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Bo Siesjö

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
40
Smith, Maj-Lis
31
Kristián, Tibor
25
Li, Ping-An
21
He, Qing-Ping
15
Ouyang, Yi Bing
12
Gidö, Gunilla
9
Hu, Bingren
6
Elmér, Eskil
6
Lindvall, Olle
6
Uchino, Hiroyuki
5
Janelidze, Shorena
5
Kokaia, Zaal
4
Katsura, Ken-ichiro
4
Wieloch, Tadeusz
4
Yoshimoto, Tetsuyuki

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Publications

TOP 3
Siesjö Bo K
Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. (1992).
Uchino H; Morota S; Takahashi T; Ikeda Y; Kudo Y; Ishii N; Siesjö B K; Shibasaki F
A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins.
Katsura Ken-ichiro; Rodriguez de Turco Elena B; Siesjö Bo K; Bazan Nicolas G
Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia.

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All Publications

2008: Siesjö Bo K
Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. (1992).
Journal of neurosurgery 2008;108(3):616-31.
2006: Uchino H; Morota S; Takahashi T; Ikeda Y; Kudo Y; Ishii N; Siesjö B K; Shibasaki F
A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins.
Acta neurochirurgica. Supplement 2006;96():157-62.
2004: Katsura Ken-ichiro; Rodriguez de Turco Elena B; Siesjö Bo K; Bazan Nicolas G
Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia.
Brain research 2004;1030(1):133-40.
2004: Kurihara Junichi; Katsura Ken ichiro; Siesjö Bo K; Wieloch Tadeusz
Hyperglycemia and hypercapnia differently affect post-ischemic changes in protein kinases and protein phosphorylation in the rat cingulate cortex.
Brain research 2004;995(2):218-25.
2003: Han M; He Q P; Yong G; Siesjö B K; Li P A
NXY-059, a nitrone with free radical trapping properties inhibits release of cytochrome c after focal cerebral ischemia.
Cellular and molecular biology (Noisy-le-Grand, France) 2003;49(8):1249-52.
2003: Fujioka Masayuki; Taoka Toshiaki; Matsuo Yoshiyuki; Mishima Kenichi; Ogoshi Kumiko; Kondo Yoichi; Tsuda Masakazu; Fujiwara Michihiro; Asano Takao; Sakaki Toshisuke; Miyasaki Akihiro; Park Darren; Siesjö Bo K
Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration.
Annals of neurology 2003;54(6):732-47.
2002: Uchino Hiroyuki; Minamikawa-Tachino Reiko; Kristián Tibor; Perkins Guy; Narazaki Michiko; Siesjö Bo K; Shibasaki Futoshi
Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition.
Neurobiology of disease 2002;10(3):219-33.
2002: Yoshimoto Tetsuyuki; Kanakaraj Palanisamy; Ying Ma Jing; Cheng Mingshan; Kerr Irene; Malaiyandi Latha; Watson Jenny A; Siesjö Bo K; Maples Kirk R
NXY-059 maintains Akt activation and inhibits release of cytochrome C after focal cerebral ischemia.
Brain research 2002;947(2):191-8.
2002: Yoshimoto Tetsuyuki; Kristián Tibor; Hu Bingren; Ouyang Yi Bing; Siesjö Bo K
Effect of NXY-059 on secondary mitochondrial dysfunction after transient focal ischemia; comparison with cyclosporin A.
Brain research 2002;932(1-2):99-109.
2001: Kristian T; Bernardi P; Siesjö B K
Acidosis promotes the permeability transition in energized mitochondria: implications for reperfusion injury.
Journal of neurotrauma 2001;18(10):1059-74.
2001: Li P A; He Q P; Csiszar K; Siesjö B K
Does long-term glucose infusion reduce brain damage after transient cerebral ischemia?
Brain research 2001;912(2):203-5.
2001: Hu B R; Janelidze S; Ginsberg M D; Busto R; Perez-Pinzon M; Sick T J; Siesjö B K; Liu C L
Protein aggregation after focal brain ischemia and reperfusion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(7):865-75.
2001: Li P A; Rasquinha I; He Q P; Siesjö B K; Csiszár K; Boyd C D; MacManus J P
Hyperglycemia enhances DNA fragmentation after transient cerebral ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(5):568-76.
2001: Yoshimoto T; Uchino H; He Q P; Li P A; Siesjö B K
Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat.
Brain research 2001;899(1-2):148-58.
