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Helmut Sies

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

Living Beings

Rats

Phenomena

Anatomy

Disorders

Oxidative Stress

Physiology

Lipid Peroxidation

Procedures

High Pressure Liquid Chromatography

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Co-Publications
Name
80
Stahl, Wilhelm
46
Klotz, Lars-Oliver
20
Briviba, K
19
Schewe, Tankred
18
Brenneisen, Peter
16
Steinbrenner, Holger
16
Schulz, Wolfgang
12
Polidori, Cristina
11
Stuhlmann, Dominik
10
Tronnier, Hagen
10
Heinrich, Ulrike
9
Arteel, GE
8
Buchczyk, Darius
8
Devasagayam, Thomas
8
Ruzicka, Thomas

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Publications

TOP 3
Sies Helmut
Highlight: molecular and cellular mechanisms of memory.
Ale-Agha Niloofar; Galban Stefanie; Sobieroy Christiane; Abdelmohsen Kotb; Gorospe Myriam; Sies Helmut; Klotz Lars-Oliver
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.
Steinbrenner Holger; Sies Helmut
Protection against reactive oxygen species by selenoproteins.

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All Publications

2009: Sies Helmut
Highlight: molecular and cellular mechanisms of memory.
Biological chemistry 2009;390(11):1085.
2009: Ale-Agha Niloofar; Galban Stefanie; Sobieroy Christiane; Abdelmohsen Kotb; Gorospe Myriam; Sies Helmut; Klotz Lars-Oliver
HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity.
Hepatology (Baltimore, Md.) 2009;50(5):1567-76.
2009: Steinbrenner Holger; Sies Helmut
Protection against reactive oxygen species by selenoproteins.
Biochimica et biophysica acta 2009;1790(11):1478-85.
2009: Häussinger Dieter; Sies Helmut
Highlight: 'regenerative hepatology'.
Biological chemistry 2009;390(10):949-50.
2009: Speckmann Bodo; Sies Helmut; Steinbrenner Holger
Attenuation of hepatic expression and secretion of selenoprotein P by metformin.
Biochemical and biophysical research communications 2009;387(1):158-63.
2009: Camera Emanuela; Mastrofrancesco Arianna; Fabbri Claudia; Daubrawa Felicitas; Picardo Mauro; Sies Helmut; Stahl Wilhelm
Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes.
Experimental dermatology 2009;18(3):222-31.
2009: De Spirt Silke; Stahl Wilhelm; Tronnier Hagen; Sies Helmut; Bejot Marie; Maurette Jean-Marc; Heinrich Ulrike
Intervention with flaxseed and borage oil supplements modulates skin condition in women.
The British journal of nutrition 2009;101(3):440-5.
2009: Polidori Maria Cristina; Carrillo Juan-Carlos; Verde Pablo E; Sies Helmut; Siegrist Johannes; Stahl Wilhelm
Plasma micronutrient status is improved after a 3-month dietary intervention with 5 daily portions of fruits and vegetables: implications for optimal antioxidant levels.
Nutrition journal 2009;8():10.
2008: Speckmann Bodo; Walter Philippe L; Alili Lirija; Reinehr Roland; Sies Helmut; Klotz Lars-Oliver; Steinbrenner Holger
Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors.
Hepatology (Baltimore, Md.) 2008;48(6):1998-2006.
2008: Schewe Tankred; Steffen Yvonne; Sies Helmut
How do dietary flavanols improve vascular function? A position paper.
Archives of biochemistry and biophysics 2008;476(2):102-6.
2008: Schnorr Oliver; Brossette Tatjana; Momma Tony Y; Kleinbongard Petra; Keen Carl L; Schroeter Hagen; Sies Helmut
Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo.
Archives of biochemistry and biophysics 2008;476(2):211-5.
2008: Spalteholz Holger; Furtmüller Paul Georg; Jakopitsch Christa; Obinger Christian; Schewe Tankred; Sies Helmut; Arnhold Jürgen
Kinetic evidence for rapid oxidation of (-)-epicatechin by human myeloperoxidase.
Biochemical and biophysical research communications 2008;371(4):810-3.
2008: Pirev Elvis; Calles Christian; Schroeder Peter; Sies Helmut; Kröncke Klaus-D
Ultraviolet-A irradiation but not ultraviolet-B or infrared-A irradiation leads to a disturbed zinc homeostasis in cells.
Free radical biology & medicine 2008;45(1):86-91.
2008: Werth Christel; Stuhlmann Dominik; Cat Bahar; Steinbrenner Holger; Alili Lirija; Sies Helmut; Brenneisen Peter
Stromal resistance of fibroblasts against oxidative damage: involvement of tumor cell-secreted platelet-derived growth factor (PDGF) and phosphoinositide 3-kinase (PI3K) activation.
Carcinogenesis 2008;29(2):404-10.
2008: Bellei Barbara; Mastrofrancesco Arianna; Briganti Stefania; Aspite Nicaela; Ale-Agha Niloofar; Sies Helmut; Picardo Mauro
Ultraviolet A induced modulation of gap junctional intercellular communication by P38 MAPK activation in human keratinocytes.
Experimental dermatology 2008;17(2):115-24.
2008: Steffen Yvonne; Gruber Claudia; Schewe Tankred; Sies Helmut
Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase.
Archives of biochemistry and biophysics 2008;469(2):209-19.
2007: Abdelmohsen Kotb; Sauerbier Elisabeth; Ale-Agha Niloofar; Beier Juliane; Walter Philippe; Galban Stefanie; Stuhlmann Dominik; Sies Helmut; Klotz Lars-Oliver
Epidermal growth factor- and stress-induced loss of gap junctional communication is mediated by ERK-1/ERK-2 but not ERK-5 in rat liver epithelial cells.
Biochemical and biophysical research communications 2007;364(2):313-7.
2007: Steinbrenner Holger; Alili Lirija; Stuhlmann Dominik; Sies Helmut; Brenneisen Peter
Post-translational processing of selenoprotein P: implications of glycosylation for its utilisation by target cells.
Biological chemistry 2007;388(10):1043-51.
2007: Stahl Wilhelm; Sies Helmut
Carotenoids and flavonoids contribute to nutritional protection against skin damage from sunlight.
Molecular biotechnology 2007;37(1):26-30.
2007: Sies H
Biological redox systems and oxidative stress.
Cellular and molecular life sciences : CMLS 2007;64(17):2181-8.
2007: Waterman Michael R; Fitzpatrick Paul; Scarpa Toni; Sies Helmut
Highlight issue: enzymology of drug metabolism and toxicology.
Archives of biochemistry and biophysics 2007;464(2):153-4.
2007: Steffen Yvonne; Schewe Tankred; Sies Helmut
(-)-Epicatechin elevates nitric oxide in endothelial cells via inhibition of NADPH oxidase.
Biochemical and biophysical research communications 2007;359(3):828-33.
2007: Sies Helmut
How I became a biochemist.
IUBMB life 2007;59(7):469-73.
2007: Kagemann Guido; Sies Helmut; Schnorr Oliver
Limited availability of L-arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression.
Journal of molecular medicine (Berlin, Germany) 2007;85(7):723-32.
2007: Sies Helmut
Total antioxidant capacity: appraisal of a concept.
The Journal of nutrition 2007;137(6):1493-5.
2007: Polidori M Cristina; Praticó Domenico; Parente Basso; Mariani Elena; Cecchetti Roberta; Yao Yuemang; Sies Helmut; Cao Piergiorgio; Mecocci Patrizia; Stahl Wilhelm
Elevated lipid peroxidation biomarkers and low antioxidant status in atherosclerotic patients with increased carotid or iliofemoral intima media thickness.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2007;55(4):163-7.
2007: Peterson Lisa A; Wagener Tanja; Sies Helmut; Stahl Wilhelm
Decomposition of S-nitrosocysteine via S- to N-transnitrosation.
Chemical research in toxicology 2007;20(5):721-3.
2007: Steffen Yvonne; Jung Tobias; Klotz Lars-Oliver; Schewe Tankred; Grune Tilman; Sies Helmut
Protein modification elicited by oxidized low-density lipoprotein (LDL) in endothelial cells: protection by (-)-epicatechin.
Free radical biology & medicine 2007;42(7):955-70.
2007: Heiss Christian; Finis David; Kleinbongard Petra; Hoffmann Arne; Rassaf Tienush; Kelm Malte; Sies Helmut
Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week.
Journal of cardiovascular pharmacology 2007;49(2):74-80.
2007: Neukam Karin; Stahl Wilhelm; Tronnier Hagen; Sies Helmut; Heinrich Ulrike
Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin.
European journal of nutrition 2007;46(1):53-6.
2006: Nesaretnam Kalanithi; Sies Helmut
6th COSTAM/SFRR (ASEAN/Malaysia) International Workshop on Micronutrients, Oxidative Stress, and the Environment.
Antioxidants & redox signaling 2006;8(11-12):2175-7.
2006: von Montfort Claudia; Fernau Niklas S; Beier Juliane I; Sies Helmut; Klotz Lars-Oliver
Extracellular generation of hydrogen peroxide is responsible for activation of EGF receptor by ultraviolet A radiation.
Free radical biology & medicine 2006;41(9):1478-87.
2006: von Montfort Claudia; Sharov Victor S; Metzger Sabine; Schöneich Christian; Sies Helmut; Klotz Lars-Oliver
Singlet oxygen inactivates protein tyrosine phosphatase-1B by oxidation of the active site cysteine.
Biological chemistry 2006;387(10-11):1399-404.
2006: Steffen Yvonne; Schewe Tankred; Sies Helmut
Myeloperoxidase-mediated LDL oxidation and endothelial cell toxicity of oxidized LDL: attenuation by (-)-epicatechin.
Free radical research 2006;40(10):1076-85.
