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Lorenzo Silengo

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Francesca Vinchi; Tim Townes; Fiorella Altruda; James Cimino; Lucia De Franceschi; Alessandra Ghigo; Emilio Hirsch; Lorenzo Silengo; noemi morello
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.
Vera Mugoni; Michael P Murphy; Ruben Postel; Jeroen Bakkers; Valeria Catanzaro; Elisa De Luca; Giuseppe Digilio; Claudio Medana; Lorenzo Silengo; Didier Y R Stainier; Emilia Turco; Massimo M Santoro
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.
Deborah Chiabrando; Veronica Fiorito; Samuele Marro; Lorenzo Silengo; Fiorella Altruda; noemi morello
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.

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2013: Francesca Vinchi; Tim Townes; Fiorella Altruda; James Cimino; Lucia De Franceschi; Alessandra Ghigo; Emilio Hirsch; Lorenzo Silengo; noemi morello
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.
Circulation 2013;127(12):1317-29.
2013: Vera Mugoni; Michael P Murphy; Ruben Postel; Jeroen Bakkers; Valeria Catanzaro; Elisa De Luca; Giuseppe Digilio; Claudio Medana; Lorenzo Silengo; Didier Y R Stainier; Emilia Turco; Massimo M Santoro
Ubiad1 is an antioxidant enzyme that regulates eNOS activity by CoQ10 synthesis.
Cell 2013;152(3):504-18.
2013: Deborah Chiabrando; Veronica Fiorito; Samuele Marro; Lorenzo Silengo; Fiorella Altruda; noemi morello
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Blood cells, molecules & diseases 2013;50(1):25-30.
2012: Deborah Chiabrando; Sharmila Fagoonee; Veronica Fiorito; Carlotta Giorgi; Samuele Marro; Sonia Mercurio; Giorgio R Merlo; Sara Petrillo; Paolo Pinton; Lorenzo Silengo; Fiorella Altruda; Annalisa Camporeale; Emilia Turco; Francesca Vinchi; Emanuela Tolosano
The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation.
The Journal of clinical investigation 2012;122(12):4569-79.
2012: Veronica Fiorito; Simonetta Geninatti Crich; Lorenzo Silengo; Silvio Aime; Fiorella Altruda; noemi morello
Assessment of iron absorption in mice by ICP-MS measurements of (57)Fe levels.
European journal of nutrition 2012;51(7):783-9.
2011: stefano buttiglieri; Alessandra Risso; Marco Ruella; Lorenzo Silengo; Tiziana Spatola; enrico vittorio avvedimento; Corrado Tarella
The aging effect of chemotherapy on cultured human mesenchymal stem cells.
Experimental hematology 2011;39(12):1171-81.
2011: Mauro Sbroggiò; Lorenzo Silengo; Emilia Turco; Silvia Velasco; Wadie F Bahou; Alessandro Bertero; Mara Brancaccio; Emanuele De Blasio; Federica Fusella; Guido Tarone
ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
Journal of cell science 2011;124(Pt 20):3515-24.
2011: Mauro Sbroggiò; Lorenzo Silengo; Emilia Turco; Wadie F Bahou; Alessandro Bertero; Mara Brancaccio; Daniela Carnevale; Giuseppe Cifelli; Emanuele De Blasio; Emilio Hirsch; Giuseppe Lembo; Giada Mascio; Guido Tarone
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.
Cardiovascular research 2011;91(3):456-64.
2011: Alessia Perino; Alessandra Ghigo; Enrico Ferrero; Fulvio Morello; Gaetano Santulli; George S Baillie; Federico Damilano; Allan J Dunlop; Catherine Pawson; Romy Walser; Renzo Levi; Fiorella Altruda; Lorenzo Silengo; Lorene K Langeberg; Gitte Neubauer; Stephane Heymans; Giuseppe Lembo; Matthias P Wymann; Reinhard Wetzker; Miles D Houslay; Guido Iaccarino; John D Scott; Emilio Hirsch
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Molecular cell 2011;42(1):84-95.
2011: Sharmila Fagoonee; Rinaldo Pellicano; Lorenzo Silengo; Fiorella Altruda
Potential applications of germline cell-derived pluripotent stem cells in organ regeneration.
Organogenesis 2011;7(2):116-22.
