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Kenneth Siddle

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K B Boyle; Dirk Hadaschik; Sam Virtue; Will P Cawthorn; S H Ridley; Stephen O'Rahilly; Kenneth Siddle
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.
Kathy H Surinya; Briony E Forbes; Filomena Occhiodoro; Grant W Booker; Geoffrey L Francis; Kenneth Siddle; John C Wallace; Leah J Cosgrove
An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors.
Samira Benyoucef; Kathy H Surinya; Dirk Hadaschik; Kenneth Siddle
Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation.

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2009: K B Boyle; Dirk Hadaschik; Sam Virtue; Will P Cawthorn; S H Ridley; Stephen O'Rahilly; Kenneth Siddle
The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation.
Cell death and differentiation 2009;16(5):782-9.
2008: Kathy H Surinya; Briony E Forbes; Filomena Occhiodoro; Grant W Booker; Geoffrey L Francis; Kenneth Siddle; John C Wallace; Leah J Cosgrove
An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors.
The Journal of biological chemistry 2008;283(9):5355-63.
2007: Samira Benyoucef; Kathy H Surinya; Dirk Hadaschik; Kenneth Siddle
Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation.
The Biochemical journal 2007;403(3):603-13.
2006: Ranmali Nawaratne; Alexander Gray; Christina H Jørgensen; C Peter Downes; Kenneth Siddle; Jaswinder Sethi
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1838-52.
2006: Simon Parry; Dirk Hadaschik; Christine Blancher; Mande K Kumaran; Natalia Bochkina; Howard R Morris; Sylvia Richardson; Timothy J Aitman; Dominique Gauguier; Kenneth Siddle; James Scott; Anne Dell
Glycomics investigation into insulin action.
Biochimica et biophysica acta 2006;1760(4):652-68.
2006: Irini Rakatzi; Magdalene Stosik; Tanja Gromke; Kenneth Siddle; Jürgen Eckel
Differential phosphorylation of IRS-1 and IRS-2 by insulin and IGF-I receptors.
Archives of physiology and biochemistry 2006;112(1):37-47.
2005: Lowenna J Holt; Kenneth Siddle
Grb10 and Grb14: enigmatic regulators of insulin action--and more?
The Biochemical journal 2005;388(Pt 2):393-406.
2003: Giles S H Yeo; Kenneth Siddle
Attractin' more attention - new pieces in the obesity puzzle?
The Biochemical journal 2003;376(Pt 3):e7-8.
2003: Yumiko Okubo; Kenneth Siddle; Helen V Firth; Steve O'Rahilly; Louise C Wilson; Lionel Willatt; Toshiaki Fukushima; Shin-ichiro Takahashi; Clive J Petry; Tero Saukkonen; Richard Stanhope; David D Dunger
Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene.
The Journal of clinical endocrinology and metabolism 2003;88(12):5981-8.
2003: S George; A Johansen; Maria A Soos; Henrik B Mortensen; S Gammeltoft; Vladimir Saudek; Kenneth Siddle; L Hansen; Stephen O'Rahilly
Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject.
Endocrinology 2003;144(2):631-7.
2002: Claire Mulligan; Justin J Rochford; Gareth Denyer; Richard Stephens; Giles Yeo; Thomas Freeman; Kenneth Siddle; Stephen O'Rahilly
Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1.
The Journal of biological chemistry 2002;277(45):42480-7.
2002: Kathy H Surinya; Laurence Molina; Maria A Soos; Jakob Brandt; Claus Kristensen; Kenneth Siddle
Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies.
The Journal of biological chemistry 2002;277(19):16718-25.
2001: Kenneth Siddle; Birgitte Uraø; C A Niesler; D L Cope; Laurence Molina; Kathy H Surinya; Maria A Soos
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors.
Biochemical Society transactions 2001;29(Pt 4):513-25.
