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David Sigman

Research Profile

Chemicals & Drugs

Concepts & Ideas

Physiology

Transcription, Genetic

Living Beings

Escherichia coli

Genes & Molecular Sequences

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Publications

TOP 3
Jae-Taeg Hwang; Francis E Baltasar; Daniel L Cole; David S Sigman; Chi-Hong B Chen; Marc M Greenberg
Transcription inhibition using modified pentanucleotides.
Gaoping Xiao; Daniel L Cole; Robert P Gunsalus; David S Sigman; Chi-Hong B Chen
Site-specific DNA cleavage of synthetic NarL sites by an engineered Escherichia coli NarL protein-1,10-phenanthroline cleaving agent.
C B Chen; Lisa Milne; Ralf Landgraf; DM Perrin; David S Sigman
Artificial nucleases.

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All Publications

2003: Jae-Taeg Hwang; Francis E Baltasar; Daniel L Cole; David S Sigman; Chi-Hong B Chen; Marc M Greenberg
Transcription inhibition using modified pentanucleotides.
Bioorganic & medicinal chemistry 2003;11(10):2321-8.
2002: Gaoping Xiao; Daniel L Cole; Robert P Gunsalus; David S Sigman; Chi-Hong B Chen
Site-specific DNA cleavage of synthetic NarL sites by an engineered Escherichia coli NarL protein-1,10-phenanthroline cleaving agent.
Protein science : a publication of the Protein Society 2002;11(10):2427-36.
2001: C B Chen; Lisa Milne; Ralf Landgraf; DM Perrin; David S Sigman
Artificial nucleases.
Chembiochem : a European journal of chemical biology 2001;2(10):735-40.
2001: Lisa Milne; DM Perrin; David S Sigman
Oligoribonucleotide-based gene-specific transcription inhibitors that target the open complex.
Methods (San Diego, Calif.) 2001;23(2):160-8.
2000: Lisa Milne; Y Xu; DM Perrin; David S Sigman
An approach to gene-specific transcription inhibition using oligonucleotides complementary to the template strand of the open complex.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3136-41.
1998: Chi-Hong B Chen; Ralf Landgraf; A D Walts; L Chan; P M Schlonk; T C Terwilliger; David S Sigman
Scission of DNA at a preselected sequence using a single-strand-specific chemical nuclease.
Chemistry & biology 1998;5(5):283-92.
1998: J Gallagher; O Zelenko; A D Walts; David S Sigman
Protease activity of 1,10-phenanthroline-copper(I). Targeted scission of the catalytic site of carbonic anhydrase.
Biochemistry 1998;37(8):2096-104.
1996: C Q Pan; S E Finkel; S E Cramton; J A Feng; David S Sigman; Reid C Johnson
Variable structures of Fis-DNA complexes determined by flanking DNA-protein contacts.
Journal of molecular biology 1996;264(4):675-95.
1996: J Gallagher; D M Perrin; L Chan; E Kwong; David S Sigman
Recognition of tetrahedral 1,10-phenanthroline-cuprous chelates by transcriptionally active complexes does not depend on the sequence of the promoter.
Chemistry & biology 1996;3(9):739-46.
1996: Ralf Landgraf; K S Ramamurthi; David S Sigman
Kinetics of spontaneous displacement of RNA from heteroduplexes by DNA.
Nucleic acids research 1996;24(16):3246-52.
1996: J Gallagher; C H Chen; C Q Pan; D M Perrin; Y M Cho; David S Sigman
Optimizing the targeted chemical nuclease activity of 1,10-phenanthroline-copper by ligand modification.
Bioconjugate chemistry 1996;7(4):413-20.
1996: Ralf Landgraf; C Pan; C Sutton; L Pearson; David S Sigman
Engineering of DNA binding proteins into site-specific cutters: reactivity of Trp repressor-1,10-phenanthroline chimeras.
Protein engineering 1996;9(7):603-10.
1996: D M Perrin; V M Hoang; Y Xu; A Mazumder; David S Sigman
Inhibitors of Escherichia coli RNA polymerase specific for the single-stranded DNA of transcription intermediates. Tetrahedral cuprous chelates of 1,10-phenanthrolines.
Biochemistry 1996;35(16):5318-26.
1996: C Q Pan; Reid C Johnson; David S Sigman
Identification of new Fis binding sites by DNA scission with Fis-1,10-phenanthroline-copper(I) chimeras.
Biochemistry 1996;35(14):4326-33.
