Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

Tom Blundell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Procedures

Chemicals & Drugs

Phenomena

Activities & Behaviors

Physiology

Protein Folding

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
25
Chirgadze, Dimitri
25
Cooper, Jonathan
22
Wood, Steve
21
Dhanaraj, Venugopal
18
Abell, Chris
16
burke, david
15
Sibanda, Bancinyane
15
Mizuguchi, Kenji
13
Pellegrini, Luca
13
Smith, Alison
11
Sali, Andrej
11
Harmer, Nicholas
10
de Bakker, Paul
10
Deane, CM
10
Pitts, JE

Sign-in to see all Coauthors

Publications

TOP 3
Higueruelo Alícia P; Schreyer Adrian; Bickerton G Richard J; Pitt Will R; Groom Colin R; Blundell Tom L
Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database.
Worth Catherine L; Gong Sungsam; Blundell Tom L
Structural and functional constraints in the evolution of protein families.
Forman Julia R; Worth Catherine L; Bickerton G Richard J; Eisen Tim G; Blundell Tom L
Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Tom Blundell (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Higueruelo Alícia P; Schreyer Adrian; Bickerton G Richard J; Pitt Will R; Groom Colin R; Blundell Tom L
Atomic interactions and profile of small molecules disrupting protein-protein interfaces: the TIMBAL database.
Chemical biology & drug design 2009;74(5):457-67.
2009: Worth Catherine L; Gong Sungsam; Blundell Tom L
Structural and functional constraints in the evolution of protein families.
Nature reviews. Molecular cell biology 2009;10(10):709-20.
2009: Forman Julia R; Worth Catherine L; Bickerton G Richard J; Eisen Tim G; Blundell Tom L
Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis.
Proteins 2009;77(1):84-96.
2009: Gong Sungsam; Worth Catherine L; Bickerton G Richard J; Lee Semin; Tanramluk Duangrudee; Blundell Tom L
Structural and functional restraints in the evolution of protein families and superfamilies.
Biochemical Society transactions 2009;37(Pt 4):727-33.
2009: Lee Semin; Blundell Tom L
Ulla: a program for calculating environment-specific amino acid substitution tables.
Bioinformatics (Oxford, England) 2009;25(15):1976-7.
2009: Tanramluk Duangrudee; Schreyer Adrian; Pitt William R; Blundell Tom L
On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine.
Chemical biology & drug design 2009;74(1):16-24.
2009: Truman Andrew W; Dias Marcio V B; Wu Shu; Blundell Tom L; Huang Fanglu; Spencer Jonathan B
Chimeric glycosyltransferases for the generation of hybrid glycopeptides.
Chemistry & biology 2009;16(6):676-85.
2009: Lee Semin; Blundell Tom L
BIPA: a database for protein-nucleic acid interaction in 3D structures.
Bioinformatics (Oxford, England) 2009;25(12):1559-60.
2009: Worth Catherine L; Blundell Tom L
Satisfaction of hydrogen-bonding potential influences the conservation of polar sidechains.
Proteins 2009;75(2):413-29.
2009: Karmali Anjum M; Blundell Tom L; Furnham Nicholas
Model-building strategies for low-resolution X-ray crystallographic data.
Acta crystallographica. Section D, Biological crystallography 2009;65(Pt 2):121-7.
2009: Bolanos-Garcia Victor M; Kiyomitsu Tomomi; D'Arcy Sheena; Chirgadze Dimitri Y; Grossmann J Günter; Matak-Vinkovic Dijana; Venkitaraman Ashok R; Yanagida Mitsuhiro; Robinson Carol V; Blundell Tom L
The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores.
Structure (London, England : 1993) 2009;17(1):105-16.
2009: Hung Alvin W; Silvestre H Leonardo; Wen Shijun; Ciulli Alessio; Blundell Tom L; Abell Chris
Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
Angewandte Chemie (International ed. in English) 2009;48(45):8452-6.
2008: Montalvao Rinaldo W; Cavalli Andrea; Salvatella Xavier; Blundell Tom L; Vendruscolo Michele
Structure determination of protein-protein complexes using NMR chemical shifts: case of an endonuclease colicin-immunity protein complex.
Journal of the American Chemical Society 2008;130(47):15990-6.
2008: Ciulli Alessio; Scott Duncan E; Ando Michiyo; Reyes Fernando; Saldanha S Adrian; Tuck Kellie L; Chirgadze Dimitri Y; Blundell Tom L; Abell Chris
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
Chembiochem : a European journal of chemical biology 2008;9(16):2606-11.
2008: Núñez Miguel R; Sanders J; Chirgadze D Y; Blundell T L; Furmaniak J; Rees Smith B
FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity.
Journal of molecular endocrinology 2008;41(3):145-64.
2008: Goodger Sarah J; Robinson Christopher J; Murphy Kevin J; Gasiunas Nijole; Harmer Nicholas J; Blundell Tom L; Pye David A; Gallagher John T
Evidence that heparin saccharides promote FGF2 mitogenesis through two distinct mechanisms.
The Journal of biological chemistry 2008;283(19):13001-8.
2008: Li Yi; Chirgadze Dimitri Y; Bolanos-Garcia Victor M; Sibanda Bancinyane L; Davies Owen R; Ahnesorg Peter; Jackson Stephen P; Blundell Tom L
Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ.
The EMBO journal 2008;27(1):290-300.
2008: Cheng Tammy M K; Blundell Tom L; Fernandez-Recio Juan
Structural assembly of two-domain proteins by rigid-body docking.
BMC bioinformatics 2008;9():441.
2008: Gong Sungsam; Blundell Tom L
Discarding functional residues from the substitution table improves predictions of active sites within three-dimensional structures.
PLoS computational biology 2008;4(10):e1000179.
2008: Cheng Tammy M K; Lu Yu-En; Vendruscolo Michele; Lio' Pietro; Blundell Tom L
Prediction by graph theoretic measures of structural effects in proteins arising from non-synonymous single nucleotide polymorphisms.
PLoS computational biology 2008;4(7):e1000135.
2008: Furnham Nicholas; de Bakker Paul Iw; Gore Swanand; Burke David F; Blundell Tom L
Comparative modelling by restraint-based conformational sampling.
BMC structural biology 2008;8():7.
2007: Worth Catherine L; Bickerton G Richard J; Schreyer Adrian; Forman Julia R; Cheng Tammy M K; Lee Semin; Gong Sungsam; Burke David F; Blundell Tom L
A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.
Journal of bioinformatics and computational biology 2007;5(6):1297-318.
2007: Blundell Tom
New dimensions of structural proteomics: exploring chemical and biological space.
Structure (London, England : 1993) 2007;15(11):1342-3.
2007: King Jerry D; Harmer Nicholas J; Preston Andrew; Palmer Colin M; Rejzek Martin; Field Robert A; Blundell Tom L; Maskell Duncan J
Predicting protein function from structure--the roles of short-chain dehydrogenase/reductase enzymes in Bordetella O-antigen biosynthesis.
Journal of molecular biology 2007;374(3):749-63.
2007: Harmer Nicholas J; King Jerry D; Palmer Colin M; Preston Andrew; Maskell Duncan J; Blundell Tom L
Cloning, expression, purification and preliminary crystallographic analysis of the short-chain dehydrogenase enzymes WbmF, WbmG and WbmH from Bordetella bronchiseptica.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 8):711-5.
2007: Cheng Tammy Man-Kuang; Blundell Tom L; Fernandez-Recio Juan
pyDock: electrostatics and desolvation for effective scoring of rigid-body protein-protein docking.
Proteins 2007;68(2):503-15.
2007: Sanders Jane; Chirgadze Dimitri Y; Sanders Paul; Baker Stuart; Sullivan Andrew; Bhardwaja Anshu; Bolton Jane; Reeve Magnus; Nakatake Nobuhiro; Evans Michele; Richards Tonya; Powell Michael; Miguel Ricardo Núñez; Blundell Tom L; Furmaniak Jadwiga; Smith Bernard Rees
Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody.
Thyroid : official journal of the American Thyroid Association 2007;17(5):395-410.