2001: CU Niesler; Johannes B Prins; Stephen O'Rahilly; Kenneth Siddle; Montague Carl
Adipose depot-specific expression of cIAP2 in human preadipocytes and modulation of expression by serum factors and TNFalpha.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(7):1027-33.
2001: V A Patel; Q J Zhang; Kenneth Siddle; Maria A Soos; M Goddard; Peter L Weissberg; Martin R Bennett
Defect in insulin-like growth factor-1 survival mechanism in atherosclerotic plaque-derived vascular smooth muscle cells is mediated by reduced surface binding and signaling.
Circulation research 2001;88(9):895-902.
2001: Birgitte Uraø; CU Niesler; Stephen O'Rahilly; Kenneth Siddle
Comparison of anti-apoptotic signalling by the insulin receptor and IGF-I receptor in preadipocytes and adipocytes.
Cellular signalling 2001;13(4):279-85.
2000: CU Niesler; Birgitte Uraø; Johannes B Prins; Kenneth Siddle
IGF-I inhibits apoptosis induced by serum withdrawal, but potentiates TNF-alpha-induced apoptosis, in 3T3-L1 preadipocytes.
The Journal of endocrinology 2000;167(1):165-74.
2000: Anna Bevan; P J Seabright; J Tikerpae; Barry Posner; GD Smith; Kenneth Siddle
The role of insulin dissociation from its endosomal receptor in insulin degradation.
Molecular and cellular endocrinology 2000;164(1-2):145-57.
2000: Laurence Molina; C Marino-Buslje; D R Quinn; Kenneth Siddle
Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding.
FEBS letters 2000;467(2-3):226-30.
1999: Birgitte Uraø; R A Brown; Stephen O'Rahilly; P R Shepherd; Kenneth Siddle
The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs.
FEBS letters 1999;460(3):423-6.
1999: Birgitte Uraø; D L Cope; H E Kalloo-Hosein; AC Hayward; Jonathan P Whitehead; Stephen O'Rahilly; Kenneth Siddle
Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes.
The Journal of biological chemistry 1999;274(43):30864-73.
1999: C Marino-Buslje; M Martin-Martinez; Kenji Mizuguchi; Kenneth Siddle; Tom L Blundell
The insulin receptor: from protein sequence to structure.
Biochemical Society transactions 1999;27(4):715-26.
1999: Giuseppe Pandini; Riccardo Vigneri; Angela Costantino; Francesco Frasca; Antonio M Ippolito; Yoko Fujita-Yamaguchi; Kenneth Siddle; Ira D Goldfine; Antonino Belfiore
Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1935-44.
1998: C Marino-Buslje; Kenji Mizuguchi; Kenneth Siddle; Tom L Blundell
A third fibronectin type III domain in the extracellular region of the insulin receptor family.
FEBS letters 1998;441(2):331-6.
1998: CU Niesler; Kenneth Siddle; Johannes B Prins
Human preadipocytes display a depot-specific susceptibility to apoptosis.
Diabetes 1998;47(8):1365-8.
1998: Peter R Shepherd; DJ Withers; Kenneth Siddle
Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling.
The Biochemical journal 1998;333 ( Pt 3)():471-90.
1998: Jonathan P Whitehead; PJ Humphreys; A Krook; R Jackson; A Hayward; H Lewis; Kenneth Siddle; Stephen O'Rahilly
Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: detection and functional analysis of a naturally occurring mutation in a YMXM motif.
Diabetes 1998;47(5):837-9.
1998: S Li; John Termini; A Hayward; Kenneth Siddle; Y Zick; AP Koval; Derek LeRoith; Yoko Fujita-Yamaguchi
The carboxyl-terminal domain of insulin-like growth factor-I receptor interacts with the insulin receptor and activates its protein tyrosine kinase.
FEBS letters 1998;421(1):45-9.
1997: Johannes B Prins; CU Niesler; Clay Winterford; Nicholas A Bright; Kenneth Siddle; Stephen O'Rahilly; NI Walker; DP Cameron
Tumor necrosis factor-alpha induces apoptosis of human adipose cells.
