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Filomena Sica

Research Profile

Procedures

X Ray Crystallography

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TOP 3
Andrea Pica; Irene Russo Krauss; Filomena Sica; Immacolata Castellano; Giuseppe Graziano; Francesco La Cara; Antonello Merlino
Effect of NaCl on the conformational stability of the thermophilic γ-glutamyltranspeptidase from Geobacillus thermodenitrificans: Implication for globular protein halotolerance.
Irene Russo Krauss; Lelio Mazzarella; Antonello Merlino; Ettore Novellino; Antonio Randazzo; Filomena Sica
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.
Antonello Merlino; Delia Picone; Anna Balsamo; Carmine Ercole; Filomena Sica
Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease.

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All Publications

2013: Andrea Pica; Irene Russo Krauss; Filomena Sica; Immacolata Castellano; Giuseppe Graziano; Francesco La Cara; Antonello Merlino
Effect of NaCl on the conformational stability of the thermophilic γ-glutamyltranspeptidase from Geobacillus thermodenitrificans: Implication for globular protein halotolerance.
Biochimica et biophysica acta 2013;1834(1):149-57.
2012: Irene Russo Krauss; Lelio Mazzarella; Antonello Merlino; Ettore Novellino; Antonio Randazzo; Filomena Sica
High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity.
Nucleic acids research 2012;40(16):8119-28.
2012: Antonello Merlino; Delia Picone; Anna Balsamo; Carmine Ercole; Filomena Sica
Chain termini cross-talk in the swapping process of bovine pancreatic ribonuclease.
Biochimie 2012;94(5):1108-18.
2012: Andrea Pica; Mosè Rossi; Irene Russo Krauss; Filomena Sica; Immacolata Castellano; Giuseppe Graziano; Francesco La Cara; Antonello Merlino
Exploring the unfolding mechanism of γ-glutamyltranspeptidases: the case of the thermophilic enzyme from Geobacillus thermodenitrificans.
Biochimica et biophysica acta 2012;1824(4):571-7.
2012: Antonello Merlino; Bianca Rossi; Irene Russo Krauss; Alberto De Vendittis; Emmanuele De Vendittis; Salvatore Marco; Alessandro Vergara; Filomena Sica
Identification of an active dimeric intermediate populated during the unfolding process of the cambialistic superoxide dismutase from Streptococcus mutans.
Biochimie 2012;94(3):768-75.
2012: Irene Russo Krauss; Filomena Sica; Carlo Andrea Mattia; Antonello Merlino
Increasing the X-ray Diffraction Power of Protein Crystals by Dehydration: The Case of Bovine Serum Albumin and a Survey of Literature Data.
International journal of molecular sciences 2012;13(3):3782-800.
2011: Irene Russo Krauss; Concetta Giancola; Lelio Mazzarella; Antonello Merlino; Antonio Randazzo; Filomena Sica
Thrombin-aptamer recognition: a revealed ambiguity.
Nucleic acids research 2011;39(17):7858-67.
2011: Fulvia Troise; Maria Monti; Antonello Merlino; Flora Cozzolino; Carmine Fedele; Filomena Sica; Piero Pucci; Giuseppe D'Alessio; Irene Russo Krauss; Claudia De Lorenzo
A novel ErbB2 epitope targeted by human antitumor immunoagents.
The FEBS journal 2011;278(7):1156-66.
2011: Antonello Merlino; Andrea Pica; Irene Russo Krauss; Antonella Albino; Emmanuele De Vendittis; Mariorosario Masullo; Alessandro Vergara; Filomena Sica
Improving Protein Crystal Quality by the Without-Oil Microbatch Method: Crystallization and Preliminary X-ray Diffraction Analysis of Glutathione Synthetase from Pseudoalteromonas haloplanktis.
International journal of molecular sciences 2011;12(9):6312-9.
2010: Antonello Merlino; Irene Russo Krauss; Immacolata Castellano; Emmanuele De Vendittis; Bianca Rossi; Maria Conte; Alessandro Vergara; Filomena Sica
Structure and flexibility in cold-adapted iron superoxide dismutases: the case of the enzyme isolated from Pseudoalteromonas haloplanktis.
Journal of structural biology 2010;172(3):343-52.
2010: Alessandro Vergara; Luigi Vitagliano; Antonello Merlino; Filomena Sica; Katia Marino; Cinzia Verde; Guido di Prisco; Lelio Mazzarella
An order-disorder transition plays a role in switching off the root effect in fish hemoglobins.