2007: Smith Richard E; Lovell Simon C; Burke David F; Montalvao Rinaldo W; Blundell Tom L
Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities.
Bioinformatics (Oxford, England) 2007;23(9):1099-105.
2007: Kerbarh Olivier; Ciulli Alessio; Chirgadze Dimitri Y; Blundell Tom L; Abell Chris
Nucleophile selectivity of chorismate-utilizing enzymes.
Chembiochem : a European journal of chemical biology 2007;8(6):622-4.
2007: Ciulli Alessio; Chirgadze Dimitri Y; Smith Alison G; Blundell Tom L; Abell Chris
Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity.
The Journal of biological chemistry 2007;282(11):8487-97.
2007: Ciulli Alessio; Lobley Carina M C; Tuck Kellie L; Smith Alison G; Blundell Tom L; Abell Chris
pH-tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 2):171-8.
2007: Burke David F; Worth Catherine L; Priego Eva-Maria; Cheng Tammy; Smink Luc J; Todd John A; Blundell Tom L
Genome bioinformatic analysis of nonsynonymous SNPs.
BMC bioinformatics 2007;8():301.
2007: Gore Swanand P; Karmali Anjum M; Blundell Tom L
Rappertk: a versatile engine for discrete restraint-based conformational sampling of macromolecules.
BMC structural biology 2007;7():13.
2006: Bolanos-Garcia Victor Martin; Fernandez-Recio Juan; Allende Jorge E; Blundell Tom L
Identifying interaction motifs in CK2beta--a ubiquitous kinase regulatory subunit.
Trends in biochemical sciences 2006;31(12):654-61.
2006: Blundell Tom L; Fernández-Recio Juan
Cell biology: brief encounters bolster contacts.
Nature 2006;444(7117):279-80.
2006: Popovic Bojana; Tang Xiao; Chirgadze Dimitri Y; Huang Fanglu; Blundell Tom L; Spencer Jonathan B
Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis.
Proteins 2006;65(1):220-30.
2006: Furnham Nicholas; Doré Andrew S; Chirgadze Dimitri Y; de Bakker Paul I W; Depristo Mark A; Blundell Tom L
Knowledge-based real-space explorations for low-resolution structure determination.
Structure (London, England : 1993) 2006;14(8):1313-20.
2006: Ciulli Alessio; Williams Glyn; Smith Alison G; Blundell Tom L; Abell Chris
Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.
Journal of medicinal chemistry 2006;49(16):4992-5000.
2006: Hoskins Jemima; Lovell Simon; Blundell Tom L
An algorithm for predicting protein-protein interaction sites: Abnormally exposed amino acid residues and secondary structure elements.
Protein science : a publication of the Protein Society 2006;15(5):1017-29.
2006: Chelliah Vijayalakshmi; Blundell Tom L; Fernández-Recio Juan
Efficient restraints for protein-protein docking by comparison of observed amino acid substitution patterns with those predicted from local environment.
Journal of molecular biology 2006;357(5):1669-82.
2006: de Bakker Paul I W; Furnham Nicholas; Blundell Tom L; DePristo Mark A
Conformer generation under restraints.
Current opinion in structural biology 2006;16(2):160-5.
2006: Gherardi Ermanno; Sandin Sara; Petoukhov Maxim V; Finch John; Youles Mark E; Ofverstedt Lars-Göran; Miguel Ricardo N; Blundell Tom L; Vande Woude George F; Skoglund Ulf; Svergun Dmitri I
Structural basis of hepatocyte growth factor/scatter factor and MET signalling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4046-51.
2006: Blundell Tom L; Sibanda Bancinyane L; Montalvão Rinaldo Wander; Brewerton Suzanne; Chelliah Vijayalakshmi; Worth Catherine L; Harmer Nicholas J; Davies Owen; Burke David
Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1467):413-23.
2006: Furnham Nicholas; Blundell Tom L; DePristo Mark A; Terwilliger Thomas C
Is one solution good enough?
Nature structural & molecular biology 2006;13(3):184-5; discussion 185.
2006: Kerbarh Olivier; Chirgadze Dimitri Y; Blundell Tom L; Abell Chris
Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate.
Journal of molecular biology 2006;357(2):524-34.
2006: Doré Andrew S; Furnham Nicholas; Davies Owen R; Sibanda Bancinyane L; Chirgadze Dimitri Y; Jackson Stephen P; Pellegrini Luca; Blundell Tom L
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
DNA repair 2006;5(3):362-8.
2006: Harmer Nicholas J; Robinson Christopher J; Adam Lucy E; Ilag Leopold L; Robinson Carol V; Gallagher John T; Blundell Tom L
Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin.
The Biochemical journal 2006;393(Pt 3):741-8.
2005: Miguel Ricardo Núñez; Chen Shu; Nikfarjam Laleh; Kominami Shiro; Carpenter Byron; Dal Pra Chiara; Betterle Corrado; Zanchetta Renato; Nakamatsu Takashi; Powell Michael; Hewer Rachel; Blundell Tom L; Smith Bernard Rees; Furmaniak Jadwiga
Analysis of the interaction between human steroid 21-hydroxylase and various monoclonal antibodies using comparative structural modelling.
European journal of endocrinology / European Federation of Endocrine Societies 2005;153(6):949-61.
2005: Robinson Christopher J; Harmer Nicholas J; Goodger Sarah J; Blundell Tom L; Gallagher John T
Cooperative dimerization of fibroblast growth factor 1 (FGF1) upon a single heparin saccharide may drive the formation of 2:2:1 FGF1.FGFR2c.heparin ternary complexes.
The Journal of biological chemistry 2005;280(51):42274-82.
2005: Chelliah Vijayalakshmi; Blundell Tom; Mizuguchi Kenji
Functional restraints on the patterns of amino acid substitutions: application to sequence-structure homology recognition.
Proteins 2005;61(4):722-31.
2005: Carafoli Federico; Chirgadze Dimitri Y; Blundell Tom L; Gherardi Ermanno
Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein.
The FEBS journal 2005;272(22):5799-807.
2005: Ehebauer Matthias T; Chirgadze Dimitri Y; Hayward Penny; Martinez Arias Alfonso; Blundell Tom L
High-resolution crystal structure of the human Notch 1 ankyrin domain.
The Biochemical journal 2005;392(Pt 1):13-20.
2005: Montalvão Rinaldo W; Smith Richard E; Lovell Simon C; Blundell Tom L
CHORAL: a differential geometry approach to the prediction of the cores of protein structures.
Bioinformatics (Oxford, England) 2005;21(19):3719-25.
2005: Bolanos-Garcia V M; Beaufils S; Renault A; Grossmann J G; Brewerton S; Lee M; Venkitaraman A; Blundell T L
The conserved N-terminal region of the mitotic checkpoint protein BUBR1: a putative TPR motif of high surface activity.
Biophysical journal 2005;89(4):2640-9.
2005: Depristo Mark A; de Bakker Paul I W; Johnson Russell J K; Blundell Tom L
Crystallographic refinement by knowledge-based exploration of complex energy landscapes.
Structure (London, England : 1993) 2005;13(9):1311-9.
2005: Aurikko Jukka P; Ruotolo Brandon T; Grossmann J Günter; Moncrieffe Martin C; Stephens Elaine; Leppänen Veli-Matti; Robinson Carol V; Saarma Mart; Bradshaw Ralph A; Blundell Tom L
Characterization of symmetric complexes of nerve growth factor and the ectodomain of the pan-neurotrophin receptor, p75NTR.
The Journal of biological chemistry 2005;280(39):33453-60.
2005: Chelliah V; Blundell T L
Quantifying structural and functional restraints on amino acid substitutions in evolution of proteins.
Biochemistry. Biokhimii?a 2005;70(8):835-40.
2005: Coxon K M; Chakauya E; Ottenhof H H; Whitney H M; Blundell T L; Abell C; Smith A G
Pantothenate biosynthesis in higher plants.
Biochemical Society transactions 2005;33(Pt 4):743-6.
2005: Gore Swanand P; Burke David F; Blundell Tom L
PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes.