Diabetes 1997;46(12):1939-44.
1997: A Krook; Jonathan P Whitehead; S P Dobson; Matthew R Griffiths; M Ouwens; C Baker; AC Hayward; S K Sen; J A Maassen; Kenneth Siddle; Jeremy M Tavaré; Stephen O'Rahilly
Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects.
The Journal of biological chemistry 1997;272(48):30208-14.
1997: Anna Bevan; A Krook; J Tikerpae; P J Seabright; Kenneth Siddle; GD Smith
Chloroquine extends the lifetime of the activated insulin receptor complex in endosomes.
The Journal of biological chemistry 1997;272(43):26833-40.
1997: E M Bailyes; BT Navé; Maria A Soos; S R Orr; AC Hayward; Kenneth Siddle
Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.
The Biochemical journal 1997;327 ( Pt 1)():209-15.
1997: Peter R Shepherd; BT Nave; J Rincon; R J Haigh; E Foulstone; C Proud; Juleen R Zierath; Kenneth Siddle; Harriet Wallberg-Henriksson
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism.
Diabetologia 1997;40(10):1172-7.
1997: H E Kalloo-Hosein; Jonathan P Whitehead; Maria A Soos; Jeremy M Tavaré; Kenneth Siddle; Stephen O'Rahilly
Differential signaling to glycogen synthesis by the intracellular domain of the insulin versus the insulin-like growth factor-1 receptor. Evidence from studies of TrkC-chimeras.
The Journal of biological chemistry 1997;272(39):24325-32.
1997: Peter R Shepherd; Kenneth Siddle; BT Navé
Is stimulation of class-1 phosphatidylinositol 3-kinase activity by insulin sufficient to activate pathways involved in glucose metabolism.
Biochemical Society transactions 1997;25(3):978-81.
1997: Peter R Shepherd; BT Navé; J Rincon; LA Nolte; Anna Bevan; Kenneth Siddle; Juleen R Zierath; Harriet Wallberg-Henriksson
Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human skeletal muscle.
The Journal of biological chemistry 1997;272(30):19000-7.
1996: BT Navé; Kenneth Siddle; Peter R Shepherd
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport.
The Biochemical journal 1996;318 ( Pt 1)():203-5.
1996: BT Navé; R J Haigh; A C Hayward; Kenneth Siddle; Peter R Shepherd
Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes.
The Biochemical journal 1996;318 ( Pt 1)():55-60.
1996: A Krook; Maria A Soos; S Kumar; Kenneth Siddle; Stephen O'Rahilly
Functional activation of mutant human insulin receptor by monoclonal antibody.
Lancet 1996;347(9015):1586-90.
1995: Monika Kellerer; M Coghlan; Edison Capp; A Mühlhöfer; G Kroder; L Mosthaf; P Galante; Kenneth Siddle; Hans-Ulrich Häring
Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.
The Journal of clinical investigation 1995;96(1):6-11.
1995: Peter R Shepherd; Maria A Soos; Kenneth Siddle
Inhibitors of phosphoinositide 3-kinase block exocytosis but not endocytosis of transferrin receptors in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 1995;211(2):535-9.
1995: Peter R Shepherd; BT Navé; Kenneth Siddle
Insulin activates glycogen synthase by a novel PI 3-kinase/p70s6k dependent pathway in 3T3-L1 adipocytes.
Biochemical Society transactions 1995;23(2):202S.
1995: Peter R Shepherd; BT Navé; Kenneth Siddle
Involvement of PI 3-kinase in stimulation of glucose transport and recruitment of transferrin receptors in 3T3-L1 adipocytes.
Biochemical Society transactions 1995;23(2):201S.
1995: BT Navé; Peter R Shepherd; Kenneth Siddle
Effect of phorbol esters on phosphatidylinositol 3-kinase activity in adipocytes.
