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Janet Siliciano

Research Profile

Living Beings

Physiology

Disorders

Anatomy

CD4-Positive T-Lymphocytes

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Highly Active Antiretroviral Therapy

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Publications

TOP 3
Steven A Yukl; Christopher Bentsen; Eli Boritz; Michael Busch; Tae-Wook Chun; Daniel Douek; Evelyn Eisele; Ashley Haase; Ya-Chi Ho; Gero Hütter; J Shawn Justement; Sheila Keating; Tzong-Hae Lee; Peilin Li; Danielle Murray; Sarah Palmer; Christopher Pilcher; Satish Pillai; Richard W Price; Douglas Richman; Meghan Rothenberger; Timothy Schacker; Janet D Siliciano; Robert Siliciano; Elizabeth Sinclair; Matt Strain; Joseph Wong; Steven G Deeks
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
Susanne Eriksson; Erin H Graf; Frederick Hecht; Rebecca Hoh; Peter Hunt; Rowena Johnston; Jun Lai; Elena S Lysenko; Una O'Doherty; Sarah Palmer; Douglas D Richman; Mohamed Abdel-Mohsen; Ronald J Bosch; Stanley Chioma; Viktor Dahl; Steven G Deeks; Fatemeh Emad; Robert Siliciano; Ma Somsouk; Matthew C Strain; Joseph Wong; Steven A Yukl; Janet D Siliciano
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
Christine M Durand; Evelyn E Eisele; Joel E Gallant; Gabriel Ghiaur; Richard J Jones; Jun F Lai; Joseph B Margolick; S Alireza Rabi; Maria Salgado; Liang Shan; Janet D Siliciano; Richard F Ambinder; Hao Zhang; Robert Siliciano
HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.

