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Gerald Shulman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Glucose Clamp Technique

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Publications

TOP 3
Leavens Karla F; Easton Rachael M; Shulman Gerald I; Previs Stephen F; Birnbaum Morris J
Akt2 is required for hepatic lipid accumulation in models of insulin resistance.
Liu Li; Shi Xiaojing; Choi Cheol Soo; Shulman Gerald I; Klaus Katherine; Nair K Sreekumaran; Schwartz Gary J; Zhang Yiying; Goldberg Ira J; Yu Yi-Hao
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.
Li Lei O; Ellis Jessica M; Paich Heather A; Wang Shuli; Gong Nan; Altshuller George; Thresher Randy J; Koves Timothy R; Watkins Steven M; Muoio Deborah M; Cline Gary W; Shulman Gerald I; Coleman Rosalind A
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.

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All Publications

2009: Leavens Karla F; Easton Rachael M; Shulman Gerald I; Previs Stephen F; Birnbaum Morris J
Akt2 is required for hepatic lipid accumulation in models of insulin resistance.
Cell metabolism 2009;10(5):405-18.
2009: Liu Li; Shi Xiaojing; Choi Cheol Soo; Shulman Gerald I; Klaus Katherine; Nair K Sreekumaran; Schwartz Gary J; Zhang Yiying; Goldberg Ira J; Yu Yi-Hao
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.
Diabetes 2009;58(11):2516-24.
2009: Li Lei O; Ellis Jessica M; Paich Heather A; Wang Shuli; Gong Nan; Altshuller George; Thresher Randy J; Koves Timothy R; Watkins Steven M; Muoio Deborah M; Cline Gary W; Shulman Gerald I; Coleman Rosalind A
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.
The Journal of biological chemistry 2009;284(41):27816-26.
2009: Stark Romana; Pasquel Francisco; Turcu Adina; Pongratz Rebecca L; Roden Michael; Cline Gary W; Shulman Gerald I; Kibbey Richard G
Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.
The Journal of biological chemistry 2009;284(39):26578-90.
2009: Samuel Varman T; Beddow Sara A; Iwasaki Takanori; Zhang Xian-Man; Chu Xin; Still Christopher D; Gerhard Glenn S; Shulman Gerald I
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12121-6.
2009: Erion Derek M; Yonemitsu Shin; Nie Yongzhan; Nagai Yoshio; Gillum Matthew P; Hsiao Jennifer J; Iwasaki Takanori; Stark Romana; Weismann Dirk; Yu Xing Xian; Murray Susan F; Bhanot Sanjay; Monia Brett P; Horvath Tamas L; Gao Qian; Samuel Varman T; Shulman Gerald I
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11288-93.
2009: Dufour Sylvie; Lebon Vincent; Shulman Gerald I; Petersen Kitt Falk
Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E231-5.
2009: Estall Jennifer L; Kahn Mario; Cooper Marcus P; Fisher Ffolliott Martin; Wu Michele K; Laznik Dina; Qu Lishu; Cohen David E; Shulman Gerald I; Spiegelman Bruce M
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Diabetes 2009;58(7):1499-508.
2009: Pongratz Rebecca L; Kibbey Richard G; Kirkpatrick Clare L; Zhao Xiaojian; Pontoglio Marco; Yaniv Moshe; Wollheim Claes B; Shulman Gerald I; Cline Gary W
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
The Journal of biological chemistry 2009;284(25):16808-21.
2009: Nie Yongzhan; Erion Derek M; Yuan Zhenglong; Dietrich Marcelo; Shulman Gerald I; Horvath Tamas L; Gao Qian
STAT3 inhibition of gluconeogenesis is downregulated by SirT1.
Nature cell biology 2009;11(4):492-500.
2009: Ahmadian Maryam; Duncan Robin E; Varady Krista A; Frasson Danubia; Hellerstein Marc K; Birkenfeld Andreas L; Samuel Varman T; Shulman Gerald I; Wang Yuhui; Kang Chulho; Sul Hei Sook
Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.
Diabetes 2009;58(4):855-66.
2009: Nagai Yoshio; Yonemitsu Shin; Erion Derek M; Iwasaki Takanori; Stark Romana; Weismann Dirk; Dong Jianying; Zhang Dongyan; Jurczak Michael J; Löffler Michael G; Cresswell James; Yu Xing Xian; Murray Susan F; Bhanot Sanjay; Monia Brett P; Bogan Jonathan S; Samuel Varman; Shulman Gerald I
The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.
Cell metabolism 2009;9(3):252-64.
2009: Jaworski Kathy; Ahmadian Maryam; Duncan Robin E; Sarkadi-Nagy Eszter; Varady Krista A; Hellerstein Marc K; Lee Hui-Young; Samuel Varman T; Shulman Gerald I; Kim Kee-Hong; de Val Sarah; Kang Chulho; Sul Hei Sook
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Nature medicine 2009;15(2):159-68.
2009: Wang Hong; Knaub Leslie A; Jensen Dalan R; Young Jung Dae; Hong Eun-Gyoung; Ko Hwi-Jin; Coates Alison M; Goldberg Ira J; de la Houssaye Becky A; Janssen Rachel C; McCurdy Carrie E; Rahman Shaikh M; Soo Choi Cheol; Shulman Gerald I; Kim Jason K; Friedman Jacob E; Eckel Robert H
Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.
Diabetes 2009;58(1):116-24.
2009: Rowe Glenn C; Choi Cheol Soo; Neff Lynn; Horne William C; Shulman Gerald I; Baron Roland
Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.
Endocrinology 2009;150(1):135-43.
2009: Befroy Douglas E; Falk Petersen Kitt; Rothman Douglas L; Shulman Gerald I
Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy.
Methods in enzymology 2009;457():373-93.
2008: Villena Josep A; Choi Cheol Soo; Wang Yuhui; Kim Sheene; Hwang Yu-Jin; Kim Young-Bum; Cline Gary; Shulman Gerald I; Sul Hei Sook
Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy.
Diabetes 2008;57(12):3258-66.
2008: Gillum Matthew P; Zhang Dongyan; Zhang Xian-Man; Erion Derek M; Jamison Rachel A; Choi Cheolsoo; Dong Jianying; Shanabrough Marya; Duenas Hillary R; Frederick David W; Hsiao Jennifer J; Horvath Tamas L; Lo Chun Min; Tso Pat; Cline Gary W; Shulman Gerald I
N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.
Cell 2008;135(5):813-24.
2008: Befroy Douglas E; Petersen Kitt Falk; Dufour Sylvie; Mason Graeme F; Rothman Douglas L; Shulman Gerald I
Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16701-6.
2008: Morino Katsutaro; Neschen Susanne; Bilz Stefan; Sono Saki; Tsirigotis Dimitrios; Reznick Richard M; Moore Irene; Nagai Yoshio; Samuel Varman; Sebastian David; White Morris; Philbrick William; Shulman Gerald I
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
Diabetes 2008;57(10):2644-51.
2008: Andrews Zane B; Liu Zhong-Wu; Walllingford Nicholas; Erion Derek M; Borok Erzsebet; Friedman Jeffery M; Tschöp Matthias H; Shanabrough Marya; Cline Gary; Shulman Gerald I; Coppola Anna; Gao Xiao-Bing; Horvath Tamas L; Diano Sabrina
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Nature 2008;454(7206):846-51.
2008: Essop M Faadiel; Camp Heidi S; Choi Cheol Soo; Sharma Saumya; Fryer Ryan M; Reinhart Glenn A; Guthrie Patrick H; Bentebibel Assia; Gu Zeiwei; Shulman Gerald I; Taegtmeyer Heinrich; Wakil Salih J; Abu-Elheiga Lutfi
Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H256-65.
2008: Wolfgang Michael J; Cha Seung Hun; Millington David S; Cline Gary; Shulman Gerald I; Suwa Akira; Asaumi Makoto; Kurama Takeshi; Shimokawa Teruhiko; Lane M Daniel
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.