2001: Li P; He Q P; Ouyang Y B; Liu C L; Hu B R; Siesjö B K
Early release of cytochrome C and activation of caspase-3 in hyperglycemic rats subjected to transient forebrain ischemia.
Brain research 2001;896(1-2):69-76.
2001: Li P A; He Q P; Siesjö B K
Effects of intracarotid arterial injection of cyclosporin A and spontaneous hypothermia on brain damage incurred after a long period of global ischemia.
Brain research 2001;890(2):306-13.
2001: Janelidze S; Hu B R; Siesjö P; Siesjö B K
Alterations of Akt1 (PKBalpha) and p70(S6K) in transient focal ischemia.
Neurobiology of disease 2001;8(1):147-54.
2001: Li P A; He Q P; Yi-Bing O; Hu B R; Siesjö B K
Phosphorylation of extracellular signal-regulated kinase after transient cerebral ischemia in hyperglycemic rats.
Neurobiology of disease 2001;8(1):127-35.
2000: Katsura K; Rodriguez de Turco E B; Kristián T; Folbergrová J; Bazan N G; Siesjö B K
Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain.
Journal of neurochemistry 2000;75(6):2521-7.
2000: Ouyang Y B; He Q P; Zhang X H; Wang G X; Siesjö B K; Hu B R
Alteration of cyclic adenosine monophosphate response element binding protein in rat brain after hypoglycemic coma.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(11):1550-6.
2000: Hu B R; Liu C L; Ouyang Y; Blomgren K; Siesjö B K
Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(9):1294-300.
2000: Ouyang Y B; Zhang X H; He Q P; Wang G X; Siesjö B K; Hu B R
Differential phosphorylation at Ser473 and Thr308 of Akt-1 in rat brain following hypoglycemic coma.
Brain research 2000;876(1-2):191-5.
2000: Li P A; Kristián T; He Q P; Siesjö B K
Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia.
Experimental neurology 2000;165(1):153-63.
2000: Ouyang Y B; He Q P; Li P A; Janelidze S; Wang G X; Siesjö B K
Is neuronal injury caused by hypoglycemic coma of the necrotic or apoptotic type?
Neurochemical research 2000;25(5):661-7.
2000: Kristián T; Gertsch J; Bates T E; Siesjö B K
Characteristics of the calcium-triggered mitochondrial permeability transition in nonsynaptic brain mitochondria: effect of cyclosporin A and ubiquinone O.
Journal of neurochemistry 2000;74(5):1999-2009.
2000: Nakai A; Asakura H; Taniuchi Y; Koshino T; Araki T; Siesjö B K
Effect of alpha-phenyl-N-tert-butyl nitrone (PBN) on fetal cerebral energy metabolism during intrauterine ischemia and reperfusion in rats.
Pediatric research 2000;47(4 Pt 1):451-6.
2000: Li P A; Shuaib A; Miyashita H; He Q P; Siesjö B K; Warner D S
Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia.
Stroke; a journal of cerebral circulation 2000;31(1):183-92.
1999: Katsura K; Kurihara J; Siesjö B K; Wieloch T
Acidosis enhances translocation of protein kinase C but not Ca(2+)/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia.
Brain research 1999;849(1-2):119-27.
1999: Li P A; Liu G J; He Q P; Floyd R A; Siesjö B K
Production of hydroxyl free radical by brain tissues in hyperglycemic rats subjected to transient forebrain ischemia.
Free radical biology & medicine 1999;27(9-10):1033-40.
1999: Ouyang Y B; Tan Y; Comb M; Liu C L; Martone M E; Siesjö B K; Hu B R
Survival- and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(10):1126-35.
1999: Yoshimoto T; Siesjö B K
Posttreatment with the immunosuppressant cyclosporin A in transient focal ischemia.
Brain research 1999;839(2):283-91.
1999: Li P A; He Q P; Miyashita H; Howllet W; Siesjö B K; Shuaib A
Hypothermia ameliorates ischemic brain damage and suppresses the release of extracellular amino acids in both normo- and hyperglycemic subjects.
Experimental neurology 1999;158(1):242-53.
1999: Kuroda S; Janelidze S; Siesjö B K
The immunosuppressants cyclosporin A and FK506 equally ameliorate brain damage due to 30-min middle cerebral artery occlusion in hyperglycemic rats.
Brain research 1999;835(2):148-53.
1999: Kuroda S; Tsuchidate R; Smith M L; Maples K R; Siesjö B K
Neuroprotective effects of a novel nitrone, NXY-059, after transient focal cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(7):778-87.
1999: Folbergrová J; He Q P; Li P A; Smith M L; Siesjö B K
The effect of alpha-phenyl-N-tert-butyl nitrone on bioenergetic state in substantia nigra following flurothyl-induced status epilepticus in rats.
Neuroscience letters 1999;266(2):121-4.
1999: Gisselsson L; Smith M L; Siesjö B K
Hyperglycemia and focal brain ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(3):288-97.
1999: Siesjö B K; Elmér E; Janelidze S; Keep M; Kristián T; Ouyang Y B; Uchino H
Role and mechanisms of secondary mitochondrial failure.
Acta neurochirurgica. Supplement 1999;73():7-13.
1998: Uchino H; Elmér E; Uchino K; Li P A; He Q P; Smith M L; Siesjö B K
Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat.
Brain research 1998;812(1-2):216-26.
1998: Li P A; Vogel J; Smith M; He Q P; Kuschinsky W; Siesjö B K
Capillary patency after transient middle cerebral artery occlusion of 2 h duration.
Neuroscience letters 1998;253(3):191-4.
1998: Li C; Li P A; He Q P; Ouyang Y B; Siesjö B K
Effects of streptozotocin-induced hyperglycemia on brain damage following transient ischemia.
Neurobiology of disease 1998;5(2):117-28.
1998: Li P A; Gisselsson L; Keuker J; Vogel J; Smith M L; Kuschinsky W; Siesjö B K
Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction.
Brain research 1998;804(1):36-44.
1998: Kristián T; Gidö G; Kuroda S; Schütz A; Siesjö B K
Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1998;120(4):503-9.
1998: Gisselsson L; Smith M L; Siesjö B K
Influence of hypoglycemic coma on brain water and osmolality.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1998;120(4):461-9.
1998: Kristián T; Siesjö B K
Calcium in ischemic cell death.
Stroke; a journal of cerebral circulation 1998;29(3):705-18.
1998: Li P A; Vogel J; He Q P; Smith M L; Kuschinsky W; Siesjö B K
Preischemic hyperglycemia leads to rapidly developing brain damage with no change in capillary patency.
Brain research 1998;782(1-2):175-83.
1997: Li P A; Siesjö B K
Role of hyperglycaemia-related acidosis in ischaemic brain damage.
Acta physiologica Scandinavica 1997;161(4):567-80.
1997: Kuroda S; Nakai A; Kristían T; Siesjö B K
The calmodulin antagonist trifluoperazine in transient focal brain ischemia in rats. Anti-ischemic effect and therapeutic window.
Stroke; a journal of cerebral circulation 1997;28(12):2539-44.
1997: Uchino H; Lindvall O; Siesjö B K; Kokaia Z
Hyperglycemia and hypercapnia suppress BDNF gene expression in vulnerable regions after transient forebrain ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(12):1303-8.
1997: Canevari L; Kuroda S; Bates T E; Clark J B; Siesjö B K
Activity of mitochondrial respiratory chain enzymes after transient focal ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(11):1166-9.
1997: Tsuchidate R; He Q P; Smith M L; Siesjö B K
Regional cerebral blood flow during and after 2 hours of middle cerebral artery occlusion in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(10):1066-73.
1997: Albayrak S; Zhao Q; Siesjö B K; Smith M L
Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury.
Acta neuropathologica 1997;94(2):158-63.
1997: Li P A; Uchino H; Elmér E; Siesjö B K
Amelioration by cyclosporin A of brain damage following 5 or 10 min of ischemia in rats subjected to preischemic hyperglycemia.
Brain research 1997;753(1):133-40.
1997: Folbergrová J; Li P A; Uchino H; Smith M L; Siesjö B K
Changes in the bioenergetic state of rat hippocampus during 2.5 min of ischemia, and prevention of cell damage by cyclosporin A in hyperglycemic subjects.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1997;114(1):44-50.
1997: Gidö G; Kristián T; Siesjö B K
Extracellular potassium in a neocortical core area after transient focal ischemia.
Stroke; a journal of cerebral circulation 1997;28(1):206-10.
1997: Nakai A; Kuroda S; Kristián T; Siesjö B K
The immunosuppressant drug FK506 ameliorates secondary mitochondrial dysfunction following transient focal cerebral ischemia in the rat.
Neurobiology of disease 1997;4(3-4):288-300.
1997: He Q P; Smith M L; Li P A; Siesjö B K
Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap alpha phenyl-N-tert-butyl nitrone.
Free radical biology & medicine 1997;22(5):917-22.
1997: Kristián T; Siesjö B K
Changes in ionic fluxes during cerebral ischaemia.
International review of neurobiology 1997;40():27-45.
1996: Uchino H; Smith M L; Bengzon J; Lundgren J; Siesjö B K
Characteristics of postischemic seizures in hyperglycemic rats.
Journal of the neurological sciences 1996;139(1):21-7.
1996: Katsura K; Folbergrová J; Siesjö B K
Changes in labile energy metabolites, redox state and intracellular pH in postischemic brain of normo- and hyperglycemic rats.
Brain research 1996;726(1-2):57-63.
1996: Kokaia Z; Nawa H; Uchino H; Elmér E; Kokaia M; Carnahan J; Smith M L; Siesjö B K; Lindvall O
Regional brain-derived neurotrophic factor mRNA and protein levels following transient forebrain ischemia in the rat.
Brain research. Molecular brain research 1996;38(1):139-44.
1996: Siesjö B K; Siesjö P
Mechanisms of secondary brain injury.
European journal of anaesthesiology 1996;13(3):247-68.
1996: Pahlmark K; Siesjö B K
Effects of the spin trap-alpha-phenyl-N-tert-butyl nitrone (PBN) in transient forebrain ischaemia in the rat.
Acta physiologica Scandinavica 1996;157(1):41-51.
1996: Kuroda S; Katsura K; Hillered L; Bates T E; Siesjö B K
Delayed treatment with alpha-phenyl-N-tert-butyl nitrone (PBN) attenuates secondary mitochondrial dysfunction after transient focal cerebral ischemia in the rat.
Neurobiology of disease 1996;3(2):149-57.
1996: Kuroda S; Katsura K I; Tsuchidate R; Siesjö B K
Secondary bioenergetic failure after transient focal ischaemia is due to mitochondrial injury.
Acta physiologica Scandinavica 1996;156(2):149-50.
1996: Siesjö B K; Katsura K; Kristián T
Acidosis-related damage.
Advances in neurology 1996;71():209-33; discussion 234-6.
1996: Kristián T; Ouyang Y; Siesjö B K
Calcium-induced neuronal cell death in vivo and in vitro: are the pathophysiologic mechanisms different?
Advances in neurology 1996;71():107-113; discussion 113-8.
1996: Siesjö B K; Katsura K I; Kristián T; Li P A; Siesjö P
Molecular mechanisms of acidosis-mediated damage.
Acta neurochirurgica. Supplement 1996;66():8-14.
1995: Uchino H; Elmér E; Uchino K; Lindvall O; Siesjö B K
Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat.
Acta physiologica Scandinavica 1995;155(4):469-71.
1995: Kokaia Z; Zhao Q; Kokaia M; Elmér E; Metsis M; Smith M L; Siesjö B K; Lindvall O
Regulation of brain-derived neurotrophic factor gene expression after transient middle cerebral artery occlusion with and without brain damage.
Experimental neurology 1995;136(1):73-88.
1995: Siesjö B K; Katsura K; Zhao Q; Folbergrová J; Pahlmark K; Siesjö P; Smith M L
Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis.
Journal of neurotrauma 1995;12(5):943-56.
1995: Folbergrová J; Zhao Q; Katsura K; Siesjö B K
N-tert-butyl-alpha-phenylnitrone improves recovery of brain energy state in rats following transient focal ischemia.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):5057-61.
1995: Siesjö B K; Zhao Q; Pahlmark K; Siesjö P; Katsura K; Folbergrová J
Glutamate, calcium, and free radicals as mediators of ischemic brain damage.
The Annals of thoracic surgery 1995;59(5):1316-20.
1995: Li P A; Shamloo M; Katsura K i; Smith M L; Siesjö B K
Critical values for plasma glucose in aggravating ischaemic brain damage: correlation to extracellular pH.
Neurobiology of disease 1995;2(2):97-108.
1995: OuYang Y B; Kristián T; Kristiánová V; Mellergård P; Siesjö B K
The influence of calcium transients on intracellular pH in cortical neurons in primary culture.
Brain research 1995;676(2):307-13.
1995: Siesjö B K; Katsura K; Kristián T
The biochemical basis of cerebral ischemic damage.
Journal of neurosurgical anesthesiology 1995;7(1):47-52.
1995: Kristián T; Gidö G; Siesjö B K
The influence of acidosis on hypoglycemic brain damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1995;15(1):78-87.
1995: Memezawa H; Zhao Q; Smith M L; Siesjö B K
Hyperthermia nullifies the ameliorating effect of dizocilpine maleate (MK-801) in focal cerebral ischemia.
Brain research 1995;670(1):48-52.
1995: Ekholm A; Kristián T; Siesjö B K
Influence of hyperglycemia and of hypercapnia on cellular calcium transients during reversible brain ischemia.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1995;104(3):462-6.
1995: Li P A; Kristián T; Katsura K; Shamloo M; Siesjö B K
The influence of insulin-induced hypoglycemia on the calcium transients accompanying reversible forebrain ischemia in the rat.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1995;105(3):363-9.
1994: Siesjö B K
Calcium-mediated processes in neuronal degeneration.
Annals of the New York Academy of Sciences 1994;747():140-61.
1994: Gidö G; Kristián T; Siesjö B K
Induced spreading depressions in energy-compromised neocortical tissue: calcium transients and histopathological correlates.
Neurobiology of disease 1994;1(1-2):31-41.
1994: Zhao Q; Pahlmark K; Smith M L; Siesjö B K
Delayed treatment with the spin trap alpha-phenyl-N-tert-butyl nitrone (PBN) reduces infarct size following transient middle cerebral artery occlusion in rats.
Acta physiologica Scandinavica 1994;152(3):349-50.
1994: Katsura K; Kristián T; Siesjö B K
Energy metabolism, ion homeostasis, and cell damage in the brain.
Biochemical Society transactions 1994;22(4):991-6.
1994: Uchino H; Lundgren J; Smith M L; Siesjö B K
Preischemic hyperglycemia leads to delayed postischemic hyperthermia.
Stroke; a journal of cerebral circulation 1994;25(9):1825-9.
1994: Mellergård P; Ou-Yang Y; Siesjö B K
Relationship between intra- and extracellular pH in primary cultures of rat astrocytes.
The American journal of physiology 1994;267(2 Pt 1):C581-9.
1994: Li P A; Shamloo M; Smith M L; Katsura K; Siesjö B K
The influence of plasma glucose concentrations on ischemic brain damage is a threshold function.
Neuroscience letters 1994;177(1-2):63-5.
1994: Katsura K; Kristián T; Nair R; Siesjö B K
Regulation of intra- and extracellular pH in the rat brain in acute hypercapnia: a re-appraisal.
Brain research 1994;651(1-2):47-56.
1994: Zhao Q; Memezawa H; Smith M L; Siesjö B K
Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament.
Brain research 1994;649(1-2):253-9.
1994: Ou-Yang Y; Kristián T; Mellergård P; Siesjö B K
The influence of pH on glutamate- and depolarization-induced increases of intracellular calcium concentration in cortical neurons in primary culture.
Brain research 1994;646(1):65-72.
1994: Katsura K; Folbergrová J; Gidö G; Siesjö B K
Functional, metabolic, and circulatory changes associated with seizure activity in the postischemic brain.
Journal of neurochemistry 1994;62(4):1511-5.
1994: Zhao Q; Smith M L; Siesjö B K
The omega-conopeptide SNX-111, an N-type calcium channel blocker, dramatically ameliorates brain damage due to transient focal ischaemia.
Acta physiologica Scandinavica 1994;150(4):459-61.
1994: Kristián T; Katsura K; Gidö G; Siesjö B K
The influence of pH on cellular calcium influx during ischemia.
Brain research 1994;641(2):295-302.
1994: Katsura K; Kristián T; Smith M L; Siesjö B K
Acidosis induced by hypercapnia exaggerates ischemic brain damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1994;14(2):243-50.
1994: Gidö G; Kristián T; Katsura K; Siesjö B K
The influence of repeated spreading depression-induced calcium transients on neuronal viability in moderately hypoglycemic rats.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1994;97(3):397-403.
1994: Lundgren J; Smith M L; Blennow G; Siesjö B K
Hyperthermia aggravates and hypothermia ameliorates epileptic brain damage.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1994;99(1):43-55.
1994: OuYang Y B; Mellergård P; Kristián T; Kristiánova V; Siesjö B K
Influence of acid-base changes on the intracellular calcium concentration of neurons in primary culture.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1994;101(2):265-71.
1994: Mellergård P; Ouyang Y B; Siesjö B K
The regulation of intracellular pH is strongly dependent on extracellular pH in cultured rat astrocytes and neurons.
Acta neurochirurgica. Supplementum 1994;60():34-7.
1993: Kristián T; Gidö G; Siesjö B K
Brain calcium metabolism in hypoglycemic coma.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(6):955-61.
1993: Katsura K; Rodriguez de Turco E B; Folbergrová J; Bazan N G; Siesjö B K
Coupling among energy failure, loss of ion homeostasis, and phospholipase A2 and C activation during ischemia.
Journal of neurochemistry 1993;61(5):1677-84.
1993: Ou-yang Y; Mellergård P; Siesjö B K
Regulation of intracellular pH in single rat cortical neurons in vitro: a microspectrofluorometric study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(5):827-40.
1993: Katsura K; Folbergrová J; Bengtsson F; Kristián T; Gidö G; Siesjö B K
Recovery of mitochondrial and plasma membrane function following hypoglycemic coma: coupling of ATP synthesis, K+ transport, and changes in extra- and intracellular pH.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(5):820-6.
1993: Kokaia Z; Gidö G; Ringstedt T; Bengzon J; Kokaia M; Siesjö B K; Persson H; Lindvall O
Rapid increase of BDNF mRNA levels in cortical neurons following spreading depression: regulation by glutamatergic mechanisms independent of seizure activity.
Brain research. Molecular brain research 1993;19(4):277-86.
1993: Katsura K; Mellergård P; Theander S; Ouyang Y B; Siesjö B K
Buffer capacity of rat cortical tissue as well as of cultured neurons and astrocytes.
Brain research 1993;618(2):283-94.
1993: Pahlmark K; Folbergrová J; Smith M L; Siesjö B K
Effects of dimethylthiourea on selective neuronal vulnerability in forebrain ischemia in rats.
Stroke; a journal of cerebral circulation 1993;24(5):731-6; discussion 736-7.
1993: Ekholm A; Katsura K; Siesjö B K
Coupling of energy failure and dissipative K+ flux during ischemia: role of preischemic plasma glucose concentration.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(2):193-200.
1993: Ekholm A; Katsura K; Kristián T; Liu M; Folbergrová J; Siesjö B K
Coupling of cellular energy state and ion homeostasis during recovery following brain ischemia.
Brain research 1993;604(1-2):185-91.
1993: Gidö G; Katsura K; Kristian T; Siesjö B K
Influence of plasma glucose concentration on rat brain extracellular calcium transients during spreading depression.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):179-82.
1993: Folbergrová J; Kiyota Y; Pahlmark K; Memezawa H; Smith M L; Siesjö B K
Does ischemia with reperfusion lead to oxidative damage to proteins in the brain?
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(1):145-52.
1993: Siesjö B K; Katsura K; Mellergård P; Ekholm A; Lundgren J; Smith M L
Acidosis-related brain damage.
Progress in brain research 1993;96():23-48.
1993: Mellergård P; Ouyang Y B; Siesjö B K
Intracellular pH regulation in cultured rat astrocytes in CO2/HCO3(-)-containing media.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1993;95(3):371-80.
1993: Kiyota Y; Pahlmark K; Memezawa H; Smith M L; Siesjö B K
Free radicals and brain damage due to transient middle cerebral artery occlusion: the effect of dimethylthiourea.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1993;95(3):388-96.
1992: Kristián T; Katsura K; Siesjö B K
The influence of moderate hypothermia on cellular calcium uptake in complete ischaemia: implications for the excitotoxic hypothesis.
Acta physiologica Scandinavica 1992;146(4):531-2.
1992: Ekholm A; Siesjö B K
A technique for brain temperature control during ischemia, suitable for measurements with ion-sensitive microelectrodes.
Journal of neurosurgical anesthesiology 1992;4(4):272-7.
1992: Siesjö B K
Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment.
Journal of neurosurgery 1992;77(3):337-54.
1992: Gisselsson L; Smith M L; Siesjö B K
Influence of preischemic hyperglycemia on osmolality and early postischemic edema in the rat brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(5):809-16.
1992: Katsura K; Minamisawa H; Ekholm A; Folbergrová J; Siesjö B K
Changes of labile metabolites during anoxia in moderately hypo- and hyperthermic rats: correlation to membrane fluxes of K+.
Brain research 1992;590(1-2):6-12.
1992: Siesjö B K
Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology.
Journal of neurosurgery 1992;77(2):169-84.
1992: Ohta S; Gidö G; Siesjö B K
Influence of ischemia on blood-brain and blood-CSF calcium transport.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(3):525-8.
1992: Memezawa H; Smith M L; Siesjö B K
Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats.
Stroke; a journal of cerebral circulation 1992;23(4):552-9.
1992: Katsura K; Ekholm A; Siesjö B K
Tissue PCO2 in brain ischemia related to lactate content in normo- and hypercapnic rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(2):270-80.
1992: Lindvall O; Ernfors P; Bengzon J; Kokaia Z; Smith M L; Siesjö B K; Persson H
Differential regulation of mRNAs for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the adult rat brain following cerebral ischemia and hypoglycemic coma.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(2):648-52.
1992: Folbergrová J; Memezawa H; Smith M L; Siesjö B K
Focal and perifocal changes in tissue energy state during middle cerebral artery occlusion in normo- and hyperglycemic rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1992;12(1):25-33.
1992: Memezawa H; Minamisawa H; Smith M L; Siesjö B K
Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1992;89(1):67-78.
1992: Agardh C D; Smith M L; Siesjö B K
The influence of hypothermia on hypoglycemia-induced brain damage in the rat.
Acta neuropathologica 1992;83(4):379-85.
1992: Ekholm A; Asplund B; Siesjö B K
Perturbation of cellular energy state in complete ischemia: relationship to dissipative ion fluxes.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1992;90(1):47-53.
1992: Mellergård P E; Ouyang Y B; Siesjö B K
The regulation of intracellular pH in cultured astrocytes and neuroblastoma cells, and its dependence on extracellular pH in a HCO3-free solution.
Canadian journal of physiology and pharmacology 1992;70 Suppl():S293-300.
1992: Katsura K; Ekholm A; Siesjö B K
Coupling among changes in energy metabolism, acid-base homeostasis, and ion fluxes in ischemia.
Canadian journal of physiology and pharmacology 1992;70 Suppl():S170-5.
1991: Mellergård P E; Siesjö B K
Astrocytes fail to regulate intracellular pH at moderately reduced extracellular pH.
Neuroreport 1991;2(11):695-8.
1991: Lundgren J; Zhang H; Agardh C D; Smith M L; Evans P J; Halliwell B; Siesjö B K
Acidosis-induced ischemic brain damage: are free radicals involved?
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(4):587-96.
1991: Katsura K; Ekholm A; Asplund B; Siesjö B K
Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(4):597-9.
1991: Ekholm A; Katsura K; Siesjö B K
Tissue lactate content and tissue PCO2 in complete brain ischaemia: implications for compartmentation of H+.
Neurological research 1991;13(2):74-6.
1991: Ohta S; Smith M L; Siesjö B K
The effect of a dihydropyridine calcium antagonist (isradipine) on selective neuronal necrosis.
Journal of the neurological sciences 1991;103(1):109-15.
1991: Cardell M; Siesjö B K; Wieloch T
Changes in pyruvate dehydrogenase complex activity during and following severe insulin-induced hypoglycemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1991;11(1):122-8.
1991: Lundgren J; Smith M L; Siesjö B K
Influence of moderate hypothermia on ischemic brain damage incurred under hyperglycemic conditions.
Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale 1991;84(1):91-101.
1991: Siesjö B K; Memezawa H; Smith M L
Neurocytotoxicity: pharmacological implications.
Fundamental & clinical pharmacology 1991;5(9):755-67.
1990: Folbergrová J; Minamisawa H; Ekholm A; Siesjö B K
Phosphorylase alpha and labile metabolites during anoxia: correlation to membrane fluxes of K+ and Ca2+.
Journal of neurochemistry 1990;55(5):1690-6.
1990: Siesjö B K; Ekholm A; Katsura K; Theander S
Acid-base changes during complete brain ischemia.
Stroke; a journal of cerebral circulation 1990;21(11 Suppl):III194-9.
1990: Minamisawa H; Smith M L; Siesjö B K
The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia.
Annals of neurology 1990;28(1):26-33.
1990: Lundgren J; Cardell M; Wieloch T; Siesjö B K
Preischemic hyperglycemia and postischemic alteration of rat brain pyruvate dehydrogenase activity.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(4):536-41.
1990: Minamisawa H; Mellergård P; Smith M L; Bengtsson F; Theander S; Boris-Möller F; Siesjö B K
Preservation of brain temperature during ischemia in rats.
Stroke; a journal of cerebral circulation 1990;21(5):758-64.
1990: Minamisawa H; Nordström C H; Smith M L; Siesjö B K
The influence of mild body and brain hypothermia on ischemic brain damage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(3):365-74.
1990: Lundgren J; Mans A; Siesjö B K
Ischemia in normoglycemic and hyperglycemic rats: plasma energy substrates and hormones.
The American journal of physiology 1990;258(5 Pt 1):E767-74.
1990: Inamura K; Martins E; Themner K; Tapper S; Pallon J; Lövestam G; Malmqvist K G; Siesjö B K
Accumulation of calcium in substantia nigra lesions induced by status epilepticus. A microprobe analysis.
Brain research 1990;514(1):49-54.
1990: Bengtsson F; Boris-Möller F; Hansen A J; Siesjö B K
Extracellular pH in the rat brain during hypoglycemic coma and recovery.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(2):262-9.
1989: Folbergrová J; Smith M L; Inamura K; Siesjö B K
Decrease of glutamate decarboxylase activity in substantia nigra and caudoputamen following transient hyperglycemic ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(6):897-901.
1989: Inamura K; Smith M L; Hansen A J; Siesjö B K
Seizure-induced damage to substantia nigra and globus pallidus is accompanied by pronounced intra- and extracellular acidosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(6):821-9.
1989: Mellergård P; Bengtsson F; Smith M L; Riesenfeld V; Siesjö B K
Time course of early brain edema following reversible forebrain ischemia in rats.
Stroke; a journal of cerebral circulation 1989;20(11):1565-70.
1989: Kozuka M; Smith M L; Siesjö B K
Preischemic hyperglycemia enhances postischemic depression of cerebral metabolic rate.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(4):478-90.
1989: Siesjö B K; Bengtsson F
Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(2):127-40.
1989: Rehncrona S; Hauge H N; Siesjö B K
Enhancement of iron-catalyzed free radical formation by acidosis in brain homogenates: differences in effect by lactic acid and CO2.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(1):65-70.
1989: Siesjö B K; Agardh C D; Bengtsson F; Smith M L
Arachidonic acid metabolism in seizures.
Annals of the New York Academy of Sciences 1989;559():323-39.
1989: Siesjö B K; Bengtsson F; Grampp W; Theander S
Calcium, excitotoxins, and neuronal death in the brain.
Annals of the New York Academy of Sciences 1989;568():234-51.
1988: Siesjö B K
Mechanisms of ischemic brain damage.
Critical care medicine 1988;16(10):954-63.
1988: Malmqvist K G; Brun A; Inamura K; Martins E; Salford L G; Siesjö B K; Tapper U A; Themner K
Proton microprobe and particle induced X-ray emission (PIXE) analysis for studies of pathological brain tissue.
Scanning microscopy 1988;2(3):1685-93.
1988: Martins E; Inamura K; Themner K; Malmqvist K G; Siesjö B K
Accumulation of calcium and loss of potassium in the hippocampus following transient cerebral ischemia: a proton microprobe study.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1988;8(4):531-8.
1988: Siesjö B K
Acidosis and ischemic brain damage.
Neurochemical pathology 1988;9():31-88.
1988: Inamura K; Smith M L; Olsson Y; Siesjö B K
Pathogenesis of substantia nigra lesions following hyperglycemic ischemia: changes in energy metabolites, cerebral blood flow, and morphology of pars reticulata in a rat model of ischemia.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1988;8(3):375-84.
1988: Smith M L; Kalimo H; Warner D S; Siesjö B K
Morphological lesions in the brain preceding the development of postischemic seizures.
Acta neuropathologica 1988;76(3):253-64.
1988: Siesjö B K
Historical overview. Calcium, ischemia, and death of brain cells.
Annals of the New York Academy of Sciences 1988;522():638-61.
1987: Siesjö B K; Deshpande J K
Electrolyte shifts between brain and plasma in hypoglycemic coma.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1987;7(6):789-93.
1987: Inamura K; Olsson Y; Siesjö B K
Substantia nigra damage induced by ischemia in hyperglycemic rats. A light and electron microscopic study.
Acta neuropathologica 1987;75(2):131-9.

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