FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Salvatore Siciliano

Research Profile

Chemicals & Drugs

Concepts & Ideas

Structure-Activity Relationship

Anatomy

Living Beings

Physiology

Transfection

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
Carsten Schröder; Richard N Pierson III; Bao-Ngoc H Nguyen; Douglas W Kawka; Laurence B Peterson; Guosheng Wu; Tianshu Zhang; Martin S Springer; Salvatore J Siciliano; Susan Iliff; Julia Ayala; Min Lu; John S Mudgett; Kathy Lyons; Sander G Mills; Geraldine G Miller; Irwin I Singer; Agnes M Azimzadeh; Julie A DeMartino
CCR5 blockade modulates inflammation and alloimmunity in primates.
Gregory W King; Gary S Kath; Salvatore J Siciliano; Neal Simpson; Prakash Masurekar; Jan Sigmund; Jon Polishook; Stephen Skwish; Gerald F Bills; Olga Genilloud; Fernando Peláez; Jesus Martín; Claude Dufresne
Automated agar plate streaker: a linear plater on Society for Biomolecular Sciences standard plates.
K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Salvatore Siciliano (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2007: Carsten Schröder; Richard N Pierson III; Bao-Ngoc H Nguyen; Douglas W Kawka; Laurence B Peterson; Guosheng Wu; Tianshu Zhang; Martin S Springer; Salvatore J Siciliano; Susan Iliff; Julia Ayala; Min Lu; John S Mudgett; Kathy Lyons; Sander G Mills; Geraldine G Miller; Irwin I Singer; Agnes M Azimzadeh; Julie A DeMartino
CCR5 blockade modulates inflammation and alloimmunity in primates.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2289-99.
2006: Gregory W King; Gary S Kath; Salvatore J Siciliano; Neal Simpson; Prakash Masurekar; Jan Sigmund; Jon Polishook; Stephen Skwish; Gerald F Bills; Olga Genilloud; Fernando Peláez; Jesus Martín; Claude Dufresne
Automated agar plate streaker: a linear plater on Society for Biomolecular Sciences standard plates.
Journal of biomolecular screening 2006;11(6):704-11.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Charles G Caldwell; Ping Chen; Paul E Finke; Bryan Oates; Malcolm MacCoss; Sander G Mills; Julie A DeMartino; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Gloria Y Kwei; Anthony Carella; Gwen Carver; Renee Danzeisen; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists.
Bioorganic & medicinal chemistry letters 2004;14(13):3589-93.
2004: K Shankaran; Karla L Donnelly; Shrenik K Shah; Ravindra N Guthikonda; Malcolm MacCoss; Sander G Mills; Sandra L Gould; Lorraine Malkowitz; Salvatore J Siciliano; Martin S Springer; Anthony Carella; Gwen Carver; Daria J Hazuda; Karen Holmes; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini; William A Schleif
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.
Bioorganic & medicinal chemistry letters 2004;14(13):3419-24.
2004: Hiranthi Jayasuriya; Kithsiri B Herath; John G Ondeyka; Jon D Polishook; Gerald F Bills; Anne W Dombrowski; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; Manuel Sanchez; Ziqiang Guan; Suroojnauth Tiwari; Dennis W Stevenson; Robert P Borris; Sheo B Singh
Isolation and structure of antagonists of chemokine receptor (CCR5).
Journal of natural products 2004;67(6):1036-8.
2004: Min Shu; Jennifer L Loebach; Kerry A Parker; Sander G Mills; Kevin Chapman; Dong-Ming Shen; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Jerry Di Salvo; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Bioorganic & medicinal chemistry letters 2004;14(4):947-52.
2004: Dong-Ming Shen; Min Shu; Christopher A Willoughby; Shrenik Shah; Christopher L Lynch; Jeffrey J Hale; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Kathryn Lyons; James V Pivnichny; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorganic & medicinal chemistry letters 2004;14(4):941-5.
2004: Dong-Ming Shen; Min Shu; Sander G Mills; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Gloria Y Kwei; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael D Miller; Emilio A Emini
