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David Sibley

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Sebastian Lourido; Kevan M Shokat; Jennifer Barks; Michael S Lopez; Keliang Tang; Qiuling Wang; Scott A Wildman; Chao Zhang; L David Sibley
Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.
Elizabeth M Selleck; Herbert W Virgin; Wandy L Beatty; Daniel Degrandi; Sarah J Fentress; John D MacMicking; Klaus Pfeffer; L David Sibley
Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii.
Sebastian Lourido; Keliang Tang; L David Sibley
Distinct signalling pathways control Toxoplasma egress and host-cell invasion.

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2013: Sebastian Lourido; Kevan M Shokat; Jennifer Barks; Michael S Lopez; Keliang Tang; Qiuling Wang; Scott A Wildman; Chao Zhang; L David Sibley
Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.
Journal of medicinal chemistry 2013;56(7):3068-77.
2013: Elizabeth M Selleck; Herbert W Virgin; Wandy L Beatty; Daniel Degrandi; Sarah J Fentress; John D MacMicking; Klaus Pfeffer; L David Sibley
Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii.
PLoS pathogens 2013;9(4):e1003320.
2012: Sebastian Lourido; Keliang Tang; L David Sibley
Distinct signalling pathways control Toxoplasma egress and host-cell invasion.
The EMBO journal 2012;31(24):4524-34.
2012: Sarah J Fentress; Jonathan C Howard; Tobias Steinfeldt; L David Sibley
The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.
Cellular microbiology 2012;14(12):1921-33.
2012: Roxane Tussiwand; Leslie A Weiss; Xiaodi Wu; K C Wumesh; Theresa L Murphy; Jeffrey A Rotondo; Ansuman T Satpathy; Robert D Schreiber; L David Sibley; Harinder Singh; Christina L Stallings; Jörn C Albring; Cora T Aurthur; Michael Behnke; Brian T Edelson; Elke Glasmacher; Nicole M Kretzer; Samuel S K Lam; Wan-Ling Lee; Warren J Leonard; Peng Li; Wei Liao; Mona Mashayekhi; Kenneth M Murphy
Compensatory dendritic cell development mediated by BATF-IRF interactions.
Nature 2012;490(7421):502-7.
2012: Bang Shen; L David Sibley
The moving junction, a key portal to host cell invasion by apicomplexan parasites.
Current opinion in microbiology 2012;15(4):449-55.
2012: Kristen M Skillman; Dominique Soldati-Favre; Wassim Daher; Christopher I Ma; L David Sibley
Toxoplasma gondii profilin acts primarily to sequester G-actin while formins efficiently nucleate actin filament formation in vitro.
Biochemistry 2012;51(12):2486-95.
2012: Michael S Behnke; Sarah J Fentress; Lucy X Li; Mona Mashayekhi; Gregory A Taylor; L David Sibley
The polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18.
PLoS pathogens 2012;8(11):e1002992.
2011: Kristen M Skillman; Keliang Tang; Karthikeyan Diraviyam; Asis Khan; David Sept; L David Sibley
Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites.
PLoS pathogens 2011;7(10):e1002280.
2011: Sarah J Fentress; L David Sibley
The secreted kinase ROP18 defends Toxoplasma's border.
BioEssays : news and reviews in molecular, cellular and developmental biology 2011;33(9):693-700.
2011: Mona Mashayekhi; Ildiko R Dunay; Eva M Frickel; Romina S Goldszmid; Asis Khan; Theresa L Murphy; Hidde L Ploegh; Michelle Sandau; Alan Sher; L David Sibley; Kenneth M Murphy
CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.
Immunity 2011;35(2):249-59.
2011: Michael S Behnke; Jitender P Dubey; Asis Khan; Keliang Tang; John C Wootton; L David Sibley
Virulence differences in Toxoplasma mediated by amplification of a family of polymorphic pseudokinases.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(23):9631-6.
2011: Asis Khan; JP Dubey; Chunlei Su; James W Ajioka; Benjamin Rosenthal; L David Sibley
Genetic analyses of atypical Toxoplasma gondii strains reveal a fourth clonal lineage in North America.
International journal for parasitology 2011;41(6):645-55.
2011: Simren Mehta; L David Sibley
Actin depolymerizing factor controls actin turnover and gliding motility in Toxoplasma gondii.