2006: Engers Rainer; Springer Erik; Kehren Verena; Simic Tatjana; Young David A; Beier Juliane; Klotz Lars-O; Clark Ian M; Sies Helmut; Gabbert Helmut E
Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.
The FEBS journal 2006;273(20):4754-69.
2006: Walter Philippe L; Kampkötter Andreas; Eckers Anna; Barthel Andreas; Schmoll Dieter; Sies Helmut; Klotz Lars-Oliver
Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions.
Archives of biochemistry and biophysics 2006;454(2):107-13.
2006: Steffen Yvonne; Wiswedel Ingrid; Peter Daniela; Schewe Tankred; Sies Helmut
Cytotoxicity of myeloperoxidase/nitrite-oxidized low-density lipoprotein toward endothelial cells is due to a high 7beta-hydroxycholesterol to 7-ketocholesterol ratio.
Free radical biology & medicine 2006;41(7):1139-50.
2006: Steinbrenner Holger; Bilgic Esra; Alili Lirija; Sies Helmut; Brenneisen Peter
Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity.
Free radical research 2006;40(9):936-43.
2006: Cat Bahar; Stuhlmann Dominik; Steinbrenner Holger; Alili Lirija; Holtkötter Olaf; Sies Helmut; Brenneisen Peter
Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.
Journal of cell science 2006;119(Pt 13):2727-38.
2006: Heinrich Ulrike; Neukam Karin; Tronnier Hagen; Sies Helmut; Stahl Wilhelm
Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women.
The Journal of nutrition 2006;136(6):1565-9.
2006: Suschek Christoph V; Schewe Tankred; Sies Helmut; Kröncke Klaus-Dietrich
Nitrite, a naturally occurring precursor of nitric oxide that acts like a 'prodrug'.
Biological chemistry 2006;387(5):499-506.
2006: Steinbrenner Holger; Alili Lirija; Bilgic Esra; Sies Helmut; Brenneisen Peter
Involvement of selenoprotein P in protection of human astrocytes from oxidative damage.
Free radical biology & medicine 2006;40(9):1513-23.
2006: Kuhn Michaela; Wolber Rainer; Kolbe Ludger; Schnorr Oliver; Sies Helmut
Solar-simulated radiation induces secretion of IL-6 and production of isoprostanes in human skin in vivo.
Archives of dermatological research 2006;297(10):477-9.
2006: Beier Juliane I; von Montfort Claudia; Sies Helmut; Klotz Lars-Oliver
Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: role of EGFR and protein tyrosine phosphatases.
FEBS letters 2006;580(7):1859-64.
2006: Stahl Wilhelm; Heinrich Ulrike; Aust Olivier; Tronnier Hagen; Sies Helmut
Lycopene-rich products and dietary photoprotection.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2006;5(2):238-42.
2006: Schroeter Hagen; Heiss Christian; Balzer Jan; Kleinbongard Petra; Keen Carl L; Hollenberg Norman K; Sies Helmut; Kwik-Uribe Catherine; Schmitz Harold H; Kelm Malte
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):1024-9.
2006: Heiss Christian; Schroeter Hagen; Balzer Jan; Kleinbongard Petra; Matern Simone; Sies Helmut; Kelm Malte
Endothelial function, nitric oxide, and cocoa flavanols.
Journal of cardiovascular pharmacology 2006;47 Suppl 2():S128-35; discussion S172-6.
2005: Anlasik Timur; Sies Helmut; Griffiths Helen R; Mecocci Patrizia; Stahl Wilhelm; Polidori M Cristina
Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects.
The British journal of nutrition 2005;94(5):639-42.
2005: Daubrawa Felicitas; Sies Helmut; Stahl Wilhelm
Astaxanthin diminishes gap junctional intercellular communication in primary human fibroblasts.
The Journal of nutrition 2005;135(11):2507-11.
2005: Heiss Christian; Kleinbongard Petra; Dejam Andrè; Perré Sandra; Schroeter Hagen; Sies Helmut; Kelm Malte
Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers.
Journal of the American College of Cardiology 2005;46(7):1276-83.
2005: Schuier Maximilian; Sies Helmut; Illek Beate; Fischer Horst
Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia.
The Journal of nutrition 2005;135(10):2320-5.
2005: Kálai Tamas; Mugesh Govindasamy; Roy Gouriprasanna; Sies Helmut; Berente Zoltán; Hideg Kálmán
Combining benzo[d]isoselenazol-3-ones with sterically hindered alicyclic amines and nitroxides: enhanced activity as glutathione peroxidase mimics.
Organic & biomolecular chemistry 2005;3(19):3564-9.
2005: Brenneisen Peter; Steinbrenner Holger; Sies Helmut
Selenium, oxidative stress, and health aspects.
Molecular aspects of medicine 2005;26(4-5):256-67.
2005: Steffen Yvonne; Schewe Tankred; Sies Helmut
Epicatechin protects endothelial cells against oxidized LDL and maintains NO synthase.
Biochemical and biophysical research communications 2005;331(4):1277-83.
2005: Stahl Wilhelm; Sies Helmut
Bioactivity and protective effects of natural carotenoids.
Biochimica et biophysica acta 2005;1740(2):101-7.
2005: Sies Helmut; Stahl Wilhelm; Sevanian Alex
Nutritional, dietary and postprandial oxidative stress.
The Journal of nutrition 2005;135(5):969-72.
2005: Hathcock John N; Azzi Angelo; Blumberg Jeffrey; Bray Tammy; Dickinson Annette; Frei Balz; Jialal Ishwarlal; Johnston Carol S; Kelly Frank J; Kraemer Klaus; Packer Lester; Parthasarathy Sampath; Sies Helmut; Traber Maret G
Vitamins E and C are safe across a broad range of intakes.
The American journal of clinical nutrition 2005;81(4):736-45.
2005: Schnorr Oliver; Schuier Maximilian; Kagemann Guido; Wolf Ronald; Walz Markus; Ruzicka Thomas; Mayatepek Ertan; Laryea Maurice; Suschek Christoph V; Kolb-Bachofen Victoria; Sies Helmut
Arginase-1 overexpression induces cationic amino acid transporter-1 in psoriasis.
Free radical biology & medicine 2005;38(8):1073-9.
2005: Abdelmohsen Kotb; von Montfort Claudia; Stuhlmann Dominik; Gerber P Arne; Decking Ulrich K M; Sies Helmut; Klotz Lars-Oliver
Doxorubicin induces EGF receptor-dependent downregulation of gap junctional intercellular communication in rat liver epithelial cells.
Biological chemistry 2005;386(3):217-23.
2005: Steinbrenner Holger; Ramos Maria C; Stuhlmann Dominik; Mitic Dragana; Sies Helmut; Brenneisen Peter
Tumor promoter TPA stimulates MMP-9 secretion from human keratinocytes by activation of superoxide-producing NADPH oxidase.
Free radical research 2005;39(3):245-53.
2005: Melchheier Ira; von Montfort Claudia; Stuhlmann Dominik; Sies Helmut; Klotz Lars-Oliver
Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation.
Biochemical and biophysical research communications 2005;327(4):1016-23.
2005: Azzi Angelo; Brigelius-Flohé Regina; Kelly Frank; Lodge John K; Ozer Nesrin; Packer Lester; Sies Helmut
On the opinion of the European Commission "Scientific Committee on Food" regarding the tolerable upper intake level of vitamin E (2003).
European journal of nutrition 2005;44(1):60-2.
2005: Aust Olivier; Stahl Wilhelm; Sies Helmut; Tronnier Hagen; Heinrich Ulrike
Supplementation with tomato-based products increases lycopene, phytofluene, and phytoene levels in human serum and protects against UV-light-induced erythema.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2005;75(1):54-60.
2005: Sies Helmut; Schewe Tankred; Heiss Christian; Kelm Malte
Cocoa polyphenols and inflammatory mediators.
The American journal of clinical nutrition 2005;81(1 Suppl):304S-312S.
2005: Schroeder Peter; Voevodskaya Nina; Klotz Lars-Oliver; Brenneisen Peter; Gräslund Astrid; Sies Helmut
Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin.
Biochemical and biophysical research communications 2005;326(3):614-7.
2005: Polidori M Cristina; Praticó Domenico; Ingegni Tiziana; Mariani Elena; Spazzafumo Liana; Del Sindaco Paola; Cecchetti Roberta; Yao Yuemang; Ricci Stefano; Cherubini Antonio; Stahl Wilhelm; Sies Helmut; Senin Umberto; Mecocci Patrizia;
Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study.
BioFactors (Oxford, England) 2005;24(1-4):265-74.
2005: Schewe Tankred; Sies Helmut
Myeloperoxidase-induced lipid peroxidation of LDL in the presence of nitrite. Protection by cocoa flavanols.
BioFactors (Oxford, England) 2005;24(1-4):49-58.
2004: Packer Lester; Azzi Angelo; Kraemer Klaus; Ozer Nesrin; Sies Helmut; Niki Etsuo; Violi Francesco; Vatassery Govind
Future directions in preclinical vitamin E research: panel discussion A.
Annals of the New York Academy of Sciences 2004;1031():305-12.
2004: Kraemer Tilo; Prakosay Inthanongsack; Date Rahul A; Sies Helmut; Schewe Tankred
Oxidative modification of low-density lipoprotein: lipid peroxidation by myeloperoxidase in the presence of nitrite.
Biological chemistry 2004;385(9):809-18.
2004: Sies Helmut; Stahl Wilhelm
Carotenoids and UV protection.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004;3(8):749-52.
2004: Wiswedel Ingrid; Hirsch Daniela; Kropf Siegfried; Gruening Martin; Pfister Eberhard; Schewe Tankred; Sies Helmut
Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans.
Free radical biology & medicine 2004;37(3):411-21.
2004: Sies Helmut
Ozone in arteriosclerotic plaques: searching for the "smoking gun".
