FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Lie-Fen Shyur

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Procedures

Phytotherapy

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Physiology

Cell Proliferation

Co-author Network

Publications

TOP 3
Chi-Chang Huang; Kun-Ju Lin; Ya-Wen Cheng; Chih-An Hsu; Sien-Sing Yang; Lie-Fen Shyur
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis.
Wei-Chun Liu; Je-Hsin Chen; Wen-Yih Jeng; Yu-Shiun Lin; Andrew H-J Wang; Lie-Fen Shyur
Engineering of dual-functional hybrid glucanases.
Sheng-Chung Chen; Chih-An Hsu; Yu-Chang Su; Andrew H-J Wang; Nai-Chen Wang; Yun-Syuan Wei; Tuan-Nan Wen; Po-Hung Wu; Lie-Fen Shyur
Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Lie-Fen Shyur (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Chi-Chang Huang; Kun-Ju Lin; Ya-Wen Cheng; Chih-An Hsu; Sien-Sing Yang; Lie-Fen Shyur
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis.
The Journal of nutritional biochemistry 2013;24(3):516-30.
2012: Wei-Chun Liu; Je-Hsin Chen; Wen-Yih Jeng; Yu-Shiun Lin; Andrew H-J Wang; Lie-Fen Shyur
Engineering of dual-functional hybrid glucanases.
Protein engineering, design & selection : PEDS 2012;25(11):771-80.
2012: Sheng-Chung Chen; Chih-An Hsu; Yu-Chang Su; Andrew H-J Wang; Nai-Chen Wang; Yun-Syuan Wei; Tuan-Nan Wen; Po-Hung Wu; Lie-Fen Shyur
Biochemical characterization of a novel laccase from the basidiomycete fungus Cerrena sp. WR1.
Protein engineering, design & selection : PEDS 2012;25(11):761-9.
2012: Shao-Wen Hung; Chi-Ming Liang; Lie-Fen Shyur; Tai-An Chen; Ching-Feng Chiu; Chiao-Li Chu; Chi-Chang Huang; Shu-Mei Liang
Recombinant viral protein VP1 suppresses HER-2 expression and migration/metastasis of breast cancer.
Breast cancer research and treatment 2012;136(1):89-105.
2012: Chih-An Hsu; Zhi-Bing Jiang; Yu-Chang Su; Tuan-Nan Wen; Chin-Wen Chen; Lie-Fen Shyur
Biological degradation of anthroquinone and azo dyes by a novel laccase from Lentinus sp.
Environmental science & technology 2012;46(9):5109-17.
2012: Wai-Leng Lee; Lie-Fen Shyur
Deoxyelephantopin impedes mammary adenocarcinoma cell motility by inhibiting calpain-mediated adhesion dynamics and inducing reactive oxygen species and aggresome formation.
Free radical biology & medicine 2012;52(8):1423-36.
2011: Chia-Chung Hou; Chi-Chang Huang; Lie-Fen Shyur
Echinacea alkamides prevent lipopolysaccharide/D-galactosamine-induced acute hepatic injury through JNK pathway-mediated HO-1 expression.
Journal of agricultural and food chemistry 2011;59(22):11966-74.
2011: Li-Chu Tsai; Ching-Hua Hsiao; Wen-Yan Liu; Li-Ming Yin; Lie-Fen Shyur
Structural basis for the inhibition of 1,3-1,4-β-D-glucanase by noncompetitive calcium ion and competitive Tris inhibitors.
Biochemical and biophysical research communications 2011;407(3):593-8.
2011: Lie-Fen Shyur; Chi-Chang Huang; Yu-Ying Hsu; Ya-Wen Cheng; Shiaw-Der Yang
A sesquiterpenol extract potently suppresses inflammation in macrophages and mice skin and prevents chronic liver damage in mice through JNK-dependent HO-1 expression.
Phytochemistry 2011;72(4-5):391-9.
2011: Pei-Fen Su; Sheng-Yang Wang; Shih-Hsiung Wu; Feng-Ling Yang; Kandan Aravindaram; Spencer Benson; Sunney I Chan; Chih-Chien Hsu; Wen-Ching Huang; Chin-Jin Li; Lie-Fen Shyur; Ning-Sun Yang
Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo.
Evidence-based complementary and alternative medicine : eCAM 2011;2011():731308.
2010: Lie-Fen Shyur; Shu-Hua Lee; Shang-Tzen Chang; Chiu-Ping Lo; Yueh-Hsiung Kuo; Sheng-Yang Wang
Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2010;18(1):16-24.
2010: Chia-Chung Hou; Chun-Houh Chen; Ning-Sun Yang; Yi-Ping Chen; Chiu-Ping Lo; Sheng-Yang Wang; Yin-Jing Tien; Pi-Wen Tsai; Lie-Fen Shyur
Comparative metabolomics approach coupled with cell- and gene-based assays for species classification and anti-inflammatory bioactivity validation of Echinacea plants.
The Journal of nutritional biochemistry 2010;21(11):1045-59.
2010: Je-Hsin Chen; Li-Chu Tsai; Hsiao-Chuan Huang; Lie-Fen Shyur
Structural and catalytic roles of amino acid residues located at substrate-binding pocket in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase.
Proteins 2010;78(13):2820-30.
2010: Chi-Chang Huang; Chiu-Ping Lo; Chih-Yang Chiu; Lie-Fen Shyur
Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice.
British journal of pharmacology 2010;159(4):856-71.
2010: Wai-Leng Lee; Tuan-Nan Wen; Jeng-Yuan Shiau; Lie-Fen Shyur
Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells.
Journal of proteome research 2010;9(1):237-53.
2009: Yu-Shiun Lin; Li-Chu Tsai; Shu-Hua Lee; Hanna S Yuan; Lie-Fen Shyur
Structural and catalytic roles of residues located in beta13 strand and the following beta-turn loop in Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase.
Biochimica et biophysica acta 2009;1790(4):231-9.
2008: Li-Chu Tsai; Hsiao-Chuan Huang; Ching-Hua Hsiao; Yuan-Neng Chiang; Lie-Fen Shyur; Yu-Shiun Lin; Shu-Hua Lee
Mutational and structural studies of the active-site residues in truncated Fibrobacter succinogenes1,3-1,4-beta-D-glucanase.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 12):1259-66.
2008: Li-Chu Tsai; Yi-Ning Chen; Lie-Fen Shyur
Structural modeling of glucanase-substrate complexes suggests a conserved tyrosine is involved in carbohydrate recognition in plant 1,3-1,4-beta-D-glucanases.
Journal of computer-aided molecular design 2008;22(12):915-23.
2008: Pei-Fen Su; Vanisree Staniforth; Chin-Jin Li; Chien-Yu Wang; Ming-Tsang Chiao; Sheng-Yang Wang; Lie-Fen Shyur; Ning-Sun Yang
Immunomodulatory effects of phytocompounds characterized by in vivo transgenic human GM-CSF promoter activity in skin tissues.
Journal of biomedical science 2008;15(6):813-22.
2008: Feng-Min Lin; Chin-Hsien Tsai; Yu-Chih Yang; Wei-Chun Tu; Li-Ru Chen; Yun-Sa Liang; Sheng-Yang Wang; Lie-Fen Shyur; Shih-Chang Chien; Tai-Lung Cha; Pei-Wen Hsiao
A novel diterpene suppresses CWR22Rv1 tumor growth in vivo through antiproliferation and proapoptosis.
Cancer research 2008;68(16):6634-42.
2008: Lie-Fen Shyur; Chi-Chang Huang; Chiu-Ping Lo; Chih-Yang Chiu; Yi-Ping Chen; Sheng-Yang Wang; Shang-Tzen Chang
Hepatoprotective phytocompounds from Cryptomeria japonica are potent modulators of inflammatory mediators.
Phytochemistry 2008;69(6):1348-58.
2008: Jyh-Horng Wu; Yu-Tang Tung; Shih-Chang Chien; Sheng-Yang Wang; Yueh-Hsiung Kuo; Lie-Fen Shyur; Shang-Tzen Chang
Effect of phytocompounds from the heartwood of Acacia confusa on inflammatory mediator production.
Journal of agricultural and food chemistry 2008;56(5):1567-73.
2008: Lie-Fen Shyur; Ning-Sun Yang
