David Siderovski

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Kimple Adam J; Soundararajan Meera; Hutsell Stephanie Q; Roos Annette K; Urban Daniel J; Setola Vincent; Temple Brenda R S; Roth Bryan L; Knapp Stefan; Willard Francis S; Siderovski David P
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Preininger Anita M; Funk Michael A; Oldham William M; Meier Scott M; Johnston Christopher A; Adhikary Suraj; Kimple Adam J; Siderovski David P; Hamm Heidi E; Iverson Tina M
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Takimoto Eiki; Koitabashi Norimichi; Hsu Steven; Ketner Elizabeth A; Zhang Manling; Nagayama Takahiro; Bedja Djahida; Gabrielson Kathleen L; Blanton Robert; Siderovski David P; Mendelsohn Michael E; Kass David A
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.

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All Publications

2009: Kimple Adam J; Soundararajan Meera; Hutsell Stephanie Q; Roos Annette K; Urban Daniel J; Setola Vincent; Temple Brenda R S; Roth Bryan L; Knapp Stefan; Willard Francis S; Siderovski David P
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
The Journal of biological chemistry 2009;284(29):19402-11.
2009: Preininger Anita M; Funk Michael A; Oldham William M; Meier Scott M; Johnston Christopher A; Adhikary Suraj; Kimple Adam J; Siderovski David P; Hamm Heidi E; Iverson Tina M
Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry 2009;48(12):2630-42.
2009: Takimoto Eiki; Koitabashi Norimichi; Hsu Steven; Ketner Elizabeth A; Zhang Manling; Nagayama Takahiro; Bedja Djahida; Gabrielson Kathleen L; Blanton Robert; Siderovski David P; Mendelsohn Michael E; Kass David A
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
The Journal of clinical investigation 2009;119(2):408-20.
2009: Willard Francis S; Willard Melinda D; Kimple Adam J; Soundararajan Meera; Oestreich Emily A; Li Xiaoyan; Sowa Nathaniel A; Kimple Randall J; Doyle Declan A; Der Channing J; Zylka Mark J; Snider William D; Siderovski David P
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
PloS one 2009;4(3):e4884.
2008: Johnston Christopher A; Willard Melinda D; Kimple Adam J; Siderovski David P; Willard Francis S
A sweet cycle for Arabidopsis G-proteins: Recent discoveries and controversies in plant G-protein signal transduction.
Plant signaling & behavior 2008;3(12):1067-76.
2008: Willard Francis S; Zheng Zhen; Guo Juan; Digby Gregory J; Kimple Adam J; Conley Jason M; Johnston Christopher A; Bosch Dustin; Willard Melinda D; Watts Val J; Lambert Nevin A; Ikeda Stephen R; Du Quansheng; Siderovski David P
A point mutation to Galphai selectively blocks GoLoco motif binding: direct evidence for Galpha.GoLoco complexes in mitotic spindle dynamics.
The Journal of biological chemistry 2008;283(52):36698-710.
2008: Johnston Christopher A; Afshar Katayoun; Snyder Jason T; Tall Gregory G; Gönczy Pierre; Siderovski David P; Willard Francis S
Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans.
The Journal of biological chemistry 2008;283(31):21550-8.
2008: Johnston Christopher A; Kimple Adam J; Giguère Patrick M; Siderovski David P
Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2.
Structure (London, England : 1993) 2008;16(7):1086-94.
2008: Kimple Adam J; Yasgar Adam; Hughes Mark; Jadhav Ajit; Willard Francis S; Muller Robin E; Austin Christopher P; Inglese James; Ibeanu Gordon C; Siderovski David P; Simeonov Anton
A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.
Combinatorial chemistry & high throughput screening 2008;11(5):396-409.
2008: Willard Francis S; Siderovski David P
GPCR high throughput screening (part 1).
Combinatorial chemistry & high throughput screening 2008;11(5):336.
2008: Soundararajan Meera; Willard Francis S; Kimple Adam J; Turnbull Andrew P; Ball Linda J; Schoch Guillaume A; Gileadi Carina; Fedorov Oleg Y; Dowler Elizabeth F; Higman Victoria A; Hutsell Stephanie Q; Sundström Michael; Doyle Declan A; Siderovski David P
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(17):6457-62.
