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Curt Sigmund

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Curt D Sigmund
A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system.
Yi Chu; Hardik Doshi; Georges P Hajj; Donald D Lund; Curt D Sigmund; Robert M Weiss; Robert M Brooks; Donald D Heistad
Pioglitazone attenuates valvular calcification induced by hypercholesterolemia.
Aline M Hilzendeger; Allyn L Mark; Martin D Cassell; Deborah R Davis; Justin L Grobe; Harald M Stauss; Curt D Sigmund
Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension.

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All Publications

2013: Curt D Sigmund
A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(4):676-8.
2013: Yi Chu; Hardik Doshi; Georges P Hajj; Donald D Lund; Curt D Sigmund; Robert M Weiss; Robert M Brooks; Donald D Heistad
Pioglitazone attenuates valvular calcification induced by hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(3):523-32.
2013: Aline M Hilzendeger; Allyn L Mark; Martin D Cassell; Deborah R Davis; Justin L Grobe; Harald M Stauss; Curt D Sigmund
Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension.
Hypertension 2013;61(3):716-22.
2013: Frederick W Quelle; Curt D Sigmund
PPARγ: no SirT, no service.
Circulation research 2013;112(3):411-4.
2013: Justin L Grobe; Xuebo Liu; Kamal Rahmouni; Curt D Sigmund
Metabolic rate regulation by the renin-angiotensin system: brain vs. body.
Pflügers Archiv : European journal of physiology 2013;465(1):167-75.
2012: Pimonrat Ketsawatsomkron; Xuebo Liu; Ramón A Lorca; Christopher J Pelham; Sarah K England; Frank M Faraci; Justin L Grobe; Henry L Keen; Eric T Weatherford; Curt D Sigmund
PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity.
Circulation research 2012;111(11):1446-58.
2012: Christopher J Pelham; Eric T Weatherford; Willem J de Lange; Frank M Faraci; Justin L Grobe; severine groh; Stella-Rita C Ibeawuchi; Henry L Keen; Pimonrat Ketsawatsomkron; Curt D Sigmund
Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.
Cell metabolism 2012;16(4):462-72.
2012: Aline M Hilzendeger; Xuebo Liu; Leonard Brooks; David Dellsperger; Justin L Grobe; Donald A Morgan; Kamal Rahmouni; Curt D Sigmund; Allyn L Mark
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity.
American journal of physiology. Heart and circulatory physiology 2012;303(2):H197-206.
2012: Sungmi Park; Deborah R Davis; Xuebo Liu; Curt D Sigmund
Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.
Hypertension 2012;59(6):1212-9.
2012: Mary L Modrick; Curt D Sigmund; Yi Chu; Dale A Kinzenbaw; Frank M Faraci
Peroxisome proliferator-activated receptor-γ protects against vascular aging.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;302(10):R1184-90.
2012: Eric T Weatherford; Xuebo Liu; Curt D Sigmund
Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6.
American journal of physiology. Renal physiology 2012;302(8):F1025-33.
2012: Curt D Sigmund
Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system.
American journal of physiology. Regulatory, integrative and comparative physiology 2012;302(3):R313-20.
2011: B Julie He; Stephane Heymans; Mei-Ling A Joiner; Olha M Koval; William Kutschke; Elizabeth D Luczak; Peter J Mohler; Curt D Sigmund; Madhu Singh; Douglas R Spitz; Paari Dominic Swaminathan; Robert M Weiss; Jinying Yang; Kathy Zimmerman; Chantal Allamargot; W Matthijs Blankesteijn; Isabella M Grumbach; Xiaoqun Guan; Mark E Anderson
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
Nature medicine 2011;17(12):1610-8.
2011: Huiping Li; Eric T Weatherford; Andrew M Allen; Lisa A Cassis; Alan Daugherty; Deborah R Davis; Justin L Grobe; Henry L Keen; Curt D Sigmund
Renal proximal tubule angiotensin AT1A receptors regulate blood pressure.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(4):R1067-77.
2011: Kamal Rahmouni; Robin L Davisson; Curt D Sigmund
Inflaming hypothalamic neurons raises blood pressure.
Cell metabolism 2011;14(1):3-4.
2011: Shannon M Harlan; Donald A Morgan; Khristofor Agassandian; Deng-Fu Guo; Martin D Cassell; Curt D Sigmund; Allyn L Mark; Kamal Rahmouni
Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation.
Circulation research 2011;108(7):808-12.
2011: Di Xu; Giulianna R Borges; Deborah R Davis; Khristofor Agassandian; Maria Luisa S Sequeira Lopez; R Ariel Gomez; Martin D Cassell; Justin L Grobe; Curt D Sigmund
Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism.
Physiological genomics 2011;43(6):286-94.
2011: Justin L Grobe; Beth A Buehrer; Aline M Hilzendeger; Xuebo Liu; Deborah R Davis; Di Xu; Curt D Sigmund
Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice.
Hypertension 2011;57(3):600-7.
2010: Curt D Sigmund
Structural biology: On stress and pressure.
Nature 2010;468(7320):46-7.
