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Thomas Silhavy
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12
Kahne, Daniel
12
Ruiz, Natividad
8
Danese, PN
6
Raivio, Tracy
6
Malinverni, Juliana
5
Peterson, Celeste
5
Wu, Tao
4
Hultgren, Scott
3
Gronenberg, Luisa
3
Hand, Nicholas
3
Harper, Jill Reiss
3
Kim, Seokhee
3
Duguay, Amy
3
Pinkner, Jerome
3
Sklar, Joseph
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All Publications
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2009: Carabetta Valerie J; Mohanty Bijoy K; Kushner Sidney R; Silhavy Thomas J
The response regulator SprE (RssB) modulates polyadenylation and mRNA stability in Escherichia coli.
Journal of bacteriology 2009;191(22):6812-21.
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2009: Ruiz Natividad; Kahne Daniel; Silhavy Thomas J
Transport of lipopolysaccharide across the cell envelope: the long road of discovery.
Nature reviews. Microbiology 2009;7(9):677-83.
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2009: van Stelten Johna; Silva Filo; Belin Dominique; Silhavy Thomas J
Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY.
Science (New York, N.Y.) 2009;325(5941):753-6.
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2009: Malinverni Juliana C; Silhavy Thomas J
An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(19):8009-14.
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2009: Vertommen Didier; Ruiz Natividad; Leverrier Pauline; Silhavy Thomas J; Collet Jean-François
Characterization of the role of the Escherichia coli periplasmic chaperone SurA using differential proteomics.
Proteomics 2009;9(9):2432-43.
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2008: Aoki Stephanie K; Malinverni Juliana C; Jacoby Kyle; Thomas Benjamin; Pamma Rupinderjit; Trinh Brooke N; Remers Susan; Webb Julia; Braaten Bruce A; Silhavy Thomas J; Low David A
Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB.
Molecular microbiology 2008;70(2):323-40.
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2008: Silhavy Thomas J; Gitai Zemer
Sex to the rescue.
Nature methods 2008;5(9):759-60.
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2008: Sperandeo Paola; Lau Fion K; Carpentieri Andrea; De Castro Cristina; Molinaro Antonio; Dehò Gianni; Silhavy Thomas J; Polissi Alessandra
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal of bacteriology 2008;190(13):4460-9.
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2008: Ruiz Natividad; Gronenberg Luisa S; Kahne Daniel; Silhavy Thomas J
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5537-42.
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2007: Sklar Joseph G; Wu Tao; Kahne Daniel; Silhavy Thomas J
Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli.
Genes & development 2007;21(19):2473-84.
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2007: Schmidt Oliver; Schuenemann Verena J; Hand Nicholas J; Silhavy Thomas J; Martin Jörg; Lupas Andrei N; Djuranovic Sergej
prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli.
Journal of molecular biology 2007;372(4):894-905.
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2007: Kim Seokhee; Malinverni Juliana C; Sliz Piotr; Silhavy Thomas J; Harrison Stephen C; Kahne Daniel
Structure and function of an essential component of the outer membrane protein assembly machine.
Science (New York, N.Y.) 2007;317(5840):961-4.
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2007: Sklar Joseph G; Wu Tao; Gronenberg Luisa S; Malinverni Juliana C; Kahne Daniel; Silhavy Thomas J
Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6400-5.
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2007: Fredriksson Asa; Ballesteros Manuel; Peterson Celeste N; Persson Orjan; Silhavy Thomas J; Nyström Thomas
Decline in ribosomal fidelity contributes to the accumulation and stabilization of the master stress response regulator sigmaS upon carbon starvation.
Genes & development 2007;21(7):862-74.
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2007: Button Julie E; Silhavy Thomas J; Ruiz Natividad
A suppressor of cell death caused by the loss of sigmaE downregulates extracytoplasmic stress responses and outer membrane vesicle production in Escherichia coli.
Journal of bacteriology 2007;189(5):1523-30.
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2007: Ureta Alejandro R; Endres Robert G; Wingreen Ned S; Silhavy Thomas J
Kinetic analysis of the assembly of the outer membrane protein LamB in Escherichia coli mutants each lacking a secretion or targeting factor in a different cellular compartment.
Journal of bacteriology 2007;189(2):446-54.
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2006: Gaal Tamas; Mandel Mark J; Silhavy Thomas J; Gourse Richard L
Crl facilitates RNA polymerase holoenzyme formation.