Molecular biology of the cell 2011;22(8):1290-9.
2011: Asis Khan; Natalie Miller; David S Roos; Benjamin Rosenthal; James W Ajioka; Daniel Ajzenberg; Marie-Laure Dardé; J P Dubey; L David Sibley
A monomorphic haplotype of chromosome Ia is associated with widespread success in clonal and nonclonal populations of Toxoplasma gondii.
mBio 2011;2(6):e00228-11.
2010: Sarah J Fentress; Michael S Behnke; Ildiko R Dunay; Mona Mashayekhi; Leah M Rommereim; Barbara A Fox; David J Bzik; Gregory A Taylor; Benjamin E Turk; Cheryl F Lichti; R Reid Townsend; Wei Qiu; Raymond Hui; Wandy L Beatty; L David Sibley
Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.
Cell host & microbe 2010;8(6):484-95.
2010: L David Sibley
How apicomplexan parasites move in and out of cells.
Current opinion in biotechnology 2010;21(5):592-8.
2010: Ildiko R Dunay; L David Sibley
Monocytes mediate mucosal immunity to Toxoplasma gondii.
Current opinion in immunology 2010;22(4):461-6.
2010: Sebastian Lourido; Joel Shuman; Chao Zhang; Kevan M Shokat; Raymond Hui; L David Sibley
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.
Nature 2010;465(7296):359-62.
2010: Jeffrey S Buguliskis; Fabien Brossier; Joel Shuman; L David Sibley
Rhomboid 4 (ROM4) affects the processing of surface adhesins and facilitates host cell invasion by Toxoplasma gondii.
PLoS pathogens 2010;6(4):e1000858.
2010: Ildiko R Dunay; Anja Fuchs; L David Sibley
Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice.
Infection and immunity 2010;78(4):1564-70.
2010: Simren Mehta; L David Sibley
Toxoplasma gondii actin depolymerizing factor acts primarily to sequester G-actin.
The Journal of biological chemistry 2010;285(9):6835-47.
2010: Jennifer L Gordon; Jeffrey S Buguliskis; Paul J Buske; L David Sibley
Actin-like protein 1 (ALP1) is a component of dynamic, high molecular weight complexes in Toxoplasma gondii.
Cytoskeleton (Hoboken, N.J.) 2010;67(1):23-31.
2009: Asis Khan; Michael S Behnke; Ildiko R Dunay; Michael W White; L David Sibley
Phenotypic and gene expression changes among clonal type I strains of Toxoplasma gondii.
Eukaryotic cell 2009;8(12):1828-36.
2009: Ildiko R Dunay; Wing Chi Chan; Richard K Haynes; L David Sibley
Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model.
Antimicrobial agents and chemotherapy 2009;53(10):4450-6.
2009: L David Sibley; Asis Khan; James W Ajioka; Benjamin Rosenthal
Genetic diversity of Toxoplasma gondii in animals and humans.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2009;364(1530):2749-61.
2009: L David Sibley; Wei Qiu; Sarah Fentress; Sonya J Taylor; Asis Khan; Raymond Hui
Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis.
Eukaryotic cell 2009;8(8):1085-93.
2009: L David Sibley
Development of forward genetics in Toxoplasma gondii.
International journal for parasitology 2009;39(8):915-24.
2009: G Lucas Starnes; Mathieu Coincon; Jurgen Sygusch; L David Sibley
Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells.
Cell host & microbe 2009;5(4):353-64.
2009: Asis Khan; Sonya Taylor; James W Ajioka; Benjamin Rosenthal; L David Sibley
Selection at a single locus leads to widespread expansion of Toxoplasma gondii lineages that are virulent in mice.
PLoS genetics 2009;5(3):e1000404.
2008: Zijiang Zhao; Blima Fux; Megan Goodwin; Ildiko R Dunay; David Strong; Brian C Miller; Ken Cadwell; Monica A Delgado; Marisa Ponpuak; Karen G Green; Robert E Schmidt; Noboru Mizushima; Vojo Deretic; L David Sibley; Herbert W Virgin
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.
Cell host & microbe 2008;4(5):458-69.
2008: Jennifer L Gordon; Wandy L Beatty; L David Sibley
A novel actin-related protein is associated with daughter cell formation in Toxoplasma gondii.
Eukaryotic cell 2008;7(9):1500-12.