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All Publications

2013: Steven A Yukl; Christopher Bentsen; Eli Boritz; Michael Busch; Tae-Wook Chun; Daniel Douek; Evelyn Eisele; Ashley Haase; Ya-Chi Ho; Gero Hütter; J Shawn Justement; Sheila Keating; Tzong-Hae Lee; Peilin Li; Danielle Murray; Sarah Palmer; Christopher Pilcher; Satish Pillai; Richard W Price; Douglas Richman; Meghan Rothenberger; Timothy Schacker; Janet D Siliciano; Robert Siliciano; Elizabeth Sinclair; Matt Strain; Joseph Wong; Steven G Deeks
Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
PLoS pathogens 2013;9(5):e1003347.
2013: Susanne Eriksson; Erin H Graf; Frederick Hecht; Rebecca Hoh; Peter Hunt; Rowena Johnston; Jun Lai; Elena S Lysenko; Una O'Doherty; Sarah Palmer; Douglas D Richman; Mohamed Abdel-Mohsen; Ronald J Bosch; Stanley Chioma; Viktor Dahl; Steven G Deeks; Fatemeh Emad; Robert Siliciano; Ma Somsouk; Matthew C Strain; Joseph Wong; Steven A Yukl; Janet D Siliciano
Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies.
PLoS pathogens 2013;9(2):e1003174.
2012: Christine M Durand; Evelyn E Eisele; Joel E Gallant; Gabriel Ghiaur; Richard J Jones; Jun F Lai; Joseph B Margolick; S Alireza Rabi; Maria Salgado; Liang Shan; Janet D Siliciano; Richard F Ambinder; Hao Zhang; Robert Siliciano
HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretroviral therapy.
The Journal of infectious diseases 2012;205(6):1014-8.
2011: Sifei Xing; Cynthia K Bullen; Neeta S Shroff; Liang Shan; Hung-Chih Yang; Jordyn L Manucci; Shridhar Bhat; Hao Zhang; Joseph B Margolick; Thomas C Quinn; David M Margolis; Janet D Siliciano; Robert Siliciano
Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
Journal of virology 2011;85(12):6060-4.
2011: Liang Shan; Hung-Chih Yang; S Alireza Rabi; Hector C Bravo; Neeta S Shroff; Rafael A Irizarry; Hao Zhang; Joseph B Margolick; Janet D Siliciano; Robert Siliciano
Influence of host gene transcription level and orientation on HIV-1 latency in a primary-cell model.
Journal of virology 2011;85(11):5384-93.
2011: Moira A McMahon; Teresa Parsons; Lin Shen; Janet D Siliciano; Robert Siliciano
Consistent inhibition of HIV-1 replication in CD4+ T cells by acyclovir without detection of human herpesviruses.
Journal of virology 2011;85(9):4618-22.
2010: Janet D Siliciano; Robert Siliciano
Biomarkers of HIV replication.
Current opinion in HIV and AIDS 2010;5(6):491-7.
2010: Joseph B Margolick; Hejab Imteyaz; Joel E Gallant; Susan J Langan; Jason B Dinoso; Janet D Siliciano; Joel N Blankson; Tricia L Nilles; Kendall A Smith; LINDA APUZZO
Prolonged viral suppression without therapy in an HIV-1 seroconverter following early antiretroviral therapy and daily interleukin-2.
AIDS (London, England) 2010;24(6):932-5.
2010: Moira A McMahon; Janet D Siliciano; Rahul Kohli; Robert Siliciano
Sensitivity of V75I HIV-1 reverse transcriptase mutant selected in vitro by acyclovir to anti-HIV drugs.
AIDS (London, England) 2010;24(2):319-23.
2010: Rajesh T Gandhi; Ronald J Bosch; Evgenia Aga; Mary Albrecht; Lisa M Demeter; Carrie Dykes; Barbara Bastow; Michael Para; Jun Lai; Robert Siliciano; Janet D Siliciano; Joseph J Eron
No evidence for decay of the latent reservoir in HIV-1-infected patients receiving intensive enfuvirtide-containing antiretroviral therapy.
The Journal of infectious diseases 2010;201(2):293-6.
2009: Timothy P Brennan; John O Woods; Ahmad R Sedaghat; Janet D Siliciano; Robert Siliciano; Claus O Wilke
Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy.
Journal of virology 2009;83(17):8470-81.
2009: Megan Wind-Rotolo; Christine Durand; Lisa Cranmer; Alison Reid; Neil A Martinson; Meg C Doherty; Benjamin L Jilek; Joseph Kagaayi; Allan Kizza; Visva Pillay; Oliver Laeyendecker; Steven J Reynolds; Susan H Eshleman; Bryan Lau; Stuart C Ray; Janet D Siliciano; Thomas C Quinn; Robert Siliciano
Identification of nevirapine-resistant HIV-1 in the latent reservoir after single-dose nevirapine to prevent mother-to-child transmission of HIV-1.
The Journal of infectious diseases 2009;199(9):1301-9.
2008: Moira A McMahon; Janet D Siliciano; Jun Lai; Jun O Liu; James T Stivers; Robert Siliciano; Rahul Kohli
