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Ke Shuai

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TOP 3
Chris Schindler; Ke Shuai; Vincent R Prezioso; James E Darnell
Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.
Bin Liu; Samuel Tahk; Kathleen M Yee; Guoping Fan; Ke Shuai
The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
Bin Liu; Ke Shuai
Summon SUMO to wrestle with inflammation.

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All Publications

2011: Chris Schindler; Ke Shuai; Vincent R Prezioso; James E Darnell
Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):5489-94.
2010: Bin Liu; Samuel Tahk; Kathleen M Yee; Guoping Fan; Ke Shuai
The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression.
Science (New York, N.Y.) 2010;330(6003):521-5.
2009: Bin Liu; Ke Shuai
Summon SUMO to wrestle with inflammation.
Molecular cell 2009;35(6):731-2.
2008: Bin Liu; Ke Shuai
Targeting the PIAS1 SUMO ligase pathway to control inflammation.
Trends in pharmacological sciences 2008;29(10):505-9.
2008: Bin Liu; Ke Shuai
Regulation of the sumoylation system in gene expression.
Current opinion in cell biology 2008;20(3):288-93.
2008: Meelad M Dawlaty; Liviu Malureanu; Karthik B Jeganathan; Esther Kao; Claudio Sustmann; Samuel Tahk; Ke Shuai; Rudolf Grosschedl; Jan M A van Deursen
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Cell 2008;133(1):103-15.
2007: Aryaman Shalizi; Parizad M Bilimoria; Judith Stegmüller; Brice Gaudillière; Yue Yang; Ke Shuai; Azad Bonni
PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(37):10037-46.
2007: Samuel Tahk; Bin Liu; Vasili Chernishof; Kelly A Wong; Hong Wu; Ke Shuai
Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11643-8.
2007: Bin Liu; Yonghui Yang; Vasili Chernishof; Rachel R Ogorzalek Loo; Hyunduk Jang; Samuel Tahk; Randy Yang; Sheldon Mink; David Shultz; Clifford J Bellone; Joseph A Loo; Ke Shuai
Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
Cell 2007;129(5):903-14.
2007: Shrikrishna Dadke; Sophie Cotteret; Shu-Chin Yip; Zahara M Jaffer; Fawaz G Haj; Alexey Ivanov; Frank Rauscher; Ke Shuai; Tony Ng; Benjamin G Neel; Jonathan Chernoff
Regulation of protein tyrosine phosphatase 1B by sumoylation.
Nature cell biology 2007;9(1):80-5.
2006: Oxana A Malakhova; Keun Il Kim; Jiann-Kae Luo; Weiguo Zou; K G Suresh Kumar; Serge Y Fuchs; Ke Shuai; Dong-Er Zhang
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
The EMBO journal 2006;25(11):2358-67.
2006: Ke Shuai
Regulation of cytokine signaling pathways by PIAS proteins.
Cell research 2006;16(2):196-202.
2005: Ke Shuai; Bin Liu
Regulation of gene-activation pathways by PIAS proteins in the immune system.
Nature reviews. Immunology 2005;5(8):593-605.
2005: Guoping Fan; Keri Martinowich; Mark Chin; Fei He; Shaun D Fouse; Leah Hutnick; Daisuke Hattori; Weihong Ge; Yin Shen; Hao Wu; Johanna ten Hoeve; Ke Shuai; Yi E Sun
DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.
Development (Cambridge, England) 2005;132(15):3345-56.
2005: Minghao Zhong; Melissa A Henriksen; Kenji Takeuchi; Olaf Schaefer; Bin Liu; Johanna ten Hoeve; Zhiyong Ren; Xiang Mao; Xiaomin Chen; Ke Shuai; James E Darnell
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):3966-71.
2005: Bin Liu; Randy Yang; Kelly A Wong; Crescent Getman; Natalie Stein; Michael A Teitell; Genhong Cheng; Hong Wu; Ke Shuai
Negative regulation of NF-kappaB signaling by PIAS1.
Molecular and cellular biology 2005;25(3):1113-23.
2004: Bin Liu; Sheldon Mink; Kelly A Wong; Natalie Stein; Crescent Getman; Paul W Dempsey; Hong Wu; Ke Shuai
PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity.
Nature immunology 2004;5(9):891-8.
2004: Mitchell Gross; Randy Yang; Irina Top; Christina Gasper; Ke Shuai
PIASy-mediated repression of the androgen receptor is independent of sumoylation.
Oncogene 2004;23(17):3059-66.
2003: Ke Shuai
Serine phosphorylation: arming Stat1 against infection.
Immunity 2003;19(6):771-2.
2003: Ke Shuai; Bin Liu
Regulation of JAK-STAT signalling in the immune system.
Nature reviews. Immunology 2003;3(11):900-11.
2003: Jianyin Long; Isao Matsuura; Dongming He; Guannan Wang; Ke Shuai; Fang Liu
Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9791-6.
2003: Taruna Arora; Bin Liu; Hongchin He; Jenny Kim; Theresa L Murphy; Kenneth M Murphy; Robert L Modlin; Ke Shuai
PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.
The Journal of biological chemistry 2003;278(24):21327-30.
2003: Oxana A Malakhova; Ming Yan; Michael P Malakhov; Youzhong Yuan; Kenneth J Ritchie; Keun Il Kim; Luke Peterson; Ke Shuai; Dong-Er Zhang
Protein ISGylation modulates the JAK-STAT signaling pathway.
Genes & development 2003;17(4):455-60.
2002: Johanna ten Hoeve; Maria de Jesus Ibarra-Sanchez; Yubin Fu; Wei Zhu; Michel Tremblay; Michael David; Ke Shuai
Identification of a nuclear Stat1 protein tyrosine phosphatase.
Molecular and cellular biology 2002;22(16):5662-8.
2001: Bin Liu; Ke Shuai
Induction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activation.
The Journal of biological chemistry 2001;276(39):36624-31.