Bioinformatics (Oxford, England) 2005;21(15):3316-7.
2005: Miguel Ricardo Núñez; Sanders Jane; Blundell Tom L; Smith Bernard Rees; Furmaniak Jadwiga
Comparative modeling of the thyrotropin receptor.
Thyroid : official journal of the American Thyroid Association 2005;15(7):746-7.
2005: Sanders J; Allen F; Jeffreys J; Bolton J; Richards T; Depraetere H; Nakatake N; Evans M; Kiddie A; Premawardhana L D K E; Chirgadze D Y; Miguel R Núñez; Blundell T L; Furmaniak J; Smith B Rees
Characteristics of a monoclonal antibody to the thyrotropin receptor that acts as a powerful thyroid-stimulating autoantibody antagonist.
Thyroid : official journal of the American Thyroid Association 2005;15(7):672-82.
2005: Lobley Carina M C; Ciulli Alessio; Whitney Heather M; Williams Glyn; Smith Alison G; Abell Chris; Blundell Tom L
The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.
Biochemistry 2005;44(25):8930-9.
2005: Blundell Tom L
New strategies for structure-guided design of AIDS antivirals.
Progress in biophysics and molecular biology 2005;88(2):191-2.
2005: Messenger Nigel J; Kabitschke Christin; Andrews Robert; Grimmer Donna; Núñez Miguel Ricardo; Blundell Tom L; Smith James C; Wardle Fiona C
Functional specificity of the Xenopus T-domain protein Brachyury is conferred by its ability to interact with Smad1.
Developmental cell 2005;8(4):599-610.
2005: Cubellis M V; Caillez F; Blundell T L; Lovell S C
Properties of polyproline II, a secondary structure element implicated in protein-protein interactions.
Proteins 2005;58(4):880-92.
2005: Harmer Nicholas J; Sivak Jeremy M; Amaya Enrique; Blundell Tom L
1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
FEBS letters 2005;579(5):1161-6.
2004: Núñez Miguel Ricardo; Sanders Jane; Jeffreys Jennifer; Depraetere Hilde; Evans Michele; Richards Tonya; Blundell Tom L; Rees Smith Bernard; Furmaniak Jadwiga
Analysis of the thyrotropin receptor-thyrotropin interaction by comparative modeling.
Thyroid : official journal of the American Thyroid Association 2004;14(12):991-1011.
2004: Bertrand Loic; Sayed Muhammed F R; Pei Xue-Yuan; Parisini Emilio; Dhanaraj Venugopal; Bolanos-Garcia Victor M; Allende Jorge E; Blundell Tom L
Structure of the regulatory subunit of CK2 in the presence of a p21WAF1 peptide demonstrates flexibility of the acidic loop.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 10):1698-704.
2004: Chelliah Vijayalakshmi; Chen Lan; Blundell Tom L; Lovell Simon C
Distinguishing structural and functional restraints in evolution in order to identify interaction sites.
Journal of molecular biology 2004;342(5):1487-504.
2004: Blundell Tom L; Patel S
High-throughput X-ray crystallography for drug discovery.
Current opinion in pharmacology 2004;4(5):490-6.
2004: Sanders J; Jeffreys J; Depraetere H; Evans M; Richards T; Kiddie A; Brereton K; Premawardhana L D K E; Chirgadze D Y; Núñez Miguel R; Blundell T L; Furmaniak J; Rees Smith B
Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function.
Thyroid : official journal of the American Thyroid Association 2004;14(8):560-70.
2004: Harmer Nicholas J; Ilag Leopold L; Mulloy Barbara; Pellegrini Luca; Robinson Carol V; Blundell Tom L
Towards a resolution of the stoichiometry of the fibroblast growth factor (FGF)-FGF receptor-heparin complex.
Journal of molecular biology 2004;339(4):821-34.
2004: DePristo Mark A; de Bakker Paul I W; Blundell Tom L
Heterogeneity and inaccuracy in protein structures solved by X-ray crystallography.
Structure (London, England : 1993) 2004;12(5):831-8.
2004: Badasso Mohammed O; Dhanaraj V; Wood S P; Cooper J B; Blundell T L
Crystallization and X-ray analysis of the Y75N mutant of Mucor pusillus pepsin complexed with inhibitor.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 4):770-2.
2004: Brewerton Suzanne C; Doré Andrew S; Drake Adam C B; Leuther Kerstin K; Blundell Tom L
Structural analysis of DNA-PKcs: modelling of the repeat units and insights into the detailed molecular architecture.
Journal of structural biology 2004;145(3):295-306.
2004: Harmer Nicholas J; Pellegrini Luca; Chirgadze Dima; Fernandez-Recio Juan; Blundell Tom L
The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.
Biochemistry 2004;43(3):629-40.
2004: Doré Andrew S; Drake Adam C B; Brewerton Suzanne C; Blundell Tom L
Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining.
DNA repair 2004;3(1):33-41.
2004: Ottenhof Harald H; Ashurst Jennifer L; Whitney Heather M; Saldanha S Adrian; Schmitzberger Florian; Gweon Hyun Soon; Blundell Tom L; Abell Chris; Smith Alison G
Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants.
The Plant journal : for cell and molecular biology 2004;37(1):61-72.
2003: Shetty Reshma P; De Bakker Paul I W; DePristo Mark A; Blundell Tom L
Advantages of fine-grained side chain conformer libraries.
Protein engineering 2003;16(12):963-9.
2003: Schmitzberger Florian; Kilkenny Mairi L; Lobley Carina M C; Webb Michael E; Vinkovic Mladen; Matak-Vinkovic Dijana; Witty Michael; Chirgadze Dimitri Y; Smith Alison G; Abell Chris; Blundell Tom L
Structural constraints on protein self-processing in L-aspartate-alpha-decarboxylase.
The EMBO journal 2003;22(23):6193-204.
2003: Owen Darerca; Lowe Peter N; Nietlispach Daniel; Brosnan C Elaine; Chirgadze Dimitri Y; Parker Peter J; Blundell Tom L; Mott Helen R
Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).
The Journal of biological chemistry 2003;278(50):50578-87.
2003: Yu David S; Sonoda Eiichiro; Takeda Shunichi; Huang Christopher L H; Pellegrini Luca; Blundell Tom L; Venkitaraman Ashok R
Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2.
Molecular cell 2003;12(4):1029-41.
2003: Gherardi Ermanno; Youles Mark E; Miguel Ricardo N; Blundell Tom L; Iamele Luisa; Gough Julian; Bandyopadhyay Abhishek; Hartmann Guido; Butler P Jonathan G
Functional map and domain structure of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12039-44.
2003: Lo Thomas; Pellegrini Luca; Venkitaraman Ashok R; Blundell Tom L
Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer.
DNA repair 2003;2(9):1015-28.
2003: Shin David S; Pellegrini Luca; Daniels Douglas S; Yelent Biana; Craig Lisa; Bates Debbie; Yu David S; Shivji Mahmud K; Hitomi Chiharu; Arvai Andrew S; Volkmann Niels; Tsuruta Hiro; Blundell Tom L; Venkitaraman Ashok R; Tainer John A
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
The EMBO journal 2003;22(17):4566-76.
2003: DePristo Mark A; De Bakker Paul I W; Shetty Reshma P; Blundell Tom L
Discrete restraint-based protein modeling and the Calpha-trace problem.
Protein science : a publication of the Protein Society 2003;12(9):2032-46.
2003: von Delft Frank; Inoue Tsuyoshi; Saldanha S Adrian; Ottenhof Harald H; Schmitzberger Florian; Birch Louise M; Dhanaraj Venugopal; Witty Michael; Smith Alison G; Blundell Tom L; Abell Chris
Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.
Structure (London, England : 1993) 2003;11(8):985-96.
2003: Miguel Ricardo Nunez; Sanders Jane; Jeffreys Jennifer; Depraetere Hilde; Blundell Tom; Furmaniak Jadwiga; Rees Smith Bernard
Thyrotropin receptor cleavage domain and tissue inhibitor of metalloproteinase-2.
Thyroid : official journal of the American Thyroid Association 2003;13(7):665-6.
