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Giuliano Siligardi

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TOP 3
Ruoyan Xu; David G Fernig; Ashley J Hughes; Timothy R Rudd; Giuliano Siligardi; Edwin A Yates
Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network.
Kim E Bettaney; Peter J F Henderson; Rohanah Hussain; Giuliano Siligardi; Preethi Sukumar; Simon G Patching
A systematic approach to the amplified expression, functional characterization and purification of inositol transporters from Bacillus subtilis.
Mary K Phillips-Jones; Shalini Edara; Rohanah Hussain; Jiro Nakayama; Simon G Patching; Giuliano Siligardi
Interactions of the intact FsrC membrane histidine kinase with the tricyclic peptide inhibitor siamycin I revealed through synchrotron radiation circular dichroism.

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All Publications

2013: Ruoyan Xu; David G Fernig; Ashley J Hughes; Timothy R Rudd; Giuliano Siligardi; Edwin A Yates
Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network.
The FEBS journal 2013;280(10):2260-70.
2013: Kim E Bettaney; Peter J F Henderson; Rohanah Hussain; Giuliano Siligardi; Preethi Sukumar; Simon G Patching
A systematic approach to the amplified expression, functional characterization and purification of inositol transporters from Bacillus subtilis.
Molecular membrane biology 2013;30(1):3-14.
2013: Mary K Phillips-Jones; Shalini Edara; Rohanah Hussain; Jiro Nakayama; Simon G Patching; Giuliano Siligardi
Interactions of the intact FsrC membrane histidine kinase with the tricyclic peptide inhibitor siamycin I revealed through synchrotron radiation circular dichroism.
Physical chemistry chemical physics : PCCP 2013;15(2):444-7.
2012: Ruoyan Xu; Edwin A Yates; Yassir A Ahmed; Scott E Guimond; Alessandro Ori; Timothy R Rudd; Giuliano Siligardi; Mark A Skidmore; Katarzyna A Uniewicz; David G Fernig
Diversification of the structural determinants of fibroblast growth factor-heparin interactions: implications for binding specificity.
The Journal of biological chemistry 2012;287(47):40061-73.
2012: Ashley J Hughes; Rohanah Hussain; Cesare Cosentino; Marco Guerrini; Giuliano Siligardi; Edwin A Yates; Timothy R Rudd
A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation.
Biochemical and biophysical research communications 2012;425(4):794-9.
2012: Simon G Patching; Giuliano Siligardi; Shalini Edara; Rohanah Hussain; Pikyee Ma; Jiro Nakayama; Mary K Phillips-Jones
Interactions of the intact FsrC membrane histidine kinase with its pheromone ligand GBAP revealed through synchrotron radiation circular dichroism.
Biochimica et biophysica acta 2012;1818(7):1595-602.
2012: Giuliano Siligardi; Anna Maria Brunati; Luca Cesaro; Rohanah Hussain; Lorenzo A Pinna; Paolo Ruzza; Arianna Donella-Deana
The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs.
Amino acids 2012;42(4):1361-70.
2011: Stefania Laera; Francois Rossi; Giuliano Siligardi; Giacomo Ceccone; Douglas Gilliland; Rohanah Hussain; Luigi Calzolai
Measuring protein structure and stability of protein-nanoparticle systems with synchrotron radiation circular dichroism.
Nano letters 2011;11(10):4480-4.
2011: Jonathan R Burns; Rohanah Hussain; Giuliano Siligardi; Jurgita Zekonyte; Eugen Stulz
Directed formation of DNA nanoarrays through orthogonal self-assembly.
Molecules (Basel, Switzerland) 2011;16(6):4912-22.
2010: Tim Rudd; Katarzyna A Uniewicz; Alessandro Ori; Scott E Guimond; Mark A Skidmore; Davide Gaudesi; Ruoyan Xu; Jeremy E Turnbull; marco Guerrini; Giangiacomo Torri; Giuliano Siligardi; Mark C Wilkinson; David G Fernig; Edwin A Yates
Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships.
Organic & biomolecular chemistry 2010;8(23):5390-7.
