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Jennifer Sigmond

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Jennifer Sigmond; André Bergman; Leticia G Leon; Willem J P Loves; Eveline K Hoebe; Godefridus J Peters
Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.
Elisa Giovannetti; Richard Honeywell; Axel R Hanauske; Christina Tekle; Bart Kuenen; Jennifer Sigmond; Giuseppe Giaccone; Godefridus J Peters
Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).
C Tekle; Elisa Giovannetti; Jennifer Sigmond; J R Graff; Kees Smid; Godefridus J Peters
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.

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2010: Jennifer Sigmond; André Bergman; Leticia G Leon; Willem J P Loves; Eveline K Hoebe; Godefridus J Peters
Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.
Anti-cancer drugs 2010;21(6):591-9.
2010: Elisa Giovannetti; Richard Honeywell; Axel R Hanauske; Christina Tekle; Bart Kuenen; Jennifer Sigmond; Giuseppe Giaccone; Godefridus J Peters
Pharmacological aspects of the enzastaurin-pemetrexed combination in non-small cell lung cancer (NSCLC).
Current drug targets 2010;11(1):12-28.
2008: C Tekle; Elisa Giovannetti; Jennifer Sigmond; J R Graff; Kees Smid; Godefridus J Peters
Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells.
British journal of cancer 2008;99(5):750-9.
2007: Jennifer Sigmond; J A E Kamphuis; Adrie C Laan; Eveline K Hoebe; André Bergman; Godefridus J Peters
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent.
Biochemical pharmacology 2007;73(10):1548-57.
2006: Jaap Haveman; Jennifer Sigmond; Chris van Bree; N A P Franken; C Koedooder; Godefridus J Peters
Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation.
Oncology reports 2006;16(4):901-5.
2006: Jennifer Sigmond; Jaap Haveman; N Castro Kreder; Willem J P Loves; Chris van Bree; N A P Franken; Godefridus J Peters
Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1177-80.
2005: Isabelle Hubeek; Godefridus J Peters; A J F Broekhuizen; Iannis Talianidis; Jennifer Sigmond; Brenda E S Gibson; Ursula Creutzig; G Giaccone; G J L Kaspers
Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours.
Journal of clinical pathology 2005;58(7):695-9.
2005: Jennifer Sigmond; Godefridus J Peters
Pyrimidine and purine analogues, effects on cell cycle regulation and the role of cell cycle inhibitors to enhance their cytotoxicity.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1997-2022.
2004: Jennifer Sigmond; Elizabeth M Comijn; J A E Kamphuis; Godefridus J Peters
Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1503-6.
2004: Jennifer Sigmond; Willem J P Loves; Judith R Kroep; Godefridus J Peters
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR; in relation to enzyme activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1347-50.
2004: Jennifer Sigmond; Judith R Kroep; Willem J P Loves; Giovanni Codacci-Pisanelli; Godefridus J Peters
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.
Cancer letters 2004;213(2):173-9.
2003: Jennifer Sigmond; Harold H J Backus; Dorine Wouters; Olaf H Temmink; Gerrit Jansen; Godefridus J Peters
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Biochemical pharmacology 2003;66(3):431-8.