Journal of neurochemistry 2008;105(4):1550-9.
2008: Kim Hyeonjin; Taksali Sara E; Dufour Sylvie; Befroy Douglas; Goodman T Robin; Petersen Kitt Falk; Shulman Gerald I; Caprio Sonia; Constable R Todd
Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(3):521-7.
2008: Danial Nika N; Walensky Loren D; Zhang Chen-Yu; Choi Cheol Soo; Fisher Jill K; Molina Anthony J A; Datta Sandeep Robert; Pitter Kenneth L; Bird Gregory H; Wikstrom Jakob D; Deeney Jude T; Robertson Kirsten; Morash Joel; Kulkarni Ameya; Neschen Susanne; Kim Sheene; Greenberg Michael E; Corkey Barbara E; Shirihai Orian S; Shulman Gerald I; Lowell Bradford B; Korsmeyer Stanley J
Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Nature medicine 2008;14(2):144-53.
2008: Savage David B; Zhai Lanmin; Ravikumar Balasubramanian; Choi Cheol Soo; Snaar Johanna E; McGuire Amanda C; Wou Sung-Eun; Medina-Gomez Gemma; Kim Sheene; Bock Cheryl B; Segvich Dyann M; Solanky Bhavana; Deelchand Dinesh; Vidal-Puig Antonio; Wareham Nicholas J; Shulman Gerald I; Karpe Fredrik; Taylor Roy; Pederson Bartholomew A; Roach Peter J; O'Rahilly Stephen; DePaoli-Roach Anna A
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
PLoS medicine 2008;5(1):e27.
2007: Wolfgang Michael J; Cha Seung Hun; Sidhaye Aniket; Chohnan Shigeru; Cline Gary; Shulman Gerald I; Lane M Daniel
Regulation of hypothalamic malonyl-CoA by central glucose and leptin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19285-90.
2007: Handschin Christoph; Choi Cheol Soo; Chin Sherry; Kim Sheene; Kawamori Dan; Kurpad Amarnath J; Neubauer Nicole; Hu Jiang; Mootha Vamsi K; Kim Young-Bum; Kulkarni Rohit N; Shulman Gerald I; Spiegelman Bruce M
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
The Journal of clinical investigation 2007;117(11):3463-74.
2007: Zhang Dongyan; Liu Zhen-Xiang; Choi Cheol Soo; Tian Liqun; Kibbey Richard; Dong Jianying; Cline Gary W; Wood Philip A; Shulman Gerald I
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17075-80.
2007: Choi Cheol Soo; Savage David B; Abu-Elheiga Lutfi; Liu Zhen-Xiang; Kim Sheene; Kulkarni Ameya; Distefano Alberto; Hwang Yu-Jin; Reznick Richard M; Codella Roberto; Zhang Dongyan; Cline Gary W; Wakil Salih J; Shulman Gerald I
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16480-5.
2007: Kim Ja-Young; van de Wall Esther; Laplante Mathieu; Azzara Anthony; Trujillo Maria E; Hofmann Susanna M; Schraw Todd; Durand Jorge L; Li Hua; Li Guangyu; Jelicks Linda A; Mehler Mark F; Hui David Y; Deshaies Yves; Shulman Gerald I; Schwartz Gary J; Scherer Philipp E
Obesity-associated improvements in metabolic profile through expansion of adipose tissue.
The Journal of clinical investigation 2007;117(9):2621-37.
2007: Farese Robert V; Sajan Mini P; Yang Hong; Li Pengfei; Mastorides Steven; Gower William R; Nimal Sonali; Choi Cheol Soo; Kim Sheene; Shulman Gerald I; Kahn C Ronald; Braun Ursula; Leitges Michael
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
The Journal of clinical investigation 2007;117(8):2289-301.
2007: Choi Cheol Soo; Savage David B; Kulkarni Ameya; Yu Xing Xian; Liu Zhen-Xiang; Morino Katsutaro; Kim Sheene; Distefano Alberto; Samuel Varman T; Neschen Susanne; Zhang Dongyan; Wang Amy; Zhang Xian-Man; Kahn Mario; Cline Gary W; Pandey Sanjay K; Geisler John G; Bhanot Sanjay; Monia Brett P; Shulman Gerald I
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
The Journal of biological chemistry 2007;282(31):22678-88.
2007: Petersen Kitt Falk; Dufour Sylvie; Savage David B; Bilz Stefan; Solomon Gina; Yonemitsu Shin; Cline Gary W; Befroy Douglas; Zemany Laura; Kahn Barbara B; Papademetris Xenophon; Rothman Douglas L; Shulman Gerald I
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12587-94.
2007: Choi Cheol Soo; Fillmore Jonathan J; Kim Jason K; Liu Zhen-Xiang; Kim Sheene; Collier Emily F; Kulkarni Ameya; Distefano Alberto; Hwang Yu-Jin; Kahn Mario; Chen Yan; Yu Chunli; Moore Irene K; Reznick Richard M; Higashimori Takamasa; Shulman Gerald I
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.
The Journal of clinical investigation 2007;117(7):1995-2003.
2007: Tong Qingchun; Ye ChianPing; McCrimmon Rory J; Dhillon Harveen; Choi Brian; Kramer Melissa D; Yu Jia; Yang Zongfang; Christiansen Lauryn M; Lee Charlotte E; Choi Cheol Soo; Zigman Jeffrey M; Shulman Gerald I; Sherwin Robert S; Elmquist Joel K; Lowell Bradford B
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
Cell metabolism 2007;5(5):383-93.
2007: Nagle Cynthia A; An Jie; Shiota Masakazu; Torres Tracy P; Cline Gary W; Liu Zhen-Xiang; Wang Shuli; Catlin Reetta L; Shulman Gerald I; Newgard Christopher B; Coleman Rosalind A
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.
The Journal of biological chemistry 2007;282(20):14807-15.
2007: Befroy Douglas E; Petersen Kitt Falk; Dufour Sylvie; Mason Graeme F; de Graaf Robin A; Rothman Douglas L; Shulman Gerald I
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients.
Diabetes 2007;56(5):1376-81.
2007: Savage David B; Petersen Kitt Falk; Shulman Gerald I
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Physiological reviews 2007;87(2):507-20.
2007: Kibbey Richard G; Pongratz Rebecca L; Romanelli Anthony J; Wollheim Claes B; Cline Gary W; Shulman Gerald I
Mitochondrial GTP regulates glucose-stimulated insulin secretion.
Cell metabolism 2007;5(4):253-64.
2007: Neschen Susanne; Morino Katsutaro; Dong Jianying; Wang-Fischer Yanlin; Cline Gary W; Romanelli Anthony J; Rossbacher Jörg C; Moore Irene K; Regittnig Werner; Munoz David S; Kim Jung H; Shulman Gerald I
n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.
Diabetes 2007;56(4):1034-41.
2007: Hurov Jonathan B; Huang Mei; White Lynn S; Lennerz Jochen; Choi Cheol Soo; Cho You-Ree; Kim Hyo-Jeong; Prior Julie L; Piwnica-Worms David; Cantley Lewis C; Kim Jason K; Shulman Gerald I; Piwnica-Worms Helen
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5680-5.
2007: Samuel Varman T; Liu Zhen-Xiang; Wang Amy; Beddow Sara A; Geisler John G; Kahn Mario; Zhang Xian-man; Monia Brett P; Bhanot Sanjay; Shulman Gerald I
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.
The Journal of clinical investigation 2007;117(3):739-45.
2007: Reznick Richard M; Zong Haihong; Li Ji; Morino Katsutaro; Moore Irene K; Yu Hannah J; Liu Zhen-Xiang; Dong Jianying; Mustard Kirsty J; Hawley Simon A; Befroy Douglas; Pypaert Marc; Hardie D Grahame; Young Lawrence H; Shulman Gerald I
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.
