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John Sidney

Research Profile

Chemicals & Drugs

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Bianca R Mothé; A Michelle English; Ilka Hoof; Donald F Hunt; Jeffrey Shabanowitz; John Sidney; Scott Southwood; Amanda Wriston; Alessandro Sette
Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.
Denise M McKinney; Carla Oseroff; Bjoern Peters; Veronique Schulten; Thomas J Scriba; Rafeul Alam; Cecilia S Lindestam Arlehamn; David Broide; Willem A Hanekom; Denise Hinz; John Sidney; Scott Southwood; Randy Taplitz; Robert Wood; Alessandro Sette
A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population.
Boris Engels; David M Kranz; Rebecca B Liu; Stephen C Meredith; Donald A Rowley; David C Binder; Victor H Engelhard; Alessandro Sette; John Sidney; Hans Schreiber
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.

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2013: Bianca R Mothé; A Michelle English; Ilka Hoof; Donald F Hunt; Jeffrey Shabanowitz; John Sidney; Scott Southwood; Amanda Wriston; Alessandro Sette
Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles.
Immunogenetics 2013;65(5):371-86.
2013: Denise M McKinney; Carla Oseroff; Bjoern Peters; Veronique Schulten; Thomas J Scriba; Rafeul Alam; Cecilia S Lindestam Arlehamn; David Broide; Willem A Hanekom; Denise Hinz; John Sidney; Scott Southwood; Randy Taplitz; Robert Wood; Alessandro Sette
A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population.
Immunogenetics 2013;65(5):357-70.
2013: Boris Engels; David M Kranz; Rebecca B Liu; Stephen C Meredith; Donald A Rowley; David C Binder; Victor H Engelhard; Alessandro Sette; John Sidney; Hans Schreiber
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Cancer cell 2013;23(4):516-26.
2013: Véronique Schulten; Alessandro Sette; John Sidney; Fatima Ferreira; Rapheul Alam; David H Broide; Fatima Ferreira-Briza; Jason A Greenbaum; Howard M Grey; Michael Hauser; Ravi Kolla; Cecilia S Lindestam Arlehamn; Denise M McKinney; Carla Oseroff; Bjoern Peters
Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(9):3459-64.
2013: John Sidney; Scott Southwood; Howard M Grey; Carrie Moore; Carla Oseroff; Clemencia Pinilla; Alessandro Sette
Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2013;Chapter 18():Unit 18.3..
2013: Cecilia S Lindestam Arlehamn; Denise M McKinney; Federico Mele; Bjoern Peters; Federica Sallusto; Anna Gerasimova; Jason A Greenbaum; Howard Grey; Ryan Henderson; Eddie A James; Yohan Kim; William W Kwok; John Sidney; Justine Swann; Randy Taplitz; Alessandro Sette
Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.
PLoS pathogens 2013;9(1):e1003130.
2012: Ann Cai; David S DeLuca; Naa Norkor Hammond; Derin B Keskin; Valentina Nardi; Donna Neuberg; John Sidney; Richard M Stone; Anselmo Alonso; Vladimir Brusic; Guang Lan Zhang; Wandi Zhang; Catherine J Wu
Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(20):5761-72.
2012: Carla Oseroff; Bjoern Peters; Federica Sallusto; Rafeul Alam; Tess M Brodie; David H Broide; Jason A Greenbaum; Howard Grey; Ravi Kolla; Denise M McKinney; John Sidney; Scott Southwood; Victoria Tripple; Randi Vita; Alessandro Sette
T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(4):1800-11.
2012: Carla Oseroff; Bjoern Peters; Anna Pomés; David H Broide; Jason Greenbaum; Howard Grey; Ravi Kolla; John Sidney; Victoria Tripple; Robert A Wood; Alessandro Sette
Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(2):679-88.
2012: David A Ostrov; Soren Buus; Cesar Augusto F de Oliveira; A Michelle English; Barry J Grant; Howard M Grey; Mikkel Harndahl; Donald F Hunt; Jean Jakoncic; Shun Lu; Andrew Lucas; Simon Mallal; Hu Mei; Carla Oseroff; Elizabeth Phillips; Yuri A Pompeu; Alessandro Sette; Jeffrey Shabanowitz; Leming Shi; John Sidney; Scott Southwood; Amanda Wriston; Lun Yang; Bjoern Peters
Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9959-64.
2012: Alessandro Sette; John Sidney; Scott Southwood; David Watkins; Nancy A Wilson; Jessica Berry; Kate Bradley; Courtney Dow; William H Hildebrand; Ilka Hoof; Mark G Lewis; Curtis P McMurtrey; Carrie Moore; Bianca R Mothé
A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules.
Immunogenetics 2012;64(6):421-34.
2012: Carrie Moore; Bianca R Mothé; Kate Bradley; A Michelle English; Donald F Hunt; Bernard A P Lafont; Jeffrey Shabanowitz; John Sidney; Scott Southwood; Amanda Wriston; Alessandro Sette
Identification of the peptide-binding motif recognized by the pigtail macaque class I MHC molecule Mane-A1*082:01 (Mane A*0301).
Immunogenetics 2012;64(6):461-8.
2012: Kelly P Burke; Jordana Levine; Lin Liu; Supriya Munshaw; William O Osburn; Stuart C Ray; Alessandro Sette; John Sidney; Andrea L Cox
Immunogenicity and cross-reactivity of a representative ancestral sequence in hepatitis C virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):5177-88.
2012: Cecilia S Lindestam Arlehamn; John Sidney; Randy Taplitz; Rhea N Coler; Jason A Greenbaum; Howard Grey; Ryan Henderson; Eddie A James; William W Kwok; Denise M McKinney; Magdalini Moutaftsi; Daniel Park; Bjoern Peters; Alessandro Sette
Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ).
Journal of immunology (Baltimore, Md. : 1950) 2012;188(10):5020-31.
2012: Karin Schreiber; Alessandro Sette; John Sidney; Michael T Spiotto; Ralph R Weichselbaum; Ainhoa Arina; Boris Engels; Theodore G Karrison; Donald A Rowley; Hans Schreiber
Spleen cells from young but not old immunized mice eradicate large established cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(9):2526-33.
2011: Jason S Reed; RA Rudersdorf; Alessandro Sette; John Sidney; Andrew D Walsh; David Ian Watkins; Wilfried Bardet; Benjamin J Burwitz; Christopher M Eernisse; Jessica Furlott; Chrystal E Glidden; William H Hildebrand; Holly L Kolar; Enrique J León; Nicholas J Maness; Curtis P McMurtrey; David O'Connor; Shari M Piaskowski; Nancy A Wilson
The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection.
