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Arti Shukla

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Brooke T Mossman; Arti Shukla; Anish Thomas; Claire F Verschraegen; Nicholas H Heintz; Raffit Hassan
New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.
Sherrill L Macura; Timothy N Perkins; Mutlay Sayan; Arti Shukla; Jeremy L Steinbacher; Douglas J Taatjes; Stacie L Beuschel; Kelly J Butnor; Khan Hekmatyar; Jedd M Hillegass; Risto A Kauppinen; Christopher C Landry; Melissa J Lathrop; Maximilian B MacPherson; Brooke T Mossman
A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas.
Kheng Newick; Harvey I Pass; Kelsey Preston; Arti Shukla; Jack Arbiser; Brian Cunniff; Paul Held; Brooke Mossman; Nicholas Heintz
Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells.

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All Publications

2013: Brooke T Mossman; Arti Shukla; Anish Thomas; Claire F Verschraegen; Nicholas H Heintz; Raffit Hassan
New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.
The American journal of pathology 2013;182(4):1065-77.
2012: Sherrill L Macura; Timothy N Perkins; Mutlay Sayan; Arti Shukla; Jeremy L Steinbacher; Douglas J Taatjes; Stacie L Beuschel; Kelly J Butnor; Khan Hekmatyar; Jedd M Hillegass; Risto A Kauppinen; Christopher C Landry; Melissa J Lathrop; Maximilian B MacPherson; Brooke T Mossman
A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012;60(9):658-74.
2012: Kheng Newick; Harvey I Pass; Kelsey Preston; Arti Shukla; Jack Arbiser; Brian Cunniff; Paul Held; Brooke Mossman; Nicholas Heintz
Peroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cells.
PloS one 2012;7(6):e39404.
2012: Timothy N Perkins; Niki L Reynaert; Arti Shukla; Chad Steele; Jeremy L Steinbacher; Emiel F M Wouters; Christopher C Landry; Sherrill A Lathrop; Paul M Peeters; Brooke T Mossman
Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells.
Particle and fibre toxicology 2012;9(1):6.
2011: Arti Shukla; William A Swain; Joseph R Testa; Kenneth J O'Byrne; Harvey I Pass; Trisha F Barrett; Stephen P Faux; Naomi K Fukagawa; Jedd M Hillegass; Maximmilian MacPherson; Brooke T Mossman
An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.
American journal of respiratory cell and molecular biology 2011;45(5):906-14.
2011: Arti Shukla; Joseph R Testa; Pamela M Vacek; Harvey I Pass; Stacie L Beuschel; Kelly J Butnor; Michele Carbone; Nicholas H Heintz; Jedd M Hillegass; Maximilian B MacPherson; Brooke T Mossman
ERK2 is essential for the growth of human epithelioid malignant mesotheliomas.
International journal of cancer. Journal international du cancer 2011;129(5):1075-86.
2011: Jedd M Hillegass; Steven R Blumen; Kai Cheng; Maximilian B MacPherson; Vlada Alexeeva; Sherrill A Lathrop; Stacie L Beuschel; Jeremy L Steinbacher; Kelly J Butnor; Maria E Ramos-Niño; Arti Shukla; Ted A James; Daniel J Weiss; Douglas J Taatjes; Harvey I Pass; Michele Carbone; Christopher C Landry; Brooke T Mossman
Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy.
International journal of cancer. Journal international du cancer 2011;129(1):233-44.
2010: Jedd M Hillegass; Arti Shukla; Sherrill A Lathrop; Maximilian B MacPherson; Stacie L Beuschel; Kelly J Butnor; Joseph R Testa; Harvey I Pass; Michele Carbone; Chad Steele; Brooke T Mossman
Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model.
Annals of the New York Academy of Sciences 2010;1203():7-14.
2010: Jedd M Hillegass; Arti Shukla; Sherrill A Lathrop; Maximilian B MacPherson; Naomi K Fukagawa; Brooke T Mossman
Assessing nanotoxicity in cells in vitro.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2010;2(3):219-31.