2008: Ildiko R Dunay; Renato A Damatta; Blima Fux; Rachel Presti; Suellen Greco; Marco Colonna; L David Sibley
Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii.
Immunity 2008;29(2):306-17.
2008: Fabien Brossier; G Lucas Starnes; Wandy L Beatty; L David Sibley
Microneme rhomboid protease TgROM1 is required for efficient intracellular growth of Toxoplasma gondii.
Eukaryotic cell 2008;7(4):664-74.
2008: Kisaburo Nagamune; Leslie M Hicks; Blima Fux; Fabien Brossier; Eduardo N Chini; L David Sibley
Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.
Nature 2008;451(7175):207-10.
2008: L David Sibley; James W Ajioka
Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps.
Annual review of microbiology 2008;62():329-51.
2008: Kisaburo Nagamune; Silvia N J Moreno; Eduardo N Chini; L David Sibley
Calcium regulation and signaling in apicomplexan parasites.
Sub-cellular biochemistry 2008;47():70-81.
2007: Kisaburo Nagamune; Wandy L Beatty; L David Sibley
Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii.
Eukaryotic cell 2007;6(11):2147-56.
2007: Kisaburo Nagamune; Silvia N J Moreno; L David Sibley
Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis.
Antimicrobial agents and chemotherapy 2007;51(11):3816-23.
2007: Asis Khan; Blima Fux; Chunlei Su; JP Dubey; M L Darde; James W Ajioka; Benjamin Rosenthal; L David Sibley
Recent transcontinental sweep of Toxoplasma gondii driven by a single monomorphic chromosome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14872-7.
2007: Blima Fux; Julie Nawas; Asis Khan; Darcy B Gill; Chunlei Su; L David Sibley
Toxoplasma gondii strains defective in oral transmission are also defective in developmental stage differentiation.
Infection and immunity 2007;75(5):2580-90.
2006: jeroen saeij; Jon P Boyle; Susan Coller; S Taylor; L David Sibley; E T Brooke-Powell; James W Ajioka; John C Boothroyd
Polymorphic secreted kinases are key virulence factors in toxoplasmosis.
Science (New York, N.Y.) 2006;314(5806):1780-3.
2006: S Taylor; Antonio Barragan; Chunlei Su; Blima Fux; S J Fentress; Keliang Tang; Wandy L Beatty; H El Hajj; Maria E Jerome; M S Behnke; M White; J C Wootton; L David Sibley
A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii.
Science (New York, N.Y.) 2006;314(5806):1776-80.
2006: G Lucas Starnes; Travis J Jewett; Vernon Bruce Carruthers; L David Sibley
Two separate, conserved acidic amino acid domains within the Toxoplasma gondii MIC2 cytoplasmic tail are required for parasite survival.
The Journal of biological chemistry 2006;281(41):30745-54.
2006: Kisaburo Nagamune; L David Sibley
Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa.
Molecular biology and evolution 2006;23(8):1613-27.
2006: Jon P Boyle; Badri Rajasekar; jeroen saeij; James W Ajioka; Matthew Berriman; Ian Paulsen; David S Roos; L David Sibley; Michael W White; John C Boothroyd
Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(27):10514-9.
2006: Dorota Nowakowska; Iris Colón; Jack S Remington; Michael Grigg; Elzbieta Golab; Jan Wilczynski; L David Sibley
Genotyping of Toxoplasma gondii by multiplex PCR and peptide-based serological testing of samples from infants in Poland diagnosed with congenital toxoplasmosis.
Journal of clinical microbiology 2006;44(4):1382-9.
2006: Nivedita Sahoo; Wandy L Beatty; John Edward Heuser; David Sept; L David Sibley
Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii.
Molecular biology of the cell 2006;17(2):895-906.
2005: Asis Khan; Chunlei Su; M German; G A Storch; D B Clifford; L David Sibley
Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains.
Journal of clinical microbiology 2005;43(12):5881-7.
2005: Eduardo N Chini; Kisaburo Nagamune; Dawn M Wetzel; L David Sibley
Evidence that the cADPR signalling pathway controls calcium-mediated microneme secretion in Toxoplasma gondii.
The Biochemical journal 2005;389(Pt 2):269-77.
2005: Paul M Robben; Marie LaRegina; William Kuziel; L David Sibley
Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis.
