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Henry Showell

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Ronald P Gladue; Laurie A Tylaska; William H Brissette; Paul D Lira; John C Kath; Christopher S Poss; Matthew F Brown; Timothy J Paradis; Maryrose Conklyn; Kevin Ogborne; Molly A McGlynn; Brett M Lillie; Amy P DiRico; Erin N Mairs; Eric B McElroy; William Martin; Ingrid A Stock; Richard M Shepard; Henry J Showell; Kuldeep S Neote
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.
Anthony J Milici; Lauren A Carroll; Hans A Stukenbrok; A K Shay; Ronald P Gladue; Henry J Showell
Early eosinophil infiltration into the optic nerve of mice with experimental allergic encephalomyelitis.
Lawrence A Reiter; K Koch; Anthony D Piscopio; Henry J Showell; R Alpert; M S Biggers; R J Chambers; Maryrose Conklyn; K Cooper; Santo R Cortina; J N Dibrino; B W Dominy; C A Farrell; Gary Hingorani; Gary J Martinelli; M Ramchandani; K F Wright
trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.

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All Publications

2003: Ronald P Gladue; Laurie A Tylaska; William H Brissette; Paul D Lira; John C Kath; Christopher S Poss; Matthew F Brown; Timothy J Paradis; Maryrose Conklyn; Kevin Ogborne; Molly A McGlynn; Brett M Lillie; Amy P DiRico; Erin N Mairs; Eric B McElroy; William Martin; Ingrid A Stock; Richard M Shepard; Henry J Showell; Kuldeep S Neote
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.
The Journal of biological chemistry 2003;278(42):40473-80.
1998: Anthony J Milici; Lauren A Carroll; Hans A Stukenbrok; A K Shay; Ronald P Gladue; Henry J Showell
Early eosinophil infiltration into the optic nerve of mice with experimental allergic encephalomyelitis.
Laboratory investigation; a journal of technical methods and pathology 1998;78(10):1239-44.
1998: Lawrence A Reiter; K Koch; Anthony D Piscopio; Henry J Showell; R Alpert; M S Biggers; R J Chambers; Maryrose Conklyn; K Cooper; Santo R Cortina; J N Dibrino; B W Dominy; C A Farrell; Gary Hingorani; Gary J Martinelli; M Ramchandani; K F Wright
trans-3-Benzyl-4-hydroxy-7-chromanylbenzoic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor.
Bioorganic & medicinal chemistry letters 1998;8(14):1781-6.
1998: Henry J Showell; Maryrose Conklyn; R Alpert; Gary Hingorani; K F Wright; MA Smith; EJ Stam; Eben D Salter; DN Scampoli; S Meltzer; Lawrence A Reiter; K Koch; Anthony D Piscopio; Santo R Cortina; Arturo Lopez-Anaya; ER Pettipher; Anthony J Milici; Richard J Griffiths
The preclinical pharmacological profile of the potent and selective leukotriene B4 antagonist CP-195543.
The Journal of pharmacology and experimental therapeutics 1998;285(3):946-54.
1998: T E Liston; Maryrose Conklyn; J Houser; Keith Wilner; A Johnson; Glen Apseloff; C Whitacre; Henry J Showell
Pharmacokinetics and pharmacodynamics of the leukotriene B4 receptor antagonist CP-105,696 in man following single oral administration.
British journal of clinical pharmacology 1998;45(2):115-21.
1997: John B Cheng; John W Watson; Chistopher Pazoles; James D Eskra; Richard J Griffiths; Victoria L Cohan; Claudia R Turner; Henry J Showell; ER Pettipher
The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy.
The Journal of pharmacology and experimental therapeutics 1997;280(2):621-6.
1997: Maryrose Conklyn; Henry J Showell
Biological activity C-X-C and C-C chemokines on leukocyte subpopulations in human whole blood.
Methods in enzymology 1997;287():378-87.
1996: Maryrose Conklyn; Kuldeep S Neote; Henry J Showell
Chemokine-dependent upregulation of CD11b on specific leukocyte subpopulations in human whole blood: effect of anticoagulant on rantes and MIP-1 beta stimulation.
Cytokine 1996;8(10):762-6.
1996: Victoria L Cohan; Henry J Showell; D A Fisher; Chistopher Pazoles; John W Watson; Claudia R Turner; John B Cheng
In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1356-61.
1996: Claudia R Turner; Victoria L Cohan; John B Cheng; Henry J Showell; Chistopher Pazoles; John W Watson
The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1349-55.
1996: M Mansour; M Karmilowicz; S J Hawrylik; B Nalcerio; J Angilly; Maryrose Conklyn; C M Lilly; J M Drazen; S E Lee; D D Auperin; J R De Wet; Victoria L Cohan; Henry J Showell; dennis danley
Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells.
The American journal of physiology 1996;270(6 Pt 1):L1002-7.
1996: Ronald P Gladue; L A Carroll; Anthony J Milici; D N Scampoli; H A Stukenbrok; ER Pettipher; E D Salter; L Contillo; Henry J Showell
Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.
The Journal of experimental medicine 1996;183(4):1893-8.
1996: Henry J Showell; R Breslow; Maryrose Conklyn; G P Hingorani; K Koch
Characterization of the pharmacological profile of the potent LTB4 antagonist CP-105,696 on murine LTB4 receptors in vitro.
British journal of pharmacology 1996;117(6):1127-32.
1996: Claudia R Turner; R Breslow; Maryrose Conklyn; C J Andresen; D K Patterson; Arturo Lopez-Anaya; B Owens; P Lee; John W Watson; Henry J Showell
In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma.
The Journal of clinical investigation 1996;97(2):381-7.
1995: C R Bozic; L F Kolakowski; Norma P Gerard; C Garcia-Rodriguez; C von Uexkull-Guldenband; Maryrose Conklyn; R Breslow; Henry J Showell; C Gerard
