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Alcino Silva
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Living Beings
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Network (preview)
18
Frankland, Paul
12
Costa, Rui
10
Giese, Peter
10
OHNO, MASUO
9
Murphy, Geoffrey
8
Kogan, Jeffrey
8
Josselyn, Sheena
7
Matynia, Anna
7
Ehninger, Dan
7
Anagnostaras, Stephan
6
Kushner, Steven
6
Kida, Satoshi
6
Fedorov, Nikolai
5
Li, Weidong
5
Elgersma, Ype
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Publications
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Geonetwork of Alcino Silva (preview)
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All Publications
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2009: Zhou Yu; Won Jaejoon; Karlsson Mikael Guzman; Zhou Miou; Rogerson Thomas; Balaji Jayaprakash; Neve Rachael; Poirazi Panayiota; Silva Alcino J
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala.
Nature neuroscience 2009;12(11):1438-43.
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2009: Silva Alcino J; Zhou Yu; Rogerson Thomas; Shobe Justin; Balaji J
Molecular and cellular approaches to memory allocation in neural circuits.
Science (New York, N.Y.) 2009;326(5951):391-5.
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2009: Ehninger D; de Vries P J; Silva A J
From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis.
Journal of intellectual disability research : JIDR 2009;53(10):838-51.
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2009: Ehninger Dan; Silva Alcino J
Genetics and neuropsychiatric disorders: treatment during adulthood.
Nature medicine 2009;15(8):849-50.
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2009: Hutnick Leah K; Golshani Peyman; Namihira Masakasu; Xue Zhigang; Matynia Anna; Yang X William; Silva Alcino J; Schweizer Felix E; Fan Guoping
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation.
Human molecular genetics 2009;18(15):2875-88.
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2009: Lee Yong-Seok; Silva Alcino J
The molecular and cellular biology of enhanced cognition.
Nature reviews. Neuroscience 2009;10(2):126-40.
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2009: Huynh Duong P; Maalouf Marwan; Silva Alcino J; Schweizer Felix E; Pulst Stefan M
Dissociated fear and spatial learning in mice with deficiency of ataxin-2.
PloS one 2009;4(7):e6235.
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2008: Ehninger Dan; Li Weidong; Fox Kevin; Stryker Michael P; Silva Alcino J
Reversing neurodevelopmental disorders in adults.
Neuron 2008;60(6):950-60.
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2008: Cui Yijun; Costa Rui M; Murphy Geoffrey G; Elgersma Ype; Zhu Yuan; Gutmann David H; Parada Luis F; Mody Istvan; Silva Alcino J
Neurofibromin regulation of ERK signaling modulates GABA release and learning.
Cell 2008;135(3):549-60.
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2008: Ehninger Dan; Han Sangyeul; Shilyansky Carrie; Zhou Yu; Li Weidong; Kwiatkowski David J; Ramesh Vijaya; Silva Alcino J
Reversal of learning deficits in a Tsc2+/- mouse model of tuberous sclerosis.
Nature medicine 2008;14(8):843-8.
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2008: Krab Lianne C; de Goede-Bolder Arja; Aarsen Femke K; Pluijm Saskia M F; Bouman Marlies J; van der Geest Jos N; Lequin Maarten; Catsman Coriene E; Arts Willem Frans M; Kushner Steven A; Silva Alcino J; de Zeeuw Chris I; Moll Henriëtte A; Elgersma Ype
Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: a randomized controlled trial.
JAMA : the journal of the American Medical Association 2008;300(3):287-94.
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2008: Rauen Katherine A; Hefner Erin; Carrillo Kristin; Taylor Jill; Messier Laure; Aoki Yoko; Gripp Karen W; Matsubara Yoichi; Proud Virginia K; Hammond Peter; Allanson Judith E; Delrue Marie-Ange; Axelrad Marni E; Lin Angela E; Doyle Daniel A; Kerr Bronwyn; Carey John C; McCormick Frank; Silva Alcino J; Kieran Mark W; Hinek Aleksander; Nguyen Tan T; Schoyer Lisa
Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007.
American journal of medical genetics. Part A 2008;146A(9):1205-17.
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2008: Won Jaejoon; Silva Alcino J
Molecular and cellular mechanisms of memory allocation in neuronetworks.
Neurobiology of learning and memory 2008;89(3):285-92.
