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Sandra Siedlak

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Xiongwei Zhu; Gjumrakch Aliev; Rudy J Castellani; Hisashi Fujioka; Peggy L R Harris; Paula I Moreira; Lawrence M Sayre; Justin Shenk; Sandra L Siedlak; Mark A Smith; Luke I Szweda; Pamela A Szweda; George Perry
Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Rudy J Castellani; Jeff M Coller; Yashi Gupta; Peggy Lr Harris; Hyoung-gon Lee; George Perry; Baiyang Sheng; Sandra L Siedlak; Mark A Smith; Massimo Tabaton; Xinglong Wang; Xiongwei Zhu
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Vladan P Bajić; Ninoslav Djelic; Lara M Fahmy; Wataru Kudo; Hyoung-gon Lee; Zorana Milicevic; Sandra L Siedlak; Avneet K Singh; Mark A. Smith; Biljana Spremo-Potparević; Bo Su; Xinglong Wang; Lada Zivković; Xiongwei Zhu
Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease.

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All Publications

2012: Xiongwei Zhu; Gjumrakch Aliev; Rudy J Castellani; Hisashi Fujioka; Peggy L R Harris; Paula I Moreira; Lawrence M Sayre; Justin Shenk; Sandra L Siedlak; Mark A Smith; Luke I Szweda; Pamela A Szweda; George Perry
Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.
Free radical biology & medicine 2012;52(3):699-704.
2011: Rudy J Castellani; Jeff M Coller; Yashi Gupta; Peggy Lr Harris; Hyoung-gon Lee; George Perry; Baiyang Sheng; Sandra L Siedlak; Mark A Smith; Massimo Tabaton; Xinglong Wang; Xiongwei Zhu
A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules.
Laboratory investigation; a journal of technical methods and pathology 2011;91(12):1777-86.
2011: Vladan P Bajić; Ninoslav Djelic; Lara M Fahmy; Wataru Kudo; Hyoung-gon Lee; Zorana Milicevic; Sandra L Siedlak; Avneet K Singh; Mark A. Smith; Biljana Spremo-Potparević; Bo Su; Xinglong Wang; Lada Zivković; Xiongwei Zhu
Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease.
Cellular & molecular biology letters 2011;16(3):359-72.
2011: Jeremy G Stone; Massimo Tabaton; Xiongwei Zhu; Rudy J Castellani; Asao Hirano; George Perry; Corrado Santocanale; Sandra L Siedlak; Mark A. Smith; Hyoung-gon Lee
The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies.
Journal of neuropathology and experimental neurology 2011;70(7):578-87.
2011: William H Hoffman; Sandra L Siedlak; Yang Wang; Rudy J Castellani; Mark A. Smith
Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis.
Brain research 2011;1369():194-202.
2011: Jeremy G Stone; Xinglong Wang; Xiongwei Zhu; Gemma Casadesus Smith; Rudy J Castellani; Kasia Gustaw-Rothenberg; George Perry; Sandra L Siedlak; Mark A Smith
Frontiers in Alzheimer's disease therapeutics.
Therapeutic advances in chronic disease 2011;2(1):9-23.
2010: Lada Zivković; Biljana Spremo-Potparević; Bosiljka Plecas-Solarović; Ninoslav Djelić; Gordana Ocić; Predrag Smiljković; Sandra L Siedlak; Mark A. Smith; Vladan Bajić
Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.
The journals of gerontology. Series A, Biological sciences and medical sciences 2010;65(12):1269-74.
2010: Gavin A Buxton; Sandra L Siedlak; George Perry; Mark A. Smith
Mathematical modeling of microtubule dynamics: insights into physiology and disease.
Progress in neurobiology 2010;92(4):478-83.
2010: Jonathon E Heath; Sandra L Siedlak; Xiongwei Zhu; Hyoung-gon Lee; Akanksha Thakur; Riqiang Yan; George Perry; Mark A. Smith; Rudy J Castellani
Widespread distribution of reticulon-3 in various neurodegenerative diseases.
Neuropathology : official journal of the Japanese Society of Neuropathology 2010;30(6):574-9.
2010: Calvin F Moh; Sandra L Siedlak; Massimo Tabaton; George Perry; Rudy J Castellani; Mark A. Smith
Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease.