2003: Schmitzberger Florian; Smith Alison G; Abell Chris; Blundell Tom L
Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (betaalpha)8 phosphoenolpyruvate/pyruvate superfamily.
Journal of bacteriology 2003;185(14):4163-71.
2003: Lobley C M C; Schmitzberger F; Kilkenny M L; Whitney H; Ottenhof H H; Chakauya E; Webb M E; Birch L M; Tuck K L; Abell C; Smith A G; Blundell T L
Structural insights into the evolution of the pantothenate-biosynthesis pathway.
Biochemical Society transactions 2003;31(Pt 3):563-71.
2003: Evans Paul C; Smith Trevor S; Lai Meng-Jiun; Williams Mark G; Burke David F; Heyninck Karen; Kreike Marja M; Beyaert Rudi; Blundell Tom L; Kilshaw Peter J
A novel type of deubiquitinating enzyme.
The Journal of biological chemistry 2003;278(25):23180-6.
2003: DePristo Mark A; de Bakker Paul I W; Lovell Simon C; Blundell Tom L
Ab initio construction of polypeptide fragments: efficient generation of accurate, representative ensembles.
Proteins 2003;51(1):41-55.
2003: de Bakker Paul I W; DePristo Mark A; Burke David F; Blundell Tom L
Ab initio construction of polypeptide fragments: Accuracy of loop decoy discrimination by an all-atom statistical potential and the AMBER force field with the Generalized Born solvation model.
Proteins 2003;51(1):21-40.
2003: Harmer Nicholas J; Chirgadze Dima; Hyun Kim Kyung; Pellegrini Luca; Blundell Tom L
The structural biology of growth factor receptor activation.
Biophysical chemistry 2003;100(1-3):545-53.
2002: Pellegrini Luca; Yu David S; Lo Thomas; Anand Shubha; Lee MiYoung; Blundell Tom L; Venkitaraman Ashok R
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
Nature 2002;420(6913):287-93.
2002: Patel S; Martínez-Ripoll M; Blundell Tom L; Albert A
Structural enzymology of Li(+)-sensitive/Mg(2+)-dependent phosphatases.
Journal of molecular biology 2002;320(5):1087-94.
2002: Watanabe Keiichi; Chirgadze Dimitri Y; Lietha Daniel; de Jonge Hugo; Blundell Tom L; Gherardi Ermanno
A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping.
Journal of molecular biology 2002;319(2):283-8.
2002: Blundell Tom L; Jhoti Harren; Abell Chris
High-throughput crystallography for lead discovery in drug design.
Nature reviews. Drug discovery 2002;1(1):45-54.
2002: Patel S; Yenush L; Rodríguez P L; Serrano R; Blundell T L
Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.
Journal of molecular biology 2002;315(4):677-85.
2001: Matak-Vinkovic D; Vinkovic M; Saldanha S A; Ashurst J L; von Delft F; Inoue T; Miguel R N; Smith A G; Blundell T L; Abell C
Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism.
Biochemistry 2001;40(48):14493-500.
2001: Sibanda B L; Critchlow S E; Begun J; Pei X Y; Jackson S P; Blundell T L; Pellegrini L
Crystal structure of an Xrcc4-DNA ligase IV complex.
Nature structural biology 2001;8(12):1015-9.
2001: Lietha D; Chirgadze D Y; Mulloy B; Blundell T L; Gherardi E
Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.
The EMBO journal 2001;20(20):5543-55.
2001: de Bakker P I; Bateman A; Burke D F; Miguel R N; Mizuguchi K; Shi J; Shirai H; Blundell T L
HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families.
Bioinformatics (Oxford, England) 2001;17(8):748-9.
2001: Shirai H; Blundell T L; Mizuguchi K
A novel superfamily of enzymes that catalyze the modification of guanidino groups.
Trends in biochemical sciences 2001;26(8):465-8.
2001: Nagendra H G; Harrington A E; Harmer N J; Pellegrini L; Blundell T L; Burke D F
Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution.
FEBS letters 2001;501(1):51-8.
2001: Shi J; Blundell T L; Mizuguchi K
FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties.
Journal of molecular biology 2001;310(1):243-57.
2001: Deane C M; Kaas Q; Blundell T L
SCORE: predicting the core of protein models.
Bioinformatics (Oxford, England) 2001;17(6):541-50.
2001: von Delft F; Lewendon A; Dhanaraj V; Blundell T L; Abell C; Smith A G
The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily.
Structure (London, England : 1993) 2001;9(5):439-50.
2001: Deane C M; Blundell T L
CODA: a combined algorithm for predicting the structurally variable regions of protein models.
Protein science : a publication of the Protein Society 2001;10(3):599-612.
2001: Williams M G; Shirai H; Shi J; Nagendra H G; Mueller J; Mizuguchi K; Miguel R N; Lovell S C; Innis C A; Deane C M; Chen L; Campillo N; Burke D F; Blundell T L; de Bakker P I
Sequence-structure homology recognition by iterative alignment refinement and comparative modeling.
Proteins 2001;Suppl 5():92-7.
2000: Innis C A; Shi J; Blundell T L
Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis.
Protein engineering 2000;13(12):839-47.
2000: Mizuguchi K; Blundell T
Analysis of conservation and substitutions of secondary structure elements within protein superfamilies.
Bioinformatics (Oxford, England) 2000;16(12):1111-9.
2000: Pellegrini L; Burke D F; von Delft F; Mulloy B; Blundell T L
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin.
Nature 2000;407(6807):1029-34.
2000: Blundell T L; Burke D F; Chirgadze D; Dhanaraj V; Hyvönen M; Innis C A; Parisini E; Pellegrini L; Sayed M; Sibanda B L
Protein-protein interactions in receptor activation and intracellular signalling.
Biological chemistry 2000;381(9-10):955-9.
2000: Badasso M O; Read J A; Dhanaraj V; Cooper J B; Wood S P; Blundell T L; Dreyer T; Winther J
Purification, co-crystallization and preliminary X--ray analysis of the natural aspartic proteinase inhibitor IA3 complexed with saccharopepsin from Saccharomyces cerevisiae.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 7):915-7.
2000: Deane C M; Blundell T L
A novel exhaustive search algorithm for predicting the conformation of polypeptide segments in proteins.
Proteins 2000;40(1):135-44.
2000: Burke D F; Deane C M; Blundell T L
Browsing the SLoop database of structurally classified loops connecting elements of protein secondary structure.
Bioinformatics (Oxford, England) 2000;16(6):513-9.
2000: Blundell T L; Mizuguchi K
Structural genomics: an overview.
Progress in biophysics and molecular biology 2000;73(5):289-95.
1999: Nagarajaram H A; Reddy B V; Blundell T L
Analysis and prediction of inter-strand packing distances between beta-sheets of globular proteins.
Protein engineering 1999;12(12):1055-62.
1999: Deane C M; Allen F H; Taylor R; Blundell T L
Carbonyl-carbonyl interactions stabilize the partially allowed Ramachandran conformations of asparagine and aspartic acid.
Protein engineering 1999;12(12):1025-8.
1999: Mizuguchi K; Dhanaraj V; Blundell T L; Murzin A G
N-ethylmaleimide-sensitive fusion protein (NSF) and CDC48 confirmed as members of the double-psi beta-barrel aspartate decarboxylase/formate dehydrogenase family.
Structure (London, England : 1993) 1999;7(9):R215-6.
1999: Marino-Buslje C; Martin-Martinez M; Mizuguchi K; Siddle K; Blundell T L
The insulin receptor: from protein sequence to structure.
Biochemical Society transactions 1999;27(4):715-26.
1999: Pavlovsky A G; Williams M G; Ye Q Z; Ortwine D F; Purchase C F; White A D; Dhanaraj V; Roth B D; Johnson L L; Hupe D; Humblet C; Blundell T L
X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.
Protein science : a publication of the Protein Society 1999;8(7):1455-62.
1999: Reddy B V; Nagarajaram H A; Blundell T L
Analysis of interactive packing of secondary structural elements in alpha/beta units in proteins.