Angewandte Chemie (International ed. in English) 2004;43(27):3514-5.
2004: Stuhlmann Dominik; Steinbrenner Holger; Wendlandt Bernhard; Mitic Dragana; Sies Helmut; Brenneisen Peter
Paracrine effect of TGF-beta1 on downregulation of gap junctional intercellular communication between human dermal fibroblasts.
Biochemical and biophysical research communications 2004;319(2):321-6.
2004: Mahns André; Wolber Rainer; Stäb Franz; Klotz Lars-Oliver; Sies Helmut
Contribution of UVB and UVA to UV-dependent stimulation of cyclooxygenase-2 expression in artificial epidermis.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2004;3(3):257-62.
2004: Oh Jang-Hee; Chung An-Sik; Steinbrenner Holger; Sies Helmut; Brenneisen Peter
Thioredoxin secreted upon ultraviolet A irradiation modulates activities of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in human dermal fibroblasts.
Archives of biochemistry and biophysics 2004;423(1):218-26.
2004: Traulsen Henrik; Steinbrenner Holger; Buchczyk Darius P; Klotz Lars-Oliver; Sies Helmut
Selenoprotein P protects low-density lipoprotein against oxidation.
Free radical research 2004;38(2):123-8.
2004: Ramos Maria C; Steinbrenner Holger; Stuhlmann Dominik; Sies Helmut; Brenneisen Peter
Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation.
Biological chemistry 2004;385(1):75-86.
2004: Polidori M Cristina; Mattioli Paola; Aldred Sarah; Cecchetti Roberta; Stahl Wilhelm; Griffiths Helen; Senin Umberto; Sies Helmut; Mecocci Patrizia
Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia.
Dementia and geriatric cognitive disorders 2004;18(3-4):265-70.
2004: Sies Helmut; Stahl Wilhelm
Nutritional protection against skin damage from sunlight.
Annual review of nutrition 2004;24():173-200.
2004: Abdelmohsen Kotb; Patak Pauline; Von Montfort Claudia; Melchheier Ira; Sies Helmut; Klotz Lars-Oliver
Signaling effects of menadione: from tyrosine phosphatase inactivation to connexin phosphorylation.
Methods in enzymology 2004;378():258-72.
2003: Giles Gregory I; Fry Fiona H; Tasker Karen M; Holme Andrea L; Peers Chris; Green Kim N; Klotz Lars-Oliver; Sies Helmut; Jacob Claus
Evaluation of sulfur, selenium and tellurium catalysts with antioxidant potential.
Organic & biomolecular chemistry 2003;1(23):4317-22.
2003: Stahl Wilhelm; Sies Helmut
Antioxidant activity of carotenoids.
Molecular aspects of medicine 2003;24(6):345-51.
2003: Suschek Christoph V; Schroeder Peter; Aust Olivier; Sies Helmut; Mahotka Csaba; Horstjann Markus; Ganser Heiko; Mürtz Manfred; Hering Peter; Schnorr Oliver; Kröncke Klaus-Dietrich; Kolb-Bachofen Victoria
The presence of nitrite during UVA irradiation protects from apoptosis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2342-4.
2003: Stuhlmann Dominik; Ale-Agha Niloofar; Reinehr Roland; Steinbrenner Holger; Ramos Maria C; Sies Helmut; Brenneisen Peter
Modulation of homologous gap junctional intercellular communication of human dermal fibroblasts via a paracrine factor(s) generated by squamous tumor cells.
Carcinogenesis 2003;24(11):1737-48.
2003: Jacob Claus; Giles Gregory I; Giles Niroshini M; Sies Helmut
Sulfur and selenium: the role of oxidation state in protein structure and function.
Angewandte Chemie (International ed. in English) 2003;42(39):4742-58.
2003: Aust O; Ale-Agha N; Zhang L; Wollersen H; Sies H; Stahl W
Lycopene oxidation product enhances gap junctional communication.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(10):1399-407.
2003: Abdelmohsen Kotb; Gerber P Arne; von Montfort Claudia; Sies Helmut; Klotz Lars-Oliver
Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases.
The Journal of biological chemistry 2003;278(40):38360-7.
2003: Mugesh Govindasamy; Klotz Lars-Oliver; du Mont Wolf-Walther; Becker Katja; Sies Helmut
Selenenyl iodide: a new substrate for mammalian thioredoxin reductase.
Organic & biomolecular chemistry 2003;1(16):2848-52.
2003: Heiss Christian; Dejam André; Kleinbongard Petra; Schewe Tankred; Sies Helmut; Kelm Malte
Vascular effects of cocoa rich in flavan-3-ols.
JAMA : the journal of the American Medical Association 2003;290(8):1030-1.
2003: Steinbrenner Holger; Ramos Maria Cristina; Stuhlmann Dominik; Sies Helmut; Brenneisen Peter
UVA-mediated downregulation of MMP-2 and MMP-9 in human epidermal keratinocytes.
Biochemical and biophysical research communications 2003;308(3):486-91.
2003: Betancor-Fernández Alejandro; Pérez-Gálvez Antonio; Sies Helmut; Stahl Wilhelm
Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity.
The Journal of pharmacy and pharmacology 2003;55(7):981-6.
2003: Schroeder Peter; Klotz Lars-Oliver; Sies Helmut
Amphiphilic properties of (-)-epicatechin and their significance for protection of cells against peroxynitrite.
Biochemical and biophysical research communications 2003;307(1):69-73.
2003: Polidori M Cristina; Mecocci Patrizia; Stahl Wilhelm; Sies Helmut
Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge.
The British journal of nutrition 2003;90(1):147-50.
2003: Pérez-Gálvez Antonio; Martin Hans D; Sies Helmut; Stahl Wilhelm
Incorporation of carotenoids from paprika oleoresin into human chylomicrons.
The British journal of nutrition 2003;89(6):787-93.
2003: Suschek Christoph V; Schnorr Oliver; Hemmrich Karsten; Aust Olivier; Klotz Lars-Oliver; Sies Helmut; Kolb-Bachofen Victoria
Critical role of L-arginine in endothelial cell survival during oxidative stress.
Circulation 2003;107(20):2607-14.
2003: Klotz Lars-Oliver; Kröncke Klaus-Dietrich; Buchczyk Darius P; Sies Helmut
Role of copper, zinc, selenium and tellurium in the cellular defense against oxidative and nitrosative stress.
The Journal of nutrition 2003;133(5 Suppl 1):1448S-51S.
2003: Mahns André; Melchheier Ira; Suschek Christoph V; Sies Helmut; Klotz Lars-Oliver
Irradiation of cells with ultraviolet-A (320-400 nm) in the presence of cell culture medium elicits biological effects due to extracellular generation of hydrogen peroxide.
Free radical research 2003;37(4):391-7.
2003: Klotz Lars-Oliver; Sies Helmut
Defenses against peroxynitrite: selenocompounds and flavonoids.
Toxicology letters 2003;140-141():125-32.
2003: Sies Helmut; Stahl Wilhelm
Non-nutritive bioactive constituents of plants: lycopene, lutein and zeaxanthin.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 2003;73(2):95-100.
2003: Sadik Christian David; Sies Helmut; Schewe Tankred
Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action.
Biochemical pharmacology 2003;65(5):773-81.
2003: Buchczyk Darius P; Grune Tilman; Sies Helmut; Klotz Lars-Oliver
Modifications of glyceraldehyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome.
Biological chemistry 2003;384(2):237-41.
2003: Jösch Claudio; Klotz Lars-Oliver; Sies Helmut
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
Biological chemistry 2003;384(2):213-8.
2003: Klotz Lars-Oliver; Kröncke Klaus-Dietrich; Sies Helmut
Singlet oxygen-induced signaling effects in mammalian cells.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2003;2(2):88-94.
2003: Kostyuk Vladimir A; Kraemer Tilo; Sies Helmut; Schewe Tankred
Myeloperoxidase/nitrite-mediated lipid peroxidation of low-density lipoprotein as modulated by flavonoids.
FEBS letters 2003;537(1-3):146-50.
2003: Heinrich Ulrike; Gärtner Christine; Wiebusch Mathilde; Eichler Olaf; Sies Helmut; Tronnier Hagen; Stahl Wilhelm
Supplementation with beta-carotene or a similar amount of mixed carotenoids protects humans from UV-induced erythema.
The Journal of nutrition 2003;133(1):98-101.
2002: Schieke StefanM; Stege Helger; Kürten Viola; Grether-Beck Susanne; Sies Helmut; Krutmann Jean
Infrared-A radiation-induced matrix metalloproteinase 1 expression is mediated through extracellular signal-regulated kinase 1/2 activation in human dermal fibroblasts.
The Journal of investigative dermatology 2002;119(6):1323-9.
2002: Brenneisen Peter; Sies Helmut; Scharffetter-Kochanek Karin
Ultraviolet-B irradiation and matrix metalloproteinases: from induction via signaling to initial events.
Annals of the New York Academy of Sciences 2002;973():31-43.
2002: McKim Stephen E; Konno Akira; Gäbele Erwin; Uesugi Takehiko; Froh Mathias; Sies Helmut; Thurman Ronald G; Arteel Gavin E
Cocoa extract protects against early alcohol-induced liver injury in the rat.
Archives of biochemistry and biophysics 2002;406(1):40-6.
2002: Stahl Wilhelm; Sies Helmut
Carotenoids and protection against solar UV radiation.
Skin pharmacology and applied skin physiology 2002;15(5):291-6.
2002: Klotz Lars-Oliver; Patak Pauline; Ale-Agha Niloofar; Buchczyk Darius P; Abdelmohsen Kotb; Gerber P Arne; von Montfort Claudia; Sies Helmut
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade.
Cancer research 2002;62(17):4922-8.
