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Song-Kun Shyue

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J Wei; J-F Zhao; Song-Kun Shyue; L-C Ching; Y R Kou; H-F Lee; T-S Lee
Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.
Diahn-Warng Perng; Song-Kun Shyue; Jen-Ying Wang; Tsung-Ming Chang; Chih-Chieh Lee; Tzong-Shyuan Lee; Shing-Hwa Lu; Yu Ru Kou
Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury.
Y-B Yu; T-M Chang; Y R Kou; Y-W Liao; Song-Kun Shyue; K-H Su; T-S Lee
Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke.

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2013: J Wei; J-F Zhao; Song-Kun Shyue; L-C Ching; Y R Kou; H-F Lee; T-S Lee
Essential role of transient receptor potential vanilloid type 1 in evodiamine-mediated protection against atherosclerosis.
Acta physiologica (Oxford, England) 2013;207(2):299-307.
2013: Diahn-Warng Perng; Song-Kun Shyue; Jen-Ying Wang; Tsung-Ming Chang; Chih-Chieh Lee; Tzong-Shyuan Lee; Shing-Hwa Lu; Yu Ru Kou
Inflammatory role of AMP-activated protein kinase signaling in an experimental model of toxic smoke inhalation injury.
Critical care medicine 2013;41(1):120-32.
2012: Y-B Yu; T-M Chang; Y R Kou; Y-W Liao; Song-Kun Shyue; K-H Su; T-S Lee
Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke.
Acta physiologica (Oxford, England) 2012;205(4):532-40.
2012: Kuo-Hui Su; Yuan-Bin Yu; Jin-Feng Zhao; Song-Kun Shyue; Li-Ching Cheng; Hsin-Han Hou; Yu Ru Kou; Tzong-Shyuan Lee
AMP-activated protein kinase mediates erythropoietin-induced activation of endothelial nitric oxide synthase.
Journal of cellular physiology 2012;227(8):3053-62.
2012: Jing-Feng Zhao; Song-Kun Shyue; Chien-Yu Chen; An-Na Chiang; Li-Chieh Ching; Yu-Chu Huang; Yu Ru Kou; Tzong-Shyuan Lee
Molecular mechanism of curcumin on the suppression of cholesterol accumulation in macrophage foam cells and atherosclerosis.
Molecular nutrition & food research 2012;56(5):691-701.
2012: Wen-Yu Pan; Steve R Roffler; Song-Kun Shyue; Chun-Chi Chen; Chia-Hui Lo; Ping-Yi Wu; Mi-Hua Tao
Cancer immunotherapy using a membrane-bound interleukin-12 with B7-1 transmembrane and cytoplasmic domains.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(5):927-37.
2012: Chien-Hong Chen; Y Eugene Chen; Winston T K Cheng; Fuliang Du; Chia-Chia Liu; Song-Kun Shyue; Hwa-Yun Su; Li-Ying Sung; Shinn Chih Wu; Wei-Fang Chang; Jie Xu
Spatial and temporal distribution of Oct-4 and acetylated H4K5 in rabbit embryos.
Reproductive biomedicine online 2012;24(4):433-42.
2012: Chien-Yu Chen; Yi-Ming Arthur Chen; Li-Chieh Ching; Yi-Jen Liao; Song-Kun Shyue; Chia-Yuan Tsou; Yuan-Bin Yu; Tzong-Shyuan Lee
Deficiency of glycine N-methyltransferase aggravates atherosclerosis in apolipoprotein E-null mice.
Molecular medicine (Cambridge, Mass.) 2012;18():744-52.
2011: Tzu-An Liu; Tang-Long Shen; Song-Kun Shyue; John Wang; Pei-Feng Chen; Shyh-Chang Chen; Chiun Hsu; Ya-Lin Hung; Yee-Jee Jan; Bor-Sheng Ko; Yen-Ming Lee; Shu-Man Liang; Jun-Yang Liou
Increased expression of 14-3-3β promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma.