2011: Noemi Morello; Federico Tommaso Bianchi; Paola Marmiroli; Elisabetta Tonoli; Virginia Rodriguez-Menendez; Lorenzo Silengo; Guido Cavaletti; Alessandro Vercelli; Fiorella Altruda; noemi morello
A role for hemopexin in oligodendrocyte differentiation and myelin formation.
PloS one 2011;6(5):e20173.
2010: Sharmila Fagoonee; Robin M Hobbs; Letizia De Chiara; Daniela Cantarella; Rosario Michael Piro; Emanuela Tolosano; Enzo Medico; Paolo Provero; Pier Paolo Pandolfi; Lorenzo Silengo; Fiorella Altruda
Generation of functional hepatocytes from mouse germ line cell-derived pluripotent stem cells in vitro.
Stem cells and development 2010;19(8):1183-94.
2010: Roberta Ferretti; Valeria Palumbo; Augusta Di Savino; Silvia Velasco; Mauro Sbroggiò; Paolo Sportoletti; Lucia Micale; Emilia Turco; Lorenzo Silengo; Gioacchino Palumbo; Emilio Hirsch; Julie T Feldstein; Silvia Bonaccorsi; Pier Paolo Pandolfi; Maurizio Gatti; Guido Tarone; Mara Brancaccio
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
Developmental cell 2010;18(3):486-95.
2010: Miriam Canavese; Fiorella Altruda; Lorenzo Silengo
Therapeutic efficacy and immunological response of CCL5 antagonists in models of contact skin reaction.
PloS one 2010;5(1):e8725.
2009: Noemi Morello; Elisabetta Tonoli; Federica Logrand; Veronica Fiorito; Sharmila Fagoonee; Emilia Turco; Lorenzo Silengo; Alessandro Vercelli; Fiorella Altruda; noemi morello
Haemopexin affects iron distribution and ferritin expression in mouse brain.
Journal of cellular and molecular medicine 2009;13(10):4192-204.
2009: Sara Cabodi; Virginia Morello; Alessio Masi; Riccardo Cicchi; Chiara Broggio; Paola Distefano; Elisa Brunelli; Lorenzo Silengo; Francesco Pavone; Annarosa Arcangeli; Emilia Turco; Guido Tarone; Laura Moro; Paola Defilippi
Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.
Journal of cellular physiology 2009;218(2):294-303.
2008: Sharmila Fagoonee; Cristiana Caorsi; Mirella Giovarelli; Meredin Stoltenberg; Lorenzo Silengo; Fiorella Altruda; Giovanni Camussi; Emanuela Tolosano; Benedetta Bussolati
Lack of plasma protein hemopexin dampens mercury-induced autoimmune response in mice.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(3):1937-47.
2008: Francesca Vinchi; Stefania Gastaldi; Lorenzo Silengo; Fiorella Altruda; Emanuela Tolosano
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload.
The American journal of pathology 2008;173(1):289-99.
2008: Mauro Sbroggiò; Roberta Ferretti; Elena Percivalle; Malgorzata Gutkowska; Alicja Zylicz; Wojciech Michowski; Jacek Kuznicki; Federica Accornero; Beniamina Pacchioni; Gerolamo Lanfranchi; Jorg Hamm; Emilia Turco; Lorenzo Silengo; Guido Tarone; Mara Brancaccio
The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1.
FEBS letters 2008;582(13):1788-94.
2008: Ugo Ala; Rosario Michael Piro; Elena Grassi; Christian Damasco; Lorenzo Silengo; Martin Oti; Paolo Provero; Ferdinando Di Cunto
Prediction of human disease genes by human-mouse conserved coexpression analysis.
PLoS computational biology 2008;4(3):e1000043.
2008: Jörg Hamm; Roberta Pulito; Sabrina Benedetto; Laura Barberis; Emilio Hirsch; Valeria Poli; Lorenzo Silengo
Magnetically enriched bone marrow-derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice.
NMR in biomedicine 2008;21(2):120-8.
2008: Elisa Ciraolo; Manuela Iezzi; Romina Marone; Stefano Marengo; Claudia Curcio; Carlotta Costa; Ornella Azzolino; Cristiano Gonella; Cristina Rubinetto; Haiyan Wu; Walter Dastrù; Erica L Martin; Lorenzo Silengo; Fiorella Altruda; Emilia Turco; Letizia Lanzetti; Piero Musiani; Thomas Rückle; Christian Rommel; Jonathan M Backer; Guido Forni; Matthias P Wymann; Emilio Hirsch
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
Science signaling 2008;1(36):ra3.
