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Leonard Shultz

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Yoriko Saito; Mikako Shirouzu; Leonard D Shultz; Akiko Sone; Nahoko Suzuki; Shinsuke Takagi; Akiko Tanaka; Satoshi Tanaka; Shuichi Taniguchi; Yuri Tomabechi; Mariko Tomizawa-Murasawa; Naoyuki Uchida; Motoaki Wakiyama; Shigeyuki Yokoyama; Hitomi Yuki; Yuki Aoki; Takehiro Fukami; Toshio Goto; Noriko Handa; Yoshinobu Hashizume; Teruki Honma; Hiroshi Kajita; Akiko Kaneko; Mitsuo Kuratani; Junko Mikuni; Yuho Najima; Ikuko Ogahara; Osamu Ohara; Fumihiko Ishikawa
A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Hira Lal Goel; Dale L Greiner; Prashant Kumar; Charlotte Kuperwasser; Junhao Mao; Jens Henrik Norum; Bryan Pursell; Leslie M Shaw; Leonard D Shultz; Karl Simin; Rune Toftgard; Craig W Vander Kooi; Cheng Chang; Arthur M Mercurio
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.
Rosemarie Seymour; Bobbi-Jo Shirley; Leonard D Shultz; Harm Hogenesch; John P Sundberg
Loss of function of the mouse Sharpin gene results in Peyer's patch regression.

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2013: Yoriko Saito; Mikako Shirouzu; Leonard D Shultz; Akiko Sone; Nahoko Suzuki; Shinsuke Takagi; Akiko Tanaka; Satoshi Tanaka; Shuichi Taniguchi; Yuri Tomabechi; Mariko Tomizawa-Murasawa; Naoyuki Uchida; Motoaki Wakiyama; Shigeyuki Yokoyama; Hitomi Yuki; Yuki Aoki; Takehiro Fukami; Toshio Goto; Noriko Handa; Yoshinobu Hashizume; Teruki Honma; Hiroshi Kajita; Akiko Kaneko; Mitsuo Kuratani; Junko Mikuni; Yuho Najima; Ikuko Ogahara; Osamu Ohara; Fumihiko Ishikawa
A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Science translational medicine 2013;5(181):181ra52.
2013: Hira Lal Goel; Dale L Greiner; Prashant Kumar; Charlotte Kuperwasser; Junhao Mao; Jens Henrik Norum; Bryan Pursell; Leslie M Shaw; Leonard D Shultz; Karl Simin; Rune Toftgard; Craig W Vander Kooi; Cheng Chang; Arthur M Mercurio
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation.
EMBO molecular medicine 2013;5(4):488-508.
2013: Rosemarie Seymour; Bobbi-Jo Shirley; Leonard D Shultz; Harm Hogenesch; John P Sundberg
Loss of function of the mouse Sharpin gene results in Peyer's patch regression.
PloS one 2013;8(2):e55224.
2013: Vishnu Hosur; Kenneth R Johnson; Anoop Kavirayani; Bonnie L Lyons; Kimberly A Martin; Rebecca L Riding; Lynn Alley; Lisa M Burzenski; Gregory A Cox; Melissa L Cox; Leonard D Shultz
Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice.
PloS one 2013;8(1):e53426.
2012: Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
Humanized mice for immune system investigation: progress, promise and challenges.
Nature reviews. Immunology 2012;12(11):786-98.
2012: Smita Jaiswal; Michael A Brehm; Dale L Greiner; Pamela Pazoles; Leonard D Shultz; Marcia Woda; Anuja Mathew
Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Immunology 2012;136(3):334-43.
2012: Guozheng Liu; Mary Rusckowski; Leonard D Shultz; Philip R Streeter; Ali Akalin; Shuping Dou; Dale L Greiner
Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Nuclear medicine and biology 2012;39(5):645-51.
