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Israel Silman

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Moshe Ben-David; Mikael Elias; Israel Silman; Joel L Sussman; Grzegorz Wieczorek; Dan S Tawfik
Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme.
Israel Silman; Joel L Sussman; Mathilde M Triquigneaux; Yacov Ashani; Leesa J Deterding; Marilyn Ehrenshaft; Ronald P Mason; Aviv Paz; Esther Roth; Valery L Shnyrov; Yechun Xu; Lev Weiner
The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.
Aviv Paz; Esther Roth; Valery L Shnyrov; Israel Silman; Joel L Sussman; Yacov Ashani; Yechun Xu; Lev Weiner
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.

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All Publications

2013: Moshe Ben-David; Mikael Elias; Israel Silman; Joel L Sussman; Grzegorz Wieczorek; Dan S Tawfik
Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme.
Journal of molecular biology 2013;425(6):1028-38.
2013: Israel Silman; Joel L Sussman; Mathilde M Triquigneaux; Yacov Ashani; Leesa J Deterding; Marilyn Ehrenshaft; Ronald P Mason; Aviv Paz; Esther Roth; Valery L Shnyrov; Yechun Xu; Lev Weiner
The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy.
Chemico-biological interactions 2013;203(1):63-6.
2012: Aviv Paz; Esther Roth; Valery L Shnyrov; Israel Silman; Joel L Sussman; Yacov Ashani; Yechun Xu; Lev Weiner
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.
Protein science : a publication of the Protein Society 2012;21(8):1138-52.
2012: Moshe Ben-David; Elisabet Duñach; Mikael Elias; Jean-Jacques Filippi; Israel Silman; Joel L Sussman; Dan S Tawfik
Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1.
Journal of molecular biology 2012;418(3-4):181-96.
2012: Moshe Goldsmith; Haim Leader; Israel Silman; Yair Simo; Joel L Sussman; Yacov Ashani; Moshe Ben-David; Dan S Tawfik
Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification.
Chemistry & biology 2012;19(4):456-66.
2012: Sagar D Khare; Yakov Kipnis; Haim Leader; Israel Silman; Yifan Song; Barry L Stoddard; Joel L Sussman; Ryo Takeuchi; Dan S Tawfik; Yacov Ashani; Jasmine L Gallaher; Moshe Goldsmith; Per Greisen; David Baker
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nature chemical biology 2012;8(3):294-300.
2011: Yacov Ashani; Moshe Goldsmith; Haim Leader; Israel Silman; Joel L Sussman; Dan S Tawfik
In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases.
Toxicology letters 2011;206(1):24-8.
2011: Marcin J Suskiewicz; Joel L Sussman; Israel Silman; Yosef Shaul
Context-dependent resistance to proteolysis of intrinsically disordered proteins.
Protein science : a publication of the Protein Society 2011;20(8):1285-97.
2011: Benoît Sanson; Israel Silman; Joel L Sussman; Jacques-Philippe Colletier; Hualiang Jiang; P Therese Lang; Yechun Xu; Martin Weik
Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations.
Protein science : a publication of the Protein Society 2011;20(7):1114-8.
2011: Boris Brumshtein; Matilde Aguilar-Moncayo; Juan M Benito; José M García Fernandez; Israel Silman; Yoseph Shaaltiel; David Aviezer; Joel L Sussman; Anthony H Futerman; Carmen Ortiz Mellet
Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.
Organic & biomolecular chemistry 2011;9(11):4160-7.
2011: Lev Weiner; Esther Roth; Israel Silman
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen.
Photochemistry and photobiology 2011;87(2):308-16.
2011: Rinkoo Gupta; Moshe Goldsmith; Yacov Ashani; Yair Simo; Gavriel Mullokandov; Hagit Bar; Moshe Ben-David; Haim Leader; Raanan Margalit; Israel Silman; Joel L Sussman; Dan S Tawfik
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
Nature chemical biology 2011;7(2):120-5.
2010: Marc N Offman; Marcin Krol; Israel Silman; Joel L Sussman; Anthony H Futerman
Molecular basis of reduced glucosylceramidase activity in the most common Gaucher disease mutant, N370S.
