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Marcy Silver

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Mariangela Palladino; Ilaria Gatto; Valentina Neri; Stefania Straino; Marcy Silver; Alessandra Tritarelli; Andrea Piccioni; Roy Smith; Eleonora Gaetani; Douglas Losordo; Filippo Crea; Maurizio Capogrossi; Roberto Pola
Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia.
Raj Kishore; Tengiz Tkebuchava; Sharath P Sasi; Marcy Silver; Hu-Ya Gilbert; Young-Sup Yoon; Hee-Young Park; Tina Thorne; Douglas Losordo; David Goukassian
Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium.
Sabyasachi Sen; Juan Merchan; Jarrod Dean; Masaaki Ii; Mary Gavin; Marcy Silver; Tengiz Tkebuchava; Young-sup Yoon; John Rasko; Ryuichi Aikawa
Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction.

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2011: Mariangela Palladino; Ilaria Gatto; Valentina Neri; Stefania Straino; Marcy Silver; Alessandra Tritarelli; Andrea Piccioni; Roy Smith; Eleonora Gaetani; Douglas Losordo; Filippo Crea; Maurizio Capogrossi; Roberto Pola
Pleiotropic beneficial effects of sonic hedgehog gene therapy in an experimental model of peripheral limb ischemia.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(4):658-66.
2011: Raj Kishore; Tengiz Tkebuchava; Sharath P Sasi; Marcy Silver; Hu-Ya Gilbert; Young-Sup Yoon; Hee-Young Park; Tina Thorne; Douglas Losordo; David Goukassian
Tumor necrosis factor-α signaling via TNFR1/p55 is deleterious whereas TNFR2/p75 signaling is protective in adult infarct myocardium.
Advances in experimental medicine and biology 2011;691():433-48.
2010: Sabyasachi Sen; Juan Merchan; Jarrod Dean; Masaaki Ii; Mary Gavin; Marcy Silver; Tengiz Tkebuchava; Young-sup Yoon; John Rasko; Ryuichi Aikawa
Autologous transplantation of endothelial progenitor cells genetically modified by adeno-associated viral vector delivering insulin-like growth factor-1 gene after myocardial infarction.
Human gene therapy 2010;21(10):1327-34.
2009: Yun Bian; Maoyun Sun; Marcy Silver; Kalon K L Ho; Mark A Marchionni; Anthony O Caggiano; James R Stone; Ivo Amende; Thomas G Hampton; James P Morgan; Xinhua Yan
Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins.
American journal of physiology. Heart and circulatory physiology 2009;297(6):H1974-83.
2009: Jin-Ok Jeong; Mee-Ohk Kim; Hyongbum Kim; Min-Young Lee; Sung-Whan Kim; Masaaki Ii; Jung-Uek Lee; Jiyoon Lee; Yong Jin Choi; Hyun-Jai Cho; Namho Lee; Marcy Silver; Andrea Wecker; Dong-Wook Kim; Young-sup Yoon
Dual angiogenic and neurotrophic effects of bone marrow-derived endothelial progenitor cells on diabetic neuropathy.
Circulation 2009;119(5):699-708.
2007: Rajasingh Johnson; Evelyn Bord; Gangjian Qin; Masaaki Ii; Marcy Silver; Hiromichi Hamada; Deepali Ahluwalia; David Goukassian; Yan Zhu; Douglas Losordo; Raj Kishore
Enhanced voluntary alcohol consumption after estrogen supplementation negates estrogen-mediated vascular repair in ovariectomized mice.
Endocrinology 2007;148(8):3618-24.
2007: David Goukassian; Gangjian Qin; Christine Dolan; Toshinori Murayama; Marcy Silver; Cynthia Curry; Elizabeth Eaton; Corinne Luedemann; Hong Ma; Takayuki Asahara; Victor Zak; Shanu Mehta; Aaron Burg; Tina Thorne; Raj Kishore; Douglas Losordo
Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization.