2012: Vishnu Hosur; Anoop Kavirayani; Bonnie Lyons; Jennifer Riefler; Lisa M B Carney; Gregory A Cox; Bruce Gott; Leonard D Shultz
Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma.
Cancer genetics 2012;205(5):232-41.
2012: Michael A Brehm; Alvin C Powers; Leonard D Shultz; Dale L Greiner
Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Cold Spring Harbor perspectives in medicine 2012;2(5):a007757.
2012: Michael A Brehm; Leonard D Shultz
Human allograft rejection in humanized mice: a historical perspective.
Cellular & molecular immunology 2012;9(3):225-31.
2012: Michael A Brehm; Lisa M Burzenski; Raymond Dunn; Bruce Gott; Mary Herlihy; Vishnu Hosur; Ronald Ignotz; Jean Leif; Waldemar J Racki; Leonard D Shultz; Amber Wetmore; Dale L Greiner
Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.
Blood 2012;119(12):2778-88.
2011: Guozheng Liu; Shuping Dou; Dengfeng Cheng; Jean Leif; Mary Rusckowski; Philip R Streeter; Leonard D Shultz; Donald J Hnatowich; Dale L Greiner
Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Molecular pharmaceutics 2011;8(3):767-73.
2011: Lihong Zhao; Stefka D Spassieva; Thomas J Jucius; Leonard D Shultz; H Elizabeth Shick; Wendy B Macklin; Yusuf A Hannun; Lina M Obeid; Susan L Ackerman
A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
PLoS genetics 2011;7(5):e1002063.
2010: Leonard D Shultz; Yoriko Saito; Yuho Najima; Satoshi Tanaka; Toshiki Ochi; Mariko Tomizawa; Takehiko Doi; Akiko Sone; Nahoko Suzuki; Hiroshi Fujiwara; Masaki Yasukawa; Fumihiko Ishikawa
Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(29):13022-7.
2010: Michael A Brehm; Leonard D Shultz; Dale L Greiner
Humanized mouse models to study human diseases.
Current opinion in endocrinology, diabetes, and obesity 2010;17(2):120-5.
2010: Michael A Brehm; Amy Cuthbert; Chaoxing Yang; David M Miller; Philip DiIorio; Joseph Laning; Lisa M Burzenski; Bruce Gott; Oded Foreman; Anoop Kavirayani; Mary Herlihy; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Clinical immunology (Orlando, Fla.) 2010;135(1):84-98.
2010: Waldemar J Racki; Laurence Covassin; Michael Brehm; Stephen Pino; Ronald Ignotz; Raymond Dunn; Joseph Laning; Susannah K Graves; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Transplantation 2010;89(5):527-36.
2010: Thomas H Chase; Bonnie L Lyons; Roderick T Bronson; Oded Foreman; Leah Rae Donahue; Lisa M Burzenski; Bruce Gott; Priscilla Lane; Belinda Harris; Uta Ceglarek; Joachim Thiery; Henning Wittenburg; Jonathan N Thon; Joseph E Italiano; Kenneth R Johnson; Leonard D Shultz
The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.
Blood 2010;115(6):1267-76.
2010: Steve Pino; Michael A Brehm; Laurence Covassin-Barberis; Marie King; Bruce Gott; Thomas H Chase; Jennifer Wagner; Lisa M Burzenski; Oded Foreman; Dale L Greiner; Leonard D Shultz
Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Methods in molecular biology (Clifton, N.J.) 2010;602():105-17.
2009: Thomas H Chase; Gregory A Cox; Lisa M Burzenski; Oded Foreman; Leonard D Shultz
Dysferlin deficiency and the development of cardiomyopathy in a mouse model of limb-girdle muscular dystrophy 2B.
The American journal of pathology 2009;175(6):2299-308.
2009: Jacqueline Unsinger; Jacquelyn S McDonough; Leonard D Shultz; Thomas A Ferguson; Richard S Hotchkiss
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Journal of leukocyte biology 2009;86(2):219-27.