2010: Justin L Grobe; Connie L Grobe; Terry G Beltz; Scott G Westphal; Donald A Morgan; Di Xu; Willem J de Lange; Huiping Li; Koji Sakai; Daniel R Thedens; Lisa A Cassis; Kamal Rahmouni; Allyn L Mark; Alan Kim Johnson; Curt D Sigmund
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance.
Cell metabolism 2010;12(5):431-42.
2010: Justin L Grobe; Matthew E Dickson; Sungmi Park; Deborah R Davis; Ella J Born; Curt D Sigmund
Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice.
Hypertension 2010;56(5):981-7.
2010: Kenneth W Gross; R Ariel Gomez; Curt D Sigmund
Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin".
American journal of physiology. Regulatory, integrative and comparative physiology 2010;298(5):R1209-11.
2010: Pimonrat Ketsawatsomkron; Christopher J Pelham; severine groh; Henry L Keen; Frank M Faraci; Curt D Sigmund
Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?
The Journal of biological chemistry 2010;285(13):9311-6.
2010: Michael Desch; Andrea Schreiber; Frank Schweda; Kirsten Madsen; Ulla G Friis; Eric T Weatherford; Curt D Sigmund; Maria Luisa Sequeira Lopez; R Ariel Gomez; Vladimir T Todorov
Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
Hypertension 2010;55(3):660-6.
2010: Maria Luisa S Sequeira Lopez; Eric T Weatherford; Giulianna R Borges; Maria C Monteagudo; Ellen Steward Pentz; Brian D Harfe; Oscar Carretero; Curt D Sigmund; R Ariel Gomez
The microRNA-processing enzyme dicer maintains juxtaglomerular cells.
Journal of the American Society of Nephrology : JASN 2010;21(3):460-7.
2010: Henry L Keen; Carmen M Halabi; andreas beyer; Willem J de Lange; Xuebo Liu; Nobuyo Maeda; Frank M Faraci; Thomas L Casavant; Curt D Sigmund
Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):518-25.
2010: Yumei Feng; Huijing Xia; Yanhui Cai; Carmen M Halabi; Lenice K Becker; Robson Augusto Souza Santos; Robert C Speth; Curt D Sigmund; Eric Lazartigues
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension.
Circulation research 2010;106(2):373-82.
2010: Curt D Sigmund
Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency.
Hypertension 2010;55(2):437-44.
2010: Curt D Sigmund
Team exercise.
American journal of physiology. Regulatory, integrative and comparative physiology 2010;298(1):R1.
2009: Di Xu; Giulianna R Borges; Justin L Grobe; Christopher J Pelham; Baoli Yang; Curt D Sigmund
Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin.
Hypertension 2009;54(6):1240-7.
2009: Mark K Santillan; Donna A Santillan; Curt D Sigmund; Stephen K Hunter
From molecules to medicine: a future cure for preeclampsia?
Drug news & perspectives 2009;22(9):531-41.
2009: Robert A Bianco; Khristofor Agassandian; Martin D Cassell; Arthur A Spector; Curt D Sigmund
Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase.
Brain research 2009;1291():60-72.
2009: Hana Itani; Xuebo Liu; Ehab Sarsour; Prabhat C Goswami; Ella Born; Henry L Keen; Curt D Sigmund
Regulation of renin gene expression by oxidative stress.
Hypertension 2009;53(6):1070-6.
2009: Mary L Modrick; Sean P Didion; Curt D Sigmund; Frank M Faraci
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging.
American journal of physiology. Heart and circulatory physiology 2009;296(6):H1914-9.
2009: Kamal Rahmouni; Curt D Sigmund; William G Haynes; Allyn L Mark
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin.
Diabetes 2009;58(3):536-42.
2008: Curt D Sigmund
A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;295(6):R1846-8.
2008: Shannon M Harlan; Rebecca S Reiter; Curt D Sigmund; Jenny Li-Chun Lin; Jim Jung-Ching Lin
Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice.
Anatomical record (Hoboken, N.J. : 2007) 2008;291(12):1574-86.
2008: Matthew E Dickson; Xin Tian; Xuebo Liu; Deborah R Davis; Curt D Sigmund
Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism.
Circulation research 2008;103(9):940-7.
2008: Willem J de Lange; Carmen M Halabi; andreas beyer; Curt D Sigmund
Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles.
Physiological genomics 2008;35(1):1-4.
2008: Kamal Rahmouni; Curt D Sigmund
Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression.
Circulation research 2008;103(6):565-7.
2008: andreas beyer; Willem J de Lange; Carmen M Halabi; Mary L Modrick; Henry L Keen; Frank M Faraci; Curt D Sigmund
Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet.
Circulation research 2008;103(6):654-61.
2008: Xiyou Zhou; Eric T Weatherford; Xuebo Liu; Ella Born; Henry L Keen; Curt D Sigmund
Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus.
American journal of physiology. Renal physiology 2008;295(3):F642-53.
2008: Justin L Grobe; Di Xu; Curt D Sigmund
An intracellular renin-angiotensin system in neurons: fact, hypothesis, or fantasy.
Physiology (Bethesda, Md.) 2008;23():187-93.
