FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

John Silke

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Anatomy

Cell Line

Phenomena

Protein Binding

Co-author Network

Publications

TOP 3
John Silke; Pascal Meier
Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation.
Ulrich Putz; John Silke; Anh Doan; Choo-Peng Goh; Jason Howitt; Ley-Hian Low; Seong-Seng Tan
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
Ueli Nachbur; Lorraine A O'Reilly; Andreas Strasser; James E Vince; John Silke
Is BID required for NOD signalling?

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of John Silke (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: John Silke; Pascal Meier
Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation.
Cold Spring Harbor perspectives in biology 2013;5(2):.
2012: Ulrich Putz; John Silke; Anh Doan; Choo-Peng Goh; Jason Howitt; Ley-Hian Low; Seong-Seng Tan
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
Science signaling 2012;5(243):ra70.
2012: Ueli Nachbur; Lorraine A O'Reilly; Andreas Strasser; James E Vince; John Silke
Is BID required for NOD signalling?
Nature 2012;488(7412):E4-6; discussion E6-8.
2012: Rune Busk Damgaard; Berthe Katrine Fiil; Aleksandra Bankovacki; Simon Bekker-Jensen; Philipp J Jost; Mischa Kastirr; Thomas Kaufmann; Niels Mailand; Ueli Nachbur; Christian Peschel; James Arthur Rickard; Eva Rieser; Juergen Ruland; John Silke; Andreas Strasser; Henning Walczak; Wendy Wei-Lynn Wong; Monica Yabal; Mads Gyrd-Hansen
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Molecular cell 2012;46(6):746-58.
2012: Jenny Lackovic; John Silke; Perry Bartlett; Jennifer K Callaway; Jason Howitt; Seong-Seng Tan
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke.
Experimental neurology 2012;235(1):326-35.
2012: Rebecca Feltham; Nufail Khan; John Silke
IAPS and ubiquitylation.
IUBMB life 2012;64(5):411-8.
2012: J J Sandow; John Silke; Frank C Stomski; M R Condina; C P Daunt; B D Green; Mark A Guthridge; P Hoffmann; Anissa M Jabbour; Angel F Lopez; Christopher D Riffkin; Paul G Ekert
Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death.
Cell death and differentiation 2012;19(4):633-41.
2012: James E Vince; W Wei-Lynn Wong; Ramanjaneyulu Allam; Holly Anderton; Rosa Castillo; Ian Gentle; Olaf Gross; Greta Guarda; Georg Häcker; Kate E Lawlor; Stephen Ma; Kylie Mason; Lorraine O'Reilly; John Silke; Jürg Tschopp
Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.
Immunity 2012;36(2):215-27.
2011: John Silke
The regulation of TNF signalling: what a tangled web we weave.
Current opinion in immunology 2011;23(5):620-6.
2011: M Darding; R Feltham; Christopher A Benetatos; K Bianchi; John Silke; Tencho Tenev; Pascal Meier
Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2.
Cell death and differentiation 2011;18(8):1376-86.
2011: Rebecca Feltham; Bodhi Bettjeman; Rhesa Budhidarmo; Peter D Mace; Sarah Shirley; Stephen M Condon; Srinivas K Chunduru; Mark A McKinlay; David L Vaux; John Silke; Catherine L Day
Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.
The Journal of biological chemistry 2011;286(19):17015-28.
2011: Ian Gentle; W Wei-Lynn Wong; Joseph M Evans; Alexandra Bankovacki; Wendy D Cook; Nufail R Khan; Ulrich Nachbur; James Rickard; Holly Anderton; Maryline Moulin; Josep Maria Lluis; Donia M Moujalled; John Silke; David L Vaux
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8.
The Journal of biological chemistry 2011;286(15):13282-91.
2011: Sandra Gardam; Vivian M Turner; Holly Anderton; Sandhya Limaye; Antony Basten; Frank Koentgen; David L Vaux; John Silke; Robert Brink
