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Graeme Sills

Research Profile

Chemicals & Drugs

Disorders

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Anatomy

Brain

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Drug Therapy, Combination

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Publications

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Martin J Brodie; Athanasios Covanis; Antonio Gil-Nagel; Holger Lerche; Emilio Perucca; Graeme J Sills; H Steve White
Antiepileptic drug therapy: does mechanism of action matter?
Martin J Brodie; Graeme J Sills
Combining antiepileptic drugs--rational polytherapy?
Pedro Gonzalez; Graeme J Sills; Stuart Parks; Kevin Kelly; Linda J Stephen; David Keating; Gordon N Dutton; Martin J Brodie
Binasal visual field defects are not specific to vigabatrin.

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All Publications

2011: Martin J Brodie; Athanasios Covanis; Antonio Gil-Nagel; Holger Lerche; Emilio Perucca; Graeme J Sills; H Steve White
Antiepileptic drug therapy: does mechanism of action matter?
Epilepsy & behavior : E&B 2011;21(4):331-41.
2011: Martin J Brodie; Graeme J Sills
Combining antiepileptic drugs--rational polytherapy?
Seizure : the journal of the British Epilepsy Association 2011;20(5):369-75.
2009: Pedro Gonzalez; Graeme J Sills; Stuart Parks; Kevin Kelly; Linda J Stephen; David Keating; Gordon N Dutton; Martin J Brodie
Binasal visual field defects are not specific to vigabatrin.
Epilepsy & behavior : E&B 2009;16(3):521-6.
2009: Stuart Cain; Torsten Ruest; Sally Pimlott; Jim Patterson; Rod Duncan; Debbie Dewar; Graeme J Sills
High resolution micro-SPECT scanning in rats using 125I beta-CIT: effects of chronic treatment with carbamazepine.
Epilepsia 2009;50(8):1962-70.
2009: Mohd Makmor-Bakry; Graeme J Sills; Nikolas Hitiris; Elaine Butler; Elaine A Wilson; Martin J Brodie
Genetic variants in microsomal epoxide hydrolase influence carbamazepine dosing.
Clinical neuropharmacology 2009;32(4):205-12.
2009: Cassandra Szoeke; Graeme J Sills; Patrick Kwan; Slave Petrovski; Mark Newton; Nikolas Hitiris; Larry Baum; Samuel F Berkovic; Martin J Brodie; Leslie J Sheffield; Terence J O'Brien
Multidrug-resistant genotype (ABCB1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts.
Epilepsia 2009;50(7):1689-96.
2007: Nikolas Hitiris; Rajiv Mohanraj; John Norrie; Graeme J Sills; Martin J Brodie
Predictors of pharmacoresistant epilepsy.
Epilepsy research 2007;75(2-3):192-6.
2007: Linda J Stephen; Graeme J Sills; John Paul Leach; Elaine Butler; Pamela Parker; Nikolas Hitiris; Veronica M Leach; Elaine A Wilson; Martin J Brodie
Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy.
Epilepsy research 2007;75(2-3):122-9.
2007: Graeme J Sills; Martin Brodie
Pharmacokinetics and drug interactions with zonisamide.
Epilepsia 2007;48(3):435-41.
2007: Nikolas Hitiris; Suraya Suratman; Kevin Kelly; Linda J Stephen; Graeme J Sills; Martin J Brodie
Sudden unexpected death in epilepsy: a search for risk factors.
Epilepsy & behavior : E&B 2007;10(1):138-41.
2005: Graeme J Sills; Rajiv Mohanraj; Elaine Butler; Sheila McCrindle; Lindsay Collier; Elaine A Wilson; Martin J Brodie
Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.
Epilepsia 2005;46(5):643-7.
2004: Graeme J Sills; Elaine Butler; George G Thompson; Martin J Brodie
Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models.
Seizure : the journal of the British Epilepsy Association 2004;13(5):287-95.
