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Margaret Shuhart

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Zhican Wang; Connie L Davis; Leslie J Dickmann; David L Eaton; Johanna W Lampe; Yvonne S Lin; Emma-Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Emma Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel; Julia Tracy; Johanna W Lampe; Lisa Levy; David L Eaton
Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Angela L Rasmussen; Chris Roberts; Margaret C Shuhart; Lisa V Thomassen; Roger Ulrich; I-Ming Wang; Christopher M Williams; Janine T Bryan; Victoria S Carter; Razvan Cristescu; Deborah L Diamond; Yudong He; Marcus J Korth; Sean C Proll; Michael G Katze
Chronic immune activation is a distinguishing feature of liver and PBMC gene signatures from HCV/HIV coinfected patients and may contribute to hepatic fibrogenesis.

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All Publications

2013: Zhican Wang; Connie L Davis; Leslie J Dickmann; David L Eaton; Johanna W Lampe; Yvonne S Lin; Emma-Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel
Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for drug-induced osteomalacia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013;28(5):1101-16.
2013: Emma Jane Poulton; Danny D Shen; Margaret C Shuhart; Kenneth E Thummel; Julia Tracy; Johanna W Lampe; Lisa Levy; David L Eaton
Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo.
Toxicology and applied pharmacology 2013;266(1):122-31.
2012: Angela L Rasmussen; Chris Roberts; Margaret C Shuhart; Lisa V Thomassen; Roger Ulrich; I-Ming Wang; Christopher M Williams; Janine T Bryan; Victoria S Carter; Razvan Cristescu; Deborah L Diamond; Yudong He; Marcus J Korth; Sean C Proll; Michael G Katze
Chronic immune activation is a distinguishing feature of liver and PBMC gene signatures from HCV/HIV coinfected patients and may contribute to hepatic fibrogenesis.
Virology 2012;430(1):43-52.
2012: Xi Emily Zheng; Zhican Wang; Michael Z Liao; Yvonne S Lin; Erin G Schuetz; Margaret C Shuhart; Kenneth E Thummel
Human PXR-mediated induction of intestinal CYP3A4 attenuates 1α,25-dihydroxyvitamin D₃ function in human colon adenocarcinoma LS180 cells.
Biochemical pharmacology 2012;84(3):391-401.
2011: A G Singal; Lisa V Thomassen; David R Gretch; Margaret C Shuhart
Use of the AST to platelet ratio index in HCV/HIV co-infected patients.
Alimentary pharmacology & therapeutics 2011;33(5):566-77.
2010: Chihiro Morishima; Margaret C Shuhart; Chia C Wang; Denise M Paschal; Minjun C Apodaca; Yanze Liu; Derek D Sloan; Tyler N Graf; Nicholas H Oberlies; David Y W Lee; Keith R Jerome; Stephen J Polyak
Silymarin inhibits in vitro T-cell proliferation and cytokine production in hepatitis C virus infection.
Gastroenterology 2010;138(2):671-81, 681.e1-2.
2009: D J McConn; Yvonne S Lin; T L Mathisen; D K Blough; Y Xu; T Hashizume; S L Taylor; Kenneth E Thummel; Margaret C Shuhart
Reduced duodenal cytochrome P450 3A protein expression and catalytic activity in patients with cirrhosis.
Clinical pharmacology and therapeutics 2009;85(4):387-93.
2008: Chia C Wang; Lei Y Lim; Heike Deubner; Kenneth Tapia; Agnes W Y Lau; Jaime Manansala; Meighan Krows; Margaret C Shuhart; Kris V Kowdley
Factors predictive of significant hepatic fibrosis in adults with chronic hepatitis B and normal serum ALT.
Journal of clinical gastroenterology 2008;42(7):820-6.
2008: Takanori Hashizume; Yang Xu; Michael A Mohutsky; Jeffrey Alberts; Chad Hadden; Thomas F Kalhorn; Nina Isoherranen; Margaret C Shuhart; Kenneth E Thummel
Identification of human UDP-glucuronosyltransferases catalyzing hepatic 1alpha,25-dihydroxyvitamin D3 conjugation.
Biochemical pharmacology 2008;75(5):1240-50.
2007: H Nina Kim; Robert D Harrington; Margaret C Shuhart; Linda Cook; Chihiro Morishima; Keith R Jerome; Chia C Wang
Hepatitis C virus activation in HIV-infected patients initiating highly active antiretroviral therapy.
AIDS patient care and STDs 2007;21(10):718-23.