The American journal of pathology 2011;179(6):2698-708.
2011: Kuo-Hui Su; Yuan-Bin Yu; Ching-Chian Pan; Song-Kun Shyue; Chien-Yu Chen; An-Na Chiang; Li-Chieh Ching; Yu Ru Kou; Tzong-Shyuan Lee
β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase.
Journal of cellular physiology 2011;226(12):3330-9.
2011: Chien-Yu Chen; An-Na Chiang; Li-Chieh Ching; Yu Ru Kou; Ching-Chian Pan; Song-Kun Shyue; Kuo-Hui Su; Yu-Lin Wu; Tzong-Shyuan Lee
Wogonin promotes cholesterol efflux by increasing protein phosphatase 2B-dependent dephosphorylation at ATP-binding cassette transporter-A1 in macrophages.
The Journal of nutritional biochemistry 2011;22(11):1015-21.
2011: Yun-Chih Hsieh; Shih-Lan Hsu; Chi-Ying F Huang; Yerra Koteswara Rao; Song-Kun Shyue; Jacqueline Whang-Peng; Yew-Min Tzeng
Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway.
Journal of agricultural and food chemistry 2011;59(20):10943-54.
2011: Li-Chieh Ching; Yu Ru Kou; Li-Ching Cheng; Ching-Chian Pan; Song-Kun Shyue; Kuo-Hui Su; Jeng Wei; Yuan-Bin Yu; Tzong-Shyuan Lee
Molecular mechanisms of activation of endothelial nitric oxide synthase mediated by transient receptor potential vanilloid type 1.
Cardiovascular research 2011;91(3):492-501.
2011: Da-Tian Bau; Chao-Hsiang Chang; Yueh-Sheng Chen; Song-Kun Shyue; Chia-Wen Tsai; Ru-Yin Tsai; Hwei-Chung Wang; Rou-Fen Wang; Chun-Hsu Yao; Chih-Yang Huang
Significant association of caveolin-1 genotypes with bladder cancer susceptibility in Taiwan.
The Chinese journal of physiology 2011;54(3):153-60.
2011: Gau-Jun Tang; Hsin-Yi Wang; Jen-Ying Wang; Chih-Chieh Lee; Hsu-Wen Tseng; Yuh-Lin Wu; Song-Kun Shyue; Tzong-Shyuan Lee; Yu Ru Kou
Novel role of AMP-activated protein kinase signaling in cigarette smoke induction of IL-8 in human lung epithelial cells and lung inflammation in mice.
Free radical biology & medicine 2011;50(11):1492-502.
2011: Da-Tian Bau; Ming-Hsui Tsai; Yung-An Tsou; Chung-Hsing Wang; Chia-Wen Tsai; Shung-Shung Sun; Chun-Hung Hua; Song-Kun Shyue; Ru-Yin Tsai
The association of Caveolin-1 genotypes with oral cancer susceptibility in Taiwan.
Annals of surgical oncology 2011;18(5):1431-8.
2011: Che-Feng Chang; Szu-Fu Chen; Tzong-Shyuan Lee; Hung-Fu Lee; Shu-Fen Chen; Song-Kun Shyue
Caveolin-1 deletion reduces early brain injury after experimental intracerebral hemorrhage.
The American journal of pathology 2011;178(4):1749-61.
2011: Chih-Yen Wang; Jen-Kun Chen; Yi-Ting Wu; May-Jywan Tsai; Song-Kun Shyue; Chung-Shi Yang; Shun-Fen Tzeng
Reduction in antioxidant enzyme expression and sustained inflammation enhance tissue damage in the subacute phase of spinal cord contusive injury.
Journal of biomedical science 2011;18():13.
2011: Li-Ching Cheng; Kuo-Hui Su; Yu Ru Kou; Song-Kun Shyue; Li-Chieh Ching; Yuan-Bin Yu; Yuh-Lin Wu; Ching-Chian Pan; Tzong-Shyuan Lee
α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1.
Free radical biology & medicine 2011;50(1):47-54.