2008: Peijun P Shi; Xiao R Cao; Eileen M Sweezer; Thomas S Kinney; Nathan R Williams; Russell F Husted; Ramesh Nair; Robert M Weiss; Roger A Williamson; Curt D Sigmund; Peter M Snyder; Olivier Staub; John B Stokes; Baoli Yang
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.
American journal of physiology. Renal physiology 2008;295(2):F462-70.
2008: Huiping Li; Xiyou Zhou; Deborah R Davis; Di Xu; Curt D Sigmund
An androgen-inducible proximal tubule-specific Cre recombinase transgenic model.
American journal of physiology. Renal physiology 2008;294(6):F1481-6.
2008: Yoshinobu Wakisaka; Jordan D Miller; Yi Chu; Gary L Baumbach; Saul Wilson; Frank M Faraci; Curt D Sigmund; Donald D Heistad
Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(6):1175-85.
2008: andreas beyer; Gary L Baumbach; Carmen M Halabi; Mary L Modrick; Cynthia M Lynch; Thomas D Gerhold; Shams M Ghoneim; Willem J de Lange; Henry L Keen; Yau-Sheng Tsai; Nobuyo Maeda; Curt D Sigmund; Frank M Faraci
Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling.
Hypertension 2008;51(4):867-71.
2008: Carmen M Halabi; andreas beyer; Willem J de Lange; Henry L Keen; Gary L Baumbach; Frank M Faraci; Curt D Sigmund
Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.
Cell metabolism 2008;7(3):215-26.
2008: Xiyou Zhou; Curt D Sigmund
Chorionic enhancer is dispensable for regulated expression of the human renin gene.
American journal of physiology. Regulatory, integrative and comparative physiology 2008;294(2):R279-87.
2007: Eric T Weatherford; Hana Itani; Henry L Keen; Curt D Sigmund
Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?
Hypertension 2007;50(5):844-6.
2007: Hiroyuki Kobori; Yuri Ozawa; Ryousuke Satou; Akemi Katsurada; Kayoko Miyata; Naro Ohashi; Naoki Hase; Yuki Suzaki; Curt D Sigmund; L Gabriel Navar
Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice.
American journal of physiology. Renal physiology 2007;293(3):F938-45.
2007: Ryan R Driskell; Michael Goodheart; Traci Neff; Xiaoming Liu; Meihui Luo; Chris Moothart; Curt D Sigmund; Ryoichi Hosokawa; Yang Chai; John F Engelhardt
Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.
Developmental biology 2007;305(1):90-102.
2007: Koji Sakai; Khristofor Agassandian; Satoshi Morimoto; Puspha Sinnayah; Martin D Cassell; Robin L Davisson; Curt D Sigmund
Local production of angiotensin II in the subfornical organ causes elevated drinking.
The Journal of clinical investigation 2007;117(4):1088-95.
2007: Matthew E Dickson; M Bridget Zimmerman; Kamal Rahmouni; Curt D Sigmund
The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells.
Hypertension 2007;49(3):631-9.
2007: Hana Itani; Xuebo Liu; J Howard Pratt; Curt D Sigmund
Functional characterization of polymorphisms in the kidney enhancer of the human renin gene.
Endocrinology 2007;148(3):1424-30.
2007: Paul B McCray; Lecia Pewe; Christine Wohlford-Lenane; Melissa Hickey; Lori J Manzel; Lei Shi; Jason Netland; Hong Peng Jia; Carmen Halabi; Curt D Sigmund; David K Meyerholz; Patricia A Kirby; Dwight C Look; Stanley Perlman
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.
Journal of virology 2007;81(2):813-21.
2006: Xuebo Liu; Qi Shi; Curt D Sigmund
Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells.
Endocrinology 2006;147(12):6011-8.
2006: Xiyou Zhou; Deborah R Davis; Curt D Sigmund
The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression.
The Journal of biological chemistry 2006;281(46):35296-304.
2006: Puspha Sinnayah; Eric Lazartigues; Koji Sakai; Ram V Sharma; Curt D Sigmund; Robin L Davisson
Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response.
Circulation research 2006;99(10):1125-31.
2006: Matthew E Dickson; Curt D Sigmund
Genetic basis of hypertension: revisiting angiotensinogen.
Hypertension 2006;48(1):14-20.
2006: X Renee Cao; P Peter Shi; Rita D Sigmund; Russell F Husted; Curt D Sigmund; Roger A Williamson; John B Stokes; Baoli Yang
Mice heterozygous for beta-ENaC deletion have defective potassium excretion.
American journal of physiology. Renal physiology 2006;291(1):F107-15.
2006: Marcus Brand; Noël Lamandé; Curt D Sigmund; Etienne Larger; Pierre Corvol; Jean-Marie Gasc
Angiotensinogen modulates renal vasculature growth.
Hypertension 2006;47(6):1067-74.
2006: Frank M Faraci; Kathryn G Lamping; Mary L Modrick; Michael J Ryan; Curt D Sigmund; Sean P Didion
Cerebral vascular effects of angiotensin II: new insights from genetic models.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2006;26(4):449-55.