2010: Tim Rudd; M A Skidmore; M Guerrini; M Hricovini; A K Powell; Giuliano Siligardi; E A Yates
The conformation and structure of GAGs: recent progress and perspectives.
Current opinion in structural biology 2010;20(5):567-74.
2010: Mohan B Rajasekaran; Sue A Mitchell; Trevor M Gibson; Rohanah Hussain; Giuliano Siligardi; Simon C Andrews; Kimberly A Watson
Isolation and characterisation of EfeM, a periplasmic component of the putative EfeUOBM iron transporter of Pseudomonas syringae pv. syringae.
Biochemical and biophysical research communications 2010;398(3):366-71.
2010: Tim Rudd; Rohanah Hussain; Giuliano Siligardi; Edwin A Yates
Raman and Raman optical activity of glycosaminoglycans.
Chemical communications (Cambridge, England) 2010;46(23):4124-6.
2010: Ian W Hamley; Valeria Castelletto; Claire Moulton; Daniel Myatt; Giuliano Siligardi; Cristiano L P Oliveira; Jan Skov Pedersen; Inbal Abutbul; Dganit Danino
Self-assembly of a modified amyloid peptide fragment: pH-responsiveness and nematic phase formation.
Macromolecular bioscience 2010;10(1):40-8.
2010: Daniel Myatt; Louise Johnson; Sonja Baumli; Giuliano Siligardi
The binding of flavopiridol to blood serum albumin.
Chirality 2010;22 Suppl 1():E40-3.
2010: Tamás Jávorfi; Rohanah Hussain; Daniel Myatt; Giuliano Siligardi
Measuring circular dichroism in a capillary cell using the b23 synchrotron radiation CD beamline at diamond light source.
Chirality 2010;22 Suppl 1():E149-53.
2010: Rohanah Hussain; Giuliano Siligardi
Novel drug delivery system for lipophilic therapeutics of small molecule, peptide-based and protein drugs.
Chirality 2010;22 Suppl 1():E44-6.
2010: Chiara Rubini; Paolo Ruzza; Mark R Spaller; Giuliano Siligardi; Rohanah Hussain; D Gomika Udugamasooriya; Massimo Bellanda; Stefano Mammi; Andrea Borgogno; Andrea Calderan; Luca Cesaro; Anna M Brunati; Arianna Donella-Deana
Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.
Biopolymers 2010;94(3):298-306.
2009: Paolo Ruzza; Chiara Rubini; Giuliano Siligardi; Rohanah Hussain; Andrea Calderan; Andrea Guiotto; Luca Cesaro; Anna M Brunati; Arianna Donella-Deana
Effect of 4-fluoro-L-proline on the SH3 binding affinity.
Advances in experimental medicine and biology 2009;611():499-500.
2009: Paolo Ruzza; Chiara Rubini; Giuliano Siligardi; Rohanah Hussain; Andrea Calderan; Andrea Guiotto; Luca Cesaro; Anna M Brunati; Arianna Donella-Deana
Introduction of N-alkyl residues in proline-rich peptides: effect on SH3 binding affinity and peptide conformation.
Advances in experimental medicine and biology 2009;611():65-6.
2006: Robert Cheng; Martin E M Noble; Vicky Skamnaki; Nick R Brown; Edward D Lowe; Luke Kontogiannis; Kui Shen; Philip A Cole; Giuliano Siligardi; Louise N Johnson
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
The Journal of biological chemistry 2006;281(32):23167-79.
2006: Paolo Ruzza; Giuliano Siligardi; Arianna Donella-Deana; Andrea Calderan; Rohanah Hussain; Chiara Rubini; Luca Cesaro; Alessio Osler; Andrea Guiotto; Lorenzo A Pinna; Gianfranco Borin
4-Fluoroproline derivative peptides: effect on PPII conformation and SH3 affinity.
Journal of peptide science : an official publication of the European Peptide Society 2006;12(7):462-71.
2004: Giuliano Siligardi; Bin Hu; Barry Panaretou; Peter W Piper; Laurence H Pearl; Chrisostomos Prodromou
Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle.
The Journal of biological chemistry 2004;279(50):51989-98.