Journal of neuroscience methods 2010;190(2):244-7.
2010: David J Bonda; Maneesh Mailankot; Jeremy G Stone; Matthew R Garrett; Magdalena Staniszewska; Rudy J Castellani; Sandra L Siedlak; Xiongwei Zhu; Hyoung-gon Lee; George Perry; Ram H Nagaraj; Mark A. Smith
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease.
Redox report : communications in free radical research 2010;15(4):161-8.
2010: Burkhard Poeggeler; Kumar Sambamurti; Sandra L Siedlak; George Perry; Mark A. Smith; Miguel A Pappolla
A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan.
PloS one 2010;5(4):e10206.
2010: Mark A. Smith; Xiongwei Zhu; Massimo Tabaton; Gang Liu; Daniel W McKeel; Mark L Cohen; Xinglong Wang; Sandra L Siedlak; Barney E Dwyer; Takaaki Hayashi; Masao Nakamura; Akihiko Nunomura; George Perry
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.
Journal of Alzheimer's disease : JAD 2010;19(1):363-72.
2010: Katarzyna A Gustaw-Rothenberg; Sandra L Siedlak; David J Bonda; Alan Lerner; Massimo Tabaton; George Perry; Mark A. Smith
Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study.
Experimental gerontology 2010;45(1):47-52.
2009: George Perry; Paula I Moreira; Sandra L Siedlak; Akihiko Nunomura; Xiongwei Zhu; Mark A. Smith
Natural oxidant balance in Parkinson disease.
Archives of neurology 2009;66(12):1445.
2009: Vladan P Bajić; Biljana Spremo-Potparević; Lada Zivković; David J Bonda; Sandra L Siedlak; Gemma Casadesus Smith; Hyoung-gon Lee; Mark A. Smith
The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?
Medical hypotheses 2009;73(6):917-20.
2009: David J Bonda; Teresa A Evans; Corrado Santocanale; Jesús Catalá Llosá; Jose Viña; Bajic Vladan; Rudy J Castellani; Sandra L Siedlak; George Perry; Mark A. Smith; Hyoung-gon Lee
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease.
Aging 2009;1(4):382-8.
2009: Sandra L Siedlak; Gemma Casadesus Smith; Kate M Webber; Miguel Pappolla; Craig S Atwood; Mark A. Smith; George Perry
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Free radical research 2009;43(2):156-64.
2009: Hyoung-gon Lee; Qun Chen; Julie A Wolfram; Sandy L Richardson; Anna Liner; Sandra L Siedlak; Xiongwei Zhu; Nicholas P Ziats; Hisashi Fujioka; Dean W Felsher; Rudy J Castellani; Maria L Valencik; John A McDonald; Brian D Hoit; Edward J Lesnefsky; Mark A. Smith
Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure.
PloS one 2009;4(9):e7172.
2009: Bo Su; Haihua Liu; Xinglong Wang; Shu G Chen; Sandra L Siedlak; Eisaku Kondo; Raymond Choi; Atsushi Takeda; Rudy J Castellani; George Perry; Mark A. Smith; Xiongwei Zhu; Hyoung-gon Lee
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease.
Molecular neurodegeneration 2009;4():32.
2009: Rudy J Castellani; Hyoung-gon Lee; Sandra L Siedlak; Akihiko Nunomura; Takaaki Hayashi; Masao Nakamura; Xiongwei Zhu; George Perry; Mark A. Smith
Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.
Journal of Alzheimer's disease : JAD 2009;18(2):447-52.
2008: Xinglong Wang; Bo Su; Sandra L Siedlak; Paula I Moreira; Hisashi Fujioka; Yang Wang; Gemma Casadesus Smith; Xiongwei Zhu
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(49):19318-23.
2008: Na-Hye Myung; Xiongwei Zhu; Inna I Kruman; Rudy J Castellani; Robert B Petersen; Sandra L Siedlak; George Perry; Mark A. Smith; Hyoung-gon Lee
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Age (Dordrecht, Netherlands) 2008;30(4):209-15.
2008: Luis F Gonzalez-Cuyar; George Perry; Hiroaki Miyajima; Craig S Atwood; Marcela Riveros-Angel; Patrick F Lyons; Sandra L Siedlak; Mark A. Smith; Rudy J Castellani
Redox active iron accumulation in aceruloplasminemia.
