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Carol Hopkins Sibley

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Mijeong Park; Sukhyeong Cho; Hosa Lee; Carol Hopkins Sibley; Hogun Rhie
Alternative thymidylate synthase, ThyX, involved in Corynebacterium glutamicum ATCC 13032 survival during stationary growth phase.
Toby Leslie; Marnie Briceño; Ismail Mayan; Nasir Mohammed; Eveline Klinkenberg; Carol Hopkins Sibley; Christopher J M Whitty; Mark Rowland
The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan.
Carol Hopkins Sibley; Philippe Guerin; Pascal Ringwald
Monitoring antimalarial resistance: launching a cooperative effort.

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2010: Mijeong Park; Sukhyeong Cho; Hosa Lee; Carol Hopkins Sibley; Hogun Rhie
Alternative thymidylate synthase, ThyX, involved in Corynebacterium glutamicum ATCC 13032 survival during stationary growth phase.
FEMS microbiology letters 2010;307(2):128-34.
2010: Toby Leslie; Marnie Briceño; Ismail Mayan; Nasir Mohammed; Eveline Klinkenberg; Carol Hopkins Sibley; Christopher J M Whitty; Mark Rowland
The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan.
PLoS medicine 2010;7(5):e1000283.
2010: Carol Hopkins Sibley; Philippe Guerin; Pascal Ringwald
Monitoring antimalarial resistance: launching a cooperative effort.
Trends in parasitology 2010;26(5):221-4.
2009: Vivian N Hawkins; Stephanie M Suzuki; Kanchana Rungsihirunrat; Hapuarachchige C Hapuarachchi; Amanda Maestre; Kesara Na-Bangchang; Carol Hopkins Sibley
Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase.
The American journal of tropical medicine and hygiene 2009;81(2):348-55.
2008: Laura K Certain; Marnie Briceño; Steven M Kiara; Alexis Nzila; William M Watkins; Carol Hopkins Sibley
Characteristics of Plasmodium falciparum dhfr haplotypes that confer pyrimethamine resistance, Kilifi, Kenya, 1987--2006.
The Journal of infectious diseases 2008;197(12):1743-51.
2008: Kanchana Rungsihirunrat; Carol Hopkins Sibley; Mathirut Mungthin; Kesara Na-Bangchang
Geographical distribution of amino acid mutations in Plasmodium vivax DHFR and DHPS from malaria endemic areas of Thailand.
The American journal of tropical medicine and hygiene 2008;78(3):462-7.
2008: Jonathan E Ulmer; Yap Boum; Christopher D Thouvenel; Hannu Myllykallio; Carol Hopkins Sibley
Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.
Journal of bacteriology 2008;190(6):2056-64.
2008: Vivian N Hawkins; Alyson Auliff; Surendra Kumar Prajapati; Kanchana Rungsihirunrat; Hapuarachchige C Hapuarachchi; Amanda Maestre; Michael T O'Neil; Qin Cheng; Hema Joshi; Kesara Na-Bangchang; Carol Hopkins Sibley
Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase.
Malaria journal 2008;7():72.
2008: Carol Hopkins Sibley; Karen I Barnes; William M Watkins; Christopher Plowe
A network to monitor antimalarial drug resistance: a plan for moving forward.
Trends in parasitology 2008;24(1):43-8.
2007: Conner I Sandefur; Jason M Wooden; Isaac K E Quaye; Worachart Sirawaraporn; Carol Hopkins Sibley
Pyrimethamine-resistant dihydrofolate reductase enzymes of Plasmodium falciparum are not enzymatically compromised in vitro.
Molecular and biochemical parasitology 2007;154(1):1-5.
2007: Kanchana Rungsihirunrat; Kesara Na-Bangchang; Vivian N Hawkins; Mathirut Mungthin; Carol Hopkins Sibley
Sensitivity to antifolates and genetic analysis of Plasmodium vivax isolates from Thailand.
The American journal of tropical medicine and hygiene 2007;76(6):1057-65.
