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Zahid Siddik
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41
Khokhar, Abdul
12
Bull, Joan
11
Strebel, Frederick
8
Newman, Robert
7
Stephens, Clifton
5
Whitmire, Kenton
4
Perez-Soler, Roman
4
Mills, Gordon
3
Kuang, Jian
3
Klostergaard, Jim
3
He, Guangan
3
Huang, Zaifeng
3
Zhang, Yanping
3
Shamsuddin, S
2
Song, Im-Sook
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All Publications
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2009: Mangala Lingegowda S; Zuzel Vesna; Schmandt Rosemarie; Leshane Erik S; Halder Jyotsna B; Armaiz-Pena Guillermo N; Spannuth Whitney A; Tanaka Takemi; Shahzad Mian M K; Lin Yvonne G; Nick Alpa M; Danes Christopher G; Lee Jeong-Won; Jennings Nicholas B; Vivas-Mejia Pablo E; Wolf Judith K; Coleman Robert L; Siddik Zahid H; Lopez-Berestein Gabriel; Lutsenko Svetlana; Sood Anil K
Therapeutic Targeting of ATP7B in Ovarian Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3770-80.
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2008: Chen Helen H W; Song Im-Sook; Hossain Anwar; Choi Min-Koo; Yamane Yoshiaki; Liang Zheng D; Lu Jia; Wu Lily Y-H; Siddik Zahid H; Klomp Leo W J; Savaraj Niramol; Kuo Macus Tien
Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1.
Molecular pharmacology 2008;74(3):697-704.
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2007: Lu Yang; Li Xinqun; Liang Ke; Luwor Rodney; Siddik Zahid H; Mills Gordon B; Mendelsohn John; Fan Zhen
Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab.
Cancer research 2007;67(17):8240-7.
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2006: He G; Kuang J; Huang Z; Koomen J; Kobayashi R; Khokhar A R; Siddik Z H
Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21.
British journal of cancer 2006;95(11):1514-24.
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2005: He Guangan; Siddik Zahid H; Huang Zaifeng; Wang Ruoning; Koomen John; Kobayashi Ryuji; Khokhar Abdul R; Kuang Jian
Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities.
Oncogene 2005;24(18):2929-43.
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2005: Ali Mohammad S; Khan S Rounaq Ali; Ojima H; Guzman Ilse Y; Whitmire Kenton H; Siddik Zahid H; Khokhar Abdul R
Model platinum nucleobase and nucleoside complexes and antitumor activity: X-ray crystal structure of [PtIV(trans-1R,2R-diaminocyclohexane)trans-(acetate)2(9-ethylguanine)Cl]NO3.H2O.
Journal of inorganic biochemistry 2005;99(3):795-804.
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2005: Mujoo Kalpana; Watanabe Masayuki; Khokhar Abdul R; Siddik Zahid H
Increased sensitivity of a metastatic model of prostate cancer to a novel tetravalent platinum analog.
The Prostate 2005;62(1):91-100.
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2004: Song Im-Sook; Savaraj Niramol; Siddik Zahid H; Liu Peiman; Wei Yingjie; Wu Chun Jing; Kuo Macus Tien
Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells.
Molecular cancer therapeutics 2004;3(12):1543-9.
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2003: Mujoo Kalpana; Watanabe Masayuki; Nakamura Junichi; Khokhar Abdul R; Siddik Zahid H
Status of p53 phosphorylation and function in sensitive and resistant human cancer models exposed to platinum-based DNA damaging agents.
Journal of cancer research and clinical oncology 2003;129(12):709-18.
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2003: Siddik Zahid H
Cisplatin: mode of cytotoxic action and molecular basis of resistance.
Oncogene 2003;22(47):7265-79.
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2003: Verschraegen C F; Kumagai S; Davidson R; Feig B; Mansfield P; Lee S J; Maclean D S; Hu W; Khokhar A R; Siddik Z H
Phase I clinical and pharmacological study of intraperitoneal cis-bis-neodecanoato( trans- R, R-1, 2-diaminocyclohexane)-platinum II entrapped in multilamellar liposome vesicles.
Journal of cancer research and clinical oncology 2003;129(10):549-55.