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Blood 2011;117(15):4041-51.
2011: Björn Gerlach; Stefanie M Cordier; Anna C Schmukle; Christoph H Emmerich; Eva Rieser; Tobias L Haas; Andrew I Webb; James A Rickard; Holly Anderton; Wendy W-L Wong; Ueli Nachbur; Lahiru Gangoda; Uwe Warnken; Anthony W Purcell; John Silke; Henning Walczak
Linear ubiquitination prevents inflammation and regulates immune signalling.
Nature 2011;471(7340):591-6.
2011: Ian Gentle; John Silke
New perspectives in TNF-R1-induced NF-κB signaling.
Advances in experimental medicine and biology 2011;691():79-88.
2011: John Silke; Domagoj Vucic
Workshop summary: novel aspects of the functions of the TRAFs and cIAPs.
Advances in experimental medicine and biology 2011;691():53-61.
2010: Meike Broemer; Tencho Tenev; Kristoffer T G Rigbolt; Sophie Hempel; Blagoy Blagoev; John Silke; Mark Ditzel; Pascal Meier
Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.
Molecular cell 2010;40(5):810-22.
2010: Yvonne Y C Yeap; Ivan H W Ng; Bahareh Badrian; Tuong-Vi Nguyen; Yan Y Yip; Amardeep S Dhillon; Steven E Mutsaers; John Silke; Marie A Bogoyevitch; Dominic C H Ng
c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18.
The Biochemical journal 2010;430(2):345-54.
2010: Rebecca Feltham; Maryline Moulin; James E Vince; Peter D Mace; Wendy Wei-Lynn Wong; Holly Anderton; Catherine L Day; David L Vaux; John Silke
Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.
The Journal of biological chemistry 2010;285(23):17525-36.
2010: W W-L Wong; Ian Gentle; U Nachbur; H Anderton; David L Vaux; John Silke
RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.
Cell death and differentiation 2010;17(3):482-7.
2010: Josep Maria Lluis; Ulrich Nachbur; Wendy Diane Cook; Ian Gentle; Donia Moujalled; Maryline Moulin; Wendy Wei-Lynn Wong; Nufail Khan; Diep Chau; Bernard A Callus; James Edward Vince; John Silke; David L Vaux
TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.
PloS one 2010;5(1):e8620.
2010: John Silke; R Brink
Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs.
Cell death and differentiation 2010;17(1):35-45.
2009: Peter Geserick; Mike Hupe; Maryline Moulin; W Wei-Lynn Wong; Maria Feoktistova; Beate Kellert; Harald Gollnick; John Silke; Martin Leverkus
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment.
The Journal of cell biology 2009;187(7):1037-54.
2009: James E Vince; Delara Pantaki; Rebecca Feltham; Peter D Mace; Stephanie M Cordier; Anna C Schmukle; Angelina J Davidson; Bernard A Callus; Wendy Wei-Lynn Wong; Ian Gentle; Holly Carter; Erinna Lee; Henning Walczak; Catherine L Day; David L Vaux; John Silke
TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.
The Journal of biological chemistry 2009;284(51):35906-15.
2009: W Wei-Lynn Wong; John Silke
Another facet of ubiquitylation: death.
Journal of molecular cell biology 2009;1(2):80-1.
2009: Philipp J Jost; Stephanie Grabow; Daniel Gray; Mark D McKenzie; Ueli Nachbur; David C S Huang; Philippe Bouillet; Helen E Thomas; Christoph Borner; John Silke; Andreas Strasser; Thomas Kaufmann
XIAP discriminates between type I and type II FAS-induced apoptosis.
Nature 2009;460(7258):1035-9.
2009: Thomas Kaufmann; Philipp J Jost; Marc Pellegrini; Hamsa Puthalakath; Raffi Gugasyan; Steve Gerondakis; Erika Cretney; Mark J Smyth; John Silke; Razq Hakem; Philippe Bouillet; Tak W Mak; Xiaodong Huang; Andreas Strasser
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.
Immunity 2009;30(1):56-66.
2009: Afsar U Ahmed; Maryline Moulin; Franck Coumailleau; W Wei-Lynn Wong; Maria Miasari; Holly Carter; John Silke; Michel Cohen-Tannoudji; James E Vince; David L Vaux