2008: Laura Miozzi; Rosario Michael Piro; Fabio Rosa; Ugo Ala; Lorenzo Silengo; Ferdinando Di Cunto; Paolo Provero
Functional annotation and identification of candidate disease genes by computational analysis of normal tissue gene expression data.
PloS one 2008;3(6):e2439.
2007: Samuele Marro; Donatella Barisani; Deborah Chiabrando; Sharmila Fagoonee; Martina U Muckenthaler; Jens Stolte; Raffaella Meneveri; David Haile; Lorenzo Silengo; Fiorella Altruda; Emanuela Tolosano
Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression.
Gastroenterology 2007;133(4):1261-1271.
2007: Paola Di Stefano; Laura Damiano; Sara Cabodi; Simona Aramu; Luca Tordella; Alice Praduroux; Roberto Piva; Federica Cavallo; Guido Forni; Lorenzo Silengo; Guido Tarone; Emilia Turco; Paola Defilippi
p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.
The EMBO journal 2007;26(12):2843-55.
2007: Gaia Berto; Paola Camera; Carlo Fusco; Sara Imarisio; Chiara Ambrogio; Roberto Chiarle; Lorenzo Silengo; Ferdinando Di Cunto
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Journal of cell science 2007;120(Pt 11):1859-67.
2006: Sabrina Benedetto; Roberta Pulito; Simonetta Geninatti Crich; Guido Tarone; Silvio Aime; Lorenzo Silengo; Jörg Hamm
Quantification of the expression level of integrin receptor alpha(v)beta3 in cell lines and MR imaging with antibody-coated iron oxide particles.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(4):711-6.
2006: Sharmila Fagoonee; Ferdinando Di Cunto; Diego Vozzi; Stefano Volinia; Maurizio Pellegrino; Paolo Gasparini; Lorenzo Silengo; Fiorella Altruda; Emanuela Tolosano
Microarray and large-scale in silico--based identification of genes functionally related to Haptoglobin and/or Hemopexin.
DNA and cell biology 2006;25(6):323-30.
2006: Sara Cabodi; Agata Tinnirello; Paola Di Stefano; Brigitte Bisarò; Elena Ambrosino; Isabella Castellano; Anna Sapino; RICCARDO ARISIO; Federica Cavallo; Guido Forni; Marina Glukhova; Lorenzo Silengo; Fiorella Altruda; Emilia Turco; Guido Tarone; Paola Defilippi
p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.
Cancer research 2006;66(9):4672-80.
2005: Fiorella Balzac; Maria Avolio; Simona Degani; Irina Kaverina; Mauro Torti; Lorenzo Silengo; J Victor Small; SAVERIO FRANCESCO RETTA
E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function.
Journal of cell science 2005;118(Pt 20):4765-83.
2005: Elisabetta Boeri Erba; Elena Bergatto; Sara Cabodi; Lorenzo Silengo; Guido Tarone; Paola Defilippi; Ole N Jensen
Systematic analysis of the epidermal growth factor receptor by mass spectrometry reveals stimulation-dependent multisite phosphorylation.
Molecular & cellular proteomics : MCP 2005;4(8):1107-21.
2005: Marika De Acetis; Antonella Notte; Federica Accornero; Giulio Selvetella; Mara Brancaccio; Carmine Vecchione; Mauro Sbroggiò; Federica Collino; Beniamina Pacchioni; Gerolamo Lanfranchi; Alessandra Aretini; Roberta Ferretti; Angelo Maffei; Fiorella Altruda; Lorenzo Silengo; Guido Tarone; Giuseppe Lembo
Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.
Circulation research 2005;96(10):1087-94.
2005: Carmine Vecchione; Enrico Patrucco; Gennaro Marino; Laura Barberis; Roberta Poulet; Alessandra Aretini; Angelo Maffei; Maria Teresa Gentile; marianna storto; Ornella Azzolino; Mara Brancaccio; Gian Luca Colussi; Umberto Bettarini; Fiorella Altruda; Lorenzo Silengo; Guido Tarone; Matthias P Wymann; Emilio Hirsch; Giuseppe Lembo
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.
The Journal of experimental medicine 2005;201(8):1217-28.
2005: Sharmila Fagoonee; Jakub Gburek; Emilio Hirsch; Samuele Marro; Søren K Moestrup; Jacob M Laurberg; Erik I Christensen; Lorenzo Silengo; Fiorella Altruda; Emanuela Tolosano
Plasma protein haptoglobin modulates renal iron loading.