2007: Vivian N Hawkins; Hema Joshi; Kanchana Rungsihirunrat; Kesara Na-Bangchang; Carol Hopkins Sibley
Antifolates can have a role in the treatment of Plasmodium vivax.
Trends in parasitology 2007;23(5):213-22.
2007: Laura K Certain; Carol Hopkins Sibley
Plasmodium falciparum: a novel method for analyzing haplotypes in mixed infections.
Experimental parasitology 2007;115(3):233-41.
2007: Karen I Barnes; Niklas Lindegardh; Olumide Ogundahunsi; Piero Olliaro; Christopher Plowe; Milijaona Randrianarivelojosia; Grace O Gbotosho; William M Watkins; Carol Hopkins Sibley; Nicholas J White
World Antimalarial Resistance Network (WARN) IV: clinical pharmacology.
Malaria journal 2007;6():122.
2007: Christopher Plowe; Cally Roper; John W Barnwell; Christian T Happi; Hema H Joshi; Wilfred Mbacham; Steven R Meshnick; Kefas Mugittu; Inbarani Naidoo; Ric Price; Robert W Shafer; Carol Hopkins Sibley; Colin J Sutherland; Peter Zimmerman; Philip J Rosenthal
World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.
Malaria journal 2007;6():121.
2007: David J Bacon; Ronan Jambou; Thierry Fandeur; Jacques Le Bras; Chansuda Wongsrichanalai; Mark M Fukuda; Pascal Ringwald; Carol Hopkins Sibley; Dennis E Kyle
World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility.
Malaria journal 2007;6():120.
2007: Ric Price; Grant Dorsey; Elizabeth A Ashley; Karen I Barnes; J Kevin Baird; Umberto D'Alessandro; Philippe Guerin; Miriam K Laufer; Inbarani Naidoo; François Nosten; Piero Olliaro; Christopher Plowe; Pascal Ringwald; Carol Hopkins Sibley; Kasia Stepniewska; Nicholas J White
World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugs.
Malaria journal 2007;6():119.
2007: Carol Hopkins Sibley; Karen I Barnes; Christopher Plowe
The rationale and plan for creating a World Antimalarial Resistance Network (WARN).
Malaria journal 2007;6():118.
2006: Amir Attaran; Karen I Barnes; Roger Bate; Fred Binka; Umberto D'Alessandro; Caterina Fanello; Laurie Garrett; Theonest K Mutabingwa; Donald Roberts; Carol Hopkins Sibley; Ambrose O Talisuna; Jean-Pierre Van geertruyden; William M Watkins
The World Bank: false financial and statistical accounts and medical malpractice in malaria treatment.
Lancet 2006;368(9531):247-52.
2006: Parthasrathy Sampathkumar; Stewart Turley; Carol Hopkins Sibley; Wim G J Hol
NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
Journal of molecular biology 2006;360(1):1-6.
2006: Carol Hopkins Sibley
Malaria historians: analyze your old slides!
Trends in parasitology 2006;22(6):243-4.
2006: Hapuarachchige C Hapuarachchi; M Y D Dayanath; K B A T Bandara; Sudusinghe Abeysundara; Wimaladharma Abeyewickreme; Nilanthi R de Silva; Sonia Y Hunt; Carol Hopkins Sibley
Point mutations in the dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum and resistance to sulfadoxine-pyrimethamine in Sri Lanka.
The American journal of tropical medicine and hygiene 2006;74(2):198-204.
2006: Carol Hopkins Sibley; Pascal Ringwald
A database of antimalarial drug resistance.
Malaria journal 2006;5():48.
2005: Patrick Duffy; Carol Hopkins Sibley
Are we losing artemisinin combination therapy already?
Lancet 2005;366(9501):1908-9.
2005: Sonia Y Hunt; Detering Carsten; Gabriele Varani; David P Jacobus; Guy A Schiehser; Hong-Ming Shieh; Isabelle Nevchas; Jacek Terpinski; Carol Hopkins Sibley
Identification of the optimal third generation antifolate against P. falciparum and P. vivax.