The Journal of experimental medicine 2005;201(11):1761-9.
2005: Antonio Barragan; Fabien Brossier; L David Sibley
Transepithelial migration of Toxoplasma gondii involves an interaction of intercellular adhesion molecule 1 (ICAM-1) with the parasite adhesin MIC2.
Cellular microbiology 2005;7(4):561-8.
2005: Fabien Brossier; Travis J Jewett; L David Sibley; Sinisa Urban
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):4146-51.
2005: Jennifer L Gordon; L David Sibley
Comparative genome analysis reveals a conserved family of actin-like proteins in apicomplexan parasites.
BMC genomics 2005;6():179.
2005: Asis Khan; Sonya Taylor; Chunlei Su; Aaron J Mackey; Jon Boyle; Robert Cole; Darius Glover; Keliang Tang; Ian Paulsen; Matthew Berriman; John C Boothroyd; Elmer R Pfefferkorn; J P Dubey; James W Ajioka; David S Roos; John C Wootton; L David Sibley
Composite genome map and recombination parameters derived from three archetypal lineages of Toxoplasma gondii.
Nucleic acids research 2005;33(9):2980-92.
2004: Dawn M Wetzel; Lea Ann Chen; Felix A Ruiz; Silvia N J Moreno; L David Sibley
Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii.
Journal of cell science 2004;117(Pt 24):5739-48.
2004: Audra J Charron; L David Sibley
Molecular partitioning during host cell penetration by Toxoplasma gondii.
Traffic (Copenhagen, Denmark) 2004;5(11):855-67.
2004: L David Sibley
Intracellular parasite invasion strategies.
Science (New York, N.Y.) 2004;304(5668):248-53.
2004: Paul M Robben; L David Sibley
Food- and waterborne pathogens: you are (infected by) what you eat!
Microbes and infection / Institut Pasteur 2004;6(4):406-13.
2004: Naomi S Morrissette; Arpita Mitra; David Sept; L David Sibley
Dinitroanilines bind alpha-tubulin to disrupt microtubules.
Molecular biology of the cell 2004;15(4):1960-8.
2004: Paul M Robben; Dana Mordue; Steven M Truscott; Kiyoshi Takeda; Shizuo Akira; L David Sibley
Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3686-94.
2004: Travis J Jewett; L David Sibley
The toxoplasma proteins MIC2 and M2AP form a hexameric complex necessary for intracellular survival.
The Journal of biological chemistry 2004;279(10):9362-9.
2004: Chunlei Su; Christian T Hott; Bernard H Brownstein; L David Sibley
Typing single-nucleotide polymorphisms in Toxoplasma gondii by allele-specific primer extension and microarray detection.
Methods in molecular biology (Clifton, N.J.) 2004;270():249-62.
2004: Li Li; Jonathan Crabtree; Steve Fischer; Deborah F Pinney; Christian J Stoeckert; L David Sibley; David S Roos
ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites.
Nucleic acids research 2004;32(Database issue):D326-8.
2003: Dana Mordue; L David Sibley
A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis.
Journal of leukocyte biology 2003;74(6):1015-25.
2003: Antonio Barragan; L David Sibley
Migration of Toxoplasma gondii across biological barriers.
Trends in microbiology 2003;11(9):426-30.
2003: L David Sibley
Toxoplasma gondii: perfecting an intracellular life style.
Traffic (Copenhagen, Denmark) 2003;4(9):581-6.
2003: Jennie L Lovett; L David Sibley
Intracellular calcium stores in Toxoplasma gondii govern invasion of host cells.
Journal of cell science 2003;116(Pt 14):3009-16.
2003: My-Hang Huynh; Karen E Rabenau; Jill Harper; Wandy L Beatty; L David Sibley; Vernon Bruce Carruthers
Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex.
The EMBO journal 2003;22(9):2082-90.
2003: Travis J Jewett; L David Sibley
Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites.
Molecular cell 2003;11(4):885-94.
2003: Li Li; Brian P Brunk; Jessica Kissinger; Deana Pape; Keliang Tang; Robert H Cole; John Martin; Todd Wylie; Mike Dante; Steven J Fogarty; Daniel K Howe; Paul A Liberator; Carmen Diaz; Jennifer Anderson; Michael White; Maria E Jerome; Emily A Johnson; Jay A Radke; Christian J Stoeckert; Robert H Waterston; Sandra W Clifton; David S Roos; L David Sibley
Gene discovery in the apicomplexa as revealed by EST sequencing and assembly of a comparative gene database.