2011: Tsung-Huang Tsai; Shu-Fen Chen; Tai-Yu Huang; Chun-Fu Tzeng; Ann-Shyn Chiang; Yu Ru Kou; Tzong-Shyuan Lee; Song-Kun Shyue
Impaired Cd14 and Cd36 expression, bacterial clearance, and Toll-like receptor 4-Myd88 signaling in caveolin-1-deleted macrophages and mice.
Shock (Augusta, Ga.) 2011;35(1):92-9.
2010: Jin-Yi Tsai; Kuo-Hui Su; Song-Kun Shyue; Yu Ru Kou; Yuan-Bin Yu; Sheng-Huang Hsiao; An-Na Chiang; Yuh-Lin Wu; Li-Chieh Ching; Tzong-Shyuan Lee
EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1.
Cardiovascular research 2010;88(3):415-23.
2010: Tzong-Shyuan Lee; Ching-Chian Pan; Chien-Chung Peng; Yu Ru Kou; Chien-Yu Chen; Li-Chieh Ching; Tsung-Huang Tsai; Shu-Fen Chen; Ping-Chiang Lyu; Song-Kun Shyue
Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages.
Journal of cellular biochemistry 2010;111(1):104-10.
2010: Mei-Due Yang; Ru-Yin Tsai; Chiu-Shong Liu; Chao-Hsiang Chang; Hwei-Chung Wang; Yung-An Tsou; Chung-Hsing Wang; Cheng-Chieh Lin; Song-Kun Shyue; Da-Tian Bau
Association of Caveolin-1 polymorphisms with colorectal cancer susceptibility in Taiwan.
World journal of gastrointestinal oncology 2010;2(8):326-31.
2010: Shu-Fen Chen; Jun-Yang Liou; Tai-Yu Huang; Yu-Sin Lin; Ai-Ling Yeh; Kabik Tam; Tsung-Huang Tsai; Kenneth K Wu; Song-Kun Shyue
Caveolin-1 facilitates cyclooxygenase-2 protein degradation.
Journal of cellular biochemistry 2010;109(2):356-62.
2010: Bor-Sheng Ko; Tzu-Ching Chang; Chien-Hung Chen; Chia-Chia Liu; Cheng-Chin Kuo; Chiun Hsu; Ying-Chun Shen; Tang-Long Shen; Vita M Golubovskaya; Chung-Che Chang; Song-Kun Shyue; Jun-Yang Liou
Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B.
Life sciences 2010;86(5-6):199-206.
2009: Kuo-Hui Su; Jin-Yi Tsai; Yu Ru Kou; An-Na Chiang; Sheng-Huang Hsiao; Yuh-Lin Wu; Hsin-Han Hou; Ching-Chian Pan; Song-Kun Shyue; Tzong-Shyuan Lee
Valsartan regulates the interaction of angiotensin II type 1 receptor and endothelial nitric oxide synthase via Src/PI3K/Akt signalling.
Cardiovascular research 2009;82(3):468-75.
2009: Jui-Sheng Wu; Wai-Mui Cheung; Yau-Sheng Tsai; Yi-Tong Chen; Wen-Hsuan Fong; Hsin-Da Tsai; Yu-Chang Chen; Jun-Yang Liou; Song-Kun Shyue; Jin-Jer Chen; Y Eugene Chen; Nobuyo Maeda; Kenneth K Wu; Teng-nan Lin
Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation.
Circulation 2009;119(8):1124-34.
2008: Chung-Shi Yang; Bo-Cheng Tzou; Yu-Peng Liu; May-Jywan Tsai; Song-Kun Shyue; Shun-Fen Tzeng
Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium.
Journal of cellular biochemistry 2008;103(3):825-34.
2008: Ruey-Yun Wang; Chia-Min Chung; Cathy S J Fann; Hsin-Chou Yang; Jaw-Wen Chen; Yuh-Shiun Jong; Yuh-Shan Jou; Huey-Ming Lo; Feng-Ming Ho; Chih-Sen Kang; Chien-Chung Chen; Huan-Cheng Chang; Song-Kun Shyue; Wen-Harn Pan
Genome-wide scan for quantitative ACE activity in Taiwan young-onset hypertension study.