The Journal of biological chemistry 2010;285(42):32568-75.
2010: Irene Russo Krauss; Antonello Merlino; Antonio Randazzo; Lelio Mazzarella; Filomena Sica
Crystallization and preliminary X-ray analysis of the complex of human alpha-thrombin with a modified thrombin-binding aptamer.
Acta crystallographica. Section F, Structural biology and crystallization communications 2010;66(Pt 8):961-3.
2010: Antonello Merlino; Alessandro Vergara; Filomena Sica; Massimiliano Aschi; Andrea Amadei; Alfredo Di Nola; Lelio Mazzarella
Free-energy profile for CO binding to separated chains of human and Trematomus newnesi hemoglobin: insights from molecular dynamics simulations and perturbed matrix method.
The journal of physical chemistry. B 2010;114(20):7002-8.
2009: Antonello Merlino; Luigi Vitagliano; Barry D Howes; Cinzia Verde; Guido di Prisco; Giulietta Smulevich; Filomena Sica; Alessandro Vergara
Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins.
Biopolymers 2009;91(12):1117-25.
2009: Antonello Merlino; Irene Russo Krauss; Margherita Perillo; Carlo Andrea Mattia; Carmine Ercole; Delia Picone; Alessandro Vergara; Filomena Sica
Toward an antitumor form of bovine pancreatic ribonuclease: the crystal structure of three noncovalent dimeric mutants.
Biopolymers 2009;91(12):1029-37.
2009: Antonello Merlino; Filomena Sica; Alessandro Vergara; Lelio Mazzarella
The bis-histidyl complex in hemoproteins: A detailed conformational analysis of database protein structures and the case of Antarctic fish hemoglobins.
Marine genomics 2009;2(1):51-6.
2009: Antonello Merlino; Giovanna Avella; Sonia Di Gaetano; Angela Arciello; Renata Piccoli; Lelio Mazzarella; Filomena Sica
Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant.
Protein science : a publication of the Protein Society 2009;18(1):50-7.
2008: Antonello Merlino; Filomena Sica; Lelio Mazzarella; Adriana Zagari; Alessandro Vergara
Correlation between Raman and X-ray crystallography data of (Pro-Pro-Gly)10.
Biophysical chemistry 2008;137(1):24-7.
2008: Antonello Merlino; Carmine Ercole; Delia Picone; Elio Pizzo; Lelio Mazzarella; Filomena Sica
The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme.
Journal of molecular biology 2008;376(2):427-37.
2008: Antonello Merlino; Irene Russo Krauss; Immacolata Castellano; Emmanuele De Vendittis; Alessandro Vergara; Filomena Sica
Crystallization and preliminary x-ray diffraction studies of a psychrophilic iron superoxide dismutase from Pseudoalteromonas haloplanktis.
Protein and peptide letters 2008;15(4):415-8.
2007: Chiara Pastore; Marisa Franzese; Filomena Sica; Piero A Temussi; Annalisa Pastore
Understanding the binding properties of an unusual metal-binding protein--a study of bacterial frataxin.
The FEBS journal 2007;274(16):4199-210.
2007: Antonello Merlino; Filomena Sica; Lelio Mazzarella
Approximate values for force constant and wave number associated with a low-frequency concerted motion in proteins can be evaluated by a comparison of X-ray structures.
The journal of physical chemistry. B 2007;111(19):5483-6.
2005: Antonello Merlino; Lelio Mazzarella; Anna Carannante; Anna Di Fiore; Alberto Di Donato; Eugenio Notomista; Filomena Sica
The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants.
The Journal of biological chemistry 2005;280(18):17953-60.
2005: Delia Picone; Anna Di Fiore; Carmine Ercole; Marisa Franzese; Filomena Sica; Simona Tomaselli; Lelio Mazzarella
The role of the hinge loop in domain swapping. The special case of bovine seminal ribonuclease.
The Journal of biological chemistry 2005;280(14):13771-8.
2004: Filomena Sica; Anna Di Fiore; Antonello Merlino; Lelio Mazzarella
Structure and stability of the non-covalent swapped dimer of bovine seminal ribonuclease: an enzyme tailored to evade ribonuclease protein inhibitor.
The Journal of biological chemistry 2004;279(35):36753-60.
2004: Antonello Merlino; Luigi Vitagliano; Filomena Sica; Adriana Zagari; Lelio Mazzarella
Population shift vs induced fit: the case of bovine seminal ribonuclease swapping dimer.