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 1: Discovery and SAR study of 4-pyrazolylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2004;14(4):935-9.
2003: Ronald S Veazey; Per Johan Klasse; Thomas J Ketas; Jacqueline D Reeves; Michael Piatak; Kevin Kunstman; Shawn E Kuhmann; Preston A Marx; Jeffrey D Lifson; Jason Dufour; Megan Mefford; Ivona Pandrea; Steven Wolinsky; Robert W Doms; Julie A DeMartino; Salvatore J Siciliano; Kathy Lyons; Martin S Springer; John P Moore
Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
The Journal of experimental medicine 2003;198(10):1551-62.
2003: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Paul E Finke; Charles G Caldwell; Sander G Mills; Malcolm MacCoss; Dong-Ming Shen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Organic letters 2003;5(14):2473-5.
2003: Christopher A Willoughby; Keith G Rosauer; Jeffrey J Hale; Richard J Budhu; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4 Trisubstituted pyrrolidine CCR5 receptor antagonists bearing 4-aminoheterocycle substituted piperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(3):427-31.
2003: Christopher L Lynch; Christopher A Willoughby; Jeffrey J Hale; Edward J Holson; Richard J Budhu; Amy L Gentry; Keith G Rosauer; Charles G Caldwell; Ping Chen; Sander G Mills; Malcolm MacCoss; Scott Berk; Liya Chen; Kevin Chapman; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorganic & medicinal chemistry letters 2003;13(1):119-23.
2002: Christopher L Lynch; Jeffrey J Hale; Richard J Budhu; Amy L Gentry; Sander G Mills; Kevin Chapman; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorganic & medicinal chemistry letters 2002;12(20):3001-4.
2002: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 3: polar functionality and its effect on anti-HIV-1 activity.
Bioorganic & medicinal chemistry letters 2002;12(20):2997-3000.
2002: Christopher L Lynch; Amy L Gentry; Jeffrey J Hale; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Margaret A Cascieri; George A Doss; Anthony Carella; Gwen Carver; Karen Holmes; William A Schleif; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; Emilio A Emini
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorganic & medicinal chemistry letters 2002;12(4):677-9.
2001: Jeffrey J Hale; Richard J Budhu; E B Holson; Paul E Finke; Bryan Oates; Sander G Mills; Malcolm MacCoss; Sandra L Gould; Julie A DeMartino; Martin S Springer; Salvatore J Siciliano; Lorraine Malkowitz; William A Schleif; Daria J Hazuda; Michael Miller; Joseph Kessler; Renee Danzeisen; Karen Holmes; Janet Lineberger; Anthony Carella; Gwen Carver; Emilio A Emini
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 2: lead optimization affording selective, orally bioavailable compounds with potent anti-HIV activity.
Bioorganic & medicinal chemistry letters 2001;11(20):2741-5.
2001: Jeffrey J Hale; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Salvatore J Siciliano; Sandra L Gould; Julie A DeMartino; Martin S Springer
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 1: discovery of the pyrrolidine scaffold and determination of its stereochemical requirements.
Bioorganic & medicinal chemistry letters 2001;11(11):1437-40.
2001: Irwin I Singer; S Scott; Douglas W Kawka; J Chin; Bruce L Daugherty; Julie A DeMartino; J DiSalvo; Sandra L Gould; Janet Lineberger; Lorraine Malkowitz; M D Miller; L Mitnaul; Salvatore J Siciliano; Mary Jo Staruch; HR Williams; Hans Zweerink; Martin S Springer
CCR5, CXCR4, and CD4 are clustered and closely apposed on microvilli of human macrophages and T cells.
Journal of virology 2001;75(8):3779-90.
2001: Paul E Finke; Laura C Meurer; Bryan Oates; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 2: structure-activity relationships for substituted 2-Aryl-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):265-70.