The Journal of biological chemistry 2010;285(53):42105-14.
2010: Yechun Xu; Jacques-Philippe Colletier; Martin Weik; Guangrong Qin; Hualiang Jiang; Israel Silman; Joel L Sussman
Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase.
Biophysical journal 2010;99(12):4003-11.
2010: Yacov Ashani; Rinkoo Gupta; M Goldsmith; Israel Silman; Joel Sussman; Dan S Tawfik; H Leader
Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.
Chemico-biological interactions 2010;187(1-3):362-9.
2010: Hay Dvir; Israel Silman; Michal Harel; Terrone L Rosenberry; Joel Sussman
Acetylcholinesterase: from 3D structure to function.
Chemico-biological interactions 2010;187(1-3):10-22.
2010: Boris Brumshtein; Paul Salinas; Brian Peterson; Victor Chan; Israel Silman; Joel Sussman; Philip J Savickas; Gregory S Robinson; Anthony H Futerman
Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages.
Glycobiology 2010;20(1):24-32.
2009: Benoît Sanson; Florian Nachon; Jacques-Philippe Colletier; Marie-Thérèse Froment; Lilly Toker; Harry M Greenblatt; Joel Sussman; Yaacov Ashani; Patrick Masson; Israel Silman; Martin Weik
Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime.
Journal of medicinal chemistry 2009;52(23):7593-603.
2009: Tzviya Zeev-Ben-Mordehai; Efstratios Mylonas; Aviv Paz; Yoav Peleg; Lilly Toker; Israel Silman; Dmitri I Svergun; Joel Sussman
The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.
Biophysical journal 2009;97(8):2316-26.
2009: Olga Khersonsky; Mira Rosenblat; Lilly Toker; Shiri Yacobson; Adrian Hugenmatter; Israel Silman; Joel Sussman; Michael Aviram; Dan S Tawfik
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
Biochemistry 2009;48(28):6644-54.
2009: Boris Brumshtein; Matilde Aguilar-Moncayo; M Isabel García-Moreno; Carmen Ortiz Mellet; José M García Fernández; Israel Silman; Yoseph Shaaltiel; David Aviezer; Joel Sussman; Anthony H Futerman
6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase.
Chembiochem : a European journal of chemical biology 2009;10(9):1480-5.
2009: Aviv Paz; Qiong Xie; Harry M Greenblatt; Wei Fu; Yun Tang; Israel Silman; Zhuibai Qiu; Joel Sussman
The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.
Journal of medicinal chemistry 2009;52(8):2543-9.
2009: Frank Gabel; Patrick Masson; M-T Froment; B P Doctor; A Saxena; Israel Silman; Giuseppe Zaccai; Martin Weik
Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its "aged" soman conjugate.
Biophysical journal 2009;96(4):1489-94.
2009: Tzviya Zeev-Ben-Mordehai; Aviv Paz; Yoav Peleg; Lilly Toker; Sharon Wolf; Edwin H Rydberg; Joel Sussman; Israel Silman
Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization.
Protein expression and purification 2009;63(2):147-57.
2008: Yaacov Kacher; Boris Brumshtein; Swetlana Boldin-Adamsky; Lilly Toker; Alla Shainskaya; Israel Silman; Joel Sussman; Anthony H Futerman
Acid beta-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.
Biological chemistry 2008;389(11):1361-9.
2008: Israel Silman; Joel Sussman
Acetylcholinesterase: how is structure related to function?
Chemico-biological interactions 2008;175(1-3):3-10.
2008: Yechun Xu; Jacques-Philippe Colletier; Martin Weik; Hualiang Jiang; John Moult; Israel Silman; Joel Sussman
Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.
Biophysical journal 2008;95(5):2500-11.
2008: Jacques-Philippe Colletier; Dominique Bourgeois; Benoît Sanson; Didier Fournier; Joel Sussman; Israel Silman; Martin Weik
Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11742-7.