2006: S Sachetelli; Q Liu; Shao-Ling Zhang; Fang Liu; Tusty-Jiuan Hsieh; ML Brezniceanu; Deng-Fu Guo; János G Filep; Julie R Ingelfinger; Curt D Sigmund; Pavel Hamet; John S D Chan
RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney.
Kidney international 2006;69(6):1016-23.
2006: Julie L Lavoie; Xuebo Liu; Robert A Bianco; Terry G Beltz; Alan Kim Johnson; Curt D Sigmund
Evidence supporting a functional role for intracellular renin in the brain.
Hypertension 2006;47(3):461-6.
2006: Sanjeev Sethi; Shinichiro Iida; Curt D Sigmund; Donald D Heistad
Renal thrombotic microangiopathy in a genetic model of hypertension in mice.
Experimental biology and medicine (Maywood, N.J.) 2006;231(2):196-203.
2006: Curt D Sigmund; Robin L Davisson
Targeting brain AT1 receptors by RNA interference.
Hypertension 2006;47(2):145-6.
2006: Péter J Kiss; Judit Knisz; Yuzhou Zhang; Jonas Baltrusaitis; Curt D Sigmund; Ruediger Thalmann; Richard J H Smith; Elisabeth Verpy; Botond Bánfi
Inactivation of NADPH oxidase organizer 1 results in severe imbalance.
Current biology : CB 2006;16(2):208-13.
2005: Mikhiela Sherrod; Deborah R Davis; Xizhou Zhou; Martin D Cassell; Curt D Sigmund
Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;289(6):R1763-9.
2005: Shinichiro Iida; Gary L Baumbach; Julie L Lavoie; Frank M Faraci; Curt D Sigmund; Donald D Heistad
Spontaneous stroke in a genetic model of hypertension in mice.
Stroke; a journal of cerebral circulation 2005;36(6):1253-8.
2005: Melissa A Fath; robert Mullins; Charles C Searby; Darryl Y Nishimura; Jun Wei; Kamal Rahmouni; Roger E Davis; Marwan K Tayeh; Michael Andrews; Baoli Yang; Curt D Sigmund; Edwin M Stone; Val C Sheffield
Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome.
Human molecular genetics 2005;14(9):1109-18.
2005: Koji Sakai; Curt D Sigmund
Molecular evidence of tissue renin-angiotensin systems: a focus on the brain.
Current hypertension reports 2005;7(2):135-40.
2005: Mikhiela Sherrod; Xuebo Liu; Xiaoji Zhang; Curt D Sigmund
Nuclear localization of angiotensinogen in astrocytes.
American journal of physiology. Regulatory, integrative and comparative physiology 2005;288(2):R539-46.
2005: Carmen M Halabi; Curt D Sigmund
Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2005;5(6):389-98.
2004: Koji Sakai; Mark W Chapleau; Satoshi Morimoto; Martin D Cassell; Curt D Sigmund
Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II.
Physiological genomics 2004;20(1):66-72.
2004: Gary L Baumbach; Curt D Sigmund; Frank M Faraci
Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase.
Circulation research 2004;95(8):822-9.
2004: Ryan R Driskell; Xiaoming Liu; Meihui Luo; Mohammed Filali; Weihong Zhou; Duane Abbott; Ningli Cheng; Chris Moothart; Curt D Sigmund; John F Engelhardt
Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L752-63.
2004: Kamal Rahmouni; Donald A Morgan; Gina M Morgan; Xuebo Liu; Curt D Sigmund; Allyn L Mark; William G Haynes
Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin.
The Journal of clinical investigation 2004;114(5):652-8.
2004: Laura L Stunz; Lisa K Busch; Melissa Munroe; Curt D Sigmund; Lorraine T Tygrett; Thomas J Waldschmidt; Gail A Bishop
Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture.
Immunity 2004;21(2):255-66.
2004: Julie L Lavoie; Robert A Bianco; K Sakai; Henry L Keen; Michael J Ryan; Curt D Sigmund
Transgenic mice for studies of the renin-angiotensin system in hypertension.
Acta physiologica Scandinavica 2004;181(4):571-7.
2004: Xiaoming Liu; Ryan R Driskell; Meihui Luo; Duane Abbott; Mohammed Filali; Ningli Cheng; Curt D Sigmund; John F Engelhardt
Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin.
The Journal of investigative dermatology 2004;123(2):264-74.
2004: Sanjana Dayal; Erland Arning; Teodoro Bottiglieri; Rainer H Böger; Curt D Sigmund; Frank M Faraci; Steven R Lentz
Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.
Stroke; a journal of cerebral circulation 2004;35(8):1957-62.
2004: Henry L Keen; Michael J Ryan; Andreas Beyer; Satya Mathur; Todd E Scheetz; Barry D Gackle; Frank M Faraci; Thomas L Casavant; Curt D Sigmund
Gene expression profiling of potential PPARgamma target genes in mouse aorta.
Physiological genomics 2004;18(1):33-42.
2004: Kamal Rahmouni; Allyn L Mark; William G Haynes; Curt D Sigmund
Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity.
American journal of physiology. Endocrinology and metabolism 2004;286(6):E891-5.