2009: M A King; L Covassin; M A Brehm; W Racki; Todd Pearson; Jean Leif; J Laning; W Fodor; O Foreman; Lisa M Burzenski; T H Chase; Bruce Gott; Aldo A Rossini; R Bortell; Leonard D Shultz; Dale L Greiner
Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Clinical and experimental immunology 2009;157(1):104-18.
2009: Prerna Chopra; Philip Diiorio; Steven C Pino; S Brian Wilson; Nancy E Phillips; John P Mordes; Aldo A Rossini; Dale L Greiner; Leonard D Shultz; Rita Bortell
Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
In vivo (Athens, Greece) 2009;23(2):195-201.
2009: Smita Jaiswal; Todd Pearson; Heather Friberg; Leonard D Shultz; Dale L Greiner; Alan L Rothman; Anuja Mathew
Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
PloS one 2009;4(10):e7251.
2009: Julie Mangada; Todd Pearson; Michael A Brehm; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; David V Serreze; Aldo A Rossini; Dale L Greiner
Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Diabetes 2009;58(1):165-73.
2008: Marie King; Todd Pearson; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
Humanized mice for the study of type 1 diabetes and beta cell function.
Annals of the New York Academy of Sciences 2008;1150():46-53.
2008: Todd Pearson; Leonard D Shultz; D Miller; M King; J Laning; W Fodor; A Cuthbert; Lisa M Burzenski; Bruce Gott; B Lyons; O Foreman; Aldo A Rossini; Dale L Greiner
Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Clinical and experimental immunology 2008;154(2):270-84.
2008: Lisa J Giassi; Todd Pearson; Leonard D Shultz; Joseph Laning; Kristin Biber; Morey Kraus; Bruce A Woda; Madelyn R Schmidt; Robert T Woodland; Aldo A Rossini; Dale L Greiner
Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Experimental biology and medicine (Maywood, N.J.) 2008;233(8):997-1012.
2008: Todd Pearson; Leonard D Shultz; J Lief; Lisa M Burzenski; Bruce Gott; T Chase; O Foreman; Aldo A Rossini; R Bottino; Massimo Trucco; Dale L Greiner
A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Diabetologia 2008;51(8):1449-56.
2008: Todd Pearson; Dale L Greiner; Leonard D Shultz
Creation of "humanized" mice to study human immunity.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2008;Chapter 15():Unit 15.21.
2008: Marie King; Todd Pearson; Leonard D Shultz; Jean Leif; Rita Bottino; Massimo Trucco; Mark A Atkinson; clive wasserfall; Kevan C Herold; Robert T Woodland; Madelyn R Schmidt; Bruce A Woda; Michael J Thompson; Aldo A Rossini; Dale L Greiner
A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Clinical immunology (Orlando, Fla.) 2008;126(3):303-14.
2008: Madelyn R Schmidt; Michael C Appel; Lisa J Giassi; Dale L Greiner; Leonard D Shultz; Robert T Woodland
Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
PloS one 2008;3(9):e3192.
2008: Todd Pearson; Dale L Greiner; Leonard D Shultz
Humanized SCID mouse models for biomedical research.
Current topics in microbiology and immunology 2008;324():25-51.
2007: Thomas B Thornley; Nancy E Phillips; Britte C Beaudette-Zlatanova; Thomas G Markees; Kapil Bahl; Michael A Brehm; Leonard D Shultz; Evelyn A Kurt-Jones; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(10):6620-9.
2007: M Yamazaki; Todd Pearson; Michael A Brehm; D M Miller; Julie Mangada; Thomas G Markees; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(7):1710-21.
2007: R E Seymour; Muneer G Hasham; Gregory A Cox; Leonard D Shultz; H Hogenesch; D C Roopenian; John P Sundberg
Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.
Genes and immunity 2007;8(5):416-21.