2007: Chihiro Morishima; Margaret C Shuhart; Christina S Yoshihara; Denise M Paschal; Melissa A Silva; Lisa V Thomassen; Scott S Emerson; David R Gretch
Preservation of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses despite global loss of CD4+ T cells in HCV/HIV coinfection.
The Journal of infectious diseases 2007;196(4):577-86.
2007: Stephen Polyak; Chihiro Morishima; Margaret C Shuhart; Chia C Wang; Yanze Liu; David Y W Lee
Inhibition of T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection by standardized Silymarin.
Gastroenterology 2007;132(5):1925-36.
2006: Raymond Cheng; Verena S Grieco; Margaret C Shuhart; Stephen J Rulyak
EUS-guided FNA diagnosis of pancreatic tuberculosis.
Gastrointestinal endoscopy 2006;64(4):660-3.
2006: Kathie-Anne Walters; Maria W Smith; Sampa Pal; Jill C Thompson; Matthew J Thomas; Matthew M Yeh; David L Thomas; Matthew Fitzgibbon; Sean C Proll; Nelson Fausto; David R Gretch; Robert L Carithers; Margaret C Shuhart; Michael G Katze
Identification of a specific gene expression pattern associated with HCV-induced pathogenesis in HCV- and HCV/HIV-infected individuals.
Virology 2006;350(2):453-64.
2006: Margaret C Shuhart; Daniel G Sullivan; Kirubeal Bekele; Robert D Harrington; Mari M Kitahata; Terri L Mathisen; Lisa V Thomassen; Scott S Emerson; David R Gretch
HIV infection and antiretroviral therapy: effect on hepatitis C virus quasispecies variability.
The Journal of infectious diseases 2006;193(9):1211-8.
2006: Chihiro Morishima; Denise M Paschal; Chia C Wang; Christina S Yoshihara; Brent L Wood; Anthony E T Yeo; Scott S Emerson; Margaret C Shuhart; David R Gretch
Decreased NK cell frequency in chronic hepatitis C does not affect ex vivo cytolytic killing.
Hepatology (Baltimore, Md.) 2006;43(3):573-80.
2006: Sampa Pal; Margaret C Shuhart; Lisa V Thomassen; Scott S Emerson; Tao Su; Nathan Feuerborn; John Kae; David R Gretch
Intrahepatic hepatitis C virus replication correlates with chronic hepatitis C disease severity in vivo.
Journal of virology 2006;80(5):2280-90.
2006: Maria W Smith; Kathie-Anne Walters; Marcus J Korth; Matthew Fitzgibbon; Sean C Proll; Jill C Thompson; Matthew M Yeh; Margaret C Shuhart; Jeffrey C Furlong; Paula P Cox; David L Thomas; John D Phillips; James P Kushner; Nelson Fausto; Robert L Carithers; Michael G Katze
Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients.
Gastroenterology 2006;130(1):179-87.
2006: Yang Xu; Takanori Hashizume; Margaret C Shuhart; Connie L Davis; Wendel L Nelson; Toshiyuki Sakaki; Thomas F Kalhorn; Paul B Watkins; Erin G Schuetz; Kenneth E Thummel
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
Molecular pharmacology 2006;69(1):56-65.
2005: Stephen Polyak; Daniel G Sullivan; Michael A Austin; James Y Dai; Margaret C Shuhart; Karen L Lindsay; Herbert L Bonkovsky; Adrian M Di Bisceglie; William M Lee; Chihiro Morishima; David R Gretch
Comparison of amplification enzymes for Hepatitis C Virus quasispecies analysis.
Virology journal 2005;2():41.
2004: Chia C Wang; Sarah Holte; Meei-Li Huang; Stephen L Sacks; Ruth A Engelberg; James Ferrenberg; Margaret C Shuhart; Lawrence Corey
Kinetics of hepatitis B viral load during 48 weeks of treatment with 600 mg vs 100 mg of lamivudine daily.
Journal of viral hepatitis 2004;11(5):443-7.
2003: Renuka Bhattacharya; Margaret C Shuhart
Hepatitis C and alcohol: interactions, outcomes, and implications.
Journal of clinical gastroenterology 2003;36(3):242-52.
1998: Margaret C Shuhart; Kris V Kowdley; John P McVicar; Charles A Rohrmann; M F McDonald; D W Wadland; Scott S Emerson; Robert L Carithers; Michael B Kimmey
Predictors of bile leaks after T-tube removal in orthotopic liver transplant recipients.
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1998;4(1):62-70.
1997: Margaret C Shuhart; Mary P Bronner; David R Gretch; Lisa V Thomassen; CF Wartelle; H Tateyama; Scott S Emerson; J D Perkins; Robert L Carithers
Histological and clinical outcome after liver transplantation for hepatitis C.
Hepatology (Baltimore, Md.) 1997;26(6):1646-52.