2008: Aviv Paz; Tzviya Zeev-Ben-Mordehai; Martin Lundqvist; Eilon Sherman; Efstratios Mylonas; Lev Weiner; Gilad Haran; Dmitri I Svergun; Frans A A Mulder; Joel Sussman; Israel Silman
Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3.
Biophysical journal 2008;95(4):1928-44.
2008: Michal Harel; Leilani K Sonoda; Israel Silman; Joel Sussman; Terrone L Rosenberry
Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.
Journal of the American Chemical Society 2008;130(25):7856-61.
2008: Yechun Xu; Jacques Ph Colletier; Hualiang Jiang; Israel Silman; Joel Sussman; Martin Weik
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.
Protein science : a publication of the Protein Society 2008;17(4):601-5.
2008: Peter Tsvetkov; Gad Asher; Aviv Paz; Nina Reuven; Joel Sussman; Israel Silman; Yosef Shaul
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
Proteins 2008;70(4):1357-66.
2008: Eran Hodis; Jaime Prilusky; Eric Martz; Israel Silman; John Moult; Joel Sussman
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Genome biology 2008;9(8):R121.
2007: Jacques-Philippe Colletier; Antoine Royant; Alexandre Specht; Benoît Sanson; Florian Nachon; Patrick Masson; Giuseppe Zaccai; Joel Sussman; Maurice Goeldner; Israel Silman; Dominique Bourgeois; Martin Weik
Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 11):1115-28.
2007: Boris Brumshtein; Harry M Greenblatt; Terry D Butters; Yoseph Shaaltiel; David Aviezer; Israel Silman; Anthony H Futerman; Joel Sussman
Crystal structures of complexes of N-butyl- and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease.
The Journal of biological chemistry 2007;282(39):29052-8.
2007: Michal Harel; Boris Brumshtein; Ran Meged; Hay Dvir; Raimond B G Ravelli; Andrew McCarthy; Lilly Toker; Israel Silman; Joel Sussman
3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability.
Arhiv za higijenu rada i toksikologiju 2007;58(3):347-53.
2007: Yoseph Shaaltiel; Daniel Bartfeld; Sharon Hashmueli; Gideon Baum; Einat Brill-Almon; Gad Galili; Orly Dym; Swetlana Boldin-Adamsky; Israel Silman; Joel Sussman; Anthony H Futerman; David Aviezer
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
Plant biotechnology journal 2007;5(5):579-90.
2007: Clifford E Felder; Jaime Prilusky; Israel Silman; Joel Sussman
A server and database for dipole moments of proteins.
Nucleic acids research 2007;35(Web Server issue):W512-21.
2007: Haim Haviv; Dawn M Wong; Israel Silman; Joel Sussman
Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors.
Current topics in medicinal chemistry 2007;7(4):375-87.
2006: Boris Brumshtein; Mark R Wormald; Israel Silman; Anthony H Futerman; Joel Sussman
Structural comparison of differently glycosylated forms of acid-beta-glucosidase, the defective enzyme in Gaucher disease.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 12):1458-65.
2006: Robert M Esnouf; R Hamer; Joel Sussman; Israel Silman; D Trudgian; Z-R Yang; Jaime Prilusky
Honing the in silico toolkit for detecting protein disorder.
Acta crystallographica. Section D, Biological crystallography 2006;62(Pt 10):1260-6.
2006: Edwin H Rydberg; Boris Brumshtein; Harry M Greenblatt; Dawn M Wong; David Shaya; Larry D Williams; Paul R Carlier; Yuan-Ping Pang; Israel Silman; Joel Sussman
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal of medicinal chemistry 2006;49(18):5491-500.
2006: Jacques-Philippe Colletier; Didier Fournier; Harry M Greenblatt; Jure Stojan; Joel Sussman; Giuseppe Zaccai; Israel Silman; Martin Weik
Structural insights into substrate traffic and inhibition in acetylcholinesterase.
The EMBO journal 2006;25(12):2746-56.
2005: Michal Harel; Janice L Hyatt; Boris Brumshtein; Christopher L Morton; Randy M Wadkins; Israel Silman; Joel Sussman; Philip Potter
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.
Chemico-biological interactions 2005;157-158():153-7.