2002: Klotz Lars-Oliver; Schroeder Peter; Sies Helmut
Peroxynitrite signaling: receptor tyrosine kinases and activation of stress-responsive pathways.
Free radical biology & medicine 2002;33(6):737-43.
2002: Betancor-Fernandez Alejandro; Sies Helmut; Stahl Wilhelm; Polidori M Cristina
In vitro antioxidant activity of 2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC), a vitamin E metabolite.
Free radical research 2002;36(8):915-21.
2002: Schewe Tankred; Kühn Hartmut; Sies Helmut
Flavonoids of cocoa inhibit recombinant human 5-lipoxygenase.
The Journal of nutrition 2002;132(7):1825-9.
2002: Brenneisen Peter; Wlaschek Meinhard; Schwamborn Edith; Schneider Lars-Alexander; Ma Wenjian; Sies Helmut; Scharffetter-Kochanek Karin
Activation of protein kinase CK2 is an early step in the ultraviolet B-mediated increase in interstitial collagenase (matrix metalloproteinase-1; MMP-1) and stromelysin-1 (MMP-3) protein levels in human dermal fibroblasts.
The Biochemical journal 2002;365(Pt 1):31-40.
2002: Radosavac Dragan; Graf Peter; Polidori M Cristina; Sies Helmut; Stahl Wilhelm
Tocopherol metabolites 2, 5, 7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) and 2, 7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman (gamma-CEHC) in human serum after a single dose of natural vitamin E.
European journal of nutrition 2002;41(3):119-24.
2002: Ale-Agha Niloofar; Stahl Wilhelm; Sies Helmut
(-)-Epicatechin effects in rat liver epithelial cells: stimulation of gap junctional communication and counteraction of its loss due to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Biochemical pharmacology 2002;63(12):2145-9.
2002: Jorge Soraia A C; Menck Carlos F M; Sies Helmut; Osborne Martin R; Phillips David H; Sarasin Alain; Stary Anne
Mutagenic fingerprint of ozone in human cells.
DNA repair 2002;1(5):369-78.
2002: Eichler Olaf; Sies Helmut; Stahl Wilhelm
Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblastst.
Photochemistry and photobiology 2002;75(5):503-6.
2002: Kröncke Klaus-Dietrich; Klotz Lars-Oliver; Suschek Christoph V; Sies Helmut
Comparing nitrosative versus oxidative stress toward zinc finger-dependent transcription. Unique role for NO.
The Journal of biological chemistry 2002;277(15):13294-301.
2002: Polidori M Cristina; Cherubini Antonio; Stahl Wilhelm; Senin Umberto; Sies Helmut; Mecocci Patrizia
Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome.
Free radical research 2002;36(3):265-8.
2002: Polidori Maria Cristina; Savino Ketty; Alunni Gianfranco; Freddio Michela; Senin Umberto; Sies Helmut; Stahl Wilhelm; Mecocci Patrizia
Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity.
Free radical biology & medicine 2002;32(2):148-52.
2002: Ostrakhovitch Elena A; Lordnejad Mohammad Reza; Schliess Freimut; Sies Helmut; Klotz Lars-Oliver
Copper ions strongly activate the phosphoinositide-3-kinase/Akt pathway independent of the generation of reactive oxygen species.
Archives of biochemistry and biophysics 2002;397(2):232-9.
2002: Klotz Lars-Oliver; Sies Helmut
Reversible conversion of nitroxyl anion to nitric oxide.
Methods in enzymology 2002;349():101-6.
2002: Arteel Gavin E; Klotz Lars-Oliver; Buchczyk Darius P; Sies Helmut
Selenoprotein P.
Methods in enzymology 2002;347():121-5.
2001: Schewe T; Sadik C; Klotz L O; Yoshimoto T; Kühn H; Sies H
Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase.
Biological chemistry 2001;382(12):1687-96.
2001: Lang K; Bolsen K; Stahl W; Ruzicka T; Sies H; Lehmann P; Fritsch C
The 5-aminolevulinic acid-induced porphyrin biosynthesis in benign and malignant cells of the skin.
Journal of photochemistry and photobiology. B, Biology 2001;65(1):29-34.
2001: Schroeder P; Zhang H; Klotz L O; Kalyanaraman B; Sies H
(-)-Epicatechin inhibits nitration and dimerization of tyrosine in hydrophilic as well as hydrophobic environments.
Biochemical and biophysical research communications 2001;289(5):1334-8.
2001: Aust O; Sies H; Stahl W; Polidori M C
Analysis of lipophilic antioxidants in human serum and tissues: tocopherols and carotenoids.
Journal of chromatography. A 2001;936(1-2):83-93.
2001: Onat D; Stahl W; Sies H
Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human fetal skin fibroblasts (HFFF2) and in rat liver epithelial cells (WB-F344).
Biochemical pharmacology 2001;62(8):1081-6.
2001: Mugesh G; du Mont W W; Sies H
Chemistry of biologically important synthetic organoselenium compounds.
Chemical reviews 2001;101(7):2125-79.
2001: Wagner G; Stettmaier K; Bors W; Sies H; Wagner E M; Reuter A; Weiher H
Enhanced gamma-glutamyl transpeptidase expression and superoxide production in Mpv17-/- glomerulosclerosis mice.
Biological chemistry 2001;382(7):1019-25.
2001: Schroeder P; Klotz L O; Buchczyk D P; Sadik C D; Schewe T; Sies H
Epicatechin selectively prevents nitration but not oxidation reactions of peroxynitrite.
Biochemical and biophysical research communications 2001;285(3):782-7.
2001: Junghans A; Sies H; Stahl W
Macular pigments lutein and zeaxanthin as blue light filters studied in liposomes.
Archives of biochemistry and biophysics 2001;391(2):160-4.
2001: Al-Mustafa A H; Sies H; Stahl W
Sulfur-to-nitrogen transnitrosation: transfer of nitric oxide from S-nitroso compounds to diethanolamine and the role of intermediate sulfur-to-sulfur transnitrosation.
Toxicology 2001;163(2-3):127-36.
2001: Buchczyk D P; Klotz L O; Lang K; Fritsch C; Sies H
High efficiency of 5-aminolevulinate-photodynamic treatment using UVA irradiation.
Carcinogenesis 2001;22(6):879-83.
2001: Suschek C V; Briviba K; Bruch-Gerharz D; Sies H; Kröncke K D; Kolb-Bachofen V
Even after UVA-exposure will nitric oxide protect cells from reactive oxygen intermediate-mediated apoptosis and necrosis.
Cell death and differentiation 2001;8(5):515-27.
2001: Stahl W; Heinrich U; Wiseman S; Eichler O; Sies H; Tronnier H
Dietary tomato paste protects against ultraviolet light-induced erythema in humans.
The Journal of nutrition 2001;131(5):1449-51.
2001: Polidori M C; Stahl W; Eichler O; Niestroj I; Sies H
Profiles of antioxidants in human plasma.
Free radical biology & medicine 2001;30(5):456-62.
2001: Kono H; Arteel G E; Rusyn I; Sies H; Thurman R G
Ebselen prevents early alcohol-induced liver injury in rats.
Free radical biology & medicine 2001;30(4):403-11.
2001: Bruch-Gerharz D; Stahl W; Gerharz C D; Megahed M; Wingerath T; Sies H; Ruzicka T
Accumulation of the xanthophyll lutein in skin amyloid deposits of systemic amyloidosis (al type).
The Journal of investigative dermatology 2001;116(1):196-7.
2001: Stahl W; Sies H
Effects of carotenoids and retinoids on gap junctional communication.
BioFactors (Oxford, England) 2001;15(2-4):95-8.
2001: Klotz L O; Holbrook N J; Sies H
UVA and singlet oxygen as inducers of cutaneous signaling events.
Current problems in dermatology 2001;29():95-113.
2000: Junghans A; Sies H; Stahl W
Carotenoid-containing unilamellar liposomes loaded with glutathione: a model to study hydrophobic-hydrophilic antioxidant interaction.
Free radical research 2000;33(6):801-8.
2000: Klotz L O; Schieke S M; Sies H; Holbrook N J
Peroxynitrite activates the phosphoinositide 3-kinase/Akt pathway in human skin primary fibroblasts.
The Biochemical journal 2000;352 Pt 1():219-25.
2000: Grether-Beck S; Bonizzi G; Schmitt-Brenden H; Felsner I; Timmer A; Sies H; Johnson J P; Piette J; Krutmann J
Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation.
The EMBO journal 2000;19(21):5793-800.
2000: Stock A; Sies H
Thyroid hormone receptors bind to an element in the connexin43 promoter.
Biological chemistry 2000;381(9-10):973-9.
2000: Gladilin S; Bidmon H J; Divanach A; Arteel G E; Witte O W; Zilles K; Sies H
Ebselen lowers plasma interleukin-6 levels and glial heme oxygenase-1 expression after focal photothrombotic brain ischemia.
Archives of biochemistry and biophysics 2000;380(2):237-42.
2000: Arteel G E; Schroeder P; Sies H
Reactions of peroxynitrite with cocoa procyanidin oligomers.
The Journal of nutrition 2000;130(8S Suppl):2100S-4S.
2000: Sies H; Arteel G E
Interaction of peroxynitrite with selenoproteins and glutathione peroxidase mimics.
Free radical biology & medicine 2000;28(10):1451-5.
2000: Mecocci P; Polidori M C; Troiano L; Cherubini A; Cecchetti R; Pini G; Straatman M; Monti D; Stahl W; Sies H; Franceschi C; Senin U
Plasma antioxidants and longevity: a study on healthy centenarians.
Free radical biology & medicine 2000;28(8):1243-8.
2000: Assmann A; Bonifacic M; Briviba K; Sies H; Asmus K D
One-electron reduction of selenomethionine oxide.
Free radical research 2000;32(4):371-6.
2000: Parnham M; Sies H
Ebselen: prospective therapy for cerebral ischaemia.
Expert opinion on investigational drugs 2000;9(3):607-19.