Genome research 2003;13(3):443-54.
2003: Fabien Brossier; Travis J Jewett; Jennie L Lovett; L David Sibley
C-terminal processing of the toxoplasma protein MIC2 is essential for invasion into host cells.
The Journal of biological chemistry 2003;278(8):6229-34.
2003: D M Wetzel; S Håkansson; K Hu; D Roos; L David Sibley
Actin filament polymerization regulates gliding motility by apicomplexan parasites.
Molecular biology of the cell 2003;14(2):396-406.
2003: Chunlei Su; D Evans; R H Cole; Jessica Kissinger; James W Ajioka; L David Sibley
Recent expansion of Toxoplasma through enhanced oral transmission.
Science (New York, N.Y.) 2003;299(5605):414-6.
2002: Chunlei Su; Daniel K Howe; JP Dubey; James W Ajioka; L David Sibley
Identification of quantitative trait loci controlling acute virulence in Toxoplasma gondii.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(16):10753-8.
2002: Audra J Charron; L David Sibley
Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii.
Journal of cell science 2002;115(Pt 15):3049-59.
2002: Jennie L Lovett; Norma Marchesini; Silvia N J Moreno; L David Sibley
Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))/ryanodine-sensitive stores.
The Journal of biological chemistry 2002;277(29):25870-6.
2002: Jitender P Dubey; Bradd C Barr; John R Barta; I Bjerkås; Camilla Björkman; Byron L Blagburn; D D Bowman; D Buxton; J T Ellis; Bruno Gottstein; A Hemphill; Dolores E Hill; Daniel K Howe; Mark C Jenkins; Y Kobayashi; B Koudela; Antoinette E Marsh; Jens G Mattsson; Milton M McAllister; D Modrý; Y Omata; L David Sibley; Clarence A Speer; Alexander J Trees; Arvid Uggla; Steve J Upton; D J L Williams; David S Lindsay
Redescription of Neospora caninum and its differentiation from related coccidia.
International journal for parasitology 2002;32(8):929-46.
2002: Antonio Barragan; L David Sibley
Transepithelial migration of Toxoplasma gondii is linked to parasite motility and virulence.
The Journal of experimental medicine 2002;195(12):1625-33.
2002: Daniel K Howe; Keliang Tang; Patricia A Conrad; Karen W Sverlow; JP Dubey; L David Sibley
Sensitive and specific identification of Neospora caninum infection of cattle based on detection of serum antibodies to recombinant Ncp29.
Clinical and diagnostic laboratory immunology 2002;9(3):611-5.
2002: Naomi S Morrissette; L David Sibley
Cytoskeleton of apicomplexan parasites.
Microbiology and molecular biology reviews : MMBR 2002;66(1):21-38; table of contents.
2002: Naomi S Morrissette; L David Sibley
Disruption of microtubules uncouples budding and nuclear division in Toxoplasma gondii.
Journal of cell science 2002;115(Pt 5):1017-25.
2002: L David Sibley; Dana Mordue; Chunlei Su; Paul M Robben; Daniel K Howe
Genetic approaches to studying virulence and pathogenesis in Toxoplasma gondii.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2002;357(1417):81-8.
2001: Dana Mordue; F Monroy; M La Regina; C A Dinarello; L David Sibley
Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4574-84.
2001: S Håkansson; Audra J Charron; L David Sibley
Toxoplasma evacuoles: a two-step process of secretion and fusion forms the parasitophorous vacuole.
The EMBO journal 2001;20(12):3132-44.
2001: Stephan Brecht; Vernon Bruce Carruthers; D J P Ferguson; OK Giddings; G Wang; U Jakle; Jill Harper; L David Sibley; Dominique Soldati
The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains.
The Journal of biological chemistry 2001;276(6):4119-27.
2000: Vernon Bruce Carruthers; S Håkansson; OK Giddings; L David Sibley
Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment.
Infection and immunity 2000;68(7):4005-11.
2000: Vernon Bruce Carruthers; G D Sherman; L David Sibley
The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases.
The Journal of biological chemistry 2000;275(19):14346-53.