2007: Marie King; Todd Pearson; Leonard D Shultz; Jean Leif; Rita Bottino; Massimo Trucco; Mark Atkinson; clive wasserfall; Kevan Herold; John P Mordes; Aldo A Rossini; Dale L Greiner
Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Annals of the New York Academy of Sciences 2007;1103():90-3.
2007: Leonard D Shultz; Todd Pearson; Marie King; Lisa Giassi; Lisa Carney; Bruce Gott; Bonnie Lyons; Aldo A Rossini; Dale L Greiner
Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Annals of the New York Academy of Sciences 2007;1103():77-89.
2007: Leonard D Shultz; Fumihiko Ishikawa; Dale L Greiner
Humanized mice in translational biomedical research.
Nature reviews. Immunology 2007;7(2):118-30.
2006: Hideyuki Masaki; Michael C Appel; Linda Leahy; Jean Leif; Linda Paquin; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Xenotransplantation 2006;13(3):224-32.
2006: Bonnie L Lyons; Richard S Smith; Ronald E Hurd; Norman L Hawes; Lisa M Burzenski; Steven Nusinowitz; Muneer G Hasham; Bo Chang; Leonard D Shultz
Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.
Investigative ophthalmology & visual science 2006;47(3):1201-9.
2006: Christian Taube; Nobuaki Miyahara; Vanessa L Ott; Brad Swanson; Katsuyuki Takeda; Joan E Loader; Leonard D Shultz; Andrew M Tager; Andrew D Luster; Azzeddine Dakhama; Erwin W Gelfand
The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3157-64.
2006: Thomas B Thornley; Michael A Brehm; Thomas G Markees; Leonard D Shultz; John P Mordes; Raymond M Welsh; Aldo A Rossini; Dale L Greiner
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1561-70.
2006: Igor Mikaelian; M Hovick; Kathleen A Silva; Lisa M Burzenski; Leonard D Shultz; Cheryl L Ackert-Bicknell; Gregory A Cox; John P Sundberg
Expression of terminal differentiation proteins defines stages of mouse mammary gland development.
Veterinary pathology 2006;43(1):36-49.
2005: Motonobu Ueno; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Daniel Shaffer; Derry C Roopenian; Leonard D Shultz
Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature.
Investigative ophthalmology & visual science 2005;46(11):4097-106.
2005: Il-Kyoo Park; Leonard D Shultz; John J Letterio; James D Gorham
TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5666-74.
2005: Cynthia Helms; Stephen Pelsue; Li Cao; Erika Lamb; Brett Loffredo; Patricia Taillon-Miller; Brooke Herrin; Lisa M Burzenski; Bruce Gott; Bonnie L Lyons; Deana Keppler; Leonard D Shultz; Anne M Bowcock
The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.
Experimental biology and medicine (Maywood, N.J.) 2005;230(9):659-67.
2005: Leonard D Shultz; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Xiaohua Chen; Stanley Chaleff; Malak Kotb; Stephen D Gillies; Marie King; Julie Mangada; Dale L Greiner; Rupert Handgretinger
Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(10):6477-89.
2005: Anja Jaeschke; Mercedes Rincón; Beth Doran; Judy Reilly; Donna Neuberg; Dale L Greiner; Leonard D Shultz; Aldo A Rossini; Richard A Flavell; Roger J Davis
Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(19):6931-5.
2005: Ethel J Gordon; Linda S Wicker; Laurence B Peterson; David V Serreze; Thomas G Markees; Leonard D Shultz; Aldo A Rossini; Dale L Greiner; John P Mordes
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Diabetes 2005;54(1):107-15.
2004: Thomas G Markees; Todd Pearson; Amy Cuthbert; Andrea L Pearson; Leonard D Shultz; Jean Leif; Nancy E Phillips; John P Mordes; Dale L Greiner; Aldo A Rossini
Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Transplantation 2004;78(11):1601-8.