2000: Arteel G E; Franken S; Kappler J; Sies H
Binding of selenoprotein P to heparin: characterization with surface plasmon resonance.
Biological chemistry 2000;381(3):265-8.
2000: Stahl W; Heinrich U; Jungmann H; Sies H; Tronnier H
Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
The American journal of clinical nutrition 2000;71(3):795-8.
2000: Buchczyk D P; Briviba K; Hartl F U; Sies H
Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination.
Biological chemistry 2000;381(2):121-6.
2000: Jacob C; Arteel G E; Kanda T; Engman L; Sies H
Water-soluble organotellurium compounds: catalytic protection against peroxynitrite and release of zinc from metallothionein.
Chemical research in toxicology 2000;13(1):3-9.
2000: Panasenko O M; Sharov V S; Briviba K; Sies H
Interaction of peroxynitrite with carotenoids in human low density lipoproteins.
Archives of biochemistry and biophysics 2000;373(1):302-5.
2000: Stahl W; von Laar J; Martin H D; Emmerich T; Sies H
Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene.
Archives of biochemistry and biophysics 2000;373(1):271-4.
2000: Stahl W; Heinrich U; Jungmann H; Tronnier H; Sies H
Carotenoids in human skin: noninvasive measurement and identification of dermal carotenoids and carotenol esters.
Methods in enzymology 2000;319():494-502.
1999: Arteel G E; Sies H
Protection against peroxynitrite by cocoa polyphenol oligomers.
FEBS letters 1999;462(1-2):167-70.
1999: Sies H
Glutathione and its role in cellular functions.
Free radical biology & medicine 1999;27(9-10):916-21.
1999: Stahl W; Graf P; Brigelius-Flohé R; Wechter W; Sies H
Quantification of the alpha- and gamma-tocopherol metabolites 2,5,7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman and 2,7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman in human serum.
Analytical biochemistry 1999;275(2):254-9.
1999: Sharov V S; Briviba K; Sies H
Peroxynitrite diminishes gap junctional communication: protection by selenite supplementation.
IUBMB life 1999;48(4):379-84.
1999: Thiele J J; Hsieh S N; Briviba K; Sies H
Protein oxidation in human stratum corneum: susceptibility of keratins to oxidation in vitro and presence of a keratin oxidation gradient in vivo.
The Journal of investigative dermatology 1999;113(3):335-9.
1999: Clairmont A; Sies H; Ramachandran S; Lear J T; Smith A G; Bowers B; Jones P W; Fryer A A; Strange R C
Association of NAD(P)H:quinone oxidoreductase (NQO1) null with numbers of basal cell carcinomas: use of a multivariate model to rank the relative importance of this polymorphism and those at other relevant loci.
Carcinogenesis 1999;20(7):1235-40.
1999: Berneburg M; Grether-Beck S; Kürten V; Ruzicka T; Briviba K; Sies H; Krutmann J
Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion.
The Journal of biological chemistry 1999;274(22):15345-9.
1999: Teicher V B; Kucharski N; Martin H D; van der Saag P; Sies H; Stahl W
Biological activities of Apo-canthaxanthinoic acids related to gap junctional communication.
Archives of biochemistry and biophysics 1999;365(1):150-5.
1999: Schieke S M; Briviba K; Klotz L O; Sies H
Activation pattern of mitogen-activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation.
FEBS letters 1999;448(2-3):301-3.
1999: Fritsch C; Lehmann P; Stahl W; Schulte K W; Blohm E; Lang K; Sies H; Ruzicka T
Optimum porphyrin accumulation in epithelial skin tumours and psoriatic lesions after topical application of delta-aminolaevulinic acid.
British journal of cancer 1999;79(9-10):1603-8.
1999: Arteel G E; Briviba K; Sies H
Function of thioredoxin reductase as a peroxynitrite reductase using selenocystine or ebselen.
Chemical research in toxicology 1999;12(3):264-9.
1999: Arteel G E; Briviba K; Sies H
Protection against peroxynitrite.
FEBS letters 1999;445(2-3):226-30.
1999: Briviba K; Klotz L O; Sies H
Defenses against peroxynitrite.
Methods in enzymology 1999;301():301-11.
1998: Briviba K; Kissner R; Koppenol W H; Sies H
Kinetic study of the reaction of glutathione peroxidase with peroxynitrite.
Chemical research in toxicology 1998;11(12):1398-401.
1998: Lörper M; Clairmont A; Carlberg C; Sies H
Identification of two activating elements in the proximal promoter region of the human glutathione transferase-A1 and -A2 genes.
Archives of biochemistry and biophysics 1998;359(1):122-7.
1998: Klotz L O; Fritsch C; Briviba K; Tsacmacidis N; Schliess F; Sies H
Activation of JNK and p38 but not ERK MAP kinases in human skin cells by 5-aminolevulinate-photodynamic therapy.
Cancer research 1998;58(19):4297-300.
1998: Jösch C; Sies H; Akerboom T P
Hepatic mercapturic acid formation: involvement of cytosolic cysteinylglycine S-conjugate dipeptidase activity.
Biochemical pharmacology 1998;56(6):763-71.
1998: Arteel G E; Mostert V; Oubrahim H; Briviba K; Abel J; Sies H
Protection by selenoprotein P in human plasma against peroxynitrite-mediated oxidation and nitration.
Biological chemistry 1998;379(8-9):1201-5.
1998: Fritsch C; Homey B; Stahl W; Lehmann P; Ruzicka T; Sies H
Preferential relative porphyrin enrichment in solar keratoses upon topical application of delta-aminolevulinic acid methylester.
Photochemistry and photobiology 1998;68(2):218-21.
1998: Wingerath T; Sies H; Stahl W
Xanthophyll esters in human skin.
Archives of biochemistry and biophysics 1998;355(2):271-4.
1998: Stahl W; Junghans A; de Boer B; Driomina E S; Briviba K; Sies H
Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein.
FEBS letters 1998;427(2):305-8.
1998: Stahl W; Heinrich U; Jungmann H; von Laar J; Schietzel M; Sies H; Tronnier H
Increased dermal carotenoid levels assessed by noninvasive reflection spectrophotometry correlate with serum levels in women ingesting Betatene.
The Journal of nutrition 1998;128(5):903-7.
1998: Sies H; Dafré A L; Ji Y; Akerboom T P
Protein S-thiolation and redox regulation of membrane-bound glutathione transferase.
Chemico-biological interactions 1998;111-112():177-85.
1998: Sies H; Klotz L O; Sharov V S; Assmann A; Briviba K
Protection against peroxynitrite by selenoproteins.
Zeitschrift für Naturforschung. C, Journal of biosciences 1998;53(3-4):228-32.
1998: Briviba K; Tamler R; Klotz L O; Engman L; Cotgreave I A; Sies H
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
Biochemical pharmacology 1998;55(6):817-23.
1998: Herrmann G; Brenneisen P; Wlaschek M; Wenk J; Faisst K; Quel G; Hommel C; Goerz G; Ruzicka T; Krieg T; Sies H; Scharffetter-Kochanek K
Psoralen photoactivation promotes morphological and functional changes in fibroblasts in vitro reminiscent of cellular senescence.
Journal of cell science 1998;111 ( Pt 6)():759-67.
1998: Stock A; Sies H; Stahl W
Enhancement of gap junctional communication and connexin43 expression by thyroid hormones.
Biochemical pharmacology 1998;55(4):475-9.
1998: Assmann A; Briviba K; Sies H
Reduction of methionine selenoxide to selenomethionine by glutathione.
Archives of biochemistry and biophysics 1998;349(1):201-3.
1998: Stahl W; Sies H
The role of carotenoids and retinoids in gap junctional communication.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1998;68(6):354-9.
1997: von Herbay A; Stahl W; Niederau C; Sies H
Vitamin E improves the aminotransferase status of patients suffering from viral hepatitis C: a randomized, double-blind, placebo-controlled study.
Free radical research 1997;27(6):599-605.
1997: Clairmont A; Sies H
Evidence for a posttranscriptional effect of retinoic acid on connexin43 gene expression via the 3'-untranslated region.
FEBS letters 1997;419(2-3):268-70.
1997: Briviba K; Klotz L O; Sies H
Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems.
Biological chemistry 1997;378(11):1259-65.
1997: Morita A; Werfel T; Stege H; Ahrens C; Karmann K; Grewe M; Grether-Beck S; Ruzicka T; Kapp A; Klotz L O; Sies H; Krutmann J
Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy.
The Journal of experimental medicine 1997;186(10):1763-8.
1997: Panasenko O M; Panasenko O O; Briviba K; Sies H
Hypochlorite destroys carotenoids in low density lipoproteins thus decreasing their resistance to peroxidative modification.
Biochemistry. Biokhimii?a 1997;62(10):1140-5.
1997: Sies H; Sharov V S; Klotz L O; Briviba K
Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase.
The Journal of biological chemistry 1997;272(44):27812-7.
1997: Panasenko O M; Briviba K; Klotz L O; Sies H
Oxidative modification and nitration of human low-density lipoproteins by the reaction of hypochlorous acid with nitrite.
Archives of biochemistry and biophysics 1997;343(2):254-9.
1997: Gärtner C; Stahl W; Sies H
Lycopene is more bioavailable from tomato paste than from fresh tomatoes.
The American journal of clinical nutrition 1997;66(1):116-22.