2000: Jennie L Lovett; Daniel K Howe; L David Sibley
Molecular characterization of a thrombospondin-related anonymous protein homologue in Neospora caninum.
Molecular and biochemical parasitology 2000;107(1):33-43.
2000: L David Sibley; Norma W Andrews
Cell invasion by un-palatable parasites.
Traffic (Copenhagen, Denmark) 2000;1(2):100-6.
1999: Dana Mordue; N Desai; M Dustin; L David Sibley
Invasion by Toxoplasma gondii establishes a moving junction that selectively excludes host cell plasma membrane proteins on the basis of their membrane anchoring.
The Journal of experimental medicine 1999;190(12):1783-92.
1999: L David Sibley; Dana Mordue; Daniel K Howe
Experimental approaches to understanding virulence in toxoplasmosis.
Immunobiology 1999;201(2):210-24.
1999: Vernon Bruce Carruthers; OK Giddings; L David Sibley
Secretion of micronemal proteins is associated with toxoplasma invasion of host cells.
Cellular microbiology 1999;1(3):225-35.
1999: S Håkansson; H Morisaki; John Edward Heuser; L David Sibley
Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion.
Molecular biology of the cell 1999;10(11):3539-47.
1999: Daniel K Howe; L David Sibley
Comparison of the major antigens of Neospora caninum and Toxoplasma gondii.
International journal for parasitology 1999;29(10):1489-96.
1999: Vernon Bruce Carruthers; Silvia N J Moreno; L David Sibley
Ethanol and acetaldehyde elevate intracellular [Ca2+] and stimulate microneme discharge in Toxoplasma gondii.
The Biochemical journal 1999;342 ( Pt 2)():379-86.
1999: E Labruyere; M Lingnau; C Mercier; L David Sibley
Differential membrane targeting of the secretory proteins GRA4 and GRA6 within the parasitophorous vacuole formed by Toxoplasma gondii.
Molecular and biochemical parasitology 1999;102(2):311-24.
1999: Dana Mordue; S Håkansson; I Niesman; L David Sibley
Toxoplasma gondii resides in a vacuole that avoids fusion with host cell endocytic and exocytic vesicular trafficking pathways.
Experimental parasitology 1999;92(2):87-99.
1999: Vernon Bruce Carruthers; L David Sibley
Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii.
Molecular microbiology 1999;31(2):421-8.
1998: Daniel K Howe; A C Crawford; D Lindsay; L David Sibley
The p29 and p35 immunodominant antigens of Neospora caninum tachyzoites are homologous to the family of surface antigens of Toxoplasma gondii.
Infection and immunity 1998;66(11):5322-8.
1998: C Mercier; Daniel K Howe; Dana Mordue; M Lingnau; L David Sibley
Targeted disruption of the GRA2 locus in Toxoplasma gondii decreases acute virulence in mice.
Infection and immunity 1998;66(9):4176-82.
1998: C Mercier; M F Cesbron-Delauw; L David Sibley
The amphipathic alpha helices of the toxoplasma protein GRA2 mediate post-secretory membrane association.
Journal of cell science 1998;111 ( Pt 15)():2171-80.
1998: R Mondragon; Daniel K Howe; JP Dubey; L David Sibley
Genotypic analysis of Toxoplasma gondii isolates from pigs.
The Journal of parasitology 1998;84(3):639-41.
1998: Ian D Manger; Adrian Hehl; Stephen Parmley; L David Sibley; M Marra; LaDeana W Hillier; Robert H Waterston; John C Boothroyd
Expressed sequence tag analysis of the bradyzoite stage of Toxoplasma gondii: identification of developmentally regulated genes.
Infection and immunity 1998;66(4):1632-7.
1998: James W Ajioka; John C Boothroyd; Brian P Brunk; Adrian Hehl; LaDeana W Hillier; Ian D Manger; M Marra; G C Overton; David S Roos; Kiew-Lian Wan; Robert H Waterston; L David Sibley
Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the Apicomplexa.
Genome research 1998;8(1):18-28.
1998: L David Sibley; S Hâkansson; Vernon Bruce Carruthers
Gliding motility: an efficient mechanism for cell penetration.
Current biology : CB 1998;8(1):R12-4.
1997: Dana Mordue; L David Sibley
Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4452-9.