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2008: Kimura Ryoichi; Silva Alcino J; Ohno Masuo
Autophosphorylation of alphaCaMKII is differentially involved in new learning and unlearning mechanisms of memory extinction.
Learning & memory (Cold Spring Harbor, N.Y.) 2008;15(11):837-43.
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2008: Matynia Anna; Anagnostaras Stephan G; Wiltgen Brian J; Lacuesta Maress; Fanselow Michael S; Silva Alcino J
A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.
PloS one 2008;3(5):e2121.
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2007: Zhou Yu; Takahashi Eiki; Li Weidong; Halt Amy; Wiltgen Brian; Ehninger Dan; Li Guo-Dong; Hell Johannes W; Kennedy Mary B; Silva Alcino J
Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(50):13843-53.
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2007: Li Weidong; Zhou Yu; Jentsch J David; Brown Robert A M; Tian Xiaoli; Ehninger Dan; Hennah William; Peltonen Leena; Lönnqvist Jouko; Huttunen Matti O; Kaprio Jaakko; Trachtenberg Joshua T; Silva Alcino J; Cannon Tyrone D
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(46):18280-5.
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2007: Hojjati Mohammad Reza; van Woerden Geeske M; Tyler William J; Giese Karl Peter; Silva Alcino J; Pozzo-Miller Lucas; Elgersma Ype
Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.
Nature neuroscience 2007;10(9):1125-7.
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2007: Silva Alcino J
The science of research: the principles underlying the discovery of cognitive and other biological mechanisms.
Journal of physiology, Paris 2007;101(4-6):203-13.
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2007: Wiltgen Brian J; Silva Alcino J
Memory for context becomes less specific with time.
Learning & memory (Cold Spring Harbor, N.Y.) 2007;14(4):313-7.
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2007: Han Jin-Hee; Kushner Steven A; Yiu Adelaide P; Cole Christy J; Matynia Anna; Brown Robert A; Neve Rachael L; Guzowski John F; Silva Alcino J; Josselyn Sheena A
Neuronal competition and selection during memory formation.
Science (New York, N.Y.) 2007;316(5823):457-60.
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2006: Murphy Geoffrey G; Shah Vaibhavi; Hell Johannes W; Silva Alcino J
Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2006;14(12):1012-21.
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2006: Murphy Geoffrey G; Rahnama Nancy P; Silva Alcino J
Investigation of age-related cognitive decline using mice as a model system: behavioral correlates.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2006;14(12):1004-11.
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2006: Frankland Paul W; Ding Hoi-Ki; Takahashi Eiki; Suzuki Akinobu; Kida Satoshi; Silva Alcino J
Stability of recent and remote contextual fear memory.
Learning & memory (Cold Spring Harbor, N.Y.) 2006;13(4):451-7.
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2006: Ohno Masuo; Sametsky Evgeny A; Silva Alcino J; Disterhoft John F
Differential effects of alphaCaMKII mutation on hippocampal learning and changes in intrinsic neuronal excitability.
The European journal of neuroscience 2006;23(8):2235-40.
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2006: Acosta Maria T; Gioia Gerard A; Silva Alcino J
Neurofibromatosis type 1: new insights into neurocognitive issues.
Current neurology and neuroscience reports 2006;6(2):136-43.
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2006: Nagy Vanja; Bozdagi Ozlem; Matynia Anna; Balcerzyk Marcin; Okulski Pawel; Dzwonek Joanna; Costa Rui M; Silva Alcino J; Kaczmarek Leszek; Huntley George W
Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(7):1923-34.
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2006: Uchida S; Sakai S; Furuichi T; Hosoda H; Toyota K; Ishii T; Kitamoto A; Sekine M; Koike K; Masushige S; Murphy G; Silva A J; Kida S
Tight regulation of transgene expression by tetracycline-dependent activator and repressor in brain.
Genes, brain, and behavior 2006;5(1):96-106.
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2006: Chen Adele P; Ohno Masuo; Giese K Peter; Kühn Ralf; Chen Rachel L; Silva Alcino J
Forebrain-specific knockout of B-raf kinase leads to deficits in hippocampal long-term potentiation, learning, and memory.
Journal of neuroscience research 2006;83(1):28-38.
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2005: Li Weidong; Cui Yijun; Kushner Steven A; Brown Robert A M; Jentsch J David; Frankland Paul W; Cannon Tyrone D; Silva Alcino J
The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.
