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Gerald Shulman

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Chemicals & Drugs

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Naoki Kumashiro; Romy Kursawe; Sachin K Majumdar; Vara Prasad Manchem; Kitt F Petersen; Varman T Samuel; Daniel F Vatner; Toru Yoshimura; Dongyan Zhang; Xian-Man Zhang; Sanjay Bhanot; Jennifer L Cantley; Gary W Cline; Derek M Erion; Ioana Fat; Glenn S Gerhard; Fitsum Guebre-Egziabher; Mario Kahn; Gerald I Shulman
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
Raffay S Khan; P Christian Schulze; Gerald I Shulman; Shuiqing Yu; William S Blaner; Aalap Chokshi; Konstantinos Drosatos; Collette R Harris; Shunichi Homma; Li-Shin Huang; Hongfeng Jiang; Ira J Goldberg
Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy.
Maya E Kotas; Gerald I Shulman; Charles Annicelli; Gary W Cline; Matthew P Gillum; Michael J Jurczak; Ruslan Medzhitov
Role of caspase-1 in regulation of triglyceride metabolism.

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All Publications

2013: Naoki Kumashiro; Romy Kursawe; Sachin K Majumdar; Vara Prasad Manchem; Kitt F Petersen; Varman T Samuel; Daniel F Vatner; Toru Yoshimura; Dongyan Zhang; Xian-Man Zhang; Sanjay Bhanot; Jennifer L Cantley; Gary W Cline; Derek M Erion; Ioana Fat; Glenn S Gerhard; Fitsum Guebre-Egziabher; Mario Kahn; Gerald I Shulman
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats.
Hepatology (Baltimore, Md.) 2013;57(5):1763-72.
2013: Raffay S Khan; P Christian Schulze; Gerald I Shulman; Shuiqing Yu; William S Blaner; Aalap Chokshi; Konstantinos Drosatos; Collette R Harris; Shunichi Homma; Li-Shin Huang; Hongfeng Jiang; Ira J Goldberg
Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy.
Journal of cardiovascular pharmacology 2013;61(4):345-54.
2013: Maya E Kotas; Gerald I Shulman; Charles Annicelli; Gary W Cline; Matthew P Gillum; Michael J Jurczak; Ruslan Medzhitov
Role of caspase-1 in regulation of triglyceride metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(12):4810-5.
2013: João Paulo G Camporez; Carla R O Carvalho; Blas A Guigni; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Shoichi Kanda; Hui-Young Lee; Kitt Falk Petersen; Varman T Samuel; Gerald I Shulman
Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance.
Endocrinology 2013;154(3):1021-8.
2013: Romy Kursawe; Aiping Lin; Deepak Narayan; Bridget Pierpont; Melissa Shaw; Sonia Caprio; Samuel W Cushman; Ebe D'Adamo; Cosimo Giannini; Gerald I Shulman
Decreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia.
Diabetes 2013;62(3):837-44.
2013: Jennifer L Cantley; Gary W Cline; Fitsum Guebre-Egziabher; Blas A Guigni; Joseph Hankin; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Naoki Kumashiro; Vara Prasad Manchem; Robert C Murphy; Varman T Samuel; Julie Serr; Sanjay Bhanot; J Mark Brown; Joao Paulo G Camporez; Toru Yoshimura; Dongyan Zhang; Gerald I Shulman
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(5):1869-74.
2013: Derek M Erion; Matthew P Gillum; Jennifer J Hsiao; Mario Kahn; Vara Prasad Manchem; Kisha Mitchell; Susan F Murray; Yoshio Nagai; Violetta Popov; Sanjay Bhanot; Gary W Cline; Jianying Dong; Gerald I Shulman; Daniel Vatner; Shin Yonemitsu; Varman T Samuel
The role of the carbohydrate response element-binding protein in male fructose-fed rats.
Endocrinology 2013;154(1):36-44.
2012: John E Dominy; Jessica Feldman; Steven P Gygi; Mark P Jedrychowski; Michael J Jurczak; Yoonjin Lee; Raul Mostoslavsky; Kerry Pierce; Joao Paulo Camporez; Helen Chim; Clary B Clish; John M Denu; Hai-Bin Ruan; Gerald I Shulman; Xiaoyong Yang; Pere Puigserver
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Molecular cell 2012;48(6):900-13.
2012: Douglas E Befroy; Kitt Falk Petersen; Douglas L Rothman; Gerald I Shulman
³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism.
Diabetes 2012;61(11):2669-78.
2012: Clare Flannery; Rasmus Rabøl; Gerald I Shulman; Sylvie Dufour; Kitt Falk Petersen
Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly.
Diabetes 2012;61(11):2711-7.
2012: Whitney H Brown; Joao Paulo G Camporez; Benjamin F Cravatt; Sabrina Diano; Derek M Erion; Matthew P Gillum; Blas A Guigni; Jin Kwon Jeong; Mario Kahn; Hui-Young Lee; Varman T Samuel; Tiago C Alves; Xian-Man Zhang; Gerald I Shulman
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(37):14966-71.
2012: Xiaofeng Li; Dakai Liu; Varman T Samuel; Jufang Shan; Gerald I Shulman; Ju Bao; Woochul Chang; Ingyu Kim; Ho-Jin Lee; Xinxin Zhang; Jie J Zheng; Dianqing Wu
Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(28):11402-7.
2012: Sandra Kleiner; Dina Laznik; Rina J Mepani; Gerald I Shulman; Diti Chatterjee Bhowmick; Jennifer L Estall; François R Jornayvaz; Michael J Jurczak; Li Ye; Bruce M Spiegelman
Development of insulin resistance in mice lacking PGC-1α in adipose tissues.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(24):9635-40.
2012: Zheng Sun; Carole Sztalryd; Terry G Unterman; Hong Wang; Dongyan Zhang; Rexford S Ahima; Michael J Bennett; Morris J Birnbaum; Jie Chen; Ravindra Dhir; Mark J Graham; Russell A Miller; Rajesh T Patel; Gerald I Shulman; Mitchell A Lazar
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.
Nature medicine 2012;18(6):934-42.
2012: Kitt Falk Petersen; Gary W Cline; Sylvie Dufour; Katsutaro Morino; Peter S Yoo; Gerald I Shulman
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(21):8236-40.
2012: François R Jornayvaz; Gerald I Shulman
Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance.
Cell metabolism 2012;15(5):574-84.
2012: Katsutaro Morino; Kitt Falk Petersen; Varman T Samuel; Cheol Soo Choi; Robert H Eckel; Amy Gallo; Ira J Goldberg; Atsunori Kashiwagi; Aiping Lin; Hiroshi Maegawa; Saki Sono; Hong Wang; Hongyu Zhao; Gerald I Shulman
Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes.
Diabetes 2012;61(4):877-87.
2012: Varman T Samuel; Gerald I Shulman
Mechanisms for insulin resistance: common threads and missing links.
Cell 2012;148(5):852-71.
2012: Wenzhong Liu; Varman T Samuel; Gerald I Shulman; Rajvir Singh; Cheol Soo Choi; Ali R Keramati; Hui-Young Lee; Richard P Lifton; Arya Mani
Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure.
The Journal of biological chemistry 2012;287(10):7213-23.
2012: Jorge Henao-Mejia; Hal M Hoffman; Chengcheng Jin; Michael J Jurczak; Andrew L Kau; Wajahat Z Mehal; Gerald I Shulman; Till Strowig; Christoph A Thaiss; Joao-Paulo Camporez; Stephanie C Eisenbarth; Eran Elinav; Jeffrey I Gordon; Liming Hao; Richard A Flavell
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.
Nature 2012;482(7384):179-85.
2012: François R Jornayvaz; Michael J Jurczak; Hui-Young Lee; Varman T Samuel; Tiago C Alves; Fitsum Guebre-Egziabher; Blas A Guigni; J Enrique Silva; Dongyan Zhang; Gerald I Shulman
Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance.
Endocrinology 2012;153(2):583-91.
2012: Michael J Jurczak; Mario Kahn; Ann-Hwee Lee; Hui-Young Lee; Varman T Samuel; Andreas L Birkenfeld; Laurie H Glimcher; Blas A Guigni; François R Jornayvaz; Gerald I Shulman
Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice.
The Journal of biological chemistry 2012;287(4):2558-67.
2011: Matthew P Gillum; Jennifer J Hsiao; Maya E Kotas; Romy Kursawe; Eric S Muise; Kevin T Nead; Jerrold M Olefsky; Li Qiang; Dorothy D Sears; Alexander S Banks; Sanjay Bhanot; Sonia Caprio; Paula Chatterjee; Derek M Erion; David W Frederick; Shin Yonemitsu; Gerald I Shulman
SirT1 regulates adipose tissue inflammation.
Diabetes 2011;60(12):3235-45.
2011: Rachel A Jamison; Jianying Dong; Gerald I Shulman; Romana Stark; Shin Yonemitsu; Dongyan Zhang; Richard G Kibbey
Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats.
American journal of physiology. Endocrinology and metabolism 2011;301(6):E1174-83.
2011: Alexander S Banks; Rebecca A Haeusler; Garrett Heinrich; Michael J Jurczak; Ja Young Kim-Muller; Natalie M Kofler; Dina Laznik; Teresa L Mastracci; Virginia E Papaioannou; Li Qiang; Varman T Samuel; Gerald I Shulman; Domenico Accili
Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.
Cell metabolism 2011;14(5):587-97.
2011: Hui-Young Lee; Jae-Hak Park; Kitt F Petersen; Violeta Popov; Varman T Samuel; Dongyan Zhang; Kalyani G Bharadwaj; Andreas L Birkenfeld; Cheol Soo Choi; David W Frederick; Ira J Goldberg; Blas Guigni; François R Jornayvaz; Michael J Jurczak; Shoichi Kanda; Gerald I Shulman
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.
Hepatology (Baltimore, Md.) 2011;54(5):1650-60.
2011: Andreas L Birkenfeld; Joao Paulo Camporez; David W Frederick; Blas Guigni; François R Jornayvaz; Michael J Jurczak; Mario Kahn; Hui-Young Lee; Stefanie Lieske; Sachin Majumdar; Seiichi Oyadomari; Andreas F Pfeiffer; David Ron; Varman T Samuel; Dirk Weismann; Dongyang Zhang; Ayman M Arafat; Gerald I Shulman
Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism.
The Journal of biological chemistry 2011;286(42):36163-70.
2011: Naoki Kumashiro; Kitt Falk Petersen; Varman T Samuel; Sara A Beddow; Xin Chu; James Dziura; Derek M Erion; Glenn S Gerhard; Xianlin Han; Mario Kahn; Christopher D Still; Dongyan Zhang; Gerald I Shulman
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(39):16381-5.
2011: Jang Hyun Choi; Alexander S Banks; John B Bruning; Scott A Busby; Michael D Cameron; Michael J Chalmers; Yuanjun He; Michael J Jurczak; Theodore M Kamenecka; Naresh Kumar; Dana S Kuruvilla; Dina Laznik; David P Marciano; Stephan C Schürer; Youseung Shin; Gerald I Shulman; Bruce M Spiegelman; Dušica Vidović; Patrick R Griffin
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.
Nature 2011;477(7365):477-81.
2011: Rasmus Rabøl; Sylvie Dufour; Clare Flannery; Kitt Falk Petersen; Gerald I Shulman
Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13705-9.
2011: Gerald I Shulman; Stephen L Helfand
Indy knockdown in mice mimics elements of dietary restriction.