Cell metabolism 2007;5(2):151-6.
2007: Gao Qian; Mezei Gabor; Nie Yongzhan; Rao Yan; Choi Cheol Soo; Bechmann Ingo; Leranth Csaba; Toran-Allerand Dominique; Priest Catherine A; Roberts James L; Gao Xiao-Bing; Mobbs Charles; Shulman Gerald I; Diano Sabrina; Horvath Tamas L
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals.
Nature medicine 2007;13(1):89-94.
2007: Pongratz Rebecca L; Kibbey Richard G; Shulman Gerald I; Cline Gary W
Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.
The Journal of biological chemistry 2007;282(1):200-7.
2007: Mason Graeme F; Petersen Kitt Falk; de Graaf Robin A; Shulman Gerald I; Rothman Douglas L
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose.
Journal of neurochemistry 2007;100(1):73-86.
2007: Liska David; Dufour Sylvie; Zern Tosca L; Taksali Sara; Calí Anna M G; Dziura James; Shulman Gerald I; Pierpont Bridget M; Caprio Sonia
Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents.
PloS one 2007;2(6):e569.
2006: Vianna Claudia R; Huntgeburth Michael; Coppari Roberto; Choi Cheol Soo; Lin Jiandie; Krauss Stefan; Barbatelli Giorgio; Tzameli Iphigenia; Kim Young-Bum; Cinti Saverio; Shulman Gerald I; Spiegelman Bruce M; Lowell Bradford B
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Cell metabolism 2006;4(6):453-64.
2006: Morino Katsutaro; Petersen Kitt Falk; Shulman Gerald I
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction.
Diabetes 2006;55 Suppl 2():S9-S15.
2006: Petersen Kitt Falk; Dufour Sylvie; Feng Jing; Befroy Douglas; Dziura James; Dalla Man Chiara; Cobelli Claudio; Shulman Gerald I
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18273-7.
2006: Chen Alon; Brar Bhawanjit; Choi Cheol Soo; Rousso David; Vaughan Joan; Kuperman Yael; Kim Shee Ne; Donaldson Cindy; Smith Sean M; Jamieson Pauline; Li Chien; Nagy Tim R; Shulman Gerald I; Lee Kuo-Fen; Vale Wylie
Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16580-5.
2006: Sørensen Heidi; Brand Christian L; Neschen Susanne; Holst Jens Juul; Fosgerau Keld; Nishimura Erica; Shulman Gerald I
Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.
Diabetes 2006;55(10):2843-8.
2006: Park So-Young; Cho You-Ree; Kim Hyo-Jeong; Hong Eun-Gyoung; Higashimori Takamasa; Lee Sang Jun; Goldberg Ira J; Shulman Gerald I; Najjar Sonia M; Kim Jason K
Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E517-24.
2006: Wu J Julie; Roth Rachel J; Anderson Ethan J; Hong Eun-Gyoung; Lee Mi-Kyung; Choi Cheol Soo; Neufer P Darrell; Shulman Gerald I; Kim Jason K; Bennett Anton M
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.
Cell metabolism 2006;4(1):61-73.
2006: Samuel Varman T; Choi Cheol Soo; Phillips Trevor G; Romanelli Anthony J; Geisler John G; Bhanot Sanjay; McKay Robert; Monia Brett; Shutter John R; Lindberg Richard A; Shulman Gerald I; Veniant Murielle M
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.
Diabetes 2006;55(7):2042-50.
2006: Cao Haiming; Maeda Kazuhisa; Gorgun Cem Z; Kim Hyo-Jeong; Park So-Young; Shulman Gerald I; Kim Jason K; Hotamisligil Gökhan S
Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.
Diabetes 2006;55(7):1915-22.
2006: Reznick Richard M; Shulman Gerald I
The role of AMP-activated protein kinase in mitochondrial biogenesis.
The Journal of physiology 2006;574(Pt 1):33-9.
2006: Dubois Marie-Julie; Bergeron Sébastien; Kim Hyo-Jeong; Dombrowski Luce; Perreault Mylène; Fournès Bénédicte; Faure Robert; Olivier Martin; Beauchemin Nicole; Shulman Gerald I; Siminovitch Katherine A; Kim Jason K; Marette André
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Nature medicine 2006;12(5):549-56.
2006: Petersen Kitt Falk; Shulman Gerald I
Etiology of insulin resistance.
The American journal of medicine 2006;119(5 Suppl 1):S10-6.
2006: Hertzel Ann V; Smith Lisa Ann; Berg Anders H; Cline Gary W; Shulman Gerald I; Scherer Philipp E; Bernlohr David A
Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E814-23.
2006: Mason Graeme F; Petersen Kitt F; Lebon Vincent; Rothman Douglas L; Shulman Gerald I
Increased brain monocarboxylic acid transport and utilization in type 1 diabetes.
Diabetes 2006;55(4):929-34.
2006: Neschen Susanne; Morino Katsutaro; Rossbacher Jörg C; Pongratz Rebecca L; Cline Gary W; Sono Saki; Gillum Matthew; Shulman Gerald I
Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.
Diabetes 2006;55(4):924-8.
2006: Bilz Stefan; Samuel Varman; Morino Katsutaro; Savage David; Choi Cheol Soo; Shulman Gerald I
Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E716-22.
2006: Savage David B; Choi Cheol Soo; Samuel Varman T; Liu Zhen-Xiang; Zhang Dongyan; Wang Amy; Zhang Xian-Man; Cline Gary W; Yu Xing Xian; Geisler John G; Bhanot Sanjay; Monia Brett P; Shulman Gerald I
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
The Journal of clinical investigation 2006;116(3):817-24.
2006: Petersen Kitt Falk; Shulman Gerald I
New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy.
Obesity (Silver Spring, Md.) 2006;14 Suppl 1():34S-40S.
2005: Morino Katsutaro; Petersen Kitt Falk; Dufour Sylvie; Befroy Douglas; Frattini Jared; Shatzkes Nadine; Neschen Susanne; White Morris F; Bilz Stefan; Sono Saki; Pypaert Marc; Shulman Gerald I
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
The Journal of clinical investigation 2005;115(12):3587-93.
2005: Bajaj Mandeep; Suraamornkul Swangjit; Romanelli Anthony; Cline Gary W; Mandarino Lawrence J; Shulman Gerald I; DeFronzo Ralph A
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes 2005;54(11):3148-53.
2005: Bernroider Elisabeth; Brehm Attila; Krssak Martin; Anderwald Christian; Trajanoski Zlatko; Cline Gary; Shulman Gerald I; Roden Michael
The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(10):5559-65.
2005: Petersen Kitt F; Dufour Sylvie; Shulman Gerald I
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.
PLoS medicine 2005;2(9):e233.
2005: Neschen Susanne; Morino Katsutaro; Hammond Linda E; Zhang Dongyan; Liu Zhen-Xiang; Romanelli Anthony J; Cline Gary W; Pongratz Rebecca L; Zhang Xian-Man; Choi Cheol S; Coleman Rosalind A; Shulman Gerald I
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
Cell metabolism 2005;2(1):55-65.
2005: Hammond Linda E; Neschen Susanne; Romanelli Anthony J; Cline Gary W; Ilkayeva Olga R; Shulman Gerald I; Muoio Deborah M; Coleman Rosalind A
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
The Journal of biological chemistry 2005;280(27):25629-36.
2005: Park So-Young; Kim Hyo-Jeong; Wang Shupei; Higashimori Takamasa; Dong Jianying; Kim Yoon-Jung; Cline Gary; Li Hong; Prentki Marc; Shulman Gerald I; Mitchell Grant A; Kim Jason K
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.
American journal of physiology. Endocrinology and metabolism 2005;289(1):E30-9.