The American journal of pathology 2005;166(4):973-83.
2004: Maurizio Pellegrino; Paolo Provero; Lorenzo Silengo; Ferdinando Di Cunto
CLOE: identification of putative functional relationships among genes by comparison of expression profiles between two species.
BMC bioinformatics 2004;5():179.
2004: Valentina Fiano; Chiara Ghimenti; Sara Imarisio; Lorenzo Silengo; Davide Schiffer
PAkt, cyclin D1 and p27/Kip.1 in glioblastomas with and without EGFR amplification and PTEN mutation.
Anticancer research 2004;24(5A):2643-7.
2004: Enrico Patrucco; Antonella Notte; Laura Barberis; Giulio Selvetella; Angelo Maffei; Mara Brancaccio; Stefano Marengo; Giovanni Russo; Ornella Azzolino; Sergei D Rybalkin; Lorenzo Silengo; Fiorella Altruda; Reinhard Wetzker; Matthias P Wymann; Giuseppe Lembo; Emilio Hirsch
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
Cell 2004;118(3):375-87.
2004: Davide Corà; Ferdinando Di Cunto; Paolo Provero; Lorenzo Silengo; Michele Caselle
Computational identification of transcription factor binding sites by functional analysis of sets of genes sharing overrepresented upstream motifs.
BMC bioinformatics 2004;5():57.
2004: Sara Cabodi; Laura Moro; Germano Baj; Monica Smeriglio; Paola Di Stefano; Silvana Gippone; Nicola Surico; Lorenzo Silengo; Emilia Turco; Guido Tarone; Paola Defilippi
p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells.
Journal of cell science 2004;117(Pt 8):1603-11.
2004: Rinaldo Pellicano; Vincenzo Mazzaferro; Walter Franco Grigioni; Miguel Angel Cutufia; Sharmila Fagoonee; Lorenzo Silengo; Mario Rizzetto; Antonio Ponzetto
Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma.
World journal of gastroenterology : WJG 2004;10(4):598-601.
2004: Paola Di Stefano; Sara Cabodi; Elisabetta Boeri Erba; valentina margaria; Elena Bergatto; Maria Gabriella Giuffrida; Lorenzo Silengo; Guido Tarone; Emilia Turco; Paola Defilippi
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading.
Molecular biology of the cell 2004;15(2):787-800.
2004: SAVERIO FRANCESCO RETTA; Maria Avolio; Floriana Francalanci; Simone Procida; Fiorella Balzac; Simona Degani; Guido Tarone; Lorenzo Silengo
Identification of Krit1B: a novel alternative splicing isoform of cerebral cavernous malformation gene-1.
Gene 2004;325():63-78.
2003: Paola Camera; Jorge Santos da Silva; Gareth Griffiths; Maria Gabriella Giuffrida; Luciana Ferrara; Vanessa Schubert; Sara Imarisio; Lorenzo Silengo; Carlos G Dotti; Ferdinando Di Cunto
Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.
Nature cell biology 2003;5(12):1071-8.
2003: Mara Brancaccio; Nadia Menini; Daniela Bongioanni; Roberta Ferretti; Marika De Acetis; Lorenzo Silengo; Guido Tarone
Chp-1 and melusin, two CHORD containing proteins in vertebrates.
FEBS letters 2003;551(1-3):47-52.
2003: Ferdinando Di Cunto; Luciana Ferrara; Roberta Curtetti; Sara Imarisio; Simona Guazzone; Vania Broccoli; Alessandro Bulfone; Fiorella Altruda; Alessandro Vercelli; Lorenzo Silengo
Role of citron kinase in dendritic morphogenesis of cortical neurons.
Brain research bulletin 2003;60(4):319-27.
2003: Mara Brancaccio; Luigi Fratta; Antonella Notte; Emilio Hirsch; Roberta Poulet; Simona Guazzone; Marika De Acetis; Carmine Vecchione; Gennaro Marino; Fiorella Altruda; Lorenzo Silengo; Guido Tarone; Giuseppe Lembo
Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.
Nature medicine 2003;9(1):68-75.
2002: Ferdinando Di Cunto; Sara Imarisio; Paola Camera; Carla Boitani; Fiorella Altruda; Lorenzo Silengo
Essential role of citron kinase in cytokinesis of spermatogenic precursors.
Journal of cell science 2002;115(Pt 24):4819-26.