2003: J McDonagh; Linda J Stephen; Fiona M Dolan; Stuart Parks; Gordon N Dutton; K Kelly; David Keating; Graeme J Sills; Martin J Brodie
Peripheral retinal dysfunction in patients taking vigabatrin.
Neurology 2003;61(12):1690-4.
2003: Graeme J Sills; Elaine Butler; Gerard Forrest; Neville Ratnaraj; Philip N Patsalos; Martin J Brodie
Vigabatrin, but not gabapentin or topiramate, produces concentration-related effects on enzymes and intermediates of the GABA shunt in rat brain and retina.
Epilepsia 2003;44(7):886-92.
2003: Patrick Kwan; Graeme J Sills; Elaine Butler; Timothy W Gant; Martin J Brodie
Differential expression of multidrug resistance genes in naïve rat brain.
Neuroscience letters 2003;339(1):33-6.
2003: Graeme J Sills
Pre-clinical studies with the GABAergic compounds vigabatrin and tiagabine.
Epileptic disorders : international epilepsy journal with videotape 2003;5(1):51-6.
2002: Patrick Kwan; Graeme J Sills; Elaine Butler; Timothy W Gant; Brian S Meldrum; Martin J Brodie
Regional expression of multidrug resistance genes in genetically epilepsy-prone rat brain after a single audiogenic seizure.
Epilepsia 2002;43(11):1318-23.
2002: Graeme J Sills; Sarah Lynagh; Gerard Forrest; Martin J Brodie
Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride.
Epilepsy research 2002;49(3):247-54.
2002: Kevin Kelly; Linda J Stephen; Graeme J Sills; Martin J Brodie
Topiramate in patients with learning disability and refractory epilepsy.
Epilepsia 2002;43(4):399-402.
2002: Sarah Lynagh; Graeme J Sills; Trevor W Stone; Martin J Brodie
Differential effects of remacemide and desglycinyl-remacemide on epileptiform burst firing in the rat hippocampal slice.
Neuroscience letters 2002;321(1-2):33-6.
2002: Sarah Lynagh; Graeme J Sills; George G Thompson; Martin J Brodie
Na(+) channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes.
European journal of pharmacology 2002;438(1-2):63-8.
2001: Graeme J Sills; Martin J Brodie
Update on the mechanisms of action of antiepileptic drugs.
Epileptic disorders : international epilepsy journal with videotape 2001;3(4):165-72.
2001: Graeme J Sills; Philip N Patsalos; Elaine Butler; Gerard Forrest; Neville Ratnaraj; Martin J Brodie
Visual field constriction: accumulation of vigabatrin but not tiagabine in the retina.
Neurology 2001;57(2):196-200.
2001: Patrick Kwan; Graeme J Sills; Martin J Brodie
The mechanisms of action of commonly used antiepileptic drugs.
Pharmacology & therapeutics 2001;90(1):21-34.
2000: Patrick Kwan; Graeme J Sills; K Kelly; Elaine Butler; Martin J Brodie
Glutamic acid decarboxylase autoantibodies in controlled and uncontrolled epilepsy: a pilot study.
Epilepsy research 2000;42(2-3):191-5.
2000: Graeme J Sills; C Rundfeldt; Elaine Butler; Gerard Forrest; George G Thompson; Martin J Brodie
A neurochemical study of the novel antiepileptic drug retigabine in mouse brain.
Pharmacological research : the official journal of the Italian Pharmacological Society 2000;42(6):553-7.
2000: Sarah Lynagh; C McNeill; Graeme J Sills; Martin J Brodie
Simultaneous determination of remacemide hydrochloride and desglycinylremacemide (AR-R12495XX) in brain tissue by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 2000;746(2):325-9.
2000: Linda J Stephen; Graeme J Sills; Martin J Brodie
Topiramate in refractory epilepsy: a prospective observational study.
Epilepsia 2000;41(8):977-80.
2000: Graeme J Sills; John Paul Leach; W S Kilpatrick; CM Fraser; George G Thompson; Martin J Brodie
