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Israel Silman
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83
Sussman, Joel
30
Harel, Michal
13
Greenblatt, Harry
13
Toker, Lilly
12
Weik, Martin
12
Weiner, Lev
10
Kryger, G
10
Brumshtein, Boris
9
Dvir, Hay
8
Futerman, Anthony
7
Ravelli, Raimond
7
Raves, Maria
6
Shin, Irina
6
Millard, Charles
6
Zeev-Ben-Mordehai, Tzviya
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All Publications
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2009: Zeev-Ben-Mordehai Tzviya; Mylonas Efstratios; Paz Aviv; Peleg Yoav; Toker Lilly; Silman Israel; Svergun Dmitri I; Sussman Joel L
The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.
Biophysical journal 2009;97(8):2316-26.
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2009: Khersonsky Olga; Rosenblat Mira; Toker Lilly; Yacobson Shiri; Hugenmatter Adrian; Silman Israel; Sussman Joel L; Aviram Michael; Tawfik Dan S
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
Biochemistry 2009;48(28):6644-54.
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2009: Brumshtein Boris; Aguilar-Moncayo Matilde; García-Moreno M Isabel; Ortiz Mellet Carmen; García Fernández José M; Silman Israel; Shaaltiel Yoseph; Aviezer David; Sussman Joel L; Futerman Anthony H
6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.
Chembiochem : a European journal of chemical biology 2009;10(9):1480-5.
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2009: Paz Aviv; Xie Qiong; Greenblatt Harry M; Fu Wei; Tang Yun; Silman Israel; Qiu Zhuibai; Sussman Joel L
The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.
Journal of medicinal chemistry 2009;52(8):2543-9.
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2009: Gabel F; Masson P; Froment M-T; Doctor B P; Saxena A; Silman I; Zaccai G; Weik M
Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate.
Biophysical journal 2009;96(4):1489-94.
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2009: Zeev-Ben-Mordehai Tzviya; Paz Aviv; Peleg Yoav; Toker Lilly; Wolf Sharon G; Rydberg Edwin H; Sussman Joel L; Silman Israel
Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization.
Protein expression and purification 2009;63(2):147-57.
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2008: Kacher Yaacov; Brumshtein Boris; Boldin-Adamsky Swetlana; Toker Lilly; Shainskaya Alla; Silman Israel; Sussman Joel L; Futerman Anthony H
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.
Biological chemistry 2008;389(11):1361-9.
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2008: Silman Israel; Sussman Joel L
Acetylcholinesterase: how is structure related to function?
Chemico-biological interactions 2008;175(1-3):3-10.
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2008: Xu Yechun; Colletier Jacques-Philippe; Weik Martin; Jiang Hualiang; Moult John; Silman Israel; Sussman Joel L
Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.
Biophysical journal 2008;95(5):2500-11.
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2008: Colletier Jacques-Philippe; Bourgeois Dominique; Sanson Benoît; Fournier Didier; Sussman Joel L; Silman Israel; Weik Martin
Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11742-7.
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2008: Paz Aviv; Zeev-Ben-Mordehai Tzviya; Lundqvist Martin; Sherman Eilon; Mylonas Efstratios; Weiner Lev; Haran Gilad; Svergun Dmitri I; Mulder Frans A A; Sussman Joel L; Silman Israel
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3.
Biophysical journal 2008;95(4):1928-44.
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2008: Harel Michal; Sonoda Leilani K; Silman Israel; Sussman Joel L; Rosenberry Terrone L
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.
Journal of the American Chemical Society 2008;130(25):7856-61.
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2008: Xu Yechun; Colletier Jacques Ph; Jiang Hualiang; Silman Israel; Sussman Joel L; Weik Martin
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.
Protein science : a publication of the Protein Society 2008;17(4):601-5.
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2008: Tsvetkov Peter; Asher Gad; Paz Aviv; Reuven Nina; Sussman Joel L; Silman Israel; Shaul Yosef
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
Proteins 2008;70(4):1357-66.
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2008: Hodis Eran; Prilusky Jaime; Martz Eric; Silman Israel; Moult John; Sussman Joel L
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Genome biology 2008;9(8):R121.