2004: Scott J Banuelos; Thomas G Markees; Nancy E Phillips; Michael C Appel; Amy Cuthbert; Jean Leif; John P Mordes; Leonard D Shultz; Aldo A Rossini; Dale L Greiner
Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Transplantation 2004;78(5):660-7.
2004: Scott J Banuelos; Leonard D Shultz; Dale L Greiner; Lisa M Burzenski; Bruce Gott; Bonnie L Lyons; Aldo A Rossini; Michael C Appel
Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Clinical immunology (Orlando, Fla.) 2004;112(3):273-83.
2004: Todd Pearson; Peter Weiser; Thomas G Markees; David V Serreze; Linda S Wicker; Laurence B Peterson; Anne-Marie Cumisky; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Diabetes 2004;53(8):1972-8.
2004: Michael C Appel; Scott J Banuelos; Dale L Greiner; Leonard D Shultz; John P Mordes; Aldo A Rossini
Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Transplantation 2004;77(9):1341-9.
2004: Christian Taube; Xudong Wei; Christina H Swasey; Anthony Joetham; Simona Zarini; Tricia Lively; Katsuyuki Takeda; Joan E Loader; Nobuaki Miyahara; Taku Kodama; Leonard D Shultz; Debra D Donaldson; Eckard H Hamelmann; Azzeddine Dakhama; Erwin W Gelfand
Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6398-406.
2004: Jung-Won Park; Christian Taube; Anthony Joetham; Katsuyuki Takeda; Taku Kodama; Azzeddine Dakhama; Glen McConville; Corrie B Allen; Georgia Sfyroera; Leonard D Shultz; John D Lambris; Patricia C Giclas; V Michael Holers; Erwin W Gelfand
Complement activation is critical to airway hyperresponsiveness after acute ozone exposure.
American journal of respiratory and critical care medicine 2004;169(6):726-32.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Annals of the New York Academy of Sciences 2003;1005():148-56.
2003: Leonard D Shultz; Scott J Banuelos; Bonnie Lyons; Rebecca Samuels; Lisa M Burzenski; Bruce Gott; Pamela Lang; Jean Leif; Michael C Appel; Aldo Rossini; Dale L Greiner
NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Transplantation 2003;76(7):1036-42.
2003: Nicole A Turgeon; Scott J Banuelos; Leonard D Shultz; Bonnie L Lyons; Neal Iwakoshi; Dale L Greiner; John P Mordes; Aldo A Rossini; Michael C Appel
Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Experimental biology and medicine (Maywood, N.J.) 2003;228(9):1096-104.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Reviews in endocrine & metabolic disorders 2003;4(3):255-61.
2003: Todd Pearson; Thomas G Markees; David V Serreze; Melissa A Pierce; Michele P Marron; Linda S Wicker; Laurence B Peterson; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(1):185-95.
2003: Leonard D Shultz; Scott J Banuelos; Jean Leif; Michael C Appel; Melody Cunningham; Karen K Ballen; Lisa M Burzenski; Dale L Greiner
Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Experimental hematology 2003;31(6):551-8.
2003: Bonnie L Lyons; Michael Lynes; Lisa M Burzenski; Melissa J Joliat; Nacima Hadjout; Leonard D Shultz
Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice.
Experimental hematology 2003;31(3):234-43.
2003: Kenneth R Johnson; Priscilla W Lane; Susan A Cook; Belinda S Harris; Patricia Ward-Bailey; Roderick T Bronson; Bonnie L Lyons; Leonard D Shultz; Muriel T Davisson
Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.
Genomics 2003;81(1):6-14.
2003: Leonard D Shultz; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Rebecca Samuels; Peter A Schweitzer; Christine K Dreger; Harald Herrmann; Vera Kalscheuer; Ada L Olins; Donald E Olins; Karl Sperling; Katrin Hoffmann
Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly.
Human molecular genetics 2003;12(1):61-9.