1996: D M Perrin; A Mazumder; David S Sigman
Oxidative chemical nucleases.
Progress in nucleic acid research and molecular biology 1996;52():123-51.
1996: David S Sigman; Ralf Landgraf; D M Perrin; L Pearson
Nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives.
Metal ions in biological systems 1996;33():485-513.
1995: C Q Pan; Ralf Landgraf; David S Sigman
Drosophila engrailed-1,10-phenanthroline chimeras as probes of homeodomain-DNA complexes.
Protein science : a publication of the Protein Society 1995;4(11):2279-88.
1995: Jian Wu; D M Perrin; David S Sigman; H Ronald Kaback
Helix packing of lactose permease in Escherichia coli studied by site-directed chemical cleavage.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(20):9186-90.
1995: Ralf Landgraf; C H Chen; David S Sigman
Double stranded scission of DNA directed through sequence-specific R-loop formation.
Nucleic acids research 1995;23(17):3524-30.
1995: Ralf Landgraf; C H Chen; David S Sigman
R-loop stability as a function of RNA structure and size.
Nucleic acids research 1995;23(17):3516-23.
1995: A Mazumder; M Gupta; D M Perrin; David S Sigman; M Rabinovitz; Yves Pommier
Inhibition of human immunodeficiency virus type 1 integrase by a hydrophobic cation: the phenanthroline-cuprous complex.
AIDS research and human retroviruses 1995;11(1):115-25.
1994: D M Perrin; L Pearson; A Mazumder; David S Sigman
Inhibition of prokaryotic and eukaryotic transcription by the 2:1 2,9-dimethyl-1,10-phenanthroline-cuprous complex, a ligand specific for open complexes.
Gene 1994;149(1):173-8.
1994: Ralf Landgraf; C H Chen; David S Sigman
Oligonucleotide-directed nucleic acid scission by micrococcal nuclease.
Biochemistry 1994;33(35):10607-15.
1994: L Pearson; C B Chen; R P Gaynor; David S Sigman
Footprinting RNA-protein complexes following gel retardation assays: application to the R-17-procoat-RNA and tat--TAR interactions.
Nucleic acids research 1994;22(12):2255-63.
1994: C Q Pan; Ralf Landgraf; David S Sigman
DNA-binding proteins as site-specific nucleases.
Molecular microbiology 1994;12(3):335-42.
1994: D M Perrin; A Mazumder; F Sadeghi; David S Sigman
Hybridization of a complementary ribooligonucleotide to the transcription start site of the lacUV-5-Escherichia coli RNA polymerase open complex. Potential for gene-specific inactivation reagents.
Biochemistry 1994;33(13):3848-54.
1994: C Q Pan; J A Feng; S E Finkel; Ralf Landgraf; David S Sigman; Reid C Johnson
Structure of the Escherichia coli Fis-DNA complex probed by protein conjugated with 1,10-phenanthroline copper(I) complex.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(5):1721-5.
1994: A Mazumder; D M Perrin; D McMillin; David S Sigman
Interactions of transcription inhibitors with the Escherichia coli RNA polymerase-lacUV5 promoter open complex.
Biochemistry 1994;33(8):2262-8.
1993: A Mazumder; D M Perrin; K J Watson; David S Sigman
A transcription inhibitor specific for unwound DNA in RNA polymerase-promoter open complexes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):8140-4.
1993: David S Sigman; C H Chen; M B Gorin
Sequence-specific scission of DNA by RNAs linked to a chemical nuclease.
Nature 1993;363(6428):474-5.
1993: C B Chen; M B Gorin; David S Sigman
Sequence-specific scission of DNA by the chemical nuclease activity of 1,10-phenanthroline-copper(I) targeted by RNA.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):4206-10.
1993: C L Sutton; A Mazumder; C H Chen; David S Sigman
Transforming the Escherichia coli Trp repressor into a site-specific nuclease.
Biochemistry 1993;32(16):4225-30.
1993: C H Chen; A Mazumder; J F Constant; David S Sigman
Nuclease activity of 1,10-phenanthroline-copper. New conjugates with low molecular weight targeting ligands.
Bioconjugate chemistry 1993;4(1):69-77.
1992: A Mazumder; C B Chen; R Gaynor; David S Sigman
1,10-Phenanthroline-copper, a footprinting reagent for single-stranded regions of RNAs.