Immunogenetics 2011;63(12):789-807.
2011: Maya F Kotturi; William W Kwok; Bjoern Peters; Rafi Ahmed; Rama S Akondy; Cecilia Lindestam Arlehamn; Michael J Buchmeier; Eddie A James; Ravi V Kolla; John Sidney; Justine A Swann; Alessandro Sette
Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.
Journal of virology 2011;85(22):11770-80.
2011: David Friedrich; Warren L Dinges; Yunda Huang; Emilie Jalbert; M Juliana McElrath; Alex Sette; John Sidney; Helen Horton
Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1.
Journal of acquired immune deficiency syndromes (1999) 2011;58(3):248-52.
2011: Daniela Weiskopf; Lauren E Yauch; Sujan Shresta; John Sidney; Michael A Angelo; Aruna D De Silva; Aravinda M de Silva; Jason A Greenbaum; Howard Grey; Daisy V John; Ravi V Kolla; Bjoern Peters; Alessandro Sette
Insights into HLA-restricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(8):4268-79.
2011: Christoph Neumann-Haefelin; Katja Nitschke; Cesar Oniangue-Ndza; Karen A Power; Laura L Reyor; Julia Schmidt; Alessandro Sette; John Sidney; Robert Thimme; Marco Binder; Stéphane Bressanelli; Célia Caillet-Saguy; Matthew R Henn; Kelsey Hills-Evans; Susan Ingber; Michael W Kemper; Nadine Kersting; Arthur Y Kim; Thomas Kuntzen; Georg M Lauer; Volker Lohmann; Todd M Allen
Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations.
Hepatology (Baltimore, Md.) 2011;54(4):1157-66.
2011: Christoph T Berger; Jason M Brenchley; Daniel C Douek; Nicole Frahm; Musie Ghebremichael; Kari L Hartman; Leah M Henry; Daniel E Kaufmann; Beatriz Mothe; Florencia Pereyra; David A Price; Laura E Ruff; Alessandro Sette; John Sidney; Vanessa Venturi; Bruce D Walker; Christian Brander
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control.
Journal of virology 2011;85(18):9334-45.
2011: Jason Greenbaum; John Sidney; Jolan Chung; Christian Brander; Bjoern Peters; Alessandro Sette
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes.
Immunogenetics 2011;63(6):325-35.
2011: Scott Southwood; Christopher Solomon; Ilka Hoof; Richard Rudersdorf; John Sidney; Bjoern Peters; Angela Wahl; Oriana Hawkins; William Hildebrand; Bianca R Mothé; Alessandro Sette
Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificities.
Immunogenetics 2011;63(5):275-90.
2011: Hua Cong; Ernest J Mui; William H Witola; John Sidney; Jeff Alexander; Alessandro Sette; Ajesh Maewal; Rima McLeod
Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201.
Vaccine 2011;29(4):754-62.
2011: Peng Wang; Alessandro Sette; John Sidney; Bjoern Peters
A computational pipeline to generate MHC binding motifs.
Immunome research 2011;7(2):3.
2010: John Sidney; Amiyah Steen; Carrie Moore; Sandy Ngo; Jolan Chung; Bjoern Peters; Alessandro Sette
Divergent motifs but overlapping binding repertoires of six HLA-DQ molecules frequently expressed in the worldwide human population.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(7):4189-98.
2010: Jason Botten; J Lindsay Whitton; Polly Barrowman; John Sidney; Jason K Whitmire; Jeff Alexander; Maya F Kotturi; Alessandro Sette; Michael J Buchmeier
A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans.
Journal of virology 2010;84(19):9947-56.
2010: Carla Oseroff; John Sidney; Maya F Kotturi; Ravi Kolla; Rafeul Alam; David H Broide; Stephen I Wasserman; Daniela Weiskopf; Denise M McKinney; Jo L Chung; Arnd Petersen; Howard Grey; Bjoern Peters; Alessandro Sette
Molecular determinants of T cell epitope recognition to the common Timothy grass allergen.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(2):943-55.
2010: Christopher Solomon; Scott Southwood; Ilka Hoof; Richard Rudersdorf; Bjoern Peters; John Sidney; Clemencia Pinilla; Maria Cecilia Garibaldi Marcondes; Binhua Ling; Preston Marx; Alessandro Sette; Bianca R Mothé
The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype.
Immunogenetics 2010;62(7):451-64.
2010: Jason Botten; John Sidney; Bianca R Mothé; Bjoern Peters; Alessandro Sette; Maya F Kotturi
Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system.
Microbiology and molecular biology reviews : MMBR 2010;74(2):157-70.
2010: Tze Guan Tan; Ernest J Mui; Hua Cong; William H Witola; Alexandre Montpetit; Stephen P Muench; John Sidney; Jeff Alexander; Alessandro Sette; Michael E Grigg; Ajesh Maewal; Rima McLeod
Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.
Vaccine 2010;28(23):3977-89.
2010: Jeff Alexander; Pamuk Bilsel; Marie-France del Guercio; Aleksandra Marinkovic-Petrovic; Scott Southwood; Stephani Stewart; Glenn Ishioka; Maya F Kotturi; Jason Botten; John Sidney; Mark Newman; Alessandro Sette
Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus.
Human immunology 2010;71(5):468-74.
2010: John Sidney; Amiyah Steen; Carrie Moore; Sandy Ngo; Jolan Chung; Bjoern Peters; Alessandro Sette
Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(5):2492-503.
2010: Hua Cong; Ernest J Mui; William H Witola; John Sidney; Jeff Alexander; Alessandro Sette; Ajesh Maewal; Rima McLeod
Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii.
Immunome research 2010;6():12.
2010: Peng Wang; John Sidney; Yohan Kim; Alessandro Sette; Ole Lund; Morten Nielsen; Bjoern Peters
Peptide binding predictions for HLA DR, DP and DQ molecules.
BMC bioinformatics 2010;11():568.
2010: Jo L Chung; Jian Sun; John Sidney; Alessandro Sette; Bjoern Peters
IMMUNOCAT-a data management system for epitope mapping studies.
Journal of biomedicine & biotechnology 2010;2010():856842.
2010: Maya F Kotturi; Jason Botten; Matt Maybeno; John Sidney; Jean Glenn; Huynh-Hoa Bui; Carla Oseroff; Shane Crotty; Bjoern Peters; Howard Grey; Daniel M Altmann; Michael J Buchmeier; Alessandro Sette
Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage.