2008: Cheever Matthew L; Snyder Jason T; Gershburg Svetlana; Siderovski David P; Harden T Kendall; Sondek John
Crystal structure of the multifunctional Gbeta5-RGS9 complex.
Nature structural & molecular biology 2008;15(2):155-62.
2007: Johnston Christopher A; Temple Brenda R; Chen Jin-Gui; Gao Yajun; Moriyama Etsuko N; Jones Alan M; Siderovski David P; Willard Francis S
Comment on "A G protein coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid".
Science (New York, N.Y.) 2007;318(5852):914; author reply 914.
2007: Johnston Christopher A; Taylor J Philip; Gao Yajun; Kimple Adam J; Grigston Jeffrey C; Chen Jin-Gui; Siderovski David P; Jones Alan M; Willard Francis S
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17317-22.
2007: Kimple Adam J; Willard Francis S; Giguère Patrick M; Johnston Christopher A; Mocanu Viorel; Siderovski David P
The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face.
Biochimica et biophysica acta 2007;1774(9):1213-20.
2007: Sammond Deanne W; Eletr Ziad M; Purbeck Carrie; Kimple Randall J; Siderovski David P; Kuhlman Brian
Structure-based protocol for identifying mutations that enhance protein-protein binding affinities.
Journal of molecular biology 2007;371(5):1392-404.
2007: Johnston Christopher A; Siderovski David P
Receptor-mediated activation of heterotrimeric G-proteins: current structural insights.
Molecular pharmacology 2007;72(2):219-30.
2007: Willard Melinda D; Willard Francis S; Li Xiaoyan; Cappell Steven D; Snider William D; Siderovski David P
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
The EMBO journal 2007;26(8):2029-40.
2007: Johnston Christopher A; Siderovski David P
Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(6):2001-6.
2007: Liu Hao; Suresh Angayarkanni; Willard Francis S; Siderovski David P; Lu Shen; Naqvi Naweed I
Rgs1 regulates multiple Galpha subunits in Magnaporthe pathogenesis, asexual growth and thigmotropism.
The EMBO journal 2007;26(3):690-700.
2007: Willard Francis S; Low Aaron B; McCudden Christopher R; Siderovski David P
Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins.
Cellular signalling 2007;19(2):428-38.
2006: Johnston Christopher A; Lobanova Ekaterina S; Shavkunov Alexander S; Low Justin; Ramer J Kevin; Blaesius Rainer; Fredericks Zoey; Willard Francis S; Kuhlman Brian; Arshavsky Vadim Y; Siderovski David P
Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.
Biochemistry 2006;45(38):11390-400.
2006: Dho Sascha E; Trejo JoAnn; Siderovski David P; McGlade C Jane
Dynamic regulation of mammalian numb by G protein-coupled receptors and protein kinase C activation: Structural determinants of numb association with the cortical membrane.
Molecular biology of the cell 2006;17(9):4142-55.
2006: Fatemi S Hossein; Reutiman Teri J; Folsom Timothy D; Bell Christopher; Nos Lisa; Fried Peter; Pearce David A; Singh Sushmita; Siderovski David P; Willard Francis S; Fukuda Mitsunori
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(9):1888-99.
2006: Willard Francis S; McCudden Christopher R; Siderovski David P
G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).
Cellular signalling 2006;18(8):1226-34.
2006: Sambi Balwinder S; Hains Melinda D; Waters Catherine M; Connell Michelle C; Willard Francis S; Kimple Adam J; Pyne Susan; Siderovski David P; Pyne Nigel J
The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells.
Cellular signalling 2006;18(7):971-81.
2006: Willard Francis S; Siderovski David P
Covalent immobilization of histidine-tagged proteins for surface plasmon resonance.
Analytical biochemistry 2006;353(1):147-9.
2006: Hains Melinda D; Wing Michele R; Maddileti Savitri; Siderovski David P; Harden T Kendall
Galpha12/13- and rho-dependent activation of phospholipase C-epsilon by lysophosphatidic acid and thrombin receptors.
Molecular pharmacology 2006;69(6):2068-75.
2006: Paing May M; Johnston Christopher A; Siderovski David P; Trejo Joann
Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization.