Concentration-effect studies with topiramate on selected enzymes and intermediates of the GABA shunt.
Epilepsia 2000;41 Suppl 1():S30-4.
1999: Graeme J Sills; Elaine Butler; George G Thompson; Martin J Brodie
Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study.
Seizure : the journal of the British Epilepsy Association 1999;8(7):404-11.
1999: CM Fraser; Graeme J Sills; Elaine Butler; George G Thompson; K Lindsay; R Duncan; A Howatson; Martin J Brodie
Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from foetal and adult brain tissue.
Epileptic disorders : international epilepsy journal with videotape 1999;1(3):153-7.
1999: Linda J Stephen; A R McLellan; J H Harrison; D Shapiro; Marek Dominiczak; Graeme J Sills; Martin J Brodie
Bone density and antiepileptic drugs: a case-controlled study.
Seizure : the journal of the British Epilepsy Association 1999;8(6):339-42.
1999: CM Fraser; Graeme J Sills; Gerard Forrest; George G Thompson; Martin J Brodie
Neurochemical studies with the anticonvulsant felbamate in mouse brain.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(3):257-61.
1999: CM Fraser; Graeme J Sills; Gerard Forrest; George G Thompson; Martin J Brodie
Effects of anti-epileptic drugs on glutamine synthetase activity in mouse brain.
British journal of pharmacology 1999;126(7):1634-8.
1998: C L Read; Linda J Stephen; I H Stolarek; A Paul; Graeme J Sills; Martin J Brodie
Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study.
Seizure : the journal of the British Epilepsy Association 1998;7(2):159-62.
1998: Linda J Stephen; Graeme J Sills; Martin J Brodie
Lamotrigine and topiramate may be a useful combination.
Lancet 1998;351(9107):958-9.
1998: Elaine A Wilson; Graeme J Sills; Gerard Forrest; Martin J Brodie
High dose gabapentin in refractory partial epilepsy: clinical observations in 50 patients.
Epilepsy research 1998;29(2):161-6.
1997: John Paul Leach; Graeme J Sills; Elaine Butler; Gerard Forrest; George G Thompson; Martin J Brodie
Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain.
British journal of pharmacology 1997;121(5):923-6.
1997: John Paul Leach; Graeme J Sills; Elaine Butler; Gerard Forrest; George G Thompson; Martin J Brodie
Neurochemical actions of gabapentin in mouse brain.
Epilepsy research 1997;27(3):175-80.
1997: John Paul Leach; Graeme J Sills; Elaine Butler; Gerard Forrest; George G Thompson; Martin J Brodie
Neurochemical actions of vigabatrin and tiagabine alone and in combination in mouse cortex.
General pharmacology 1997;28(5):715-9.
1997: Graeme J Sills; John Paul Leach; CM Fraser; Gerard Forrest; Philip N Patsalos; Martin J Brodie
Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain.
European journal of pharmacology 1997;325(1):35-40.
1996: John Paul Leach; Graeme J Sills; A Majid; Elaine Butler; A Carswell; George G Thompson; M J Brodie
Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes.
Seizure : the journal of the British Epilepsy Association 1996;5(3):229-34.
1996: Gerard Forrest; Graeme J Sills; John Paul Leach; M J Brodie
Determination of gabapentin in plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1996;681(2):421-5.
1994: Graeme J Sills; A Carswell; M J Brodie
Dose-response relationships with nimodipine against electroshock seizures in mice.
Epilepsia 1994;35(2):437-42.
1992: J H Connick; G C Heywood; Graeme J Sills; George G Thompson; M J Brodie; Trevor W Stone
Nicotinylalanine increases cerebral kynurenic acid content and has anticonvulsant activity.
General pharmacology 1992;23(2):235-9.