2002: Emanuela Tolosano; Sharmila Fagoonee; Emilio Hirsch; Franklin G Berger; Heinz Baumann; Lorenzo Silengo; Fiorella Altruda
Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis.
Blood 2002;100(12):4201-8.
2002: Emilio Hirsch; Michela Pozzato; Alessandro Vercelli; Laura Barberis; Ornella Azzolino; Chiara Russo; Cristina Vanni; Lorenzo Silengo; Alessandra Eva; Fiorella Altruda
Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl.
Molecular and cellular biology 2002;22(9):3140-8.
2002: Emilio Hirsch; Laura Barberis; Mara Brancaccio; Ornella Azzolino; Dazhong Xu; John Kyriakis; Lorenzo Silengo; Filippo G Giancotti; Guido Tarone; Reinhard Fässler; Fiorella Altruda
Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain.
The Journal of cell biology 2002;157(3):481-92.
2002: Laura Moro; Laura Dolce; Sara Cabodi; Elena Bergatto; Elisabetta Boeri Erba; Monica Smeriglio; Emilia Turco; SAVERIO FRANCESCO RETTA; Maria Gabriella Giuffrida; Mascia Venturino; Jasminka Godovac-Zimmermann; Amedeo Conti; Erik M Schaefer; Laura Beguinot; Carlo Tacchetti; Paolo Gaggini; Lorenzo Silengo; Guido Tarone; Paola Defilippi
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines.
The Journal of biological chemistry 2002;277(11):9405-14.
2002: Simona Degani; Fiorella Balzac; Mara Brancaccio; Simona Guazzone; SAVERIO FRANCESCO RETTA; Lorenzo Silengo; Alessandra Eva; Guido Tarone
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
The Journal of cell biology 2002;156(2):377-87.
2001: SAVERIO FRANCESCO RETTA; G Cassarà; M D'Amato; Riccardo Alessandro; Maurizio Pellegrino; Simona Degani; G De Leo; Lorenzo Silengo; Guido Tarone
Cross talk between beta(1) and alpha(V) integrins: beta(1) affects beta(3) mRNA stability.
Molecular biology of the cell 2001;12(10):3126-38.
2000: Ferdinando Di Cunto; Sara Imarisio; E Hirsch; Vania Broccoli; Alessandro Bulfone; antonio migheli; Cristiana Atzori; Emilia Turco; R Triolo; G Paolo Dotto; Lorenzo Silengo; Fiorella Altruda
Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.
Neuron 2000;28(1):115-27.
2000: C Olivo; Cristina Vanni; Patrizia Mancini; Lorenzo Silengo; Maria Rosaria Torrisi; Guido Tarone; Paola Defilippi; Alessandra Eva
Distinct involvement of cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH3T3 cells.
Oncogene 2000;19(11):1428-36.
2000: Emilio Hirsch; VL Katanaev; Cecilia Garlanda; Ornella Azzolino; Luciano Pirola; Lorenzo Silengo; S Sozzani; A Mantovani; Fiorella Altruda; Matthias P Wymann
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
Science (New York, N.Y.) 2000;287(5455):1049-53.
2000: Antonio Ponzetto; Rinaldo Pellicano; Nicola Leone; Miguel Angel Cutufia; F Turrini; Walter Franco Grigioni; A D'Errico; P Mortimer; Mario Rizzetto; Lorenzo Silengo
Helicobacter infection and cirrhosis in hepatitis C virus carriage: is it an innocent bystander or a troublemaker?
Medical hypotheses 2000;54(2):275-7.
2000: Guido Tarone; Emilio Hirsch; Mara Brancaccio; Marika De Acetis; Laura Barberis; Fiorella Balzac; SAVERIO FRANCESCO RETTA; C Botta; Fiorella Altruda; Lorenzo Silengo; F Retta
Integrin function and regulation in development.
The International journal of developmental biology 2000;44(6):725-31.
1999: Emanuela Tolosano; Emilio Hirsch; Enrico Patrucco; Clara Camaschella; ROBERTO NAVONE; Lorenzo Silengo; Fiorella Altruda
Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice.
Blood 1999;94(11):3906-14.
1999: Mara Brancaccio; Simona Guazzone; N Menini; E Sibona; Emilio Hirsch; Marco De Andrea; M Rocchi; Fiorella Altruda; Guido Tarone; Lorenzo Silengo
Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain.
The Journal of biological chemistry 1999;274(41):29282-8.