Protein science : a publication of the Protein Society 1999;8(3):573-86.
1999: Castillo R M; Mizuguchi K; Dhanaraj V; Albert A; Blundell T L; Murzin A G
A six-stranded double-psi beta barrel is shared by several protein superfamilies.
Structure (London, England : 1993) 1999;7(2):227-36.
1999: Srinivasan N; Antonelli M; Jacob G; Korn I; Romero F; Jedlicki A; Dhanaraj V; Sayed M F; Blundell T L; Allende C C; Allende J E
Structural interpretation of site-directed mutagenesis and specificity of the catalytic subunit of protein kinase CK2 using comparative modelling.
Protein engineering 1999;12(2):119-27.
1999: Korn I; Gutkind S; Srinivasan N; Blundell T L; Allende C C; Allende J E
Interactions of protein kinase CK2 subunits.
Molecular and cellular biochemistry 1999;191(1-2):75-83.
1999: Chirgadze D Y; Hepple J P; Zhou H; Byrd R A; Blundell T L; Gherardi E
Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding.
Nature structural biology 1999;6(1):72-9.
1999: Burke D F; Deane C M; Nagarajaram H A; Campillo N; Martin-Martinez M; Mendes J; Molina F; Perry J; Reddy B V; Soares C M; Steward R E; Williams M; Carrondo M A; Blundell T L; Mizuguchi K
An iterative structure-assisted approach to sequence alignment and comparative modeling.
Proteins 1999;Suppl 3():55-60.
1998: Marino-Buslje C; Mizuguchi K; Siddle K; Blundell T L
A third fibronectin type III domain in the extracellular region of the insulin receptor family.
FEBS letters 1998;441(2):331-6.
1998: Sowdhamini R; Burke D F; Deane C; Huang J F; Mizuguchi K; Nagarajaram H A; Overington J P; Srinivasan N; Steward R E; Blundell T L
Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 1):1168-77.
1998: Rodionov M A; Blundell T L
Sequence and structure conservation in a protein core.
Proteins 1998;33(3):358-66.
1998: Mizuguchi K; Deane C M; Blundell T L; Overington J P
HOMSTRAD: a database of protein structure alignments for homologous families.
Protein science : a publication of the Protein Society 1998;7(11):2469-71.
1998: Groves M R; Dhanaraj V; Badasso M; Nugent P; Pitts J E; Hoover D J; Blundell T L
A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
Protein engineering 1998;11(10):833-40.
1998: Sowdhamini R; Burke D F; Huang J F; Mizuguchi K; Nagarajaram H A; Srinivasan N; Steward R E; Blundell T L
CAMPASS: a database of structurally aligned protein superfamilies.
Structure (London, England : 1993) 1998;6(9):1087-94.
1998: Brotherton D H; Dhanaraj V; Wick S; Brizuela L; Domaille P J; Volyanik E; Xu X; Parisini E; Smith B O; Archer S J; Serrano M; Brenner S L; Blundell T L; Laue E D
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.
Nature 1998;395(6699):244-50.
1998: Pellegrini L; Commander P; Mulloy B; Martin-Martinez M; Blundell T L; Burke D F
The role of heparin in the complex formation between fibroblast growth factor 2 and its high affinity receptor: comparative modelling and biochemical studies.
Biochemical Society transactions 1998;26(3):545-9.
1998: Loew A; Ho Y K; Blundell T; Bax B
Phosducin induces a structural change in transducin beta gamma.
Structure (London, England : 1993) 1998;6(8):1007-19.
1998: Mizuguchi K; Parker J S; Blundell T L; Gay N J
Getting knotted: a model for the structure and activation of Spätzle.
Trends in biochemical sciences 1998;23(7):239-42.
1998: Blundell T L
Leaving the structured world of Oxford.
Nature structural biology 1998;5(7):533.
1998: Chirgadze D Y; Hepple J; Byrd R A; Sowdhamini R; Blundell T L; Gherardi E
Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation.
FEBS letters 1998;430(1-2):126-9.
1998: Snook C F; Woolley G A; Oliva G; Pattabhi V; Wood S F; Blundell T L; Wallace B A
The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide.
Structure (London, England : 1993) 1998;6(6):783-92.
1998: Albert A; Dhanaraj V; Genschel U; Khan G; Ramjee M K; Pulido R; Sibanda B L; von Delft F; Witty M; Blundell T L; Smith A G; Abell C
Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.
Nature structural biology 1998;5(4):289-93.
1998: Burke D; Wilkes D; Blundell T L; Malcolm S
Fibroblast growth factor receptors: lessons from the genes.
Trends in biochemical sciences 1998;23(2):59-62.
1998: Mizuguchi K; Deane C M; Blundell T L; Johnson M S; Overington J P
JOY: protein sequence-structure representation and analysis.
Bioinformatics (Oxford, England) 1998;14(7):617-23.
1998: Albert A; Blundell T L; Dhanaraj V; Donate L E; Groves M; Guruprasad K; Nugent P G; Orprayoon P; Pitts J E; Rufino S; Srinivasan N; Williams M; Wilsher J
Protein engineering aspartic proteinases. Site-directed mutagenesis, biochemical characterisation, and X-ray analysis of chymosins with substituted single amino acid substitutions and loop replacements.
Advances in experimental medicine and biology 1998;436():169-77.
1998: Blundell T L; Guruprasad K; Albert A; Williams M; Sibanda B L; Dhanaraj V
The aspartic proteinases. An historical overview.
Advances in experimental medicine and biology 1998;436():1-13.
1997: Bax B; Blundell T L; Murray-Rust J; McDonald N Q
Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins.
Structure (London, England : 1993) 1997;5(10):1275-85.
1997: Williams M G; Wilsher J; Nugent P; Mills A; Dhanaraj V; Fabry M; Sedlácek J; Uusitalo J M; Penttila M E; Pitts J E; Blundell T L
Mutagenesis, biochemical characterization and X-ray structural analysis of point mutants of bovine chymosin.
Protein engineering 1997;10(9):991-7.
1997: Aguilar C F; Cronin N B; Badasso M; Dreyer T; Newman M P; Cooper J B; Hoover D J; Wood S P; Johnson M S; Blundell T L
The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae.
Journal of molecular biology 1997;267(4):899-915.
1997: Rufino S D; Donate L E; Canard L H; Blundell T L
Predicting the conformational class of short and medium size loops connecting regular secondary structures: application to comparative modelling.
Journal of molecular biology 1997;267(2):352-67.
1997: Topham C M; Srinivasan N; Blundell T L
Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables.
Protein engineering 1997;10(1):7-21.
1997: Gherardi E; Hartmann G; Hepple J; Chirgadze D; Srinivasan N; Blundell T
Domain structure of hepatocyte growth factor/scatter factor (HGF/SF).
Ciba Foundation symposium 1997;212():84-93; discussion 93-104.
1996: Donate L E; Rufino S D; Canard L H; Blundell T L
Conformational analysis and clustering of short and medium size loops connecting regular secondary structures: a database for modeling and prediction.
Protein science : a publication of the Protein Society 1996;5(12):2600-16.
1996: Blundell T L
Structure-based drug design.
Nature 1996;384(6604 Suppl):23-6.
1996: Nugent P G; Albert A; Orprayoon P; Wilsher J; Pitts J E; Blundell T L; Dhanaraj V
Protein engineering loops in aspartic proteinases: site-directed mutagenesis, biochemical characterization and X-ray analysis of chymosin with a replaced loop from rhizopuspepsin.
Protein engineering 1996;9(10):885-93.
1996: Guruprasad K; Blundell T L; Xie S; Green J; Szafranska B; Nagel R J; McDowell K; Baker C B; Roberts R M
Comparative modelling and analysis of amino acid substitutions suggests that the family of pregnancy-associated glycoproteins includes both active and inactive aspartic proteinases.
Protein engineering 1996;9(10):849-56.
1996: Srinivasan N; Bax B; Blundell T L; Parker P J
Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses.
Proteins 1996;26(2):217-35.
1996: Zhu Z Y; Blundell T L
The use of amino acid patterns of classified helices and strands in secondary structure prediction.