2005: Janice L Hyatt; Lyudmila Tsurkan; Christopher L Morton; Kyoung Jin P Yoon; Michal Harel; Boris Brumshtein; Israel Silman; Joel Sussman; Randy M Wadkins; Philip Potter
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.
Chemico-biological interactions 2005;157-158():247-52.
2005: Frank Gabel; Martin Weik; Patrick Masson; F Renault; Didier Fournier; L Brochier; B P Doctor; A Saxena; Israel Silman; Giuseppe Zaccai
Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study.
Biophysical journal 2005;89(5):3303-11.
2005: Shira Albeck; Yigal Burstein; Orly Dym; Yossi Jacobovitch; Nurit Levi; Ran Meged; Yigal Michael; Yoav Peleg; Jaime Prilusky; Gideon Schreiber; Israel Silman; Tamar Unger; Joel Sussman
Three-dimensional structure determination of proteins related to human health in their functional context at The Israel Structural Proteomics Center (ISPC). This paper was presented at ICCBM10.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 10):1364-72.
2005: Jaime Prilusky; Clifford E Felder; Tzviya Zeev-Ben-Mordehai; Edwin H Rydberg; Orna Man; Jacques Beckmann; Israel Silman; Joel Sussman
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded.
Bioinformatics (Oxford, England) 2005;21(16):3435-8.
2005: Haim Haviv; Dawn M Wong; Harry M Greenblatt; Paul R Carlier; Yuan-Ping Pang; Israel Silman; Joel Sussman
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.
Journal of the American Chemical Society 2005;127(31):11029-36.
2005: Premkumar Lakshmanane; Anu R Sawkar; Swetlana Boldin-Adamsky; Lilly Toker; Israel Silman; Jeffery W Kelly; Anthony H Futerman; Joel Sussman
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.
The Journal of biological chemistry 2005;280(25):23815-9.
2005: Israel Silman; Joel Sussman
Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology.
Current opinion in pharmacology 2005;5(3):293-302.
2005: Michal Harel; Janice L Hyatt; Boris Brumshtein; Christopher L Morton; Kyoung Jin P Yoon; Randy M Wadkins; Israel Silman; Joel Sussman; Philip Potter
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Molecular pharmacology 2005;67(6):1874-81.
2005: Yehudit Hasin; Nili Avidan; Dani Bercovich; Amos D Korczyn; Israel Silman; Jacques Beckmann; Joel Sussman
Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations.
Current Alzheimer research 2005;2(2):207-18.
2004: Harry M Greenblatt; Catherine Guillou; Daniel Guénard; Anat Argaman; Simone Botti; Bernard Badet; Claude Thal; Israel Silman; Joel Sussman
The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
Journal of the American Chemical Society 2004;126(47):15405-11.
2004: Hay Dvir; Michal Harel; Suzanne Bon; Wang-Qing Liu; Michel Vidal; Christiane Garbay; Joel Sussman; Jean Massoulié; Israel Silman
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.
The EMBO journal 2004;23(22):4394-405.
2004: Yehudit Hasin; Nili Avidan; Dani Bercovich; Amos D Korczyn; Israel Silman; Jacques Beckmann; Joel Sussman
A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene.
Human mutation 2004;24(5):408-16.
2004: Frank Gabel; Martin Weik; B P Doctor; A Saxena; Didier Fournier; L Brochier; F Renault; Patrick Masson; Israel Silman; Giuseppe Zaccai
The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study.
Biophysical journal 2004;86(5):3152-65.
2004: Michal Harel; Asaph Aharoni; Leonid Gaidukov; Boris Brumshtein; Olga Khersonsky; Ran Meged; Hay Dvir; Raimond B G Ravelli; Andrew McCarthy; Lilly Toker; Israel Silman; Joel Sussman; Dan S Tawfik
Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.
Nature structural & molecular biology 2004;11(5):412-9.
2004: Anthony H Futerman; Joel Sussman; Mia Horowitz; Israel Silman; Ari Zimran
New directions in the treatment of Gaucher disease.
Trends in pharmacological sciences 2004;25(3):147-51.