1999: Maria Felice Brizzi; Paola Defilippi; Arturo Rosso; Mascia Venturino; Giovanni Garbarino; A Miyajima; Lorenzo Silengo; Guido Tarone; Luigi Pegoraro
Integrin-mediated adhesion of endothelial cells induces JAK2 and STAT5A activation: role in the control of c-fos gene expression.
Molecular biology of the cell 1999;10(10):3463-71.
1999: Paola Defilippi; C Olivo; Mascia Venturino; L Dolce; Lorenzo Silengo; Guido Tarone
Actin cytoskeleton organization in response to integrin-mediated adhesion.
Microscopy research and technique 1999;47(1):67-78.
1999: D Tomatis; F Echtermayer; S Schöber; Fiorella Balzac; SAVERIO FRANCESCO RETTA; Lorenzo Silengo; Guido Tarone
The muscle-specific laminin receptor alpha7 beta1 integrin negatively regulates alpha5 beta1 fibronectin receptor function.
Experimental cell research 1999;246(2):421-32.
1999: Emilio Hirsch; P Cervella; Lorenzo Silengo; Fiorella Altruda
Determination of positive and negative regulatory elements.
Methods in molecular biology (Clifton, N.J.) 1999;129():189-208.
1998: Laura Moro; Mascia Venturino; Chiarella Bozzo; Lorenzo Silengo; Fiorella Altruda; L Beguinot; Guido Tarone; Paola Defilippi
Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival.
The EMBO journal 1998;17(22):6622-32.
1998: SAVERIO FRANCESCO RETTA; Fiorella Balzac; P Ferraris; Alexey M Belkin; Reinhard Fässler; M J Humphries; G De Leo; Lorenzo Silengo; Guido Tarone
beta1-integrin cytoplasmic subdomains involved in dominant negative function.
Molecular biology of the cell 1998;9(4):715-31.
1998: Mara Brancaccio; Sara Cabodi; Alexey M Belkin; G Collo; V E Koteliansky; D Tomatis; Fiorella Altruda; Lorenzo Silengo; Guido Tarone
Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development.
Cell adhesion and communication 1998;5(3):193-205.
1997: Chiarella Bozzo; G Bellomo; Lorenzo Silengo; Guido Tarone; Fiorella Altruda
Soluble integrin ligands and growth factors independently rescue neuroblastoma cells from apoptosis under nonadherent conditions.
Experimental cell research 1997;237(2):326-37.
1997: Alexey M Belkin; SAVERIO FRANCESCO RETTA; O Y Pletjushkina; Fiorella Balzac; Lorenzo Silengo; R Fassler; V E Koteliansky; Keith Burridge; Guido Tarone
Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing.
The Journal of cell biology 1997;139(6):1583-95.
1997: Paola Defilippi; Mascia Venturino; D Gulino; A Duperray; P Boquet; C Fiorentini; Gisella Volpe; M Palmieri; Lorenzo Silengo; Guido Tarone
Dissection of pathways implicated in integrin-mediated actin cytoskeleton assembly. Involvement of protein kinase C, Rho GTPase, and tyrosine phosphorylation.
The Journal of biological chemistry 1997;272(35):21726-34.
1997: Annalisa Chiocchetti; Emanuela Tolosano; Emilio Hirsch; Lorenzo Silengo; Fiorella Altruda
Green fluorescent protein as a reporter of gene expression in transgenic mice.
Biochimica et biophysica acta 1997;1352(2):193-202.
1996: SAVERIO FRANCESCO RETTA; Simon T Barry; David R Critchley; Paola Defilippi; Lorenzo Silengo; Guido Tarone
Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity.
Experimental cell research 1996;229(2):307-17.
1996: Emanuela Tolosano; M A Cutufia; Emilio Hirsch; G Stefanuto; S Voyron; Aldo Fasolo; Lorenzo Silengo; Fiorella Altruda
Ciliary neurotrophic factor constitutively expressed in the nervous system of transgenic mice protects embryonic dorsal root ganglion neurons from apoptosis.
The European journal of neuroscience 1996;8(3):521-9.
1996: Emanuela Tolosano; M A Cutufia; Emilio Hirsch; Lorenzo Silengo; Fiorella Altruda
Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice.
Biochemical and biophysical research communications 1996;218(3):694-703.
1995: G Stefanuto; M Cerrato; A Chiocchetti; Emanuela Tolosano; Emilio Hirsch; R Cristofori; Lorenzo Silengo; Fiorella Altruda
Analysis of regulatory regions of the ciliary neutrophic factor gene in transgenic mice.