2004: Wei-Gen Li; Dan Gavrila; Xuebo Liu; Lixing Wang; Skuli Gunnlaugsson; Lynn L Stoll; Michael L McCormick; Curt D Sigmund; Chaosu Tang; Neal L Weintraub
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells.
Circulation 2004;109(18):2221-6.
2004: Julie L Lavoie; Kristy D Lake-Bruse; Curt D Sigmund
Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule.
American journal of physiology. Renal physiology 2004;286(5):F965-71.
2004: Julie L Lavoie; Martin D Cassell; Kenneth W Gross; Curt D Sigmund
Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model.
Hypertension 2004;43(5):1116-9.
2004: Michael J Ryan; Sean P Didion; Satya Mathur; Frank M Faraci; Curt D Sigmund
Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice.
Hypertension 2004;43(5):1074-9.
2004: Ravi Nistala; Xiaoji Zhang; Curt D Sigmund
Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice.
Physiological genomics 2004;17(1):4-10.
2004: John A Wemmie; Matthew W Coryell; Candice C Askwith; Ejvis Lamani; A Soren Leonard; Curt D Sigmund; Michael J Welsh
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3621-6.
2004: Michael J Ryan; Sean P Didion; Satya Mathur; Frank M Faraci; Curt D Sigmund
PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice.
Hypertension 2004;43(3):661-6.
2004: Xiuying Ma; Curt D Sigmund; Shawn D Hingtgen; Xin Tian; Robin L Davisson; Francois M Abboud; Mark W Chapleau
Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice.
Hypertension 2004;43(2):312-6.
2004: Julie L Lavoie; Martin D Cassell; Kenneth W Gross; Curt D Sigmund
Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model.
Physiological genomics 2004;16(2):240-6.
2004: Michael J Ryan; Curt D Sigmund
ACE, ACE inhibitors, and other JNK.
Circulation research 2004;94(1):1-3.
2003: Robert A Bianco; Henry L Keen; Julie L Lavoie; Curt D Sigmund
Untraditional methods for targeting the kidney in transgenic mice.
American journal of physiology. Renal physiology 2003;285(6):F1027-33.
2003: Chien-Chang Chen; Kathryn G Lamping; Daniel W Nuno; Rita Barresi; Sally J Prouty; Julie L Lavoie; Leanne L Cribbs; Sarah K England; Curt D Sigmund; Robert M Weiss; Roger A Williamson; James A Hill; Kevin P Campbell
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels.
Science (New York, N.Y.) 2003;302(5649):1416-8.
2003: Michael J Ryan; Curt D Sigmund
HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):1960-2.
2003: Julie L Lavoie; Curt D Sigmund
Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system.
Endocrinology 2003;144(6):2179-83.
2003: Xuebo Liu; Xiaodong Huang; Curt D Sigmund
Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription.
Circulation research 2003;92(9):1033-40.
2003: Nam D Tran; Xiaoming Liu; Ziying Yan; Duane Abbote; Qinshi Jiang; Eric B Kmiec; Curt D Sigmund; John F Engelhardt
Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(2):248-53.
2003: Gary L Baumbach; Curt D Sigmund; Frank M Faraci
Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen.
Hypertension 2003;41(1):50-5.
2002: Branimir Cvetkovic; Henry L Keen; Xiaoji Zhang; Deborah Davis; Baoli Yang; Curt D Sigmund
Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.
Physiological genomics 2002;11(3):253-62.
2002: Sean P Didion; Michael J Ryan; Lisa A Didion; Pamela E Fegan; Curt D Sigmund; Frank M Faraci
Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice.
Circulation research 2002;91(10):938-44.
2002: Gary L Baumbach; Curt D Sigmund; Teodoro Bottiglieri; Steven R Lentz
Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice.
Circulation research 2002;91(10):931-7.
2002: Sean P Didion; Michael J Ryan; Gary L Baumbach; Curt D Sigmund; Frank M Faraci
Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen.
American journal of physiology. Heart and circulatory physiology 2002;283(4):H1569-76.
2002: Satoshi Morimoto; Martin D Cassell; Curt D Sigmund
Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference.
The Journal of biological chemistry 2002;277(36):33235-41.
2002: Curt D Sigmund
Regulation of renin expression and blood pressure by vitamin D(3).
The Journal of clinical investigation 2002;110(2):155-6.
2002: Ravi Nistala; Curt D Sigmund
A reliable and efficient method for deleting operational sequences in PACs and BACs.
Nucleic acids research 2002;30(10):e41.
2002: Satoshi Morimoto; Curt D Sigmund
Angiotensin mutant mice: a focus on the brain renin-angiotensin system.
Neuropeptides 2002;36(2-3):194-200.
2002: Eric Lazartigues; Shannon M Dunlay; Angela K Loihl; Puspha Sinnayah; Julie A Lang; Joshua J Espelund; Curt D Sigmund; Robin L Davisson
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice.
Circulation research 2002;90(5):617-24.
2002: Michael J Ryan; Curt D Sigmund
Use of transgenic and knockout strategies in mice.
Seminars in nephrology 2002;22(2):154-60.
2002: David E Stec; Henry L Keen; Curt D Sigmund
Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase.
Hypertension 2002;39(2 Pt 2):629-33.