Metabolomics for phytomedicine research and drug development.
Current opinion in chemical biology 2008;12(1):66-71.
2008: Chien-Yu Wang; Vanisree Staniforth; Ming-Tsang Chiao; Chia-Chung Hou; Han-Ming Wu; Kuo-Chen Yeh; Chun-Houh Chen; Pei-Ing Hwang; Tuan-Nan Wen; Lie-Fen Shyur; Ning-Sun Yang
Genomics and proteomics of immune modulatory effects of a butanol fraction of echinacea purpurea in human dendritic cells.
BMC genomics 2008;9():479.
2007: Yu-Hsin Hsieh; Pei-Min Kuo; Shih-Chang Chien; Lie-Fen Shyur; Sheng-Yang Wang
Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2007;14(10):675-80.
2007: Chih-Chun Wen; Yueh-Hsiung Kuo; Jia-Tsrong Jan; Po-Huang Liang; Sheng-Yang Wang; Hong-Gi Liu; Ching-Kuo Lee; Shang-Tzen Chang; Chih-Jung Kuo; Shoei-Sheng Lee; Chia-Chung Hou; Pei-Wen Hsiao; Shih-Chang Chien; Lie-Fen Shyur; Ning-Sun Yang
Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.
Journal of medicinal chemistry 2007;50(17):4087-95.
2007: Chia-Chung Hou; Yi-Ping Chen; Jyh-Horng Wu; Chi-Chang Huang; Sheng-Yang Wang; Ning-Sun Yang; Lie-Fen Shyur
A galactolipid possesses novel cancer chemopreventive effects by suppressing inflammatory mediators and mouse B16 melanoma.
Cancer research 2007;67(14):6907-15.
2007: Shu-Lin Chang; Yi-Ming Chiang; Cicero Lee-Tian Chang; Hsu-Hua Yeh; Lie-Fen Shyur; Yueh-Hsiung Kuo; Tung-Kung Wu; Wen-Chin Yang
Flavonoids, centaurein and centaureidin, from Bidens pilosa, stimulate IFN-gamma expression.
Journal of ethnopharmacology 2007;112(2):232-6.
2007: Li-Wha Wu; Yi-Ming Chiang; Hsiao-Ching Chuang; Chiu-Ping Lo; Kai-Ying Yang; Sheng-Yang Wang; Lie-Fen Shyur
A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7.
Planta medica 2007;73(7):655-61.
2007: Yi-Ming Chiang; Cicero Lee-Tian Chang; Shu-Lin Chang; Wen-Chin Yang; Lie-Fen Shyur
Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
Journal of ethnopharmacology 2007;110(3):532-8.
2006: Chien-Yu Wang; Ming-Tsang Chiao; Po-Jen Yen; Wei-Chou Huang; Chia-Chung Hou; Shih-Chang Chien; Kuo-Chen Yeh; Wen-Ching Yang; Lie-Fen Shyur; Ning-Sun Yang
Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study.
Genomics 2006;88(6):801-8.
2005: Li-Chu Tsai; Lie-Fen Shyur; Yi-Sheng Cheng; Shu-Hua Lee
Crystal structure of truncated Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase in complex with beta-1,3-1,4-cellotriose.
Journal of molecular biology 2005;354(3):642-51.
2005: Yi-Ming Chiang; Chiu-Ping Lo; Yi-Ping Chen; Sheng-Yang Wang; Ning-Sun Yang; Yueh-Hsiung Kuo; Lie-Fen Shyur
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin.
British journal of pharmacology 2005;146(3):352-63.
2005: Jyh-Horng Wu; Yu-Tang Tung; Sheng-Yang Wang; Lie-Fen Shyur; Yueh-Hsiung Kuo; Shang-Tzen Chang
Phenolic antioxidants from the heartwood of Acacia confusa.
Journal of agricultural and food chemistry 2005;53(15):5917-21.
2005: Tuan-Nan Wen; Jui-Lin Chen; Shu-Hua Lee; Ning-Sun Yang; Lie-Fen Shyur
A truncated Fibrobacter succinogenes 1,3-1,4-beta-d-glucanase with improved enzymatic activity and thermotolerance.
Biochemistry 2005;44(25):9197-205.
2005: Cicero Lee-Tian Chang; Hui-Kai Kuo; Shu-Lin Chang; Yi-Ming Chiang; Tsung-Han Lee; Wen-Mein Wu; Lie-Fen Shyur; Wen-Chin Yang
The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated airway inflammation in mice.