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2003: Mansouri Abdellah; Ridgway Lon D; Korapati Anita L; Zhang Qingxiu; Tian Ling; Wang Yibin; Siddik Zahid H; Mills Gordon B; Claret François X
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
The Journal of biological chemistry 2003;278(21):19245-56.
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2003: Mukhopadhyay Uday; Thurston John; Whitmire Kenton H; Siddik Zahid H; Khokhar Abdul R
Preparation, characterization, and antitumor activity of new cisplatin analogues with 1-methyl-4-(methylamino)piperidine: crystal structure of [PtII(1-methyl-4-(methylamino) piperidine)(oxalate)].
Journal of inorganic biochemistry 2003;94(1-2):179-85.
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2002: Siddik Zahid H
Biochemical and molecular mechanisms of cisplatin resistance.
Cancer treatment and research 2002;112():263-84.
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2001: Kuang J; He G; Huang Z; Khokhar A R; Siddik Z H
Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(11):3629-39.
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2000: Ali Khan S R; Huang S; Shamsuddin S; Inutsuka S; Whitmire K H; Siddik Z H; Khokhar A R
Synthesis, characterization and cytotoxicity of new platinum(IV) axial carboxylate complexes: crystal structure of potential antitumor agent [PtIV(trans-1R,2R-diaminocyclohexane)trans(acetate)2Cl2].
Bioorganic & medicinal chemistry 2000;8(3):515-21.
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2000: Donato N J; Perez M; Kang H; Siddik Z H; Ling Y H; Perez-Soler R
EGF receptor and p21WAF1 expression are reciprocally altered as ME-180 cervical carcinoma cells progress from high to low cisplatin sensitivity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(1):193-202.
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1999: Furui T; LaPushin R; Mao M; Khan H; Watt S R; Watt M A; Lu Y; Fang X; Tsutsui S; Siddik Z H; Bast R C; Mills G B
Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(12):4308-18.
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1999: Ali M S; Whitmire K H; Toyomasu T; Siddik Z H; Khokhar A R
Preparation, characterization, and antitumor activity of new cisplatin analogs with homopiperazines: crystal structure of [PtII(1-methylhomopiperazine)(methylmalonato)].2H2O.
Journal of inorganic biochemistry 1999;77(3-4):231-8.
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1999: Siddik Z H; Hagopian G S; Thai G; Tomisaki S; Toyomasu T; Khokhar A R
Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance.
Journal of inorganic biochemistry 1999;77(1-2):65-70.
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1999: Hagopian G S; Mills G B; Khokhar A R; Bast R C; Siddik Z H
Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV).
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(3):655-63.
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1998: Yoshida M; Khokhar A R; Siddik Z H
Cytotoxicity and tolerance to DNA adducts of alicyclic mixed amine platinum(II) homologs in tumor models sensitive and resistant to cisplatin or tetraplatin.
Oncology reports 1998;5(5):1281-7.
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1998: Shamsuddin S; Santillan C C; Stark J L; Whitmire K H; Siddik Z H; Khokhar A R
Synthesis, characterization, and antitumor activity of new platinum(IV) trans-carboxylate complexes: crystal structure of [Pt(cis-1,4-DACH)trans-(acetate)2Cl2]
Journal of inorganic biochemistry 1998;71(1-2):29-35.
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1998: Siddik Z H; Mims B; Lozano G; Thai G
Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line.
Cancer research 1998;58(4):698-703.
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1997: Kudelka A P; Siddik Z H; Tresukosol D; Edwards C L; Freedman R S; Madden T L; Rastogi R; Hord M; Kim E E; Tornos C; Mante R; Kavanagh J J
A phase II and pharmacokinetic study of enloplatin in patients with platinum refractory advanced ovarian carcinoma.
Anti-cancer drugs 1997;8(7):649-56.
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1997: Perez-Soler R; Shin D M; Siddik Z H; Murphy W K; Huber M; Lee S J; Khokhar A R; Hong W K
Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(3):373-9.
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1997: Khokhar A R; al-Baker S; Shamsuddin S; Siddik Z H
Chemical and biological studies on a series of novel (trans-(1R,2R)-, trans-(1S,2S)-, and cis-1,2-diaminocyclohexane)platinum(IV) carboxylate complexes.
Journal of medicinal chemistry 1997;40(1):112-6.