2004: Asaph Aharoni; Leonid Gaidukov; Shai Yagur; Lilly Toker; Israel Silman; Dan S Tawfik
Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(2):482-7.
2004: Itsik Pe'er; Clifford E Felder; Orna Man; Israel Silman; Joel Sussman; Jacques Beckmann
Proteomic signatures: amino acid and oligopeptide compositions differentiate among phyla.
Proteins 2004;54(1):20-40.
2003: Tzviya Zeev-Ben-Mordehai; Edwin H Rydberg; Ariel Solomon; Lilly Toker; Vanessa J Auld; Israel Silman; Simone Botti; Joel Sussman
The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.
Proteins 2003;53(3):758-67.
2003: Charles B Millard; Valery L Shnyrov; Simon Newstead; Irina Shin; Esther Roth; Israel Silman; Lev Weiner
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.
Protein science : a publication of the Protein Society 2003;12(10):2337-47.
2003: Hay Dvir; Michal Harel; Andrew A McCarthy; Lilly Toker; Israel Silman; Anthony H Futerman; Joel Sussman
X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease.
EMBO reports 2003;4(7):704-9.
2003: Tzviya Zeev-Ben-Mordehai; Israel Silman; Joel Sussman
Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure.
Biopolymers 2003;68(3):395-406.
2003: Dawn M Wong; Harry M Greenblatt; Hay Dvir; Paul R Carlier; Yi-Fan Han; Yuan-Ping Pang; Israel Silman; Joel Sussman
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Journal of the American Chemical Society 2003;125(2):363-73.
2003: Harry M Greenblatt; Hay Dvir; Israel Silman; Joel Sussman
Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease.
Journal of molecular neuroscience : MN 2003;20(3):369-83.
2002: Martin Weik; Jacqueline Bergès; Maria L Raves; Piet Gros; Sean McSweeney; Israel Silman; Joel Sussman; Chantal Houée-Levin; Raimond B G Ravelli
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation.
Journal of synchrotron radiation 2002;9(Pt 6):342-6.
2002: Clifford E Felder; Michal Harel; Israel Silman; Joel Sussman
Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 10 Pt 2):1765-71.
2002: Hay Dvir; H L Jiang; Dawn M Wong; Michal Harel; M Chetrit; Xu-chang He; Guang-yi Jin; G L Yu; X C Tang; Israel Silman; Dong-lu Bai; Joel Sussman
X-ray structures of Torpedo californica acetylcholinesterase complexed with (+)-huperzine A and (-)-huperzine B: structural evidence for an active site rearrangement.
Biochemistry 2002;41(35):10810-8.
2002: Irina Shin; Ellen Wachtel; Esther Roth; C Bon; Israel Silman; Lev Weiner
Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?
Protein science : a publication of the Protein Society 2002;11(8):2022-32.
2002: Gertraud Koellner; Thomas Steiner; Charles B Millard; Israel Silman; Joel Sussman
A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica.
Journal of molecular biology 2002;320(4):721-5.
2002: P Bar-On; Charles B Millard; Michal Harel; Hay Dvir; Albert Enz; Joel Sussman; Israel Silman
Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine.
Biochemistry 2002;41(11):3555-64.
2002: Hay Dvir; Dawn M Wong; Michal Harel; Xavier Barril; Modesto Orozco; F Javier Luque; Diego Muñoz-Torrero; Pelayo Camps; Terrone L Rosenberry; Israel Silman; Joel Sussman
3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates.
Biochemistry 2002;41(9):2970-81.
2001: Martin Weik; Raimond B G Ravelli; Israel Silman; Joel Sussman; Piet Gros; Jan Kroon
Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes.
Protein science : a publication of the Protein Society 2001;10(10):1953-61.
2001: C Doucet-Personeni; P D Bentley; R J Fletcher; A Kinkaid; G Kryger; B Pirard; A Taylor; R Taylor; J Taylor; R Viner; Israel Silman; Joel Sussman; Harry M Greenblatt; T Lewis
A structure-based design approach to the development of novel, reversible AChE inhibitors.
Journal of medicinal chemistry 2001;44(20):3203-15.