Human heredity 2008;65(2):85-90.
2007: May-Jywan Tsai; ching-feng Weng; Song-Kun Shyue; Dann-Ying Liou; Chien-Hung Chen; Chuan-Wen Chiu; Tzu-Hsuan Yang; Hsu-An Pan; Roanna I-Hsin Liao; Huai-Sheng Kuo; Ming-Chao Huang; Wen-Cheng Huang; Barry Hoffer; Henrich Cheng
Dual effect of adenovirus-mediated transfer of BMP7 in mixed neuron-glial cultures: neuroprotection and cellular differentiation.
Journal of neuroscience research 2007;85(13):2950-9.
2007: Shing-Jong Lin; Song-Kun Shyue; Meng-Chun Shih; Ting-Hui Chu; Yung-Hsiang Chen; Hung-Hai Ku; Jaw-Wen Chen; Ka-Bik Tam; Yuh-Lien Chen
Superoxide dismutase and catalase inhibit oxidized low-density lipoprotein-induced human aortic smooth muscle cell proliferation: role of cell-cycle regulation, mitogen-activated protein kinases, and transcription factors.
Atherosclerosis 2007;190(1):124-34.
2006: Yao-Ching Fang; Jui-Sheng Wu; Jean-Ju Chen; Wai-Mui Cheung; Ping-Hui Tseng; Ka-Bik Tam; Song-Kun Shyue; Jin-Jer Chen; Teng-nan Lin
Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(4):491-501.
2006: Teng-nan Lin; Wai-Mui Cheung; Jui-Sheng Wu; Jean-Ju Chen; Heng Lin; Jin-Jer Chen; Jun-Yang Liou; Song-Kun Shyue; Kenneth K Wu
15d-prostaglandin J2 protects brain from ischemia-reperfusion injury.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):481-7.
2005: Li-Kai Tsai; Ming-Shiun Tsai; Song-Kun Shyue; Wuh-Liang Hwu; Hung Li
Adenoviral interneuronal transportation after retrograde gene transfer in mice.
Brain research. Molecular brain research 2005;142(2):151-5.
2005: Tzu-Ching Chang; Chung-Jen Huang; Kabik Tam; Su-Fen Chen; Kien Thiam Tan; Ming-Song Tsai; Teng-nan Lin; Song-Kun Shyue
Stabilization of hypoxia-inducible factor-1{alpha} by prostacyclin under prolonged hypoxia via reducing reactive oxygen species level in endothelial cells.
The Journal of biological chemistry 2005;280(44):36567-74.
2005: Yu-Ting Su; Huei-Ling Chang; Song-Kun Shyue; Shih-Lan Hsu
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
Biochemical pharmacology 2005;70(2):229-41.
2005: Jun-Yang Liou; Nena Aleksic; Shu-Fen Chen; Tsai-Jung Han; Song-Kun Shyue; Kenneth K Wu
Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance.
Experimental cell research 2005;306(1):75-84.
2005: May-Jywan Tsai; Song-Kun Shyue; ching-feng Weng; Ying Chung; Dann-Ying Liou; Chi-Ting Huang; Huai-Sheng Kuo; Meng-Jen Lee; Pei-Teh Chang; Ming-Chao Huang; Wen-Cheng Huang; K D Liou; Henrich Cheng
Effect of enhanced prostacyclin synthesis by adenovirus-mediated transfer on lipopolysaccharide stimulation in neuron-glia cultures.
Annals of the New York Academy of Sciences 2005;1042():338-48.
2005: Shing-Jong Lin; Song-Kun Shyue; Ya-Yun Hung; Yung-Hsiang Chen; Hung-Hai Ku; Jaw-Wen Chen; Ka-Bik Tam; Yuh-Lien Chen
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(2):334-40.