Biopolymers 2004;73(6):689-95.
2003: Luciana Esposito; Ilaria Bruno; Filomena Sica; Carlo Antonio Raia; Antonietta Giordano; Mosè Rossi; Lelio Mazzarella; Adriana Zagari
Crystal structure of a ternary complex of the alcohol dehydrogenase from Sulfolobus solfataricus.
Biochemistry 2003;42(49):14397-407.
2003: Rita Berisio; Filomena Sica; Claudia De Lorenzo; Anna Di Fiore; Renata Piccoli; Adriana Zagari; Lelio Mazzarella
Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease.
FEBS letters 2003;554(1-2):105-10.
2003: Filomena Sica; Anna Di Fiore; Adriana Zagari; Lelio Mazzarella
The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative.
Proteins 2003;52(2):263-71.
2003: Luciana Esposito; Ilaria Bruno; Filomena Sica; Carlo Antonio Raia; Antonietta Giordano; Mosè Rossi; Lelio Mazzarella; Adriana Zagari
Structural study of a single-point mutant of Sulfolobus solfataricus alcohol dehydrogenase with enhanced activity.
FEBS letters 2003;539(1-3):14-8.
2002: Luciana Esposito; Filomena Sica; Carlo Antonio Raia; Antonietta Giordano; Mosè Rossi; Lelio Mazzarella; Adriana Zagari
Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus at 1.85 A resolution.
Journal of molecular biology 2002;318(2):463-77.
2002: Rita Berisio; Filomena Sica; VS Lamzin; KS Wilson; Adriana Zagari; Lelio Mazzarella
Atomic resolution structures of ribonuclease A at six pH values.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 3):441-50.
2001: Luigi Vitagliano; Mariorosario Masullo; Filomena Sica; Adriana Zagari; Vincenzo Bocchini
The crystal structure of Sulfolobus solfataricus elongation factor 1alpha in complex with GDP reveals novel features in nucleotide binding and exchange.
The EMBO journal 2001;20(19):5305-11.
2000: Luciana Esposito; Luigi Vitagliano; Filomena Sica; Giosué Sorrentino; Adriana Zagari; Lelio Mazzarella
The ultrahigh resolution crystal structure of ribonuclease A containing an isoaspartyl residue: hydration and sterochemical analysis.
Journal of molecular biology 2000;297(3):713-32.
1999: Luigi Vitagliano; Salvatore Adinolfi; Filomena Sica; Antonello Merlino; Adriana Zagari; Lelio Mazzarella
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease.
Journal of molecular biology 1999;293(3):569-77.
1999: Rita Berisio; VS Lamzin; Filomena Sica; KS Wilson; Adriana Zagari; Lelio Mazzarella
Protein titration in the crystal state.
Journal of molecular biology 1999;292(4):845-54.
1998: Luigi Vitagliano; Salvatore Adinolfi; A Riccio; Filomena Sica; Adriana Zagari; Lelio Mazzarella
Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine.
Protein science : a publication of the Protein Society 1998;7(8):1691-9.
1998: Luciana Esposito; Filomena Sica; Giosué Sorrentino; Rita Berisio; Luigi Carotenuto; Antonietta Giordano; Carlo Antonio Raia; Mosè Rossi; VS Lamzin; KS Wilson; Adriana Zagari
Protein crystal growth in the Advanced Protein Crystallization Facility on the LMS mission: a comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 3):386-90.
1996: Salvatore Adinolfi; Renata Piccoli; Filomena Sica; Lelio Mazzarella
BS-RNase tetramers: an example of domain-swapped oligomers.
FEBS letters 1996;398(2-3):326-32.
1996: S Capasso; Alberto Di Donato; Luciana Esposito; Filomena Sica; Giosué Sorrentino; Luigi Vitagliano; Adriana Zagari; Lelio Mazzarella
Deamidation in proteins: the crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67.
Journal of molecular biology 1996;257(3):492-6.
1996: D Demasi; S Capasso; Filomena Sica; Adriana Zagari
Conformationally restrained peptides: crystal structure of tert-butyloxycarbonyl-L-alanyl-D-alanyl-D-aminosuccinyl-glycyl-L- alanine methyl ester.
International journal of peptide and protein research 1996;47(4):227-30.