Aging 2011;3(8):701.
2011: Utpal B Pajvani; Varman T Samuel; Carrie J Shawber; Gerald I Shulman; Andreas L Birkenfeld; Jan Kitajewski; Domenico Accili
Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Nature medicine 2011;17(8):961-7.
2011: Tamas L Horvath; Derek M Erion; John D Elsworth; Robert H Roth; Gerald I Shulman; Zane B Andrews
GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.
Neurobiology of disease 2011;43(1):152-62.
2011: Maryam Ahmadian; Marcia J Abbott; Tianyi Tang; Carolyn S S Hudak; Yangha Kim; Matthew Bruss; Marc K Hellerstein; Hui-Young Lee; Varman T Samuel; Gerald I Shulman; Yuhui Wang; Robin E Duncan; Chulho Kang; Hei Sook Sul
Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype.
Cell metabolism 2011;13(6):739-48.
2011: Douglas E Befroy; Gerald I Shulman
Magnetic resonance spectroscopy studies of human metabolism.
Diabetes 2011;60(5):1361-9.
2011: François R Jornayvaz; Andreas L Birkenfeld; Michael J Jurczak; Shoichi Kanda; Blas A Guigni; Debbie C Jiang; Dongyan Zhang; Hui-Young Lee; Varman T Samuel; Gerald I Shulman
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(14):5748-52.
2011: Tiago C Alves; Douglas Befroy; Richard G Kibbey; Mario Kahn; Roberto Codella; Rui A Carvalho; Kitt Falk Petersen; Gerald I Shulman
Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance.
Hepatology (Baltimore, Md.) 2011;53(4):1175-81.
2011: James W Perfield; Yunkyoung Lee; Gerald I Shulman; Varman T Samuel; Michael J Jurczak; Eugene Chang; Chen Xie; Phillip N Tsichlis; Martin S Obin; Andrew S Greenberg
Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.
Diabetes 2011;60(4):1168-76.
2011: D Weismann; D M Erion; I Ignatova-Todorava; Y Nagai; R Stark; J J Hsiao; C Flannery; A L Birkenfeld; T May; M Kahn; D Zhang; Xing Xian Yu; S F Murray; Sanjay Bhanot; Brett P Monia; Gary W Cline; Gerald I Shulman; Varman T Samuel
Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance.
Diabetologia 2011;54(4):935-44.
2011: Serkan Kir; Sara A Beddow; Varman T Samuel; Paul Miller; Stephen F Previs; Kelly Suino-Powell; H Eric Xu; Gerald I Shulman; Steven A Kliewer; David J Mangelsdorf
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.
Science (New York, N.Y.) 2011;331(6024):1621-4.
2011: Michael J Jurczak; Hui-Young Lee; Andreas L Birkenfeld; Francois R Jornayvaz; David W Frederick; Rebecca L Pongratz; Xiaoxian Zhao; Gilbert W Moeckel; Varman T Samuel; Jean M Whaley; Gerald I Shulman; Richard G Kibbey
SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function.
Diabetes 2011;60(3):890-8.
2011: Hua V Lin; Hongxia Ren; Varman T Samuel; Hui-Young Lee; Taylor Y Lu; Gerald I Shulman; Domenico Accili
Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.
Diabetes 2011;60(3):700-9.
2011: Jessica M Ellis; Shannon M Mentock; Michael A Depetrillo; Timothy R Koves; Shiraj Sen; Steven M Watkins; Deborah M Muoio; Gary W Cline; Heinrich Taegtmeyer; Gerald I Shulman; Monte S Willis; Rosalind A Coleman
Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy.
Molecular and cellular biology 2011;31(6):1252-62.
2011: Dollada Srisai; Matthew P Gillum; Brandon L Panaro; Xian-Man Zhang; Naiphinich Kotchabhakdi; Gerald I Shulman; Kate L J Ellacott; Roger D Cone
Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.
Endocrinology 2011;152(3):890-902.
2011: Maya E Kotas; Hui-Young Lee; Charles Annicelli; Matthew P Gillum; Blas A Guigni; Gerald I Shulman; Ruslan Medzhitov
Impact of CD1d deficiency on metabolism.
PloS one 2011;6(9):e25478.
2011: Cliona M Stapleton; Douglas G Mashek; Shuli Wang; Cynthia A Nagle; Gary W Cline; Philippe Thuillier; Lisa M Leesnitzer; Lei O Li; Julie B Stimmel; Gerald I Shulman; Rosalind A Coleman
Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1.
PloS one 2011;6(4):e18932.
2010: Kalyani G Bharadwaj; Yaeko Hiyama; Yunying Hu; Lesley Ann Huggins; Rajasekhar Ramakrishnan; Nada A Abumrad; Gerald I Shulman; William S Blaner; Ira J Goldberg
Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake.
The Journal of biological chemistry 2010;285(49):37976-86.
2010: Hui-Young Lee; Cheol Soo Choi; Andreas L Birkenfeld; Tiago C Alves; François R Jornayvaz; Michael J Jurczak; Dongyan Zhang; Dong Kyun Woo; Gerald S Shadel; Warren Ladiges; Peter S Rabinovitch; Janine H Santos; Kitt F Petersen; Varman T Samuel; Gerald I Shulman
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.
Cell metabolism 2010;12(6):668-74.
2010: François R Jornayvaz; Michael J Jurczak; Hui-Young Lee; Andreas L Birkenfeld; David W Frederick; Dongyang Zhang; Xian-Man Zhang; Varman T Samuel; Gerald I Shulman
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain.
American journal of physiology. Endocrinology and metabolism 2010;299(5):E808-15.
2010: J Mark Brown; Jenna L Betters; Caleb Lord; Yinyan Ma; Xianlin Han; Kui Yang; Heather M Alger; John Melchior; Janet Sawyer; Ramesh Shah; Martha Wilson; Xiuli Liu; Mark J Graham; Richard Lee; Rosanne M Crooke; Gerald I Shulman; Bingzhong Xue; Hang Shi; Liqing Yu
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance.
Journal of lipid research 2010;51(11):3306-15.
2010: Fawzi Boumezbeur; Kitt F Petersen; Gary W Cline; Graeme F Mason; Kevin L Behar; Gerald I Shulman; Douglas L Rothman
The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(42):13983-91.
2010: Ni Huiping Son; Shuiqing Yu; Joseph Tuinei; Kotaro Arai; Hiroko Hamai; Shunichi Homma; Gerald I Shulman; E Dale Abel; Ira J Goldberg
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.
The Journal of clinical investigation 2010;120(10):3443-54.
2010: Nicola Santoro; Romy Kursawe; Ebe D'Adamo; Daniel J Dykas; Clarence K Zhang; Allen E Bale; Anna M Calí; Deepak Narayan; Melissa M Shaw; Bridget Pierpont; Mary Savoye; Derek Lartaud; Samuel Eldrich; Samuel W Cushman; Hongyu Zhao; Gerald I Shulman; Sonia Caprio
A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents.
Hepatology (Baltimore, Md.) 2010;52(4):1281-90.
2010: Romy Kursawe; Deepak Narayan; Anna M G Cali; Melissa Shaw; Bridget Pierpont; Gerald I Shulman; Sonia Caprio
Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis.
Obesity (Silver Spring, Md.) 2010;18(10):1911-7.
2010: Romy Kursawe; Markus Eszlinger; Deepak Narayan; Teresa Liu; Merlijn Bazuine; Anna M G Cali; Ebe D'Adamo; Melissa Shaw; Bridget Pierpont; Gerald I Shulman; Samuel W Cushman; Arthur Sherman; Sonia Caprio
Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis.
Diabetes 2010;59(9):2288-96.
2010: Julio E Ayala; Varman T Samuel; Gregory J Morton; Silvana Obici; Colleen Croniger; Gerald I Shulman; David H Wasserman; Owen P McGuinness
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice.
Disease models & mechanisms 2010;3(9-10):525-34.
2010: François R Jornayvaz; Varman T Samuel; Gerald I Shulman
The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.
Annual review of nutrition 2010;30():273-90.
2010: Varman T Samuel; Kitt Falk Petersen; Gerald I Shulman
Lipid-induced insulin resistance: unravelling the mechanism.
Lancet 2010;375(9733):2267-77.
2010: William A Chutkow; Andreas L Birkenfeld; Jonathan D Brown; Hui-Young Lee; David W Frederick; Jun Yoshioka; Parth Patwari; Romy Kursawe; Samuel W Cushman; Jorge Plutzky; Gerald I Shulman; Varman T Samuel; Richard T Lee
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity.
Diabetes 2010;59(6):1424-34.
2010: Angela A Wendel; Lei O Li; Yue Li; Gary W Cline; Gerald I Shulman; Rosalind A Coleman
Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity.
Diabetes 2010;59(6):1321-9.
2010: Dongyan Zhang; Jennifer Christianson; Zhen-Xiang Liu; Liqun Tian; Cheol Soo Choi; Susanne Neschen; Jianying Dong; Philip A Wood; Gerald I Shulman
Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency.
Cell metabolism 2010;11(5):402-11.
2010: Derek M Erion; Gerald I Shulman
Diacylglycerol-mediated insulin resistance.
Nature medicine 2010;16(4):400-2.
2010: Catherine S Mitchell; David B Savage; Sylvie Dufour; Nadia Schoenmakers; Peter Murgatroyd; Douglas Befroy; David Halsall; Samantha Northcott; Philippa Raymond-Barker; Suzanne Curran; Elana Henning; Julia Keogh; Penny Owen; John Lazarus; Douglas L Rothman; I Sadaf Farooqi; Gerald I Shulman; Krishna Chatterjee; Kitt Falk Petersen
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia.
The Journal of clinical investigation 2010;120(4):1345-54.
2010: Mandeep Bajaj; Rais Baig; Swangjit Suraamornkul; L Jean Hardies; Dawn K Coletta; Gary W Cline; Adriana Monroy; Shailja Koul; Apiradee Sriwijitkamol; Nicolas Musi; Gerald I Shulman; Ralph DeFronzo
Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus.
The Journal of clinical endocrinology and metabolism 2010;95(4):1916-23.
2010: Kitt Falk Petersen; Sylvie Dufour; Ali Hariri; Carol Nelson-Williams; Jia Nee Foo; Xian-Man Zhang; James Dziura; Richard P Lifton; Gerald I Shulman
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease.
The New England journal of medicine 2010;362(12):1082-9.
2010: François R Jornayvaz; Gerald I Shulman
Regulation of mitochondrial biogenesis.
Essays in biochemistry 2010;47():69-84.
2010: Fawzi Boumezbeur; Graeme F Mason; Robin A de Graaf; Kevin L Behar; Gary W Cline; Gerald I Shulman; Douglas L Rothman; Kitt F Petersen
Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(1):211-21.
2009: Jennifer L Estall; Jorge Ruas; Cheol Soo Choi; Dina Laznik; Michael Badman; Eleftheria Maratos-Flier; Gerald I Shulman; Bruce M Spiegelman
PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(52):22510-5.
2009: Derek M Erion; Irena D Ignatova; Shin Yonemitsu; Yoshio Nagai; Paula Chatterjee; Dirk Weismann; Jennifer J Hsiao; Dongyan Zhang; Takanori Iwasaki; Romana Stark; Clare Flannery; Mario Kahn; Christopher M Carmean; Xing Xian Yu; Susan F Murray; Sanjay Bhanot; Brett P Monia; Gary W Cline; Varman T Samuel; Gerald I Shulman
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein.