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2007: Colletier Jacques-Philippe; Royant Antoine; Specht Alexandre; Sanson Benoît; Nachon Florian; Masson Patrick; Zaccai Giuseppe; Sussman Joel L; Goeldner Maurice; Silman Israel; Bourgeois Dominique; Weik Martin
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1115-28.
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2007: Harel Michal; Brumshtein Boris; Meged Ran; Dvir Hay; Ravelli Raimond B G; McCarthy Andrew; Toker Lilly; Silman Israel; Sussman Joel L
3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability.
Arhiv za higijenu rada i toksikologiju 2007;58(3):347-53.
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2007: Brumshtein Boris; Greenblatt Harry M; Butters Terry D; Shaaltiel Yoseph; Aviezer David; Silman Israel; Futerman Anthony H; Sussman Joel L
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
The Journal of biological chemistry 2007;282(39):29052-8.
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2007: Shaaltiel Yoseph; Bartfeld Daniel; Hashmueli Sharon; Baum Gideon; Brill-Almon Einat; Galili Gad; Dym Orly; Boldin-Adamsky Swetlana A; Silman Israel; Sussman Joel L; Futerman Anthony H; Aviezer David
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
Plant biotechnology journal 2007;5(5):579-90.
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2007: Felder Clifford E; Prilusky Jaime; Silman Israel; Sussman Joel L
A server and database for dipole moments of proteins.
Nucleic acids research 2007;35(Web Server issue):W512-21.
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2007: Haviv H; Wong D M; Silman I; Sussman J L
Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Current topics in medicinal chemistry 2007;7(4):375-87.
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2006: Brumshtein Boris; Wormald Mark R; Silman Israel; Futerman Anthony H; Sussman Joel L
Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1458-65.
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2006: Esnouf Robert M; Hamer R; Sussman J L; Silman I; Trudgian D; Yang Z-R; Prilusky Jaime
Honing the in silico toolkit for detecting protein disorder.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1260-6.
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2006: Rydberg Edwin H; Brumshtein Boris; Greenblatt Harry M; Wong Dawn M; Shaya David; Williams Larry D; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal of medicinal chemistry 2006;49(18):5491-500.
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2006: Colletier Jacques-Philippe; Fournier Didier; Greenblatt Harry M; Stojan Jure; Sussman Joel L; Zaccai Giuseppe; Silman Israel; Weik Martin
Structural insights into substrate traffic and inhibition in acetylcholinesterase.
The EMBO journal 2006;25(12):2746-56.
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2005: Harel Michal; Hyatt Janice L; Brumshtein Boris; Morton Christopher L; Wadkins Randy M; Silman Israel; Sussman Joel L; Potter Philip M
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.
Chemico-biological interactions 2005;157-158():153-7.
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2005: Hyatt Janice L; Tsurkan Lyudmila; Morton Christopher L; Yoon Kyoung J P; Harel Michal; Brumshtein Boris; Silman Israel; Sussman Joel L; Wadkins Randy M; Potter Philip M
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.
Chemico-biological interactions 2005;157-158():247-52.
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2005: Gabel F; Weik M; Masson P; Renault F; Fournier D; Brochier L; Doctor B P; Saxena A; Silman I; Zaccai G
Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study.
Biophysical journal 2005;89(5):3303-11.
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2005: Albeck Shira; Burstein Yigal; Dym Orly; Jacobovitch Yossi; Levi Nurit; Meged Ran; Michael Yigal; Peleg Yoav; Prilusky Jaime; Schreiber Gideon; Silman Israel; Unger Tamar; Sussman Joel L
Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1364-72.
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2005: Haviv Haim; Wong Dawn M; Greenblatt Harry M; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.
Journal of the American Chemical Society 2005;127(31):11029-36.
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2005: Prilusky Jaime; Felder Clifford E; Zeev-Ben-Mordehai Tzviya; Rydberg Edwin H; Man Orna; Beckmann Jacques S; Silman Israel; Sussman Joel L
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.
Bioinformatics (Oxford, England) 2005;21(16):3435-8.
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2005: Silman Israel; Sussman Joel L
Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology.