Molecular and biochemical parasitology 2005;144(2):198-205.
2005: Parthasrathy Sampathkumar; Stewart Turley; Jonathan E Ulmer; Ho Gun Rhie; Carol Hopkins Sibley; Wim G J Hol
Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution.
Journal of molecular biology 2005;352(5):1091-104.
2005: William M Watkins; Carol Hopkins Sibley; Ian M Hastings
The search for effective and sustainable treatments for Plasmodium falciparum malaria in Africa: a model of the selection of resistance by antifolate drugs and their combinations.
The American journal of tropical medicine and hygiene 2005;72(2):163-73.
2005: Michele D Hastings; Jason D Maguire; Michael J Bangs; Peter Zimmerman; John C Reeder; J Kevin Baird; Carol Hopkins Sibley
Novel Plasmodium vivax dhfr alleles from the Indonesian Archipelago and Papua New Guinea: association with pyrimethamine resistance determined by a Saccharomyces cerevisiae expression system.
Antimicrobial agents and chemotherapy 2005;49(2):733-40.
2005: Sonia Y Hunt; Brian B Rezvani; Carol Hopkins Sibley
Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.
Molecular and biochemical parasitology 2005;139(1):25-32.
2004: Sarah J Bates; Peter A Winstanley; William M Watkins; Ali Alloueche; Juma Bwika; T Christian Happi; Song Le; James Kublin; Zul Premji; Carol Hopkins Sibley
Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.
The Journal of infectious diseases 2004;190(10):1783-92.
2004: Andre Rosowsky; Ronald A Forsch; Carol Hopkins Sibley; Clark B Inderlied; Sherry F Queener
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Journal of medicinal chemistry 2004;47(6):1475-86.
2004: Michele D Hastings; Kathryn M Porter; Jason D Maguire; Ika Susanti; Winni Kania; Michael J Bangs; Carol Hopkins Sibley; J Kevin Baird
Dihydrofolate reductase mutations in Plasmodium vivax from Indonesia and therapeutic response to sulfadoxine plus pyrimethamine.
The Journal of infectious diseases 2004;189(4):744-50.
2003: Carol Hopkins Sibley; Sonia Y Hunt
Drug resistance in parasites: can we stay ahead of the evolutionary curve?
Trends in parasitology 2003;19(11):532-7.
2002: Michele D Hastings; Sarah J Bates; Eric A Blackstone; Stephanie M Monks; Theonest K Mutabingwa; Carol Hopkins Sibley
Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2002;96(6):674-6.
2002: Alexis Nzila; Edward K Mberu; Eunice Nduati; A Ross; William M Watkins; Carol Hopkins Sibley
Genetic diversity of Plasmodium falciparum parasites from Kenya is not affected by antifolate drug selection.
International journal for parasitology 2002;32(12):1469-76.
2002: A'Lissa B Gerum; Jonathan E Ulmer; David P Jacobus; Norman P Jensen; David R Sherman; Carol Hopkins Sibley
Novel Saccharomyces cerevisiae screen identifies WR99210 analogues that inhibit Mycobacterium tuberculosis dihydrofolate reductase.
Antimicrobial agents and chemotherapy 2002;46(11):3362-9.
2002: Michele D Hastings; Carol Hopkins Sibley
Pyrimethamine and WR99210 exert opposing selection on dihydrofolate reductase from Plasmodium vivax.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):13137-41.
2001: Carol Hopkins Sibley; Ian Macreadie
Novel approaches to tackling malarial drug resistance using yeast.
IUBMB life 2001;52(6):285-9.
2001: Carol Hopkins Sibley; John E Hyde; Paul F G Sims; Christopher Plowe; James Kublin; Edward K Mberu; A F Cowman; Peter A Winstanley; William M Watkins; Alexis Nzila
Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next?
Trends in parasitology 2001;17(12):582-8.
2001: Eleanor G Hankins; david charles warhurst; Carol Hopkins Sibley
Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210.
Molecular and biochemical parasitology 2001;117(1):91-102.