2002: Satoshi Morimoto; Martin D Cassell; Curt D Sigmund
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene.
Circulation research 2002;90(1):80-6.
2002: Susan B Glueck; Curt D Sigmund
Meeting report: Physiological Genomics of Cardiovascular Disease: from Technology to Physiology.
Physiological genomics 2002;9(3):135-6.
2002: Satoshi Morimoto; Martin D Cassell; Curt D Sigmund
Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite.
Physiological genomics 2002;9(2):113-20.
2002: Michael J Ryan; Sean P Didion; Deborah R Davis; Frank M Faraci; Curt D Sigmund
Endothelial dysfunction and blood pressure variability in selected inbred mouse strains.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(1):42-8.
2001: Li Pan; Thomas A Black; Q Shi; Craig A Jones; N Petrovic; J Loudon; C Kane; Curt D Sigmund; Kenneth W Gross
Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression.
The Journal of biological chemistry 2001;276(49):45530-8.
2001: Peggy S Myung; Geo S Derimanov; Martha S Jordan; Jennifer A Punt; Qing-Hua Liu; Barbi A Judd; E E Meyers; Curt D Sigmund; Bruce D Freedman; Gary A Koretzky
Differential requirement for SLP-76 domains in T cell development and function.
Immunity 2001;15(6):1011-26.
2001: K Wilson; GL Fry; DA Chappell; Curt D Sigmund; Jheem D Medh
Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1809-15.
2001: Curt D Sigmund
Genetic manipulation of the renin-angiotensin system in the kidney.
Acta physiologica Scandinavica 2001;173(1):67-73.
2001: Q Shi; Kenneth W Gross; Curt D Sigmund
NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors.
Hypertension 2001;38(3):332-6.
2001: Satoshi Morimoto; Martin D Cassell; Terry G Beltz; Alan Kim Johnson; Robin L Davisson; Curt D Sigmund
Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter.
Circulation research 2001;89(4):365-72.
2001: David E Stec; S Morimoto; Curt D Sigmund
Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice.
BioTechniques 2001;31(2):256-8, 260.
2001: Sanjana Dayal; Teodoro Bottiglieri; Erland Arning; Nobuyo Maeda; M Rene Malinow; Curt D Sigmund; Donald D Heistad; Frank M Faraci; Steven R Lentz
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice.
Circulation research 2001;88(11):1203-9.
2001: Curt D Sigmund
Genetic manipulation of the renin-angiotensin system: targeted expression of the renin-angiotensin system in the kidney.
American journal of hypertension 2001;14(6 Pt 2):33S-37S.
2001: David E Stec; Curt D Sigmund
Physiological insights from genetic manipulation of the renin-angiotensin system.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2001;16():80-4.
2001: Y Ding; David E Stec; Curt D Sigmund
Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen.
The Journal of biological chemistry 2001;276(10):7431-6.
2001: Ahmir H Khan; Debbie C Thurmond; Chunmei Yang; Brian P Ceresa; Curt D Sigmund; Jeffrey Pessin
Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle.
The Journal of biological chemistry 2001;276(6):4063-9.
2001: Q Shi; Kenneth W Gross; Curt D Sigmund
Retinoic acid-mediated activation of the mouse renin enhancer.
The Journal of biological chemistry 2001;276(5):3597-603.
2001: Henry L Keen; Curt D Sigmund
Paradoxical regulation of short promoter human renin transgene by angiotensin ii.
Hypertension 2001;37(2 Pt 2):403-7.
2001: Curt D Sigmund; David E Stec
Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase.
Methods in molecular medicine 2001;51():53-65.
2001: Y Ding; Curt D Sigmund
Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice.
American journal of physiology. Renal physiology 2001;280(1):F54-60.
2000: Robin L Davisson; M I Oliverio; T M Coffman; Curt D Sigmund
Divergent functions of angiotensin II receptor isoforms in the brain.
The Journal of clinical investigation 2000;106(1):103-6.
2000: Patrick L Sinn; Curt D Sigmund
Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation.
Physiological genomics 2000;3(1):25-31.
2000: Curt D Sigmund
Viewpoint: are studies in genetically altered mice out of control?
Arteriosclerosis, thrombosis, and vascular biology 2000;20(6):1425-9.
2000: Kristy D Lake-Bruse; Curt D Sigmund
Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways.
Current hypertension reports 2000;2(2):211-6.
2000: Qin Wang; Curt D Sigmund; Jim J-C Lin
Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice.
Circulation research 2000;86(4):478-84.
2000: Branimir Cvetkovic; Curt D Sigmund
Understanding hypertension through genetic manipulation in mice.
Kidney international 2000;57(3):863-74.
2000: Sean P Didion; Curt D Sigmund; Frank M Faraci
Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen.
Stroke; a journal of cerebral circulation 2000;31(3):760-4; discussion 765.
2000: Patrick L Sinn; Curt D Sigmund
Transgenic models as tools for studying the regulation of human renin expression.
Regulatory peptides 2000;86(1-3):77-82.
2000: Branimir Cvetkovic; Baoli Yang; R A Williamson; Curt D Sigmund
Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination.
The Journal of biological chemistry 2000;275(2):1073-8.