Journal of molecular biology 1996;260(2):261-76.
1996: Louie G V; Brownlie P D; Lambert R; Cooper J B; Blundell T L; Wood S P; Malashkevich V N; Hädener A; Warren M J; Shoolingin-Jordan P M
The three-dimensional structure of Escherichia coli porphobilinogen deaminase at 1.76-A resolution.
Proteins 1996;25(1):48-78.
1996: Dhanaraj V; Ye Q Z; Johnson L L; Hupe D J; Ortwine D F; Dunbar J B; Rubin J R; Pavlovsky A; Humblet C; Blundell T L
Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.
Drug design and discovery 1996;13(3-4):3-14.
1996: Dhanaraj V; Ye Q Z; Johnson L L; Hupe D J; Ortwine D F; Dunbar J B; Rubin J R; Pavlovsky A; Humblet C; Blundell T L
X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.
Structure (London, England : 1993) 1996;4(4):375-86.
1996: Srinivasan V; Waterfield M D; Blundell T L
Comparative analysis of the regions binding beta gamma-subunits in Galpha and PH domains.
Biochemical and biophysical research communications 1996;220(3):697-702.
1996: Rufino S D; Donate L E; Canard L; Blundell T L
Analysis, clustering and prediction of the conformation of short and medium size loops connecting regular secondary structures.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 1996;():570-89.
1996: Sowdhamini R; Rufino S D; Blundell T L
A database of globular protein structural domains: clustering of representative family members into similar folds.
Folding & design 1996;1(3):209-20.
1995: Guruprasad L; Dhanaraj V; Timm D; Blundell T L; Gout I; Waterfield M D
The crystal structure of the N-terminal SH3 domain of Grb2.
Journal of molecular biology 1995;248(4):856-66.
1995: Sowdhamini R; Blundell T L
An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins.
Protein science : a publication of the Protein Society 1995;4(3):506-20.
1995: McDonald N Q; Murray-Rust J; Blundell T L
The first structure of a receptor tyrosine kinase domain: a further step in understanding the molecular basis of insulin action.
Structure (London, England : 1993) 1995;3(1):1-6.
1995: Dhanaraj R R; Pitts J E; Nugent P; Orprayoon P; Cooper J B; Blundell T L; Uusitalo J; Penttilä M
Protein engineering of surface loops: preliminary X-ray analysis of the CHY155-165RHI mutant.
Advances in experimental medicine and biology 1995;362():95-9.
1995: Kervinen J; Törmäkangas K; Runeberg-Roos P; Guruprasad K; Blundell T; Teeri T H
Structure and possible function of aspartic proteinases in barley and other plants.
Advances in experimental medicine and biology 1995;362():241-54.
1995: Aguilar C F; Dhanaraj V; Guruprasad K; Dealwis C; Badasso M; Cooper J B; Wood S P; Blundell T L
Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D.
Advances in experimental medicine and biology 1995;362():155-66.
1994: Narasimhan L; Singh J; Humblet C; Guruprasad K; Blundell T
Snail and spider toxins share a similar tertiary structure and 'cystine motif'.
Nature structural biology 1994;1(12):850-2.
1994: Donate L E; Gherardi E; Srinivasan N; Sowdhamini R; Aparicio S; Blundell T L
Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP).
Protein science : a publication of the Protein Society 1994;3(12):2378-94.
1994: Srinivasan N; White H E; Emsley J; Wood S P; Pepys M B; Blundell T L
Comparative analyses of pentraxins: implications for protomer assembly and ligand binding.
Structure (London, England : 1993) 1994;2(11):1017-27.
1994: Bradshaw R A; Murray-Rust J; Ibáñez C F; McDonald N Q; Lapatto R; Blundell T L
Nerve growth factor: structure/function relationships.
Protein science : a publication of the Protein Society 1994;3(11):1901-13.
1994: Timm D; Salim K; Gout I; Guruprasad L; Waterfield M; Blundell T
Crystal structure of the pleckstrin homology domain from dynamin.
Nature structural biology 1994;1(11):782-8.
1994: Brownlie P D; Lambert R; Louie G V; Jordan P M; Blundell T L; Warren M J; Cooper J B; Wood S P
The three-dimensional structures of mutants of porphobilinogen deaminase: toward an understanding of the structural basis of acute intermittent porphyria.
Protein science : a publication of the Protein Society 1994;3(10):1644-50.
1994: Guruprasad K; Törmäkangas K; Kervinen J; Blundell T L
Comparative modelling of barley-grain aspartic proteinase: a structural rationale for observed hydrolytic specificity.
FEBS letters 1994;352(2):131-6.
1994: May A C; Blundell T L
Automated comparative modelling of protein structures.
Current opinion in biotechnology 1994;5(4):355-60.
1994: May A C; Johnson M S; Rufino S D; Wako H; Zhu Z Y; Sowdhamini R; Srinivasan N; Rodionov M A; Blundell T L
The recognition of protein structure and function from sequence: adding value to genome data.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;344(1310):373-81.
1994: Wako H; Blundell T L
Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. II. Secondary structures.
Journal of molecular biology 1994;238(5):693-708.
1994: Wako H; Blundell T L
Use of amino acid environment-dependent substitution tables and conformational propensities in structure prediction from aligned sequences of homologous proteins. I. Solvent accessibility classes.
Journal of molecular biology 1994;238(5):682-92.
1994: Donnelly D; Overington J P; Blundell T L
The prediction and orientation of alpha-helices from sequence alignments: the combined use of environment-dependent substitution tables, Fourier transform methods and helix capping rules.
Protein engineering 1994;7(5):645-53.
1994: Dealwis C G; Frazao C; Badasso M; Cooper J B; Tickle I J; Driessen H; Blundell T L; Murakami K; Miyazaki H; Sueiras-Diaz J
X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
Journal of molecular biology 1994;236(1):342-60.
1994: Rufino S D; Blundell T L
Structure-based identification and clustering of protein families and superfamilies.
Journal of computer-aided molecular design 1994;8(1):5-27.
1994: Emsley J; White H E; O'Hara B P; Oliva G; Srinivasan N; Tickle I J; Blundell T L; Pepys M B; Wood S P
Structure of pentameric human serum amyloid P component.
Nature 1994;367(6461):338-45.
1994: Johnson M S; Srinivasan N; Sowdhamini R; Blundell T L
Knowledge-based protein modeling.
Critical reviews in biochemistry and molecular biology 1994;29(1):1-68.
1994: Lambert R; Brownlie P D; Woodcock S C; Louie G V; Cooper J C; Warren M J; Jordan P M; Blundell T L; Wood S P
Structural studies on porphobilinogen deaminase.
Ciba Foundation symposium 1994;180():97-104; discussion 105-10.
1993: Sali A; Blundell T L
Comparative protein modelling by satisfaction of spatial restraints.
Journal of molecular biology 1993;234(3):779-815.
1993: Reddy B V; Blundell T L
Packing of secondary structural elements in proteins. Analysis and prediction of inter-helix distances.
Journal of molecular biology 1993;233(3):464-79.
1993: Murray-Rust J; McDonald N Q; Blundell T L; Hosang M; Oefner C; Winkler F; Bradshaw R A
Topological similarities in TGF-beta 2, PDGF-BB and NGF define a superfamily of polypeptide growth factors.
Structure (London, England : 1993) 1993;1(2):153-9.
1993: Overington J P; Zhu Z Y; Sali A; Johnson M S; Sowdhamini R; Louie G V; Blundell T L
Molecular recognition in protein families: a database of aligned three-dimensional structures of related proteins.
Biochemical Society transactions 1993;21 ( Pt 3)(3):597-604.
1993: Srinivasan N; Blundell T L
An evaluation of the performance of an automated procedure for comparative modelling of protein tertiary structure.
Protein engineering 1993;6(5):501-12.
1993: Badasso M; Wood S P; Aguilar C; Cooper J B; Blundell T L; Dreyer T
Crystallization and preliminary crystallographic characterization of aspartic proteinase-A from baker's yeast and its complexes with inhibitors.