Journal of bacteriology 2006;188(22):7966-70.
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2006: Wu Tao; McCandlish Andrew C; Gronenberg Luisa S; Chng Shu-Sin; Silhavy Thomas J; Kahne Daniel
Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11754-9.
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2006: Ruiz Natividad; Wu Tao; Kahne Daniel; Silhavy Thomas J
Probing the barrier function of the outer membrane with chemical conditionality.
ACS chemical biology 2006;1(6):385-95.
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2006: Malinverni Juliana C; Werner John; Kim Seokhee; Sklar Joseph G; Kahne Daniel; Misra Rajeev; Silhavy Thomas J
YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli.
Molecular microbiology 2006;61(1):151-64.
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2006: Peterson Celeste N; Carabetta Valerie J; Chowdhury Tahmeena; Silhavy Thomas J
LrhA regulates rpoS translation in response to the Rcs phosphorelay system in Escherichia coli.
Journal of bacteriology 2006;188(9):3175-81.
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2006: Ruiz Natividad; Kahne Daniel; Silhavy Thomas J
Advances in understanding bacterial outer-membrane biogenesis.
Nature reviews. Microbiology 2006;4(1):57-66.
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2005: Isaac Daniel D; Pinkner Jerome S; Hultgren Scott J; Silhavy Thomas J
The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(49):17775-9.
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2005: Justice Sheryl S; Hunstad David A; Harper Jill Reiss; Duguay Amy R; Pinkner Jerome S; Bann James; Frieden Carl; Silhavy Thomas J; Hultgren Scott J
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli.
Journal of bacteriology 2005;187(22):7680-6.
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2005: Peterson Celeste N; Mandel Mark J; Silhavy Thomas J
Escherichia coli starvation diets: essential nutrients weigh in distinctly.
Journal of bacteriology 2005;187(22):7549-53.
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2005: Ruiz Natividad; Falcone Brian; Kahne Daniel; Silhavy Thomas J
Chemical conditionality: a genetic strategy to probe organelle assembly.
Cell 2005;121(2):307-17.
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2005: Wu Tao; Malinverni Juliana; Ruiz Natividad; Kim Seokhee; Silhavy Thomas J; Kahne Daniel
Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli.
Cell 2005;121(2):235-45.
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2005: Ruiz Natividad; Silhavy Thomas J
Sensing external stress: watchdogs of the Escherichia coli cell envelope.
Current opinion in microbiology 2005;8(2):122-6.
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2005: Mandel Mark J; Silhavy Thomas J
Starvation for different nutrients in Escherichia coli results in differential modulation of RpoS levels and stability.
Journal of bacteriology 2005;187(2):434-42.
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2004: Duguay Amy R; Silhavy Thomas J
Quality control in the bacterial periplasm.
Biochimica et biophysica acta 2004;1694(1-3):121-34.
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2004: Batchelor Eric; Silhavy Thomas J; Goulian Mark
Continuous control in bacterial regulatory circuits.
Journal of bacteriology 2004;186(22):7618-25.
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2004: Peterson Celeste N; Ruiz Natividad; Silhavy Thomas J
RpoS proteolysis is regulated by a mechanism that does not require the SprE (RssB) response regulator phosphorylation site.
Journal of bacteriology 2004;186(21):7403-10.
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2004: Gibbs Karine A; Isaac Daniel D; Xu Jun; Hendrix Roger W; Silhavy Thomas J; Theriot Julie A
Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB.
Molecular microbiology 2004;53(6):1771-83.
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2004: Lee Yvonne M; DiGiuseppe Patricia A; Silhavy Thomas J; Hultgren Scott J
P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli.
Journal of bacteriology 2004;186(13):4326-37.
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2003: Hand Nicholas J; Silhavy Thomas J
Null mutations in a Nudix gene, ygdP, implicate an alarmone response in a novel suppression of hybrid jamming.
Journal of bacteriology 2003;185(22):6530-9.
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2003: Ruiz Natividad; Silhavy Thomas J
Constitutive activation of the Escherichia coli Pho regulon upregulates rpoS translation in an Hfq-dependent fashion.
Journal of bacteriology 2003;185(20):5984-92.
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2003: Bowers Christina Wilson; Lau Fion; Silhavy Thomas J
Secretion of LamB-LacZ by the signal recognition particle pathway of Escherichia coli.