Neuroreport 1995;7(1):57-60.
1995: Paola Defilippi; SAVERIO FRANCESCO RETTA; C Olivo; M Palmieri; Mascia Venturino; Lorenzo Silengo; Guido Tarone
p125FAK tyrosine phosphorylation and focal adhesion assembly: studies with phosphotyrosine phosphatase inhibitors.
Experimental cell research 1995;221(1):141-52.
1995: Maria G Giacobini-Robecchi; P Borrione; M Canavese; Stefano Geuna; A Paraninfo; A Poncino; Lorenzo Silengo
DNA neosynthesis in Auerbach plexus ganglia isolated from the rat hypertrophic gut: an electrophoretic analysis.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(6):635-7.
1995: P Rossino; Gisella Volpe; Alessandro Negro; L Callegaro; Fiorella Altruda; Guido Tarone; Lorenzo Silengo
Ciliary neurotrophic factor-induced gene expression in human neuroblastoma cell lines.
Neurochemical research 1995;20(6):675-80.
1994: E Hirsch; Donald Gullberg; Fiorella Balzac; Fiorella Altruda; Lorenzo Silengo; Guido Tarone
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development.
Developmental dynamics : an official publication of the American Association of Anatomists 1994;201(2):108-20.
1994: Fiorella Balzac; SAVERIO FRANCESCO RETTA; Adriana Albini; A Melchiorri; V E Koteliansky; Massimo Geuna; Lorenzo Silengo; Guido Tarone
Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.
The Journal of cell biology 1994;127(2):557-65.
1994: Chiarella Bozzo; Paola Defilippi; Lorenzo Silengo; Guido Tarone
Role of tyrosine phosphorylation in matrix-induced neurite outgrowth in human neuroblastoma cells.
Experimental cell research 1994;214(1):313-22.
1994: Paola Defilippi; Chiarella Bozzo; Gisella Volpe; G Romano; Mascia Venturino; Lorenzo Silengo; Guido Tarone
Integrin-mediated signal transduction in human endothelial cells: analysis of tyrosine phosphorylation events.
Cell adhesion and communication 1994;2(1):75-86.
1993: E Hirsch; Fiorella Balzac; C Pastore; Guido Tarone; Lorenzo Silengo; Fiorella Altruda
The beta 1 integrin distal promoter is developmentally regulated in transgenic mice.
Cell adhesion and communication 1993;1(3):203-12.
1993: Guido Tarone; M A Russo; E Hirsch; T Odorisio; Fiorella Altruda; Lorenzo Silengo; Gregorio Siracusa
Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte.
Development (Cambridge, England) 1993;117(4):1369-75.
1993: Fiorella Balzac; Alexey M Belkin; V E Koteliansky; Y V Balabanov; Fiorella Altruda; Lorenzo Silengo; Guido Tarone
Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit.
The Journal of cell biology 1993;121(1):171-8.
1993: P Cervella; Lorenzo Silengo; C Pastore; Fiorella Altruda
Human beta 1-integrin gene expression is regulated by two promoter regions.
The Journal of biological chemistry 1993;268(7):5148-55.
1993: Paola Defilippi; Lorenzo Silengo; Guido Tarone
Regulation of adhesion receptors expression in endothelial cells.
Current topics in microbiology and immunology 1993;184():87-98.
1992: Paola Defilippi; Lorenzo Silengo; Guido Tarone
Alpha 6.beta 1 integrin (laminin receptor) is down-regulated by tumor necrosis factor alpha and interleukin-1 beta in human endothelial cells.
The Journal of biological chemistry 1992;267(26):18303-7.
1992: Mauro Magnani; M Bianchi; A Casabianca; Vilberto Stocchi; A Daniele; Fiorella Altruda; Marina Ferrone; Lorenzo Silengo
A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates.
The Biochemical journal 1992;285 ( Pt 1)():193-9.
1992: A Daniele; Fiorella Altruda; Marina Ferrone; Lorenzo Silengo; G Romeo; N Archidiacono; M Rocchi
Mapping of human hexokinase 1 gene to 10q11----qter.
Human heredity 1992;42(2):107-10.
1992: Paola Defilippi; Chiarella Bozzo; Massimo Geuna; P Rossino; Lorenzo Silengo; Guido Tarone
Modulation of extracellular matrix receptors (integrins) on human endothelial cells by cytokines.