Current biology : CB 2005;15(21):1961-7.
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2005: Kushner Steven A; Elgersma Ype; Murphy Geoffrey G; Jaarsma Dick; van Woerden Geeske M; Hojjati Mohammad Reza; Cui Yijun; LeBoutillier Janelle C; Marrone Diano F; Choi Esther S; De Zeeuw Chris I; Petit Ted L; Pozzo-Miller Lucas; Silva Alcino J
Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(42):9721-34.
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2005: Costa Rui M; Drew Camilla; Silva Alcino J
Notch to remember.
Trends in neurosciences 2005;28(8):429-35.
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2005: Ohno Masuo; Tseng Wilbur; Silva Alcino J; Disterhoft John F
Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice.
Learning & memory (Cold Spring Harbor, N.Y.) 2005;12(3):211-5.
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2005: Ehninger Dan; Matynia Anna; Silva Alcino J
Trafficking in emotions.
Nature neuroscience 2005;8(5):548-50.
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2004: Murphy Geoffrey G; Fedorov Nikolai B; Giese K Peter; Ohno Masuo; Friedman Eugenia; Chen Rachel; Silva Alcino J
Increased neuronal excitability, synaptic plasticity, and learning in aged Kvbeta1.1 knockout mice.
Current biology : CB 2004;14(21):1907-15.
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2004: Wiltgen Brian J; Brown Robert A M; Talton Lynn E; Silva Alcino J
New circuits for old memories: the role of the neocortex in consolidation.
Neuron 2004;44(1):101-8.
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2004: Israely Inbal; Costa Rui M; Xie Cui Wei; Silva Alcino J; Kosik Kenneth S; Liu Xin
Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction.
Current biology : CB 2004;14(18):1657-63.
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2004: Josselyn S A; Kida S; Silva A J
Inducible repression of CREB function disrupts amygdala-dependent memory.
Neurobiology of learning and memory 2004;82(2):159-63.
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2004: Suzuki Akinobu; Josselyn Sheena A; Frankland Paul W; Masushige Shoichi; Silva Alcino J; Kida Satoshi
Memory reconsolidation and extinction have distinct temporal and biochemical signatures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(20):4787-95.
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2004: Frankland Paul W; Bontempi Bruno; Talton Lynn E; Kaczmarek Leszek; Silva Alcino J
The involvement of the anterior cingulate cortex in remote contextual fear memory.
Science (New York, N.Y.) 2004;304(5672):881-3.
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2004: Brown Robert; Silva Alcino J
Molecular and cellular cognition; the unraveling of memory retrieval.
Cell 2004;117(1):3-4.
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2004: Frankland Paul W; Josselyn Sheena A; Anagnostaras Stephan G; Kogan Jeffrey H; Takahashi Eiki; Silva Alcino J
Consolidation of CS and US representations in associative fear conditioning.
Hippocampus 2004;14(5):557-69.
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2003: Wang Jianpeng; Ren Keqin; Pérez Javier; Silva Alcino J; Peña de Ortiz Sandra
The antimetabolite ara-CTP blocks long-term memory of conditioned taste aversion.
Learning & memory (Cold Spring Harbor, N.Y.) 2003;10(6):503-9.
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2003: Costa Rui M; Honjo Tasuku; Silva Alcino J
Learning and memory deficits in Notch mutant mice.
Current biology : CB 2003;13(15):1348-54.
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2003: Bozon Bruno; Kelly Aine; Josselyn Sheena A; Silva Alcino J; Davis Sabrina; Laroche Serge
MAPK, CREB and zif268 are all required for the consolidation of recognition memory.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1432):805-14.
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2003: Frankland Paul W; Ohno Masuo; Takahashi Eiki; Chen Adele R; Costa Rui M; Kushner Steven A; Silva Alcino J
Pharmacologically regulated induction of silent mutations (PRISM): combined pharmacological and genetic approaches for learning and memory.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2003;9(2):104-9.
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2003: Dhaka Ajay; Costa Rui M; Hu Hailiang; Irvin Dwain K; Patel Apoor; Kornblum Harley I; Silva Alcino J; O'Dell Thomas J; Colicelli John
The RAS effector RIN1 modulates the formation of aversive memories.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(3):748-57.