2005: Kim Jason K; Kim Hyo-Jeong; Park So-Young; Cederberg Anna; Westergren Rickard; Nilsson Daniel; Higashimori Takamasa; Cho You-Ree; Liu Zhen-Xiang; Dong Jianying; Cline Gary W; Enerback Sven; Shulman Gerald I
Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance.
Diabetes 2005;54(6):1657-63.
2005: Weiss Ram; Taksali Sara E; Dufour Sylvie; Yeckel Catherine W; Papademetris Xenophon; Cline Gary; Tamborlane William V; Dziura James; Shulman Gerald I; Caprio Sonia
The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning.
The Journal of clinical endocrinology and metabolism 2005;90(6):3731-7.
2005: Savage David B; Petersen Kitt F; Shulman Gerald I
Mechanisms of insulin resistance in humans and possible links with inflammation.
Hypertension 2005;45(5):828-33.
2005: Petersen Kitt Falk; Dufour Sylvie; Befroy Douglas; Lehrke Michael; Hendler Rosa E; Shulman Gerald I
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes.
Diabetes 2005;54(3):603-8.
2005: Kernan Walter N; Viscoli Catherine M; Inzucchi Silvio E; Brass Lawrence M; Bravata Dawn M; Shulman Gerald I; McVeety James C
Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke.
Archives of internal medicine 2005;165(2):227-33.
2005: Lowell Bradford B; Shulman Gerald I
Mitochondrial dysfunction and type 2 diabetes.
Science (New York, N.Y.) 2005;307(5708):384-7.
2004: Krssak Martin; Brehm Attila; Bernroider Elisabeth; Anderwald Christian; Nowotny Peter; Dalla Man Chiara; Cobelli Claudio; Cline Gary W; Shulman Gerald I; Waldhäusl Werner; Roden Michael
Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.
Diabetes 2004;53(12):3048-56.
2004: Wilson Frederick H; Hariri Ali; Farhi Anita; Zhao Hongyu; Petersen Kitt Falk; Toka Hakan R; Nelson-Williams Carol; Raja Khalid M; Kashgarian Michael; Shulman Gerald I; Scheinman Steven J; Lifton Richard P
A cluster of metabolic defects caused by mutation in a mitochondrial tRNA.
Science (New York, N.Y.) 2004;306(5699):1190-4.
2004: Lin Jiandie; Wu Pei-Hsuan; Tarr Paul T; Lindenberg Katrin S; St-Pierre Julie; Zhang Chen-Yu; Mootha Vamsi K; Jäger Sibylle; Vianna Claudia R; Reznick Richard M; Cui Libin; Manieri Monia; Donovan Mi X; Wu Zhidan; Cooper Marcus P; Fan Melina C; Rohas Lindsay M; Zavacki Ann Marie; Cinti Saverio; Shulman Gerald I; Lowell Bradford B; Krainc Dimitri; Spiegelman Bruce M
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell 2004;119(1):121-35.
2004: Cline Gary W; Lepine Rebecca L; Papas Klearchos K; Kibbey Richard G; Shulman Gerald I
13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.
The Journal of biological chemistry 2004;279(43):44370-5.
2004: Kim Jason K; Fillmore Jonathan J; Sunshine Mary Jean; Albrecht Bjoern; Higashimori Takamasa; Kim Dong-Wook; Liu Zhen-Xiang; Soos Timothy J; Cline Gary W; O'Brien William R; Littman Dan R; Shulman Gerald I
PKC-theta knockout mice are protected from fat-induced insulin resistance.
The Journal of clinical investigation 2004;114(6):823-7.
2004: Shulman Gerald I
Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy.
Physiology (Bethesda, Md.) 2004;19():183-90.
2004: Samuel Varman T; Liu Zhen-Xiang; Qu Xianqin; Elder Benjamin D; Bilz Stefan; Befroy Douglas; Romanelli Anthony J; Shulman Gerald I
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.
The Journal of biological chemistry 2004;279(31):32345-53.
2004: Zabolotny Janice M; Haj Fawaz G; Kim Young-Bum; Kim Hyo-Jeong; Shulman Gerald I; Kim Jason K; Neel Benjamin G; Kahn Barbara B
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
The Journal of biological chemistry 2004;279(23):24844-51.
2004: Shen Qi; Cline Gary W; Shulman Gerald I; Leibowitz Mark D; Davies Peter J A
Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.
The Journal of biological chemistry 2004;279(19):19721-31.
2004: Gao Qian; Wolfgang Michael J; Neschen Susanne; Morino Katsutaro; Horvath Tamas L; Shulman Gerald I; Fu Xin-Yuan
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4661-6.
2004: Kim Jason K; Gimeno Ruth E; Higashimori Takamasa; Kim Hyo-Jeong; Choi Hyejeong; Punreddy Sandhya; Mozell Robin L; Tan Guo; Stricker-Krongrad Alain; Hirsch David J; Fillmore Jonathan J; Liu Zhen-Xiang; Dong Jianying; Cline Gary; Stahl Andreas; Lodish Harvey F; Shulman Gerald I
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle.
The Journal of clinical investigation 2004;113(5):756-63.
2004: An Jie; Muoio Deborah M; Shiota Masakazu; Fujimoto Yuka; Cline Gary W; Shulman Gerald I; Koves Timothy R; Stevens Robert; Millington David; Newgard Christopher B
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
Nature medicine 2004;10(3):268-74.
2004: Petersen Kitt Falk; Dufour Sylvie; Befroy Douglas; Garcia Rina; Shulman Gerald I
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.
The New England journal of medicine 2004;350(7):664-71.
2004: Erol Erdal; Kumar Leena S; Cline Gary W; Shulman Gerald I; Kelly Daniel P; Binas Bert
Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):347-9.
2003: Goforth Harold W; Laurent Didier; Prusaczyk William K; Schneider Kevin E; Petersen Kitt Falk; Shulman Gerald I
Effects of depletion exercise and light training on muscle glycogen supercompensation in men.
American journal of physiology. Endocrinology and metabolism 2003;285(6):E1304-11.
2003: Rangwala Shamina M; Rhoades Ben; Shapiro Jennifer S; Rich A Sophie; Kim Jason K; Shulman Gerald I; Kaestner Klaus H; Lazar Mitchell A
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
Developmental cell 2003;5(4):657-63.
2003: Weiss Ram; Dufour Sylvie; Taksali Sara E; Tamborlane William V; Petersen Kitt F; Bonadonna Riccardo C; Boselli Linda; Barbetta Gina; Allen Karin; Rife Francis; Savoye Mary; Dziura James; Sherwin Robert; Shulman Gerald I; Caprio Sonia
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning.
Lancet 2003;362(9388):951-7.
2003: Coven David L; Hu Xiaoyue; Cong Lin; Bergeron Raynald; Shulman Gerald I; Hardie D Grahame; Young Lawrence H
Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E629-36.
2003: Spurlin Beth A; Thomas Rhonda M; Nevins Angela K; Kim Hyo-Jeong; Kim Yoon-Jung; Noh Hye-Lim; Shulman Gerald I; Kim Jason K; Thurmond Debbie C
Insulin resistance in tetracycline-repressible Munc18c transgenic mice.
Diabetes 2003;52(8):1910-7.
2003: Wenk Markus R; Lucast Louise; Di Paolo Gilbert; Romanelli Anthony J; Suchy Sharon F; Nussbaum Robert L; Cline Gary W; Shulman Gerald I; McMurray Walter; De Camilli Pietro
Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry.
Nature biotechnology 2003;21(7):813-7.
2003: Kim Jason K; Fillmore Jonathan J; Gavrilova Oksana; Chao Lily; Higashimori Takamasa; Choi Hyejeong; Kim Hyo-Jeong; Yu Chunli; Chen Yan; Qu Xianqin; Haluzik Martin; Reitman Marc L; Shulman Gerald I
Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice.
Diabetes 2003;52(6):1311-8.