2004: Deh-Ming Chang; Song-Kun Shyue; Shao-Hsiang Liu; Yen-Teen Chen; Chiou-Yueh Yeh; Jenn-Haung Lai; Herng-Sheng Lee; Ann Chen
Dual biological functions of an interleukin-1 receptor antagonist-interleukin-10 fusion protein and its suppressive effects on joint inflammation.
Immunology 2004;112(4):643-50.
2004: Shih-Chieh Hung; Cheng-Yi Lu; Song-Kun Shyue; Hwa-Chang Liu; Larry Low-Tone Ho
Lineage differentiation-associated loss of adenoviral susceptibility and Coxsackie-adenovirus receptor expression in human mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2004;22(7):1321-9.
2004: Shing-Jong Lin; Song-Kun Shyue; Po-Len Liu; Yung-Hsiang Chen; Hung-Hai Ku; Jaw-Wen Chen; Ka-Bik Tam; Yuh-Lien Chen
Adenovirus-mediated overexpression of catalase attenuates oxLDL-induced apoptosis in human aortic endothelial cells via AP-1 and C-Jun N-terminal kinase/extracellular signal-regulated kinase mitogen-activated protein kinase pathways.
Journal of molecular and cellular cardiology 2004;36(1):129-39.
2003: Chuen-Lin Huang; Nai-Kuei Huang; Song-Kun Shyue; Yijuang Chern
Hydrogen peroxide induces loss of dopamine transporter activity: a calcium-dependent oxidative mechanism.
Journal of neurochemistry 2003;86(5):1247-59.
2002: Ning Yu; Feng-Chi Chen; Satoshi Ota; Lynn B Jorde; Pekka Pamilo; László Patthy; Michele Ramsay; Trefor Jenkins; Song-Kun Shyue; Wen-Hsiung Li
Larger genetic differences within africans than between Africans and Eurasians.
Genetics 2002;161(1):269-74.
2002: Heng Lin; Teng-nan Lin; Wai-Mui Cheung; Gau-Ming Nian; Ping-Hui Tseng; Shu-Fen Chen; Jean-Ju Chen; Song-Kun Shyue; Jun-Yang Liou; Cheng-Wen Wu; Kenneth K Wu
Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction.
Circulation 2002;105(16):1962-9.
2001: Shu-Hui Juan; Tzong-Shyuan Lee; K W Tseng; Jun-Yang Liou; Song-Kun Shyue; Kenneth K Wu; Lee-Young Chau
Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice.
Circulation 2001;104(13):1519-25.
2001: Jun-Yang Liou; Wu-Guo Deng; Derek W Gilroy; Song-Kun Shyue; Kenneth K Wu
Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts.
The Journal of biological chemistry 2001;276(37):34975-82.
2001: Song-Kun Shyue; May-Jywan Tsai; Jun-Yang Liou; J T Willerson; Kenneth K Wu
Selective augmentation of prostacyclin production by combined prostacyclin synthase and cyclooxygenase-1 gene transfer.
Circulation 2001;103(16):2090-5.
2000: Jun-Yang Liou; Song-Kun Shyue; May-Jywan Tsai; C L Chung; K Y Chu; Kenneth K Wu
Colocalization of prostacyclin synthase with prostaglandin H synthase-1 (PGHS-1) but not phorbol ester-induced PGHS-2 in cultured endothelial cells.
The Journal of biological chemistry 2000;275(20):15314-20.
1999: Wan-Wan Lin; B C Chen; Ya-Wen Hsu; C M Lee; Song-Kun Shyue
Modulation of inducible nitric oxide synthase induction by prostaglandin E2 in macrophages: distinct susceptibility in murine J774 and RAW 264.7 macrophages.
Prostaglandins & other lipid mediators 1999;58(2-4):87-101.
1997: Song-Kun Shyue; Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu
Prostacyclin synthase active sites. Identification by molecular modeling-guided site-directed mutagenesis.
The Journal of biological chemistry 1997;272(6):3657-62.