Molecular and cellular biology 2006;26(8):3231-42.
2006: Chasse Scott A; Flanary Paul; Parnell Stephen C; Hao Nan; Cha Jiyoung Y; Siderovski David P; Dohlman Henrik G
Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
Eukaryotic cell 2006;5(2):330-46.
2006: Willard Francis S; Siderovski David P
The R6A-1 peptide binds to switch II of Galphai1 but is not a GDP-dissociation inhibitor.
Biochemical and biophysical research communications 2006;339(4):1107-12.
2005: Zigman Mihaela; Cayouette Michel; Charalambous Christoforos; Schleiffer Alexander; Hoeller Oliver; Dunican Dara; McCudden Christopher R; Firnberg Nicole; Barres Ben A; Siderovski David P; Knoblich Juergen A
Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina.
Neuron 2005;48(4):539-45.
2005: Wang Hongyan; Ng Kian Hong; Qian Hongliang; Siderovski David P; Chia William; Yu Fengwei
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.
Nature cell biology 2005;7(11):1091-8.
2005: Johnston Christopher A; Ramer J Kevin; Blaesius Rainer; Fredericks Zoey; Watts Val J; Siderovski David P
A bifunctional Galphai/Galphas modulatory peptide that attenuates adenylyl cyclase activity.
FEBS letters 2005;579(25):5746-50.
2005: Afshar Katayoun; Willard Francis S; Colombo Kelly; Siderovski David P; Gönczy Pierre
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
Development (Cambridge, England) 2005;132(20):4449-59.
2005: Martin-McCaffrey Luke; Hains Melinda D; Pritchard Grant A; Pajak Agnieszka; Dagnino Lina; Siderovski David P; D'Souza Sudhir J A
Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 2005;234(2):438-44.
2005: McCudden Christopher R; Willard Francis S; Kimple Randall J; Johnston Christopher A; Hains Melinda D; Jones Miller B; Siderovski David P
G alpha selectivity and inhibitor function of the multiple GoLoco motif protein GPSM2/LGN.
Biochimica et biophysica acta 2005;1745(2):254-64.
2005: Johnston Christopher A; Willard Francis S; Jezyk Mark R; Fredericks Zoey; Bodor Erik T; Jones Miller B; Blaesius Rainer; Watts Val J; Harden T Kendall; Sondek John; Ramer J Kevin; Siderovski David P
Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchange.
Structure (London, England : 1993) 2005;13(7):1069-80.
2005: Martin-McCaffrey Luke; Willard Francis S; Pajak Agnieszka; Dagnino Lina; Siderovski David P; D'Souza Sudhir J A
RGS14 is a microtubule-associated protein.
Cell cycle (Georgetown, Tex.) 2005;4(7):953-60.
2005: Willard Francis S; Kimple Adam J; Johnston Christopher A; Siderovski David P
A direct fluorescence-based assay for RGS domain GTPase accelerating activity.
Analytical biochemistry 2005;340(2):341-51.
2005: Webb Christina K; McCudden Christopher R; Willard Francis S; Kimple Randall J; Siderovski David P; Oxford Gerry S
D2 dopamine receptor activation of potassium channels is selectively decoupled by Galpha-specific GoLoco motif peptides.
Journal of neurochemistry 2005;92(6):1408-18.
2005: McCudden C R; Hains M D; Kimple R J; Siderovski D P; Willard F S
G-protein signaling: back to the future.
Cellular and molecular life sciences : CMLS 2005;62(5):551-77.
2005: Uhlik Mark T; Temple Brenda; Bencharit Sompop; Kimple Adam J; Siderovski David P; Johnson Gary L
Structural and evolutionary division of phosphotyrosine binding (PTB) domains.
Journal of molecular biology 2005;345(1):1-20.
2005: Richman Ryan W; Strock Jesse; Hains Melinda D; Cabanilla Nory Jun; Lau King-Kei; Siderovski David P; Diversé-Pierluissi María
RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel.
The Journal of biological chemistry 2005;280(2):1521-8.
2005: Siderovski David P; Willard Francis S
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits.
International journal of biological sciences 2005;1(2):51-66.