Biochemical Society transactions 1995;23(2):183S.
1995: R J Haigh; Peter R Shepherd; BT Navé; Kenneth Siddle
The role of phosphatidylinositol 3-kinase activity in insulin-stimulated mitogenesis in 3T3-L1 adipocytes.
Biochemical Society transactions 1995;23(2):179S.
1995: L Mosthaf; L Berti; Monika Kellerer; Joanne Mushack; E Seffer; B Bossenmaier; M Coghlan; Kenneth Siddle; A Ullrich; Hans-Ulrich Häring
C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity.
European journal of biochemistry / FEBS 1995;227(3):787-91.
1995: Peter R Shepherd; BT Navé; Kenneth Siddle
Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase.
The Biochemical journal 1995;305 ( Pt 1)():25-8.
1994: Matthew P Coghlan; T S Pillay; Jeremy M Tavaré; Kenneth Siddle
Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation.
The Biochemical journal 1994;303 ( Pt 3)():893-9.
1994: Kenneth Siddle; Maria A Soos; C E Field; BT Navé
Hybrid and atypical insulin/insulin-like growth factor I receptors.
Hormone research 1994;41 Suppl 2():56-64; discussion 65.
1993: Matthew P Coghlan; Kenneth Siddle
Phorbol esters induce insulin receptor phosphorylation in transfected fibroblasts without affecting tyrosine kinase activity.
Biochemical and biophysical research communications 1993;193(1):371-7.
1993: Maria A Soos; C E Field; Kenneth Siddle
Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.
The Biochemical journal 1993;290 ( Pt 2)():419-26.
1993: Maria A Soos; BT Navé; Kenneth Siddle
Immunological studies of type I IGF receptors and insulin receptors: characterisation of hybrid and atypical receptor subtypes.
Advances in experimental medicine and biology 1993;343():145-57.
1992: R H Ganderton; K K Stanley; C E Field; Matthew P Coghlan; Maria A Soos; Kenneth Siddle
A monoclonal anti-peptide antibody reacting with the insulin receptor beta-subunit. Characterization of the antibody and its epitope and use in immunoaffinity purification of intact receptors.
The Biochemical journal 1992;288 ( Pt 1)():195-205.
1992: Maria A Soos; C E Field; R Lammers; A Ullrich; B Zhang; R A Roth; Asser Sloth Andersen; Thomas Kjeldsen; Kenneth Siddle
A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity.
The Journal of biological chemistry 1992;267(18):12955-63.
1992: Kenneth Siddle
The insulin receptor and type I IGF receptor: comparison of structure and function.
Progress in growth factor research 1992;4(4):301-20.
1991: T S Pillay; Kenneth Siddle
Insulin-stimulated serine/threonine phosphorylation of the insulin receptor: paucity of threonine 1348 phosphorylation in vitro indicates the involvement of more than one serine/threonine kinase in vivo.
Biochemical and biophysical research communications 1991;179(2):962-71.
1991: T S Pillay; J Whittaker; R Lammers; A Ullrich; Kenneth Siddle
Multisite serine phosphorylation of the insulin and IGF-I receptors in transfected cells.
FEBS letters 1991;288(1-2):206-11.
1990: Maria A Soos; J Whittaker; R Lammers; A Ullrich; Kenneth Siddle
Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells.
The Biochemical journal 1990;270(2):383-90.
1990: N P Brindle; J M Tavare; M Dickens; J Whittaker; Kenneth Siddle
Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA.
The Biochemical journal 1990;268(3):615-20.
1990: S A Prigent; K K Stanley; Kenneth Siddle
Identification of epitopes on the human insulin receptor reacting with rabbit polyclonal antisera and mouse monoclonal antibodies.
The Journal of biological chemistry 1990;265(17):9970-7.
1990: T S Pillay; J Whittaker; Kenneth Siddle
Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: evidence for a major constitutive role in insulin receptor regulation.