2004: Daniel S Chapple; Rohanah Hussain; Christopher L Joannou; Robert E W Hancock; Edward W Odell; Robert W Evans; Giuliano Siligardi
Structure and association of human lactoferrin peptides with Escherichia coli lipopolysaccharide.
Antimicrobial agents and chemotherapy 2004;48(6):2190-8.
2003: Peter W Piper; Stefan H Millson; Mehdi Mollapour; Barry Panaretou; Giuliano Siligardi; Laurence H Pearl; Chrisostomos Prodromou
Sensitivity to Hsp90-targeting drugs can arise with mutation to the Hsp90 chaperone, cochaperones and plasma membrane ATP binding cassette transporters of yeast.
European journal of biochemistry / FEBS 2003;270(23):4689-95.
2002: Barry Panaretou; Giuliano Siligardi; Philippe Meyer; Alison Maloney; Janis K Sullivan; Shradha Singh; Stefan H Millson; Paul A Clarke; Soren Naaby-Hansen; Rob Stein; Rainer Cramer; Mehdi Mollapour; Paul Workman; Peter W Piper; Laurence H Pearl; Chrisostomos Prodromou
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.
Molecular cell 2002;10(6):1307-18.
2002: Giuliano Siligardi; Barry Panaretou; Philippe Meyer; Shradha Singh; Derek N Woolfson; Peter W Piper; Laurence H Pearl; Chrisostomos Prodromou
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.
The Journal of biological chemistry 2002;277(23):20151-9.
2001: L M Alexander McNamara; M J Andrews; F Mitzel; Giuliano Siligardi; Alethea B Tabor
Peptides constrained by an aliphatic linkage between two C(alpha) sites: design, synthesis, and unexpected conformational properties of an i,(i + 4)-linked peptide.
The Journal of organic chemistry 2001;66(13):4585-94.
2000: Chrisostomos Prodromou; Barry Panaretou; S Chohan; Giuliano Siligardi; Ronan O'Brien; John E Ladbury; S Mark Roe; Peter W Piper; Laurence H Pearl
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains.
The EMBO journal 2000;19(16):4383-92.
2000: C P Smyth; T Lundbäck; D Renzoni; Giuliano Siligardi; R Beavil; M Layton; J M Sidebotham; Jay Hinton; Paul C Driscoll; Christopher F Higgins; John E Ladbury
Oligomerization of the chromatin-structuring protein H-NS.
Molecular microbiology 2000;36(4):962-72.
2000: Bernard O'Hara; S A Wilson; A W Lee; S Mark Roe; Giuliano Siligardi; RE Drew; Laurence H Pearl
Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC.
Protein engineering 2000;13(2):129-32.
1999: Chrisostomos Prodromou; Giuliano Siligardi; Ronan O'Brien; Derek N Woolfson; L Regan; Barry Panaretou; John E Ladbury; Peter W Piper; Laurence H Pearl
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones.
The EMBO journal 1999;18(3):754-62.
1998: Giuliano Siligardi; R Hussain
Biomolecules interactions and competitions by non-immobilised ligand interaction assay by circular dichroism.
Enantiomer 1998;3(2):77-87.
1997: SJ Awan; Giuliano Siligardi; Peter M Shoolingin-Jordan; Martin J Warren
Reconstitution of the holoenzyme form of Escherichia coli porphobilinogen deaminase from apoenzyme with porphobilinogen and preuroporphyrinogen: a study using circular dichroism spectroscopy.
Biochemistry 1997;36(30):9273-82.
1997: SJ Awan; Giuliano Siligardi; Martin J Warren; Peter M Shoolingin-Jordan
Discovery of a novel mechanism for cofactor assembly by Escherichia coli porphobilinogen deaminase.
Biochemical Society transactions 1997;25(1):79S.
1997: NM Senior; Giuliano Siligardi; A Drake; P G Thomas; Martin J Warren
Structural studies on 5-aminolaevulinic acid dehydratase from Saccharomyces cerevisiae (yeast).
Biochemical Society transactions 1997;25(1):78S.
1996: D Renzoni; D J Pugh; Giuliano Siligardi; P Das; CJ Morton; C Rossi; Michael D Waterfield; Iain D Campbell; John E Ladbury
Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.
Biochemistry 1996;35(49):15646-53.