Current opinion in pharmacology 2005;5(3):293-302.
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2005: Premkumar Lakshmanane; Sawkar Anu R; Boldin-Adamsky Swetlana; Toker Lilly; Silman Israel; Kelly Jeffery W; Futerman Anthony H; Sussman Joel L
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.
The Journal of biological chemistry 2005;280(25):23815-9.
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2005: Harel Michal; Hyatt Janice L; Brumshtein Boris; Morton Christopher L; Yoon Kyoung Jin P; Wadkins Randy M; Silman Israel; Sussman Joel L; Potter Philip M
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Molecular pharmacology 2005;67(6):1874-81.
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2005: Hasin Yehudit; Avidan Nili; Bercovich Dani; Korczyn Amos D; Silman Israel; Beckmann Jacques S; Sussman Joel L
Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations.
Current Alzheimer research 2005;2(2):207-18.
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2004: Greenblatt Harry M; Guillou Catherine; Guénard Daniel; Argaman Anat; Botti Simone; Badet Bernard; Thal Claude; Silman Israel; Sussman Joel L
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
Journal of the American Chemical Society 2004;126(47):15405-11.
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2004: Dvir Hay; Harel Michal; Bon Suzanne; Liu Wang-Qing; Vidal Michel; Garbay Christiane; Sussman Joel L; Massoulié Jean; Silman Israel
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.
The EMBO journal 2004;23(22):4394-405.
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2004: Hasin Yehudit; Avidan Nili; Bercovich Dani; Korczyn Amos; Silman Israel; Beckmann Jacques S; Sussman Joel L
A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene.
Human mutation 2004;24(5):408-16.
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2004: Gabel F; Weik M; Doctor B P; Saxena A; Fournier D; Brochier L; Renault F; Masson P; Silman I; Zaccai G
The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study.
Biophysical journal 2004;86(5):3152-65.
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2004: Harel Michal; Aharoni Amir; Gaidukov Leonid; Brumshtein Boris; Khersonsky Olga; Meged Ran; Dvir Hay; Ravelli Raimond B G; McCarthy Andrew; Toker Lilly; Silman Israel; Sussman Joel L; Tawfik Dan S
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.
Nature structural & molecular biology 2004;11(5):412-9.
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2004: Futerman Anthony H; Sussman Joel L; Horowitz Mia; Silman Israel; Zimran Ari
New directions in the treatment of Gaucher disease.
Trends in pharmacological sciences 2004;25(3):147-51.
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2004: Pe'er Itsik; Felder Clifford E; Man Orna; Silman Israel; Sussman Joel L; Beckmann Jacques S
Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla.
Proteins 2004;54(1):20-40.
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2004: Aharoni Amir; Gaidukov Leonid; Yagur Shai; Toker Lilly; Silman Israel; Tawfik Dan S
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):482-7.
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2003: Zeev-Ben-Mordehai Tzviya; Rydberg Edwin H; Solomon Ariel; Toker Lilly; Auld Vanessa J; Silman Israel; Botti Simone; Sussman Joel L
The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.
Proteins 2003;53(3):758-67.
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2003: Millard Charles B; Shnyrov Valery L; Newstead Simon; Shin Irina; Roth Esther; Silman Israel; Weiner Lev
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.
Protein science : a publication of the Protein Society 2003;12(10):2337-47.
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2003: Dvir Hay; Harel Michal; McCarthy Andrew A; Toker Lilly; Silman Israel; Futerman Anthony H; Sussman Joel L
X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease.
EMBO reports 2003;4(7):704-9.
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2003: Zeev-Ben-Mordehai T; Silman I; Sussman J L
Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure.
Biopolymers 2003;68(3):395-406.
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2003: Wong Dawn M; Greenblatt Harry M; Dvir Hay; Carlier Paul R; Han Yi-Fan; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Journal of the American Chemical Society 2003;125(2):363-73.
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2003: Greenblatt Harry M; Dvir Hay; Silman Israel; Sussman Joel L
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.
Journal of molecular neuroscience : MN 2003;20(3):369-83.