Biochemical Society transactions 1990;18(3):494-5.
1990: J Whittaker; Maria A Soos; Kenneth Siddle
Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance.
Diabetes care 1990;13(6):576-81.
1989: Maria A Soos; Kenneth Siddle
Immunological relationships between receptors for insulin and insulin-like growth factor I. Evidence for structural heterogeneity of insulin-like growth factor I receptors involving hybrids with insulin receptors.
The Biochemical journal 1989;263(2):553-63.
1989: Maria A Soos; R M O'Brien; N P Brindle; J M Stigter; A K Okamoto; J Whittaker; Kenneth Siddle
Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(14):5217-21.
1989: W J Sobey; S F Beer; C A Carrington; P M Clark; Bruce Frank; I P Gray; S D Luzio; D R Owens; A E Schneider; Kenneth Siddle
Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins.
The Biochemical journal 1989;260(2):535-41.
1989: R O'Brien; Miles D Houslay; N P Brindle; G Milligan; J Whittaker; Kenneth Siddle
Binding to GDP-agarose identifies a novel 60kDa substrate for the insulin receptor tyrosyl kinase in mouse NIH-3T3 cells expressing high concentrations of the human insulin receptor.
Biochemical and biophysical research communications 1989;158(3):743-8.
1989: John C Hutton; P C Guest; C J Rhodes; Lloyd D Fricker; K A Grimaldi; Kenneth Siddle; W Davidson; E M Bailyes
[Biogenesis of the insulin secretion granule].
Journées annuelles de diabétologie de l'Hôtel-Dieu 1989;():13-28.
1988: R N Seabrook; E M Bailyes; Chris Price; Kenneth Siddle; J Paul Luzio
The distinction of bone and liver isoenzymes of alkaline phosphatase in serum using a monoclonal antibody.
Clinica chimica acta; international journal of clinical chemistry 1988;172(2-3):261-6.
1987: R M O'Brien; Maria A Soos; Kenneth Siddle
Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules.
The EMBO journal 1987;6(13):4003-10.
1987: K A Grimaldi; Kenneth Siddle; John C Hutton
Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.
The Biochemical journal 1987;245(2):567-73.
1987: K A Grimaldi; John C Hutton; Kenneth Siddle
Production and characterization of monoclonal antibodies to insulin secretory granule membranes.
The Biochemical journal 1987;245(2):557-66.
1987: E M Bailyes; R N Seabrook; J Calvin; G A Maguire; Chris Price; Kenneth Siddle; J Paul Luzio
The preparation of monoclonal antibodies to human bone and liver alkaline phosphatase and their use in immunoaffinity purification and in studying these enzymes when present in serum.
The Biochemical journal 1987;244(3):725-33.
1987: I P Gray; Kenneth Siddle; Bruce Frank; C N Hales
Characterization and use in immunoradiometric assay of monoclonal antibodies directed against human proinsulin.
Diabetes 1987;36(6):684-8.
1987: Kenneth Siddle; Maria A Soos; R M O'Brien; R H Ganderton; R Taylor
Monoclonal antibodies as probes of the structure and function of insulin receptors.
Biochemical Society transactions 1987;15(1):47-51.
1986: John C Hutton; Mina Peshavaria; H W Daivdson; K Grimaldi; R P Von Strandmann; Kenneth Siddle
The insulin secretory granule: features and functions in common with other endocrine granules.
Advances in experimental medicine and biology 1986;211():385-96.
1984: E M Bailyes; Maria A Soos; P Jackson; A C Newby; Kenneth Siddle; J P Luzio
The existence and properties of two dimers of rat liver ecto-5'-nucleotidase.
The Biochemical journal 1984;221(2):369-77.
1984: I P Gray; Kenneth Siddle; K Docherty; Bruce Frank; C N Hales
Proinsulin in human serum: problems in measurement and interpretation.
Clinical endocrinology 1984;21(1):43-7.