lisa L Elkin; Justin D Blethrow; David O Morgan; Kevan M Shokat
Inhibitor scaffolds as new allele specific kinase substrates.
Journal of the American Chemical Society 2002;124(41):12118-28.
2002: Eric L. Weiss; Cornelia Kurischko; Chao Zhang; Kevan M Shokat; David G Drubin; Francis C Luca
The Saccharomyces cerevisiae Mob2p-Cbk1p kinase complex promotes polarized growth and acts with the mitotic exit network to facilitate daughter cell-specific localization of Ace2p transcription factor.
The Journal of cell biology 2002;158(5):885-900.
2002: Oleksandr V Buzko; Kevan M Shokat
A kinase sequence database: sequence alignments and family assignment.
Bioinformatics (Oxford, England) 2002;18(9):1274-5.
2002: Qi-Wen Fan; Chao Zhang; Kevan M Shokat; William A Weiss
Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling.
Current biology : CB 2002;12(16):1386-94.
2002: Kevan M Shokat; Mark Velleca
Novel chemical genetic approaches to the discovery of signal transduction inhibitors.
Drug discovery today 2002;7(16):872-9.
2002: Colleen M Niswender; R Wesley Ishihara; Luke M Judge; Chao Zhang; Kevan M Shokat; G Stanley McKnight
Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity.
The Journal of biological chemistry 2002;277(32):28916-22.
2002: Kimberly M Specht; Kevan M Shokat
The emerging power of chemical genetics.
Current opinion in cell biology 2002;14(2):155-9.
2002: Jeffrey R Holt; Susan K H Gillespie; David Provance, Jr.; Kavita Shah; Kevan M Shokat; David P Corey; John A Mercer; Peter G Gillespie
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells.
Cell 2002;108(3):371-81.
2002: Oleksandr V Buzko; Anthony C Bishop; Kevan M Shokat
Modified AutoDock for accurate docking of protein kinase inhibitors.
Journal of computer-aided molecular design 2002;16(2):113-27.
2002: Scott Ulrich; Kevan M Shokat
Green fluorescent protein-based protein kinase biosensor substrates.
Methods in molecular biology (Clifton, N.J.) 2002;183():275-85.
2002: Kavita Shah; Kevan M Shokat
A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway.
Chemistry & biology 2002;9(1):35-47.
2002: Laurie A Witucki; Xin Huang; Kavita Shah; Yi Liu; Saw Kyin; Michael J Eck; Kevan M Shokat
Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme.
Chemistry & biology 2002;9(1):25-33.
2001: Adam S Carroll; A C Bishop; Joe L DeRisi; Kevan M Shokat; Erin K O'Shea
Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12578-83.
2001: Peter J Alaimo; M A Shogren-Knaak; Kevan M Shokat
Chemical genetic approaches for the elucidation of signaling pathways.
Current opinion in chemical biology 2001;5(4):360-7.
2001: Stephan Schauder; Kevan M Shokat; Michael Surette; Bonnie L Bassler
The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule.
Molecular microbiology 2001;41(2):463-76.
2001: Hasem Habelhah; K Shah; L Huang; Al L Burlingame; Kevan M Shokat; Ze'ev Ronai
Identification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.
The Journal of biological chemistry 2001;276(21):18090-5.
2001: Anthony C Bishop; Oleksandr V Buzko; Kevan M Shokat
Magic bullets for protein kinases.
Trends in cell biology 2001;11(4):167-72.
2001: Hasem Habelhah; Keerti V Shah; L Huang; A Ostareck-Lederer; Al L Burlingame; Kevan M Shokat; M W Hentze; Ze'ev Ronai
ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.
Nature cell biology 2001;3(3):325-30.
2001: A Y Ting; K Witte; K Shah; Brian C Kraybill; Kevan M Shokat; P G Schultz
Phage-display evolution of tyrosine kinases with altered nucleotide specificity.
Biopolymers 2001;60(3):220-8.
2001: M A Shogren-Knaak; Peter J Alaimo; Kevan M Shokat
Recent advances in chemical approaches to the study of biological systems.
Annual review of cell and developmental biology 2001;17():405-33.
2000: Yi Liu; Laurie A Witucki; Kavita Shah; AC Bishop; Kevan M Shokat
Src-Abl tyrosine kinase chimeras: replacement of the adenine binding pocket of c-Abl with v-Src to swap nucleotide and inhibitor specificities.
Biochemistry 2000;39(47):14400-8.
2000: Eric L. Weiss; A C Bishop; Kevan M Shokat; David G Drubin
Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p.
Nature cell biology 2000;2(10):677-85.
2000: AC Bishop; Jeffrey A Ubersax; D T Petsch; Dina Matheos; Nathanael S Gray; Justin D Blethrow; Eiji Shimizu; Joseph Zhuo Tsien; Peter G Schultz; Mark D Rose; J L Wood; David O Morgan; Kevan M Shokat
A chemical switch for inhibitor-sensitive alleles of any protein kinase.