Immunome research 2010;6():4.
2009: Alessandro Sette; Howard Grey; Carla Oseroff; Bjoern Peters; Magdalini Moutaftsi; Shane Crotty; Erika Assarsson; Jay Greenbaum; Yohan Kim; Ravi Kolla; David Tscharke; David Koelle; R Paul Johnson; Janice Blum; Steven Head; John Sidney
Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens.
Vaccine 2009;27 Suppl 6():G21-6.
2009: Maya F Kotturi; Jason Botten; John Sidney; Huynh-Hoa Bui; Lori Giancola; Matt Maybeno; Josie Babin; Carla Oseroff; Valerie Pasquetto; Jason A Greenbaum; Bjoern Peters; Joey Ting; Danh Do; Lo Vang; Jeff Alexander; Howard Grey; Michael J Buchmeier; Alessandro Sette
A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease.
PLoS pathogens 2009;5(12):e1000695.
2009: Stephen R Walsh; Jacqueline Gillis; Björn Peters; Bianca R Mothé; John Sidney; Alessandro Sette; R Paul Johnson
Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques.
Vaccine 2009;27(36):4990-5000.
2009: John T Loffredo; John Sidney; Alexander T Bean; Dominic Beal; Wilfried Bardet; Angela Wahl; Oriana E Hawkins; Shari M Piaskowski; Nancy A Wilson; William H Hildebrand; David Ian Watkins; Alessandro Sette
Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7763-75.
2009: Lauren E Yauch; Raphaël M Zellweger; Maya F Kotturi; Afrina Qutubuddin; John Sidney; Bjoern Peters; Tyler R Prestwood; Alessandro Sette; Sujan Shresta
A protective role for dengue virus-specific CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4865-73.
2009: Magdalini Moutaftsi; Shahram Salek-Ardakani; Michael Croft; Bjoern Peters; John Sidney; Howard Grey; Alessandro Sette
Correlates of protection efficacy induced by vaccinia virus-specific CD8+ T-cell epitopes in the murine intranasal challenge model.
European journal of immunology 2009;39(3):717-22.
2009: Yohan Kim; John Sidney; Clemencia Pinilla; Alessandro Sette; Bjoern Peters
Derivation of an amino acid similarity matrix for peptide: MHC binding and its application as a Bayesian prior.
BMC bioinformatics 2009;10():394.
2008: Alleluiah Rutebemberwa; Stuart C Ray; Jacquie Astemborski; Jordana Levine; Lin Liu; Kimberly A Dowd; Shalyn Clute; Changyu Wang; Alan Korman; Alessandro Sette; John Sidney; Drew M Pardoll; Andrea L Cox
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8215-25.
2008: Erika Assarsson; Huynh-Hoa Bui; John Sidney; Qing Zhang; Jean Glenn; Carla Oseroff; Innocent N Mbawuike; Jeff Alexander; Mark J Newman; Howard Grey; Alessandro Sette
Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humans.
Journal of virology 2008;82(24):12241-51.
2008: Courtney Dow; Carla Oseroff; Bjoern Peters; Courtney Nance-Sotelo; John Sidney; Michael J Buchmeier; Alessandro Sette; Bianca R Mothé
Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses.
Journal of virology 2008;82(23):11734-41.
2008: Matthias Wölfl; Alleluiah Rutebemberwa; Timothy Mosbruger; Qing Mao; Hong-mei Li; Dale Netski; Stuart C Ray; Drew M Pardoll; John Sidney; Alessandro Sette; Todd Allen; Thomas Kuntzen; Daniel G Kavanagh; Jürgen Kuball; Philip D Greenberg; Andrea L Cox
Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6435-46.
2008: Maya F Kotturi; Iain Scott; Tom Wolfe; Bjoern Peters; John Sidney; Hilde Cheroutre; Matthias G von Herrath; Michael J Buchmeier; Howard Grey; Alessandro Sette
Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):2124-33.
2008: Carla Oseroff; Bjoern Peters; Valerie Pasquetto; Magdalini Moutaftsi; John Sidney; Vijay Panchanathan; David C Tscharke; Bernard Maillere; Howard Grey; Alessandro Sette
Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(11):7193-202.
2008: Nicholas J Maness; Levi J Yant; Chungwon Chung; John T Loffredo; Thomas C Friedrich; Shari M Piaskowski; Jessica Furlott; Gemma E May; Taeko Soma; Enrique J León; Nancy A Wilson; Helen Piontkivska; Austin Hughes; John Sidney; Alessandro Sette; David Ian Watkins
Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.
Journal of virology 2008;82(11):5245-54.
2008: Arne Schneidewind; Mark Alan Brockman; John Sidney; Yaoyu E Wang; Huabiao Chen; Todd J Suscovich; Bin Li; Rahma I Adam; Rachel L Allgaier; Bianca R Mothé; Thomas Kuntzen; Cesar Oniangue-Ndza; Alicja Trocha; Xu G Yu; Christian Brander; Alessandro Sette; Bruce D Walker; Todd M Allen
Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.
Journal of virology 2008;82(11):5594-605.
2008: Peng Wang; John Sidney; Courtney Dow; Bianca R Mothé; Alessandro Sette; Bjoern Peters
A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach.
PLoS computational biology 2008;4(4):e1000048.
2008: Erika Assarsson; Jason A Greenbaum; Magnus Sundström; Lana Schaffer; Jennifer A Hammond; Valerie Pasquetto; Carla Oseroff; R Curtis Hendrickson; Elliot J Lefkowitz; David C Tscharke; John Sidney; Howard Grey; Steven R Head; Bjoern Peters; Alessandro Sette
Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(6):2140-5.
2008: John Sidney; Erika Assarsson; Carrie Moore; Sandy Ngo; Clemencia Pinilla; Alessandro Sette; Bjoern Peters
Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries.
Immunome research 2008;4():2.
2007: Nicholas J Maness; Laura E Valentine; Gemma E May; Jason Reed; Shari M Piaskowski; Taeko Soma; Jessica Furlott; Eva G Rakasz; Thomas C Friedrich; David A Price; Emma Gostick; Austin Hughes; John Sidney; Alessandro Sette; Nancy A Wilson; David Ian Watkins
AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape.
The Journal of experimental medicine 2007;204(11):2505-12.