Neuropathology : official journal of the Japanese Society of Neuropathology 2008;28(5):466-71.
2008: Katarzyna A Gustaw; Matthew R Garrett; Hyoung-gon Lee; Rudy J Castellani; Michael G Zagorski; Annamalai Prakasam; Sandra L Siedlak; Xiongwei Zhu; George Perry; Robert B Petersen; Robert P Friedland; Mark A. Smith
Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis.
Journal of neurochemistry 2008;106(3):1350-6.
2008: Joanna Collingwood; Ryan K K Chong; Takeshi Kasama; Lionel Cervera-Gontard; Rafal E Dunin-Borkowski; George Perry; Mihály Pósfai; Sandra L Siedlak; Edward T Simpson; Mark A. Smith; Jon Dobson
Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material.
Journal of Alzheimer's disease : JAD 2008;14(2):235-45.
2008: Akanksha Thakur; Sandra L Siedlak; Sheronica L James; David J Bonda; Akanksha Rao; Kate M Webber; Antoni Camins; Merce Pallas; Gemma Casadesus Smith; Hyoung-gon Lee; Robert Bowser; Arun K Raina; George Perry; Mark A. Smith; Xiongwei Zhu
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
International journal of clinical and experimental pathology 2008;1(2):134-46.
2008: George Perry; Xiongwei Zhu; Asim K Babar; Sandra L Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; Shu G Chen
Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies.
Neuro-degenerative diseases 2008;5(3-4):222-4.
2007: Paula I Moreira; Sandra L Siedlak; Xinglong Wang; Maria S Santos; Catarina R Oliveira; Massimo Tabaton; Akihiko Nunomura; Luke I Szweda; Gjumrakch Aliev; Mark A. Smith; Xiongwei Zhu; George Perry
Increased autophagic degradation of mitochondria in Alzheimer disease.
Autophagy 2007;3(6):614-5.
2007: Xiongwei Zhu; Mark A. Smith; Kazuhiro Honda; Gjumrakch Aliev; Paula I Moreira; Akihiko Nunomura; Gemma Casadesus Smith; Peggy L R Harris; Sandra L Siedlak; George Perry
Vascular oxidative stress in Alzheimer disease.
Journal of the neurological sciences 2007;257(1-2):240-6.
2007: Paula I Moreira; Sandra L Siedlak; Xinglong Wang; Maria S Santos; Catarina R Oliveira; Massimo Tabaton; Akihiko Nunomura; Luke I Szweda; Gjumrakch Aliev; Mark A. Smith; Xiongwei Zhu; George Perry
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Journal of neuropathology and experimental neurology 2007;66(6):525-32.
2007: Akanksha Thakur; Xinglong Wang; Sandra L Siedlak; George Perry; Mark A. Smith; Xiongwei Zhu
c-Jun phosphorylation in Alzheimer disease.
Journal of neuroscience research 2007;85(8):1668-73.
2007: Gemma Casadesus Smith; Paula I Moreira; Akihiko Nunomura; Sandra L Siedlak; William Bligh-Glover; Elizabeth Balraj; Grace J Petot; Mark A. Smith; George Perry
Indices of metabolic dysfunction and oxidative stress.
Neurochemical research 2007;32(4-5):717-22.
2007: Gemma Casadesus Smith; Mark A. Smith; Samar Basu; Jing Hua; Dae E Capobianco; Sandra L Siedlak; Xiongwei Zhu; George Perry
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease.
Molecular neurodegeneration 2007;2():2.
2006: Matthew Mei; Bo Su; Kristen Harrison; Mark Chao; Sandra L Siedlak; Laura A Previll; LaMia Jackson; Dan X Cai; Xiongwei Zhu
Distribution, levels and phosphorylation of Raf-1 in Alzheimer's disease.
Journal of neurochemistry 2006;99(5):1377-88.
2006: Xiongwei Zhu; Sandra L Siedlak; Mark A. Smith; George Perry; Shu G Chen
LRRK2 protein is a component of Lewy bodies.
Annals of neurology 2006;60(5):617-8; author reply 618-9.
2006: Mark E Obrenovich; Mark A. Smith; Sandra L Siedlak; Shu G Chen; Jack C. de la Torre; George Perry; Gjumrakch Aliev
Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions.