Cell metabolism 2009;10(6):499-506.
2009: Rachel J Roth; Annie M Le; Lei Zhang; Mario Kahn; Varman T Samuel; Gerald I Shulman; Anton M Bennett
MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice.
The Journal of clinical investigation 2009;119(12):3817-29.
2009: Karla F Leavens; Rachael M Easton; Gerald I Shulman; Stephen F Previs; Morris J Birnbaum
Akt2 is required for hepatic lipid accumulation in models of insulin resistance.
Cell metabolism 2009;10(5):405-18.
2009: Li Liu; Xiaojing Shi; Cheol Soo Choi; Gerald I Shulman; Katherine Klaus; K Sreekumaran Nair; Gary J Schwartz; Yiying Zhang; Ira J Goldberg; Yi-Hao Yu
Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.
Diabetes 2009;58(11):2516-24.
2009: Lei O Li; Jessica M Ellis; Heather A Paich; Shuli Wang; Nan Gong; George Altshuller; Randy J Thresher; Timothy R Koves; Steven M Watkins; Deborah M Muoio; Gary W Cline; Gerald I Shulman; Rosalind A Coleman
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition.
The Journal of biological chemistry 2009;284(41):27816-26.
2009: Romana Stark; Francisco Pasquel; Adina Turcu; Rebecca L Pongratz; Michael Roden; Gary W Cline; Gerald I Shulman; Richard G Kibbey
Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.
The Journal of biological chemistry 2009;284(39):26578-90.
2009: Varman T Samuel; Sara A Beddow; Takanori Iwasaki; Xian-Man Zhang; Xin Chu; Christopher D Still; Glenn S Gerhard; Gerald I Shulman
Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12121-6.
2009: Derek M Erion; Shin Yonemitsu; Yongzhan Nie; Yoshio Nagai; Matthew P Gillum; Jennifer J Hsiao; Takanori Iwasaki; Romana Stark; Dirk Weismann; Xing Xian Yu; Susan F Murray; Sanjay Bhanot; Brett P Monia; Tamas L Horvath; Qian Gao; Varman T Samuel; Gerald I Shulman
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(27):11288-93.
2009: Sylvie Dufour; Vincent Lebon; Gerald I Shulman; Kitt Falk Petersen
Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans.
American journal of physiology. Endocrinology and metabolism 2009;297(1):E231-5.
2009: Jennifer L Estall; Mario Kahn; Marcus P Cooper; Ffolliott Martin Fisher; Michele K Wu; Dina Laznik; Lishu Qu; David E Cohen; Gerald I Shulman; Bruce M Spiegelman
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Diabetes 2009;58(7):1499-508.
2009: Rebecca L Pongratz; Richard G Kibbey; Clare L Kirkpatrick; Xiaojian Zhao; Marco Pontoglio; moshe yaniv; Claes B Wollheim; Gerald I Shulman; Gary W Cline
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
The Journal of biological chemistry 2009;284(25):16808-21.
2009: Yongzhan Nie; Derek M Erion; Zhenglong Yuan; Marcelo Dietrich; Gerald I Shulman; Tamas L Horvath; Qian Gao
STAT3 inhibition of gluconeogenesis is downregulated by SirT1.
Nature cell biology 2009;11(4):492-500.
2009: Maryam Ahmadian; Robin Duncan; Kristina A. Varady; Danubia Frasson; Marc K Hellerstein; Andreas L Birkenfeld; Varman T Samuel; Gerald I Shulman; Yuhui Wang; Chulho Kang; Hei Sook Sul
Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.
Diabetes 2009;58(4):855-66.
2009: Yoshio Nagai; Shin Yonemitsu; Derek M Erion; Takanori Iwasaki; Romana Stark; Dirk Weismann; Jianying Dong; Dongyan Zhang; Michael J Jurczak; Michael Löffler; James Cresswell; Xing Xian Yu; Susan F Murray; Sanjay Bhanot; Brett P Monia; Jonathan S Bogan; Varman T Samuel; Gerald I Shulman
The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.
Cell metabolism 2009;9(3):252-64.
2009: Kathy Jaworski; Maryam Ahmadian; Robin Duncan; Eszter Sarkadi-Nagy; Kristina A. Varady; Marc K Hellerstein; Hui-Young Lee; Varman T Samuel; Gerald I Shulman; Kee-Hong Kim; Sarah De Val; Chulho Kang; Hei Sook Sul
AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
Nature medicine 2009;15(2):159-68.
2009: Douglas E Befroy; Kitt Falk Petersen; Douglas L Rothman; Gerald I Shulman
Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy.
Methods in enzymology 2009;457():373-93.
2009: Hong Wang; Leslie A Knaub; Dalan R Jensen; Dae Young Jung; Eun-Gyoung Hong; Hwi Jin Ko; Alison M Coates; Ira J Goldberg; Becky A de la Houssaye; Rachel C Janssen; Carrie E McCurdy; Rahman Shaikh; Cheol Soo Choi; Gerald I Shulman; Jason K Kim; Jacob E Friedman; Robert H Eckel
Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.
Diabetes 2009;58(1):116-24.
2009: Glenn C Rowe; Cheol Soo Choi; Lynn Neff; William C Horne; Gerald I Shulman; Roland Baron
Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.
Endocrinology 2009;150(1):135-43.
2008: Josep Villena; Cheol Soo Choi; Yuhui Wang; Sheene Kim; Yu-Jin Hwang; Young-Bum Kim; Gary Cline; Gerald I Shulman; Hei Sook Sul
Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy.
Diabetes 2008;57(12):3258-66.
2008: Matthew P Gillum; Dongyan Zhang; Xian-Man Zhang; Derek M Erion; Rachel A Jamison; Cheolsoo Choi; Jianying Dong; Marya Shanabrough; Hillary R Duenas; David W Frederick; Jennifer J Hsiao; Tamas L Horvath; Chun Min Lo; Pat Tso; Gary W Cline; Gerald I Shulman
N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.
Cell 2008;135(5):813-24.
2008: Douglas Befroy; Kitt Falk Petersen; Sylvie Dufour; Graeme F Mason; Douglas L Rothman; Gerald I Shulman
Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(43):16701-6.
2008: Katsutaro Morino; Susanne Neschen; Stefan Bilz; Saki Sono; Dimitrios Tsirigotis; Richard M Reznick; Irene Moore; Yoshio Nagai; Varman T Samuel; David Sebastian; Morris White; William Philbrick; Gerald I Shulman
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
Diabetes 2008;57(10):2644-51.
2008: Zane B Andrews; Zhong-Wu Liu; Nicholas Walllingford; Derek M Erion; Erzsebet Borok; Jeffery M Friedman; Matthias H Tschöp; Marya Shanabrough; Gary Cline; Gerald I Shulman; Anna Coppola; Xiao-Bing Gao; Tamas L Horvath; Sabrina Diano
UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals.
Nature 2008;454(7206):846-51.
2008: M Faadiel Essop; Heidi S Camp; Cheol Soo Choi; Saumya Sharma; Ryan M Fryer; Glenn A Reinhart; Patrick H Guthrie; Assia Bentebibel; Zeiwei Gu; Gerald I Shulman; Heinrich Taegtmeyer; Salih J Wakil; Lutfi Abu-Elheiga
Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.
American journal of physiology. Heart and circulatory physiology 2008;295(1):H256-65.
2008: Michael J Wolfgang; Seung Hun Cha; David S Millington; Gary Cline; Gerald I Shulman; Suwa Akira; Makoto Asaumi; Takeshi Kurama; Teruhiko Shimokawa; M Daniel Lane
Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight.
Journal of neurochemistry 2008;105(4):1550-9.
2008: Hyeonjin Kim; Sara E Taksali; Sylvie Dufour; Douglas Befroy; T Robin Goodman; Kitt Falk Petersen; Gerald I Shulman; Sonia Caprio; R Todd Constable
Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(3):521-7.
2008: Nika N Danial; Loren D Walensky; Chen-Yu zhang; Cheol Soo Choi; Jill K Fisher; Anthony J A Molina; Sandeep Robert Datta; Kenneth L Pitter; Gregory H Bird; Jakob D Wikstrom; Jude T Deeney; Kirsten Robertson; Joel Morash; Ameya Kulkarni; Susanne Neschen; Sheene Kim; Michael E Greenberg; Barbara E Corkey; orian shirihai; Gerald I Shulman; Bradford B Lowell; Stanley J Korsmeyer
Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Nature medicine 2008;14(2):144-53.
2008: David B Savage; Lanmin Zhai; Balasubramanian Ravikumar; Cheol Soo Choi; Johanna E Snaar; Amanda C McGuire; Sung-Eun Wou; Gema Medina-Gomez; Sheene Kim; Cheryl B Bock; Dyann M Segvich; Bhavana Solanky; Dinesh Deelchand; Antonio Vidal-Puig; Nicholas J Wareham; Gerald I Shulman; Fredrik Karpe; Roy Taylor; Bartholomew A Pederson; Peter J Roach; Stephen O'Rahilly; Anna A DePaoli-Roach
A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice.
PLoS medicine 2008;5(1):e27.
2007: Michael J Wolfgang; Seung Hun Cha; Aniket Sidhaye; Shigeru Chohnan; Gary Cline; Gerald I Shulman; M Daniel Lane
Regulation of hypothalamic malonyl-CoA by central glucose and leptin.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19285-90.
2007: Christoph Handschin; Cheol Soo Choi; Sherry Chin; Sheene Kim; Dan Kawamori; Amarnath J Kurpad; Nicole Neubauer; Jiang Hu; Vamsi K Mootha; Young-Bum Kim; Rohit N Kulkarni; Gerald I Shulman; Bruce M Spiegelman
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.
The Journal of clinical investigation 2007;117(11):3463-74.
2007: Dongyan Zhang; Zhen-Xiang Liu; Cheol Soo Choi; Liqun Tian; Richard G Kibbey; Jianying Dong; Gary W Cline; Philip A Wood; Gerald I Shulman
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17075-80.
2007: Cheol Soo Choi; David B Savage; Lutfi Abu-Elheiga; Zhen-Xiang Liu; Sheene Kim; Ameya Kulkarni; Alberto Distefano; Yu-Jin Hwang; Richard M Reznick; Roberto Codella; Dongyan Zhang; Gary W Cline; Salih J Wakil; Gerald I Shulman
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(42):16480-5.
2007: Ja-Young Kim; Esther van de Wall; Mathieu Laplante; Anthony Azzara; Maria E Trujillo; Susanna M Hofmann; Todd D Schraw; Jorge L Durand; Hua Li; Guangyu Li; Linda Jelicks; Mark F Mehler; David Y Hui; Yves Deshaies; Gerald I Shulman; Gary J Schwartz; Philipp E Scherer
Obesity-associated improvements in metabolic profile through expansion of adipose tissue.
The Journal of clinical investigation 2007;117(9):2621-37.
2007: Cheol Soo Choi; David B Savage; Ameya Kulkarni; Xing Xian Yu; Zhen-Xiang Liu; Katsutaro Morino; Sheene Kim; Alberto Distefano; Varman T Samuel; Susanne Neschen; Dongyan Zhang; Amy Wang; Xian-Man Zhang; Mario Kahn; Gary W Cline; Sanjay K Pandey; John Gerard Geisler; Sanjay Bhanot; Brett P Monia; Gerald I Shulman
Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
The Journal of biological chemistry 2007;282(31):22678-88.