2007: Nicole Frahm; Karina Yusim; Todd J Suscovich; Sharon Adams; John Sidney; Peter T Hraber; Hannah S Hewitt; Caitlyn H Linde; Daniel G Kavanagh; Tonia Woodberry; Leah M Henry; Kellie Faircloth; Jennifer Listgarten; Carl Kadie; Nebojsa Jojic; Kaori Sango; Nancy V Brown; Eunice Pae; M Tauheed Zaman; Florian Bihl; Ashok Khatri; Mina John; Simon Mallal; Francesco M Marincola; Bruce D Walker; Alessandro Sette; David Heckerman; Bette T Korber; Christian Brander
Extensive HLA class I allele promiscuity among viral CTL epitopes.
European journal of immunology 2007;37(9):2419-33.
2007: John Sidney; Bjoern Peters; Carrie Moore; Timothy J Pencille; Sandy Ngo; Kelly-Anne Masterman; Shinichi Asabe; Clemencia Pinilla; Francis V Chisari; Alesandro Sette
Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library.
Immunogenetics 2007;59(9):745-51.
2007: Erika Assarsson; John Sidney; Carla Oseroff; Valerie Pasquetto; Huynh-Hoa Bui; Nicole Frahm; Christian Brander; Bjoern Peters; Howard Grey; Alessandro Sette
A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7890-901.
2007: Magdalini Moutaftsi; Huynh-Hoa Bui; Bjoern Peters; John Sidney; Shahram Salek-Ardakani; Carla Oseroff; Valerie Pasquetto; Shane Crotty; Michael Croft; Elliot J Lefkowitz; Howard Grey; Alessandro Sette
Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(11):6814-20.
2007: Maya F Kotturi; Bjoern Peters; Fernando Buendia-Laysa; John Sidney; Carla Oseroff; Jason Botten; Howard Grey; Michael J Buchmeier; Alessandro Sette
The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus.
Journal of virology 2007;81(10):4928-40.
2007: Jason Botten; J Lindsay Whitton; Polly Barrowman; John Sidney; Jason K Whitmire; Jeff Alexander; Joey P C Ting; Huynh-Hoa Bui; Alessandro Sette; Michael J Buchmeier
HLA-A2-restricted protection against lethal lymphocytic choriomeningitis.
Journal of virology 2007;81(5):2307-17.
2007: John T Loffredo; Thomas C Friedrich; Enrique J León; Jason J Stephany; Denise S Rodrigues; Sean P Spencer; Alexander T Bean; Dominic Beal; Benjamin J Burwitz; Richard A Rudersdorf; Lyle T Wallace; Shari M Piaskowski; Gemma E May; John Sidney; Emma Gostick; Nancy A Wilson; David A Price; Esper Kallas; Helen Piontkivska; Austin Hughes; Alessandro Sette; David Ian Watkins
CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.
PloS one 2007;2(11):e1152.
2007: Huynh-Hoa Bui; John Sidney; Wei Li; Nicolas Fusseder; Alessandro Sette
Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines.
BMC bioinformatics 2007;8():361.
2006: Jason Botten; Jeff Alexander; Valerie Pasquetto; John Sidney; Polly Barrowman; Joey Ting; Bjoern Peters; Scott Southwood; Barbara Stewart; Maria P Rodriguez-Carreno; Bianca R Mothe; J Lindsay Whitton; Alessandro Sette; Michael J Buchmeier
Identification of protective Lassa virus epitopes that are restricted by HLA-A2.
Journal of virology 2006;80(17):8351-61.
2006: John Sidney; Shinichi Asabe; Bjoern Peters; Kelly-Anne Purton; Josan Chung; Timothy J Pencille; Robert Purcell; Christopher M Walker; Francis V Chisari; Alessandro Sette
Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules.
Immunogenetics 2006;58(7):559-70.
2006: Magdalini Moutaftsi; Bjoern Peters; Valerie Pasquetto; David C Tscharke; John Sidney; Huynh-Hoa Bui; Howard Grey; Alessandro Sette
A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus.
Nature biotechnology 2006;24(7):817-9.
2006: Bjoern Peters; Huynh-Hoa Bui; Sune Frankild; Morten Nielson; Claus Lundegaard; Emrah Kostem; Derek Basch; Kasper Lamberth; Mikkel Harndahl; Ward Fleri; Stephen S Wilson; John Sidney; Ole Lund; Soren Buus; Alessandro Sette
A community resource benchmarking predictions of peptide binding to MHC-I molecules.
PLoS computational biology 2006;2(6):e65.
2006: Florian Bihl; Nicole Frahm; Loriana Di Giammarino; John Sidney; Mina John; Karina Yusim; Tonia Woodberry; Kaori Sango; Hannah S Hewitt; Leah Henry; Caitlyn H Linde; John V Chisholm; Tauheed M Zaman; Eunice Pae; Simon Mallal; Bruce D Walker; Alessandro Sette; Bette T Korber; David Heckerman; Christian Brander
Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4094-101.
2006: Randi Vita; Kerrie Vaughan; Laura Zarebski; Nima Salimi; Ward Fleri; Howard Grey; Muthuraman Sathiamurthy; John Mokili; Huynh-Hoa Bui; Philip Bourne; Julia V Ponomarenko; romulo de castro; Russell K Chan; John Sidney; Stephen S Wilson; Scott Douglas Stewart; Scott Way; Bjoern Peters; Alessandro Sette
Curation of complex, context-dependent immunological data.
BMC bioinformatics 2006;7():341.
2006: Huynh-Hoa Bui; John Sidney; Kenny Dinh; Scott Southwood; Mark J Newman; Alessandro Sette
Predicting population coverage of T-cell epitope-based diagnostics and vaccines.
BMC bioinformatics 2006;7():153.
2005: John T Loffredo; John Sidney; Shari M Piaskowski; Andrew Szymanski; Jessica Furlott; Richard Rudersdorf; Jason Reed; Bjoern Peters; Heather D Hickman-Miller; Wilfried Bardet; William M Rehrauer; David O'Connor; Nancy A Wilson; William H Hildebrand; Alessandro Sette; David Ian Watkins
The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5986-97.
2005: Bjoern Peters; Huynh-Hoa Bui; John Sidney; Z Weng; John T Loffredo; David Ian Watkins; Bianca R Mothé; Alessandro Sette
A computational resource for the prediction of peptide binding to Indian rhesus macaque MHC class I molecules.
Vaccine 2005;23(45):5212-24.
2005: Valerie Pasquetto; Huynh-Hoa Bui; Rielle Giannino; Cindy Banh; Mirza Fareed; John Sidney; Carla Oseroff; David C Tscharke; Kari Irvine; Jack R Bennink; Bjoern Peters; Scott Southwood; Vincenzo Cerundolo; Howard Grey; jon yewdell; Alessandro Sette
HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5504-15.