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1996: Shamsuddin S; Takahashi I; Siddik Z H; Khokhar A R
Synthesis, characterization, and antitumor activity of a series of novel cisplatin analogs with cis-1,4-diaminocyclohexane as nonleaving amine group.
Journal of inorganic biochemistry 1996;61(4):291-301.
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1996: Klostergaard J; Leroux M E; Hsu H A; Hsi B P; Siddik Z H; Danhauser L L; Tomasovi S P
Multi-chemothermoimmunotherapy for human colon adenocarcinoma in vitro.
Cancer chemotherapy and pharmacology 1996;37(3):235-41.
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1995: Davidson B S; Izzo F; Cromeens D M; Stephens L C; Siddik Z H; Curley S A
Collagen matrix cisplatin prevents local tumor growth after margin-positive resection.
The Journal of surgical research 1995;58(6):618-24.
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1995: Wondergem J; Strebel F R; Stephens L C; Siddik Z H; Bull J M
Chronic effect of whole-body hyperthermia combined simultaneously with cis-diamminedichloroplatinum (II) on normal tissue in rat.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1995;11(1):37-47.
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1994: Siddik Z H; Thai G; Yoshida M; Zhang Y P; Khokhar A R
Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo.
Anti-cancer drug design 1994;9(6):495-509.
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1994: Yoshida M; Khokhar A R; Siddik Z H
Circumvention of platinum resistance: structure-activity relationship for homologous series of ammine/amine platinum(II) complexes in L1210 cell lines.
Anti-cancer drug design 1994;9(5):425-34.
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1994: Yoshida M; Khokhar A R; Siddik Z H
Axial ligands and alicyclic ring size modulate the activity and biochemical pharmacology of ammine/cycloalkylamine-platinum(IV) complexes in tumor cells resistant to cis-diamminedichloroplatinum(II) or trans-1R,2R-1S,2S-diaminocyclohexanetetrachloroplatinum(IV).
Cancer research 1994;54(17):4691-7.
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1994: Yoshida M; Khokhar A R; Kido Y; Ali-Osman F; Siddik Z H
Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin.
Biochemical pharmacology 1994;48(4):793-9.
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1994: Yoshida M; Khokhar A R; Siddik Z H
Biochemical pharmacology of homologous alicyclic mixed amine platinum(II) complexes in sensitive and resistant tumor cell lines.
Cancer research 1994;54(13):3468-73.
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1994: Kido Y; Khokhar A R; Siddik Z H
Glutathione-mediated modulation of tetraplatin activity against sensitive and resistant tumor cells.
Biochemical pharmacology 1994;47(9):1635-42.
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1994: Siddik Z H; al-Baker S; Thai G; Khokhar A R
Modulatory effect of axial and equatorial ligands on antitumor activities of trans-1R,2R-diaminocyclohexane platinum(IV) complexes.
Anti-cancer drug design 1994;9(2):139-51.
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1994: Khokhar A R; al-Baker S; Siddik Z H
Synthesis and antitumor activity of 1,2-diaminocyclohexane platinum(IV) complexes.
Journal of inorganic biochemistry 1994;54(1):39-47.
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1994: Khokhar A R; Xu Q; Siddik Z H
Synthesis, characterization, and antitumor activity of amine platinum(II) and (IV) tellurate complexes.
Journal of inorganic biochemistry 1994;53(4):295-301.
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1994: Kido Y; Khokhar A R; Yoshida M; Thai G W; Siddik Z H
Pharmacokinetics of tetraplatin administered intraperitoneally with reduced glutathione in mice.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):312-7.
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1994: Siddik Z H; al-Baker S; Thai G; Khokhar A R
Antitumor activity of isomeric 1,2-diaminocyclohexane platinum(IV) complexes.
Journal of cancer research and clinical oncology 1994;120(7):409-14.
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1994: Ohno S; Siddik Z H; Kido Y; Zwelling L A; Bull J M
Thermal enhancement of drug uptake and DNA adducts as a possible mechanism for the effect of sequencing hyperthermia on cisplatin-induced cytotoxicity in L1210 cells.
Cancer chemotherapy and pharmacology 1994;34(4):302-6.