Journal of molecular biology 1993;232(2):701-3.
1993: Johnson M S; Overington J P; Blundell T L
Alignment and searching for common protein folds using a data bank of structural templates.
Journal of molecular biology 1993;231(3):735-52.
1993: Blundell T L; Johnson M S
Catching a common fold.
Protein science : a publication of the Protein Society 1993;2(6):877-83.
1993: Najmudin S; Nalini V; Driessen H P; Slingsby C; Blundell T L; Moss D S; Lindley P F
Structure of the bovine eye lens protein gammaB(gammaII)-crystallin at 1.47 A.
Acta crystallographica. Section D, Biological crystallography 1993;49(Pt 2):223-33.
1993: Newman M; Watson F; Roychowdhury P; Jones H; Badasso M; Cleasby A; Wood S P; Tickle I J; Blundell T L
X-ray analyses of aspartic proteinases. V. Structure and refinement at 2.0 A resolution of the aspartic proteinase from Mucor pusillus.
Journal of molecular biology 1993;230(1):260-83.
1993: Aguilar C F; Newman M P; Sanz Aparicio J; Cooper J B; Tickle I J; Blundell T L
The use of protein homologues in the rotation function.
Acta crystallographica. Section A, Foundations of crystallography 1993;49 ( Pt 2)():306-15.
1993: Bradshaw R A; Blundell T L; Lapatto R; McDonald N Q; Murray-Rust J
Nerve growth factor revisited.
Trends in biochemical sciences 1993;18(2):48-52.
1993: Scarborough P E; Guruprasad K; Topham C; Richo G R; Conner G E; Blundell T L; Dunn B M
Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling.
Protein science : a publication of the Protein Society 1993;2(2):264-76.
1993: Donnelly D; Overington J P; Ruffle S V; Nugent J H; Blundell T L
Modeling alpha-helical transmembrane domains: the calculation and use of substitution tables for lipid-facing residues.
Protein science : a publication of the Protein Society 1993;2(1):55-70.
1993: Bailey D; Cooper J B; Veerapandian B; Blundell T L; Atrash B; Jones D M; Szelke M
X-ray-crystallographic studies of complexes of pepstatin A and a statine-containing human renin inhibitor with endothiapepsin.
The Biochemical journal 1993;289 ( Pt 2)():363-71.
1993: Topham C M; McLeod A; Eisenmenger F; Overington J P; Johnson M S; Blundell T L
Fragment ranking in modelling of protein structure. Conformationally constrained environmental amino acid substitution tables.
Journal of molecular biology 1993;229(1):194-220.
1992: Cooper J; Quail W; Frazao C; Foundling S I; Blundell T L; Humblet C; Lunney E A; Lowther W T; Dunn B M
X-ray crystallographic analysis of inhibition of endothiapepsin by cyclohexyl renin inhibitors.
Biochemistry 1992;31(35):8142-50.
1992: Louie G V; Brownlie P D; Lambert R; Cooper J B; Blundell T L; Wood S P; Warren M J; Woodcock S C; Jordan P M
Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site.
Nature 1992;359(6390):33-9.
1992: Murray-Rust J; McLeod A N; Blundell T L; Wood S P
Structure and evolution of insulins: implications for receptor binding.
BioEssays : news and reviews in molecular, cellular and developmental biology 1992;14(5):325-31.
1992: Ibáñez C F; Ebendal T; Barbany G; Murray-Rust J; Blundell T L; Persson H
Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product.
Cell 1992;69(2):329-41.
1992: Jordan P M; Warren M J; Mgbeje B I; Wood S P; Cooper J B; Louie G; Brownlie P; Lambert R; Blundell T L
Crystallization and preliminary X-ray investigation of Escherichia coli porphobilinogen deaminase.
Journal of molecular biology 1992;224(1):269-71.
1992: Veerapandian B; Cooper J B; Sali A; Blundell T L; Rosati R L; Dominy B W; Damon D B; Hoover D J
Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases.
Protein science : a publication of the Protein Society 1992;1(3):322-8.
1992: Sali A; Veerapandian B; Cooper J B; Moss D S; Hofmann T; Blundell T L
Domain flexibility in aspartic proteinases.
Proteins 1992;12(2):158-70.
1992: Overington J; Donnelly D; Johnson M S; Sali A; Blundell T L
Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds.
Protein science : a publication of the Protein Society 1992;1(2):216-26.
1992: Badasso M; Frazao C; Sibanda B L; Dhanaraj V; DeAlwis C; Cooper J B; Wood S P; Blundell T L; Murakami K; Miyazaki H
Crystallization and preliminary X-ray analysis of complexes of peptide inhibitors with human recombinant and mouse submandibular renins.
Journal of molecular biology 1992;223(2):447-53.
1992: Zhu Z Y; Sali A; Blundell T L
A variable gap penalty function and feature weights for protein 3-D structure comparisons.
Protein engineering 1992;5(1):43-51.
1992: Pitts J E; Dhanaraj V; Dealwis C G; Mantafounis D; Nugent P; Orprayoon P; Cooper J B; Newman M; Blundell T L
Multidisciplinary cycles for protein engineering: site-directed mutagenesis and X-ray structural studies of aspartic proteinases.
Scandinavian journal of clinical and laboratory investigation. Supplementum 1992;210():39-50.
1991: McDonald N Q; Lapatto R; Murray-Rust J; Gunning J; Wlodawer A; Blundell T L
New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor.
Nature 1991;354(6352):411-4.
1991: Lapatto R; Nalini V; Bax B; Driessen H; Lindley P F; Blundell T L; Slingsby C
High resolution structure of an oligomeric eye lens beta-crystallin. Loops, arches, linkers and interfaces in beta B2 dimer compared to a monomeric gamma-crystallin.
Journal of molecular biology 1991;222(4):1067-83.
1991: Newman M; Safro M; Frazao C; Khan G; Zdanov A; Tickle I J; Blundell T L; Andreeva N
X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin.
Journal of molecular biology 1991;221(4):1295-309.
1991: Orprayoon P; Pitts J E; Nugent P; Mantafounis D; Lawler S E; Blundell T L; Uusitalo J; Penttilä M
Protein engineering of the surface loops of chymosin.
Biochemical Society transactions 1991;19(3):265S.
1991: McDonald N Q; Blundell T L
Crystallization and characterization of the high molecular weight form of nerve growth factor (7 S NGF).
Journal of molecular biology 1991;219(4):595-601.
1991: Blundell T L
Comparative analysis of protein three-dimensional structures and an approach to the inverse folding problem.
Ciba Foundation symposium 1991;161():28-36; discussion 37-51.
1991: Blundell T L; Cooper J B; Sali A; Zhu Z Y
Comparisons of the sequences, 3-D structures and mechanisms of pepsin-like and retroviral aspartic proteinases.
Advances in experimental medicine and biology 1991;306():443-53.
1991: Hoover D J; Veerapandian B; Cooper J B; Damon D B; Dominy B W; Rosati R L; Blundell T L
X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin.
Advances in experimental medicine and biology 1991;306():269-73.
1990: Veerapandian B; Cooper J B; Sali A; Blundell T L
X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution.
Journal of molecular biology 1990;216(4):1017-29.
1990: Blundell T L; Lapatto R; Wilderspin A F; Hemmings A M; Hobart P M; Danley D E; Whittle P J
The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS.
Trends in biochemical sciences 1990;15(11):425-30.
1990: Bax B; Lapatto R; Nalini V; Driessen H; Lindley P F; Mahadevan D; Blundell T L; Slingsby C
X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins.
Nature 1990;347(6295):776-80.
1990: Cooper J B; Khan G; Taylor G; Tickle I J; Blundell T L
X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution.
Journal of molecular biology 1990;214(1):199-222.
1990: Sali A; Overington J P; Johnson M S; Blundell T L
From comparisons of protein sequences and structures to protein modelling and design.
Trends in biochemical sciences 1990;15(6):235-40.
1990: Husain J; Blundell T L; Cooper S; Pitts J E; Tickle I J; Wood S P; Hruby V J; Buku A; Fischman A J; Wyssbrod H R
The conformation of deamino-oxytocin: X-ray analysis of the 'dry' and 'wet' forms.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1990;327(1243):625-54.