CARP2 deficiency does not alter induction of NF-kappaB by TNFalpha.
Current biology : CB 2009;19(1):R15-7; author reply R17-9.
2008: Bernard A Callus; Donia M Moujallad; John Silke; Robert Gerl; Anissa M Jabbour; Paul G Ekert; David L Vaux
Triggering of apoptosis by Puma is determined by the threshold set by prosurvival Bcl-2 family proteins.
Journal of molecular biology 2008;384(2):313-23.
2008: Mads Gyrd-Hansen; Maurice Darding; Maria Miasari; Massimo M Santoro; Lars Zender; Wen Xue; Tencho Tenev; Paula C A da Fonseca; Marketa Zvelebil; Janusz Bujnicki; Scott W Lowe; John Silke; Pascal Meier
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis.
Nature cell biology 2008;10(11):1309-17.
2008: James E Vince; Diep Chau; Bernard A Callus; W Wei-Lynn Wong; Christine J Hawkins; Pascal Schneider; Mark McKinlay; Christopher A Benetatos; Stephen M Condon; Srinivas K Chunduru; George Yeoh; Robert Brink; David L Vaux; John Silke
TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.
The Journal of cell biology 2008;182(1):171-84.
2008: Philip Diessenbacher; Mike Hupe; Martin Sprick; Andreas Kerstan; Peter Geserick; Tobias L Haas; Tina Wachter; Manfred Neumann; Henning Walczak; John Silke; Martin Leverkus
NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.
The Journal of investigative dermatology 2008;128(5):1134-47.
2008: Maria Miasari; Hamsa Puthalakath; John Silke
Ubiquitylation and cancer development.
Current cancer drug targets 2008;8(2):118-23.
2008: Bernard A Callus; Paul G Ekert; J E Heraud; Anissa M Jabbour; A Kotevski; James E Vince; John Silke; David L Vaux
Cytoplasmic p53 is not required for PUMA-induced apoptosis.
Cell death and differentiation 2008;15(1):213-5; author reply 215-6.
2007: James E Vince; W Wei-Lynn Wong; Nufail Khan; Rebecca Feltham; Diep Chau; Afsar U Ahmed; Christopher A Benetatos; Srinivas K Chunduru; Stephen M Condon; Mark McKinlay; Robert Brink; Martin Leverkus; Vinay Tergaonkar; Pascal Schneider; Bernard A Callus; Frank Koentgen; David L Vaux; John Silke
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.
Cell 2007;131(4):682-93.
2007: C J R Dunning; Matthew McKenzie; Canny Sugiana; Michael Lazarou; John Silke; A Connelly; J M Fletcher; Denise M Kirby; David R Thorburn; Michael T Ryan
Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease.
The EMBO journal 2007;26(13):3227-37.
2007: Marlyse A Debrincat; Jian-Guo Zhang; Tracy A Willson; John Silke; Lisa M Connolly; Richard J Simpson; Warren S Alexander; Nicos A Nicola; Benjamin T Kile; Douglas J Hilton
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.
The Journal of biological chemistry 2007;282(7):4728-37.
2007: Anne M Verhagen; Tobias Kratina; Christine J Hawkins; John Silke; Paul G Ekert; David L Vaux
Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs.
Cell death and differentiation 2007;14(2):348-57.
2006: James E Vince; John Silke
TWEAK shall inherit the earth.
Cell death and differentiation 2006;13(11):1842-4.
2006: Paul G Ekert; Anissa M Jabbour; Anand Manoharan; Jacki E Heraud; Jai Yu; Miha Pakusch; Ewa M Michalak; Priscilla N Kelly; Bernard A Callus; Thomas Kiefer; Anne Verhagen; John Silke; Andreas Strasser; Christoph Borner; David L Vaux
Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.
Blood 2006;108(5):1461-8.
2005: John Silke; Tobias Kratina; Diep Chu; Paul G Ekert; Catherine L Day; Miha Pakusch; David C S Huang; David L Vaux
Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(45):16182-7.
2005: D L Vaux; John Silke
IAPs--the ubiquitin connection.
Cell death and differentiation 2005;12(9):1205-7.
2005: David L Vaux; John Silke