2001: A Nicolas; François Ferron; Lilly Toker; Joel Sussman; Israel Silman
Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 9):1348-50.
2001: Martin Weik; G Kryger; A M M Schreurs; Barend Bouma; Israel Silman; Joel Sussman; Piet Gros; Jan Kroon
Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 4):566-73.
2000: G Kryger; Michal Harel; K Giles; Lilly Toker; Baruch Velan; A Lazar; Chanoch Kronman; Dov Barak; Naomi Ariel; Avigdor Shafferman; Israel Silman; Joel Sussman
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 11):1385-94.
2000: Michal Harel; G Kryger; Terrone L Rosenberry; WD Mallender; T Lewis; R J Fletcher; J M Guss; Israel Silman; Joel Sussman
Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors.
Protein science : a publication of the Protein Society 2000;9(6):1063-72.
2000: Gertraud Koellner; G Kryger; Charles B Millard; Israel Silman; Joel Sussman; Thomas Steiner
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Journal of molecular biology 2000;296(2):713-35.
2000: Martin Weik; Raimond B G Ravelli; G Kryger; Sean McSweeney; Maria L Raves; Michal Harel; Piet Gros; Israel Silman; Jan Kroon; Joel Sussman
Specific chemical and structural damage to proteins produced by synchrotron radiation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):623-8.
1999: Harry M Greenblatt; G Kryger; T Lewis; Israel Silman; Joel Sussman
Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution.
FEBS letters 1999;463(3):321-6.
1999: Rebeca Tarrab-Hazdai; Lilly Toker; Israel Silman; Ruth Arnon
Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin.
The Biochemical journal 1999;344 Pt 3():945-51.
1999: Ruth Arnon; Israel Silman; Rebeca Tarrab-Hazdai
Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday.
Protein science : a publication of the Protein Society 1999;8(12):2553-61.
1999: Simone Botti; C E Felder; S Lifson; Joel Sussman; Israel Silman
A modular treatment of molecular traffic through the active site of cholinesterase.
Biophysical journal 1999;77(5):2430-50.
1999: Lev Weiner; Esther Roth; Yehuda Mazur; Israel Silman
Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin.
Biochemistry 1999;38(35):11401-5.
1999: Charles B Millard; G Kryger; Arie Ordentlich; Harry M Greenblatt; Michal Harel; Maria L Raves; Yoffi Segall; Dov Barak; Avigdor Shafferman; Israel Silman; Joel Sussman
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.
Biochemistry 1999;38(22):7032-9.
1999: Nicolas Morel; Suzanne Bon; Harry M Greenblatt; D van Belle; Shoshana J Wodak; Joel Sussman; Jean Massoulié; Israel Silman
Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase.
Molecular pharmacology 1999;55(6):982-92.
1999: Israel Silman; Charles B Millard; Arie Ordentlich; Harry M Greenblatt; Michal Harel; Dov Barak; Avigdor Shafferman; Joel Sussman
A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase.
Chemico-biological interactions 1999;119-120():43-52.
1999: G Kryger; Israel Silman; Joel Sussman
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Structure (London, England : 1993) 1999;7(3):297-307.
1998: Raimond B G Ravelli; Maria L Raves; Z Ren; Dominique Bourgeois; M Roth; Jan Kroon; Israel Silman; Joel Sussman
Static Laue diffraction studies on acetylcholinesterase.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 6 Pt 2):1359-66.
1998: G Kryger; Israel Silman; Joel Sussman
Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica.
Journal of physiology, Paris 1998;92(3-4):191-4.
1998: Simone Botti; C E Felder; Joel Sussman; Israel Silman
Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs.
Protein engineering 1998;11(6):415-20.
1998: Irina Shin; Israel Silman; C Bon; Lev Weiner
Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus.
Biochemistry 1998;37(13):4310-6.
1997: C E Felder; Simone Botti; S Lifson; Israel Silman; Joel Sussman
External and internal electrostatic potentials of cholinesterase models.
Journal of molecular graphics & modelling 1997;15(5):318-27, 335-7.
1997: Irina Shin; D Kreimer; Israel Silman; Lev Weiner
Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2848-52.