2004: Martin-McCaffrey Luke; Willard Francis S; Oliveira-dos-Santos Antonio J; Natale David R C; Snow Bryan E; Kimple Randall J; Pajak Agnieszka; Watson Andrew J; Dagnino Lina; Penninger Josef M; Siderovski David P; D'Souza Sudhir J A
RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote.
Developmental cell 2004;7(5):763-9.
2004: Afshar Katayoun; Willard Francis S; Colombo Kelly; Johnston Christopher A; McCudden Christopher R; Siderovski David P; Gönczy Pierre
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
Cell 2004;119(2):219-30.
2004: Jones Miller B; Siderovski David P; Hooks Shelley B
The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention.
Molecular interventions 2004;4(4):200-14.
2004: Kimple Randall J; Willard Francis S; Hains Melinda D; Jones Miller B; Nweke Gift K; Siderovski David P
Guanine nucleotide dissociation inhibitor activity of the triple GoLoco motif protein G18: alanine-to-aspartate mutation restores function to an inactive second GoLoco motif.
The Biochemical journal 2004;378(Pt 3):801-8.
2004: Kimple Randall J; Willard Francis S; Siderovski David P
Purification and in vitro functional analyses of RGS12 and RGS14 GoLoco motif peptides.
Methods in enzymology 2004;390():416-36.
2004: Martin-McCaffrey Luke; Willard Francis S; Pajak Agnieszka; Dagnino Lina; Siderovski David P; D'Souza Sudhir J A
Analysis of interactions between regulator of G-protein signaling-14 and microtubules.
Methods in enzymology 2004;390():240-58.
2004: Willard Francis S; Siderovski David P
Purification and in vitro functional analysis of the Arabidopsis thaliana regulator of G-protein signaling-1.
Methods in enzymology 2004;389():320-38.
2004: Hains Melinda D; Siderovski David P; Harden T Kendall
Application of RGS box proteins to evaluate G-protein selectivity in receptor-promoted signaling.
Methods in enzymology 2004;389():71-88.
2004: Willard Francis S; Kimple Randall J; Kimple Adam J; Johnston Christopher A; Siderovski David P
Fluorescence-based assays for RGS box function.
Methods in enzymology 2004;389():56-71.
2004: Willard Francis S; Kimple Randall J; Siderovski David P
Return of the GDI: the GoLoco motif in cell division.
Annual review of biochemistry 2004;73():925-51.
2003: Tang K Mary; Wang Guang-rong; Lu Ping; Karas Richard H; Aronovitz Mark; Heximer Scott P; Kaltenbronn Kevin M; Blumer Kendall J; Siderovski David P; Zhu Yan; Mendelsohn Michael E;
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Nature medicine 2003;9(12):1506-12.
2003: Chen Jin-Gui; Willard Francis S; Huang Jirong; Liang Jiansheng; Chasse Scott A; Jones Alan M; Siderovski David P
A seven-transmembrane RGS protein that modulates plant cell proliferation.
Science (New York, N.Y.) 2003;301(5640):1728-31.
2003: Rojas Rafael J; Kimple Randall J; Rossman Kent L; Siderovski David P; Sondek John
Established and emerging fluorescence-based assays for G-protein function: Ras-superfamily GTPases.
Combinatorial chemistry & high throughput screening 2003;6(4):409-18.
2003: Kimple Randall J; Jones Miller B; Shutes Adam; Yerxa Benjamin R; Siderovski David P; Willard Francis S
Established and emerging fluorescence-based assays for G-protein function: heterotrimeric G-protein alpha subunits and regulator of G-protein signaling (RGS) proteins.
Combinatorial chemistry & high throughput screening 2003;6(4):399-407.
2003: Colombo Kelly; Grill Stephan W; Kimple Randall J; Willard Francis S; Siderovski David P; Gönczy Pierre
Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Science (New York, N.Y.) 2003;300(5627):1957-61.
2003: Pruitt Wendy M; Karnoub Antoine E; Rakauskas A Corinne; Guipponi Michel; Antonarakis Stylianos E; Kurakin Alexei; Kay Brian K; Sondek John; Siderovski David P; Der Channing J
Role of the pleckstrin homology domain in intersectin-L Dbl homology domain activation of Cdc42 and signaling.
Biochimica et biophysica acta 2003;1640(1):61-8.