1990: Sali A; Blundell T L
Definition of general topological equivalence in protein structures. A procedure involving comparison of properties and relationships through simulated annealing and dynamic programming.
Journal of molecular biology 1990;212(2):403-28.
1990: Blundell T L; Jenkins J A; Sewell B T; Pearl L H; Cooper J B; Tickle I J; Veerapandian B; Wood S P
X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin.
Journal of molecular biology 1990;211(4):919-41.
1990: Johnson M S; Sutcliffe M J; Blundell T L
Molecular anatomy: phyletic relationships derived from three-dimensional structures of proteins.
Journal of molecular evolution 1990;30(1):43-59.
1990: McDonald N Q; Lapatto R; Murray-Rust J; Blundell T L
X-ray crystallographic studies on murine nerve growth factor.
Journal of cell science. Supplement 1990;13():19-30.
1989: Lapatto R; Blundell T; Hemmings A; Overington J; Wilderspin A; Wood S; Merson J R; Whittle P J; Danley D E; Geoghegan K F
X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes.
Nature 1989;342(6247):299-302.
1989: Cooper J B; Foundling S I; Blundell T L; Boger J; Jupp R A; Kay J
X-ray studies of aspartic proteinase-statine inhibitor complexes.
Biochemistry 1989;28(21):8596-603.
1989: Sali A; Veerapandian B; Cooper J B; Foundling S I; Hoover D J; Blundell T L
High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme.
The EMBO journal 1989;8(8):2179-88.
1989: Blundell T L; Elliott G; Gardner S P; Hubbard T; Islam S; Johnson M; Mantafounis D; Murray-Rust P; Overington J; Pitts J E
Protein engineering and design.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1989;324(1224):447-60.
1989: Donnelly D; Johnson M S; Blundell T L; Saunders J
An analysis of the periodicity of conserved residues in sequence alignments of G-protein coupled receptors. Implications for the three-dimensional structure.
FEBS letters 1989;251(1-2):109-16.
1989: Sibanda B L; Blundell T L; Thornton J M
Conformation of beta-hairpins in protein structures. A systematic classification with applications to modelling by homology, electron density fitting and protein engineering.
Journal of molecular biology 1989;206(4):759-77.
1988: Wood S P; Oliva G; O'Hara B P; White H E; Blundell T L; Perkins S J; Sardharwalla I; Pepys M B
A pentameric form of human serum amyloid P component. Crystallization, X-ray diffraction and neutron scattering studies.
Journal of molecular biology 1988;202(1):169-73.
1988: Slingsby C; Driessen H P; Mahadevan D; Bax B; Blundell T L
Evolutionary and functional relationships between the basic and acidic beta-crystallins.
Experimental eye research 1988;46(3):375-403.
1988: Blundell T; Carney D; Gardner S; Hayes F; Howlin B; Hubbard T; Overington J; Singh D A; Sibanda B L; Sutcliffe M
18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design.
European journal of biochemistry / FEBS 1988;172(3):513-20.
1987: Luchin S V; Zinovieva R D; Tomarev S I; Dolgilevich S M; Gause G G; Bax B; Driessen H; Blundell T L
Frog lens beta A1-crystallin: the nucleotide sequence of the cloned cDNA and computer graphics modelling of the three-dimensional structure.
Biochimica et biophysica acta 1987;916(2):163-71.
1987: Cooper J; Foundling S; Hemmings A; Blundell T; Jones D M; Hallett A; Szelke M
The structure of a synthetic pepsin inhibitor complexed with endothiapepsin.
European journal of biochemistry / FEBS 1987;169(1):215-21.
1987: Sutcliffe M J; Hayes F R; Blundell T L
Knowledge based modelling of homologous proteins, Part II: Rules for the conformations of substituted sidechains.
Protein engineering 1987;1(5):385-92.
1987: Sutcliffe M J; Haneef I; Carney D; Blundell T L
Knowledge based modelling of homologous proteins, Part I: Three-dimensional frameworks derived from the simultaneous superposition of multiple structures.
Protein engineering 1987;1(5):377-84.
1987: Blundell T L; Cooper J; Foundling S I; Jones D M; Atrash B; Szelke M
On the rational design of renin inhibitors: X-ray studies of aspartic proteinases complexed with transition-state analogues.
Biochemistry 1987;26(18):5585-90.
1987: Cooper J B; Foundling S I; Hemmings A; Watson F E; Sibanda B L; Blundell T L; Jones D M; Hallett A; Atrash B; Szelke M
Inhibitors of aspartic proteinases and their relevance to the design of antihypertensive agents.
Biochemical Society transactions 1987;15(4):751-4.
1987: Hubbard T J; Blundell T L
Comparison of solvent-inaccessible cores of homologous proteins: definitions useful for protein modelling.
Protein engineering 1987;1(3):159-71.
1987: Foundling S I; Cooper J; Watson F E; Cleasby A; Pearl L H; Sibanda B L; Hemmings A; Wood S P; Blundell T L; Valler M J
High resolution X-ray analyses of renin inhibitor-aspartic proteinase complexes.
Nature 1987;327(6120):349-52.
1987: Foundling S I; Cooper J; Watson F E; Pearl L H; Hemmings A; Wood S P; Blundell T; Hallett A; Jones D M; Sueiras J
Crystallographic studies of reduced bond inhibitors complexed with an aspartic proteinase.
Journal of cardiovascular pharmacology 1987;10 Suppl 7():S59-68.
1986: Summers L J; Blundell T L; Gause G G; Tomarev S I
A computer graphics model of frog gamma-crystallin based on the three-dimensional structure of calf gamma-II crystallin.
FEBS letters 1986;208(1):11-6.
1986: Summers L J; Slingsby C; Blundell T L; den Dunnen J T; Moormann R J; Schoenmakers J G
Structural variation in mammalian gamma-crystallins based on computer graphics analyses of human, rat and calf sequences. 1. Core packing and surface properties.
Experimental eye research 1986;43(1):77-92.
1986: Wood S P; Tickle I J; Treharne A M; Pitts J E; Mascarenhas Y; Li J Y; Husain J; Cooper S; Blundell T L; Hruby V J
Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding.
Science (New York, N.Y.) 1986;232(4750):633-6.
1985: Hemmings A M; Foundling S I; Sibanda B L; Wood S P; Pearl L H; Blundell T
Energy calculations on aspartic proteinases: human renin, endothiapepsin and its complex with an angiotensinogen fragment analogue, H-142.
Biochemical Society transactions 1985;13(6):1036-41.
1985: Wistow G; Summers L; Blundell T
Myxococcus xanthus spore coat protein S may have a similar structure to vertebrate lens beta gamma-crystallins.
Nature 1985;315(6022):771-3.
1984: Sibanda B L; Blundell T; Hobart P M; Fogliano M; Bindra J S; Dominy B W; Chirgwin J M
Computer graphics modelling of human renin. Specificity, catalytic activity and intron-exon junctions.
FEBS letters 1984;174(1):102-11.
1984: Summers L; Slingsby C; White H; Narebor M; Moss D; Miller L; Mahadevan D; Lindley P; Driessen H; Blundell T
The molecular structures and interactions of bovine and human gamma-crystallins.
Ciba Foundation symposium 1984;106():219-36.
1983: Wistow G; Turnell B; Summers L; Slingsby C; Moss D; Miller L; Lindley P; Blundell T
X-ray analysis of the eye lens protein gamma-II crystallin at 1.9 A resolution.
Journal of molecular biology 1983;170(1):175-202.
1983: Blundell T; Sibanda B L; Pearl L
Three-dimensional structure, specificity and catalytic mechanism of renin.
Nature 1983;304(5923):273-5.
1981: Blundell T; Lindley P; Miller L; Moss D; Slingsby C; Tickle I; Turnell B; Wistow G
The molecular structure and stability of the eye lens: x-ray analysis of gamma-crystallin II.
Nature 1981;289(5800):771-7.

Sign-in to see more