2007: Robert V Farese; Mini P Sajan; Hong Yang; Pengfei Li; Steven Mastorides; William R Gower; Sonali Nimal; Cheol Soo Choi; Sheene Kim; Gerald I Shulman; C Ronald Kahn; Ursula Braun; Michael Leitges
Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
The Journal of clinical investigation 2007;117(8):2289-301.
2007: Kitt Falk Petersen; Sylvie Dufour; David B Savage; Stefan Bilz; Gina Solomon; Shin Yonemitsu; Gary W Cline; Douglas Befroy; Laura Zemany; Barbara B Kahn; Xenophon Papademetris; Douglas L Rothman; Gerald I Shulman
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12587-94.
2007: Cheol Soo Choi; Jonathan J Fillmore; Jason K Kim; Zhen-Xiang Liu; Sheene Kim; Emily F Collier; Ameya Kulkarni; Alberto Distefano; Yu-Jin Hwang; Mario Kahn; Yan Chen; Chunli Yu; Irene K Moore; Richard M Reznick; Takamasa Higashimori; Gerald I Shulman
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance.
The Journal of clinical investigation 2007;117(7):1995-2003.
2007: Cynthia A Nagle; Jie An; Masakazu Shiota; Tracy P Torres; Gary W Cline; Zhen-Xiang Liu; Shuli Wang; Reetta L Catlin; Gerald I Shulman; Christopher B Newgard; Rosalind A Coleman
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance.
The Journal of biological chemistry 2007;282(20):14807-15.
2007: Qingchun Tong; Chianping Ye; Rory J McCrimmon; Harveen Dhillon; Brian Choi; Melissa D Kramer; Jia Yu; Zongfang Yang; Lauryn M Christiansen; Charlotte E Lee; Cheol Soo Choi; Jeffrey M Zigman; Gerald I Shulman; Robert S Sherwin; Joel K Elmquist; Bradford B Lowell
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
Cell metabolism 2007;5(5):383-93.
2007: Douglas Befroy; Kitt Falk Petersen; Sylvie Dufour; Graeme F Mason; Robin A de Graaf; Douglas L Rothman; Gerald I Shulman
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients.
Diabetes 2007;56(5):1376-81.
2007: David B Savage; Kitt Falk Petersen; Gerald I Shulman
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Physiological reviews 2007;87(2):507-20.
2007: Richard G Kibbey; Rebecca L Pongratz; Anthony J Romanelli; Claes B Wollheim; Gary W Cline; Gerald I Shulman
Mitochondrial GTP regulates glucose-stimulated insulin secretion.
Cell metabolism 2007;5(4):253-64.
2007: Susanne Neschen; Katsutaro Morino; Jianying Dong; Yanlin Wang-Fischer; Gary W Cline; Anthony J Romanelli; Jörg Rossbacher; Irene K Moore; Werner Regittnig; David S Munoz; Jung H Kim; Gerald I Shulman
n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.
Diabetes 2007;56(4):1034-41.
2007: Jonathan B Hurov; Mei Huang; Lynn S White; Jochen Lennerz; Cheol Soo Choi; You-Ree Cho; Hyo-Jeong Kim; Julie L Prior; David Piwnica-Worms; Lewis C Cantley; Jason K Kim; Gerald I Shulman; Helen Piwnica-Worms
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(13):5680-5.
2007: Varman T Samuel; Zhen-Xiang Liu; Amy Wang; Sara A Beddow; John Gerard Geisler; Mario Kahn; Xian-Man Zhang; Brett P Monia; Sanjay Bhanot; Gerald I Shulman
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease.
The Journal of clinical investigation 2007;117(3):739-45.
2007: Richard M Reznick; Haihong Zong; Li Ji; Katsutaro Morino; Irene K Moore; Hannah J Yu; Zhen-Xiang Liu; Jianying Dong; Kirsty J Mustard; Simon A Hawley; Douglas Befroy; Marc Pypaert; D Grahame Hardie; Lawrence H Young; Gerald I Shulman
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis.
Cell metabolism 2007;5(2):151-6.
2007: Rebecca L Pongratz; Richard G Kibbey; Gerald I Shulman; Gary W Cline
Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.
The Journal of biological chemistry 2007;282(1):200-7.
2007: David Liska; Sylvie Dufour; Tosca L Zern; Sara E Taksali; Anna M G Calí; James Dziura; Gerald I Shulman; Bridget M Pierpont; Sonia Caprio
Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents.
PloS one 2007;2(6):e569.
2007: Qian Gao; Gábor Mezei; Yongzhan Nie; Yan Rao; Cheol Soo Choi; Ingo Bechmann; Csaba Leranth; Dominique Toran-Allerand; Catherine A Priest; James Roberts; Xiao-Bing Gao; Charles V Mobbs; Gerald I Shulman; Sabrina Diano; Tamas L Horvath
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals.
Nature medicine 2007;13(1):89-94.
2007: Graeme F Mason; Kitt Falk Petersen; Robin A de Graaf; Gerald I Shulman; Douglas L Rothman
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose.
Journal of neurochemistry 2007;100(1):73-86.
2006: Claudia R Vianna; Michael Huntgeburth; Roberto Coppari; Cheol Soo Choi; Jiandie Lin; Stefan Krauss; Giorgio Barbatelli; Iphigenia Tzameli; Young-Bum Kim; Saverio Cinti; Gerald I Shulman; Bruce M Spiegelman; Bradford B Lowell
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Cell metabolism 2006;4(6):453-64.
2006: Katsutaro Morino; Kitt Falk Petersen; Gerald I Shulman
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction.
Diabetes 2006;55 Suppl 2():S9-S15.
2006: Kitt Falk Petersen; Sylvie Dufour; Jing Feng; Douglas Befroy; James Dziura; Chiara Dalla Man; Claudio Cobelli; Gerald I Shulman
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(48):18273-7.
2006: Alon Chen; Bhawanjit K Brar; Cheol Soo Choi; David Rousso; Joan Vaughan; Yael Kuperman; Shee Ne Kim; Cynthia J Donaldson; Sean M Smith; Pauline M Jamieson; Chien Li; Tim Nagy; Gerald I Shulman; Kuo-Fen Lee; Wylie Vale
Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(44):16580-5.
2006: Heidi Sørensen; Christian L Brand; Susanne Neschen; Jens Juul Holst; Keld Fosgerau; Erica Nishimura; Gerald I Shulman
Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.
Diabetes 2006;55(10):2843-8.
2006: So-Young Park; You-Ree Cho; Hyo-Jeong Kim; Eun-Gyoung Hong; Takamasa Higashimori; Sang Jun Lee; Ira J Goldberg; Gerald I Shulman; Sonia M Najjar; Jason K Kim
Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.
American journal of physiology. Endocrinology and metabolism 2006;291(3):E517-24.
2006: J Julie Wu; Rachel J Roth; Ethan J Anderson; Eun-Gyoung Hong; Mi-Kyung Lee; Cheol Soo Choi; P Darrell Neufer; Gerald I Shulman; Jason K Kim; Anton M Bennett
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.
Cell metabolism 2006;4(1):61-73.
2006: Varman T Samuel; Cheol Soo Choi; Trevor G Phillips; Anthony J Romanelli; John Gerard Geisler; Sanjay Bhanot; Robert McKay; Brett P Monia; John R Shutter; Richard A Lindberg; Gerald I Shulman; Murielle M Veniant
Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.
Diabetes 2006;55(7):2042-50.
2006: Haiming Cao; Kazuhisa Maeda; Cem Z Gorgun; Hyo-Jeong Kim; So-Young Park; Gerald I Shulman; Jason K Kim; Gökhan S Hotamisligil
Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.
Diabetes 2006;55(7):1915-22.
2006: Richard M Reznick; Gerald I Shulman
The role of AMP-activated protein kinase in mitochondrial biogenesis.
The Journal of physiology 2006;574(Pt 1):33-9.
2006: Marie-Julie Dubois; Sébastien Bergeron; Hyo-Jeong Kim; Luce Dombrowski; Mylène Perreault; Bénédicte Fournès; Robert Faure; Martin Olivier; Nicole Beauchemin; Gerald I Shulman; Katherine A Siminovitch; Jason K Kim; André Marette
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Nature medicine 2006;12(5):549-56.
2006: Kitt Falk Petersen; Gerald I Shulman
Etiology of insulin resistance.
The American journal of medicine 2006;119(5 Suppl 1):S10-6.
2006: Ann Vogel Hertzel; Lisa Ann Smith; Anders H Berg; Gary W Cline; Gerald I Shulman; Philipp E Scherer; David A Bernlohr
Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice.
American journal of physiology. Endocrinology and metabolism 2006;290(5):E814-23.
2006: Graeme F Mason; Kitt Falk Petersen; Vincent Lebon; Douglas L Rothman; Gerald I Shulman
Increased brain monocarboxylic acid transport and utilization in type 1 diabetes.
Diabetes 2006;55(4):929-34.
2006: Susanne Neschen; Katsutaro Morino; Jörg Rossbacher; Rebecca L Pongratz; Gary W Cline; Saki Sono; Matthew Gillum; Gerald I Shulman
Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice.
Diabetes 2006;55(4):924-8.
2006: Stefan Bilz; Varman T Samuel; Katsutaro Morino; David Savage; Cheol Soo Choi; Gerald I Shulman
Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters.
American journal of physiology. Endocrinology and metabolism 2006;290(4):E716-22.
2006: David B Savage; Cheol Soo Choi; Varman T Samuel; Zhen-Xiang Liu; Dongyan Zhang; Amy Wang; Xian-Man Zhang; Gary W Cline; Xing Xian Yu; John Gerard Geisler; Sanjay Bhanot; Brett P Monia; Gerald I Shulman
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.
The Journal of clinical investigation 2006;116(3):817-24.
2006: Kitt Falk Petersen; Gerald I Shulman
New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy.
Obesity (Silver Spring, Md.) 2006;14 Suppl 1():34S-40S.
2005: Katsutaro Morino; Kitt Falk Petersen; Sylvie Dufour; Douglas Befroy; Jared C Frattini; Nadine Shatzkes; Susanne Neschen; Morris F White; Stefan Bilz; Saki Sono; Marc Pypaert; Gerald I Shulman
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
The Journal of clinical investigation 2005;115(12):3587-93.
2005: Mandeep Bajaj; Swangjit Suraamornkul; Anthony Romanelli; Gary W Cline; Lawrence J. Manderino; Gerald I Shulman; Ralph DeFronzo
Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes 2005;54(11):3148-53.
2005: Elisabeth Bernroider; Attila Brehm; Martin Krssak; Christian Anderwald; Zlatko Trajanoski; Gary W Cline; Gerald I Shulman; Michael Roden
The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes.
The Journal of clinical endocrinology and metabolism 2005;90(10):5559-65.
2005: Kitt Falk Petersen; Sylvie Dufour; Gerald I Shulman
Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.
PLoS medicine 2005;2(9):e233.
2005: Linda E Hammond; Susanne Neschen; Anthony J Romanelli; Gary W Cline; Olga Ilkayeva; Gerald I Shulman; Deborah M Muoio; Rosalind A Coleman
Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.
The Journal of biological chemistry 2005;280(27):25629-36.
2005: Susanne Neschen; Katsutaro Morino; Linda E Hammond; Dongyan Zhang; Zhen-Xiang Liu; Anthony J Romanelli; Gary W Cline; Rebecca L Pongratz; Xian-Man Zhang; Cheol Soo Choi; Rosalind A Coleman; Gerald I Shulman
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.