2005: Carla Oseroff; FERDYNAND KOS; Huynh-Hoa Bui; Bjoern Peters; Valerie Pasquetto; Jean Glenn; Tara Palmore; John Sidney; David C Tscharke; Jack R Bennink; Scott Southwood; Howard Grey; jon yewdell; Alessandro Sette
HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13980-5.
2005: Muthuraman Sathiamurthy; Bjoern Peters; Huynh-Hoa Bui; John Sidney; John Mokili; Stephen S Wilson; Ward Fleri; Deborah L McGuinness; Philip Bourne; Alessandro Sette
An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities.
Immunome research 2005;1(1):2.
2005: julian schulze zur wiesch; Georg M Lauer; Cheryl L Day; Arthur Y Kim; Kei Ouchi; Jared E Duncan; Alysse Wurcel; Joerg Timm; Andrea M Jones; Bianca R Mothe; Todd M Allen; Barbara McGovern; Lia L Lewis-Ximenez; John Sidney; Alessandro Sette; Raymond T Chung; Bruce D Walker
Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):3603-13.
2005: John Sidney; Scott Southwood; Alessandro Sette
Classification of A1- and A24-supertype molecules by analysis of their MHC-peptide binding repertoires.
Immunogenetics 2005;57(6):393-408.
2005: Bjoern Peters; John Sidney; Phil Bourne; Huynh-Hoa Bui; Soren Buus; Grace Doh; Ward Fleri; Mitch Kronenberg; Ralph Kubo; Ole Lund; David Nemazee; Julia V Ponomarenko; Muthuraman Sathiamurthy; Stephen P Schoenberger; Scott Douglas Stewart; Pamela Surko; Scott Way; Steve Wilson; Alessandro Sette
The design and implementation of the immune epitope database and analysis resource.
Immunogenetics 2005;57(5):326-36.
2005: Huynh-Hoa Bui; John Sidney; Bjoern Peters; Muthuraman Sathiamurthy; Asabe Sinichi; Kelly-Anne Purton; Bianca R Mothé; Francis V Chisari; David Ian Watkins; Alessandro Sette
Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications.
Immunogenetics 2005;57(5):304-14.
2005: Marcus Altfeld; Todd M Allen; Elizabeth T Kalife; Nicole Frahm; Marylyn M Addo; Bianca R Mothe; Almas Rathod; Laura L Reyor; Jason Harlow; Xu G Yu; Beth Perkins; Loren K Robinson; John Sidney; Galit Alter; Mathias Lichterfeld; Alessandro Sette; Eric S Rosenberg; Philip J R Goulder; Christian Brander; Bruce D Walker
The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.
Journal of virology 2005;79(8):5000-5.
2005: Alessandro Sette; John Sidney; Huynh-Hoa Bui; Marie-France del Guercio; Jeff Alexander; John T Loffredo; David Ian Watkins; Bianca R Mothé
Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity.
Immunogenetics 2005;57(1-2):53-68.
2005: Shabnam Tangri; Bianca R Mothé; Julie Eisenbraun; John Sidney; Scott Southwood; Kristen Briggs; John Zinckgraf; Pamuk Bilsel; Mark Newman; Robert W Chesnut; Cynthia Licalsi; Alessandro Sette
Rationally engineered therapeutic proteins with reduced immunogenicity.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3187-96.
2005: Bjoern Peters; John Sidney; Phil Bourne; Huynh-Hoa Bui; Soren Buus; Grace Doh; Ward Fleri; Mitch Kronenberg; Ralph Kubo; Ole Lund; David Nemazee; Julia V Ponomarenko; Muthuraman Sathiamurthy; Stephen P Schoenberger; Scott Douglas Stewart; Pamela Surko; Scott Way; Steve Wilson; Alessandro Sette
The immune epitope database and analysis resource: from vision to blueprint.
PLoS biology 2005;3(3):e91.
2004: John T Loffredo; John Sidney; Christina Wojewoda; Elizabeth J Dodds; Matthew R Reynolds; Gnankang Napoé; Bianca R Mothé; David O'Connor; Nancy A Wilson; David Ian Watkins; Alessandro Sette
Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5064-76.
2004: Daniel E Kaufmann; Paul M Bailey; John Sidney; Bradford Wagner; Philip J Norris; Mary N Johnston; Lisa A Cosimi; Marylyn M Addo; Mathias Lichterfeld; Marcus Altfeld; Nicole Frahm; Christian Brander; Alessandro Sette; Bruce D Walker; Eric S Rosenberg
Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.
Journal of virology 2004;78(9):4463-77.
2004: Silvia Vertuani; Alessandro Sette; John Sidney; Scott Southwood; John Fikes; Elissa Keogh; Jan Alvar Lindencrona; Glenn Ishioka; Jelena Levitskaya; Rolf Kiessling
Improved immunogenicity of an immunodominant epitope of the HER-2/neu protooncogene by alterations of MHC contact residues.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(6):3501-8.
2004: Thomas C Friedrich; Elizabeth J Dodds; Levi J Yant; Lara Vojnov; Richard Rudersdorf; Candice Cullen; David T Evans; Ronald C Desrosiers; Bianca R Mothé; John Sidney; Alessandro Sette; Kevin Kunstman; Steven Wolinsky; Michael Piatak; Jeffrey D Lifson; Austin Hughes; Nancy Wilson; David O'Connor; David Ian Watkins
Reversion of CTL escape-variant immunodeficiency viruses in vivo.
Nature medicine 2004;10(3):275-81.
2004: Naglaa H Shoukry; John Sidney; Alessandro Sette; Christopher M Walker
Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(1):483-92.
2003: John Sidney; Scott Southwood; Valerie Pasquetto; Alessandro Sette
Simultaneous prediction of binding capacity for multiple molecules of the HLA B44 supertype.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(11):5964-74.
2003: Denise L Doolan; Scott Southwood; Daniel A Freilich; John Sidney; Norma L Graber; Lori Shatney; Lolita Bebris; Laurence Florens; Carlota Dobano; Adam A Witney; Ettore Appella; Stephen L Hoffman; John R Yates; Daniel J Carucci; Alessandro Sette
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(17):9952-7.
2003: Alessandro Sette; John Sidney; Brian D Livingston; John Dzuris; Claire Crimi; Christopher M Walker; Scott Southwood; Edward J Collins; Austin Hughes
Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution.
Immunogenetics 2003;54(12):830-41.
