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Michael Sierks

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Procedures

Atomic Force Microscopy

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Living Beings

Physiology

Site-Directed Mutagenesis

Phenomena

Catalysis

Disorders

Alzheimer Disease

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Network (preview)

Co-Publications
Name
14
Svensson, Birte
10
Emadi, Sharareh
6
Liu, Ruitian
6
Schulz, Philip
5
Lyubchenko, Yuri
5
Yuan, Bin
5
Zameer, Andleeb
4
Reilly, Peter
4
McAllister, Chad
4
Ford, Clark
3
Barkhordarian, Hedieh
3
Goud, Gaddam Narsa
3
Messer, Anne
3
Lindsey, Stuart
2
Park, Chan Beum

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Publications

TOP 3
Wang Min S; Boddapati Shanta; Sierks Michael R
Cyclodextrins promote protein aggregation posing risks for therapeutic applications.
Kasturirangan Srinath; Brune Dan; Sierks Michael
Promoting alpha-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments.
Yuan Bin; Sierks Michael R
Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells.

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All Publications

2009: Wang Min S; Boddapati Shanta; Sierks Michael R
Cyclodextrins promote protein aggregation posing risks for therapeutic applications.
Biochemical and biophysical research communications 2009;386(3):526-31.
2009: Kasturirangan Srinath; Brune Dan; Sierks Michael
Promoting alpha-secretase cleavage of beta-amyloid with engineered proteolytic antibody fragments.
Biotechnology progress 2009;25(4):1054-63.
2009: Yuan Bin; Sierks Michael R
Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells.
Neuroscience letters 2009;459(1):16-8.
2009: Emadi Sharareh; Kasturirangan Srinath; Wang Min S; Schulz Philip; Sierks Michael R
Detecting morphologically distinct oligomeric forms of alpha-synuclein.
The Journal of biological chemistry 2009;284(17):11048-58.
2009: Liu Qiang; Huang Yao; Xue Fenqin; Simard Alain; DeChon Jamie; Li Guohui; Zhang Jianliang; Lucero Linda; Wang Min; Sierks Michael; Hu Gang; Chang Yongchang; Lukas Ronald J; Wu Jie
A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(4):918-29.
2009: Wang Min S; Zameer Andleeb; Emadi Sharareh; Sierks Michael R
Characterizing antibody specificity to different protein morphologies by AFM.
Langmuir : the ACS journal of surfaces and colloids 2009;25(2):912-8.
2009: Kvam Erik; Nannenga Brent L; Wang Min S; Jia Zongjian; Sierks Michael R; Messer Anne
Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.
PloS one 2009;4(5):e5727.
2008: Zameer Andleeb; Kasturirangan Srinath; Emadi Sharareh; Nimmagadda Sridevi V; Sierks Michael R
Anti-oligomeric Abeta single-chain variable domain antibody blocks Abeta-induced toxicity against human neuroblastoma cells.
Journal of molecular biology 2008;384(4):917-28.
2008: Marcus Warren D; Wang Hongda; Lindsay Stuart M; Sierks Michael R
Characterization of an antibody scFv that recognizes fibrillar insulin and beta-amyloid using atomic force microscopy.
Nanomedicine : nanotechnology, biology, and medicine 2008;4(1):1-7.
2008: Nannenga Brent L; Zameer Andleeb; Sierks Michael R
Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and alpha-synuclein aggregates.
FEBS letters 2008;582(4):517-22.
2007: Shlyakhtenko Luda S; Yuan Bin; Emadi Sharareh; Lyubchenko Yuri L; Sierks Michael R
Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy.
Nanomedicine : nanotechnology, biology, and medicine 2007;3(3):192-7.
2007: Emadi Sharareh; Barkhordarian Hedieh; Wang Min S; Schulz Philip; Sierks Michael R
Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity.
Journal of molecular biology 2007;368(4):1132-44.
2006: Masson Jean-Francois; Battaglia Tina M; Cramer Jeff; Beaudoin Stephen; Sierks Michael; Booksh Karl S
Reduction of nonspecific protein binding on surface plasmon resonance biosensors.
Analytical and bioanalytical chemistry 2006;386(7-8):1951-9.
2006: Levites Yona; Smithson Lisa A; Price Robert W; Dakin Rachel S; Yuan Bin; Sierks Michael R; Kim Jungsu; McGowan Eileen; Reed Dana Kim; Rosenberry Terrone L; Das Pritam; Golde Todd E
Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2576-8.
2006: Barkhordarian Hedieh; Emadi Sharareh; Schulz Philip; Sierks Michael R
Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies.
Protein engineering, design & selection : PEDS 2006;19(11):497-502.
2006: Zameer Andleeb; Schulz Philip; Wang Min S; Sierks Michael R
Single chain Fv antibodies against the 25-35 Abeta fragment inhibit aggregation and toxicity of Abeta42.
Biochemistry 2006;45(38):11532-9.
2006: Marcus Warren D; Lindsay Stuart M; Sierks Michael R
Identification and repair of positive binding antibodies containing randomly generated amber codons from synthetic phage display libraries.
Biotechnology progress 2006;22(3):919-22.
2006: Marcus W D; Wang H; Lohr D; Sierks M R; Lindsay S M
Isolation of an scFv targeting BRG1 using phage display with characterization by AFM.
Biochemical and biophysical research communications 2006;342(4):1123-9.
2005: Battaglia Tina M; Masson Jean-Francois; Sierks Michael R; Beaudoin Stephen P; Rogers Joseph; Foster Kevin N; Holloway G Allen; Booksh Karl S
Quantification of cytokines involved in wound healing using surface plasmon resonance.
Analytical chemistry 2005;77(21):7016-23.
2005: Liu Ruitian; Barkhordarian Hedieh; Emadi Sharareh; Park Chan Beum; Sierks Michael R
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42.
Neurobiology of disease 2005;20(1):74-81.
2005: Kanapathipillai Mathumai; Lentzen Georg; Sierks Michael; Park Chan Beum
Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-amyloid.
FEBS letters 2005;579(21):4775-80.
2004: Zhou Chun; Emadi Sharareh; Sierks Michael R; Messer Anne
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1023-31.
2004: Liu Ruitian; McAllister Chad; Lyubchenko Yuri; Sierks Michael R
Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity.
Biochemistry 2004;43(31):9999-10007.
2004: Liu Ruitian; Yuan Bin; Emadi Sharareh; Zameer Andleeb; Schulz Philip; McAllister Chad; Lyubchenko Yuri; Goud Gaddam; Sierks Michael R
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.
Biochemistry 2004;43(22):6959-67.
2004: Emadi Sharareh; Liu Ruitian; Yuan Bin; Schulz Philip; McAllister Chad; Lyubchenko Yuri; Messer Anne; Sierks Michael R
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments.
Biochemistry 2004;43(10):2871-8.
2004: Liu Ruitian; McAllister Chad; Lyubchenko Yuri; Sierks Michael R
Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation.
Journal of neuroscience research 2004;75(2):162-71.
2003: Rangan Srinath Kasturi; Liu Ruitian; Brune Daniel; Planque Stephanie; Paul Sudhir; Sierks Michael R
Degradation of beta-amyloid by proteolytic antibody light chains.
Biochemistry 2003;42(48):14328-34.
2001: Ferreira G M; Ahuja S K; Sierks M R; Moreira A R
Pleomorphism of the marine bacterium Teredinobacter turnirae.
Letters in applied microbiology 2001;33(1):56-60.
2001: Goud G N; Artsaenko O; Bols M; Sierks M
Specific glycosidase activity isolated from a random phage display antibody library.
Biotechnology progress 2001;17(1):197-202.
2000: Sierks M R; Svensson B
Energetic and mechanistic studies of glucoamylase using molecular recognition of maltose OH groups coupled with site-directed mutagenesis.
Biochemistry 2000;39(29):8585-92.
1998: Wu H; Goud G N; Sierks M R
Artificial antibodies for affinity chromatography of homologous proteins: application to blood clotting proteins.
Biotechnology progress 1998;14(3):496-9.
1997: Natarajan S K; Sierks M R
Minimizing nonproductive substrate binding: a new look at glucoamylase subsite affinities.
Biochemistry 1997;36(48):14946-55.
1997: Sierks M R; Sico C; Zaw M
Solvent and viscosity effects on the rate-limiting product release step of glucoamylase during maltose hydrolysis.
Biotechnology progress 1997;13(5):601-8.
1996: Natarajan S K; Sierks M R
Identification of enzyme-substrate and enzyme-product complexes in the catalytic mechanism of glucoamylase from Aspergillus awamori.
Biochemistry 1996;35(48):15269-79.
