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Sandra Siepka

Research Profile

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Circadian Rhythm

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Seung-Hee Yoo; Ming Xu; Zheng Chen; Zhijian J Chen; Carla B Green; Hee-Kyung Hong; Seong Kwon Huh; Nobuya Koike; Izabela Kornblum; Vivek Kumar; Xinran Liu; Jennifer A Mohawk; Justin Nussbaum; Yongli Shan; Sandra M Siepka; Joseph S Takahashi
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Deborah Fenner; Joseph Grimsby; Hee-Kyung Hong; Yumiko Kobayashi; Akira Kohsaka; Franz M Matschinsky; Stella Odili; Sandra M Siepka; Joseph S Takahashi; Martha Hotz Vitaterna; Bogumil Zelent; Pan Chen; Joseph Bass
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
David F Clayton; Julia M George; Claudio V Mello; Sandra M Siepka
Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system.

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All Publications

2013: Seung-Hee Yoo; Ming Xu; Zheng Chen; Zhijian J Chen; Carla B Green; Hee-Kyung Hong; Seong Kwon Huh; Nobuya Koike; Izabela Kornblum; Vivek Kumar; Xinran Liu; Jennifer A Mohawk; Justin Nussbaum; Yongli Shan; Sandra M Siepka; Joseph S Takahashi
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Cell 2013;152(5):1091-105.
2011: Deborah Fenner; Joseph Grimsby; Hee-Kyung Hong; Yumiko Kobayashi; Akira Kohsaka; Franz M Matschinsky; Stella Odili; Sandra M Siepka; Joseph S Takahashi; Martha Hotz Vitaterna; Bogumil Zelent; Pan Chen; Joseph Bass
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
The Journal of biological chemistry 2011;286(45):39560-72.
2009: David F Clayton; Julia M George; Claudio V Mello; Sandra M Siepka
Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system.
Developmental neurobiology 2009;69(2-3):124-40.
2008: Lawrence H Pinto; Emily Eaton; Bohao Chen; Jonah Fleisher; Dmitry Shuster; Joel McCauley; Dalius Kedainis; Sandra M Siepka; Kazuhiro Shimomura; Eun-joo Song; Aliya Husain; Oren J Lakser; Richard W Mitchell; Maria L Dowell; Melanie Brown; Blanca Camoretti-Mercado; Robert M Naclerio; Anne I Sperling; Stephen I Levin; Fred W Turek; Julian Solway
Gene-environment interactions in a mutant mouse kindred with native airway constrictor hyperresponsiveness.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(1):2-14.
2007: Sandra M Siepka; Seung-Hee Yoo; Junghea Park; Weimin Song; Vivek Kumar; Yinin Hu; Choogon Lee; Joseph S Takahashi
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.
Cell 2007;129(5):1011-23.
2007: Sandra M Siepka; Seung-Hee Yoo; J Park; Cheolju Lee; Joseph S Takahashi
Genetics and neurobiology of circadian clocks in mammals.
Cold Spring Harbor symposia on quantitative biology 2007;72():251-9.
2007: Lawrence H Pinto; Martha Hotz Vitaterna; Kazuhiro Shimomura; Sandra M Siepka; Victoria Balannik; Erin L McDearmon; Chiaki Omura; Stephen Lumayag; Brandon M Invergo; Brett Glawe; Donald R Cantrell; Samsoon Inayat; Marissa A Olvera; Kirstan A Vessey; Maureen A McCall; Dennis Maddox; Catherine W Morgans; Brandon Young; Mathew Pletcher; robert Mullins; John B Troy; Joseph S Takahashi
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.
Visual neuroscience 2007;24(1):111-23.
2006: Jennifer L Moran; Andrew D Bolton; Pamela V Tran; Alison Brown; Noelle D Dwyer; Danielle K Manning; Bryan Bjork; Cheng Li; Kate Montgomery; Sandra M Siepka; Martha Hotz Vitaterna; Joseph S Takahashi; Timothy Wiltshire; David J Kwiatkowski; Raju Kucherlapati; David Beier
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Genome research 2006;16(3):436-40.
2005: Lawrence H Pinto; Martha Hotz Vitaterna; Kazuhiro Shimomura; Sandra M Siepka; Erin L McDearmon; Deborah Fenner; Stephen Lumayag; Chiaki Omura; Anne W Andrews; Matthew Baker; Brandon M Invergo; Marissa A Olvera; Edward Heffron; robert Mullins; Val C Sheffield; Edwin M Stone; Joseph S Takahashi
Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse.
Visual neuroscience 2005;22(5):619-29.
2005: Sandra M Siepka; Joseph S Takahashi
Methods to record circadian rhythm wheel running activity in mice.
Methods in enzymology 2005;393():230-9.
2005: Sandra M Siepka; Joseph S Takahashi
Forward genetic screens to identify circadian rhythm mutants in mice.
Methods in enzymology 2005;393():219-29.
2004: Lawrence H Pinto; Martha Hotz Vitaterna; Sandra M Siepka; Kazuhiro Shimomura; Stephen Lumayag; Matthew Baker; Deborah Fenner; robert Mullins; Val C Sheffield; Edwin M Stone; Edward Heffron; Joseph S Takahashi
Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.
Vision research 2004;44(28):3335-45.
2004: Amander T Clark; Dan Goldowitz; Joseph S Takahashi; Martha Hotz Vitaterna; Sandra M Siepka; Luanne L Peters; Wayne N Frankel; George A Carlson; Janet Rossant; Joseph H Nadeau; Monica J Justice
Implementing large-scale ENU mutagenesis screens in North America.
Genetica 2004;122(1):51-64.
2004: Seung-Hee Yoo; Shin Yamazaki; Phillip L Lowrey; Kazuhiro Shimomura; Caroline Ko; Ethan D Buhr; Sandra M Siepka; Hee-Kyung Hong; Won Jun Oh; Ook Joon Yoo; Michael Menaker; Joseph S Takahashi
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5339-46.