1999: Patrick L Sinn; Deborah R Davis; Curt D Sigmund
Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes.
The Journal of biological chemistry 1999;274(50):35785-93.
1999: Frank M Faraci; Curt D Sigmund
Vascular biology in genetically altered mice : smaller vessels, bigger insight.
Circulation research 1999;85(12):1214-25.
1999: Allyn L Mark; R A Shaffer; Marcelo L G Correia; Donald A Morgan; Curt D Sigmund; William G Haynes
Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice.
Journal of hypertension 1999;17(12 Pt 2):1949-53.
1999: Patrick L Sinn; X Zhang; Curt D Sigmund
JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter.
The American journal of physiology 1999;277(4 Pt 2):F634-42.
1999: Q Shi; T A Black; Kenneth W Gross; Curt D Sigmund
Species-specific differences in positive and negative regulatory elements in the renin gene enhancer.
Circulation research 1999;85(6):479-88.
1999: Kristy D Lake-Bruse; Frank M Faraci; Edward Shesely; Nobuyo Maeda; Curt D Sigmund; Donald D Heistad
Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice.
The American journal of physiology 1999;277(2 Pt 2):H770-6.
1999: David E Stec; Robin L Davisson; RE Haskell; Beverly L Davidson; Curt D Sigmund
Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo.
The Journal of biological chemistry 1999;274(30):21285-90.
1999: Robin L Davisson; Y Ding; David E Stec; James F Catterall; Curt D Sigmund
Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice.
Physiological genomics 1999;1(1):3-9.
1999: Patrick L Sinn; Curt D Sigmund
Human renin mRNA stability is increased in response to cAMP in Calu-6 cells.
Hypertension 1999;33(3):900-5.
1999: G Yang; T S Gray; Curt D Sigmund; Martin D Cassell
The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system.
Brain research 1999;817(1-2):123-31.
1998: Y Yan; R Chen; T Pitarresi; Curt D Sigmund; K W Gross; Jean E Sealey; John H Laragh; Daniel F Catanzaro
Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice.
Circulation research 1998;83(12):1279-88.
1998: Robin L Davisson; G Yang; Terry G Beltz; Martin D Cassell; Alan Kim Johnson; Curt D Sigmund
The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes.
Circulation research 1998;83(10):1047-58.
1998: David E Stec; Curt D Sigmund
Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system.
Experimental nephrology 1998;6(6):568-75.
1998: David E Stec; Robin L Davisson; Curt D Sigmund
Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension.
Trends in cardiovascular medicine 1998;8(6):256-64.
1998: G Yang; Curt D Sigmund
Developmental expression of human angiotensinogen in transgenic mice.
The American journal of physiology 1998;274(5 Pt 2):F932-9.
1998: G Yang; Curt D Sigmund
Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice.
Hypertension 1998;31(3):734-40.
1998: Frank M Faraci; Curt D Sigmund; Edward Shesely; Nobuyo Maeda; Donald D Heistad
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.
The American journal of physiology 1998;274(2 Pt 2):H564-70.
1997: D C Merrill; B P Granwehr; D R Davis; Curt D Sigmund
Use of transgenic and gene-targeted mice to model the genetic basis of hypertensive disorders.
Proceedings of the Association of American Physicians 1997;109(6):533-46.
1997: Y Ding; Robin L Davisson; Dianne O Hardy; L J Zhu; D C Merrill; James F Catterall; Curt D Sigmund
The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice.
The Journal of biological chemistry 1997;272(44):28142-8.
1997: Y Yan; C A Jones; Curt D Sigmund; K W Gross; Daniel F Catanzaro
Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells.
Circulation research 1997;81(4):558-66.
1997: N Petrovic; C M Kane; Curt D Sigmund; Kenneth W Gross
Downregulation of renin gene expression by interleukin-1.
Hypertension 1997;30(2 Pt 1):230-5.
1997: Robin L Davisson; Hyo-Soo Kim; John Krege; Donna J Lager; Oliver Smithies; Curt D Sigmund
Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes.
The Journal of clinical investigation 1997;99(6):1258-64.
1997: L Ying; B J Morris; Curt D Sigmund
Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells.
The Journal of biological chemistry 1997;272(4):2412-20.
1997: Craig A Jones; N Petrovic; Edward K Novak; Richard T Swank; Curt D Sigmund; Kenneth W Gross
Biosynthesis of renin in mouse kidney tumor As4.1 cells.
European journal of biochemistry / FEBS 1997;243(1-2):181-90.
1996: Robin L Davisson; Curt D Sigmund
Transgenic animal models as tools for studying renal developmental physiology.
Pediatric nephrology (Berlin, Germany) 1996;10(6):798-803.
1996: Robin L Davisson; N Nuutinen; Sean T Coleman; Curt D Sigmund
Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice.
Nucleic acids research 1996;24(20):4023-8.
1996: N Petrovic; T A Black; J R Fabian; C Kane; C A Jones; J A Loudon; J P Abonia; Curt D Sigmund; Kenneth W Gross
Role of proximal promoter elements in regulation of renin gene transcription.
The Journal of biological chemistry 1996;271(37):22499-505.