IAPs, RINGs and ubiquitylation.
Nature reviews. Molecular cell biology 2005;6(4):287-97.
2004: Paul G Ekert; Stuart H Read; John Silke; Vanessa S Marsden; Hitto Kaufmann; Christine J Hawkins; Robert Gerl; Sharad Kumar; David L Vaux
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.
The Journal of cell biology 2004;165(6):835-42.
2004: John Silke; Tobias Kratina; Paul G Ekert; Miha Pakusch; David L Vaux
Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.
The Journal of biological chemistry 2004;279(6):4313-21.
2003: David L Vaux; John Silke
HtrA2/Omi, a sheep in wolf's clothing.
Cell 2003;115(3):251-3.
2003: David L Vaux; John Silke
Mammalian mitochondrial IAP binding proteins.
Biochemical and biophysical research communications 2003;304(3):499-504.
2002: Vanessa S Marsden; Liam O'Connor; Lorraine A O'Reilly; John Silke; Donald Metcalf; Paul G Ekert; David C S Huang; Francesco Cecconi; Keisuke Kuida; Kevin J Tomaselli; Sophie Roy; Don W Nicholson; David L Vaux; Philippe Bouillet; Jerry M Adams; Andreas Strasser
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome.
Nature 2002;419(6907):634-7.
2002: John Silke; Anne M Verhagen
Jekyll and Hyde; changing places, changing faces.
Cell death and differentiation 2002;9(4):362-3.
2002: John Silke; Christine J Hawkins; Paul G Ekert; Joanne Chew; Catherine L Day; Miha Pakusch; Anne M Verhagen; David L Vaux
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites.
The Journal of cell biology 2002;157(1):115-24.
2002: Anne M Verhagen; John Silke; Paul G Ekert; Miha Pakusch; Hitto Kaufmann; Lisa M Connolly; Catherine L Day; Anjali Tikoo; Richard Burke; Carolyn Wrobel; Robert L Moritz; Richard J Simpson; David L Vaux
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
The Journal of biological chemistry 2002;277(1):445-54.
2001: Christine J Hawkins; John Silke; Anne M Verhagen; R Foster; Paul G Ekert; David M Ashley
Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism.
Apoptosis : an international journal on programmed cell death 2001;6(5):331-8.
2001: Anne M Verhagen; Miha Pakusch; John Silke; David L Vaux
TNF and CD95 promote IL-8 gene transactivation via independent elements in colon carcinoma cells.
Cytokine 2001;15(2):108-12.
2001: Paul G Ekert; John Silke
Till death do us part.
Cell death and differentiation 2001;8(7):662-4.
2001: John Silke; Paul G Ekert; Catherine L Day; Christine J Hawkins; Manuel Baca; J Chew; Miha Pakusch; Anne M Verhagen; David L Vaux
Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP.
The EMBO journal 2001;20(12):3114-23.
2001: John Silke; David L Vaux
Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis.
Journal of cell science 2001;114(Pt 10):1821-7.
2001: Paul G Ekert; John Silke; Christine J Hawkins; Anne M Verhagen; David L Vaux
DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9.
The Journal of cell biology 2001;152(3):483-90.
2000: John Silke; Anne M Verhagen; Paul G Ekert; David L Vaux
Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid?
Cell death and differentiation 2000;7(12):1275.
2000: Anne M Verhagen; Paul G Ekert; Miha Pakusch; John Silke; Lisa M Connolly; Gavin E Reid; Robert L Moritz; Richard J Simpson; David L Vaux
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Cell 2000;102(1):43-53.
1999: Paul G Ekert; John Silke; David L Vaux
Caspase inhibitors.
Cell death and differentiation 1999;6(11):1081-6.
1999: Paul G Ekert; John Silke; David L Vaux
Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors.
The EMBO journal 1999;18(2):330-8.
1998: John Silke; David L Vaux
Cell death: shadow baxing.
Current biology : CB 1998;8(15):R528-31.