1997: Schulz W A; Krummeck A; Rösinger I; Eickelmann P; Neuhaus C; Ebert T; Schmitz-Dräger B J; Sies H
Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies.
Pharmacogenetics 1997;7(3):235-9.
1997: Nicolai S; Sies H; Stahl W
Stimulation of gap junctional intercellular communication by thalidomide and thalidomide analogs in human skin fibroblasts.
Biochemical pharmacology 1997;53(10):1553-7.
1997: Klotz L O; Briviba K; Sies H
Singlet oxygen mediates the activation of JNK by UVA radiation in human skin fibroblasts.
FEBS letters 1997;408(3):289-91.
1997: Stahl W; Nicolai S; Briviba K; Hanusch M; Broszeit G; Peters M; Martin H D; Sies H
Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching.
Carcinogenesis 1997;18(1):89-92.
1997: Fritsch C; Abels C; Goetz A E; Stahl W; Bolsen K; Ruzicka T; Goerz G; Sies H
Porphyrins preferentially accumulate in a melanoma following intravenous injection of 5-aminolevulinic acid.
Biological chemistry 1997;378(1):51-7.
1997: Akerboom T P; Ji Y; Wagner G; Sies H
Subunit specificity and organ distribution of glutathione transferase-catalysed S-nitrosoglutathione formation from alkyl nitrites in the rat.
Biochemical pharmacology 1997;53(1):117-20.
1997: Sies H; Stahl W
Carotenoids and intercellular communication via gap junctions.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1997;67(5):364-7.
1997: Sies H; Masumoto H
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite.
Advances in pharmacology (San Diego, Calif.) 1997;38():229-46.
1996: Masumoto H; Kissner R; Koppenol W H; Sies H
Kinetic study of the reaction of ebselen with peroxynitrite.
FEBS letters 1996;398(2-3):179-82.
1996: Grether-Beck S; Olaizola-Horn S; Schmitt H; Grewe M; Jahnke A; Johnson J P; Briviba K; Sies H; Krutmann J
Activation of transcription factor AP-2 mediates UVA radiation- and singlet oxygen-induced expression of the human intercellular adhesion molecule 1 gene.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14586-91.
1996: von Herbay A; Stahl W; Niederau C; von Laar J; Strohmeyer G; Sies H
Diminished plasma levels of vitamin E in patients with severe viral hepatitis.
Free radical research 1996;25(6):461-6.
1996: Stahl W; Sies H
Lycopene: a biologically important carotenoid for humans?
Archives of biochemistry and biophysics 1996;336(1):1-9.
1996: Müschen M; Sies H; Schulz W A
Induction of mouse embryonal carcinoma cell differentiation and activation of the retinoic acid receptor beta 2 promoter by 1,25-dihydroxyvitamin D3.
Biological chemistry 1996;377(11):703-10.
1996: Clairmont A; Tessmann D; Sies H
Analysis of connexin43 gene expression induced by retinoic acid in F9 teratocarcinoma cells.
FEBS letters 1996;397(1):22-4.
1996: Epe B; Ballmaier D; Roussyn I; Briviba K; Sies H
DNA damage by peroxynitrite characterized with DNA repair enzymes.
Nucleic acids research 1996;24(21):4105-10.
1996: Brenneisen P; Oh J; Wlaschek M; Wenk J; Briviba K; Hommel C; Herrmann G; Sies H; Scharffetter-Kochanek K
Ultraviolet B wavelength dependence for the regulation of two major matrix-metalloproteinases and their inhibitor TIMP-1 in human dermal fibroblasts.
Photochemistry and photobiology 1996;64(5):877-85.
1996: Masumoto H; Sies H
The reaction of 2-(methylseleno)benzanilide with peroxynitrite.
Chemical research in toxicology 1996;9(7):1057-62.
1996: Briviba K; Roussyn I; Sharov V S; Sies H
Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen.
The Biochemical journal 1996;319 ( Pt 1)():13-5.
1996: Brenneisen P; Oh J; Wlaschek M; Wenk J; Briviba K; Hommel C; Herrmann G; Sies H; Scharffetter-Kochanek K
Ultraviolet B wavelength dependence for the regulation of two major matrix-metalloproteinases and their inhibitor TIMP-1 in human dermal fibroblasts.
Photochemistry and photobiology 1996;64(4):649-57.
1996: Dafré A L; Sies H; Akerboom T
Protein S-thiolation and regulation of microsomal glutathione transferase activity by the glutathione redox couple.
Archives of biochemistry and biophysics 1996;332(2):288-94.
1996: Kaufmann R; Wingerath T; Kirsch D; Stahl W; Sies H
Analysis of carotenoids and carotenol fatty acid esters by matrix-assisted laser desorption ionization (MALDI) and MALDI-post-source-decay mass spectrometry.
Analytical biochemistry 1996;238(2):117-28.
1996: Clairmont A; Tessman D; Stock A; Nicolai S; Stahl W; Sies H
Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear Induction of gap junctional intercellular communication by vitamin D in human skin fibroblasts is dependent on the nuclear vitamin D receptor.
Carcinogenesis 1996;17(6):1389-91.
1996: Roussyn I; Briviba K; Masumoto H; Sies H
Selenium-containing compounds protect DNA from single-strand breaks caused by peroxynitrite.
Archives of biochemistry and biophysics 1996;330(1):216-8.
1996: Briviba K; Saha-Möller C R; Adam W; Sies H
Formation of singlet oxygen in the thermal decomposition of 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane, a chemical source of triplet-excited ketones.
Biochemistry and molecular biology international 1996;38(4):647-51.
1996: von Laar J; Stahl W; Bolsen K; Goerz G; Sies H
Beta-carotene serum levels in patients with erythropoietic protoporphyria on treatment with the synthetic all-trans isomer or a natural isomeric mixture of beta-carotene.
Journal of photochemistry and photobiology. B, Biology 1996;33(2):157-62.
1996: Lorper M; Schulz W A; Morel F; Warskulat U; Sies H
Positive and negative regulatory regions in promoters of human glutathione transferase alpha genes.
Biological chemistry Hoppe-Seyler 1996;377(1):39-46.
1996: Masumoto H; Sies H
The reaction of ebselen with peroxynitrite.
Chemical research in toxicology 1996;9(1):262-7.
1996: Sies H; Schulz W A; Steenken S
Adjacent guanines as preferred sites for strand breaks in plasmid DNA irradiated with 193 nm and 248 nm UV laser light.
Journal of photochemistry and photobiology. B, Biology 1996;32(1-2):97-102.
1996: Ji Y; Akerboom T P; Sies H
Microsomal formation of S-nitrosoglutathione from organic nitrites: possible role of membrane-bound glutathione transferase.
The Biochemical journal 1996;313 ( Pt 2)():377-80.
1996: Sharov V S; Briviba K; Sies H
Assessment of the C-525 laser dye as a chemiluminescence sensitizer for lipid peroxidation in biological membranes: a comparison with chlorophyll-a.
Free radical biology & medicine 1996;21(6):833-43.
1996: Gärtner C; Stahl W; Sies H
Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human.
International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition 1996;66(2):119-25.
1996: Stahl W; Hanusch M; Sies H
4-oxo-retinoic acid is generated from its precursor canthaxanthin and enhances gap junctional communication in 10T1/2 cells.
Advances in experimental medicine and biology 1996;387():121-8.
1996: Di Mascio P; Briviba K; Bechara E J; Medeiros M H; Sies H
Reaction of peroxynitrite and hydrogen peroxide to produce singlet molecular oxygen (1deltag).
Methods in enzymology 1996;269():395-400.
1996: Schulz W A; Eickelmann P; Sies H
Free radicals in toxicology: redox cycling and NAD(P)H:quinone oxidoreductase.
Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement 1996;18():217-22.
1995: Wingerath T; Stahl W; Sies H
beta-Cryptoxanthin selectively increases in human chylomicrons upon ingestion of tangerine concentrate rich in beta-cryptoxanthin esters.
Archives of biochemistry and biophysics 1995;324(2):385-90.
1995: Sies H; Stahl W
Vitamins E and C, beta-carotene, and other carotenoids as antioxidants.
The American journal of clinical nutrition 1995;62(6 Suppl):1315S-1321S.
1995: Sies H; Krinsky N I
The present status of antioxidant vitamins and beta-carotene.
The American journal of clinical nutrition 1995;62(6 Suppl):1299S-1300S.
1995: Soboll S; Gründel S; Harris J; Kolb-Bachofen V; Ketterer B; Sies H
The content of glutathione and glutathione S-transferases and the glutathione peroxidase activity in rat liver nuclei determined by a non-aqueous technique of cell fractionation.
The Biochemical journal 1995;311 ( Pt 3)():889-94.
1995: Stahl W; Schwarz W; von Laar J; Sies H
All-trans beta-carotene preferentially accumulates in human chylomicrons and very low density lipoproteins compared with the 9-cis geometrical isomer.
The Journal of nutrition 1995;125(8):2128-33.
1995: Eickelmann P; Morel F; Schulz W A; Sies H
Turnover of glutathione S-transferase alpha mRNAs is accelerated by 12-O-tetradecanoyl phorbol-13-acetate in human hepatoma and colon carcinoma cell lines.
European journal of biochemistry / FEBS 1995;229(1):21-6.
1995: Hanusch M; Stahl W; Schulz W A; Sies H
Induction of gap junctional communication by 4-oxoretinoic acid generated from its precursor canthaxanthin.
Archives of biochemistry and biophysics 1995;317(2):423-8.
1995: Antonenkov V D; Sies H