1997: Daniel K Howe; L David Sibley
Development of molecular genetics for Neospora caninum: A complementary system to Toxoplasma gondii.
Methods (San Diego, Calif.) 1997;13(2):123-33.
1997: JM Dobrowolski; Vernon Bruce Carruthers; L David Sibley
Participation of myosin in gliding motility and host cell invasion by Toxoplasma gondii.
Molecular microbiology 1997;26(1):163-73.
1997: M L Allen; J M Dobrowolski; H Muller; L David Sibley; T E Mansour
Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii.
Molecular and biochemical parasitology 1997;88(1-2):43-52.
1997: Vernon Bruce Carruthers; L David Sibley
Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts.
European journal of cell biology 1997;73(2):114-23.
1997: Daniel K Howe; S Honoré; Francis Derouin; L David Sibley
Determination of genotypes of Toxoplasma gondii strains isolated from patients with toxoplasmosis.
Journal of clinical microbiology 1997;35(6):1411-4.
1997: Daniel K Howe; C Mercier; M Messina; L David Sibley
Expression of Toxoplasma gondii genes in the closely-related apicomplexan parasite Neospora caninum.
Molecular and biochemical parasitology 1997;86(1):29-36.
1997: JM Dobrowolski; L David Sibley
The role of the cytoskeleton in host cell invasion by Toxoplasma gondii.
Behring Institute Mitteilungen 1997;(99):90-6.
1997: Kiew-Lian Wan; Vernon Bruce Carruthers; L David Sibley; James W Ajioka
Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2.
Molecular and biochemical parasitology 1997;84(2):203-14.
1997: JM Dobrowolski; I R Niesman; L David Sibley
Actin in the parasite Toxoplasma gondii is encoded by a single copy gene, ACT1 and exists primarily in a globular form.
Cell motility and the cytoskeleton 1997;37(3):253-62.
1996: Daniel K Howe; B C Summers; L David Sibley
Acute virulence in mice is associated with markers on chromosome VIII in Toxoplasma gondii.
Infection and immunity 1996;64(12):5193-8.
1996: M Messina; S Kim; L David Sibley
A family of dispersed DNA elements that contain GAA repeats in Toxoplasma gondii.
Molecular and biochemical parasitology 1996;81(2):247-52.
1996: J M Dobrowolski; L David Sibley
Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite.
Cell 1996;84(6):933-9.
1996: L David Sibley; Daniel K Howe
Genetic basis of pathogenicity in toxoplasmosis.
Current topics in microbiology and immunology 1996;219():3-15.
1995: Daniel K Howe; L David Sibley
Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease.
The Journal of infectious diseases 1995;172(6):1561-6.
1995: M Messina; I Niesman; C Mercier; L David Sibley
Stable DNA transformation of Toxoplasma gondii using phleomycin selection.
Gene 1995;165(2):213-7.
1995: L David Sibley; I R Niesman; Stephen Parmley; Marie-France Cesbron-Delauw
Regulated secretion of multi-lamellar vesicles leads to formation of a tubulo-vesicular network in host-cell vacuoles occupied by Toxoplasma gondii.
Journal of cell science 1995;108 ( Pt 4)():1669-77.
1994: L David Sibley; I R Niesman; T Asai; T Takeuchi
Toxoplasma gondii: secretion of a potent nucleoside triphosphate hydrolase into the parasitophorous vacuole.
Experimental parasitology 1994;79(3):301-11.
1994: Stephen Parmley; S Yang; Günter Harth; L David Sibley; A Sucharczuk; Jack S Remington
Molecular characterization of a 65-kilodalton Toxoplasma gondii antigen expressed abundantly in the matrix of tissue cysts.
Molecular and biochemical parasitology 1994;66(2):283-96.
1994: L David Sibley; M Messina; I R Niesman
Stable DNA transformation in the obligate intracellular parasite Toxoplasma gondii by complementation of tryptophan auxotrophy.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5508-12.
1994: Daniel K Howe; L David Sibley
Toxoplasma gondii: analysis of different laboratory stocks of the RH strain reveals genetic heterogeneity.
Experimental parasitology 1994;78(2):242-5.
1993: L David Sibley; E R Pfefferkorn; John C Boothroyd
Development of genetic systems for Toxoplasma gondii.
Parasitology today (Personal ed.) 1993;9(10):392-5.