2002: Shabnam Tangri; Cynthia Licalsi; John Sidney; Alessandro Sette
Rationally engineered proteins or antibodies with absent or reduced immunogenicity.
Current medicinal chemistry 2002;9(24):2191-9.
2002: John Sidney; Marie-France del Guercio; Scott Southwood; Alessandro Sette
The HLA molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5098-108.
2002: Thorsten U Vogel; Thomas C Friedrich; David O'Connor; William M Rehrauer; Elizabeth J Dodds; Heather D Hickman; William H Hildebrand; John Sidney; Alessandro Sette; Austin Hughes; Helen Horton; Kathy Vielhuber; Richard Rudersdorf; Ivna P De Souza; Matthew R Reynolds; Todd M Allen; Nancy Wilson; David Ian Watkins
Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence?
Journal of virology 2002;76(22):11623-36.
2002: Bianca R Mothé; John Sidney; John Dzuris; Max E Liebl; Sarah Fuenger; David Ian Watkins; Alessandro Sette
Characterization of the peptide-binding specificity of Mamu-B*17 and identification of Mamu-B*17-restricted epitopes derived from simian immunodeficiency virus proteins.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):210-9.
2002: Alessandro Sette; Mark Newman; Brian D Livingston; Denise McKinney; John Sidney; Glenn Ishioka; Shabnam Tangri; Jeff Alexander; John Fikes; Robert W Chesnut
Optimizing vaccine design for cellular processing, MHC binding and TCR recognition.
Tissue antigens 2002;59(6):443-51.
2002: Brian D Livingston; Claire Crimi; Mark Newman; Yuichiro Higashimoto; Ettore Appella; John Sidney; Alessandro Sette
A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(11):5499-506.
2002: Alessandro Sette; Elissa Keogh; Glenn Ishioka; John Sidney; Shabnam Tangri; Brian D Livingston; Denise McKinney; Mark Newman; Robert W Chesnut; John Fikes
Epitope identification and vaccine design for cancer immunotherapy.
Current opinion in investigational drugs (London, England : 2000) 2002;3(1):132-9.
2001: AL Erickson; Y Kimura; S Igarashi; J Eichelberger; Michael Houghton; John Sidney; Denise McKinney; Alessandro Sette; Austin Hughes; Christopher M Walker
The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.
Immunity 2001;15(6):883-95.
2001: John Sidney; Scott Southwood; Dean L Mann; M A Fernandez-Vina; Mark J Newman; Alessandro Sette
Majority of peptides binding HLA-A*0201 with high affinity crossreact with other A2-supertype molecules.
Human immunology 2001;62(11):1200-16.
2001: John Dzuris; John Sidney; Helen Horton; R Correa; D Carter; Robert W Chesnut; David Ian Watkins; Alessandro Sette
Molecular determinants of peptide binding to two common rhesus macaque major histocompatibility complex class II molecules.
Journal of virology 2001;75(22):10958-68.
2001: Shabnam Tangri; Glenn Ishioka; X Huang; John Sidney; Scott Southwood; John Fikes; Alessandro Sette
Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide.
The Journal of experimental medicine 2001;194(6):833-46.
2001: Alessandro Sette; Brian D Livingston; Denise McKinney; Ettore Appella; John Fikes; John Sidney; Mark Newman; Robert W Chesnut
The development of multi-epitope vaccines: epitope identification, vaccine design and clinical evaluation.
Biologicals : journal of the International Association of Biological Standardization 2001;29(3-4):271-6.
2001: Cara C Wilson; B Palmer; Scott Southwood; John Sidney; Y Higashimoto; Ettore Appella; Robert W Chesnut; Alessandro Sette; Brian D Livingston
Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes.
Journal of virology 2001;75(9):4195-207.
2001: Anita Kumar; Sanjai Kumar; Thong P Le; Scott Southwood; John Sidney; Joe Cohen; Alessandro Sette; Stephen L Hoffman
HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein.
Infection and immunity 2001;69(4):2766-71.
2001: Marcus Altfeld; Brian D Livingston; N Reshamwala; Phuong Thi Nguyen; Marylyn M Addo; AK Shea; M Newman; John Fikes; John Sidney; PA Wentworth; Robert W Chesnut; Robert L Eldridge; Eric S Rosenberg; Gregory Robbins; Christian Brander; PE Sax; SL Boswell; Theresa Flynn; Susan Buchbinder; Philip J R Goulder; Bruce D Walker; Alessandro Sette; Spyros A Kalams
Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
Journal of virology 2001;75(3):1301-11.
2001: Alessandro Sette; Carla Oseroff; John Sidney; J Alexander; Robert W Chesnut; Kazuhiro Kakimi; Luca G Guidotti; Francis V Chisari
Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1389-97.
2001: Todd M Allen; Bianca R Mothé; John Sidney; Peicheng Jing; John Dzuris; Max E Liebl; Thorsten U Vogel; David O'Connor; X Wang; M C Wussow; J A Thomson; John D Altman; David Ian Watkins; Alessandro Sette
CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing.
Journal of virology 2001;75(2):738-49.
2000: John Sidney; John Dzuris; M J Newman; R P Johnson; A Kaur; K Amitinder; C M Walker; E Appella; Bianca R Mothe; David Ian Watkins; Alessandro Sette
Definition of the Mamu A*01 peptide binding specificity: application to the identification of wild-type and optimized ligands from simian immunodeficiency virus regulatory proteins.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6387-99.
2000: Denise McKinney; AL Erickson; Christopher M Walker; R Thimme; F V Chisari; John Sidney; Alessandro Sette
Identification of five different Patr class I molecules that bind HLA supertype peptides and definition of their peptide binding motifs.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4414-22.
2000: Denise L Doolan; Scott Southwood; Robert W Chesnut; Ettore Appella; E Gomez; A Richards; Y I Higashimoto; Ajesh Maewal; John Sidney; Robert A Gramzinski; Carl Mason; D Koech; Stephen L Hoffman; Alessandro Sette
HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):1123-37.
2000: C Gianfrani; Carla Oseroff; John Sidney; Robert W Chesnut; Alessandro Sette
Human memory CTL response specific for influenza A virus is broad and multispecific.
Human immunology 2000;61(5):438-52.
2000: John Dzuris; John Sidney; E Appella; Robert W Chesnut; David Ian Watkins; Alessandro Sette
Conserved MHC class I peptide binding motif between humans and rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(1):283-91.