2003: Kernan Walter N; Inzucchi Silvio E; Viscoli Catherine M; Brass Lawrence M; Bravata Dawn M; Shulman Gerald I; McVeety James C; Horwitz Ralph I
Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke.
Stroke; a journal of cerebral circulation 2003;34(6):1431-6.
2003: Petersen Kitt Falk; Befroy Douglas; Dufour Sylvie; Dziura James; Ariyan Charlotte; Rothman Douglas L; DiPietro Loretta; Cline Gary W; Shulman Gerald I
Mitochondrial dysfunction in the elderly: possible role in insulin resistance.
Science (New York, N.Y.) 2003;300(5622):1140-2.
2003: Kernan W N; Inzucchi S E; Viscoli C M; Brass L M; Bravata D M; Shulman G I; McVeety J C; Horwitz R I
Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke.
Neurology 2003;60(9):1447-51.
2003: Enoksson Staffan; Caprio Sonia K; Rife Frances; Shulman Gerald I; Tamborlane William V; Sherwin Robert S
Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia.
The Journal of clinical endocrinology and metabolism 2003;88(4):1503-11.
2003: Hulver Matthew W; Berggren Jason R; Cortright Ronald N; Dudek Ronald W; Thompson R Peter; Pories Walter J; MacDonald Kenneth G; Cline Gary W; Shulman Gerald I; Dohm G Lynis; Houmard Joseph A
Skeletal muscle lipid metabolism with obesity.
American journal of physiology. Endocrinology and metabolism 2003;284(4):E741-7.
2003: Borg Monica A; Tamborlane William V; Shulman Gerald I; Sherwin Robert S
Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation.
Diabetes 2003;52(3):663-6.
2003: Mason Graeme F; Falk Petersen Kitt; de Graaf Robin A; Kanamatsu Tomoyuki; Otsuki Taisuke; Shulman Gerald I; Rothman Douglas L
A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose.
Brain research. Brain research protocols 2003;10(3):181-90.
2002: Zong Haihong; Ren Jian Ming; Young Lawrence H; Pypaert Marc; Mu James; Birnbaum Morris J; Shulman Gerald I
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15983-7.
2002: Yu Chunli; Chen Yan; Cline Gary W; Zhang Dongyan; Zong Haihong; Wang Yanlin; Bergeron Raynald; Kim Jason K; Cushman Samuel W; Cooney Gregory J; Atcheson Bronwyn; White Morris F; Kraegen Edward W; Shulman Gerald I
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
The Journal of biological chemistry 2002;277(52):50230-6.
2002: McCrimmon R J; Evans M L; Jacob R J; Fan X; Zhu Y; Shulman G I; Sherwin R S
AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.
American journal of physiology. Endocrinology and metabolism 2002;283(5):E1076-83.
2002: Houmard Joseph A; Tanner Charles J; Yu Chunli; Cunningham Paul G; Pories Walter J; MacDonald Kenneth G; Shulman Gerald I
Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.
Diabetes 2002;51(10):2959-63.
2002: Cline Gary W; Johnson Kirk; Regittnig Werner; Perret Pascale; Tozzo Effie; Xiao Linda; Damico Christine; Shulman Gerald I
Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.
Diabetes 2002;51(10):2903-10.
2002: Petersen Kitt F; Shulman Gerald I
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus.
The American journal of cardiology 2002;90(5A):11G-18G.
2002: Inzucchi Silvio E; Petersen Kitt F; Shulman Gerald I
Nonalcoholic fatty liver disease.
The New England journal of medicine 2002;347(10):768-9; author reply 768-9.
2002: Kim Young-Bum; Shulman Gerald I; Kahn Barbara B
Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.
The Journal of biological chemistry 2002;277(36):32915-22.
2002: Pan Jullie W; de Graaf Robin A; Petersen Kitt F; Shulman Gerald I; Hetherington Hoby P; Rothman Douglas L
[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(7):890-8.
2002: Haluzik Martin; Dietz Kelly R; Kim Jason K; Marcus-Samuels Bernice; Shulman Gerald I; Gavrilova Oksana; Reitman Marc L
Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity.
Diabetes 2002;51(7):2113-8.
2002: Petersen Kitt Falk; Oral Elif Arioglu; Dufour Sylvie; Befroy Douglas; Ariyan Charlotte; Yu Chunli; Cline Gary W; DePaoli Alex M; Taylor Simeon I; Gorden Phillip; Shulman Gerald I
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.
The Journal of clinical investigation 2002;109(10):1345-50.
2002: Hundal Ripudaman S; Petersen Kitt F; Mayerson Adam B; Randhawa Pritpal S; Inzucchi Silvio; Shoelson Steven E; Shulman Gerald I
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
The Journal of clinical investigation 2002;109(10):1321-6.
2002: Sinha Ranjana; Dufour Sylvie; Petersen Kitt Falk; LeBon Vincent; Enoksson Staffan; Ma Yong-Zhan; Savoye Mary; Rothman Douglas L; Shulman Gerald I; Caprio Sonia
Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity.
Diabetes 2002;51(4):1022-7.
2002: Lebon Vincent; Petersen Kitt F; Cline Gary W; Shen Jun; Mason Graeme F; Dufour Sylvie; Behar Kevin L; Shulman Gerald I; Rothman Douglas L
Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1523-31.
2002: Mayerson Adam B; Hundal Ripudaman S; Dufour Sylvie; Lebon Vincent; Befroy Douglas; Cline Gary W; Enocksson Staffan; Inzucchi Silvio E; Shulman Gerald I; Petersen Kitt F
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes.
Diabetes 2002;51(3):797-802.
2002: Shiota Masakazu; Moore Mary Courtney; Galassetti Pietro; Monohan Michael; Neal Doss W; Shulman Gerald I; Cherrington Alan D
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
Diabetes 2002;51(2):469-78.
2002: Neschen Susanne; Moore Irene; Regittnig Werner; Yu Chun Li; Wang Yanlin; Pypaert Marc; Petersen Kitt Falk; Shulman Gerald I
Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.
American journal of physiology. Endocrinology and metabolism 2002;282(2):E395-401.
2002: Bischof Martin G; Bernroider Elisabeth; Krssak Martin; Krebs Michael; Stingl Harald; Nowotny Peter; Yu Chunlin; Shulman Gerald I; Waldhäusl Werner; Roden Michael
Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia.
Diabetes 2002;51(1):49-54.
2002: Petersen Kitt Falk; Shulman Gerald I
Cellular mechanism of insulin resistance in skeletal muscle.
Journal of the Royal Society of Medicine 2002;95 Suppl 42():8-13.
2001: Bergeron R; Ren J M; Cadman K S; Moore I K; Perret P; Pypaert M; Young L H; Semenkovich C F; Shulman G I
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1340-6.
2001: Lebon V; Dufour S; Petersen K F; Ren J; Jucker B M; Slezak L A; Cline G W; Rothman D L; Shulman G I
Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle.
The Journal of clinical investigation 2001;108(5):733-7.
2001: Kim J K; Kim Y J; Fillmore J J; Chen Y; Moore I; Lee J; Yuan M; Li Z W; Karin M; Perret P; Shoelson S E; Shulman G I
Prevention of fat-induced insulin resistance by salicylate.
The Journal of clinical investigation 2001;108(3):437-46.
2001: Kim J K; Zisman A; Fillmore J J; Peroni O D; Kotani K; Perret P; Zong H; Dong J; Kahn C R; Kahn B B; Shulman G I
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
The Journal of clinical investigation 2001;108(1):153-60.
2001: Zhang C Y; Baffy G; Perret P; Krauss S; Peroni O; Grujic D; Hagen T; Vidal-Puig A J; Boss O; Kim Y B; Zheng X X; Wheeler M B; Shulman G I; Chan C B; Lowell B B
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Cell 2001;105(6):745-55.