Journal of bacteriology 2003;185(19):5697-705.
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2003: Shuman Howard A; Silhavy Thomas J
The art and design of genetic screens: Escherichia coli.
Nature reviews. Genetics 2003;4(6):419-31.
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2003: DiGiuseppe Patricia A; Silhavy Thomas J
Signal detection and target gene induction by the CpxRA two-component system.
Journal of bacteriology 2003;185(8):2432-40.
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2002: Duguay Amy Rizzitello; Silhavy Thomas J
Signal sequence mutations as tools for the characterization of LamB folding intermediates.
Journal of bacteriology 2002;184(24):6918-28.
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2002: Braun Martin; Silhavy Thomas J
Imp/OstA is required for cell envelope biogenesis in Escherichia coli.
Molecular microbiology 2002;45(5):1289-302.
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2002: Otto Karen; Silhavy Thomas J
Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2287-92.
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2001: Rizzitello A E; Harper J R; Silhavy T J
Genetic evidence for parallel pathways of chaperone activity in the periplasm of Escherichia coli.
Journal of bacteriology 2001;183(23):6794-800.
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2001: Ruiz N; Peterson C N; Silhavy T J
RpoS-dependent transcriptional control of sprE: regulatory feedback loop.
Journal of bacteriology 2001;183(20):5974-81.
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2001: Eggert U S; Ruiz N; Falcone B V; Branstrom A A; Goldman R C; Silhavy T J; Kahne D
Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin.
Science (New York, N.Y.) 2001;294(5541):361-4.
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2001: Langen G R; Harper J R; Silhavy T J; Howard S P
Absence of the outer membrane phospholipase A suppresses the temperature-sensitive phenotype of Escherichia coli degP mutants and induces the Cpx and sigma(E) extracytoplasmic stress responses.
Journal of bacteriology 2001;183(18):5230-8.
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2001: Hung D L; Raivio T L; Jones C H; Silhavy T J; Hultgren S J
Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili.
The EMBO journal 2001;20(7):1508-18.
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2001: Raivio T L; Silhavy T J
Periplasmic stress and ECF sigma factors.
Annual review of microbiology 2001;55():591-624.
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2000: Silhavy T J
Gene fusions.
Journal of bacteriology 2000;182(21):5935-8.
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2000: Raivio T L; Laird M W; Joly J C; Silhavy T J
Tethering of CpxP to the inner membrane prevents spheroplast induction of the cpx envelope stress response.
Molecular microbiology 2000;37(5):1186-97.
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2000: Gibson K E; Silhavy T J
SprE levels are growth phase regulated in a sigma(S)-dependent manner at the level of translation.
Journal of bacteriology 2000;182(14):4117-20.
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2000: Hand N J; Silhavy T J
A practical guide to the construction and use of lac fusions in Escherichia coli.
Methods in enzymology 2000;326():11-35.
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1999: Raivio T L; Popkin D L; Silhavy T J
The Cpx envelope stress response is controlled by amplification and feedback inhibition.
Journal of bacteriology 1999;181(17):5263-72.
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1999: Harris C R; Silhavy T J
Mapping an interface of SecY (PrlA) and SecE (PrlG) by using synthetic phenotypes and in vivo cross-linking.
Journal of bacteriology 1999;181(11):3438-44.
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1999: Raivio T L; Silhavy T J
The sigmaE and Cpx regulatory pathways: overlapping but distinct envelope stress responses.
Current opinion in microbiology 1999;2(2):159-65.
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1999: Gibson K E; Silhavy T J
The LysR homolog LrhA promotes RpoS degradation by modulating activity of the response regulator sprE.
Journal of bacteriology 1999;181(2):563-71.
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1998: Danese P N; Oliver G R; Barr K; Bowman G D; Rick P D; Silhavy T J
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
Journal of bacteriology 1998;180(22):5875-84.
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1998: Pratt L A; Silhavy T J
Crl stimulates RpoS activity during stationary phase.
Molecular microbiology 1998;29(5):1225-36.
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1998: Hsing W; Russo F D; Bernd K K; Silhavy T J
Mutations that alter the kinase and phosphatase activities of the two-component sensor EnvZ.
Journal of bacteriology 1998;180(17):4538-46.
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1998: Cosma C L; Crotwell M D; Burrows S Y; Silhavy T J
Folding-based suppression of extracytoplasmic toxicity conferred by processing-defective LamB.