1999: Brian D Livingston; Claire Crimi; John Fikes; Robert W Chesnut; John Sidney; Alessandro Sette
Immunization with the HBV core 18-27 epitope elicits CTL responses in humans expressing different HLA-A2 supertype molecules.
Human immunology 1999;60(11):1013-7.
1999: David T Evans; David O'Connor; Peicheng Jing; John Dzuris; John Sidney; J da Silva; Todd M Allen; Helen Horton; J E Venham; RA Rudersdorf; T Vogel; C. David Pauza; Ronald E Bontrop; R DeMars; Alessandro Sette; Austin Hughes; David Ian Watkins
Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef.
Nature medicine 1999;5(11):1270-6.
1999: K M Chang; Norbert H Gruener; Scott Southwood; John Sidney; G R Pape; Francis V Chisari; Alessandro Sette
Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(2):1156-64.
1998: Alessandro Sette; John Sidney
HLA supertypes and supermotifs: a functional perspective on HLA polymorphism.
Current opinion in immunology 1998;10(4):478-82.
1998: Todd M Allen; John Sidney; M F del Guercio; R L Glickman; Gary L Lensmeyer; D A Wiebe; R DeMars; C. David Pauza; R P Johnson; Alessandro Sette; David Ian Watkins
Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):6062-71.
1998: Scott Southwood; John Sidney; A Kondo; Marie-France del Guercio; Ettore Appella; S Hoffman; RT Kubo; Robert W Chesnut; Howard Grey; Alessandro Sette
Several common HLA-DR types share largely overlapping peptide binding repertoires.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3363-73.
1998: Robbert van der Most; Kaja Murali-Krishna; J L Whitton; Carla Oseroff; J Alexander; Scott Southwood; John Sidney; Robert W Chesnut; Alessandro Sette; Rafi Ahmed
Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice.
Virology 1998;240(1):158-67.
1997: Jeff Alexander; Carla Oseroff; John Sidney; PA Wentworth; E Keogh; G Hermanson; Francis V Chisari; RT Kubo; Howard Grey; Alessandro Sette
Derivation of HLA-A11/Kb transgenic mice: functional CTL repertoire and recognition of human A11-restricted CTL epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4753-61.
1997: John Sidney; Marie-France del Guercio; Scott Southwood; G Hermanson; Ajesh Maewal; Ettore Appella; Alessandro Sette
The HLA-A*0207 peptide binding repertoire is limited to a subset of the A*0201 repertoire.
Human immunology 1997;58(1):12-20.
1997: S C Threlkeld; PA Wentworth; Spyros A Kalams; BM Wilkes; DJ Ruhl; Elissa Keogh; John Sidney; Scott Southwood; Bruce D Walker; Alessandro Sette
Degenerate and promiscuous recognition by CTL of peptides presented by the MHC class I A3-like superfamily: implications for vaccine development.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(4):1648-57.
1997: Denise L Doolan; Stephen L Hoffman; Scott Southwood; PA Wentworth; John Sidney; Robert W Chesnut; Elissa Keogh; E Appella; T B Nutman; A A Lal; Daniel M Gordon; James OLOO; Alessandro Sette
Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles.
Immunity 1997;7(1):97-112.
1997: Robbert van der Most; R J Concepcion; Carla Oseroff; J Alexander; Scott Southwood; John Sidney; Robert W Chesnut; Rafi Ahmed; Alessandro Sette
Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice.
Journal of virology 1997;71(7):5110-4.
1997: Antonella Vitiello; A Sette; L Yuan; P Farness; Scott Southwood; John Sidney; Robert W Chesnut; Howard Grey; Brian D Livingston
Comparison of cytotoxic T lymphocyte responses induced by peptide or DNA immunization: implications on immunogenicity and immunodominance.
European journal of immunology 1997;27(3):671-8.
1997: V Tsai; Scott Southwood; John Sidney; K Sakaguchi; Y Kawakami; Ettore Appella; Alessandro Sette; E Celis
Identification of subdominant CTL epitopes of the GP100 melanoma-associated tumor antigen by primary in vitro immunization with peptide-pulsed dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1796-802.
1997: A Kondo; John Sidney; Scott Southwood; Marie-France del Guercio; Ettore Appella; H Sakamoto; Howard Grey; E Celis; Robert W Chesnut; RT Kubo; Alessandro Sette
Two distinct HLA-A*0101-specific submotifs illustrate alternative peptide binding modes.
Immunogenetics 1997;45(4):249-58.
1996: Antonella Vitiello; L Yuan; Robert W Chesnut; John Sidney; Scott Southwood; P Farness; MR Jackson; PA Peterson; Alessandro Sette
Immunodominance analysis of CTL responses to influenza PR8 virus reveals two new dominant and subdominant Kb-restricted epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5555-62.
1996: Robbert van der Most; Alessandro Sette; Carla Oseroff; J Alexander; Kaja Murali-Krishna; L L Lau; Scott Southwood; John Sidney; Robert W Chesnut; M Matloubian; Rafi Ahmed
Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5543-54.
1996: John Sidney; Scott Southwood; Marie-France del Guercio; Howard Grey; Robert W Chesnut; RT Kubo; Alessandro Sette
Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(8):3480-90.
1996: PA Wentworth; Alessandro Sette; E Celis; John Sidney; Scott Southwood; Claire Crimi; S Stitely; Elissa Keogh; N C Wong; Brian D Livingston; D Alazard; Antonella Vitiello; Howard Grey; Francis V Chisari; Robert W Chesnut; John Fikes
Identification of A2-restricted hepatitis C virus-specific cytotoxic T lymphocyte epitopes from conserved regions of the viral genome.
International immunology 1996;8(5):651-9.
1996: John Sidney; Howard Grey; Scott Southwood; E Celis; PA Wentworth; Marie-France del Guercio; RT Kubo; Robert W Chesnut; Alessandro Sette
Definition of an HLA-A3-like supermotif demonstrates the overlapping peptide-binding repertoires of common HLA molecules.
Human immunology 1996;45(2):79-93.
1996: PA Wentworth; Antonella Vitiello; John Sidney; Elissa Keogh; Robert W Chesnut; Howard Grey; Alessandro Sette
Differences and similarities in the A2.1-restricted cytotoxic T cell repertoire in humans and human leukocyte antigen-transgenic mice.
European journal of immunology 1996;26(1):97-101.
1995: A Kondo; John Sidney; Scott Southwood; Marie-France del Guercio; Ettore Appella; H Sakamoto; E Celis; Howard Grey; Robert W Chesnut; RT Kubo; Alessandro Sette
Prominent roles of secondary anchor residues in peptide binding to HLA-A24 human class I molecules.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4307-12.