2001: Kim J K; Fillmore J J; Chen Y; Yu C; Moore I K; Pypaert M; Lutz E P; Kako Y; Velez-Carrasco W; Goldberg I J; Breslow J L; Shulman G I
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7522-7.
2001: Cho H; Mu J; Kim J K; Thorvaldsen J L; Chu Q; Crenshaw E B; Kaestner K H; Bartolomei M S; Shulman G I; Birnbaum M J
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
Science (New York, N.Y.) 2001;292(5522):1728-31.
2001: Petersen K F; Laurent D; Yu C; Cline G W; Shulman G I
Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans.
Diabetes 2001;50(6):1263-8.
2001: Cline G W; Vidal-Puig A J; Dufour S; Cadman K S; Lowell B B; Shulman G I
In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism.
The Journal of biological chemistry 2001;276(23):20240-4.
2001: Yang C; Coker K J; Kim J K; Mora S; Thurmond D C; Davis A C; Yang B; Williamson R A; Shulman G I; Pessin J E
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.
The Journal of clinical investigation 2001;107(10):1311-8.
2001: Bergeron R; Previs S F; Cline G W; Perret P; Russell R R; Young L H; Shulman G I
Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.
Diabetes 2001;50(5):1076-82.
2001: Petersen K F; Cline G W; Gerard D P; Magnusson I; Rothman D L; Shulman G I
Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans.
Metabolism: clinical and experimental 2001;50(5):598-601.
2001: Zabolotny J M; Kim Y B; Peroni O D; Kim J K; Pani M A; Boss O; Klaman L D; Kamatkar S; Shulman G I; Kahn B B; Neel B G
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5187-92.
2001: Abel E D; Peroni O; Kim J K; Kim Y B; Boss O; Hadro E; Minnemann T; Shulman G I; Kahn B B
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Nature 2001;409(6821):729-33.
2001: Stingl H; Krssák M; Krebs M; Bischof M G; Nowotny P; Fürnsinn C; Shulman G I; Waldhäusl W; Roden M
Lipid-dependent control of hepatic glycogen stores in healthy humans.
Diabetologia 2001;44(1):48-54.
2001: Rui L; Aguirre V; Kim J K; Shulman G I; Lee A; Corbould A; Dunaif A; White M F
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
The Journal of clinical investigation 2001;107(2):181-9.
2001: Roden M; Petersen K F; Shulman G I
Nuclear magnetic resonance studies of hepatic glucose metabolism in humans.
Recent progress in hormone research 2001;56():219-37.
2000: Hundal R S; Krssak M; Dufour S; Laurent D; Lebon V; Chandramouli V; Inzucchi S E; Schumann W C; Petersen K F; Landau B R; Shulman G I
Mechanism by which metformin reduces glucose production in type 2 diabetes.
Diabetes 2000;49(12):2063-9.
2000: Jucker B M; Ren J; Dufour S; Cao X; Previs S F; Cadman K S; Shulman G I
13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression.
The Journal of biological chemistry 2000;275(50):39279-86.
2000: Previs S F; Withers D J; Ren J M; White M F; Shulman G I
Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.
The Journal of biological chemistry 2000;275(50):38990-4.
2000: Klaman L D; Boss O; Peroni O D; Kim J K; Martino J L; Zabolotny J M; Moghal N; Lubkin M; Kim Y B; Sharpe A H; Stricker-Krongrad A; Shulman G I; Neel B G; Kahn B B
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Molecular and cellular biology 2000;20(15):5479-89.
2000: Michael M D; Kulkarni R N; Postic C; Previs S F; Shulman G I; Magnuson M A; Kahn C R
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Molecular cell 2000;6(1):87-97.
2000: Shulman G I
Cellular mechanisms of insulin resistance.
The Journal of clinical investigation 2000;106(2):171-6.
2000: McNulty P H; Cline G W; Whiting J M; Shulman G I
Regulation of myocardial [(13)C]glucose metabolism in conscious rats.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H375-81.
2000: Kim J K; Michael M D; Previs S F; Peroni O D; Mauvais-Jarvis F; Neschen S; Kahn B B; Kahn C R; Shulman G I
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
The Journal of clinical investigation 2000;105(12):1791-7.
2000: Laurent D; Schneider K E; Prusaczyk W K; Franklin C; Vogel S M; Krssak M; Petersen K F; Goforth H W; Shulman G I
Effects of caffeine on muscle glycogen utilization and the neuroendocrine axis during exercise.
The Journal of clinical endocrinology and metabolism 2000;85(6):2170-5.
2000: Jucker B M; Dufour S; Ren J; Cao X; Previs S F; Underhill B; Cadman K S; Shulman G I
Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6880-4.
2000: Petersen K F; Krssak M; Inzucchi S; Cline G W; Dufour S; Shulman G I
Mechanism of troglitazone action in type 2 diabetes.
Diabetes 2000;49(5):827-31.
2000: Roden M; Stingl H; Chandramouli V; Schumann W C; Hofer A; Landau B R; Nowotny P; Waldhäusl W; Shulman G I
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.
Diabetes 2000;49(5):701-7.
2000: Laurent D; Hundal R S; Dresner A; Price T B; Vogel S M; Petersen K F; Shulman G I
Mechanism of muscle glycogen autoregulation in humans.
American journal of physiology. Endocrinology and metabolism 2000;278(4):E663-8.
2000: Ren J M; Barucci N; Marshall B A; Hansen P; Mueckler M M; Shulman G I
Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise.
American journal of physiology. Endocrinology and metabolism 2000;278(4):E588-92.
2000: Kim J K; Gavrilova O; Chen Y; Reitman M L; Shulman G I
Mechanism of insulin resistance in A-ZIP/F-1 fatless mice.
The Journal of biological chemistry 2000;275(12):8456-60.
2000: McNulty P H; Jagasia D; Cline G W; Ng C K; Whiting J M; Garg P; Shulman G I; Soufer R
Persistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion.
Circulation 2000;101(8):917-22.
2000: Krssak M; Petersen K F; Bergeron R; Price T; Laurent D; Rothman D L; Roden M; Shulman G I
Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study.
The Journal of clinical endocrinology and metabolism 2000;85(2):748-54.
2000: Gavrilova O; Marcus-Samuels B; Graham D; Kim J K; Shulman G I; Castle A L; Vinson C; Eckhaus M; Reitman M L
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.
The Journal of clinical investigation 2000;105(3):271-8.
2000: Price T B; Laurent D; Petersen K F; Rothman D L; Shulman G I
Glycogen loading alters muscle glycogen resynthesis after exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(2):698-704.
2000: Nagashima K; Cline G W; Mack G W; Shulman G I; Nadel E R
Intense exercise stimulates albumin synthesis in the upright posture.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(1):41-6.
1999: Jucker B M; Barucci N; Shulman G I
Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle.
The American journal of physiology 1999;277(3 Pt 1):E505-12.
1999: Russell R R; Bergeron R; Shulman G I; Young L H
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.
The American journal of physiology 1999;277(2 Pt 2):H643-9.
1999: Shulman G I
Cellular mechanisms of insulin resistance in humans.
The American journal of cardiology 1999;84(1A):3J-10J.
1999: Cline G W; Petersen K F; Krssak M; Shen J; Hundal R S; Trajanoski Z; Inzucchi S; Dresner A; Rothman D L; Shulman G I
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes.
The New England journal of medicine 1999;341(4):240-6.
1999: Previs S F; Cline G W; Shulman G I
A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo.
The American journal of physiology 1999;277(1 Pt 1):E154-60.
1999: Young L H; Russell R R; Yin R; Caplan M J; Ren J; Bergeron R; Shulman G I; Sinusas A J
Regulation of myocardial glucose uptake and transport during ischemia and energetic stress.
The American journal of cardiology 1999;83(12A):25H-30H.
1999: Griffin M E; Marcucci M J; Cline G W; Bell K; Barucci N; Lee D; Goodyear L J; Kraegen E W; White M F; Shulman G I
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Diabetes 1999;48(6):1270-4.