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2002: Weik Martin; Bergès Jacqueline; Raves Maria L; Gros Piet; McSweeney Sean; Silman Israel; Sussman Joel L; Houée-Levin Chantal; Ravelli Raimond B G
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation.
Journal of synchrotron radiation 2002;9(Pt 6):342-6.
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2002: Felder Clifford E; Harel Michal; Silman Israel; Sussman Joel L
Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1765-71.
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2002: Dvir H; Jiang H L; Wong D M; Harel M; Chetrit M; He X C; Jin G Y; Yu G L; Tang X C; Silman I; Bai D L; Sussman J L
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
Biochemistry 2002;41(35):10810-8.
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2002: Shin I; Wachtel E; Roth E; Bon C; Silman I; Weiner L
Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?
Protein science : a publication of the Protein Society 2002;11(8):2022-32.
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2002: Koellner Gertraud; Steiner Thomas; Millard Charles B; Silman Israel; Sussman Joel L
A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica.
Journal of molecular biology 2002;320(4):721-5.
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2002: Bar-On P; Millard C B; Harel M; Dvir H; Enz A; Sussman J L; Silman I
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.
Biochemistry 2002;41(11):3555-64.
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2002: Dvir H; Wong D M; Harel M; Barril X; Orozco M; Luque F J; Muñoz-Torrero D; Camps P; Rosenberry T L; Silman I; Sussman J L
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Biochemistry 2002;41(9):2970-81.
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2001: Weik M; Ravelli R B; Silman I; Sussman J L; Gros P; Kroon J
Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes.
Protein science : a publication of the Protein Society 2001;10(10):1953-61.
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2001: Doucet-Personeni C; Bentley P D; Fletcher R J; Kinkaid A; Kryger G; Pirard B; Taylor A; Taylor R; Taylor J; Viner R; Silman I; Sussman J L; Greenblatt H M; Lewis T
A structure-based design approach to the development of novel, reversible AChE inhibitors.
Journal of medicinal chemistry 2001;44(20):3203-15.
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2001: Nicolas A; Ferron F; Toker L; Sussman J L; Silman I
Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1348-50.
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2001: Weik M; Kryger G; Schreurs A M; Bouma B; Silman I; Sussman J L; Gros P; Kroon J
Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):566-73.
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2000: Kryger G; Harel M; Giles K; Toker L; Velan B; Lazar A; Kronman C; Barak D; Ariel N; Shafferman A; Silman I; Sussman J L
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
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2000: Harel M; Kryger G; Rosenberry T L; Mallender W D; Lewis T; Fletcher R J; Guss J M; Silman I; Sussman J L
Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors.
Protein science : a publication of the Protein Society 2000;9(6):1063-72.
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2000: Koellner G; Kryger G; Millard C B; Silman I; Sussman J L; Steiner T
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Journal of molecular biology 2000;296(2):713-35.
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2000: Weik M; Ravelli R B; Kryger G; McSweeney S; Raves M L; Harel M; Gros P; Silman I; Kroon J; Sussman J L
Specific chemical and structural damage to proteins produced by synchrotron radiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):623-8.
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1999: Arnon R; Silman I; Tarrab-Hazdai R
Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday.
Protein science : a publication of the Protein Society 1999;8(12):2553-61.
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1999: Greenblatt H M; Kryger G; Lewis T; Silman I; Sussman J L
Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution.
FEBS letters 1999;463(3):321-6.
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1999: Tarrab-Hazdai R; Toker L; Silman I; Arnon R
Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin.
The Biochemical journal 1999;344 Pt 3():945-51.
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1999: Weiner L; Roth E; Mazur Y; Silman I
Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin.
Biochemistry 1999;38(35):11401-5.
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1999: Millard C B; Kryger G; Ordentlich A; Greenblatt H M; Harel M; Raves M L; Segall Y; Barak D; Shafferman A; Silman I; Sussman J L
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry 1999;38(22):7032-9.
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1999: Morel N; Bon S; Greenblatt H M; Van Belle D; Wodak S J; Sussman J L; Massoulié J; Silman I
Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase.
Molecular pharmacology 1999;55(6):982-92.
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1999: Silman I; Millard C B; Ordentlich A; Greenblatt H M; Harel M; Barak D; Shafferman A; Sussman J L
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.