1995: S Capasso; Filomena Sica; Lelio Mazzarella; Gianfranco Balboni; Remo Guerrini; Severo Salvadori
Acid catalysis in the formation of dioxopiperazines from peptides containing tetrahydroisoquinoline-3-carboxylic acid at position 2.
International journal of peptide and protein research 1995;45(6):567-73.
1994: Adriana Zagari; Filomena Sica; G Scarano; Luigi Vitagliano; Vincenzo Bocchini
Crystallization of a hyperthermophilic archaeal elongation factor 1 alpha.
Journal of molecular biology 1994;242(2):175-7.
1994: Adriana Zagari; L Savino; S Capasso; Filomena Sica; Lelio Mazzarella
Crystallization and preliminary X-ray analysis of the river buffalo (Bubalus bubalis L.) BB phenotype carbonmonoxyhaemoglobin.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 5):778-80.
1994: Filomena Sica; D Demasi; D L Mazzarella; Adriana Zagari; S Capasso; L H Pearl; Sabato D'Auria; Carlo Antonio Raia; M Rossi
Elimination of twinning in crystals of Sulfolobus sofataricus alcohol dehydrogenase holo-enzyme by growth in agarose gels.
Acta crystallographica. Section D, Biological crystallography 1994;50(Pt 4):508-11.
1993: Laurence H Pearl; D Demasi; A M Hemmings; Filomena Sica; Lelio Mazzarella; Carlo Antonio Raia; Sabato D'Auria; M Rossi
Crystallization and preliminary X-ray analysis of an NAD(+)-dependent alcohol dehydrogenase from the extreme thermophilic archaebacterium Sulfolobus solfataricus.
Journal of molecular biology 1993;229(3):782-4.
1992: S Capasso; C A Mattia; Lelio Mazzarella; Filomena Sica; Adriana Zagari
Conformation of aminosuccinyl dipeptides Ac-L-X-L-Asu-NMe from empirical energy calculations.
Peptide research 1992;5(6):325-30.
1992: S Capasso; Lelio Mazzarella; Filomena Sica; Adriana Zagari; G Cascarano; C Giacovazzo
Solid-state conformations of aminosuccinyl peptides: structure of tert-butyloxycarbonyl-L-prolyl-L-aminosuccinyl-glycyl-L-alanine methyl ester (Boc-L-Pro-L-Asu-Gly-L-Ala-OMe). A case of pseudo-translational symmetry.
Acta crystallographica. Section B, Structural science 1992;48 ( Pt 3)():285-90.
1990: S Capasso; C A Mattia; Lelio Mazzarella; Filomena Sica; Adriana Zagari
Conformation of aminosuccinyl dipeptides Ac-Asu-X-NHMe from empirical energy calculations.
Peptide research 1990;3(6):262-70.
1989: S Capasso; Lelio Mazzarella; Filomena Sica; Adriana Zagari
Deamidation via cyclic imide in asparaginyl peptides.
Peptide research 1989;2(2):195-200.
1989: S Capasso; Lelio Mazzarella; Filomena Sica; Adriana Zagari
Solid-state conformations of aminosuccinyl peptides: crystal structure of tert-butyloxycarbonyl-L-leucyl-L-aminosuccinyl-L-phenylalaninami de.
Biopolymers 1989;28(1):139-47.
1988: Patrizia Galletti; Diego Ingrosso; Caterina Manna; Filomena Sica; S Capasso; P Pucci; G Marino
Enzymatic methyl esterification of synthetic tripeptides: structural requirements of the peptide substrate. Detection of the reaction products by fast-atom-bombardment mass spectrometry.
European journal of biochemistry / FEBS 1988;177(1):233-9.
1988: Lelio Mazzarella; I Schön; Filomena Sica; Adriana Zagari
N-benzyloxycarbonyl-L-aminosuccinyl-L-phenylalaninamide (Z-L-Asu-L-Phe-NH2).
Acta crystallographica. Section C, Crystal structure communications 1988;44 ( Pt 5)():880-2.
1987: S Capasso; Filomena Sica; Adriana Zagari
Identification of aminosuccinyl residues in peptides by second-derivative ultraviolet spectrometry.
Peptides 1987;8(5):791-6.
1984: S Capasso; Lelio Mazzarella; Filomena Sica; Adriana Zagari
Type II' beta-bend conformation of tert.-butyloxycarbonyl-L-amino-succinyl-L-alanyl-glycine methyl ester in the solid state.
International journal of peptide and protein research 1984;24(6):588-96.