1999: Bergeron R; Russell R R; Young L H; Ren J M; Marcucci M; Lee A; Shulman G I
Effect of AMPK activation on muscle glucose metabolism in conscious rats.
The American journal of physiology 1999;276(5 Pt 1):E938-44.
1999: Borg M A; Borg W P; Tamborlane W V; Brines M L; Shulman G I; Sherwin R S
Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.
Diabetes 1999;48(3):584-7.
1999: Petersen K F; Krssak M; Navarro V; Chandramouli V; Hundal R; Schumann W C; Landau B R; Shulman G I
Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis.
The American journal of physiology 1999;276(3 Pt 1):E529-35.
1999: Krssak M; Falk Petersen K; Dresner A; DiPietro L; Vogel S M; Rothman D L; Roden M; Shulman G I
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.
Diabetologia 1999;42(1):113-6.
1999: Dresner A; Laurent D; Marcucci M; Griffin M E; Dufour S; Cline G W; Slezak L A; Andersen D K; Hundal R S; Rothman D L; Petersen K F; Shulman G I
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
The Journal of clinical investigation 1999;103(2):253-9.
1999: Jucker B M; Cline G W; Barucci N; Shulman G I
Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study.
Diabetes 1999;48(1):134-40.
1999: Roden M; Shulman G I
Applications of NMR spectroscopy to study muscle glycogen metabolism in man.
Annual review of medicine 1999;50():277-90.
1998: Russell R R; Yin R; Caplan M J; Hu X; Ren J; Shulman G I; Sinusas A J; Young L H
Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo.
Circulation 1998;98(20):2180-6.
1998: Robinson C; Tamborlane W V; Maggs D G; Enoksson S; Sherwin R S; Silver D; Shulman G I; Caprio S
Effect of insulin on glycerol production in obese adolescents.
The American journal of physiology 1998;274(4 Pt 1):E737-43.
1998: Petersen K F; Hendler R; Price T; Perseghin G; Rothman D L; Held N; Amatruda J M; Shulman G I
13C/31P NMR studies on the mechanism of insulin resistance in obesity.
Diabetes 1998;47(3):381-6.
1998: Inzucchi S E; Maggs D G; Spollett G R; Page S L; Rife F S; Walton V; Shulman G I
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.
The New England journal of medicine 1998;338(13):867-72.
1998: Petersen K F; Laurent D; Rothman D L; Cline G W; Shulman G I
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.
The Journal of clinical investigation 1998;101(6):1203-9.
1998: Withers D J; Gutierrez J S; Towery H; Burks D J; Ren J M; Previs S; Zhang Y; Bernal D; Pons S; Shulman G I; Bonner-Weir S; White M F
Disruption of IRS-2 causes type 2 diabetes in mice.
Nature 1998;391(6670):900-4.
1998: Cline G W; Jucker B M; Trajanoski Z; Rennings A J; Shulman G I
A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo.
The American journal of physiology 1998;274(2 Pt 1):E381-9.
1998: Maggs D G; Buchanan T A; Burant C F; Cline G; Gumbiner B; Hsueh W A; Inzucchi S; Kelley D; Nolan J; Olefsky J M; Polonsky K S; Silver D; Valiquett T R; Shulman G I
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
Annals of internal medicine 1998;128(3):176-85.
1998: Laurent D; Petersen K F; Russell R R; Cline G W; Shulman G I
Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans.
The American journal of physiology 1998;274(1 Pt 1):E130-8.
1997: Petersen K F; Jacob R; West A B; Sherwin R S; Shulman G I
Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis.
The American journal of physiology 1997;273(6 Pt 1):E1189-93.
1997: Russell R R; Cline G W; Guthrie P H; Goodwin G W; Shulman G I; Taegtmeyer H
Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation.
The Journal of clinical investigation 1997;100(11):2892-9.
1997: Jucker B M; Rennings A J; Cline G W; Petersen K F; Shulman G I
In vivo NMR investigation of intramuscular glucose metabolism in conscious rats.
The American journal of physiology 1997;273(1 Pt 1):E139-48.
1997: Perseghin G; Ghosh S; Gerow K; Shulman G I
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.
Diabetes 1997;46(6):1001-9.
1997: Cline G W; Magnusson I; Rothman D L; Petersen K F; Laurent D; Shulman G I
Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1997;99(9):2219-24.
1997: Jucker B M; Rennings A J; Cline G W; Shulman G I
13C and 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat.
The Journal of biological chemistry 1997;272(16):10464-73.
1997: Young L H; Renfu Y; Russell R; Hu X; Caplan M; Ren J; Shulman G I; Sinusas A J
Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo.
Circulation 1997;95(2):415-22.
1997: Borg M A; Sherwin R S; Borg W P; Tamborlane W V; Shulman G I
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
The Journal of clinical investigation 1997;99(2):361-5.
1997: Jacob R J; Dziura J; Medwick M B; Leone P; Caprio S; During M; Shulman G I; Sherwin R S
The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus.
Diabetes 1997;46(1):150-2.
1996: Jacob R J; Dziura J; Morgen J P; Shulman G I; Sherwin R S
Time course of the defective alpha-cell response to hypoglycemia in diabetic BB rats.
Metabolism: clinical and experimental 1996;45(11):1422-6.
1996: Velho G; Petersen K F; Perseghin G; Hwang J H; Rothman D L; Pueyo M E; Cline G W; Froguel P; Shulman G I
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
The Journal of clinical investigation 1996;98(8):1755-61.
1996: Perseghin G; Price T B; Petersen K F; Roden M; Cline G W; Gerow K; Rothman D L; Shulman G I
Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects.
The New England journal of medicine 1996;335(18):1357-62.
1996: Petersen K F; West A B; Reuben A; Rothman D L; Shulman G I
Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy.
Hepatology (Baltimore, Md.) 1996;24(1):114-7.
1996: McNulty P H; Sinusas A J; Shi C Q; Dione D; Young L H; Cline G C; Shulman G I
Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia.
The Journal of clinical investigation 1996;98(1):62-9.
1996: Roden M; Price T B; Perseghin G; Petersen K F; Rothman D L; Cline G W; Shulman G I
Mechanism of free fatty acid-induced insulin resistance in humans.
The Journal of clinical investigation 1996;97(12):2859-65.
1996: Price T B; Perseghin G; Duleba A; Chen W; Chase J; Rothman D L; Shulman R G; Shulman G I
NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5329-34.
1996: Roden M; Perseghin G; Petersen K F; Hwang J H; Cline G W; Gerow K; Rothman D L; Shulman G I
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans.
The Journal of clinical investigation 1996;97(3):642-8.
1996: Petersen K F; Price T; Cline G W; Rothman D L; Shulman G I
Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period.
The American journal of physiology 1996;270(1 Pt 1):E186-91.
1996: Taylor R; Magnusson I; Rothman D L; Cline G W; Caumo A; Cobelli C; Shulman G I
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.
The Journal of clinical investigation 1996;97(1):126-32.
1995: Cline G W; Shulman G I
Mass and positional isotopomer analysis of glucose metabolism in periportal and pericentral hepatocytes.
The Journal of biological chemistry 1995;270(47):28062-7.
1995: Petersen K F; Blair J B; Shulman G I
Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver.
Metabolism: clinical and experimental 1995;44(11):1380-3.
1995: Zawalich W S; Zawalich K C; Kelley G G; Shulman G I
Islet phosphoinositide hydrolysis and insulin secretory responses from prediabetic fa/fa ZDF rats.
Biochemical and biophysical research communications 1995;209(3):974-80.
1995: Hwang J H; Perseghin G; Rothman D L; Cline G W; Magnusson I; Petersen K F; Shulman G I
Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study.
The Journal of clinical investigation 1995;95(2):783-7.