The antiherpetic drug acyclovir inhibits HIV replication and selects the V75I reverse transcriptase multidrug resistance mutation.
The Journal of biological chemistry 2008;283(46):31289-93.
2008: Yefei Han; Yijie B Lin; Wenfeng An; Jie Xu; Hung-Chih Yang; Karen O'Connell; Dominic Dordai; Jef Boeke; Janet D Siliciano; Robert Siliciano
Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough.
Cell host & microbe 2008;4(2):134-46.
2008: Shiv K Gandhi; Janet D Siliciano; Justin R Bailey; Robert Siliciano; Joel N Blankson
Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors.
Journal of virology 2008;82(6):3125-30.
2007: Ahmad R Sedaghat; Janet D Siliciano; Timothy P Brennan; Claus O Wilke; Robert Siliciano
Limits on replenishment of the resting CD4+ T cell reservoir for HIV in patients on HAART.
PLoS pathogens 2007;3(8):e122.
2007: Janet D Siliciano; Jun Lai; Marc Callender; Eleanor Pitt; Hao Zhang; Joseph B Margolick; Joel E Gallant; Joseph Cofrancesco; Richard D Moore; Stephen J Gange; Robert Siliciano
Stability of the latent reservoir for HIV-1 in patients receiving valproic acid.
The Journal of infectious diseases 2007;195(6):833-6.
2007: Joel N Blankson; Justin R Bailey; Seema Thayil; Hung-Chih Yang; Kara G Lassen; Jun Lai; Shiv K Gandhi; Janet D Siliciano; Thomas M Williams; Robert Siliciano
Isolation and characterization of replication-competent human immunodeficiency virus type 1 from a subset of elite suppressors.
Journal of virology 2007;81(5):2508-18.
2007: Yefei Han; Megan Wind-Rotolo; Hung-Chih Yang; Janet D Siliciano; Robert Siliciano
Experimental approaches to the study of HIV-1 latency.
Nature reviews. Microbiology 2007;5(2):95-106.
2006: Justin R Bailey; Ahmad R Sedaghat; Tara L Kieffer; Timothy Brennan; Patricia K Lee; Megan Wind-Rotolo; Christine M Haggerty; Ashrit R Kamireddi; Yi Liu; Jessica Lee; Deborah Persaud; Joel E Gallant; Joseph Cofrancesco; Thomas C Quinn; Claus O Wilke; Stuart C Ray; Janet D Siliciano; Richard E Nettles; Robert Siliciano
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells.
Journal of virology 2006;80(13):6441-57.
2006: Janet D Siliciano; Robert Siliciano
The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure.
Current opinion in HIV and AIDS 2006;1(2):121-8.
2005: Janet D Siliciano; Robert Siliciano
Targeting HIV reservoirs with valproic acid.
The Hopkins HIV report : a bimonthly newsletter for healthcare providers / Johns Hopkins University AIDS Service 2005;17(5):8-9.
2005: Joel N Blankson; Janet D Siliciano; Robert Siliciano
The Effect of early treatment on the latent reservoir of HIV-1.
The Journal of infectious diseases 2005;191(9):1394-6.
2005: Yan Zhou; Haili Zhang; Janet D Siliciano; Robert Siliciano
Kinetics of human immunodeficiency virus type 1 decay following entry into resting CD4+ T cells.
Journal of virology 2005;79(4):2199-210.
2005: Janet D Siliciano; Robert Siliciano
Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals.
Methods in molecular biology (Clifton, N.J.) 2005;304():3-15.
2004: Kara G Lassen; Yefei Han; Yan Zhou; Janet D Siliciano; Robert Siliciano
The multifactorial nature of HIV-1 latency.
Trends in molecular medicine 2004;10(11):525-31.
2004: Janet D Siliciano; Robert Siliciano
A long-term latent reservoir for HIV-1: discovery and clinical implications.
The Journal of antimicrobial chemotherapy 2004;54(1):6-9.
2004: Yefei Han; Kara G Lassen; Daphne Monie; Ahmad R Sedaghat; Shino Shimoji; Xiao Liu; Theodore C Pierson; Joseph B Margolick; Robert Siliciano; Janet D Siliciano
Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genes.
Journal of virology 2004;78(12):6122-33.
2004: Haili Zhang; Yan Zhou; Cecily Alcock; Tara Kiefer; Daphne Monie; Janet D Siliciano; Quan Li; Paul A Pham; Joseph Cofrancesco; Deborah Persaud; Robert Siliciano
Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1.
Journal of virology 2004;78(4):1718-29.
2003: Monika Hermankova; Janet D Siliciano; Yan Zhou; Daphne Monie; Karen Chadwick; Joseph B Margolick; Thomas C Quinn; Robert Siliciano
Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo.
Journal of virology 2003;77(13):7383-92.
2003: Janet D Siliciano; Joleen Kajdas; Diana Finzi; Thomas C Quinn; Karen Chadwick; Joseph B Margolick; Colin Kovacs; Stephen J Gange; Robert Siliciano