2010: Arti Shukla; Jedd M Hillegass; Maximilian B MacPherson; Stacie L Beuschel; Pamela M Vacek; Harvey I Pass; Michele Carbone; Joseph R Testa; Brooke T Mossman
Blocking of ERK1 and ERK2 sensitizes human mesothelioma cells to doxorubicin.
Molecular cancer 2010;9():314.
2010: Jedd M Hillegass; Arti Shukla; Maximilian B MacPherson; Sherrill A Lathrop; Vlada Alexeeva; Timothy N Perkins; Albert van der Vliet; Pamela M Vacek; Mickey E Gunter; Brooke T Mossman
Mechanisms of oxidative stress and alterations in gene expression by Libby six-mix in human mesothelial cells.
Particle and fibre toxicology 2010;7():26.
2010: Jedd M Hillegass; Arti Shukla; Maximilian B MacPherson; Jeffrey P Bond; Chad Steele; Brooke T Mossman
Utilization of gene profiling and proteomics to determine mineral pathogenicity in a human mesothelial cell line (LP9/TERT-1).
Journal of toxicology and environmental health. Part A 2010;73(5):423-36.
2009: Arti Shukla; Marcus W Bosenberg; Maximmilian MacPherson; Kelly J Butnor; Nicholas H Heintz; Harvey I Pass; Michele Carbone; Joseph R Testa; Brooke T Mossman
Activated cAMP response element binding protein is overexpressed in human mesotheliomas and inhibits apoptosis.
The American journal of pathology 2009;175(5):2197-206.
2009: Arti Shukla; Maximmilian MacPherson; Jedd Hillegass; Maria E Ramos-Nino; Vlada Alexeeva; Pamela M Vacek; Jeffrey P Bond; Harvey I Pass; Chad Steele; Brooke T Mossman
Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity.
American journal of respiratory cell and molecular biology 2009;41(1):114-23.
2009: SA Buder-Hoffmann; Arti Shukla; Trisha F Barrett; Maximmilian MacPherson; Karen M Lounsbury; Brooke T Mossman
A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos.
The American journal of pathology 2009;174(2):449-59.
2007: Brooke T Mossman; Arti Shukla; Naomi K Fukagawa
Highlight Commentary on "Oxidative stress and lipid mediators induced in alveolar macrophages by ultrafine particles".
Free radical biology & medicine 2007;43(4):504-5.
2007: Christy A Barlow; Trisha F Barrett; Arti Shukla; Brooke T Mossman; Karen M Lounsbury
Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.
American journal of physiology. Lung cellular and molecular physiology 2007;292(6):L1361-9.
2007: Astrid Haegens; Trisha F Barrett; Joanna Gell; Arti Shukla; Maximmilian MacPherson; Pamela M Vacek; Matthew E Poynter; Kelly J Butnor; Yvonne M W Janssen-Heininger; Chad Steele; Brooke T Mossman
Airway epithelial NF-kappaB activation modulates asbestos-induced inflammation and mucin production in vivo.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(3):1800-8.
2007: Arti Shukla; Karen M Lounsbury; Trisha F Barrett; Joanna Gell; Mercedes Rincon; Kelly J Butnor; Douglas J Taatjes; Gerald S Davis; Pamela M Vacek; Keiichi I Nakayama; Keiko Nakayama; Chad Steele; Brooke T Mossman
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.
The American journal of pathology 2007;170(1):140-51.
2006: Arti Shukla; Trisha F Barrett; Keiichi I Nakayama; Kieko Nakayama; Brooke T Mossman; Karen M Lounsbury
Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCdelta-dependent pathway in murine lung.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(7):997-9.
2006: Christy A Barlow; Arti Shukla; Brooke T Mossman; Karen M Lounsbury
Oxidant-mediated cAMP response element binding protein activation: calcium regulation and role in apoptosis of lung epithelial cells.