1993: L David Sibley
Interactions between Toxoplasma gondii and its mammalian host cells.
Seminars in cell biology 1993;4(5):335-44.
1993: L David Sibley; Linda B Adams; James L Krahenbuhl
Macrophage interactions in toxoplasmosis.
Research in immunology 1993;144(1):38-40.
1993: John C Boothroyd; L David Sibley
Population biology of Toxoplasma gondii.
Research in immunology 1993;144(1):14-6.
1992: L David Sibley; A J LeBlanc; E R Pfefferkorn; John C Boothroyd
Generation of a restriction fragment length polymorphism linkage map for Toxoplasma gondii.
Genetics 1992;132(4):1003-15.
1992: L David Sibley; John C Boothroyd
Virulent strains of Toxoplasma gondii comprise a single clonal lineage.
Nature 1992;359(6390):82-5.
1992: L David Sibley; John C Boothroyd
Construction of a molecular karyotype for Toxoplasma gondii.
Molecular and biochemical parasitology 1992;51(2):291-300.
1991: P N Ossorio; L David Sibley; John C Boothroyd
Mitochondrial-like DNA sequences flanked by direct and inverted repeats in the nuclear genome of Toxoplasma gondii.
Journal of molecular biology 1991;222(3):525-36.
1991: L David Sibley; E R Pfefferkorn; John C Boothroyd
Proposal for a uniform genetic nomenclature in Toxoplasma gondii.
Parasitology today (Personal ed.) 1991;7(12):327-8.
1991: L David Sibley; Linda B Adams; Y Fukutomi; James L Krahenbuhl
Tumor necrosis factor-alpha triggers antitoxoplasmal activity of IFN-gamma primed macrophages.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(7):2340-5.
1990: James L Krahenbuhl; L David Sibley; G T Chae
Gamma interferon in experimental leprosy.
Diagnostic microbiology and infectious disease 1990;13(5):405-9.
1990: L David Sibley; Linda B Adams; James L Krahenbuhl
Inhibition of interferon-gamma-mediated activation in mouse macrophages treated with lipoarabinomannan.
Clinical and experimental immunology 1990;80(1):141-8.
1988: L David Sibley; James L Krahenbuhl
Modification of host cell phagosomes by Toxoplasma gondii involves redistribution of surface proteins and secretion of a 32 kDa protein.
European journal of cell biology 1988;47(1):81-7.
1988: L David Sibley; James L Krahenbuhl
Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae.
Infection and immunity 1988;56(8):1912-9.
1988: L David Sibley; S W Hunter; P J Brennan; James L Krahenbuhl
Mycobacterial lipoarabinomannan inhibits gamma interferon-mediated activation of macrophages.
Infection and immunity 1988;56(5):1232-6.
1988: L David Sibley; James L Krahenbuhl
Defective activation of granuloma macrophages from Mycobacterium leprae-infected nude mice.
Journal of leukocyte biology 1988;43(1):60-6.
1987: L David Sibley; Scott Franzblau; James L Krahenbuhl
Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages.
Infection and immunity 1987;55(3):680-5.
1987: L David Sibley; James L Krahenbuhl
Mycobacterium leprae-burdened macrophages are refractory to activation by gamma interferon.
Infection and immunity 1987;55(2):446-50.
1986: L David Sibley; James L Krahenbuhl; G M Adams; E Weidner
Toxoplasma modifies macrophage phagosomes by secretion of a vesicular network rich in surface proteins.
The Journal of cell biology 1986;103(3):867-74.
1986: L David Sibley; R Lawson; E Weidner
Superoxide dismutase and catalase in Toxoplasma gondii.
Molecular and biochemical parasitology 1986;19(1):83-7.
1985: L David Sibley; James L Krahenbuhl; E Weidner
Lymphokine activation of J774G8 cells and mouse peritoneal macrophages challenged with Toxoplasma gondii.
Infection and immunity 1985;49(3):760-4.
1985: L David Sibley; E Weidner; James L Krahenbuhl
Phagosome acidification blocked by intracellular Toxoplasma gondii.
Nature 1985;315(6018):416-9.
1985: E Weidner; L David Sibley
Phagocytized intracellular microsporidian blocks phagosome acidification and phagosome-lysosome fusion.
The Journal of protozoology 1985;32(2):311-7.