2001: J T Ferlan; S Mookherjee; I N Okezie; L Fulgence; Carol Hopkins Sibley
Mutagenesis of dihydrofolate reductase from Plasmodium falciparum: analysis in Saccharomyces cerevisiae of triple mutant alleles resistant to pyrimethamine or WR99210.
Molecular and biochemical parasitology 2001;113(1):139-50.
2001: H Lau; J T Ferlan; Victoria H Brophy; Andre Rosowsky; Carol Hopkins Sibley
Efficacies of lipophilic inhibitors of dihydrofolate reductase against parasitic protozoa.
Antimicrobial agents and chemotherapy 2001;45(1):187-95.
2000: Victoria H Brophy; J Vasquez; RG Nelson; J R Forney; Andre Rosowsky; Carol Hopkins Sibley
Identification of Cryptosporidium parvum dihydrofolate reductase inhibitors by complementation in Saccharomyces cerevisiae.
Antimicrobial agents and chemotherapy 2000;44(4):1019-28.
2000: Alexis Nzila; Edward K Mberu; J Sulo; H Dayo; Peter A Winstanley; Carol Hopkins Sibley; William M Watkins
Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites.
Antimicrobial agents and chemotherapy 2000;44(4):991-6.
2000: Edward K Mberu; Moses Mosobo; Alexis Nzila; Gilbert O Kokwaro; Carol Hopkins Sibley; William M Watkins
The changing in vitro susceptibility pattern to pyrimethamine/sulfadoxine in Plasmodium falciparum field isolates from Kilifi, Kenya.
The American journal of tropical medicine and hygiene 2000;62(3):396-401.
1999: S Mookherjee; V Howard; A Nzila-Mouanda; W Watkins; Carol Hopkins Sibley
Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples.
The American journal of tropical medicine and hygiene 1999;61(1):131-40.
1998: A Nzila-Mounda; Edward K Mberu; Carol Hopkins Sibley; Christopher Plowe; Peter A Winstanley; William M Watkins
Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain.
Antimicrobial agents and chemotherapy 1998;42(1):164-9.
1998: Victoria H Brophy; Carol Hopkins Sibley
Expression of CD14 corrects the slow response to lipopolysaccharide in the 1B8 mutant of the B cell lymphoma 70Z/3.
Immunogenetics 1998;47(3):196-205.
1997: Carol Hopkins Sibley; Victoria H Brophy; Sandra J Cheesman; K L Hamilton; Eleanor G Hankins; Jason M Wooden; B Kilbey
Yeast as a model system to study drugs effective against apicomplexan proteins.
Methods (San Diego, Calif.) 1997;13(2):190-207.
1997: Jason M Wooden; Leland H Hartwell; B Vasquez; Carol Hopkins Sibley
Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum.
Molecular and biochemical parasitology 1997;85(1):25-40.
1995: O Lawrence; N Rachie; N Qureshi; Karol Bomsztyk; Carol Hopkins Sibley
Diphosphoryl lipid A from Rhodobacter sphaeroides transiently activates NF-kappa B but inhibits lipopolysaccharide induction of kappa light chain and Oct-2 in the B-cell lymphoma line 70Z/3.
Infection and immunity 1995;63(3):1040-6.
1994: L D Rhodes; A T Paull; Carol Hopkins Sibley
Two different IFN-gamma nonresponsive variants derived from the B-cell lymphoma 70Z/3.
Immunogenetics 1994;40(3):199-209.
1993: Jason M Wooden; S Kyes; Carol Hopkins Sibley
PCR and strain identification in Plasmodium falciparum.
Parasitology today (Personal ed.) 1993;9(8):303-5.
1992: Jason M Wooden; E E Gould; A T Paull; Carol Hopkins Sibley
Plasmodium falciparum: a simple polymerase chain reaction method for differentiating strains.
Experimental parasitology 1992;75(2):207-12.
1992: P M Dubois; J Stepinski; J Urbain; Carol Hopkins Sibley
Role of the transmembrane and cytoplasmic domains of surface IgM in endocytosis and signal transduction.