1996: M W Thompson; S B Smith; Curt D Sigmund
Regulation of human renin mRNA expression and protein release in transgenic mice.
Hypertension 1996;28(2):290-6.
1996: J A Lang; L Ying; Brian J Morris; Curt D Sigmund
Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells.
The American journal of physiology 1996;271(1 Pt 2):F94-100.
1996: D C Merrill; M W Thompson; C L Carney; B P Granwehr; G Schlager; Josée Robillard; Curt D Sigmund
Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.
The Journal of clinical investigation 1996;97(4):1047-55.
1995: M W Thompson; D C Merrill; G Yang; Josée Robillard; Curt D Sigmund
Transgenic animals in the study of blood pressure regulation and hypertension.
The American journal of physiology 1995;269(5 Pt 1):E793-803.
1995: H A Thompson; J M Burson; J A Lang; Kenneth W Gross; Curt D Sigmund
Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1).
Endocrinology 1995;136(7):3037-45.
1995: J A Lang; G Yang; J A Kern; Curt D Sigmund
Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line.
Hypertension 1995;25(4 Pt 2):704-10.
1994: G Yang; D C Merrill; M W Thompson; Josée Robillard; Curt D Sigmund
Functional expression of the human angiotensinogen gene in transgenic mice.
The Journal of biological chemistry 1994;269(51):32497-502.
1994: Werner Held; J G O'Brien; K Kerns; J F Gallagher; Curt D Sigmund; Kenneth W Gross
Chromosome 8 alterations accompany tumorigenesis in renin-SV40 T antigen transgenic mice.
Cancer research 1994;54(24):6496-9.
1994: Daniel F Catanzaro; J Sun; M T Gilbert; Y Yan; T Black; Curt D Sigmund; K W Gross
A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells.
Kidney international 1994;46(6):1513-5.
1994: J M Burson; G Aguilera; Kenneth W Gross; Curt D Sigmund
Differential expression of angiotensin receptor 1A and 1B in mouse.
The American journal of physiology 1994;267(2 Pt 1):E260-7.
1994: J A Lang; N L Sinclair; J M Burson; Curt D Sigmund
Transgenic animals as tools in hypertension research.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;205(2):106-18.
1993: Curt D Sigmund
Major approaches for generating and analyzing transgenic mice. An overview.
Hypertension 1993;22(4):599-607.
1993: Curt D Sigmund
Expression of the human renin gene in transgenic mice throughout ontogeny.
Pediatric nephrology (Berlin, Germany) 1993;7(5):639-45.
1992: Curt D Sigmund; C A Jones; C M Kane; C Wu; J A Lang; Kenneth W Gross
Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice.
Circulation research 1992;70(5):1070-9.
1992: S K Lim; Curt D Sigmund; K W Gross; Lynne E Maquat
Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.
Molecular and cellular biology 1992;12(3):1149-61.
1991: Curt D Sigmund; Kenneth W Gross
Structure, expression, and regulation of the murine renin genes.
Hypertension 1991;18(4):446-57.
1991: Howard J Jacob; Curt D Sigmund; T R Shockley; K W Gross; Victor J Dzau
Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia.
Hypertension 1991;17(6 Pt 2):1167-62.
1991: Curt D Sigmund; C A Jones; H J Jacob; J Ingelfinger; U Kim; D Gamble; V J Dzau; Kenneth W Gross
Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice.
The American journal of physiology 1991;260(2 Pt 2):F249-57.
1990: Curt D Sigmund; Kenneth W Gross
Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue.
Biochemical and biophysical research communications 1990;173(1):218-23.
1990: Curt D Sigmund; K Okuyama; J Ingelfinger; C A Jones; J J Mullins; C Kane; U Kim; C Z Wu; L Kenny; Y Rustum
Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.
The Journal of biological chemistry 1990;265(32):19916-22.
1990: Curt D Sigmund; C A Jones; J J Mullins; U Kim; Kenneth W Gross
Expression of murine renin genes in subcutaneous connective tissue.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7993-7.
1990: Curt D Sigmund; C A Jones; J R Fabian; J J Mullins; Kenneth W Gross
Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice.
Biochemical and biophysical research communications 1990;170(1):344-50.
1990: C A Jones; Curt D Sigmund; R A McGowan; C M Kane-Haas; Kenneth W Gross
Expression of murine renin genes during fetal development.
Molecular endocrinology (Baltimore, Md.) 1990;4(3):375-83.
1989: J J Mullins; Curt D Sigmund; C Kane-Haas; Kenneth W Gross; R A McGowan
Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice.
The EMBO journal 1989;8(13):4065-72.
1989: J R Fabian; L J Field; R A McGowan; J J Mullins; Curt D Sigmund; Kenneth W Gross
Allele-specific expression of the murine Ren-1 genes.
The Journal of biological chemistry 1989;264(29):17589-94.
1988: J J Mullins; Curt D Sigmund; C Kane-Haas; C Z Wu; F Pacholec; Q Zeng; Kenneth W Gross
Studies on the regulation of renin genes using transgenic mice.
Clinical and experimental hypertension. Part A, Theory and practice 1988;10(6):1157-67.