Neurotoxicity research 2006;10(1):43-56.
2006: Sonia Franco; Maria A Blasco; Sandra L Siedlak; Peggy L R Harris; Paula I Moreira; George Perry; Mark A. Smith
Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(3):164-8.
2006: Xiongwei Zhu; Asim Babar; Sandra L Siedlak; Qiwei Yang; Genta Ito; Takeshi Iwatsubo; Mark A. Smith; George Perry; Shu G Chen
LRRK2 in Parkinson's disease and dementia with Lewy bodies.
Molecular neurodegeneration 2006;1():17.
2006: Paula I Moreira; Xiongwei Zhu; Quan Liu; Kazuhiro Honda; Sandra L Siedlak; Peggy L R Harris; Mark A. Smith; George Perry
Compensatory responses induced by oxidative stress in Alzheimer disease.
Biological research 2006;39(1):7-13.
2005: Rudy J Castellani; Sandra L Siedlak; Anne E Fortino; George Perry; Bernardino Ghetti; Mark A. Smith
Chitin-like polysaccharides in Alzheimer's disease brains.
Current Alzheimer research 2005;2(4):419-23.
2005: Robert B Petersen; Sandra L Siedlak; Hyoung-gon Lee; Yong-Sun Kim; Akihiko Nunomura; Fabrizio Tagliavini; Bernardino Ghetti; Patrick Cras; Paula I Moreira; Rudy J Castellani; Marin Guentchev; Herbert Budka; James W Ironside; Pierluigi Gambetti; Mark A. Smith; George Perry
Redox metals and oxidative abnormalities in human prion diseases.
Acta neuropathologica 2005;110(3):232-8.
2005: Paula I Moreira; Sandra L Siedlak; Gjumrakch Aliev; Xiongwei Zhu; Adam D Cash; Mark A. Smith; George Perry
Oxidative stress mechanisms and potential therapeutics in Alzheimer disease.
Journal of neural transmission (Vienna, Austria : 1996) 2005;112(7):921-32.
2005: Kazuhiro Honda; Mark A. Smith; Xiongwei Zhu; Diane Baus; William C Merrick; Alan M Tartakoff; Thomas Hattier; Peggy L R Harris; Sandra L Siedlak; Hisashi Fujioka; Quan Liu; Paula I Moreira; Frank P Miller; Akihiko Nunomura; Shun Shimohama; George Perry
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
The Journal of biological chemistry 2005;280(22):20978-86.
2005: Quan Liu; Mark A. Smith; Jesús Avila; John DeBernardis; Mayank M Kansal; Atsushi Takeda; Xiongwei Zhu; Akihiko Nunomura; Kazuhiro Honda; Paula I Moreira; Catarina R Oliveira; Maria S Santos; Shun Shimohama; Gjumrakch Aliev; Jack C. de la Torre; Hossein A Ghanbari; Sandra L Siedlak; Peggy L R Harris; Lawrence M Sayre; George Perry
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free radical biology & medicine 2005;38(6):746-54.
2005: Quan Liu; Hyoung-gon Lee; Kazuhiro Honda; Sandra L Siedlak; Peggy L R Harris; Adam D Cash; Xiongwei Zhu; Jesús Avila; Akihiko Nunomura; Atsushi Takeda; Mark A. Smith; George Perry
Tau modifiers as therapeutic targets for Alzheimer's disease.
Biochimica et biophysica acta 2005;1739(2-3):211-5.
2004: Quan Liu; F Xie; Sandra L Siedlak; Akihiko Nunomura; K Honda; Paula I Moreira; X Zhua; Mark A. Smith; George Perry
Neurofilament proteins in neurodegenerative diseases.
Cellular and molecular life sciences : CMLS 2004;61(24):3057-75.
2004: Xiongwei Zhu; Yang Wang; Osamu Ogawa; Hyoung-gon Lee; Arun K Raina; Sandra L Siedlak; Peggy L R Harris; Hisashi Fujioka; Shun Shimohama; Massimo Tabaton; Craig S Atwood; Robert B Petersen; George Perry; Mark A. Smith
Neuroprotective properties of Bcl-w in Alzheimer disease.
Journal of neurochemistry 2004;89(5):1233-40.