Journal of biomedical science 2005;12(1):79-89.
2004: Yi-Ming Chiang; Da-Yung Chuang; Sheng-Yang Wang; Yueh-Hsiung Kuo; Pi-Wen Tsai; Lie-Fen Shyur
Metabolite profiling and chemopreventive bioactivity of plant extracts from Bidens pilosa.
Journal of ethnopharmacology 2004;95(2-3):409-19.
2004: Lie-Fen Shyur; Chih-Huai Chen; Chiu-Ping Lo; Sheng-Yang Wang; Pei-Ling Kang; Show-Jane Sun; C Allen Chang; Chi-Meng Tzeng; Ning-Sun Yang
Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus.
Journal of biomedical science 2004;11(6):928-39.
2004: Li-Wha Wu; Yi-Ming Chiang; Hsiao-Ching Chuang; Sheng-Yang Wang; Ga-Wen Yang; Ya-Huey Chen; Ling-Ya Lai; Lie-Fen Shyur
Polyacetylenes function as anti-angiogenic agents.
Pharmaceutical research 2004;21(11):2112-9.
2004: Shu-Lin Chang; Cicero Lee-Tian Chang; Yi-Ming Chiang; Rong-Hong Hsieh; Chii-Ruey Tzeng; Tung-Kung Wu; Huey-Kang Sytwu; Lie-Fen Shyur; Wen-Chin Yang
Polyacetylenic compounds and butanol fraction from Bidens pilosa can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice.
Planta medica 2004;70(11):1045-51.
2004: Ning-Sun Yang; Lie-Fen Shyur; Chih-Huai Chen; Sheng-Yang Wang; Chi-Meng Tzeng
Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in mcf-7 cells.
Journal of biomedical science 2004;11(3):418-22.
2004: Vanisree Staniforth; Sheng-Yang Wang; Lie-Fen Shyur; Ning-Sun Yang
Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.
The Journal of biological chemistry 2004;279(7):5877-85.
2003: Li-Chu Tsai; Lie-Fen Shyur; Shu-Hua Lee; Su-Shiang Lin; Hanna S Yuan
Crystal structure of a natural circularly permuted jellyroll protein: 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes.
Journal of molecular biology 2003;330(3):607-20.
2003: Sheng-Yang Wang; Hsing-Ning Chang; Kai-Ti Lin; Chiu-Ping Lo; Ning-Sun Yang; Lie-Fen Shyur
Antioxidant properties and phytochemical characteristics of extracts from Lactuca indica.
Journal of agricultural and food chemistry 2003;51(5):1506-12.
2002: Hsueh-Ling Cheng; Li-Chu Tsai; Su-Shiang Lin; Hanna S Yuan; Ning-Sun Yang; Shu-Hua Lee; Lie-Fen Shyur
Mutagenesis of Trp(54) and Trp(203) residues on Fibrobacter succinogenes 1,3-1,4-beta-D-glucanase significantly affects catalytic activities of the enzyme.
Biochemistry 2002;41(27):8759-66.
2002: Sheng-Yang Wang; Yueh-Hsiung Kuo; Hsing-Ning Chang; Pei-Ling Kang; Hsin-Sheng Tsay; Ku-Feng Lin; Ning-Sun Yang; Lie-Fen Shyur
Profiling and characterization antioxidant activities in Anoectochilus formosanus hayata.
Journal of agricultural and food chemistry 2002;50(7):1859-65.
2001: Li-Chu Tsai; Lie-Fen Shyur; Su-Shiang Lin; Hanna S Yuan
Crystallization and preliminary X-ray diffraction analysis of the 1,3-1,4-beta-D-glucanase from Fibrobacter succinogenes.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1303-6.
2001: Shang-Tzen Chang; Jyh-Horng Wu; Sheng-Yang Wang; Pei-Ling Kang; Ning-Sun Yang; Lie-Fen Shyur
Antioxidant activity of extracts from Acacia confusa bark and heartwood.
Journal of agricultural and food chemistry 2001;49(7):3420-4.
2001: J L Chen; L C Tsai; T N Wen; J B Tang; Hanna S Yuan; Lie-Fen Shyur
Directed mutagenesis of apecific active site residues on Fibrobacter succinogenes 1,3-1,4-beta -D-glucanase significantly affects catalysis and enzyme structural stability.
The Journal of biological chemistry 2001;276(21):17895-901.