Biochemical and biophysical research communications 1992;187(3):1503-9.
1991: F Wu; J Garcia; David S Sigman; R Gaynor
tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.
Genes & development 1991;5(11):2128-40.
1991: Herbert Avila; David S Sigman; L M Cohen; R C Millikan; Larry Simpson
Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: diagnosis of chronic Chagas' disease.
Molecular and biochemical parasitology 1991;48(2):211-21.
1991: David S Sigman; M D Kuwabara; C H Chen; T W Bruice
Nuclease activity of 1,10-phenanthroline-copper in study of protein-DNA interactions.
Methods in enzymology 1991;208():414-33.
1990: David S Sigman
Chemical nucleases.
Biochemistry 1990;29(39):9097-105.
1990: T Thederahn; A Spassky; M D Kuwabara; David S Sigman
Chemical nuclease activity of 5-phenyl-1,10-phenanthroline-copper ion detects intermediates in transcription initiation by E. Coli RNA polymerase.
Biochemical and biophysical research communications 1990;168(2):756-62.
1990: C Yoon; M D Kuwabara; A Spassky; David S Sigman
Sequence specificity of the deoxyribonuclease activity of 1,10-phenanthroline-copper ion.
Biochemistry 1990;29(8):2116-21.
1990: David S Sigman; C H Chen
Chemical nucleases: new reagents in molecular biology.
Annual review of biochemistry 1990;59():207-36.
1989: G G Hermanson; M Briskin; David S Sigman; Randolph Wall
Immunoglobulin enhancer and promoter motifs 5' of the B29 B-cell-specific gene.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7341-5.
1989: George J Murakawa; C H Chen; M D Kuwabara; D P Nierlich; David S Sigman
Scission of RNA by the chemical nuclease of 1,10-phenanthroline-copper ion: preference for single-stranded loops.
Nucleic acids research 1989;17(13):5361-75.
1989: Richard B Gaynor; E Soultanakis; M Kuwabara; J Garcia; David S Sigman
Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4858-62.
1988: Richard B Gaynor; M D Kuwabara; F K Wu; J A Garcia; David Harrich; M Briskin; Randolph Wall; David S Sigman
Repeated B motifs in the human immunodeficiency virus type I long terminal repeat enhancer region do not exhibit cooperative factor binding.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9406-10.
1988: M Briskin; M D Kuwabara; David S Sigman; Randolph Wall
Induction of kappa transcription by interferon-gamma without activation of NF-kappa B.
Science (New York, N.Y.) 1988;242(4881):1036-7.
1988: Andrew L Feig; T Thederahn; David S Sigman
Mutagenicity of the nuclease activity of 1,10-phenanthroline-copper ion.
Biochemical and biophysical research communications 1988;155(1):338-43.
1988: C Yoon; M D Kuwabara; R Law; Randolph Wall; David S Sigman
Sequence-dependent variability of DNA structure. Influence of flanking sequences and fragment length on digestion by conformationally sensitive nucleases.
The Journal of biological chemistry 1988;263(17):8458-63.
1987: R Law; M D Kuwabara; M Briskin; Nicolas Fasel; G Hermanson; David S Sigman; Randolph Wall
Protein-binding site at the immunoglobulin mu membrane polyadenylylation signal: possible role in transcription termination.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(24):9160-4.
1987: M D Kuwabara; David S Sigman
Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10-phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes.
Biochemistry 1987;26(23):7234-8.
1986: M Kuwabara; C Yoon; T Goyne; T Thederahn; David S Sigman
Nuclease activity of 1,10-phenanthroline-copper ion: reaction with CGCGAATTCGCG and its complexes with netropsin and EcoRI.
Biochemistry 1986;25(23):7401-8.
1985: A Spassky; David S Sigman
Nuclease activity of 1,10-phenanthroline-copper ion. Conformational analysis and footprinting of the lac operon.
Biochemistry 1985;24(27):8050-6.
1985: David S Sigman; A Spassky; Sylvie Rimsky; Henri Buc
Conformational analysis of lac promoters using the nuclease activity of 1,10-phenanthroline-copper ion.
Biopolymers 1985;24(1):183-97.