Some basic properties of ascorbate-dependent antioxidative-defence factors from rat liver cytosol.
Chemico-biological interactions 1995;94(3):169-81.
1995: Nikawa T; Schulz W A; van den Brink C E; Hanusch M; van der Saag P; Stahl W; Sies H
Efficacy of all-trans-beta-carotene, canthaxanthin, and all-trans-, 9-cis-, and 4-oxoretinoic acids in inducing differentiation of an F9 embryonal carcinoma RAR beta-lacZ reporter cell line.
Archives of biochemistry and biophysics 1995;316(2):665-72.
1995: Wlaschek M; Briviba K; Stricklin G P; Sies H; Scharffetter-Kochanek K
Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase.
The Journal of investigative dermatology 1995;104(2):194-8.
1995: Akerboom T P; Sies H; Ziegler D M
The oxidation of ebselen metabolites to thiol oxidants catalyzed by liver microsomes and perfused rat liver.
Archives of biochemistry and biophysics 1995;316(1):220-6.
1995: Sies H
Ebselen.
Methods in enzymology 1995;252():341-2.
1994: Di Mascio P; Bechara E J; Medeiros M H; Briviba K; Sies H
Singlet molecular oxygen production in the reaction of peroxynitrite with hydrogen peroxide.
FEBS letters 1994;355(3):287-9.
1994: Morel F; Schulz W A; Sies H
Gene structure and regulation of expression of human glutathione S-transferases alpha.
Biological chemistry Hoppe-Seyler 1994;375(10):641-9.
1994: Wagner G; Schuch G; Akerboom T P; Sies H
Transport of ebselen in plasma and its transfer to binding sites in the hepatocyte.
Biochemical pharmacology 1994;48(6):1137-44.
1994: Stahl W; Nicolai S; Hanusch M; Sies H
Vitamin D influences gap junctional communication in C3H/10T 1/2 murine fibroblast cells.
FEBS letters 1994;352(1):1-3.
1994: Eickelmann P; Schulz W A; Rohde D; Schmitz-Dräger B; Sies H
Loss of heterozygosity at the NAD(P)H: quinone oxidoreductase locus associated with increased resistance against mitomycin C in a human bladder carcinoma cell line.
Biological chemistry Hoppe-Seyler 1994;375(7):439-45.
1994: Horbach M E; Sies H; Akerboom T P
Purification of rat liver plasma membrane glutathione transferase.
European journal of biochemistry / FEBS 1994;222(1):91-6.
1994: Medeiros M H; Di Mascio P; Gründel S; Soboll S; Sies H; Bechara E J
Catabolism of 5-aminolevulinic acid to CO2 by rat liver mitochondria.
Archives of biochemistry and biophysics 1994;310(1):205-9.
1994: Nikawa T; Schuch G; Wagner G; Sies H
Interaction of ebselen with glutathione S-transferase and papain in vitro.
Biochemical pharmacology 1994;47(6):1007-12.
1994: Clairmont A; Ebert T; Weber H; Zoidl C; Eickelmann P; Schulz W A; Sies H; Ryffel G U
Lowered amounts of the tissue-specific transcription factor LFB1 (HNF1) correlate with decreased levels of glutathione S-transferase alpha messenger RNA in human renal cell carcinoma.
Cancer research 1994;54(5):1319-23.
1994: Eickelmann P; Ebert T; Warskulat U; Schulz W A; Sies H
Expression of NAD(P)H:quinone oxidoreductase and glutathione S-transferases alpha and pi in human renal cell carcinoma and in kidney cancer-derived cell lines.
Carcinogenesis 1994;15(2):219-25.
1994: Nikawa T; Schuch G; Wagner G; Sies H
Interaction of albumin-bound ebselen with rat liver glutathione S-transferase and microsomal proteins.
Biochemistry and molecular biology international 1994;32(2):291-8.
1994: von Herbay A; de Groot H; Hegi U; Stremmel W; Strohmeyer G; Sies H
Low vitamin E content in plasma of patients with alcoholic liver disease, hemochromatosis and Wilson's disease.
Journal of hepatology 1994;20(1):41-6.
1994: Akerboom T P; Sies H
Transport of glutathione disulfide and glutathione S-conjugates in hepatocyte plasma membrane vesicles.
Methods in enzymology 1994;233():416-25.
1994: Sies H
Ebselen: a glutathione peroxidase mimic.
Methods in enzymology 1994;234():476-82.
1994: Schulz W A; Obendorf M S; Sies H
Localization of strand breaks in plasmid DNA treated with reactive oxygen species.
Methods in enzymology 1994;234():45-51.
1994: Stahl W; Sies H
Separation of geometrical isomers of beta-carotene and lycopene.
Methods in enzymology 1994;234():388-400.
1993: Oarada M; Stahl W; Sies H
Cellular levels of all-trans-beta-carotene under the influence of 9-cis-beta-carotene in FU-5 rat hepatoma cells.
Biological chemistry Hoppe-Seyler 1993;374(12):1075-81.
1993: Stahl W; Sies H
Physical quenching of singlet oxygen and cis-trans isomerization of carotenoids.
Annals of the New York Academy of Sciences 1993;691():10-9.
1993: Scharffetter-Kochanek K; Wlaschek M; Briviba K; Sies H
Singlet oxygen induces collagenase expression in human skin fibroblasts.
FEBS letters 1993;331(3):304-6.
1993: Briviba K; Fraser G; Sies H; Ketterer B
Distribution of the monochlorobimane-glutathione conjugate between nucleus and cytosol in isolated hepatocytes.
The Biochemical journal 1993;294 ( Pt 3)():631-3.
1993: Briviba K; Devasagayam T P; Sies H; Steenken S
Selective para hydroxylation of phenol and aniline by singlet molecular oxygen.
Chemical research in toxicology 1993;6(4):548-53.
1993: Sies H
Strategies of antioxidant defense.
European journal of biochemistry / FEBS 1993;215(2):213-9.
1993: Bartosz G; Sies H; Akerboom T P
Organic anions exhibit distinct inhibition patterns on the low-Km and high-Km transport of S-(2,4-dinitrophenyl)glutathione through the human erythrocyte membrane.
The Biochemical journal 1993;292 ( Pt 1)():171-4.
1993: Horbach M E; Sies H; Akerboom T P
Identification of a hepatic plasma membrane glutathione S-transferase activated by N-ethylmaleimide.
Biochimica et biophysica acta 1993;1148(1):61-6.
1993: Stahl W; Schwarz W; Sies H
Human serum concentrations of all-trans beta- and alpha-carotene but not 9-cis beta-carotene increase upon ingestion of a natural isomer mixture obtained from Dunaliella salina (Betatene).
The Journal of nutrition 1993;123(5):847-51.
1993: Stahl W; Sundquist A R; Hanusch M; Schwarz W; Sies H
Separation of beta-carotene and lycopene geometrical isomers in biological samples.
Clinical chemistry 1993;39(5):810-4.
1993: Sundquist A R; Hanusch M; Stahl W; Sies H
Cis/trans isomerization of carotenoids by the triplet carbonyl source 3-hydroxymethyl-3,4,4-trimethyl-1,2-dioxetane.
Photochemistry and photobiology 1993;57(5):785-91.
1993: Sies H
Damage to plasmid DNA by singlet oxygen and its protection.
Mutation research 1993;299(3-4):183-91.
1993: Sies H
Ebselen, a selenoorganic compound as glutathione peroxidase mimic.
Free radical biology & medicine 1993;14(3):313-23.
1993: Hansberg W; de Groot H; Sies H
Reactive oxygen species associated with cell differentiation in Neurospora crassa.
Free radical biology & medicine 1993;14(3):287-93.
1993: Devasagayam T P; Subramanian M; Pradhan D S; Sies H
Prevention of singlet oxygen-induced DNA damage by lipoate.
Chemico-biological interactions 1993;86(1):79-92.
1993: de Groot H; Hegi U; Sies H
Loss of alpha-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-1.
FEBS letters 1993;315(2):139-42.
1992: Antonenkov V D; Sies H
Ascorbate-dependent capacity of dialysed rat liver cytosol to prevent nonenzymatic lipid peroxidation.
Biological chemistry Hoppe-Seyler 1992;373(11):1111-6.
1992: Murphy M E; Scholich H; Sies H
Protection by glutathione and other thiol compounds against the loss of protein thiols and tocopherol homologs during microsomal lipid peroxidation.
European journal of biochemistry / FEBS 1992;210(1):139-46.
1992: Stahl W; Sies H
Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans.
The Journal of nutrition 1992;122(11):2161-6.
1992: Sies H; Stahl W; Sundquist A R
Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.
Annals of the New York Academy of Sciences 1992;669():7-20.
1992: Sies H; Menck C F
Singlet oxygen induced DNA damage.
Mutation research 1992;275(3-6):367-75.
1992: Klöne A; Hussnätter R; Sies H
Cloning, sequencing and characterization of the human alpha glutathione S-transferase gene corresponding to the cDNA clone pGTH2.
The Biochemical journal 1992;285 ( Pt 3)():925-8.
1992: Horakova L; Briviba K; Sies H
Antioxidant activity of the pyridoindole stobadine in liposomal and microsomal lipid peroxidation.
Chemico-biological interactions 1992;83(1):85-93.
1992: Wang J F; Komarov P; Sies H; de Groot H
Inhibition of superoxide and nitric oxide release and protection from reoxygenation injury by Ebselen in rat Kupffer cells.
Hepatology (Baltimore, Md.) 1992;15(6):1112-6.
1992: Hasse A; Schulz W A; Sies H
De novo methylation of transfected CAT gene plasmid constructs in F9 mouse embryonal carcinoma cells.
Biochimica et biophysica acta 1992;1131(1):16-22.
1992: Steenken S; Sundquist A R; Jovanovic S V; Crockett R; Sies H
Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one-electron-oxidized stobadine and quenching of singlet molecular oxygen.