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2003: Costa Rui M; Silva Alcino J
Mouse models of neurofibromatosis type I: bridging the GAP.
Trends in molecular medicine 2003;9(1):19-23.
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2003: Silva Alcino J
Molecular and cellular cognitive studies of the role of synaptic plasticity in memory.
Journal of neurobiology 2003;54(1):224-37.
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2003: Anagnostaras Stephan G; Murphy Geoffrey G; Hamilton Susan E; Mitchell Scott L; Rahnama Nancy P; Nathanson Neil M; Silva Alcino J
Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice.
Nature neuroscience 2003;6(1):51-8.
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2002: Elgersma Ype; Fedorov Nikolai B; Ikonen Sami; Choi Esther S; Elgersma Minetta; Carvalho Ofelia M; Giese Karl Peter; Silva Alcino J
Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
Neuron 2002;36(3):493-505.
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2002: Taha Sharif; Hanover Jessica L; Silva Alcino J; Stryker Michael P
Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity.
Neuron 2002;36(3):483-91.
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2002: Costa Rui M; Silva Alcino J
Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1.
Journal of child neurology 2002;17(8):622-6; discussion 627-9, 646-51.
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2002: Silva Alcino J; Josselyn Sheena A
The molecules of forgetfulness.
Nature 2002;418(6901):929-30.
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2002: Ohno Masuo; Frankland Paul W; Silva Alcino J
A pharmacogenetic inducible approach to the study of NMDA/alphaCaMKII signaling in synaptic plasticity.
Current biology : CB 2002;12(8):654-6.
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2002: Kida Satoshi; Josselyn Sheena A; Peña de Ortiz Sandra; Kogan Jeffrey H; Chevere Itzamarie; Masushige Shoichi; Silva Alcino J
CREB required for the stability of new and reactivated fear memories.
Nature neuroscience 2002;5(4):348-55.
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2002: Givogri Maria I; Costa Rui M; Schonmann Vilma; Silva Alcino J; Campagnoni Anthony T; Bongarzone Ernesto R
Central nervous system myelination in mice with deficient expression of Notch1 receptor.
Journal of neuroscience research 2002;67(3):309-20.
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2002: Costa Rui M; Federov Nikolai B; Kogan Jeff H; Murphy Geoffrey G; Stern Joel; Ohno Masuo; Kucherlapati Raju; Jacks Tyler; Silva Alcino J
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.
Nature 2002;415(6871):526-30.
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2002: Matynia Anna; Kushner Steven A; Silva Alcino J
Genetic approaches to molecular and cellular cognition: a focus on LTP and learning and memory.
Annual review of genetics 2002;36():687-720.
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2001: Ohno M; Frankland P W; Chen A P; Costa R M; Silva A J
Inducible, pharmacogenetic approaches to the study of learning and memory.
Nature neuroscience 2001;4(12):1238-43.
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2001: Matynia A; Anagnostaras S G; Silva A J
Weaving the molecular and cognitive strands of memory.
Neuron 2001;32(4):557-9.
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2001: Giese K P; Friedman E; Telliez J B; Fedorov N B; Wines M; Feig L A; Silva A J
Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1).
Neuropharmacology 2001;41(6):791-800.
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2001: Pham T A; Rubenstein J L; Silva A J; Storm D R; Stryker M P
The CRE/CREB pathway is transiently expressed in thalamic circuit development and contributes to refinement of retinogeniculate axons.
Neuron 2001;31(3):409-20.
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2001: Frankland P W; O'Brien C; Ohno M; Kirkwood A; Silva A J
Alpha-CaMKII-dependent plasticity in the cortex is required for permanent memory.
Nature 2001;411(6835):309-13.
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2001: Hamilton S E; Hardouin S N; Anagnostaras S G; Murphy G G; Richmond K N; Silva A J; Feigl E O; Nathanson N M
Alteration of cardiovascular and neuronal function in M1 knockout mice.
Life sciences 2001;68(22-23):2489-93.
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2001: Costa R M; Yang T; Huynh D P; Pulst S M; Viskochil D H; Silva A J; Brannan C I
Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1.
Nature genetics 2001;27(4):399-405.
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2000: Ferguson G D; Anagnostaras S G; Silva A J; Herschman H R
Deficits in memory and motor performance in synaptotagmin IV mutant mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5598-603.
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2000: Silva A J; Elgersma Y; Costa R M
Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders.