European journal of immunology 1992;22(3):851-7.
1991: J W Rooney; P M Dubois; Carol Hopkins Sibley
Cross-linking of surface IgM activates NF-kappa B in B lymphocyte.
European journal of immunology 1991;21(12):2993-8.
1991: C L Miller; A L Feldhaus; J W Rooney; L D Rhodes; Carol Hopkins Sibley; Harinder Singh
Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation.
Molecular and cellular biology 1991;11(10):4885-94.
1991: Jerzy Ostrowski; John E Sims; Carol Hopkins Sibley; M A Valentine; Steven K Dower; Kathryn E Meier; Karol Bomsztyk
A serine/threonine kinase activity is closely associated with a 65-kDa phosphoprotein specifically recognized by the kappa B enhancer element.
The Journal of biological chemistry 1991;266(19):12722-33.
1991: Karol Bomsztyk; J W Rooney; T Iwasaki; N A Rachie; Steven K Dower; Carol Hopkins Sibley
Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.
Cell regulation 1991;2(4):329-35.
1990: Jerzy Ostrowski; Carol Hopkins Sibley; J Stepinski; T H Stanton; L L Smith; Karol Bomsztyk
Weak bases increase surface IgM expression in 70Z/3 B lymphoid cell line without increasing kappa gene expression.
Cellular immunology 1990;130(1):11-21.
1990: Karol Bomsztyk; Bert Toivola; David W Emery; J W Rooney; Steven K Dower; N A Rachie; Carol Hopkins Sibley
Role of cAMP in interleukin-1-induced kappa light chain gene expression in murine B cell line.
The Journal of biological chemistry 1990;265(16):9413-7.
1990: J W Rooney; David W Emery; Carol Hopkins Sibley
Slow response variant of the B lymphoma 70Z/3 defective in LPS activation of NF-kappa B.
Immunogenetics 1990;31(2):65-72.
1990: J W Rooney; David W Emery; Carol Hopkins Sibley
1.3E2, a variant of the B lymphoma 70Z/3, defective in activation of NF-kappa B and OTF-2.
Immunogenetics 1990;31(2):73-8.
1989: David W Emery; J W Rooney; Carol Hopkins Sibley
A gamma interferon-unresponsive variant of cell line 70Z/3, IFN-4, can be partially rescued by phorbol myristate acetate.
Molecular and cellular biology 1989;9(11):5231-3.
1988: Carol Hopkins Sibley; A Terry; C R Raetz
Induction of kappa light chain synthesis in 70Z/3 B lymphoma cells by chemically defined lipid A precursors.
The Journal of biological chemistry 1988;263(11):5098-103.
1988: R S Weeks; Carol Hopkins Sibley
Inducible expression of transfected kappa light chains by lipopolysaccharide and IFN-gamma in the murine B lymphoma, 70Z/3.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1312-20.
1987: R S Weeks; Carol Hopkins Sibley
Molecular analysis of immunoglobulin expression in variants of murine B lymphoma, 70Z/3.
Somatic cell and molecular genetics 1987;13(3):205-19.
1984: R S Weeks; P E Mains; Carol Hopkins Sibley
Comparison of membrane IgM expression in the murine B cell lymphoma 70Z/3 treated with LPS or supernatant containing T cell factors.
Journal of immunology (Baltimore, Md. : 1950) 1984;133(1):351-8.
1983: P E Mains; Carol Hopkins Sibley
LPS-nonresponsive variants of mouse B cell lymphoma, 70Z/3: isolation and characterization.
Somatic cell genetics 1983;9(6):699-720.
1983: P E Mains; Carol Hopkins Sibley
The requirement of light chain for the surface deposition of the heavy chain of immunoglobulin M.
The Journal of biological chemistry 1983;258(8):5027-33.
1982: P E Mains; Carol Hopkins Sibley
Control of IgM synthesis in the murine pre-B cell line, 70Z/3'.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(4):1664-70.