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.
Nature medicine 2003;9(6):727-8.
2003: Deborah Persaud; Yan Zhou; Janet D Siliciano; Robert Siliciano
Latency in human immunodeficiency virus type 1 infection: no easy answers.
Journal of virology 2003;77(3):1659-65.
2002: Jesús Saavedra-Lozano; Cynthia McCoig; Jinbo Xu; Yanying Cao; Philip Keiser; Victor Ghetie; Robert Siliciano; Janet D Siliciano; Louis J Picker; Octavio Ramilo; Ellen S Vitetta
An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons.
The Journal of infectious diseases 2002;185(3):306-14.
2001: Monika Hermankova; Stuart C Ray; Christian T Ruff; M Powell-Davis; Roxann G Ingersoll; R T D'Aquila; Thomas C Quinn; Janet D Siliciano; Robert Siliciano; Deborah Persaud
HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy.
JAMA : the journal of the American Medical Association 2001;286(2):196-207.
2000: Anding Shen; Janet D Siliciano; Theodore C Pierson; Christopher Buck; Robert Siliciano
Establishment of latent HIV-1 infection of resting CD4(+) T lymphocytes does not require inactivation of Vpr.
Virology 2000;278(1):227-33.
2000: Janet D Siliciano; Robert Siliciano
Latency and viral persistence in HIV-1 infection.
The Journal of clinical investigation 2000;106(7):823-5.
2000: Theodore C Pierson; Trevor L Hoffman; Joel N Blankson; Diana Finzi; Karen Chadwick; Joseph B Margolick; Christopher Buck; Janet D Siliciano; R W Doms; Robert Siliciano
Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.
Journal of virology 2000;74(17):7824-33.
1999: Diana Finzi; Joel N Blankson; Janet D Siliciano; Joseph B Margolick; Karen Chadwick; Theodore C Pierson; K Smith; Julianna Lisziewicz; F Lori; Charles Flexner; Thomas C Quinn; Richard E Chaisson; E Rosenberg; B Walker; Stephen J Gange; Joel E Gallant; Robert Siliciano
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy.
Nature medicine 1999;5(5):512-7.
1998: Shilpy Sharma; Dae-Sik Lim; Karlene A Cimprich; Y Taya; Katsuyuki Tamai; K Sakaguchi; E Appella; Michael B Kastan; Janet D Siliciano
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53.
Science (New York, N.Y.) 1998;281(5383):1677-9.
1997: Janet D Siliciano; Shilpy Sharma; Y Taya; K Sakaguchi; E Appella; Michael B Kastan
DNA damage induces phosphorylation of the amino terminus of p53.
Genes & development 1997;11(24):3471-81.
1994: E M Janis; Janet D Siliciano; D D Isaac; Constance A Griffin; Anita L Hawkins; C A Kozak; Stephen Desiderio
Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
Genomics 1994;23(1):269-71.
1994: Stephen Desiderio; Janet D Siliciano
The Itk/Btk/Tec family of protein-tyrosine kinases.
Chemical immunology 1994;59():191-210.
1992: Janet D Siliciano; T A Morrow; Stephen Desiderio
itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(23):11194-8.
1988: Janet D Siliciano; Daniel A Goodenough
Localization of the tight junction protein, ZO-1, is modulated by extracellular calcium and cell-cell contact in Madin-Darby canine kidney epithelial cells.
The Journal of cell biology 1988;107(6 Pt 1):2389-99.
1987: Janet D Siliciano; Susan W Craig
Properties of smooth muscle meta-vinculin.
The Journal of cell biology 1987;104(3):473-82.
1986: Bruce R Stevenson; Janet D Siliciano; Mark S Mooseker; Daniel A Goodenough
Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.
The Journal of cell biology 1986;103(3):755-66.
1986: Janet D Siliciano; Susan W Craig
Isolation of metavinculin from chicken smooth muscle.
Methods in enzymology 1986;134():78-85.
1983: Jose Pardo; Janet D Siliciano; Susan W Craig
Vinculin is a component of an extensive network of myofibril-sarcolemma attachment regions in cardiac muscle fibers.
The Journal of cell biology 1983;97(4):1081-8.
1983: Jose Pardo; Janet D Siliciano; Susan W Craig
A vinculin-containing cortical lattice in skeletal muscle: transverse lattice elements ("costameres") mark sites of attachment between myofibrils and sarcolemma.
Proceedings of the National Academy of Sciences of the United States of America 1983;80(4):1008-12.
1982: Janet D Siliciano; Susan W Craig
Meta-vinculin--a vinculin-related protein with solubility properties of a membrane protein.
Nature 1982;300(5892):533-5.