EXS 1992;61():193-7.
1991: P Borrione; P Cervella; Stefano Geuna; Maria G Giacobini-Robecchi; A Poncino; Lorenzo Silengo
Electrophoretic analysis of neuronal genomic DNA from hypertrophic spinal ganglia during lizard tail regeneration.
Neuroscience letters 1991;133(2):245-8.
1991: P Rossino; Paola Defilippi; Lorenzo Silengo; Guido Tarone
Up-regulation of the integrin alpha 1/beta 1 in human neuroblastoma cells differentiated by retinoic acid: correlation with increased neurite outgrowth response to laminin.
Cell regulation 1991;2(12):1021-33.
1991: A Daniele; Fiorella Altruda; Marina Ferrone; Lorenzo Silengo; L Chiarantini; M Bianchi; Vilberto Stocchi; Mauro Magnani
Cloning and expression of a new human polypeptide which regulates protein phosphorylation in Escherichia coli.
Molecular and cellular biochemistry 1991;107(2):87-94.
1991: Alessandro Negro; Emanuela Tolosano; Stephen Skaper; I Martini; L Callegaro; Lorenzo Silengo; F Fiorini; Fiorella Altruda
Cloning and expression of human ciliary neurotrophic factor.
European journal of biochemistry / FEBS 1991;201(1):289-94.
1991: Paola Defilippi; V van Hinsbergh; Antonio Bertolotto; P Rossino; Lorenzo Silengo; Guido Tarone
Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells.
The Journal of cell biology 1991;114(4):855-63.
1991: Paola Defilippi; G Truffa; G Stefanuto; Fiorella Altruda; Lorenzo Silengo; Guido Tarone
Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothelial cells.
The Journal of biological chemistry 1991;266(12):7638-45.
1990: Fiorella Altruda; P Cervella; Guido Tarone; C Botta; Fiorella Balzac; G Stefanuto; Lorenzo Silengo
A human integrin beta 1 subunit with a unique cytoplasmic domain generated by alternative mRNA processing.
Gene 1990;95(2):261-6.
1990: P Rossino; I Gavazzi; R Timpl; M Aumailley; M Abbadini; Filippo G Giancotti; Lorenzo Silengo; Pier Carlo Marchisio; Guido Tarone
Nerve growth factor induces increased expression of a laminin-binding integrin in rat pheochromocytoma PC12 cells.
Experimental cell research 1990;189(1):100-8.
1990: Guido Tarone; G Stefanuto; P Mascarello; Paola Defilippi; Fiorella Altruda; Lorenzo Silengo
Expression of receptors for extracellular matrix proteins in human endothelial cells.
Journal of lipid mediators 1990;2 Suppl():S45-53.
1989: Fiorella Altruda; P Cervella; M L Gaeta; A Daniele; Filippo G Giancotti; Guido Tarone; G Stefanuto; Lorenzo Silengo
Cloning of cDNA for a novel mouse membrane glycoprotein (gp42): shared identity to histocompatibility antigens, immunoglobulins and neural-cell adhesion molecules.
Gene 1989;85(2):445-51.
1989: V Poli; Lorenzo Silengo; Fiorella Altruda; Riccardo Cortese
The analysis of the human hemopexin promoter defines a new class of liver-specific genes.
Nucleic acids research 1989;17(22):9351-65.
1988: Fiorella Altruda; V Poli; G Restagno; Lorenzo Silengo
Structure of the human hemopexin gene and evidence for intron-mediated evolution.
Journal of molecular evolution 1988;27(2):102-8.
1987: Susan Naylor; Fiorella Altruda; A Marshall; Lorenzo Silengo; B H Bowman
Hemopexin is localized to human chromosome 11.
Somatic cell and molecular genetics 1987;13(4):355-8.
1986: V Poli; Fiorella Altruda; Lorenzo Silengo
Differential transcriptional pattern of the hemopexin gene.
The Italian journal of biochemistry 1986;35(5):355-60.
1986: C Santoro; M Marone; Marina Ferrone; Francesco Costanzo; M Colombo; C Minganti; Riccardo Cortese; Lorenzo Silengo
Cloning of the gene coding for human L apoferritin.
Nucleic acids research 1986;14(7):2863-76.
1985: Fiorella Altruda; V Poli; G Restagno; P Argos; Riccardo Cortese; Lorenzo Silengo
The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology.
Nucleic acids research 1985;13(11):3841-59.