2004: Antonella Vitali; Alessandra Piccini; Roberta Borghi; Pantaleo Fornaro; Sandra L Siedlak; Mark A. Smith; Pierluigi Gambetti; Bernardino Ghetti; Massimo Tabaton
Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.
Journal of Alzheimer's disease : JAD 2004;6(1):45-51.
2003: George Perry; Akihiko Nunomura; Arun K Raina; Gjumrakch Aliev; Sandra L Siedlak; Peggy L R Harris; Gemma Casadesus Smith; Robert B Petersen; William Bligh-Glover; Elizabeth Balraj; Grace J Petot; Mark A. Smith
A metabolic basis for Alzheimer disease.
Neurochemical research 2003;28(10):1549-52.
2003: Gjumrakch Aliev; Dilara Seyidova; Bruce Lamb; Mark E Obrenovich; Sandra L Siedlak; Harry V Vinters; Robert P Friedland; Joseph C LaManna; Mark A. Smith; George Perry
Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice.
Neurological research 2003;25(6):665-74.
2003: Xiongwei Zhu; Zheng Sun; Hyoung-gon Lee; Sandra L Siedlak; George Perry; Mark A. Smith
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Journal of neurochemistry 2003;86(1):136-42.
2003: Adam D Cash; Gjumrakch Aliev; Sandra L Siedlak; Akihiko Nunomura; Hisashi Fujioka; Xiongwei Zhu; Arun K Raina; Harry V Vinters; Massimo Tabaton; Anne B Johnson; Manuel M Paula-Barbosa; Jesus Avíla; Paul K Jones; Rudy J Castellani; Mark A. Smith; George Perry
Microtubule reduction in Alzheimer's disease and aging is independent of tau filament formation.
The American journal of pathology 2003;162(5):1623-7.
2003: Jian Dong; Craig S Atwood; Vernon E Anderson; Sandra L Siedlak; Mark A. Smith; George Perry; Paul R Carey
Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence.
Biochemistry 2003;42(10):2768-73.
2003: George Perry; Marta A Taddeo; Robert B Petersen; Rudy J Castellani; Peggy L R Harris; Sandra L Siedlak; Adam D Cash; Quan Liu; Akihiko Nunomura; Craig S Atwood; Mark A. Smith
Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2003;16(1):77-81.
2002: Gjumrakch Aliev; Dilara Seyidova; Maxwell Neal; Jiong Shi; Bruce Lamb; Sandra L Siedlak; Harry V Vinters; Elizabeth Head; George Perry; Joseph C LaManna; Robert P Friedland; Carl W Cotman
Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice.
Annals of the New York Academy of Sciences 2002;977():45-64.
2002: Anthony W Hartzler; Xiongwei Zhu; Sandra L Siedlak; Rudy J Castellani; Jesús Avila; George Perry; Mark A. Smith
The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.
Neurobiology of aging 2002;23(5):855-9.
2002: Jiong Shi; George Perry; Marc S Berridge; Gjumrakch Aliev; Sandra L Siedlak; Mark A. Smith; Joseph C LaManna; Robert P Friedland
Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(8):1044-51.
2002: Marin Guentchev; Sandra L Siedlak; Christa Jarius; Fabrizio Tagliavini; Rudy J Castellani; George Perry; Mark A. Smith; Herbert Budka
Oxidative damage to nucleic acids in human prion disease.
Neurobiology of disease 2002;9(3):275-81.
2002: Takafumi Wataya; Akihiko Nunomura; Mark A. Smith; Sandra L Siedlak; Peggy L R Harris; Shun Shimohama; Luke I Szweda; Matthew A Kaminski; Jesús Avila; Donald L Price; Don W Cleveland; Lawrence M Sayre; George Perry
High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal.
The Journal of biological chemistry 2002;277(7):4644-8.
2002: Rudy J Castellani; George Perry; Sandra L Siedlak; Akihiko Nunomura; Shun Shimohama; Jing Zhang; Thomas J Montine; Lawrence M Sayre; Mark A. Smith
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans.
Neuroscience letters 2002;319(1):25-8.
2001: Keisuke Hirai; Gjumrakch Aliev; Akihiko Nunomura; Hisashi Fujioka; RL Russell; Craig S Atwood; A B Johnson; Y Kress; Harry V Vinters; Massimo Tabaton; Shun Shimohama; Adam D Cash; Sandra L Siedlak; Peggy L R Harris; Paul K Jones; Robert B Petersen; George Perry; Mark A. Smith
Mitochondrial abnormalities in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(9):3017-23.