Nature 2000;407(6802):395-401.
2000: BC Weintraub; Jesse E Jun; A C Bishop; Kevan M Shokat; M L Thomas; Christopher C Goodnow
Entry of B cell receptor into signaling domains is inhibited in tolerant B cells.
The Journal of experimental medicine 2000;191(8):1443-8.
2000: A Bishop; Oleksandr V Buzko; S Heyeck-Dumas; I Jung; Brian C Kraybill; Yi Liu; Kavita Shah; S Ulrich; Laurie A Witucki; F Yang; C Zhang; Kevan M Shokat
Unnatural ligands for engineered proteins: new tools for chemical genetics.
Annual review of biophysics and biomolecular structure 2000;29():577-606.
1999: Peter G Gillespie; Susan K H Gillespie; John A Mercer; Kavita Shah; Kevan M Shokat
Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs.
The Journal of biological chemistry 1999;274(44):31373-81.
1999: Oleksandr V Buzko; Kevan M Shokat
Blocking HIV entry.
Nature structural biology 1999;6(10):906-8.
1999: Yi Liu; A Bishop; Laurie A Witucki; Brian C Kraybill; Eiji Shimizu; Joseph Zhuo Tsien; Jeffrey A Ubersax; Justin D Blethrow; David O Morgan; Kevan M Shokat
Structural basis for selective inhibition of Src family kinases by PP1.
Chemistry & biology 1999;6(9):671-8.
1999: AC Bishop; Kevan M Shokat
Acquisition of inhibitor-sensitive protein kinases through protein design.
Pharmacology & therapeutics 1999;82(2-3):337-46.
1999: F Yang; Yi Liu; S D Bixby; J D Friedman; Kevan M Shokat
Highly efficient green fluorescent protein-based kinase substrates.
Analytical biochemistry 1999;266(2):167-73.
1998: Yi Liu; Kavita Shah; F Yang; Laurie A Witucki; Kevan M Shokat
A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src.
Bioorganic & medicinal chemistry 1998;6(8):1219-26.
1998: Thomas Surrey; Michael B Elowitz; PE Wolf; F Yang; François Nédélec; Kevan M Shokat; Stanislas Leibler
Chromophore-assisted light inactivation and self-organization of microtubules and motors.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4293-8.
1998: AC Bishop; Kavita Shah; Yi Liu; Laurie A Witucki; C Kung; Kevan M Shokat
Design of allele-specific inhibitors to probe protein kinase signaling.
Current biology : CB 1998;8(5):257-66.
1998: Yi Liu; Kavita Shah; F Yang; Laurie A Witucki; Kevan M Shokat
Engineering Src family protein kinases with unnatural nucleotide specificity.
Chemistry & biology 1998;5(2):91-101.
1997: Kavita Shah; Yi Liu; C Deirmengian; Kevan M Shokat
Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3565-70.
1996: Roland S Liblau; Roland Tisch; Kevan M Shokat; X Yang; N Dumont; Christopher C Goodnow; Hugh McDevitt
Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(7):3031-6.
1995: Kevan M Shokat
Tyrosine kinases: modular signaling enzymes with tunable specificities.
Chemistry & biology 1995;2(8):509-14.
1995: Kevan M Shokat; Christopher C Goodnow
Antigen-induced B-cell death and elimination during germinal-centre immune responses.
Nature 1995;375(6529):334-8.
1995: Christopher C Goodnow; Jason G Cyster; S B Hartley; S E Bell; M P Cooke; James I Healy; Srinivas Akkaraju; Jeffrey C Rathmell; S L Pogue; Kevan M Shokat
Self-tolerance checkpoints in B lymphocyte development.
Advances in immunology 1995;59():279-368.
1994: Roland S Liblau; CI Pearson; Kevan M Shokat; Roland Tisch; XD Yang; Hugh McDevitt
High-dose soluble antigen: peripheral T-cell proliferation or apoptosis.
Immunological reviews 1994;142():193-208.
1994: M P Cooke; A W Heath; Kevan M Shokat; Y Zeng; F D Finkelman; Peter Linsley; M Howard; Christopher C Goodnow
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells.
The Journal of experimental medicine 1994;179(2):425-38.
1991: Kevan M Shokat; Peter G Schultz
The generation of antibody combining sites containing catalytic residues.
Ciba Foundation symposium 1991;159():118-28; discussion 128-34.
1991: Kevan M Shokat; Peter G Schultz
Catalytic antibodies.
Methods in enzymology 1991;203():327-51.
1990: Kevan M Shokat; Peter G Schultz
Catalytic antibodies.
Annual review of immunology 1990;8():335-63.
1989: Kevan M Shokat; C J Leumann; R Sugasawara; Peter G Schultz
A new strategy for the generation of catalytic antibodies.
Nature 1989;338(6212):269-71.
1987: R W McClard; Kevan M Shokat
Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model.
Biochemistry 1987;26(12):3378-84.