1996: Natarajan S; Sierks M R
Functional and structural roles of the highly conserved Trp120 loop region of glucoamylase from Aspergillus awamori.
Biochemistry 1996;35(9):3050-8.
1996: Sierks M R; Svensson B
Catalytic mechanism of glucoamylase probed by mutagenesis in conjunction with hydrolysis of alpha-D-glucopyranosyl fluoride and maltooligosaccharides.
Biochemistry 1996;35(6):1865-71.
1996: Dong W; Jespersen T; Bols M; Skrydstrup T; Sierks M R
Evaluation of isofagomine and its derivatives as potent glycosidase inhibitors.
Biochemistry 1996;35(8):2788-95.
1994: Sierks M R; Svensson B
Protein engineering of the relative specificity of glucoamylase from Aspergillus awamori based on sequence similarities between starch-degrading enzymes.
Protein engineering 1994;7(12):1479-84.
1994: Frandsen T P; Dupont C; Lehmbeck J; Stoffer B; Sierks M R; Honzatko R B; Svensson B
Site-directed mutagenesis of the catalytic base glutamic acid 400 in glucoamylase from Aspergillus niger and of tyrosine 48 and glutamine 401, both hydrogen-bonded to the gamma-carboxylate group of glutamic acid 400.
Biochemistry 1994;33(46):13808-16.
1993: Jespersen H M; MacGregor E A; Henrissat B; Sierks M R; Svensson B
Starch- and glycogen-debranching and branching enzymes: prediction of structural features of the catalytic (beta/alpha)8-barrel domain and evolutionary relationship to other amylolytic enzymes.
Journal of protein chemistry 1993;12(6):791-805.
1993: Olsen K; Christensen U; Sierks M R; Svensson B
Reaction mechanisms of Trp120-->Phe and wild-type glucoamylases from Aspergillus niger. Interactions with maltooligodextrins and acarbose.
Biochemistry 1993;32(37):9686-93.
1993: Sierks M R; Svensson B
Functional roles of the invariant aspartic acid 55, tyrosine 306, and aspartic acid 309 in glucoamylase from Aspergillus awamori studied by mutagenesis.
Biochemistry 1993;32(4):1113-7.
1993: Sierks M R; Ford C; Reilly P J; Svensson B
Functional roles and subsite locations of Leu177, Trp178 and Asn182 of Aspergillus awamori glucoamylase determined by site-directed mutagenesis.
Protein engineering 1993;6(1):75-9.
1992: Sierks M R; Bock K; Refn S; Svensson B
Active site similarities of glucose dehydrogenase, glucose oxidase, and glucoamylase probed by deoxygenated substrates.
Biochemistry 1992;31(37):8972-7.
1992: Svensson B; Sierks M R
Roles of the aromatic side chains in the binding of substrates, inhibitors, and cyclomalto-oligosaccharides to the glucoamylase from Aspergillus niger probed by perturbation difference spectroscopy, chemical modification, and mutagenesis.
Carbohydrate research 1992;227():29-44.
1992: Sierks M R; Svensson B
Kinetic identification of a hydrogen bonding pair in the glucoamylase-maltose transition state complex.
Protein engineering 1992;5(2):185-8.
1991: Jespersen H M; MacGregor E A; Sierks M R; Svensson B
Comparison of the domain-level organization of starch hydrolases and related enzymes.
The Biochemical journal 1991;280 ( Pt 1)():51-5.
1990: Evans R; Ford C; Sierks M; Nikolov Z; Svensson B
Activity and thermal stability of genetically truncated forms of Aspergillus glucoamylase.
Gene 1990;91(1):131-4.
1990: Sierks M R; Ford C; Reilly P J; Svensson B
Catalytic mechanism of fungal glucoamylase as defined by mutagenesis of Asp176, Glu179 and Glu180 in the enzyme from Aspergillus awamori.
Protein engineering 1990;3(3):193-8.
1989: Svensson B; Jespersen H; Sierks M R; MacGregor E A
Sequence homology between putative raw-starch binding domains from different starch-degrading enzymes.
The Biochemical journal 1989;264(1):309-11.
1989: Sierks M R; Ford C; Reilly P J; Svensson B
Site-directed mutagenesis at the active site Trp120 of Aspergillus awamori glucoamylase.
Protein engineering 1989;2(8):621-5.
1985: Sierks M R; Reilly P J
Application of cross-linked carboxymethyl cellulose degradation by beta-glucosidase and vaginal microbes to toxic shock syndrome.
Applied and environmental microbiology 1985;50(3):634-7.

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