1995: Magnusson I; Rothman D L; Gerard D P; Katz L D; Shulman G I
Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration.
Diabetes 1995;44(2):185-9.
1995: Borg W P; Sherwin R S; During M J; Borg M A; Shulman G I
Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release.
Diabetes 1995;44(2):180-4.
1994: Cline G W; Rothman D L; Magnusson I; Katz L D; Shulman G I
13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1994;94(6):2369-76.
1994: Gruetter R; Novotny E J; Boulware S D; Mason G F; Rothman D L; Shulman G I; Prichard J W; Shulman R G
Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose.
Journal of neurochemistry 1994;63(4):1377-85.
1994: Petersen K F; Cline G W; Blair J B; Shulman G I
Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3'-5-triiodo-L-thyronine-treated rats.
The American journal of physiology 1994;267(2 Pt 1):E273-7.
1994: Price T B; Taylor R; Mason G F; Rothman D L; Shulman G I; Shulman R G
Turnover of human muscle glycogen with low-intensity exercise.
Medicine and science in sports and exercise 1994;26(8):983-91.
1994: Gruetter R; Magnusson I; Rothman D L; Avison M J; Shulman R G; Shulman G I
Validation of 13C NMR measurements of liver glycogen in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1994;31(6):583-8.
1994: Caprio S; Cline G; Boulware S; Permanente C; Shulman G I; Sherwin R S; Tamborlane W V
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels.
The American journal of physiology 1994;266(6 Pt 1):E885-91.
1994: Magnusson I; Rothman D L; Jucker B; Cline G W; Shulman R G; Shulman G I
Liver glycogen turnover in fed and fasted humans.
The American journal of physiology 1994;266(5 Pt 1):E796-803.
1994: Borg W P; During M J; Sherwin R S; Borg M A; Brines M L; Shulman G I
Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.
The Journal of clinical investigation 1994;93(4):1677-82.
1994: Bloch G; Chase J R; Meyer D B; Avison M J; Shulman G I; Shulman R G
In vivo regulation of rat muscle glycogen resynthesis after intense exercise.
The American journal of physiology 1994;266(1 Pt 1):E85-91.
1994: Price T B; Rothman D L; Taylor R; Avison M J; Shulman G I; Shulman R G
Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(1):104-11.
1993: Rossi G; Sherwin R S; Penzias A S; Lapaczewski P; Jacob R J; Shulman G I; Diamond M P
Temporal changes in insulin resistance and secretion in 24-h-fasted conscious pregnant rats.
The American journal of physiology 1993;265(6 Pt 1):E845-51.
1993: Powell A M; Sherwin R S; Shulman G I
Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits.
The Journal of clinical investigation 1993;92(6):2667-74.
1993: Rossi G; Lapaczewski P; Diamond M P; Jacob R J; Shulman G I; Sherwin R S
Inhibitory effect of pregnancy on counterregulatory hormone responses to hypoglycemia in awake rat.
Diabetes 1993;42(10):1440-5.
1993: Taylor R; Price T B; Katz L D; Shulman R G; Shulman G I
Direct measurement of change in muscle glycogen concentration after a mixed meal in normal subjects.
The American journal of physiology 1993;265(2 Pt 1):E224-9.
1993: Gruetter R; Novotny E J; Boulware S D; Rothman D L; Mason G F; Shulman G I; Tamborlane W V; Shulman R G
Non-invasive measurements of the cerebral steady-state glucose concentration and transport in humans by 13C nuclear magnetic resonance.
Advances in experimental medicine and biology 1993;331():35-40.
1993: Cline G W; Greenawalt K; Shulman G I
Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo.
Acta diabetologica 1993;30(2):70-2.
1992: Petroff O A; Novotny E J; Avison M; Rothman D L; Alger J R; Ogino T; Shulman G I; Prichard J W
Cerebral lactate turnover after electroshock: in vivo measurements by 1H/13C magnetic resonance spectroscopy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(6):1022-9.
1992: Shulman G I; Landau B R
Pathways of glycogen repletion.
Physiological reviews 1992;72(4):1019-35.
1992: Rothman D L; Novotny E J; Shulman G I; Howseman A M; Petroff O A; Mason G; Nixon T; Hanstock C C; Prichard J W; Shulman R G
1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9603-6.
1992: Magnusson I; Rothman D L; Katz L D; Shulman R G; Shulman G I
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.
The Journal of clinical investigation 1992;90(4):1323-7.
1992: Ganesan S; Calle R; Zawalich K; Greenawalt K; Zawalich W; Shulman G I; Rasmussen H
Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion.
The Journal of cell biology 1992;119(2):313-24.
1992: Gruetter R; Rothman D L; Novotny E J; Shulman G I; Prichard J W; Shulman R G
Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1992;27(1):183-8.
1992: Taylor R; Price T B; Rothman D L; Shulman R G; Shulman G I
Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1992;27(1):13-20.
1992: Jacob R J; Sherwin R S; Greenawalt K; Shulman G I
Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rats.
Diabetes 1992;41(6):691-7.
1992: Rothman D L; Shulman R G; Shulman G I
31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1992;89(4):1069-75.
1992: Gruetter R; Novotny E J; Boulware S D; Rothman D L; Mason G F; Shulman G I; Shulman R G; Tamborlane W V
Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1109-12.
1991: Rothman D L; Magnusson I; Katz L D; Shulman R G; Shulman G I
Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR.
Science (New York, N.Y.) 1991;254(5031):573-6.
1991: Bowen L; Stein P P; Stevenson R; Shulman G I
The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats.
Metabolism: clinical and experimental 1991;40(10):1025-30.
1991: Rothman D L; Howseman A M; Graham G D; Petroff O A; Lantos G; Fayad P B; Brass L M; Shulman G I; Shulman R G; Prichard J W
Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1991;21(2):302-7.
1991: Magnusson I; Shulman G I
Pathways of hepatic glycogen synthesis in humans.
Medicine and science in sports and exercise 1991;23(8):939-43.
1991: Shulman G I; DeFronzo R A; Rossetti L
Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion.
The American journal of physiology 1991;260(5 Pt 1):E731-5.
1991: Cline G W; Shulman G I
Quantitative analysis of the pathways of glycogen repletion in periportal and perivenous hepatocytes in vivo.
The Journal of biological chemistry 1991;266(7):4094-8.
1990: Shulman G I; Cline G; Schumann W C; Chandramouli V; Kumaran K; Landau B R
Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans.
The American journal of physiology 1990;259(3 Pt 1):E335-41.
1990: Shulman G I; Rothman D L; Jue T; Stein P; DeFronzo R A; Shulman R G
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.
The New England journal of medicine 1990;322(4):223-8.
1990: Zawalich W S; Zawalich K C; Shulman G I; Rossetti L
Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets.
Endocrinology 1990;126(1):253-60.
1989: Shulman G I; Rossetti L
Influence of the route of glucose administration on hepatic glycogen repletion.
The American journal of physiology 1989;257(5 Pt 1):E681-5.
1989: Rossetti L; Rothman D L; DeFronzo R A; Shulman G I
Effect of dietary protein on in vivo insulin action and liver glycogen repletion.
The American journal of physiology 1989;257(2 Pt 1):E212-9.
1989: Jue T; Rothman D L; Shulman G I; Tavitian B A; DeFronzo R A; Shulman R G
Direct observation of glycogen synthesis in human muscle with 13C NMR.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4489-91.
1988: Shulman G I; Rothman D L; Chung Y; Rossetti L; Petit W A; Barrett E J; Shulman R G
13C NMR studies of glycogen turnover in the perfused rat liver.
The Journal of biological chemistry 1988;263(11):5027-9.
1987: Rossetti L; Shulman G I; Zawalich W; DeFronzo R A
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.
The Journal of clinical investigation 1987;80(4):1037-44.
1987: Rossetti L; Shulman G I; Zawalich W S
Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding.
Diabetes 1987;36(10):1212-5.

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