American journal of respiratory cell and molecular biology 2006;34(1):7-14.
2004: Arti Shukla; Trisha Flanders; Karen M Lounsbury; Brooke T Mossman
The gamma-glutamylcysteine synthetase and glutathione regulate asbestos-induced expression of activator protein-1 family members and activity.
Cancer research 2004;64(21):7780-6.
2004: Arti Shukla; Pamela Vacek; Brooke T Mossman
Dose-Response Relationships in Expression of Biomarkers of Cell Proliferation in in vitro Assays and Inhalation Experiments.
Nonlinearity in biology, toxicology, medicine 2004;2(2):117-28.
2003: Muyao Li; Brooke T Mossman; Emily Kolpa; Cynthia R Timblin; Arti Shukla; Douglas J Taatjes; Naomi K Fukagawa
Age-related differences in MAP kinase activity in VSMC in response to glucose or TNF-alpha.
Journal of cellular physiology 2003;197(3):418-25.
2003: Arti Shukla; Michael Jung; Maria Stern; Naomi K Fukagawa; Douglas J Taatjes; Dennis Sawyer; Bennett Van Houten; Brooke T Mossman
Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.
American journal of physiology. Lung cellular and molecular physiology 2003;285(5):L1018-25.
2003: Arti Shukla; Maria E Ramos-Nino; Brooke T Mossman
Cell signaling and transcription factor activation by asbestos in lung injury and disease.
The international journal of biochemistry & cell biology 2003;35(8):1198-209.
2003: Arti Shukla; Maria Stern; Karen M Lounsbury; Trisha Flanders; Brooke T Mossman
Asbestos-induced apoptosis is protein kinase C delta-dependent.
American journal of respiratory cell and molecular biology 2003;29(2):198-205.
2003: Arti Shukla; Mary Gulumian; Tom K Hei; David Kamp; Qamar Rahman; Brooke T Mossman
Multiple roles of oxidants in the pathogenesis of asbestos-induced diseases.
Free radical biology & medicine 2003;34(9):1117-29.
2002: Maria E Ramos-Nino; Astrid Haegens; Arti Shukla; Brooke T Mossman
Role of mitogen-activated protein kinases (MAPK) in cell injury and proliferation by environmental particulates.
Molecular and cellular biochemistry 2002;234-235(1-2):111-8.
2002: Andrea K Hubbard; Cynthia R Timblin; Arti Shukla; Mercedes Rincón; Brooke T Mossman
Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L968-75.
2002: Cynthia R Timblin; Arti Shukla; Ingrid Berlanger; Kelly A BeruBe; Andrew Churg; Brooke T Mossman
Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells.
Toxicology and applied pharmacology 2002;179(2):98-104.
2001: Arti Shukla; Cynthia R Timblin; Andrea K Hubbard; J Bravman; Brooke T Mossman
Silica-induced activation of c-Jun-NH2-terminal amino kinases, protracted expression of the activator protein-1 proto-oncogene, fra-1, and S-phase alterations are mediated via oxidative stress.
Cancer research 2001;61(5):1791-5.
2000: Arti Shukla; Cynthia R Timblin; Kelly A BeruBe; T Gordon; willie mckinney; Kevin E Driscoll; Pamela M Vacek; Brooke T Mossman
Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro.
American journal of respiratory cell and molecular biology 2000;23(2):182-7.
2000: GS Shukla; Arti Shukla; Ryan J Potts; M Osier; Beth A Hart; Jen-Fu Chiu
Cadmium-mediated oxidative stress in alveolar epithelial cells induces the expression of gamma-glutamylcysteine synthetase catalytic subunit and glutathione S-transferase alpha and pi isoforms: potential role of activator protein-1.
Cell biology and toxicology 2000;16(6):347-62.
1999: Beth A Hart; C H Lee; GS Shukla; Arti Shukla; M Osier; Jonathan D Eneman; Jen-Fu Chiu
Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress.
Toxicology 1999;133(1):43-58.