2002: Lambert John M; Lambert Que T; Reuther Gary W; Malliri Angeliki; Siderovski David P; Sondek John; Collard John G; Der Channing J
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
Nature cell biology 2002;4(8):621-5.
2002: Wang Qin; Liu Min; Mullah Bashar; Siderovski David P; Neubig Richard R
Receptor-selective effects of endogenous RGS3 and RGS5 to regulate mitogen-activated protein kinase activation in rat vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(28):24949-58.
2002: Booden Michelle A; Siderovski David P; Der Channing J
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.
Molecular and cellular biology 2002;22(12):4053-61.
2002: Snyder Jason T; Worthylake David K; Rossman Kent L; Betts Laurie; Pruitt Wendy M; Siderovski David P; Der Channing J; Sondek John
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Nature structural biology 2002;9(6):468-75.
2002: Kimple Randall J; Willard Francis S; Siderovski David P
The GoLoco motif: heralding a new tango between G protein signaling and cell division.
Molecular interventions 2002;2(2):88-100.
2002: Kimple Randall J; Kimple Michelle E; Betts Laurie; Sondek John; Siderovski David P
Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits.
Nature 2002;416(6883):878-81.
2002: Neubig Richard R; Siderovski David P
Regulators of G-protein signalling as new central nervous system drug targets.
Nature reviews. Drug discovery 2002;1(3):187-97.
2002: Rossman Kent L; Worthylake David K; Snyder Jason T; Siderovski David P; Campbell Sharon L; Sondek John
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
The EMBO journal 2002;21(6):1315-26.
2002: Snow Bryan E; Brothers Greg M; Siderovski David P
Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain.
Methods in enzymology 2002;344():740-61.
2002: Siderovski David P; Snow Bryan E; Chung Stephen; Brothers Greg M; Sondek John; Betts Laurie
Assays of complex formation between RGS protein G gamma subunit-like domains and G beta subunits.
Methods in enzymology 2002;344():702-23.
2001: Blake B L; Wing M R; Zhou J Y; Lei Q; Hillmann J R; Behe C I; Morris R A; Harden T K; Bayliss D A; Miller R J; Siderovski D P
G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).
The Journal of biological chemistry 2001;276(52):49267-74.
2001: Wing M R; Houston D; Kelley G G; Der C J; Siderovski D P; Harden T K
Activation of phospholipase C-epsilon by heterotrimeric G protein betagamma-subunits.
The Journal of biological chemistry 2001;276(51):48257-61.
2001: Snyder J T; Rossman K L; Baumeister M A; Pruitt W M; Siderovski D P; Der C J; Lemmon M A; Sondek J
Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins.
The Journal of biological chemistry 2001;276(49):45868-75.
2001: Kimple M E; Siderovski D P; Sondek J
Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.
The EMBO journal 2001;20(16):4414-22.
2001: Kimple R J; De Vries L; Tronchère H; Behe C I; Morris R A; Gist Farquhar M; Siderovski D P
RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.
The Journal of biological chemistry 2001;276(31):29275-81.
2001: Sondek J; Siderovski D P
Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.
Biochemical pharmacology 2001;61(11):1329-37.
2000: Schiff M L; Siderovski D P; Jordan J D; Brothers G; Snow B; De Vries L; Ortiz D F; Diversé-Pierluissi M
Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.
Nature 2000;408(6813):723-7.
2000: De Vries L; Fischer T; Tronchère H; Brothers G M; Strockbine B; Siderovski D P; Farquhar M G
Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14364-9.
2000: Liu Y; Snow B E; Hande M P; Yeung D; Erdmann N J; Wakeham A; Itie A; Siderovski D P; Lansdorp P M; Robinson M O; Harrington L
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo.
Current biology : CB 2000;10(22):1459-62.
2000: Liu Y; Snow B E; Hande M P; Baerlocher G; Kickhoefer V A; Yeung D; Wakeham A; Itie A; Siderovski D P; Lansdorp P M; Robinson M O; Harrington L
Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.
Molecular and cellular biology 2000;20(21):8178-84.
2000: Oliveira-Dos-Santos A J; Matsumoto G; Snow B E; Bai D; Houston F P; Whishaw I Q; Mariathasan S; Sasaki T; Wakeham A; Ohashi P S; Roder J C; Barnes C A; Siderovski D P; Penninger J M
Regulation of T cell activation, anxiety, and male aggression by RGS2.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12272-7.