Cell metabolism 2005;2(1):55-65.
2005: So-Young Park; Hyo-Jeong Kim; Shupei Wang; Takamasa Higashimori; Jianying Dong; Yoon-Jung Kim; Gary W Cline; Hong Li; Marc Prentki; Gerald I Shulman; Grant A Mitchell; Jason K Kim
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart.
American journal of physiology. Endocrinology and metabolism 2005;289(1):E30-9.
2005: Jason K Kim; Hyo-Jeong Kim; So-Young Park; Anna Cederberg; Rickard Westergren; Daniel Nilsson; Takamasa Higashimori; You-Ree Cho; Zhen-Xiang Liu; Jianying Dong; Gary W Cline; Sven Enerback; Gerald I Shulman
Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance.
Diabetes 2005;54(6):1657-63.
2005: Ram Weiss; Sara E Taksali; Sylvie Dufour; Catherine W Yeckel; Xenophon Papademetris; Gary W Cline; William V Tamborlane; James Dziura; Gerald I Shulman; Sonia Caprio
The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning.
The Journal of clinical endocrinology and metabolism 2005;90(6):3731-7.
2005: David B Savage; Kitt Falk Petersen; Gerald I Shulman
Mechanisms of insulin resistance in humans and possible links with inflammation.
Hypertension 2005;45(5):828-33.
2005: Kitt Falk Petersen; Sylvie Dufour; Douglas Befroy; Michael Lehrke; Rosa E Hendler; Gerald I Shulman
Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes.
Diabetes 2005;54(3):603-8.
2005: Walter N Kernan; Catherine M Viscoli; Silvio E Inzucchi; Lawrence M Brass; Dawn M Bravata; Gerald I Shulman; James C McVeety
Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke.
Archives of internal medicine 2005;165(2):227-33.
2005: Bradford B Lowell; Gerald I Shulman
Mitochondrial dysfunction and type 2 diabetes.
Science (New York, N.Y.) 2005;307(5708):384-7.
2004: Martin Krssak; Attila Brehm; Elisabeth Bernroider; Christian Anderwald; Peter Nowotny; Chiara Dalla Man; Claudio Cobelli; Gary W Cline; Gerald I Shulman; Werner Waldhäusl; Michael Roden
Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.
Diabetes 2004;53(12):3048-56.
2004: Frederick H Wilson; Ali Hariri; anita farhi; Hongyu Zhao; Kitt Falk Petersen; Hakan R Toka; Carol Nelson-Williams; Khalid M Raja; Michael Kashgarian; Gerald I Shulman; Steven J Scheinman; Richard P Lifton
A cluster of metabolic defects caused by mutation in a mitochondrial tRNA.
Science (New York, N.Y.) 2004;306(5699):1190-4.
2004: Gary W Cline; Rebecca L Lepine; Klearchos K Papas; Richard G Kibbey; Gerald I Shulman
13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.
The Journal of biological chemistry 2004;279(43):44370-5.
2004: Jiandie Lin; Pei-Hsuan Wu; Paul T Tarr; Katrin S Lindenberg; Julie St-Pierre; Chen-Yu zhang; Vamsi K Mootha; Sibylle Jäger; Claudia R Vianna; Richard M Reznick; Libin Cui; Monia Manieri; Mi X Donovan; Zhidan Wu; Marcus P Cooper; Melina C Fan; Lindsay M Rohas; Ann Marie Zavacki; Saverio Cinti; Gerald I Shulman; Bradford B Lowell; Dimitri Krainc; Bruce M Spiegelman
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Cell 2004;119(1):121-35.
2004: Jason K Kim; Jonathan J Fillmore; Mary Jean Sunshine; Bjoern Albrecht; Takamasa Higashimori; Dong-Wook Kim; Zhen-Xiang Liu; Timothy J Soos; Gary W Cline; William R O'Brien; Dan R Littman; Gerald I Shulman
PKC-theta knockout mice are protected from fat-induced insulin resistance.
The Journal of clinical investigation 2004;114(6):823-7.
2004: Gerald I Shulman
Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy.
Physiology (Bethesda, Md.) 2004;19():183-90.
2004: Varman T Samuel; Zhen-Xiang Liu; Xianqin Qu; Benjamin D Elder; Stefan Bilz; Douglas Befroy; Anthony J Romanelli; Gerald I Shulman
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.
The Journal of biological chemistry 2004;279(31):32345-53.
2004: Janice M Zabolotny; Fawaz G Haj; Young-Bum Kim; Hyo-Jeong Kim; Gerald I Shulman; Jason K Kim; Benjamin G Neel; Barbara B Kahn
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
The Journal of biological chemistry 2004;279(23):24844-51.
2004: Qi Shen; Gary W Cline; Gerald I Shulman; Mark D Leibowitz; Peter Davies
Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice.
The Journal of biological chemistry 2004;279(19):19721-31.
2004: Qian Gao; Michael J Wolfgang; Susanne Neschen; Katsutaro Morino; Tamas L Horvath; Gerald I Shulman; Xin-Yuan Fu
Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4661-6.
2004: Jason K Kim; Ruth E Gimeno; Takamasa Higashimori; Hyo-Jeong Kim; Hyejeong Choi; Sandhya Punreddy; Robin L Mozell; Guo Tan; Alain Stricker-Krongrad; David J Hirsch; Jonathan J Fillmore; Zhen-Xiang Liu; Jianying Dong; Gary W Cline; Andreas Stahl; Harvey Lodish; Gerald I Shulman
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle.
The Journal of clinical investigation 2004;113(5):756-63.
2004: Jie An; Deborah M Muoio; Masakazu Shiota; Yuka Fujimoto; Gary W Cline; Gerald I Shulman; Timothy R Koves; Robert Stevens; David S Millington; Christopher B Newgard
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance.
Nature medicine 2004;10(3):268-74.
2004: Kitt Falk Petersen; Sylvie Dufour; Douglas Befroy; Rina Garcia; Gerald I Shulman
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.
The New England journal of medicine 2004;350(7):664-71.
2004: Erdal Erol; Leena S Kumar; Gary W Cline; Gerald I Shulman; Daniel P Kelly; Bert Binas
Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):347-9.
2003: Harold W Goforth; Didier Laurent; William K Prusaczyk; Kevin E Schneider; Kitt Falk Petersen; Gerald I Shulman
Effects of depletion exercise and light training on muscle glycogen supercompensation in men.
American journal of physiology. Endocrinology and metabolism 2003;285(6):E1304-11.
2003: Shamina M Rangwala; Ben Rhoades; Jennifer S Shapiro; A Sophie Rich; Jason K Kim; Gerald I Shulman; Klaus kaestner; Mitchell Lazar
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.
Developmental cell 2003;5(4):657-63.
2003: Ram Weiss; Sylvie Dufour; Sara E Taksali; William V Tamborlane; Kitt Falk Petersen; Riccardo C Bonadonna; Linda Boselli; Gina Barbetta; Karin Allen; Fran Rife; Mary Savoye; James Dziura; Robert S Sherwin; Gerald I Shulman; Sonia Caprio
Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning.
Lancet 2003;362(9388):951-7.
2003: David L Coven; Xiaoyue Hu; Lin Cong; Raynald Bergeron; Gerald I Shulman; D Grahame Hardie; Lawrence H Young
Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise.
American journal of physiology. Endocrinology and metabolism 2003;285(3):E629-36.
2003: Beth A Spurlin; Rhonda M Thomas; Angela K Nevins; Hyo-Jeong Kim; Yoon-Jung Kim; Hye-Lim Noh; Gerald I Shulman; Jason K Kim; Debbie C Thurmond
Insulin resistance in tetracycline-repressible Munc18c transgenic mice.
Diabetes 2003;52(8):1910-7.
2003: Markus R Wenk; Louise Lucast; Gilbert Di Paolo; Anthony J Romanelli; Sharon F Suchy; Robert L Nussbaum; Gary W Cline; Gerald I Shulman; Walter McMurray; Pietro De Camilli
Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry.
Nature biotechnology 2003;21(7):813-7.
2003: Jason K Kim; Jonathan J Fillmore; Oksana Gavrilova; Lily Chao; Takamasa Higashimori; Hyejeong Choi; Hyo-Jeong Kim; Chunli Yu; Yan Chen; Xianqin Qu; Martin Haluzik; Marc L Reitman; Gerald I Shulman
Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice.
Diabetes 2003;52(6):1311-8.
2003: Walter N Kernan; Silvio E Inzucchi; Catherine M Viscoli; Lawrence M Brass; Dawn M Bravata; Gerald I Shulman; James C McVeety; Ralph I Horwitz
Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke.
Stroke; a journal of cerebral circulation 2003;34(6):1431-6.
2003: Kitt Falk Petersen; Douglas Befroy; Sylvie Dufour; James Dziura; Charlotte Eielson Ariyan; Douglas L Rothman; Loretta DiPietro; Gary W Cline; Gerald I Shulman
Mitochondrial dysfunction in the elderly: possible role in insulin resistance.
Science (New York, N.Y.) 2003;300(5622):1140-2.
2003: Walter N Kernan; Silvio E Inzucchi; Catherine M Viscoli; Lawrence M Brass; Dawn M Bravata; Gerald I Shulman; James C McVeety; Ralph I Horwitz
Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke.
Neurology 2003;60(9):1447-51.
2003: Staffan Enoksson; Sonia Caprio; Fran Rife; Gerald I Shulman; William V Tamborlane; Robert S Sherwin
Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia.
The Journal of clinical endocrinology and metabolism 2003;88(4):1503-11.
2003: Matthew W Hulver; Jason R Berggren; Ronald N Cortright; Ronald W Dudek; R Peter Thompson; Walter J Pories; Kenneth G MacDonald; Gary W Cline; Gerald I Shulman; G Lynis Dohm; Joseph A Houmard
Skeletal muscle lipid metabolism with obesity.
American journal of physiology. Endocrinology and metabolism 2003;284(4):E741-7.
2003: Monica A Borg; William V Tamborlane; Gerald I Shulman; Robert S Sherwin
Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation.
Diabetes 2003;52(3):663-6.
2003: Graeme F Mason; Kitt Falk Petersen; Robin A de Graaf; Tomoyuki Kanamatsu; Taisuke Otsuki; Gerald I Shulman; Douglas L Rothman
A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose.
Brain research. Brain research protocols 2003;10(3):181-90.
2002: Chunli Yu; Yan Chen; Gary W Cline; Dongyan Zhang; Haihong Zong; Yanlin Wang; Raynald Bergeron; Jason K Kim; Samuel W Cushman; Gregory J Cooney; Bronwyn Atcheson; Morris F White; Edward W Kraegen; Gerald I Shulman
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
The Journal of biological chemistry 2002;277(52):50230-6.
2002: Haihong Zong; Jian Ming Ren; Lawrence H Young; Marc Pypaert; James Mu; Morris J Birnbaum; Gerald I Shulman
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15983-7.
2002: Rory J McCrimmon; Mark L Evans; Ralph J Jacob; Xiaoning Fan; Y Zhu; Gerald I Shulman; Robert S Sherwin
AICAR and phlorizin reverse the hypoglycemia-specific defect in glucagon secretion in the diabetic BB rat.
American journal of physiology. Endocrinology and metabolism 2002;283(5):E1076-83.