Chemical research in toxicology 1992;5(3):355-60.
1992: Devasagayam T P; Werner T; Ippendorf H; Martin H D; Sies H
Synthetic carotenoids, novel polyene polyketones and new capsorubin isomers as efficient quenchers of singlet molecular oxygen.
Photochemistry and photobiology 1992;55(4):511-4.
1992: Stahl W; Schwarz W; Sundquist A R; Sies H
cis-trans isomers of lycopene and beta-carotene in human serum and tissues.
Archives of biochemistry and biophysics 1992;294(1):173-7.
1992: Ziegler D M; Graf P; Poulsen L L; Stahl W; Sies H
NADPH-dependent oxidation of reduced ebselen, 2-selenylbenzanilide, and of 2-(methylseleno)benzanilide catalyzed by pig liver flavin-containing monooxygenase.
Chemical research in toxicology 1992;5(2):163-6.
1992: Akerboom T P; Bartosz G; Sies H
Low- and high-Km transport of dinitrophenyl glutathione in inside out vesicles from human erythrocytes.
Biochimica et biophysica acta 1992;1103(1):115-9.
1992: Murphy M E; Kolvenbach R; Aleksis M; Hansen R; Sies H
Antioxidant depletion in aortic crossclamping ischemia: increase of the plasma alpha-tocopheryl quinone/alpha-tocopherol ratio.
Free radical biology & medicine 1992;13(2):95-100.
1991: Murphy M E; Sies H
Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(23):10860-4.
1991: Schulz W A; Eickelmann P; Hallbrucker C; Sies H; Häussinger D
Increase of beta-actin mRNA upon hypotonic perfusion of perfused rat liver.
FEBS letters 1991;292(1-2):264-6.
1991: Murphy M E; Piper H M; Watanabe H; Sies H
Nitric oxide production by cultured aortic endothelial cells in response to thiol depletion and replenishment.
The Journal of biological chemistry 1991;266(29):19378-83.
1991: Wang J F; Komarov P; Sies H; de Groot H
Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells.
The Biochemical journal 1991;279 ( Pt 1)():311-4.
1991: Akerboom T P; Narayanaswami V; Kunst M; Sies H
ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver.
The Journal of biological chemistry 1991;266(20):13147-52.
1991: Devasagayam T P; Steenken S; Obendorf M S; Schulz W A; Sies H
Formation of 8-hydroxy(deoxy)guanosine and generation of strand breaks at guanine residues in DNA by singlet oxygen.
Biochemistry 1991;30(25):6283-9.
1991: Devasagayam T P; Sundquist A R; Di Mascio P; Kaiser S; Sies H
Activity of thiols as singlet molecular oxygen quenchers.
Journal of photochemistry and photobiology. B, Biology 1991;9(1):105-16.
1991: Devasagayam T P; Di Mascio P; Kaiser S; Sies H
Singlet oxygen induced single-strand breaks in plasmid pBR322 DNA: the enhancing effect of thiols.
Biochimica et biophysica acta 1991;1088(3):409-12.
1991: Akerboom T; Schneider I; vom Dahl S; Sies H
Cholestasis and changes of portal pressure caused by chlorpromazine in the perfused rat liver.
Hepatology (Baltimore, Md.) 1991;13(2):216-21.
1991: Di Mascio P; Murphy M E; Sies H
Antioxidant defense systems: the role of carotenoids, tocopherols, and thiols.
The American journal of clinical nutrition 1991;53(1 Suppl):194S-200S.
1991: Sies H; Murphy M E
Role of tocopherols in the protection of biological systems against oxidative damage.
Journal of photochemistry and photobiology. B, Biology 1991;8(2):211-8.
1991: Di Mascio P; Kaiser S P; Devasagayam T P; Sies H
Biological significance of active oxygen species: in vitro studies on singlet oxygen-induced DNA damage and on the singlet oxygen quenching ability of carotenoids, tocopherols and thiols.
Advances in experimental medicine and biology 1991;283():71-7.
1990: Klöne A; Weidner U; Hussnätter R; Harris J; Meyer D; Peter S; Ketterer B; Sies H
Decreased expression of the glutathione S-transferases alpha and pi genes in human renal cell carcinoma.
Carcinogenesis 1990;11(12):2179-83.
1990: Di Mascio P; Devasagayam T P; Kaiser S; Sies H
Carotenoids, tocopherols and thiols as biological singlet molecular oxygen quenchers.
Biochemical Society transactions 1990;18(6):1054-6.
1990: Narayanaswami V; Sies H
Oxidative damage to mitochondria and protection by ebselen and other antioxidants.
Biochemical pharmacology 1990;40(7):1623-9.
1990: Weidner U; Peter S; Strohmeyer T; Hussnätter R; Ackermann R; Sies H
Inverse relationship of epidermal growth factor receptor and HER2/neu gene expression in human renal cell carcinoma.
Cancer research 1990;50(15):4504-9.
1990: John N J; Terlinden R; Fischer H; Evers M; Sies H
Microsomal metabolism of 2-(methylseleno) benzanilide.
Chemical research in toxicology 1990;3(3):199-203.
1990: Di Mascio P; Menck C F; Nigro R G; Sarasin A; Sies H
Singlet molecular oxygen induced mutagenicity in a mammalian SV40-based shuttle vector.
Photochemistry and photobiology 1990;51(3):293-8.
1990: Kaiser S; Di Mascio P; Murphy M E; Sies H
Physical and chemical scavenging of singlet molecular oxygen by tocopherols.
Archives of biochemistry and biophysics 1990;277(1):101-8.
1990: Scheschonka A; Murphy M E; Sies H
Temporal relationships between the loss of vitamin E, protein sulfhydryls and lipid peroxidation in microsomes challenged with different prooxidants.
Chemico-biological interactions 1990;74(3):233-52.
1990: Narayanaswami V; Sies H
Antioxidant activity of ebselen and related selenoorganic compounds in microsomal lipid peroxidation.
Free radical research communications 1990;10(4-5):237-44.
1990: Kaiser S; Di Mascio P; Murphy M E; Sies H
Quenching of singlet molecular oxygen by tocopherols.
Advances in experimental medicine and biology 1990;264():117-24.
1989: Di Mascio P; Kaiser S; Sies H
Lycopene as the most efficient biological carotenoid singlet oxygen quencher.
Archives of biochemistry and biophysics 1989;274(2):532-8.
1989: Peinado J; Sies H; Akerboom T P
Hepatic lipoate uptake.
Archives of biochemistry and biophysics 1989;273(2):389-95.
1989: Kunst M; Sies H; Akerboom T P
ATP-stimulated uptake of S-(2,4-dinitrophenyl)glutathione by plasma membrane vesicles from rat liver.
Biochimica et biophysica acta 1989;983(1):123-5.
1989: Kunst M; Sies H; Akerboom T P
S-(4-azidophenacyl)[35S]glutathione photoaffinity labeling of rat liver plasma membrane-associated proteins.
Biochimica et biophysica acta 1989;982(1):15-23.
1989: Di Mascio P; Wefers H; Do-Thi H P; Lafleur M V; Sies H
Singlet molecular oxygen causes loss of biological activity in plasmid and bacteriophage DNA and induces single-strand breaks.
Biochimica et biophysica acta 1989;1007(2):151-7.
1989: Scholich H; Murphy M E; Sies H
Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol.
Biochimica et biophysica acta 1989;1001(3):256-61.
1989: Rokutan K; Thomas J A; Sies H
Specific S-thiolation of a 30-kDa cytosolic protein from rat liver under oxidative stress.
European journal of biochemistry / FEBS 1989;179(1):233-9.
1988: Wefers H; Sies H
The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.
European journal of biochemistry / FEBS 1988;174(2):353-7.
1988: Akerboom T; Bultmann T; Sies H
Inhibition of biliary taurocholate excretion during menadione metabolism in perfused rat liver.
Archives of biochemistry and biophysics 1988;263(1):10-8.
1988: vom Dahl S; Graf P; Sies H
Hepatic inositol release upon hormonal stimulation of perfused rat liver.
The Biochemical journal 1988;251(3):843-8.
1988: Wagner G; Pott U; Bruckschen M; Sies H
Effects of 5-azacytidine and methyl-group deficiency on NAD(P)H: quinone oxidoreductase and glutathione S-transferase in liver.
The Biochemical journal 1988;251(3):825-9.
1988: Müller A; Gabriel H; Sies H; Terlinden R; Fischer H; Römer A
A novel biologically active selenooorganic compound--VII. Biotransformation of ebselen in perfused rat liver.
Biochemical pharmacology 1988;37(6):1103-9.
1988: Wefers H; Di Mascio P; Do-Thi H P; Schulte-Frohlinde D; Sies H
Effects of singlet oxygen on the biological activity of DNA and its involvement in single strand-break formation.
Basic life sciences 1988;49():473-7.
1987: Wefers H; Schulte-Frohlinde D; Sies H
Loss of transforming activity of plasmid DNA (pBR322) in E. coli caused by singlet molecular oxygen.
FEBS letters 1987;211(1):49-52.
1987: Sies H; Brigelius R; Graf P
Hormones, glutathione status and protein S-thiolation.
Advances in enzyme regulation 1987;26():175-89.
1987: Medeiros M H; Wefers H; Sies H
Generation of excited species catalyzed by horseradish peroxidase or hemin in the presence of reduced glutathione and H2O2.
Free radical biology & medicine 1987;3(2):107-10.
1987: Kehrer J P; Piper H M; Sies H
Xanthine oxidase is not responsible for reoxygenation injury in isolated-perfused rat heart.
Free radical research communications 1987;3(1-5):69-78.
1987: Müller A; Sies H
Alcohol, aldehydes and lipid peroxidation: current notions.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement 1987;1():67-74.

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