2001: C P Dorn; Paul E Finke; Bryan Oates; Richard J Budhu; Sander G Mills; Malcolm MacCoss; Lorraine Malkowitz; Martin S Springer; Bruce L Daugherty; Sandra L Gould; Julie A DeMartino; Salvatore J Siciliano; Anthony Carella; Gwen Carver; Karen Holmes; Renee Danzeisen; Daria J Hazuda; Joseph Kessler; Janet Lineberger; Michael Miller; William A Schleif; Emilio A Emini
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. part 1: discovery and initial structure-activity relationships for 1 -amino-2-phenyl-4-(piperidin-1-yl)butanes.
Bioorganic & medicinal chemistry letters 2001;11(2):259-64.
1999: Salvatore J Siciliano; Shawn E Kuhmann; Y Weng; Navid Madani; Martin S Springer; Janet Lineberger; Renee Danzeisen; M D Miller; Michael P Kavanaugh; Julie A DeMartino; David Kabat
A critical site in the core of the CCR5 chemokine receptor required for binding and infectivity of human immunodeficiency virus type 1.
The Journal of biological chemistry 1999;274(4):1905-13.
1998: Y Weng; Salvatore J Siciliano; K E Waldburger; A Sirotina-Meisher; Mary Jo Staruch; Bruce L Daugherty; Sandra L Gould; Martin S Springer; Julie A DeMartino
Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors.
The Journal of biological chemistry 1998;273(29):18288-91.
1996: Bruce L Daugherty; Salvatore J Siciliano; Julie A DeMartino; L Malkowitz; A Sirotina; Martin S Springer
Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
The Journal of experimental medicine 1996;183(5):2349-54.
1995: Julie A DeMartino; Z D Konteatis; Salvatore J Siciliano; G Van Riper; D J Underwood; P A Fischer; Martin S Springer
Arginine 206 of the C5a receptor is critical for ligand recognition and receptor activation by C-terminal hexapeptide analogs.
The Journal of biological chemistry 1995;270(27):15966-9.
1994: Z D Konteatis; Salvatore J Siciliano; G Van Riper; C J Molineaux; S Pandya; P Fischer; H Rosen; R A Mumford; Martin S Springer
Development of C5a receptor antagonists. Differential loss of functional responses.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(9):4200-5.
1994: Julie A DeMartino; G Van Riper; Salvatore J Siciliano; C J Molineaux; Z D Konteatis; H Rosen; Martin S Springer
The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.
The Journal of biological chemistry 1994;269(20):14446-50.
1994: Salvatore J Siciliano; T E Rollins; Julie A DeMartino; Z Konteatis; L Malkowitz; G Van Riper; S Bondy; H Rosen; Martin S Springer
Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1214-8.
1993: G Van Riper; Salvatore J Siciliano; P A Fischer; R Meurer; Martin S Springer; H Rosen
Characterization and species distribution of high affinity GTP-coupled receptors for human rantes and monocyte chemoattractant protein 1.
The Journal of experimental medicine 1993;177(3):851-6.
1992: T J Lanza; P L Durette; T Rollins; Salvatore J Siciliano; D N Cianciarulo; S V Kobayashi; C G Caldwell; Martin S Springer; William K Hagmann
Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding.
Journal of medicinal chemistry 1992;35(2):252-8.
1991: T E Rollins; Salvatore J Siciliano; S Kobayashi; D N Cianciarulo; V Bonilla-Argudo; K Collier; Martin S Springer
Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-Gi complex.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(3):971-5.
1990: Salvatore J Siciliano; T E Rollins; Martin S Springer
Interaction between the C5a receptor and Gi in both the membrane-bound and detergent-solubilized states.
The Journal of biological chemistry 1990;265(32):19568-74.
1988: T E Rollins; Salvatore J Siciliano; Martin S Springer
Solubilization of the functional C5a receptor from human polymorphonuclear leukocytes.
The Journal of biological chemistry 1988;263(1):520-6.