Journal of bacteriology 1998;180(12):3120-30.
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1998: Danese P N; Silhavy T J
CpxP, a stress-combative member of the Cpx regulon.
Journal of bacteriology 1998;180(4):831-9.
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1997: Raivio T L; Silhavy T J
Transduction of envelope stress in Escherichia coli by the Cpx two-component system.
Journal of bacteriology 1997;179(24):7724-33.
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1997: Silhavy T J
Death by lethal injection.
Science (New York, N.Y.) 1997;278(5340):1085-6.
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1997: Jones C H; Danese P N; Pinkner J S; Silhavy T J; Hultgren S J
The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems.
The EMBO journal 1997;16(21):6394-406.
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1997: Hsing W; Silhavy T J
Function of conserved histidine-243 in phosphatase activity of EnvZ, the sensor for porin osmoregulation in Escherichia coli.
Journal of bacteriology 1997;179(11):3729-35.
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1997: Danese P N; Silhavy T J
The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli.
Genes & development 1997;11(9):1183-93.
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1996: Pratt L A; Hsing W; Gibson K E; Silhavy T J
From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli.
Molecular microbiology 1996;20(5):911-7.
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1996: Pratt L A; Silhavy T J
The response regulator SprE controls the stability of RpoS.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2488-92.
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1995: Cosma C L; Danese P N; Carlson J H; Silhavy T J; Snyder W B
Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses.
Molecular microbiology 1995;18(3):491-505.
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1995: Danese P N; Murphy C K; Silhavy T J
Multicopy suppression of cold-sensitive sec mutations in Escherichia coli.
Journal of bacteriology 1995;177(17):4969-73.
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1995: Kenney L J; Bauer M D; Silhavy T J
Phosphorylation-dependent conformational changes in OmpR, an osmoregulatory DNA-binding protein of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8866-70.
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1995: Pratt L A; Silhavy T J
Identification of base pairs important for OmpR-DNA interaction.
Molecular microbiology 1995;17(3):565-73.
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1995: Snyder W B; Davis L J; Danese P N; Cosma C L; Silhavy T J
Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway.
Journal of bacteriology 1995;177(15):4216-23.
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1995: Huie J L; Silhavy T J
Suppression of signal sequence defects and azide resistance in Escherichia coli commonly result from the same mutations in secA.
Journal of bacteriology 1995;177(12):3518-26.
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1995: Flower A M; Osborne R S; Silhavy T J
The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE.
The EMBO journal 1995;14(5):884-93.
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1995: Danese P N; Snyder W B; Cosma C L; Davis L J; Silhavy T J
The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP.
Genes & development 1995;9(4):387-98.
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1995: Snyder W B; Silhavy T J
Beta-galactosidase is inactivated by intermolecular disulfide bonds and is toxic when secreted to the periplasm of Escherichia coli.
Journal of bacteriology 1995;177(4):953-63.
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1994: Pratt L A; Silhavy T J
OmpR mutants specifically defective for transcriptional activation.
Journal of molecular biology 1994;243(4):579-94.
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1994: Flower A M; Doebele R C; Silhavy T J
PrlA and PrlG suppressors reduce the requirement for signal sequence recognition.
Journal of bacteriology 1994;176(18):5607-14.
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1993: Osborne R S; Silhavy T J
PrlA suppressor mutations cluster in regions corresponding to three distinct topological domains.
The EMBO journal 1993;12(9):3391-8.
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1993: Carlson J H; Silhavy T J
Signal sequence processing is required for the assembly of LamB trimers in the outer membrane of Escherichia coli.
Journal of bacteriology 1993;175(11):3327-34.
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1993: Russo F D; Slauch J M; Silhavy T J
Mutations that affect separate functions of OmpR the phosphorylated regulator of porin transcription in Escherichia coli.
Journal of molecular biology 1993;231(2):261-73.
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1992: Snyder W B; Silhavy T J
Enhanced export of beta-galactosidase fusion proteins in prlF mutants is Lon dependent.
Journal of bacteriology 1992;174(17):5661-8.
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1992: Bieker-Brady K; Silhavy T J
Suppressor analysis suggests a multistep, cyclic mechanism for protein secretion in Escherichia coli.
The EMBO journal 1992;11(9):3165-74.
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1992: Russo F D; Silhavy T J
Alpha: the Cinderella subunit of RNA polymerase.
The Journal of biological chemistry 1992;267(21):14515-8.