2002: Joseph A Houmard; Charles J Tanner; Chunli Yu; Paul G Cunningham; Walter J Pories; Kenneth G MacDonald; Gerald I Shulman
Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects.
Diabetes 2002;51(10):2959-63.
2002: Gary W Cline; Kirk Johnson; Werner Regittnig; Pascale Perret; Effie Tozzo; Linda Xiao; Christine Damico; Gerald I Shulman
Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats.
Diabetes 2002;51(10):2903-10.
2002: Young-Bum Kim; Gerald I Shulman; Barbara B Kahn
Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.
The Journal of biological chemistry 2002;277(36):32915-22.
2002: Kitt Falk Petersen; Gerald I Shulman
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus.
The American journal of cardiology 2002;90(5A):11G-18G.
2002: Silvio E Inzucchi; Kitt Falk Petersen; Gerald I Shulman
Nonalcoholic fatty liver disease.
The New England journal of medicine 2002;347(10):768-9; author reply 768-9.
2002: Jullie W Pan; Robin A de Graaf; Kitt Falk Petersen; Gerald I Shulman; Hoby P Hetherington; Douglas L Rothman
[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(7):890-8.
2002: Martin Haluzik; Kelly R Dietz; Jason K Kim; Bernice Marcus-Samuels; Gerald I Shulman; Oksana Gavrilova; Marc L Reitman
Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity.
Diabetes 2002;51(7):2113-8.
2002: Kitt Falk Petersen; Elif Arioglu Oral; Sylvie Dufour; Douglas Befroy; Charlotte Eielson Ariyan; Chunli Yu; Gary W Cline; Alex M DePaoli; Simeon I Taylor; Phillip Gorden; Gerald I Shulman
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy.
The Journal of clinical investigation 2002;109(10):1345-50.
2002: Ripudaman S Hundal; Kitt Falk Petersen; Adam B Mayerson; Pritpal S Randhawa; Silvio E Inzucchi; Steven E Shoelson; Gerald I Shulman
Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes.
The Journal of clinical investigation 2002;109(10):1321-6.
2002: Ranjana Sinha; Sylvie Dufour; Kitt Falk Petersen; Vincent Lebon; Staffan Enoksson; Yong-Zhan Ma; Mary Savoye; Douglas L Rothman; Gerald I Shulman; Sonia Caprio
Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity.
Diabetes 2002;51(4):1022-7.
2002: Vincent Lebon; Kitt Falk Petersen; Gary W Cline; Jun Shen; Graeme F Mason; Sylvie Dufour; Kevin L Behar; Gerald I Shulman; Douglas L Rothman
Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):1523-31.
2002: Adam B Mayerson; Ripudaman S Hundal; Sylvie Dufour; Vincent Lebon; Douglas Befroy; Gary W Cline; Staffan Enocksson; Silvio E Inzucchi; Gerald I Shulman; Kitt Falk Petersen
The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes.
Diabetes 2002;51(3):797-802.
2002: Masakazu Shiota; Mary Courtney Moore; Pietro Galassetti; Michael Monohan; Doss W Neal; Gerald I Shulman; Alan D Cherrington
Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.
Diabetes 2002;51(2):469-78.
2002: Susanne Neschen; Irene Moore; Werner Regittnig; Chun Li Yu; Yanlin Wang; Marc Pypaert; Kitt Falk Petersen; Gerald I Shulman
Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.
American journal of physiology. Endocrinology and metabolism 2002;282(2):E395-401.
2002: Kitt Falk Petersen; Gerald I Shulman
Cellular mechanism of insulin resistance in skeletal muscle.
Journal of the Royal Society of Medicine 2002;95 Suppl 42():8-13.
2002: Martin G Bischof; Elisabeth Bernroider; Martin Krssak; Michael Krebs; Harald Stingl; Peter Nowotny; Chunlin Yu; Gerald I Shulman; Werner Waldhäusl; Michael Roden
Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia.
Diabetes 2002;51(1):49-54.
2001: Raynald Bergeron; Jian Ming Ren; KS Cadman; Irene K Moore; Pascale Perret; Marc Pypaert; Lawrence H Young; C F Semenkovich; Gerald I Shulman
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis.
American journal of physiology. Endocrinology and metabolism 2001;281(6):E1340-6.
2001: Vincent Lebon; Sylvie Dufour; Kitt Falk Petersen; J Ren; BM Jucker; Lori A Slezak; Gary W Cline; Douglas L Rothman; Gerald I Shulman
Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle.
The Journal of clinical investigation 2001;108(5):733-7.
2001: Jason K Kim; Yoon-Jung Kim; Jonathan J Fillmore; Yibang Chen; I Moore; J Lee; M Yuan; Z W Li; Michael Karin; Pascale Perret; Steven E Shoelson; Gerald I Shulman
Prevention of fat-induced insulin resistance by salicylate.
The Journal of clinical investigation 2001;108(3):437-46.
2001: Jason K Kim; Ariel Zisman; Jonathan J Fillmore; Odile D Peroni; Ko Kotani; Pascale Perret; Haihong Zong; Jianying Dong; C Ronald Kahn; Barbara B Kahn; Gerald I Shulman
Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4.
The Journal of clinical investigation 2001;108(1):153-60.
2001: Jason K Kim; Jonathan J Fillmore; Yibang Chen; Chunli Yu; Irene K Moore; Marc Pypaert; E Peer Lutz; Yuko Kako; W Velez-Carrasco; Ira J Goldberg; Jan L Breslow; Gerald I Shulman
Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7522-7.
2001: Chen-Yu zhang; György Baffy; P Perret; S Krauss; Odile D Peroni; D Grujic; T Hagen; Antonio Vidal-Puig; Olivier Boss; Y B Kim; X X Zheng; M B Wheeler; Gerald I Shulman; C B Chan; Bradford B Lowell
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.
Cell 2001;105(6):745-55.
2001: Gary W Cline; antonio vidal-puig; Sylvie Dufour; KS Cadman; B B Lowell; Gerald I Shulman
In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism.
The Journal of biological chemistry 2001;276(23):20240-4.
2001: Han Cho; James Mu; Jason K Kim; Joanne L Thorvaldsen; Q Chu; E Bryan Crenshaw; Klaus kaestner; Marisa S Bartolomei; Gerald I Shulman; Morris J Birnbaum
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta).
Science (New York, N.Y.) 2001;292(5522):1728-31.
2001: Kitt Falk Petersen; Didier Laurent; Chunli Yu; Gary W Cline; Gerald I Shulman
Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans.
Diabetes 2001;50(6):1263-8.
2001: Chunmei Yang; Kenneth Coker; J K Kim; Silvia Mora; Debbie C Thurmond; A C Davis; Baoli Yang; R A Williamson; Gerald I Shulman; Jeffrey Pessin
Syntaxin 4 heterozygous knockout mice develop muscle insulin resistance.
The Journal of clinical investigation 2001;107(10):1311-8.
2001: Raynald Bergeron; Stephen Previs; Gary W Cline; Pascale Perret; Raymond R Russell; Lawrence H Young; Gerald I Shulman
Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.
Diabetes 2001;50(5):1076-82.
2001: Kitt Falk Petersen; G W Cline; D P Gerard; I Magnusson; D L Rothman; Gerald I Shulman
Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans.
Metabolism: clinical and experimental 2001;50(5):598-601.
2001: Janice M Zabolotny; Young-Bum Kim; Odile D Peroni; Jason K Kim; Michael Aleksander Pani; Olivier Boss; Lori D Klaman; S Kamatkar; Gerald I Shulman; Barbara B Kahn; Benjamin G Neel
Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(9):5187-92.
2001: E Dale Abel; Odile D Peroni; J K Kim; Y B Kim; Olivier Boss; E Hadro; T Minnemann; Gerald I Shulman; Barbara B Kahn
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver.
Nature 2001;409(6821):729-33.
2001: Michael Roden; K F Petersen; Gerald I Shulman
Nuclear magnetic resonance studies of hepatic glucose metabolism in humans.
Recent progress in hormone research 2001;56():219-37.
2001: Harald Stingl; Martin Krssák; Michael Krebs; Martin G Bischof; Peter Nowotny; Clemens Fürnsinn; Gerald I Shulman; Werner Waldhäusl; Michael Roden
Lipid-dependent control of hepatic glycogen stores in healthy humans.
Diabetologia 2001;44(1):48-54.
2001: Liangyou Rui; Vincent Aguirre; J K Kim; Gerald I Shulman; A Lee; Anne Corbould; Andrea Dunaif; Morris F White
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways.
The Journal of clinical investigation 2001;107(2):181-9.
2000: BM Jucker; J Ren; Sylvie Dufour; X Cao; Stephen Previs; KS Cadman; Gerald I Shulman
13C/31P NMR assessment of mitochondrial energy coupling in skeletal muscle of awake fed and fasted rats. Relationship with uncoupling protein 3 expression.
The Journal of biological chemistry 2000;275(50):39279-86.
2000: Stephen Previs; DJ Withers; Jian Ming Ren; Morris F White; Gerald I Shulman
Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.
The Journal of biological chemistry 2000;275(50):38990-4.
2000: Ripudaman S Hundal; Martin Krssak; Sylvie Dufour; Didier Laurent; Vincent Lebon; Visvanathan Chandramouli; Silvio E Inzucchi; William C Schumann; Kitt Falk Petersen; Bernard R Landau; Gerald I Shulman
Mechanism by which metformin reduces glucose production in type 2 diabetes.
Diabetes 2000;49(12):2063-9.
2000: Lori D Klaman; Olivier Boss; Odile D Peroni; Jason K Kim; J L Martino; Janice M Zabolotny; N Moghal; M Lubkin; Young-Bum Kim; A H Sharpe; Alain Stricker-Krongrad; Gerald I Shulman; Benjamin G Neel; Barbara B Kahn
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.
Molecular and cellular biology 2000;20(15):5479-89.
2000: M Dodson Michael; Rohit N Kulkarni; C Postic; Stephen Previs; Gerald I Shulman; Mark Magnuson; C Ronald Kahn
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
Molecular cell 2000;6(1):87-97.
2000: Gerald I Shulman
Cellular mechanisms of insulin resistance.
The Journal of clinical investigation 2000;106(2):171-6.
2000: PH McNulty; Gary W Cline; JM Whiting; Gerald I Shulman
Regulation of myocardial [(13)C]glucose metabolism in conscious rats.
American journal of physiology. Heart and circulatory physiology 2000;279(1):H375-81.
2000: BM Jucker; Sylvie Dufour; J Ren; X Cao; Stephen Previs; B Underhill; KS Cadman; Gerald I Shulman
Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(12):6880-4.
2000: Jason K Kim; M Dodson Michael; Stephen Previs; Odile D Peroni; Franck Mauvais-Jarvis; Susanne Neschen; Barbara B Kahn; C Ronald Kahn; Gerald I Shulman
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle.
The Journal of clinical investigation 2000;105(12):1791-7.
2000: Didier Laurent; K E Schneider; W K Prusaczyk; C Franklin; SM Vogel; Martin Krssak; Kitt Falk Petersen; H W Goforth; Gerald I Shulman
Effects of caffeine on muscle glycogen utilization and the neuroendocrine axis during exercise.
The Journal of clinical endocrinology and metabolism 2000;85(6):2170-5.
2000: Kitt Falk Petersen; Martin Krssak; Silvio E Inzucchi; Gary W Cline; Sylvie Dufour; Gerald I Shulman
Mechanism of troglitazone action in type 2 diabetes.