Expression and biologic characterization of the murine chemokine KC.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(11):6048-57.
1995: Henry J Showell; ER Pettipher; John B Cheng; R Breslow; Maryrose Conklyn; C A Farrell; G P Hingorani; E D Salter; B C Hackman; D J Wimberly
The in vitro and in vivo pharmacologic activity of the potent and selective leukotriene B4 receptor antagonist CP-105696.
The Journal of pharmacology and experimental therapeutics 1995;273(1):176-84.
1995: Stephen Peiper; Zixuan Wang; Kuldeep S Neote; Alvin W Martin; Henry J Showell; Maryrose Conklyn; K Ogborne; Terence Hadley; Z H Lu; Joseph Hesselgesser; Richard Horuk
The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.
The Journal of experimental medicine 1995;181(4):1311-7.
1995: P A McNiff; C Stewart; J Sullivan; Henry J Showell; Christopher A Gabel
Synovial fluid from rheumatoid arthritis patients contains sufficient levels of IL-1 beta and IL-6 to promote production of serum amyloid A by Hep3B cells.
Cytokine 1995;7(2):209-19.
1994: C R Bozic; Norma P Gerard; C von Uexkull-Guldenband; L F Kolakowski; Maryrose Conklyn; R Breslow; Henry J Showell; C Gerard
The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.
The Journal of biological chemistry 1994;269(47):29355-8.
1994: K Koch; L S Melvin; Lawrence A Reiter; M S Biggers; Henry J Showell; Richard J Griffiths; ER Pettipher; John B Cheng; Anthony J Milici; R Breslow
(+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxychroman-7-yl]cyclopentane carboxylic acid, a highly potent, selective leukotriene B4 antagonist with oral activity in the murine collagen-induced arthritis model.
Journal of medicinal chemistry 1994;37(20):3197-9.
1994: ER Pettipher; E D Salter; Henry J Showell
Effect of in vivo desensitization to leukotriene B4 on eosinophil infiltration in response to C5a in guinea-pig skin.
British journal of pharmacology 1994;113(1):117-20.
1994: S Richard; Andrey S Shaw; Henry J Showell; P A Connelly
The role of individual Fc gamma receptors in aggregated IgG-stimulated protein tyrosine phosphorylation in the human neutrophil.
Biochemical and biophysical research communications 1994;199(2):653-61.
1994: S Richard; C A Farrell; Andrey S Shaw; Henry J Showell; P A Connelly
C5a as a model for chemotactic factor-stimulated tyrosine phosphorylation in the human neutrophil.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2479-87.
1994: Neal Pinckard; D S Woodard; Henry J Showell; Maryrose Conklyn; M J Novak; Linda McManus
Structural and (patho)physiological diversity of PAF.
Clinical reviews in allergy 1994;12(4):329-59.
1993: ER Pettipher; E D Salter; R Breslow; L Raycroft; Henry J Showell
Specific inhibition of leukotriene B4 (LTB4)-induced neutrophil emigration by 20-hydroxy LTB4: implications for the regulation of inflammatory responses.
British journal of pharmacology 1993;110(1):423-7.
1993: John B Cheng; JS Pillar; John T Shirley; Henry J Showell; John W Watson; Victoria L Cohan
Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid.
The Journal of pharmacology and experimental therapeutics 1993;264(2):922-9.
1992: Neal Pinckard; Henry J Showell; R Castillo; C Lear; R Breslow; Linda McManus; D S Woodard; J C Ludwig
Differential responsiveness of human neutrophils to the autocrine actions of 1-O-alkyl-homologs and 1-acyl analogs of platelet-activating factor.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3528-35.
1991: P A Connelly; C A Farrell; J M Merenda; Maryrose Conklyn; Henry J Showell
Tyrosine phosphorylation is an early signaling event common to Fc receptor crosslinking in human neutrophils and rat basophilic leukemia cells (RBL-2H3).
Biochemical and biophysical research communications 1991;177(1):192-201.
1990: John B Cheng; JS Pillar; Maryrose Conklyn; R Breslow; John T Shirley; Henry J Showell
Evidence that peptidoleukotriene is a prerequisite for antigen-dependent thromboxane synthesis in IgG1-passively sensitized guinea pig lungs.
The Journal of pharmacology and experimental therapeutics 1990;255(2):664-71.
1990: John W Watson; Maryrose Conklyn; Henry J Showell
IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators.
The American review of respiratory disease 1990;142(5):1093-8.
1990: G Conyers; L Milks; M Conklyn; Henry J Showell; E Cramer
A factor in serum lowers resistance and opens tight junctions of MDCK cells.
The American journal of physiology 1990;259(4 Pt 1):C577-85.
1990: Maryrose Conklyn; S B Kadin; Henry J Showell
Inhibition of IgE-mediated N-acetylglucosaminidase and serotonin release from rat basophilic leukemia cells (RBL-2H3) by tenidap: a novel anti-inflammatory agent.
International archives of allergy and applied immunology 1990;91(4):369-73.
1990: John B Cheng; JS Pillar; Maryrose Conklyn; R Breslow; John T Shirley; N P Gerard; Henry J Showell
Antigen-dependent leukotriene synthesis and histamine release from IgG1 passively-sensitized guinea pig lungs ex vivo: relationship between serum levels of antigen-specific IgG1 and mediator synthesis/release.
Pulmonary pharmacology 1990;3(4):171-9.
1989: John B Cheng; JS Pillar; Maryrose Conklyn; R Breslow; John T Shirley; Henry J Showell
Involvement of peptidoleukotrienes in antigen-dependent thromboxane (TX) synthesis in IgG1-sensitized guinea pig lungs.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():187-90.