2001: Arun K Raina; A Hochman; Xiongwei Zhu; Catherine A Rottkamp; Akihiko Nunomura; Sandra L Siedlak; H Boux; Rudy J Castellani; George Perry; Mark A. Smith
Abortive apoptosis in Alzheimer's disease.
Acta neuropathologica 2001;101(4):305-10.
2000: Atsushi Takeda; Mark A. Smith; Jesús Avila; Akihiko Nunomura; Sandra L Siedlak; Xiongwei Zhu; George Perry; Lawrence M Sayre
In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.
Journal of neurochemistry 2000;75(3):1234-41.
2000: Rudy J Castellani; Sandra L Siedlak; George Perry; Mark A. Smith
Sequestration of iron by Lewy bodies in Parkinson's disease.
Acta neuropathologica 2000;100(2):111-4.
2000: Patrizio Odetti; Silvano Garibaldi; R Norese; G Angelini; Lucio Marinelli; Sabina Valentini; Stefano Menini; Nicola Traverso; Damiano Zaccheo; Sandra L Siedlak; George Perry; Mark A. Smith; Massimo Tabaton
Lipoperoxidation is selectively involved in progressive supranuclear palsy.
Journal of neuropathology and experimental neurology 2000;59(5):393-7.
2000: JL Gerst; Arun K Raina; I Pirim; Andy McShea; Peggy L R Harris; Sandra L Siedlak; Atsushi Takeda; Robert B Petersen; Mark A. Smith
Altered cell-matrix associated ADAM proteins in Alzheimer disease.
Journal of neuroscience research 2000;59(5):680-4.
2000: H T Kim; RL Russell; Arun K Raina; Peggy L R Harris; Sandra L Siedlak; Xiongwei Zhu; Robert B Petersen; Shun Shimohama; Mark A. Smith; George Perry
Protein disulfide isomerase in Alzheimer disease.
Antioxidants & redox signaling 2000;2(3):485-9.
1999: RL Russell; Sandra L Siedlak; Arun K Raina; J M Bautista; Mark A. Smith; George Perry
Increased neuronal glucose-6-phosphate dehydrogenase and sulfhydryl levels indicate reductive compensation to oxidative stress in Alzheimer disease.
Archives of biochemistry and biophysics 1999;370(2):236-9.
1999: George Perry; H Roder; Akihiko Nunomura; Atsushi Takeda; Avi Friedlich; Xiongwei Zhu; Arun K Raina; N Holbrook; Sandra L Siedlak; P L Harris; Mark A. Smith
Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.
Neuroreport 1999;10(11):2411-5.
1999: JL Gerst; Sandra L Siedlak; Akihiko Nunomura; Rudy J Castellani; George Perry; Mark A. Smith
Role of oxidative stress in frontotemporal dementia.
Dementia and geriatric cognitive disorders 1999;10 Suppl 1():85-7.
1998: M E Velasco; Mark A. Smith; Sandra L Siedlak; Akihiko Nunomura; George Perry
Striation is the characteristic neuritic abnormality in Alzheimer disease.
Brain research 1998;813(2):329-33.
1998: Mark A. Smith; K Hirai; K Hsiao; Miguel Pappolla; Peggy L R Harris; Sandra L Siedlak; Massimo Tabaton; George Perry
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
Journal of neurochemistry 1998;70(5):2212-5.
1998: George Perry; Mark A. Smith; C E McCann; Sandra L Siedlak; Paul K Jones; Robert P Friedland
Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.
Brain research 1998;791(1-2):63-6.
1998: Mark A. Smith; K Wehr; Peggy L R Harris; Sandra L Siedlak; James Connor; George Perry
Abnormal localization of iron regulatory protein in Alzheimer's disease.
Brain research 1998;788(1-2):232-6.
1996: Mark A. Smith; Sandra L Siedlak; P L Richey; Ram H Nagaraj; A Elhammer; George Perry
Quantitative solubilization and analysis of insoluble paired helical filaments from Alzheimer disease.
Brain research 1996;717(1-2):99-108.