2002: Katrin Hoffmann; Christine K Dreger; Ada L Olins; Donald E Olins; Leonard D Shultz; Barbara Lucke; Hartmut Karl; Reinhard Kaps; Dietmar Müller; Amparo Vayá; Justo Aznar; Russell E Ware; Norberto Sotelo-Cruz; Tom H Lindner; Harald Herrmann; André Reis; Karl Sperling
Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Huët anomaly).
Nature genetics 2002;31(4):410-4.
2002: Melissa J Joliat; Syuji Umeda; Bonnie L Lyons; Michael Lynes; Leonard D Shultz
Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma.
In vivo (Athens, Greece) 2002;16(4):223-8.
2002: Sherri W Christianson; Dale L Greiner; Dominick DeLuca; Jean Leif; Nancy E Phillips; Sandra M Hayes; Shin-Ichi Hayashi; Melissa J Joliat; Bonnie L Lyons; Leonard D Shultz
T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Journal of autoimmunity 2002;18(2):119-30.
2002: Melissa J Joliat; Pamela A Lang; Bonnie L Lyons; Lisa M Burzenski; Michael Lynes; Taolin Yi; John P Sundberg; Leonard D Shultz
Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice.
Journal of autoimmunity 2002;18(2):105-17.
2001: Melissa J Joliat; Leonard D Shultz
The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases.
Clinical immunology (Orlando, Fla.) 2001;101(2):113-29.
2001: Catherine Duez; Adrian Tomkinson; Leonard D Shultz; Donna L Bratton; Erwin W Gelfand
Fas deficiency delays the resolution of airway hyperresponsiveness after allergen sensitization and challenge.
The Journal of allergy and clinical immunology 2001;108(4):547-56.
2001: Karen K Ballen; Helen M Valinski; Dale Greiner; Leonard D Shultz; Pamela S Becker; Chung-Cheng Hsieh; F Marc Stewart; Peter J Quesenberry
Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
British journal of haematology 2001;114(1):211-8.
2001: Ethel J Gordon; Bruce A Woda; Leonard D Shultz; Aldo A Rossini; Dale L Greiner; John P Mordes
Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
Transplantation 2001;71(2):319-27.
2000: Eckard H Hamelmann; Katsuyuki Takeda; Angela Haczku; Grzegorz Cieslewicz; Leonard D Shultz; Q Hamid; Zhou Xing; Jack Gauldie; Erwin W Gelfand
Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice.
American journal of respiratory cell and molecular biology 2000;23(3):327-34.
2000: J Schwarze; Grzegorz Cieslewicz; Anthony Joetham; Toshihide Ikemura; Mika J Mäkelä; Azzeddine Dakhama; Leonard D Shultz; M C Lamers; Erwin W Gelfand
Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization.
American journal of respiratory and critical care medicine 2000;162(2 Pt 1):380-6.
2000: EJ Wagar; M A Cromwell; Leonard D Shultz; Bruce A Woda; John L Sullivan; R M Hesselton; Dale L Greiner
Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):518-27.
2000: Orit Kollet; J G Moore; R Aviram; Herzl Ben-Hur; B L Liu; Arnon Nagler; Leonard D Shultz; M Feldman; Tsvee Lapidot
The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells.
Experimental hematology 2000;28(6):726-36.
2000: Orit Kollet; Amnon Peled; Tamara Byk; Herzl Ben-Hur; Dale Greiner; Leonard D Shultz; Tsvee Lapidot
beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Blood 2000;95(10):3102-5.
2000: Karen K Ballen; Pamela S Becker; Dale Greiner; Helen M Valinski; D Shearin; Virla Berrios; Gerri Dooner; Chung-Cheng Hsieh; Joanne Wuu; Leonard D Shultz; Jan Cerny; Jean Leif; F Marc Stewart; Peter J Quesenberry
Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
British journal of haematology 2000;108(3):629-40.