1999: Siderovski D P; Diversé-Pierluissi M a; De Vries L
The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factor.
Trends in biochemical sciences 1999;24(9):340-1.
1999: Snow B E; Betts L; Mangion J; Sondek J; Siderovski D P
Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6489-94.
1999: Susin S A; Lorenzo H K; Zamzami N; Marzo I; Snow B E; Brothers G M; Mangion J; Jacotot E; Costantini P; Loeffler M; Larochette N; Goodlett D R; Aebersold R; Siderovski D P; Penninger J M; Kroemer G
Molecular characterization of mitochondrial apoptosis-inducing factor.
Nature 1999;397(6718):441-6.
1999: Siderovski D P; Strockbine B; Behe C I
Whither goest the RGS proteins?
Critical reviews in biochemistry and molecular biology 1999;34(4):215-51.
1998: Snow B E; Krumins A M; Brothers G M; Lee S F; Wall M A; Chung S; Mangion J; Arya S; Gilman A G; Siderovski D P
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(22):13307-12.
1998: Stambolic V; Suzuki A; de la Pompa J L; Brothers G M; Mirtsos C; Sasaki T; Ruland J; Penninger J M; Siderovski D P; Mak T W
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Cell 1998;95(1):29-39.
1998: Snow B E; Hall R A; Krumins A M; Brothers G M; Bouchard D; Brothers C A; Chung S; Mangion J; Gilman A G; Lefkowitz R J; Siderovski D P
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
The Journal of biological chemistry 1998;273(28):17749-55.
1998: Yee A A; Yin P; Siderovski D P; Mak T W; Litchfield D W; Arrowsmith C H
Cooperative interaction between the DNA-binding domains of PU.1 and IRF4.
Journal of molecular biology 1998;279(5):1075-83.
1998: Snow B E; Antonio L; Suggs S; Siderovski D P
Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene.
Gene 1998;206(2):247-53.
1997: Snow B E; Antonio L; Suggs S; Gutstein H B; Siderovski D P
Molecular cloning and expression analysis of rat Rgs12 and Rgs14.
Biochemical and biophysical research communications 1997;233(3):770-7.
1996: Grossman A; Mittrücker H W; Nicholl J; Suzuki A; Chung S; Antonio L; Suggs S; Sutherland G R; Siderovski D P; Mak T W
Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25.
Genomics 1996;37(2):229-33.
1996: Wu H K; Heng H H; Siderovski D P; Dong W F; Okuno Y; Shi X M; Tsui L C; Minden M D
Identification of a human LIM-Hox gene, hLH-2, aberrantly expressed in chronic myelogenous leukaemia and located on 9q33-34.1.
Oncogene 1996;12(6):1205-12.
1996: Siderovski D P; Hessel A; Chung S; Mak T W; Tyers M
A new family of regulators of G-protein-coupled receptors?
Current biology : CB 1996;6(2):211-2.
1995: Wu H K; Heng H H; Shi X M; Forsdyke D R; Tsui L C; Mak T W; Minden M D; Siderovski D P
Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1995;9(8):1291-8.
1995: Matsuyama T; Grossman A; Mittrücker H W; Siderovski D P; Kiefer F; Kawakami T; Richardson C D; Taniguchi T; Yoshinaga S K; Mak T W
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).
Nucleic acids research 1995;23(12):2127-36.
1994: Siderovski D P; Heximer S P; Forsdyke D R
A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.
DNA and cell biology 1994;13(2):125-47.
1993: Siderovski D P; Mak T W
RAMHA: a PC-based Monte-Carlo simulation of random saturation mutagenesis.
Computers in biology and medicine 1993;23(6):463-74.
1992: Molina T J; Kishihara K; Siderovski D P; van Ewijk W; Narendran A; Timms E; Wakeham A; Paige C J; Hartmann K U; Veillette A
Profound block in thymocyte development in mice lacking p56lck.
Nature 1992;357(6374):161-4.
1990: Siderovski D P; Blum S; Forsdyke R E; Forsdyke D R
A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes.
DNA and cell biology 1990;9(8):579-87.

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