1996: S M Ali; Sandra L Siedlak; P A Gonzalez-DeWhitt; R A Altman; J M Glendening; D E Lowery; Mary J Savage; H G Polites; George Perry; Barry D Greenberg
Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice.
Neurobiology of aging 1996;17(2):223-34.
1996: Barry D Greenberg; Mary J Savage; D S Howland; S M Ali; Sandra L Siedlak; George Perry; R Siman; Richard W Scott
APP transgenesis: approaches toward the development of animal models for Alzheimer disease neuropathology.
Neurobiology of aging 1996;17(2):153-71.
1995: Mark A. Smith; Sandra L Siedlak; P L Richey; P Mulvihill; Jorge Ghiso; Blas Frangione; F Tagliavini; G Giaccone; O Bugiani; D Praprotnik
Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease.
Nature medicine 1995;1(4):365-9.
1995: P L Richey; Sandra L Siedlak; Mark A. Smith; George Perry
Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer disease: implications for disease pathogenesis.
Biochemical and biophysical research communications 1995;208(2):657-63.
1995: P Cras; Mark A. Smith; P L Richey; Sandra L Siedlak; P Mulvihill; George Perry
Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease.
Acta neuropathologica 1995;89(4):291-5.
1993: George Perry; P L Richey; Sandra L Siedlak; Mark A. Smith; P Mulvihill; D A DeWitt; J Barnett; Barry D Greenberg; Rajesh N. Kalaria
Immunocytochemical evidence that the beta-protein precursor is an integral component of neurofibrillary tangles of Alzheimer's disease.
The American journal of pathology 1993;143(6):1586-93.
1993: M Kawai; Rajesh N. Kalaria; P Cras; Sandra L Siedlak; M E Velasco; Earl R Shelton; H W Chan; Barry D Greenberg; George Perry
Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease.
Brain research 1993;623(1):142-6.
1992: George Perry; P Richey; Sandra L Siedlak; P Galloway; M Kawai; P Cras
Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases.
Brain research 1992;579(2):350-2.
1992: George Perry; P Cras; Sandra L Siedlak; Massimo Tabaton; M Kawai
Beta protein immunoreactivity is found in the majority of neurofibrillary tangles of Alzheimer's disease.
The American journal of pathology 1992;140(2):283-90.
1991: George Perry; Sandra L Siedlak; P Richey; M Kawai; P Cras; Rajesh N. Kalaria; P G Galloway; J M Scardina; Barbara Cordell; Barry D Greenberg
Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(11):3679-83.
1991: J Vande Weghe; P Cras; M Kawai; Sandra L Siedlak; Massimo Tabaton; Barry D Greenberg; George Perry
Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease.
Brain research 1991;560(1-2):303-5.
1991: P Cras; M Kawai; Sandra L Siedlak; George Perry
Microglia are associated with the extracellular neurofibrillary tangles of Alzheimer disease.
Brain research 1991;558(2):312-4.
1991: Sandra L Siedlak; P Cras; M Kawai; P Richey; George Perry
Basic fibroblast growth factor binding is a marker for extracellular neurofibrillary tangles in Alzheimer disease.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1991;39(7):899-904.
1990: P G Galloway; P Mulvihill; Sandra L Siedlak; M Mijares; M Kawai; H Padget; R Kim; George Perry
Immunochemical demonstration of tropomyosin in the neurofibrillary pathology of Alzheimer's disease.
The American journal of pathology 1990;137(2):291-300.
1990: P Cras; M Kawai; Sandra L Siedlak; P Mulvihill; Pierluigi Gambetti; D Lowery; P Gonzalez-DeWhitt; Barry D Greenberg; George Perry
Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.
The American journal of pathology 1990;137(2):241-6.
1989: M R Palmert; Sandra L Siedlak; Marcia B Podlisny; Barry D Greenberg; Earl R Shelton; H W Chan; M Usiak; Dennis J Selkoe; George Perry; Steven G Younkin
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.
Biochemical and biophysical research communications 1989;165(1):182-8.
1989: George Perry; Sandra L Siedlak; P Mulvihill; M Kancherla; M Mijares; M Kawai; Pierluigi Gambetti; S Sharma; L Maggiora; J Cornette
Immunolocalization of the amyloid precursor protein within the senile plaque.
Progress in clinical and biological research 1989;317():1021-5.