Chemico-biological interactions 1999;119-120():43-52.
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1999: Kryger G; Silman I; Sussman J L
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Structure (London, England : 1993) 1999;7(3):297-307.
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1998: Ravelli R B; Raves M L; Ren Z; Bourgeois D; Roth M; Kroon J; Silman I; Sussman J L
Static Laue diffraction studies on acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1359-66.
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1998: Kryger G; Silman I; Sussman J L
Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica.
Journal of physiology, Paris 1998;92(3-4):191-4.
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1998: Botti S A; Felder C E; Sussman J L; Silman I
Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs.
Protein engineering 1998;11(6):415-20.
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1998: Shin I; Silman I; Bon C; Weiner L
Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus.
Biochemistry 1998;37(13):4310-6.
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1997: Felder C E; Botti S A; Lifson S; Silman I; Sussman J L
External and internal electrostatic potentials of cholinesterase models.
Journal of molecular graphics & modelling 1997;15(5):318-27, 335-7.
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1997: Shin I; Kreimer D; Silman I; Weiner L
Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2848-52.
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1997: Raves M L; Harel M; Pang Y P; Silman I; Kozikowski A P; Sussman J L
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nature structural biology 1997;4(1):57-63.
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1996: Kreimer D I; Shin I; Shnyrov V L; Villar E; Silman I; Weiner L
Two partially unfolded states of Torpedo californica acetylcholinesterase.
Protein science : a publication of the Protein Society 1996;5(9):1852-64.
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1996: Faerman C; Ripoll D; Bon S; Le Feuvre Y; Morel N; Massoulié J; Sussman J L; Silman I
Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function.
FEBS letters 1996;386(1):65-71.
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1996: Shin I; Silman I; Weiner L M
Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes.
Protein science : a publication of the Protein Society 1996;5(1):42-51.
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1995: Harel M; Kleywegt G J; Ravelli R B; Silman I; Sussman J L
Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.
Structure (London, England : 1993) 1995;3(12):1355-66.
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1995: Kreimer D I; Shnyrov V L; Villar E; Silman I; Weiner L
Irreversible thermal denaturation of Torpedo californica acetylcholinesterase.
Protein science : a publication of the Protein Society 1995;4(11):2349-57.
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1995: Eichler J; Silman I
The activity of an endoplasmic reticulum-localized pool of acetylcholinesterase is modulated by heat shock.
The Journal of biological chemistry 1995;270(9):4466-72.
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1995: Eichler J; Tolliday N; Toker L; Silman I
Purification and characterization of HSP70 proteins from Torpedo electric organ.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1995;110(2):409-15.
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1994: Kreimer D I; Szosenfogel R; Goldfarb D; Silman I; Weiner L
Two-state transition between molten globule and unfolded states of acetylcholinesterase as monitored by electron paramagnetic resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12145-9.
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1994: Eichler J; Kreimer D I; Varon L; Silman I; Weiner L
A "molten globule" of Torpedo acetylcholinesterase undergoes thiol-disulfide exchange.
The Journal of biological chemistry 1994;269(48):30093-6.
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1994: Kreimer D I; Dolginova E A; Raves M; Sussman J L; Silman I; Weiner L
A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials.
Biochemistry 1994;33(48):14407-18.
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1994: Silman I; Harel M; Axelsen P; Raves M; Sussman J L
Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents.
Biochemical Society transactions 1994;22(3):745-9.
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1994: Gilson M K; Straatsma T P; McCammon J A; Ripoll D R; Faerman C H; Axelsen P H; Silman I; Sussman J L
Open "back door" in a molecular dynamics simulation of acetylcholinesterase.
Science (New York, N.Y.) 1994;263(5151):1276-8.
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1994: Weiner L; Kreimer D; Roth E; Silman I
Oxidative stress transforms acetylcholinesterase to a molten-globule-like state.
Biochemical and biophysical research communications 1994;198(3):915-22.
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1994: Mehlert A; Varon L; Silman I; Homans S W; Ferguson M A
Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):243-8.
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1994: Axelsen P H; Harel M; Silman I; Sussman J L
Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.