1997: Maria L Raves; Michal Harel; Yuan-Ping Pang; Israel Silman; Alan P Kozikowski; Joel Sussman
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nature structural biology 1997;4(1):57-63.
1996: D I Kreimer; Irina Shin; V L Shnyrov; E Villar; Israel Silman; Lev Weiner
Two partially unfolded states of Torpedo californica acetylcholinesterase.
Protein science : a publication of the Protein Society 1996;5(9):1852-64.
1996: C Faerman; Daniel R Ripoll; Suzanne Bon; Y Le Feuvre; N Morel; Jean Massoulié; Joel Sussman; Israel Silman
Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function.
FEBS letters 1996;386(1):65-71.
1996: Irina Shin; Israel Silman; L M Weiner
Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes.
Protein science : a publication of the Protein Society 1996;5(1):42-51.
1995: Michal Harel; G J Kleywegt; Raimond B G Ravelli; Israel Silman; Joel Sussman
Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.
Structure (London, England : 1993) 1995;3(12):1355-66.
1995: D I Kreimer; V L Shnyrov; E Villar; Israel Silman; Lev Weiner
Irreversible thermal denaturation of Torpedo californica acetylcholinesterase.
Protein science : a publication of the Protein Society 1995;4(11):2349-57.
1995: J Eichler; Israel Silman
The activity of an endoplasmic reticulum-localized pool of acetylcholinesterase is modulated by heat shock.
The Journal of biological chemistry 1995;270(9):4466-72.
1995: J Eichler; N Tolliday; L Toker; Israel Silman
Purification and characterization of HSP70 proteins from Torpedo electric organ.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1995;110(2):409-15.
1994: D I Kreimer; R Szosenfogel; Daniella Goldfarb; Israel Silman; Lev Weiner
Two-state transition between molten globule and unfolded states of acetylcholinesterase as monitored by electron paramagnetic resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):12145-9.
1994: D I Kreimer; E A Dolginova; Maria L Raves; Joel Sussman; Israel Silman; Lev Weiner
A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials.
Biochemistry 1994;33(48):14407-18.
1994: J Eichler; D I Kreimer; L Varon; Israel Silman; Lev Weiner
A "molten globule" of Torpedo acetylcholinesterase undergoes thiol-disulfide exchange.
The Journal of biological chemistry 1994;269(48):30093-6.
1994: Israel Silman; Michal Harel; Paul H Axelsen; Maria L Raves; Joel Sussman
Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents.
Biochemical Society transactions 1994;22(3):745-9.
1994: Michael K Gilson; Tjerk P Straatsma; J Andrew McCammon; Daniel R Ripoll; C H Faerman; Paul H Axelsen; Israel Silman; Joel Sussman
Open "back door" in a molecular dynamics simulation of acetylcholinesterase.
Science (New York, N.Y.) 1994;263(5151):1276-8.
1994: Lev Weiner; D Kreimer; E Roth; Israel Silman
Oxidative stress transforms acetylcholinesterase to a molten-globule-like state.
Biochemical and biophysical research communications 1994;198(3):915-22.
1994: Angela Mehlert; L Varon; Israel Silman; Steve W Homans; Michael A J Ferguson
Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1994;27(2):243-8.
1994: Paul H Axelsen; Michal Harel; Israel Silman; Joel Sussman
Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.
Protein science : a publication of the Protein Society 1994;3(2):188-97.
1993: Angela Mehlert; L Varon; Israel Silman; Steve W Homans; Michael A J Ferguson
Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica.
The Biochemical journal 1993;296 ( Pt 2)():473-9.
1993: Michal Harel; I Schalk; L Ehret-Sabatier; F Bouet; Maurice Goeldner; C Hirth; Paul H Axelsen; Israel Silman; Joel Sussman
Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):9031-5.
1993: Daniel R Ripoll; C H Faerman; Paul H Axelsen; Israel Silman; Joel Sussman
An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5128-32.
1993: Joel Sussman; Michal Harel; Israel Silman
Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs.
Chemico-biological interactions 1993;87(1-3):187-97.