2000: Leonard D Shultz; P A Lang; Sherri W Christianson; Bruce Gott; Bonnie Lyons; S Umeda; Edward H Leiter; Ruth Hesselton; EJ Wagar; Jean Leif; Orit Kollet; Tsvee Lapidot; Dale L Greiner
NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(5):2496-507.
1999: Orit Kollet; R Aviram; Judith Chebath; Herzl Ben-Hur; Arnon Nagler; Leonard D Shultz; Michel Revel; Tsvee Lapidot
The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice.
Blood 1999;94(3):923-31.
1999: Thomas G Markees; David V Serreze; Nancy E Phillips; C H Sorli; Ethel J Gordon; Leonard D Shultz; RJ Noelle; Bruce A Woda; Dale L Greiner; John P Mordes; Aldo A Rossini
NOD mice have a generalized defect in their response to transplantation tolerance induction.
Diabetes 1999;48(5):967-74.
1999: J Schwarze; Grzegorz Cieslewicz; Eckard H Hamelmann; Anthony Joetham; Leonard D Shultz; M C Lamers; Erwin W Gelfand
IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(5):2997-3004.
1999: Amnon Peled; Isabelle Petit; Orit Kollet; M Magid; Tanya Ponomaryov; Tamara Byk; Arnon Nagler; Herzl Ben-Hur; A Many; Leonard D Shultz; Ofer Lider; Ronen Alon; Dov Zipori; Tsvee Lapidot
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Science (New York, N.Y.) 1999;283(5403):845-8.
1998: Ethel J Gordon; Thomas G Markees; Nancy E Phillips; RJ Noelle; Leonard D Shultz; John P Mordes; Aldo A Rossini; Dale L Greiner
Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Diabetes 1998;47(8):1199-206.
1998: Thomas G Markees; Nancy E Phillips; Ethel J Gordon; RJ Noelle; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
The Journal of clinical investigation 1998;101(11):2446-55.
1998: S C Pelsue; P A Schweitzer; I B Schweitzer; Sherri W Christianson; Bruce Gott; John P Sundberg; W G Beamer; Leonard D Shultz
Lymphadenopathy, elevated serum IgE levels, autoimmunity, and mast cell accumulation in flaky skin mutant mice.
European journal of immunology 1998;28(4):1379-88.
1998: Dale L Greiner; Ruth Hesselton; Leonard D Shultz
SCID mouse models of human stem cell engraftment.
Stem cells (Dayton, Ohio) 1998;16(3):166-77.
1998: T M Foy; M McIlraith; SR Masters; J J Dunn; A A Rossini; Leonard D Shultz; Ruth Hesselton; EJ Wagar; P E Lipsky; Randolph J Noelle; Dale L Greiner
Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Cell transplantation 1998;7(1):25-35.
1997: Katsuyuki Takeda; Eckard H Hamelmann; Anthony Joetham; Leonard D Shultz; Gary L Larsen; Charles G Irvin; Erwin W Gelfand
Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice.
The Journal of experimental medicine 1997;186(3):449-54.
1997: Leonard D Shultz; T V Rajan; D L Greiner
Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Trends in biotechnology 1997;15(8):302-7.
1997: Thomas G Markees; Nancy E Phillips; RJ Noelle; Leonard D Shultz; John P Mordes; Dale L Greiner; Aldo A Rossini
Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Transplantation 1997;64(2):329-35.
1997: David V Serreze; Harold D Chapman; D S Varnum; I Gerling; Edward H Leiter; Leonard D Shultz
Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3978-86.
1997: Sherri W Christianson; Dale L Greiner; Ruth Hesselton; Jean Leif; EJ Wagar; I B Schweitzer; T V Rajan; Bruce Gott; Derry C Roopenian; Leonard D Shultz
Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3578-86.
1997: P Tapley; N K Shevde; P A Schweitzer; M Gallina; Sherri W Christianson; I L Lin; R B Stein; Leonard D Shultz; J Rosen; P Lamb
Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice.
Experimental hematology 1997;25(2):122-31.