Protein science : a publication of the Protein Society 1994;3(2):188-97.
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1993: Mehlert A; Varon L; Silman I; Homans S W; Ferguson M A
Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica.
The Biochemical journal 1993;296 ( Pt 2)():473-9.
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1993: Harel M; Schalk I; Ehret-Sabatier L; Bouet F; Goeldner M; Hirth C; Axelsen P H; Silman I; Sussman J L
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9031-5.
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1993: Ripoll D R; Faerman C H; Axelsen P H; Silman I; Sussman J L
An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5128-32.
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1993: Sussman J L; Harel M; Silman I
Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs.
Chemico-biological interactions 1993;87(1-3):187-97.
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1993: Cygler M; Schrag J D; Sussman J L; Harel M; Silman I; Gentry M K; Doctor B P
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.
Protein science : a publication of the Protein Society 1993;2(3):366-82.
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1993: Mehlert A; Silman I; Homans S W; Ferguson M A
The structure of the glycosylphosphatidylinositol anchor from Torpedo californica acetylcholinesterase.
Biochemical Society transactions 1993;21(1):43S.
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1992: Dolginova E A; Roth E; Silman I; Weiner L M
Chemical modification of Torpedo acetylcholinesterase by disulfides: appearance of a "molten globule" state.
Biochemistry 1992;31(48):12248-54.
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1992: Harel M; Sussman J L; Krejci E; Bon S; Chanal P; Massoulié J; Silman I
Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10827-31.
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1992: Ollis D L; Cheah E; Cygler M; Dijkstra B; Frolow F; Franken S M; Harel M; Remington S J; Silman I; Schrag J
The alpha/beta hydrolase fold.
Protein engineering 1992;5(3):197-211.
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1991: Eichler J; Toker L; Silman I
Effect of heat shock on acetylcholinesterase activity in chick muscle cultures.
FEBS letters 1991;293(1-2):16-20.
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1991: Harel M; Su C T; Frolow F; Ashani Y; Silman I; Sussman J L
Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
Journal of molecular biology 1991;221(3):909-18.
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1991: Sussman J L; Harel M; Frolow F; Oefner C; Goldman A; Toker L; Silman I
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.
Science (New York, N.Y.) 1991;253(5022):872-9.
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1991: Harel M; Su C T; Frolow F; Silman I; Sussman J L
Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products.
Biochemistry 1991;30(21):5217-25.
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1991: Espinoza B; Silman I; Arnon R; Tarrab-Hazdai R
Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni.
European journal of biochemistry / FEBS 1991;195(3):863-70.
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1990: Steinberg N; Roth E; Silman I
Torpedo acetylcholinesterase is inactivated by thiol reagents.
Biochemistry international 1990;21(6):1043-50.
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1989: Grunwald J; Segall Y; Shirin E; Waysbort D; Steinberg N; Silman I; Ashani Y
Aged and non-aged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin. Preparation and comparison by 31P-NMR spectroscopy.
Biochemical pharmacology 1989;38(19):3157-68.
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1989: Steinberg N; van der Drift A C; Grunwald J; Segall Y; Shirin E; Haas E; Ashani Y; Silman I
Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy.
Biochemistry 1989;28(3):1248-53.
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1989: Steinberg N; Grunwald J; Roth E; August R; Haas E; Ashani Y; Silman I
Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin.
Progress in clinical and biological research 1989;289():293-304.
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1988: Sussman J L; Harel M; Frolow F; Varon L; Toker L; Futerman A H; Silman I
Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C.
Journal of molecular biology 1988;203(3):821-3.
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1988: Espinoza B; Tarrab-Hazdai R; Silman I; Arnon R
Acetylcholinesterase in Schistosoma mansoni is anchored to the membrane via covalently attached phosphatidylinositol.
Molecular and biochemical parasitology 1988;29(2-3):171-9.
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1987: Silman I; Futerman A H
Modes of attachment of acetylcholinesterase to the surface membrane.
European journal of biochemistry / FEBS 1987;170(1-2):11-22.
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1987: Doctor B P; Toker L; Roth E; Silman I
Microtiter assay for acetylcholinesterase.
Analytical biochemistry 1987;166(2):399-403.
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