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1994: Yoshida M; Khokhar A R; Zhang Y P; Thai G; Siddik Z H
Kinetics of tissue disposition of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin in mice bearing FSaIIC tumors.
Cancer chemotherapy and pharmacology 1994;35(1):38-44.
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1994: Siddik Z H; Thai G; Yoshida M; Zhang Y P; Khokhar A R
Ammine/amine platinum (II) complexes effective in vivo against murine tumors sensitive or resistant to cisplatin and tetraplatin.
Journal of cancer research and clinical oncology 1994;120(10):571-7.
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1993: Kido Y; Khokhar A R; al-Baker S; Siddik Z H
Modulation of cytotoxicity and cellular pharmacology of 1,2-diaminocyclohexane platinum (IV) complexes mediated by axial and equatorial ligands.
Cancer research 1993;53(19):4567-72.
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1993: Ohno S; Strebel F R; Stephens L C; Siddik Z H; Baba H; Makino M; Khokhar A R; Bull J M
Haematological toxicity of carboplatin and cisplatin combined with whole body hyperthermia in rats.
British journal of cancer 1993;68(3):469-74.
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1993: Khokhar A R; Deng Y; al-Baker S; Yoshida M; Siddik Z H
Synthesis and antitumor activity of ammine/amine platinum(II) and (IV) complexes.
Journal of inorganic biochemistry 1993;51(3):677-87.
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1993: Khokhar A R; Deng Y; Kido Y; Siddik Z H
Preparation, characterization, and antitumor activity of new ethylenediamine platinum(IV) complexes containing mixed carboxylate ligands.
Journal of inorganic biochemistry 1993;50(2):79-87.
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1993: Kido Y; Khokhar A R; Siddik Z H
Differential cytotoxicity, uptake and DNA binding of tetraplatin and analogous isomers in sensitive and resistant cancer cell lines.
Anti-cancer drugs 1993;4(2):251-8.
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1993: Wondergem J; Siddik Z H; Strebel F R; Bull J M
Effect of whole body hyperthermia on cis-diamminedichloroplatinum (II)-induced antitumour activity and tissue Pt-distribution: do anaesthetics influence the therapeutic ratio?
European journal of cancer (Oxford, England : 1990) 1993;29A(4):549-54.
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1993: Siddik Z H; al-Baker S; Burditt T L; Khokhar A R
Differential antitumor activity and toxicity of isomeric 1,2-diaminocyclohexane platinum (II) complexes.
Journal of cancer research and clinical oncology 1993;120(1-2):12-6.
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1993: Curley S A; Stone D L; Fuhrman G M; Hohn D C; Siddik Z H; Newman R A
Increased doxorubicin levels in hepatic tumors with reduced systemic drug exposure achieved with complete hepatic venous isolation and extracorporeal chemofiltration.
Cancer chemotherapy and pharmacology 1993;33(3):251-7.
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1992: Klostergaard J; Leroux E; Siddik Z H; Khodadadian M; Tomasovic S P
Enhanced sensitivity of human colon tumor cell lines in vitro in response to thermochemoimmunotherapy.
Cancer research 1992;52(19):5271-7.
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1992: Kido Y; Khokhar A R; Siddik Z H
Pharmacokinetics of intravenously injected [3H]tetrachloro(D,L-trans)1,2-diaminocyclohexane platinum (IV) (tetraplatin) in mice.
Drug metabolism and disposition: the biological fate of chemicals 1992;20(5):673-8.
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1992: Ohno S; Strebel F R; Stephens L C; Siddik Z H; Makino M; Klostergaard J; Tomasovic S P; Khokhar A R; Bull J M
Increased therapeutic efficacy induced by tumor necrosis factor alpha combined with platinum complexes and whole-body hyperthermia in rats.
Cancer research 1992;52(15):4096-101.
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1992: Khokhar A R; Xu Q; Newman R A; Kido Y; Siddik Z H
Synthesis, characterization, and antitumor activity of new chloroethylamine platinum complexes.
Journal of inorganic biochemistry 1992;45(3):211-9.
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1992: Vadiei K; Siddik Z H; Khokhar A R; al-Baker S; Sampedro F; Perez-Soler R
Pharmacokinetics of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) and cisplatin given i.v. and i.p. in the rat.
Cancer chemotherapy and pharmacology 1992;30(5):365-9.