Circulation 2007;115(6):752-62.
2007: Kengo Kusano; Yoshiaki Tsutsumi; Jarrod Dean; Mary Gavin; Hong Ma; Marcy Silver; Tina Thorne; Yan Zhu; Douglas Losordo; Ryuichi Aikawa
Long-term stable expression of human growth hormone by rAAV promotes myocardial protection post-myocardial infarction.
Journal of molecular and cellular cardiology 2007;42(2):390-9.
2007: Rudolf Kirchmair; Anne B Tietz; Eleftheria Panagiotou; Dirk H Walter; Marcy Silver; Young-sup Yoon; Peter Schratzberger; Alberto Weber; Kengo Kusano; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):69-75.
2006: Hiromichi Hamada; Myeong Kon Kim; Atsushi Iwakura; Masaaki Ii; Tina Thorne; Gangjian Qin; Jun Asai; Yoshiaki Tsutsumi; Haruki Sekiguchi; Marcy Silver; Andrea Wecker; Evelyn Bord; Yan Zhu; Raj Kishore; Douglas Losordo
Estrogen receptors alpha and beta mediate contribution of bone marrow-derived endothelial progenitor cells to functional recovery after myocardial infarction.
Circulation 2006;114(21):2261-70.
2006: Atsuhiko Kawamoto; Hiroto Iwasaki; Kengo Kusano; Toshinori Murayama; Akira Oyamada; Marcy Silver; Christine Hulbert; Mary Gavin; Allison Hanley; Hong Ma; Marianne Kearney; Victor Zak; Takayuki Asahara; Douglas Losordo
CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells.
Circulation 2006;114(20):2163-9.
2006: Brent D Wilson; Masaaki Ii; Kye Won Park; Arminda Suli; Lise K Sorensen; Fréderic Larrieu-Lahargue; Lisa D Urness; Wonhee Suh; Jun Asai; Gerhardus A H Kock; Tina Thorne; Marcy Silver; Kirk R Thomas; Chi-Bin Chien; Douglas Losordo; Dean Y Li
Netrins promote developmental and therapeutic angiogenesis.
Science (New York, N.Y.) 2006;313(5787):640-4.
2006: Gangjian Qin; Raj Kishore; Christine Dolan; Marcy Silver; Andrea Wecker; Corinne Luedemann; Tina Thorne; Allison Hanley; Cynthia Curry; Lindsay Heyd; Deepika Dinesh; Marianne Kearney; Fabio Martelli; Toshinori Murayama; David Goukassian; Yan Zhu; Douglas Losordo
Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(29):11015-20.
2006: Atsushi Iwakura; Shubha Shastry; Corinne Luedemann; Hiromichi Hamada; Atsuhiko Kawamoto; Raj Kishore; Yan Zhu; Gangjian Qin; Marcy Silver; Tina Thorne; Liz Eaton; Haruchika Masuda; Takayuki Asahara; Douglas Losordo
Estradiol enhances recovery after myocardial infarction by augmenting incorporation of bone marrow-derived endothelial progenitor cells into sites of ischemia-induced neovascularization via endothelial nitric oxide synthase-mediated activation of matrix metalloproteinase-9.
Circulation 2006;113(12):1605-14.
2006: Masaaki Ii; Hideya Takenaka; Jun Asai; Kayoko Ibusuki; Yusuke Mizukami; Kazuichi Maruyama; Young-sup Yoon; Andrea Wecker; Corinne Luedemann; Elizabeth Eaton; Marcy Silver; Tina Thorne; Douglas Losordo
Endothelial progenitor thrombospondin-1 mediates diabetes-induced delay in reendothelialization following arterial injury.
Circulation research 2006;98(5):697-704.