1995: M Bocchia; PA Wentworth; Scott Southwood; John Sidney; K McGraw; David A Scheinberg; Alessandro Sette
Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules.
Blood 1995;85(10):2680-4.
1995: B Rehermann; P Fowler; John Sidney; J Person; Allan Redeker; M Brown; Bernard Moss; Alessandro Sette; Francis V Chisari
The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis.
The Journal of experimental medicine 1995;181(3):1047-58.
1995: Marie-France del Guercio; John Sidney; G Hermanson; C Perez; Howard Grey; RT Kubo; Alessandro Sette
Binding of a peptide antigen to multiple HLA alleles allows definition of an A2-like supertype.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(2):685-93.
1995: Howard Grey; J Ruppert; Antonella Vitiello; John Sidney; W Martin Kast; RT Kubo; Alessandro Sette
Class I MHC-peptide interactions: structural requirements and functional implications.
Cancer surveys 1995;22():37-49.
1995: John Sidney; Marie-France del Guercio; Scott Southwood; V H Engelhard; Ettore Appella; H G Rammensee; K Falk; O Rötzschke; M Takiguchi; RT Kubo
Several HLA alleles share overlapping peptide specificities.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):247-59.
1994: Alessandro Sette; Antonella Vitiello; B Reherman; P Fowler; R Nayersina; W Martin Kast; Cornelis J M Melief; Carla Oseroff; L Yuan; J Ruppert; John Sidney; Marie-France del Guercio; Scott Southwood; RT Kubo; Robert W Chesnut; Howard Grey; Francis V Chisari
The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5586-92.
1994: Jeff Alexander; John Sidney; Scott Southwood; J Ruppert; Carla Oseroff; Ajesh Maewal; K Snoke; H M Serra; RT Kubo; Alessandro Sette
Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides.
Immunity 1994;1(9):751-61.
1994: E Celis; John Fikes; PA Wentworth; John Sidney; Scott Southwood; Ajesh Maewal; Marie-France del Guercio; Alessandro Sette; Brian D Livingston
Identification of potential CTL epitopes of tumor-associated antigen MAGE-1 for five common HLA-A alleles.
Molecular immunology 1994;31(18):1423-30.
1994: Alessandro Sette; John Sidney; Marie-France del Guercio; Scott Southwood; J Ruppert; Carol Dahlberg; Howard Grey; RT Kubo
Peptide binding to the most frequent HLA-A class I alleles measured by quantitative molecular binding assays.
Molecular immunology 1994;31(11):813-22.
1994: J Ruppert; RT Kubo; John Sidney; Howard Grey; Alessandro Sette
Class I MHC-peptide interaction: structural and functional aspects.
Behring Institute Mitteilungen 1994;(94):48-60.
1994: John Sidney; Carla Oseroff; Marie-France del Guercio; Scott Southwood; J I Krieger; Glenn Ishioka; K Sakaguchi; E Appella; Alessandro Sette
Definition of a DQ3.1-specific binding motif.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(9):4516-25.
1993: Alessandro Sette; John Sidney; Carla Oseroff; Marie-France del Guercio; Scott Southwood; T Arrhenius; M F Powell; S M Colón; F C Gaeta; Howard Grey
HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(6):3163-70.
1993: J Ruppert; John Sidney; E Celis; RT Kubo; Howard Grey; Alessandro Sette
Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 molecules.
Cell 1993;74(5):929-37.
1993: Alessandro Sette; John Sidney; F C Gaeta; E Appella; S M Colón; Marie-France del Guercio; J C Guéry; L Adorini
MHC class II molecules bind indiscriminately self and non-self peptide homologs: effect on the immunogenicity of non-self peptides.
International immunology 1993;5(6):631-8.
1993: A Valli; A Sette; L Kappos; Carla Oseroff; John Sidney; GC Miescher; M Hochberger; Ekkehard D Albert; Luciano Adorini
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
The Journal of clinical investigation 1993;91(2):616-28.
1993: Jeff Alexander; K Snoke; J Ruppert; John Sidney; M Wall; Scott Southwood; Carla Oseroff; T Arrhenius; F C Gaeta; S M Colón
Functional consequences of engagement of the T cell receptor by low affinity ligands.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):1-7.
1992: John Sidney; Carla Oseroff; Scott Southwood; M Wall; Glenn Ishioka; F Koning; Alessandro Sette
DRB1*0301 molecules recognize a structural motif distinct from the one recognized by most DR beta 1 alleles.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2634-40.
1992: M Wall; Scott Southwood; John Sidney; Carla Oseroff; M F del Guericio; A G Lamont; S M Colón; T Arrhenius; F C Gaeta; Alessandro Sette
High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants.
International immunology 1992;4(7):773-7.
1992: Alessandro Sette; Scott Southwood; D O'Sullivan; F C Gaeta; John Sidney; Howard Grey
Effect of pH on MHC class II-peptide interactions.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(3):844-51.
1991: Alessandro Sette; Antonella Vitiello; P Farness; J Furze; John Sidney; J M Claverie; Howard Grey; R Chesnut
Random association between the peptide repertoire of A2.1 class I and several different DR class II molecules.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3893-900.
1991: D O'Sullivan; T Arrhenius; John Sidney; Marie-France del Guercio; M Albertson; M Wall; Carla Oseroff; Scott Southwood; S M Colón; F C Gaeta
On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(8):2663-9.
1991: J Leighton; A Sette; John Sidney; E Appella; C Ehrhardt; S Fuchs; Luciano Adorini
Comparison of structural requirements for interaction of the same peptide with I-Ek and I-Ed molecules in the activation of MHC class II-restricted T cells.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(1):198-204.
1991: J I Krieger; R W Karr; Howard Grey; W Y Yu; D O'Sullivan; L Batovsky; Z L Zheng; S M Colón; F C Gaeta; John Sidney
Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2331-40.
1991: D O'Sullivan; John Sidney; Marie-France del Guercio; S M Colón; Alessandro Sette
Truncation analysis of several DR binding epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1240-6.
1990: D O'Sullivan; John Sidney; E Appella; L Walker; L Phillips; S M Colón; C Miles; Robert W Chesnut; Alessandro Sette
Characterization of the specificity of peptide binding to four DR haplotypes.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1799-808.
1990: Alessandro Sette; John Sidney; M Albertson; C Miles; S M Colón; T Pedrazzini; A G Lamont; Howard Grey
A novel approach to the generation of high affinity class II-binding peptides.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(6):1809-13.