1993: Miroslaw Cygler; Joseph D Schrag; Joel Sussman; Michal Harel; Israel Silman; M K Gentry; Bhupendra P Doctor
Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.
Protein science : a publication of the Protein Society 1993;2(3):366-82.
1993: Angela Mehlert; Israel Silman; Steve W Homans; Michael A J Ferguson
The structure of the glycosylphosphatidylinositol anchor from Torpedo californica acetylcholinesterase.
Biochemical Society transactions 1993;21(1):43S.
1992: E A Dolginova; E Roth; Israel Silman; L M Weiner
Chemical modification of Torpedo acetylcholinesterase by disulfides: appearance of a "molten globule" state.
Biochemistry 1992;31(48):12248-54.
1992: Michal Harel; Joel Sussman; krejci eric; Suzanne Bon; P Chanal; Jean Massoulié; Israel Silman
Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10827-31.
1992: David L Ollis; E Cheah; Miroslaw Cygler; B Dijkstra; Felix Frolow; S M Franken; Michal Harel; S J Remington; Israel Silman; Joseph D Schrag
The alpha/beta hydrolase fold.
Protein engineering 1992;5(3):197-211.
1991: J Eichler; L Toker; Israel Silman
Effect of heat shock on acetylcholinesterase activity in chick muscle cultures.
FEBS letters 1991;293(1-2):16-20.
1991: Michal Harel; C T Su; Felix Frolow; Yacov Ashani; Israel Silman; Joel Sussman
Refined crystal structures of "aged" and "non-aged" organophosphoryl conjugates of gamma-chymotrypsin.
Journal of molecular biology 1991;221(3):909-18.
1991: Joel Sussman; Michal Harel; Felix Frolow; C Oefner; A Goldman; L Toker; Israel Silman
Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein.
Science (New York, N.Y.) 1991;253(5022):872-9.
1991: Michal Harel; C T Su; Felix Frolow; Israel Silman; Joel Sussman
Gamma-chymotrypsin is a complex of alpha-chymotrypsin with its own autolysis products.
Biochemistry 1991;30(21):5217-25.
1991: B Espinoza; Israel Silman; Ruth Arnon; Rebeca Tarrab-Hazdai
Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni.
European journal of biochemistry / FEBS 1991;195(3):863-70.
1990: N Steinberg; E Roth; Israel Silman
Torpedo acetylcholinesterase is inactivated by thiol reagents.
Biochemistry international 1990;21(6):1043-50.
1989: J Grunwald; Yoffi Segall; E Shirin; D Waysbort; N Steinberg; Israel Silman; Yacov Ashani
Aged and non-aged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin. Preparation and comparison by 31P-NMR spectroscopy.
Biochemical pharmacology 1989;38(19):3157-68.
1989: N Steinberg; A C van der Drift; J Grunwald; Yoffi Segall; E Shirin; E Haas; Yacov Ashani; Israel Silman
Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy.
Biochemistry 1989;28(3):1248-53.
1989: N Steinberg; J Grunwald; E Roth; R August; E Haas; Yacov Ashani; Israel Silman
Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin.
Progress in clinical and biological research 1989;289():293-304.
1988: Joel Sussman; Michal Harel; Felix Frolow; L Varon; L Toker; A H Futerman; Israel Silman
Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C.
Journal of molecular biology 1988;203(3):821-3.
1988: B Espinoza; Rebeca Tarrab-Hazdai; Israel Silman; Ruth Arnon
Acetylcholinesterase in Schistosoma mansoni is anchored to the membrane via covalently attached phosphatidylinositol.
Molecular and biochemical parasitology 1988;29(2-3):171-9.
1987: Israel Silman; A H Futerman
Modes of attachment of acetylcholinesterase to the surface membrane.
European journal of biochemistry / FEBS 1987;170(1-2):11-22.
1987: B P Doctor; L Toker; E Roth; Israel Silman
Microtiter assay for acetylcholinesterase.
Analytical biochemistry 1987;166(2):399-403.
1980: G Amitai; Yacov Ashani; A Gafni; Israel Silman
New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase.
Neurochemistry international 1980;2C():199-204.