2006: Satoshi Shintani; Kengo Kusano; Masaaki Ii; Atsushi Iwakura; Lindsay Heyd; Cynthia Curry; Andrea Wecker; Mary Gavin; Hong Ma; Marianne Kearney; Marcy Silver; Tina Thorne; Toyoaki Murohara; Douglas Losordo
Synergistic effect of combined intramyocardial CD34+ cells and VEGF2 gene therapy after MI.
Nature clinical practice. Cardiovascular medicine 2006;3 Suppl 1():S123-8.
2006: Gangjian Qin; Masaaki Ii; Marcy Silver; Andrea Wecker; Evelyn Bord; Hong Ma; Mary Gavin; David Goukassian; Young-sup Yoon; Thalia Papayannopoulou; Takayuki Asahara; Marianne Kearney; Tina Thorne; Cynthia Curry; Liz Eaton; Lindsay Heyd; Deepika Dinesh; Raj Kishore; Yan Zhu; Douglas Losordo
Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization.
The Journal of experimental medicine 2006;203(1):153-63.
2005: Kengo Fukushima Kusano; Roberto Pola; Toshinori Murayama; Cynthia Curry; Atsuhiko Kawamoto; Atsushi Iwakura; Satoshi Shintani; Masaaki Ii; Jun Asai; Tengiz Tkebuchava; Tina Thorne; Hideya Takenaka; Ryuichi Aikawa; David Goukassian; Patrick Von Samson; Hiromichi Hamada; Young-sup Yoon; Marcy Silver; Elizabeth Eaton; Hong Ma; Lindsay Heyd; Marianne Kearney; William Munger; Jeffery A Porter; Raj Kishore; Douglas Losordo
Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling.
Nature medicine 2005;11(11):1197-204.
2005: Raj Kishore; Gangjian Qin; Corinne Luedemann; Evelyn Bord; Allison Hanley; Marcy Silver; Mary Gavin; Young-sup Yoon; David Goukassian; David Goukassain; Douglas Losordo
The cytoskeletal protein ezrin regulates EC proliferation and angiogenesis via TNF-alpha-induced transcriptional repression of cyclin A.
The Journal of clinical investigation 2005;115(7):1785-96.
2005: Rudolf Kirchmair; Dirk H Walter; Masaaki Ii; Kilian Rittig; Anne B Tietz; Toshinori Murayama; Costanza Emanueli; Marcy Silver; Andrea Wecker; Carole Amant; Peter Schratzberger; Young-sup Yoon; Alberto Weber; Eleftheria Panagiotou; Kenneth M Rosen; Ferdinand H Bahlmann; Lester S Adelman; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.
Circulation 2005;111(20):2662-70.
2005: MARTA BOSCH; Roberto Pola; Andrea Wecker; Marcy Silver; Alberto Weber; Corinne Luedemann; Cynthia Curry; Toshinori Murayama; Marianne Kearney; Young-sup Yoon; M Rene Malinow; Takayuki Asahara; Jeffrey M Isner; Douglas Losordo
Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia.
Vascular medicine (London, England) 2005;10(1):15-22.
2004: Kengo Fukushima Kusano; Karen L Allendoerfer; William Munger; Roberto Pola; MARTA BOSCH; Rudolf Kirchmair; Young-sup Yoon; Cynthia Curry; Marcy Silver; Marianne Kearney; Takayuki Asahara; Douglas Losordo
Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):2102-7.
2004: Atsuhiko Kawamoto; Toshinori Murayama; Kengo Kusano; Masaaki Ii; Tengiz Tkebuchava; Satoshi Shintani; Atsushi Iwakura; Ingrid Johnson; Patrick Von Samson; Allison Hanley; Mary Gavin; Cynthia Curry; Marcy Silver; Hong Ma; Marianne Kearney; Douglas Losordo
Synergistic effect of bone marrow mobilization and vascular endothelial growth factor-2 gene therapy in myocardial ischemia.
Circulation 2004;110(11):1398-405.
2004: Rudolf Kirchmair; Margot Egger; Dirk H Walter; Wolfgang Eisterer; