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Helmut Sigel

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
11
Griesser, Rolf
8
Holý, Antonín
7
Lippert, Bernhard
7
Kapinos, Larisa
7
Knobloch, Bernd
6
Da Costa, Carla
6
Gómez-Coca, Raquel
5
Okruszek, Andrzej
5
Operschall, Bert
5
Song, Bin
4
Vilaplana, Rosario
4
González-Vílchez, Francisco
4
Fernández-Botello, Alfonso
3
Lüth, Marc Sven
3
Massoud, Salah

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Publications

TOP 3
Sigel Helmut; Operschall Bert P; Griesser Rolf
Xanthosine 5'-monophosphate (XMP). Acid-base and metal ion-binding properties of a chameleon-like nucleotide.
Knobloch Bernd; Okruszek Andrzej; Sigel Helmut
Inosylyl(3'-->5')inosine (IpI-). Acid-base and metal ion-binding properties of a dinucleoside monophosphate in aqueous solution.
Freisinger Eva; Griesser Rolf; Lippert Bernhard; Moreno-Luque Cristóbal F; Niclós-Gutiérrez Juan; Ochocki Justyn; Operschall Bert P; Sigel Helmut
Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa).

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All Publications

2009: Sigel Helmut; Operschall Bert P; Griesser Rolf
Xanthosine 5'-monophosphate (XMP). Acid-base and metal ion-binding properties of a chameleon-like nucleotide.
Chemical Society reviews 2009;38(8):2465-94.
2008: Knobloch Bernd; Okruszek Andrzej; Sigel Helmut
Inosylyl(3'-->5')inosine (IpI-). Acid-base and metal ion-binding properties of a dinucleoside monophosphate in aqueous solution.
Inorganic chemistry 2008;47(7):2641-8.
2008: Freisinger Eva; Griesser Rolf; Lippert Bernhard; Moreno-Luque Cristóbal F; Niclós-Gutiérrez Juan; Ochocki Justyn; Operschall Bert P; Sigel Helmut
Comparison of the surprising metal-ion-binding properties of 5- and 6-uracilmethylphosphonate (5Umpa2- and 6Umpa2-) in aqueous solution and crystal structures of the dimethyl and di(isopropyl) esters of H2(6Umpa).
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(32):10036-46.
2007: Odani Akira; Kozlowski Henryk; Swiatek-Kozlowska Jolanta; Brasun Justyna; Operschall Bert P; Sigel Helmut
Extent of metal ion-sulfur binding in complexes of thiouracil nucleosides and nucleotides in aqueous solution.
Journal of inorganic biochemistry 2007;101(4):727-35.
2007: Knobloch Bernd; Sigel Helmut; Okruszek Andrzej; Sigel Roland K O
Metal-ion-coordinating properties of the dinucleotide 2'-deoxyguanylyl(5'-->3')-2'-deoxy-5'-guanylate (d(pGpG)3-): isomeric equilibria including macrochelated complexes relevant for nucleic acids.
Chemistry (Weinheim an der Bergstrasse, Germany) 2007;13(6):1804-14.
2006: Sigel Helmut; Operschall Bert P; Massoud Salah S; Song Bin; Griesser Rolf
Evidence for intramolecular aromatic-ring stacking in the physiological pH range of the monodeprotonated xanthine residue in mixed-ligand complexes containing xanthosinate 5'-monophosphate (XMP).
Dalton transactions (Cambridge, England : 2003) 2006;(46):5521-9.
2006: Sigel Helmut; Massoud Salah S; Song Bin; Griesser Rolf; Knobloch Bernd; Operschall Bert P
Acid-base and metal-ion-binding properties of xanthosine 5'-monophosphate (XMP) in aqueous solution: complex stabilities, isomeric equilibria, and extent of macrochelation.
Chemistry (Weinheim an der Bergstrasse, Germany) 2006;12(31):8106-22.
2006: Knobloch Bernd; Sigel Helmut; Okruszek Andrzej; Sigel Roland K O
Acid-base properties of the nucleic-acid model 2'-deoxyguanylyl(5'-->3')-2'-deoxy-5'-guanylate, d(pGpG)3-, and of related guanine derivatives.
Organic & biomolecular chemistry 2006;4(6):1085-90.
2005: Sigel Helmut; Griesser Rolf
Nucleoside 5'-triphosphates: self-association, acid-base, and metal ion-binding properties in solution.
Chemical Society reviews 2005;34(10):875-900.
2005: Fernández-Botello Alfonso; Griesser Rolf; Holý Antonín; Moreno Virtudes; Sigel Helmut
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in solution.
Inorganic chemistry 2005;44(14):5104-17.
2005: Knobloch Bernd; Linert Wolfgang; Sigel Helmut
Metal ion-binding properties of (N3)-deprotonated uridine, thymidine, and related pyrimidine nucleosides in aqueous solution.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7459-64.
2004: Fernández-Botello Alfonso; Holý Antonín; Moreno Virtudes; Sigel Helmut
Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine.
Journal of inorganic biochemistry 2004;98(12):2114-24.
2004: Gómez-Coca Raquel B; Kapinos Larisa E; Holý Antonín; Vilaplana Rosario A; González-Vílchez Francisco; Sigel Helmut
Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(8):961-72.
2004: Massoud Salah S; Corfù Nicolas A; Griesser Rolf; Sigel Helmut
Acid-base properties of xanthosine 5'-monophosphate (XMP) and of some related nucleobase derivatives in aqueous solution: micro acidity constant evaluations of the (N1)H versus the (N3)H deprotonation ambiguity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(20):5129-37.
2004: Knobloch Bernd; Sigel Roland K O; Lippert Bernhard; Sigel Helmut
Two metal ions coordinated to a purine residue tolerate each other well.
Angewandte Chemie (International ed. in English) 2004;43(29):3793-5.
2004: Knobloch Bernd; Sigel Helmut
A quantitative appraisal of the ambivalent metal ion binding properties of cytidine in aqueous solution and an estimation of the anti-syn energy barrier of cytidine derivatives.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2004;9(3):365-73.
2004: Sigel Helmut
Metal ion complexes of antivirally active nucleotide analogues. Conclusions regarding their biological action.
Chemical Society reviews 2004;33(3):191-200.
2004: Garijo Añorbe Marta; Lüth Marc Sven; Roitzsch Michael; Morell Cerdà Marta; Lax Patrick; Kampf Gunnar; Sigel Helmut; Lippert Bernhard
Perturbation of the NH2 pKa value of adenine in platinum(II) complexes: distinct stereochemical internucleobase effects.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(4):1046-57.
2004: Sánchez-Moreno María José; Fernández-Botello Alfonso; Gómez-Coca Raquel B; Griesser Rolf; Ochocki Justyn; Kotynski Andrzej; Niclós-Gutiérrez Juan; Moreno Virtudes; Sigel Helmut
Metal ion-binding properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-) in aqueous solution. Isomeric equilibria, extent of chelation, and a new quantification method for the chelate effect.
Inorganic chemistry 2004;43(4):1311-22.
2004: Gómez-Coca Raquel B; Holý Antonín; Vilaplana Rosario A; González-Vílchez Francisco; Sigel Helmut
Nickel(II), Copper(II) and Zinc(II) Complexes of 9-[2- (Phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA), the 8-Aza Derivative of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)ethyl] adenine (PMEA). Quantification of Four Isomeric Species in Aqueous Solution.
Bioinorganic chemistry and applications 2004;():331-52.
2003: Da Costa Carla P; Okruszek Andrzej; Sigel Helmut
Complex formation of divalent metal ions with uridine 5'-O-thiomonophosphate or methyl thiophosphate: comparison of complex stabilities with those of the parent phosphate ligands.
Chembiochem : a European journal of chemical biology 2003;4(7):593-602.
2003: Da Costa Carla P; Sigel Helmut
Acid-base and metal ion binding properties of guanylyl(3'-->5')guanosine (GpG-) and 2'-deoxyguanylyl(3'-->5')-2'-deoxyguanosine [d(GpG)-] in aqueous solution.
Inorganic chemistry 2003;42(11):3475-82.
2003: Sánchez-Moreno María José; Gómez-Coca Raquel B; Fernández-Botello Alfonso; Ochocki Justyn; Kotynski Andrzej; Griesser Rolf; Sigel Helmut
Synthesis and acid-base properties of (1H-benzimidazol-2-yl-methyl)phosphonate (Bimp2-). Evidence for intramolecular hydrogen-bond formation in aqueous solution between (N-1)H and the phosphonate group.
Organic & biomolecular chemistry 2003;1(10):1819-26.
2003: Bianchi Emanuela M; Sajadi S Ali A; Song Bin; Sigel Helmut
Stabilities and isomeric equilibria in aqueous solution of monomeric metal ion complexes of adenosine 5'-diphosphate (ADP3-) in comparison with those of adenosine 5'-monophosphate (AMP2-).
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(4):881-92.
2003: Griesser Rolf; Kampf Gunnar; Kapinos Larisa E; Komeda Seiji; Lippert Bernhard; Reedijk Jan; Sigel Helmut
Intrinsic acid-base properties of purine derivatives in aqueous solution and comparison of the acidifying effects of platinum(II) coordinated to N1 or N7: acidifying effects are reciprocal and the proton "outruns" divalent metal ions.
Inorganic chemistry 2003;42(1):32-41.
2002: Da Costa Carla P; Krajewska Danuta; Okruszek Andrzej; Stec Wojciech J; Sigel Helmut
Stabilities of lead(II) complexes formed in aqueous solution with methyl thiophosphate (MeOPS(2-)), uridine 5'- O-thiomonophosphate (UMPS(2-)) or adenosine 5'- O-thiomonophosphate (AMPS(2-)).
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(4-5):405-15.
2001: Sigel H; Bianchi E M; Corfù N A; Kinjo Y; Tribolet R; Martin R B
Stabilities and isomeric equilibria in solutions of monomeric metal-ion complexes of guanosine 5'-triphosphate (GTP4-) and inosine 5'-triphosphate (ITP4-) in comparison with those of adenosine 5'-triphosphate (ATP4-).
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(17):3729-37.
2001: Kampf G; Lüth M S; Kapinos L E; Müller J; Holý A; Lippert B; Sigel H
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.
Chemistry (Weinheim an der Bergstrasse, Germany) 2001;7(9):1899-908.
2001: Kapinos L E; Holý A; Günter J; Sigel H
Metal ion-binding properties of 1-methyl-4-aminobenzimidazole (=9-methyl-1,3-dideazaadenine) and 1,4-dimethylbenzimidazole (=6,9-dimethyl-1,3-dideazapurine). quantification of the steric effect of the 6-amino group on metal ion binding at the N7 site of the adenine residue.
Inorganic chemistry 2001;40(11):2500-8.
2001: Gómez-Coca R B; Kapinos L E; Holý A; Vilaplana R A; González-Vílchez F; Sigel H
Intramolecular stacking interactions in ternary copper(II) complexes formed with 2,2'-bipyridine or 1,10-phenanthroline and 9-(4-phosphonobutyl)adenine (dPMEA), the carba relative of the antiviral nucleotide analogue 9.
Journal of inorganic biochemistry 2001;84(1-2):39-46.
2000: Da Costa C P; Sigel H
Lead(II)-binding properties of the 5'-monophosphates of adenosine (AMP2-), inosine (IMP2-), and guanosine (GMP2-) in aqueous solution. Evidence for nucleobase-lead(II) interactions.
Inorganic chemistry 2000;39(26):5985-93.
2000: Sigel H; Da Costa C P
Metal ion-carbonyl oxygen recognition in complexes of acetyl phosphate.
Journal of inorganic biochemistry 2000;79(1-4):247-51.
2000: Lüth M S; Song B; Lippert B; Sigel H
Isomeric equilibria in aqueous solution involving aromatic ring stacking in the sexternary complexes formed by the quaternary cis-(NH3)2Pt(2'-deoxyguanosine-N7)(dGMP-N7) complex and the binary Cu(2,2'-bipyridine)2+ or Cu(1,10-phenanthroline)2+ complexes (dGMP2- = 2'-deoxyguanosine 5'-monophosphate).
Inorganic chemistry 2000;39(6):1305-10.
2000: Sigel H; Saha A; Saha N; Carloni P; Kapinos L E; Griesser R
Evaluation of intramolecular equilibria in complexes formed between substituted imidazole ligands and nickel (II), copper (II) or zinc (II).
Journal of inorganic biochemistry 2000;78(2):129-37.
2000: Gómez-Coca R B; Kapinos L E; Holý A; Vilaplana R A; González-Vílchez F; Sigel H
Ternary Copper(II) Complexes in Solution Formed With 8-Aza Derivatives of the Antiviral Nucleotide Analogue 9-[2-(Phosphonomethoxy)Ethyl]Adenine (PMEA).
Metal-based drugs 2000;7(6):313-24.
1999: Da Costa C P; Sigel H
Stabilities of complexes formed between lead(II) and simple phosphonate or phosphate monoester ligands including some pyrimidine-nucleoside 5'-monophosphates (CMP2-, UMP2-, dTMP2-).
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 1999;4(4):508-14.
1999: Song B; Zhao J; Gregán F; Prónayová N; Sajadi S A; Sigel H
Metal ion-binding properties of the diphosphate ester analogue, methylphosphonylphosphate, in aqueous solution.
Metal-based drugs 1999;6(6):321-8.
1997: Bastian M; Sigel H
The self-association of flavin mononucleotide (FMN(2-)) as determined by (1)H NMR shift measurements.
Biophysical chemistry 1997;67(1-3):27-34.
1996: Song B; Oswald G; Bastian M; Sigel H; Lippert B
Extent of the Acidification by N7-Coordinated cis-Diammine-Platinum(II) on the Acidic Sites of Guanine Derivatives.
Metal-based drugs 1996;3(3):131-41.

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