2001: Jenny Kim; K Uyemura; M K Van Dyke; Annaliza J Legaspi; Thomas H Rea; Ke Shuai; Robert L Modlin
A role for IL-12 receptor expression and signal transduction in host defense in leprosy.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(2):779-86.
2001: Mitchell Gross; Bin Liu; Jiann-an Tan; Frank S French; M Carey; Ke Shuai
Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells.
Oncogene 2001;20(29):3880-7.
2001: Bin Liu; Mitchell Gross; Johanna ten Hoeve; Ke Shuai
A transcriptional corepressor of Stat1 with an essential LXXLL signature motif.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3203-7.
2001: Kerri A Mowen; J Tang; W Zhu; Brandon T Schurter; Ke Shuai; harvey Herschman; Michael David
Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.
Cell 2001;104(5):731-41.
2000: B Rödel; K Tavassoli; Holger Karsunky; Thorsten Schmidt; M Bachmann; F Schaper; P Heinrich; Ke Shuai; Hans-Peter Elsässer; Tarik Möröy
The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.
The EMBO journal 2000;19(21):5845-55.
2000: Ke Shuai
Modulation of STAT signaling by STAT-interacting proteins.
Oncogene 2000;19(21):2638-44.
2000: J Liao; Y Fu; Ke Shuai
Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5267-72.
2000: Thomas G Graeber; Ke Shuai
Rapid gene repression triggered by interleukin-6 at the onset of monocyte differentiation.
Biochemical and biophysical research communications 2000;267(3):863-9.
2000: Jiann-an Tan; Susan H Hall; Katherine G Hamil; Gail Grossman; Peter Petrusz; J Liao; Ke Shuai; Frank S French
Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis.
Molecular endocrinology (Baltimore, Md.) 2000;14(1):14-26.
1999: Ke Shuai
The STAT family of proteins in cytokine signaling.
Progress in biophysics and molecular biology 1999;71(3-4):405-22.
1998: M M Song; Ke Shuai
The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities.
The Journal of biological chemistry 1998;273(52):35056-62.
1998: Bin Liu; J Liao; X Rao; S A Kushner; CD Chung; David D Chang; Ke Shuai
Inhibition of Stat1-mediated gene activation by PIAS1.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10626-31.
1998: VE García; D Jullien; M Song; K Uyemura; Ke Shuai; Craig Morita; Robert L Modlin
IL-15 enhances the response of human gamma delta T cells to nonpeptide [correction of nonpetide] microbial antigens.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(9):4322-9.
1997: CD Chung; J Liao; Bin Liu; X Rao; Philippe Jay; Philippe Berta; Ke Shuai
Specific inhibition of Stat3 signal transduction by PIAS3.
Science (New York, N.Y.) 1997;278(5344):1803-5.
1996: Ke Shuai; J Liao; M M Song
Enhancement of antiproliferative activity of gamma interferon by the specific inhibition of tyrosine dephosphorylation of Stat1.
Molecular and cellular biology 1996;16(9):4932-41.
1996: Ke Shuai; J Halpern; J ten Hoeve; X Rao; Charles L Sawyers
Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia.
Oncogene 1996;13(2):247-54.
1994: C K Jiang; S Flanagan; M Ohtsuki; Ke Shuai; Irwin M Freedberg; Miroslav Blumenberg
Disease-activated transcription factor: allergic reactions in human skin cause nuclear translocation of STAT-91 and induce synthesis of keratin K17.
Molecular and cellular biology 1994;14(7):4759-69.
1994: Ke Shuai
Interferon-activated signal transduction to the nucleus.
Current opinion in cell biology 1994;6(2):253-9.
1994: Ke Shuai; Curt M Horvath; L H Huang; S A Qureshi; David Cowburn; James E Darnell
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions.
Cell 1994;76(5):821-8.
1993: Ke Shuai; Andrew Ziemiecki; Andrew Wilks; A G Harpur; H B Sadowski; M Gilman; James E Darnell
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins.
Nature 1993;366(6455):580-3.
1993: H B Sadowski; Ke Shuai; James E Darnell; M Gilman
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors.
Science (New York, N.Y.) 1993;261(5129):1739-44.
1993: Ke Shuai; George R Stark; Ian M Kerr; James E Darnell
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
Science (New York, N.Y.) 1993;261(5129):1744-6.
1993: K D Khan; Ke Shuai; G Lindwall; Stephen E Maher; J E Darnell; Alfred L M Bothwell
Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6806-10.
1993: R N Pearse; R Feinman; Ke Shuai; J E Darnell; Jeffrey V Ravetch
Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4314-8.
1992: Ke Shuai; Christian Schindler; Vincent Prezioso; James E Darnell
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.
Science (New York, N.Y.) 1992;258(5089):1808-12.
1992: Christian Schindler; Ke Shuai; Vincent Prezioso; James E Darnell
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.
Science (New York, N.Y.) 1992;257(5071):809-13.
1992: Ke Shuai; C K Das Gupta; R Scott Hawley; J W Chase; K L Stone; Kenneth R Williams
Purification and characterization of an endo-exonuclease from adult flies of Drosophila melanogaster.
Nucleic acids research 1992;20(6):1379-85.
1991: Ke Shuai; Jonathan R Warner
A temperature sensitive mutant of Saccharomyces cerevisiae defective in pre-rRNA processing.
Nucleic acids research 1991;19(18):5059-64.