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1992: Geiger O; Russo F D; Silhavy T J; Kennedy E P
Membrane-derived oligosaccharides affect porin osmoregulation only in media of low ionic strength.
Journal of bacteriology 1992;174(4):1410-3.
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1991: Russo F D; Silhavy T J
EnvZ controls the concentration of phosphorylated OmpR to mediate osmoregulation of the porin genes.
Journal of molecular biology 1991;222(3):567-80.
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1991: Slauch J M; Russo F D; Silhavy T J
Suppressor mutations in rpoA suggest that OmpR controls transcription by direct interaction with the alpha subunit of RNA polymerase.
Journal of bacteriology 1991;173(23):7501-10.
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1991: Schatz P J; Bieker K L; Ottemann K M; Silhavy T J; Beckwith J
One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery.
The EMBO journal 1991;10(7):1749-57.
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1991: Misra R; Peterson A; Ferenci T; Silhavy T J
A genetic approach for analyzing the pathway of LamB assembly into the outer membrane of Escherichia coli.
The Journal of biological chemistry 1991;266(21):13592-7.
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1991: Slauch J M; Silhavy T J
cis-acting ompF mutations that result in OmpR-dependent constitutive expression.
Journal of bacteriology 1991;173(13):4039-48.
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1990: Bieker K L; Silhavy T J
The genetics of protein secretion in E. coli.
Trends in genetics : TIG 1990;6(10):329-34.
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1990: Bieker K L; Phillips G J; Silhavy T J
The sec and prl genes of Escherichia coli.
Journal of bioenergetics and biomembranes 1990;22(3):291-310.
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1990: Bieker K L; Silhavy T J
PrlA (SecY) and PrlG (SecE) interact directly and function sequentially during protein translocation in E. coli.
Cell 1990;61(5):833-42.
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1990: Phillips G J; Silhavy T J
Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli.
Nature 1990;344(6269):882-4.
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1990: Igo M M; Slauch J M; Silhavy T J
Signal transduction in bacteria: kinases that control gene expression.
The New biologist 1990;2(1):5-9.
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1989: Igo M M; Ninfa A J; Stock J B; Silhavy T J
Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor.
Genes & development 1989;3(11):1725-34.
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1989: Slauch J M; Silhavy T J
Genetic analysis of the switch that controls porin gene expression in Escherichia coli K-12.
Journal of molecular biology 1989;210(2):281-92.
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1989: Stader J; Gansheroff L J; Silhavy T J
New suppressors of signal-sequence mutations, prlG, are linked tightly to the secE gene of Escherichia coli.
Genes & development 1989;3(7):1045-52.
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1989: Igo M M; Ninfa A J; Silhavy T J
A bacterial environmental sensor that functions as a protein kinase and stimulates transcriptional activation.
Genes & development 1989;3(5):598-605.
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1989: Trun N J; Silhavy T J
PrlC, a suppressor of signal sequence mutations in Escherichia coli, can direct the insertion of the signal sequence into the membrane.
Journal of molecular biology 1989;205(4):665-76.
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1989: Bieker K L; Silhavy T J
PrlA is important for the translocation of exported proteins across the cytoplasmic membrane of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):968-72.
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1988: Igo M M; Silhavy T J
EnvZ, a transmembrane environmental sensor of Escherichia coli K-12, is phosphorylated in vitro.
Journal of bacteriology 1988;170(12):5971-3.
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1988: Trun N J; Stader J; Lupas A; Kumamoto C; Silhavy T J
Two cellular components, PrlA and SecB, that recognize different sequence determinants are required for efficient protein export.
Journal of bacteriology 1988;170(12):5928-30.
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1988: Stader J; Silhavy T J
A progenitor of the outer membrane LamB trimer.
Journal of bacteriology 1988;170(4):1973-4.
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1988: Slauch J M; Garrett S; Jackson D E; Silhavy T J
EnvZ functions through OmpR to control porin gene expression in Escherichia coli K-12.
Journal of bacteriology 1988;170(1):439-41.
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1987: Ferenci T; Silhavy T J
Sequence information required for protein translocation from the cytoplasm.
Journal of bacteriology 1987;169(12):5339-42.
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1987: Rasmussen B A; Silhavy T J
The first 28 amino acids of mature LamB are required for rapid and efficient export from the cytoplasm.
Genes & development 1987;1(2):185-96.
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