Biological psychiatry 2000;47(3):200-9.
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2000: Anagnostaras S G; Josselyn S A; Frankland P W; Silva A J
Computer-assisted behavioral assessment of Pavlovian fear conditioning in mice.
Learning & memory (Cold Spring Harbor, N.Y.) 2000;7(1):58-72.
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2000: Kogan J H; Frankland P W; Silva A J
Long-term memory underlying hippocampus-dependent social recognition in mice.
Hippocampus 2000;10(1):47-56.
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1999: Silva A J; Murphy G G
cAMP and memory: a seminal lesson from Drosophila and Aplysia.
Brain research bulletin 1999;50(5-6):441-2.
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1999: Elgersma Y; Silva A J
Molecular mechanisms of synaptic plasticity and memory.
Current opinion in neurobiology 1999;9(2):209-13.
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1999: Cho Y H; Friedman E; Silva A J
Ibotenate lesions of the hippocampus impair spatial learning but not contextual fear conditioning in mice.
Behavioural brain research 1999;98(1):77-87.
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1998: Silva A J; Elgersma Y; Friedman E; Stern J; Kogan J
A mouse model for learning and memory defects associated with neurofibromatosis type I.
Pathologie-biologie 1998;46(9):697-8.
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1998: Giese K P; Storm J F; Reuter D; Fedorov N B; Shao L R; Leicher T; Pongs O; Silva A J
Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning.
Learning & memory (Cold Spring Harbor, N.Y.) 1998;5(4-5):257-73.
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1998: Frankland P W; Cestari V; Filipkowski R K; McDonald R J; Silva A J
The dorsal hippocampus is essential for context discrimination but not for contextual conditioning.
Behavioral neuroscience 1998;112(4):863-74.
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1998: Silva A J; Giese K P; Fedorov N B; Frankland P W; Kogan J H
Molecular, cellular, and neuroanatomical substrates of place learning.
Neurobiology of learning and memory 1998;70(1-2):44-61.
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1998: Giese K P; Fedorov N B; Filipkowski R K; Silva A J
Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.
Science (New York, N.Y.) 1998;279(5352):870-3.
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1998: Silva A J; Kogan J H; Frankland P W; Kida S
CREB and memory.
Annual review of neuroscience 1998;21():127-48.
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1997: Silva A J; Frankland P W; Marowitz Z; Friedman E; Laszlo G S; Cioffi D; Jacks T; Bourtchuladze R;
A mouse model for the learning and memory deficits associated with neurofibromatosis type I.
Nature genetics 1997;15(3):281-4.
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1997: Kogan J H; Frankland P W; Blendy J A; Coblentz J; Marowitz Z; Schütz G; Silva A J
Spaced training induces normal long-term memory in CREB mutant mice.
Current biology : CB 1997;7(1):1-11.
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1997: Silva A J; Smith A M; Giese K P
Gene targeting and the biology of learning and memory.
Annual review of genetics 1997;31():527-46.
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1996: Silva A J; Rosahl T W; Chapman P F; Marowitz Z; Friedman E; Frankland P W; Cestari V; Cioffi D; Südhof T C; Bourtchuladze R
Impaired learning in mice with abnormal short-lived plasticity.
Current biology : CB 1996;6(11):1509-18.
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1996: Gordon J A; Cioffi D; Silva A J; Stryker M P
Deficient plasticity in the primary visual cortex of alpha-calcium/calmodulin-dependent protein kinase II mutant mice.
Neuron 1996;17(3):491-9.
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1996: Silva A J; Fedorov N; Kogan J; Frankland P; Coblentz J; Lundsten R; Friedman E; Smith A; Cho Y; Giese K P
Genetic analysis of function and dysfunction in the central nervous system.
Cold Spring Harbor symposia on quantitative biology 1996;61():239-46.
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1995: Chapman P F; Frenguelli B G; Smith A; Chen C M; Silva A J
The alpha-Ca2+/calmodulin kinase II: a bidirectional modulator of presynaptic plasticity.
Neuron 1995;14(3):591-7.
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1994: Bourtchuladze R; Frenguelli B; Blendy J; Cioffi D; Schutz G; Silva A J
Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.
Cell 1994;79(1):59-68.
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1994: Silva A J; Giese K P
Plastic genes are in!
Current opinion in neurobiology 1994;4(3):413-20.
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