Diabetes 2000;49(5):827-31.
2000: Michael Roden; Harald Stingl; Visvanathan Chandramouli; William C Schumann; Astrid Hofer; Bernard R Landau; Peter Nowotny; Werner Waldhäusl; Gerald I Shulman
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.
Diabetes 2000;49(5):701-7.
2000: Didier Laurent; Ripudaman S Hundal; A Dresner; Thomas B Price; SM Vogel; Kitt Falk Petersen; Gerald I Shulman
Mechanism of muscle glycogen autoregulation in humans.
American journal of physiology. Endocrinology and metabolism 2000;278(4):E663-8.
2000: Jian Ming Ren; N Barucci; Bess A Marshall; P Hansen; Mike Mueckler; Gerald I Shulman
Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise.
American journal of physiology. Endocrinology and metabolism 2000;278(4):E588-92.
2000: Jason K Kim; Oksana Gavrilova; Yibang Chen; Marc L Reitman; Gerald I Shulman
Mechanism of insulin resistance in A-ZIP/F-1 fatless mice.
The Journal of biological chemistry 2000;275(12):8456-60.
2000: PH McNulty; Dinesh H Jagasia; Gary W Cline; CK Ng; JM Whiting; P Garg; Gerald I Shulman; Robert Soufer
Persistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion.
Circulation 2000;101(8):917-22.
2000: Martin Krssak; Kitt Falk Petersen; Raynald Bergeron; T Price; Didier Laurent; Douglas L Rothman; Michael Roden; Gerald I Shulman
Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study.
The Journal of clinical endocrinology and metabolism 2000;85(2):748-54.
2000: Oksana Gavrilova; Bernice Marcus-Samuels; D Graham; J K Kim; Gerald I Shulman; AL Castle; Charles Vinson; Michael Eckhaus; Marc L Reitman
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.
The Journal of clinical investigation 2000;105(3):271-8.
2000: Thomas B Price; Didier Laurent; Kitt Falk Petersen; Douglas L Rothman; Gerald I Shulman
Glycogen loading alters muscle glycogen resynthesis after exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(2):698-704.
2000: K Nagashima; G W Cline; Gary W Mack; Gerald I Shulman; Ethan R Nadel
Intense exercise stimulates albumin synthesis in the upright posture.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;88(1):41-6.
1999: BM Jucker; N Barucci; Gerald I Shulman
Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle.
The American journal of physiology 1999;277(3 Pt 1):E505-12.
1999: Raymond R Russell; Raynald Bergeron; Gerald I Shulman; Lawrence H Young
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR.
The American journal of physiology 1999;277(2 Pt 2):H643-9.
1999: Gary W Cline; Kitt Falk Petersen; Martin Krssak; Jun Shen; Ripudaman S Hundal; Zlatko Trajanoski; Silvio E Inzucchi; A Dresner; Douglas L Rothman; Gerald I Shulman
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes.
The New England journal of medicine 1999;341(4):240-6.
1999: Gerald I Shulman
Cellular mechanisms of insulin resistance in humans.
The American journal of cardiology 1999;84(1A):3J-10J.
1999: Stephen Previs; Gary W Cline; Gerald I Shulman
A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo.
The American journal of physiology 1999;277(1 Pt 1):E154-60.
1999: Lawrence H Young; Raymond R Russell; R Yin; M J Caplan; J Ren; Raynald Bergeron; Gerald I Shulman; Albert J Sinusas
Regulation of myocardial glucose uptake and transport during ischemia and energetic stress.
The American journal of cardiology 1999;83(12A):25H-30H.
1999: M E Griffin; Melissa Marcucci; Gary W Cline; K Bell; N Barucci; D Lee; L J Goodyear; Edward W Kraegen; Morris F White; Gerald I Shulman
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Diabetes 1999;48(6):1270-4.
1999: Raynald Bergeron; Raymond R Russell; Lawrence H Young; Jian Ming Ren; Melissa Marcucci; A Lee; Gerald I Shulman
Effect of AMPK activation on muscle glucose metabolism in conscious rats.
The American journal of physiology 1999;276(5 Pt 1):E938-44.
1999: Monica A Borg; Walter Borg; William V Tamborlane; Michael Brines; Gerald I Shulman; Robert S Sherwin
Chronic hypoglycemia and diabetes impair counterregulation induced by localized 2-deoxy-glucose perfusion of the ventromedial hypothalamus in rats.
Diabetes 1999;48(3):584-7.
1999: Kitt Falk Petersen; Martin Krssak; V Navarro; Visvanathan Chandramouli; Ripudaman S Hundal; William C Schumann; Bernard R Landau; Gerald I Shulman
Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis.
The American journal of physiology 1999;276(3 Pt 1):E529-35.
1999: Michael Roden; Gerald I Shulman
Applications of NMR spectroscopy to study muscle glycogen metabolism in man.
Annual review of medicine 1999;50():277-90.
1999: Martin Krssak; K Falk Petersen; A Dresner; L DiPietro; SM Vogel; Douglas L Rothman; Michael Roden; Gerald I Shulman
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.
Diabetologia 1999;42(1):113-6.
1999: A Dresner; Didier Laurent; Melissa Marcucci; M E Griffin; Sylvie Dufour; Gary W Cline; Lori A Slezak; Dana Andersen; Ripudaman S Hundal; Douglas L Rothman; Kitt Falk Petersen; Gerald I Shulman
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity.
The Journal of clinical investigation 1999;103(2):253-9.
1999: BM Jucker; Gary W Cline; N Barucci; Gerald I Shulman
Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study.
Diabetes 1999;48(1):134-40.
1998: Raymond R Russell; R Yin; M J Caplan; Xiaoyue Hu; J Ren; Gerald I Shulman; Albert J Sinusas; Lawrence H Young
Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo.
Circulation 1998;98(20):2180-6.
1998: C Robinson; William V Tamborlane; David G Maggs; Staffan Enoksson; Robert S Sherwin; D Silver; Gerald I Shulman; Sonia Caprio
Effect of insulin on glycerol production in obese adolescents.
The American journal of physiology 1998;274(4 Pt 1):E737-43.
1998: Silvio E Inzucchi; David G Maggs; Geralyn Spollett; S L Page; Fran Rife; V Walton; Gerald I Shulman
Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.
The New England journal of medicine 1998;338(13):867-72.
1998: Kitt Falk Petersen; Didier Laurent; Douglas L Rothman; Gary W Cline; Gerald I Shulman
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.
The Journal of clinical investigation 1998;101(6):1203-9.
1998: Kitt Falk Petersen; R Hendler; T Price; G Perseghin; Douglas L Rothman; N Held; Joan Amatruda; Gerald I Shulman
13C/31P NMR studies on the mechanism of insulin resistance in obesity.
Diabetes 1998;47(3):381-6.
1998: DJ Withers; J S Gutierrez; HH Towery; Deborah J Burks; Jian Ming Ren; Stephen Previs; Y Zhang; Dolores Bernal; S Pons; Gerald I Shulman; Susan Bonner-Weir; Morris F White
Disruption of IRS-2 causes type 2 diabetes in mice.
Nature 1998;391(6670):900-4.
1998: Gary W Cline; BM Jucker; Zlatko Trajanoski; AJ Rennings; Gerald I Shulman
A novel 13C NMR method to assess intracellular glucose concentration in muscle, in vivo.
The American journal of physiology 1998;274(2 Pt 1):E381-9.
1998: David G Maggs; Thomas A Buchanan; Charles F Burant; Gary W Cline; B Gumbiner; W A Hsueh; Silvio E Inzucchi; D Kelley; J Nolan; J M Olefsky; Kenneth S Polonsky; D Silver; T R Valiquett; Gerald I Shulman
Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.
Annals of internal medicine 1998;128(3):176-85.
1998: Didier Laurent; Kitt Falk Petersen; Raymond R Russell; Gary W Cline; Gerald I Shulman
Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans.
The American journal of physiology 1998;274(1 Pt 1):E130-8.
1997: Kitt Falk Petersen; Ralph Jacob; AB West; Robert S Sherwin; Gerald I Shulman
Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis.
The American journal of physiology 1997;273(6 Pt 1):E1189-93.
1997: Raymond R Russell; Gary W Cline; Patrick H Guthrie; GW Goodwin; Gerald I Shulman; Heinrich Taegtmeyer
Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation.
The Journal of clinical investigation 1997;100(11):2892-9.
1997: BM Jucker; AJ Rennings; Gary W Cline; Kitt Falk Petersen; Gerald I Shulman
In vivo NMR investigation of intramuscular glucose metabolism in conscious rats.
The American journal of physiology 1997;273(1 Pt 1):E139-48.
1997: G Perseghin; S Ghosh; K Gerow; Gerald I Shulman
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.
Diabetes 1997;46(6):1001-9.
1997: Gary W Cline; I Magnusson; Douglas L Rothman; Kitt Falk Petersen; Didier Laurent; Gerald I Shulman
Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1997;99(9):2219-24.
1997: BM Jucker; AJ Rennings; Gary W Cline; Gerald I Shulman
13C and 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat.
The Journal of biological chemistry 1997;272(16):10464-73.
1997: Lawrence H Young; Y Renfu; R Russell; Xiaoyue Hu; M Caplan; J Ren; Gerald I Shulman; Albert J Sinusas
Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo.
Circulation 1997;95(2):415-22.
1997: Monica A Borg; Robert S Sherwin; Walter Borg; William V Tamborlane; Gerald I Shulman
Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.
The Journal of clinical investigation 1997;99(2):361-5.
1997: Ralph J Jacob; James Dziura; M B Medwick; P Leone; Sonia Caprio; M During; Gerald I Shulman; Robert S Sherwin
The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus.
Diabetes 1997;46(1):150-2.
1996: Ralph J Jacob; James Dziura; J P Morgen; Gerald I Shulman; Robert S Sherwin
Time course of the defective alpha-cell response to hypoglycemia in diabetic BB rats.
Metabolism: clinical and experimental 1996;45(11):1422-6.
1996: G Perseghin; Thomas B Price; Kitt Falk Petersen; Michael Roden; Gary W Cline; K Gerow; Douglas L Rothman; Gerald I Shulman
Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects.
The New England journal of medicine 1996;335(18):1357-62.
1996: Gilberto Velho; Kitt Falk Petersen; G Perseghin; J H Hwang; Douglas L Rothman; M E Pueyo; Gary W Cline; philippe froguel; Gerald I Shulman
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
The Journal of clinical investigation 1996;98(8):1755-61.
1996: Kitt Falk Petersen; A B West; Adrian Reuben; Douglas L Rothman; Gerald I Shulman
Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy.
Hepatology (Baltimore, Md.) 1996;24(1):114-7.
1996: P H McNulty; Albert J Sinusas; C Q Shi; Donald P Dione; Lawrence H Young; G C Cline; Gerald I Shulman
Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia.
The Journal of clinical investigation 1996;98(1):62-9.
1996: Michael Roden; Thomas B Price; G Perseghin; Kitt Falk Petersen; Douglas L Rothman; Gary W Cline; Gerald I Shulman
Mechanism of free fatty acid-induced insulin resistance in humans.
The Journal of clinical investigation 1996;97(12):2859-65.
1996: Thomas B Price; G Perseghin; Antoni J Duleba; W Chen; J Chase; Douglas L Rothman; Robert G Shulman; Gerald I Shulman
NMR studies of muscle glycogen synthesis in insulin-resistant offspring of parents with non-insulin-dependent diabetes mellitus immediately after glycogen-depleting exercise.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5329-34.