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1991: Wondergem J; Stephens L C; Strebel F R; Baba H; Ohno S; Siddik Z H; Newman R A; Bull J M
Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues.
Cancer research 1991;51(13):3559-67.
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1991: Khokhar A R; Xu Q Y; Newman R A; Siddik Z H
Preparation, characterization, and antitumor activity of water-soluble aminoalkanol platinum(II) complexes.
Journal of inorganic biochemistry 1991;43(1):57-63.
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1991: Baba H; Stephens L C; Strebel F R; Siddik Z H; Newman R A; Ohno S; Bull J M
Protective effect of ICRF-187 against normal tissue injury induced by adriamycin in combination with whole body hyperthermia.
Cancer research 1991;51(13):3568-77.
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1991: Ohno S; Siddik Z H; Baba H; Stephens L C; Strebel F R; Wondergem J; Khokhar A R; Bull J M
Effect of carboplatin combined with whole body hyperthermia on normal tissue and tumor in rats.
Cancer research 1991;51(11):2994-3000.
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1990: Khokhar A R; Xu Q Y; Siddik Z H
Synthesis, characterization, and antitumor activity of 1,2-bis(diphenylphosphino) ethane platinum(II) and palladium(II) complexes.
Journal of inorganic biochemistry 1990;39(2):117-23.
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1990: Newman R A; Siddik Z H; Travis E L; Followill D; Ayele W; Burditt T; Krakoff I H
Assessment of pulmonary and hematologic toxicities of liblomycin, a novel bleomycin analog.
Investigational new drugs 1990;8(1):33-41.
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1990: Graham R A; Siddik Z H; Hohn D C
Extracorporeal hemofiltration: a model for decreasing systemic drug exposure with intra-arterial chemotherapy.
Cancer chemotherapy and pharmacology 1990;26(3):210-4.
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1989: Baba H; Siddik Z H; Strebel F R; Jenkins G N; Bull J M
Increased therapeutic gain of combined cis-diamminedichloroplatinum (II) and whole body hyperthermia therapy by optimal heat/drug scheduling.
Cancer research 1989;49(24 Pt 1):7041-4.
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1989: Siddik Z H; Edwards M J; Boddie A W
Isolated limb perfusion with chemotherapeutic agents for melanoma: a reevaluation of drug dosimetry.
European journal of cancer & clinical oncology 1989;25(10):1393-7.
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1989: Wondergem J; Bulger R E; Siddik Z H; Leygraaf J W; Strebel F R; Alonso M; Travis E L; Bull J M
A comparison of thermal enhancement of cis-diamminedichloroplatinum (II) induced renal and intestinal toxicities by whole body hyperthermia in the rat.
International journal of radiation oncology, biology, physics 1989;16(6):1551-6.
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1989: Newman R A; Osborn S; Siddik Z H
Determination of tellurium in biological fluids by means of electrothermal vaporization-inductively coupled plasma-mass spectrometry (ETV-ICP-MS).
Clinica chimica acta; international journal of clinical chemistry 1989;179(2):191-6.
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1988: Wondergem J; Strebel F R; Siddik Z H; Newman R A; Bull J M
The effects of anaesthetics on cisplatinum-induced toxicity at normal temperatures and during whole-body hyperthermia: the influence of NaCl concentration of the vehicle.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1988;4(6):643-54.
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1988: Siddik Z H; Newman R A
Use of platinum as a modifier in the sensitive detection of tellurium in biological samples.
Analytical biochemistry 1988;172(1):190-6.
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1988: Bull J M; Strebel F R; Sunderland B A; Bulger R E; Edwards M; Siddik Z H; Newman R A
o-(beta-Hydroxyethyl)-rutoside-mediated protection of renal injury associated with cis-diamminedichloroplatinum(II)/hyperthermia treatment.
Cancer research 1988;48(8):2239-44.
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1988: Khokhar A R; Wright K; Siddik Z H; Perez-Soler R
Organ distribution and tumor uptake of liposome entrapped cis-bis-neodecanoato trans-R, R-1,2 diaminocyclohexane platinum (II) administered intravenously and into the proper hepatic artery.
Cancer chemotherapy and pharmacology 1988;22(3):223-7.
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