1996: Michael Roden; G Perseghin; Kitt Falk Petersen; J H Hwang; Gary W Cline; K Gerow; Douglas L Rothman; Gerald I Shulman
The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans.
The Journal of clinical investigation 1996;97(3):642-8.
1996: Kitt Falk Petersen; T Price; Gary W Cline; Douglas L Rothman; Gerald I Shulman
Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period.
The American journal of physiology 1996;270(1 Pt 1):E186-91.
1996: R Taylor; I Magnusson; Douglas L Rothman; Gary W Cline; A Caumo; C Cobelli; Gerald I Shulman
Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.
The Journal of clinical investigation 1996;97(1):126-32.
1995: Gary W Cline; Gerald I Shulman
Mass and positional isotopomer analysis of glucose metabolism in periportal and pericentral hepatocytes.
The Journal of biological chemistry 1995;270(47):28062-7.
1995: Kitt Falk Petersen; J B Blair; Gerald I Shulman
Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver.
Metabolism: clinical and experimental 1995;44(11):1380-3.
1995: Walter S Zawalich; Kathleen C Zawalich; G G Kelley; Gerald I Shulman
Islet phosphoinositide hydrolysis and insulin secretory responses from prediabetic fa/fa ZDF rats.
Biochemical and biophysical research communications 1995;209(3):974-80.
1995: J H Hwang; G Perseghin; Douglas L Rothman; Gary W Cline; I Magnusson; Kitt Falk Petersen; Gerald I Shulman
Impaired net hepatic glycogen synthesis in insulin-dependent diabetic subjects during mixed meal ingestion. A 13C nuclear magnetic resonance spectroscopy study.
The Journal of clinical investigation 1995;95(2):783-7.
1995: I Magnusson; Douglas L Rothman; D P Gerard; Lee D Katz; Gerald I Shulman
Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration.
Diabetes 1995;44(2):185-9.
1995: Walter Borg; Robert S Sherwin; Matthew J During; Monica A Borg; Gerald I Shulman
Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release.
Diabetes 1995;44(2):180-4.
1994: Gary W Cline; Douglas L Rothman; I Magnusson; Lee D Katz; Gerald I Shulman
13C-nuclear magnetic resonance spectroscopy studies of hepatic glucose metabolism in normal subjects and subjects with insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1994;94(6):2369-76.
1994: R Gruetter; Edward J Novotny; Susan D Boulware; Graeme F Mason; Douglas L Rothman; Gerald I Shulman; J W Prichard; Robert G Shulman
Localized 13C NMR spectroscopy in the human brain of amino acid labeling from D-[1-13C]glucose.
Journal of neurochemistry 1994;63(4):1377-85.
1994: Kitt Falk Petersen; Gary W Cline; J B Blair; Gerald I Shulman
Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3'-5-triiodo-L-thyronine-treated rats.
The American journal of physiology 1994;267(2 Pt 1):E273-7.
1994: Thomas B Price; R Taylor; Graeme F Mason; Douglas L Rothman; Gerald I Shulman; Robert G Shulman
Turnover of human muscle glycogen with low-intensity exercise.
Medicine and science in sports and exercise 1994;26(8):983-91.
1994: R Gruetter; I Magnusson; Douglas L Rothman; M J Avison; Robert G Shulman; Gerald I Shulman
Validation of 13C NMR measurements of liver glycogen in vivo.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1994;31(6):583-8.
1994: Sonia Caprio; Gary W Cline; Susan D Boulware; C Permanente; Gerald I Shulman; Robert S Sherwin; William V Tamborlane
Effects of puberty and diabetes on metabolism of insulin-sensitive fuels.
The American journal of physiology 1994;266(6 Pt 1):E885-91.
1994: I Magnusson; Douglas L Rothman; BM Jucker; Gary W Cline; Robert G Shulman; Gerald I Shulman
Liver glycogen turnover in fed and fasted humans.
The American journal of physiology 1994;266(5 Pt 1):E796-803.
1994: Walter Borg; Matthew J During; Robert S Sherwin; Monica A Borg; Michael Brines; Gerald I Shulman
Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.
The Journal of clinical investigation 1994;93(4):1677-82.
1994: G Bloch; J R Chase; D B Meyer; M J Avison; Gerald I Shulman; Robert G Shulman
In vivo regulation of rat muscle glycogen resynthesis after intense exercise.
The American journal of physiology 1994;266(1 Pt 1):E85-91.
1994: Thomas B Price; Douglas L Rothman; R Taylor; M J Avison; Gerald I Shulman; Robert G Shulman
Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(1):104-11.
1993: G Rossi; Robert S Sherwin; Alan Penzias; P Lapaczewski; Ralph J Jacob; Gerald I Shulman; Michael Diamond
Temporal changes in insulin resistance and secretion in 24-h-fasted conscious pregnant rats.
The American journal of physiology 1993;265(6 Pt 1):E845-51.
1993: A M Powell; Robert S Sherwin; Gerald I Shulman
Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. Reversibility and stimulus specificity of the deficits.
The Journal of clinical investigation 1993;92(6):2667-74.
1993: G Rossi; P Lapaczewski; Michael Diamond; Ralph J Jacob; Gerald I Shulman; Robert S Sherwin
Inhibitory effect of pregnancy on counterregulatory hormone responses to hypoglycemia in awake rat.
Diabetes 1993;42(10):1440-5.
1993: R Taylor; Thomas B Price; Lee D Katz; Robert G Shulman; Gerald I Shulman
Direct measurement of change in muscle glycogen concentration after a mixed meal in normal subjects.
The American journal of physiology 1993;265(2 Pt 1):E224-9.
1993: R Gruetter; Edward J Novotny; Susan D Boulware; Douglas L Rothman; Graeme F Mason; Gerald I Shulman; William V Tamborlane; Robert G Shulman
Non-invasive measurements of the cerebral steady-state glucose concentration and transport in humans by 13C nuclear magnetic resonance.
Advances in experimental medicine and biology 1993;331():35-40.
1993: Gary W Cline; K Greenawalt; Gerald I Shulman
Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo.
Acta diabetologica 1993;30(2):70-2.
1992: Ognen A C Petroff; Edward J Novotny; M Avison; Douglas L Rothman; J R Alger; T Ogino; Gerald I Shulman; J W Prichard
Cerebral lactate turnover after electroshock: in vivo measurements by 1H/13C magnetic resonance spectroscopy.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(6):1022-9.
1992: Douglas L Rothman; Edward J Novotny; Gerald I Shulman; AM Howseman; Ognen A C Petroff; G Mason; T Nixon; Christopher C Hanstock; J W Prichard; Robert G Shulman
1H-[13C] NMR measurements of [4-13C]glutamate turnover in human brain.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(20):9603-6.
1992: Gerald I Shulman; Bernard R Landau
Pathways of glycogen repletion.
Physiological reviews 1992;72(4):1019-35.
1992: I Magnusson; Douglas L Rothman; Lee D Katz; Robert G Shulman; Gerald I Shulman
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.
The Journal of clinical investigation 1992;90(4):1323-7.
1992: S Ganesan; R Calle; Kathleen C Zawalich; K Greenawalt; Walter S Zawalich; Gerald I Shulman; Howard Rasmussen
Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion.
The Journal of cell biology 1992;119(2):313-24.
1992: R Gruetter; Douglas L Rothman; Edward J Novotny; Gerald I Shulman; J W Prichard; Robert G Shulman
Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1992;27(1):183-8.
1992: R Taylor; Thomas B Price; Douglas L Rothman; Robert G Shulman; Gerald I Shulman
Validation of 13C NMR measurement of human skeletal muscle glycogen by direct biochemical assay of needle biopsy samples.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1992;27(1):13-20.
1992: Ralph J Jacob; Robert S Sherwin; K Greenawalt; Gerald I Shulman
Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rats.
Diabetes 1992;41(6):691-7.
1992: Douglas L Rothman; Robert G Shulman; Gerald I Shulman
31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.
The Journal of clinical investigation 1992;89(4):1069-75.
1992: R Gruetter; Edward J Novotny; Susan D Boulware; Douglas L Rothman; Graeme F Mason; Gerald I Shulman; Robert G Shulman; William V Tamborlane
Direct measurement of brain glucose concentrations in humans by 13C NMR spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(3):1109-12.
1991: Douglas L Rothman; I Magnusson; Lee D Katz; Robert G Shulman; Gerald I Shulman
Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR.
Science (New York, N.Y.) 1991;254(5031):573-6.
1991: L Bowen; P P Stein; R Stevenson; Gerald I Shulman
The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats.
Metabolism: clinical and experimental 1991;40(10):1025-30.
1991: Douglas L Rothman; AM Howseman; G D Graham; Ognen A C Petroff; G Lantos; Pierre Fayad; L M Brass; Gerald I Shulman; Robert G Shulman; J W Prichard
Localized proton NMR observation of [3-13C]lactate in stroke after [1-13C]glucose infusion.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1991;21(2):302-7.
1991: I Magnusson; Gerald I Shulman
Pathways of hepatic glycogen synthesis in humans.
Medicine and science in sports and exercise 1991;23(8):939-43.
1991: Gerald I Shulman; Ralph DeFronzo; L Rossetti
Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion.
The American journal of physiology 1991;260(5 Pt 1):E731-5.
1991: Gary W Cline; Gerald I Shulman
Quantitative analysis of the pathways of glycogen repletion in periportal and perivenous hepatocytes in vivo.
The Journal of biological chemistry 1991;266(7):4094-8.
1990: Gerald I Shulman; Gary W Cline; William C Schumann; Visvanathan Chandramouli; K Kumaran; Bernard R Landau
Quantitative comparison of pathways of hepatic glycogen repletion in fed and fasted humans.
The American journal of physiology 1990;259(3 Pt 1):E335-41.
1990: Gerald I Shulman; Douglas L Rothman; Thomas Jue; P Stein; Ralph DeFronzo; R G Shulman
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.
The New England journal of medicine 1990;322(4):223-8.
1990: Walter S Zawalich; Kathleen C Zawalich; Gerald I Shulman; L Rossetti
Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets.
Endocrinology 1990;126(1):253-60.
1989: Gerald I Shulman; L Rossetti
Influence of the route of glucose administration on hepatic glycogen repletion.
The American journal of physiology 1989;257(5 Pt 1):E681-5.
1989: L Rossetti; Douglas L Rothman; Ralph DeFronzo; Gerald I Shulman
Effect of dietary protein on in vivo insulin action and liver glycogen repletion.
The American journal of physiology 1989;257(2 Pt 1):E212-9.
1989: Thomas Jue; Douglas L Rothman; Gerald I Shulman; B A Tavitian; Ralph DeFronzo; Robert G Shulman
Direct observation of glycogen synthesis in human muscle with 13C NMR.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4489-91.
1988: Gerald I Shulman; Douglas L Rothman; Youngran Chung; L Rossetti; W A Petit; Eugene J Barrett; Robert G Shulman
13C NMR studies of glycogen turnover in the perfused rat liver.
The Journal of biological chemistry 1988;263(11):5027-9.
1987: L Rossetti; Gerald I Shulman; W Zawalich; Ralph DeFronzo
Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.
The Journal of clinical investigation 1987;80(4):1037-44.
1987: L Rossetti; Gerald I Shulman; Walter S Zawalich
Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding.
Diabetes 1987;36(10):1212-5.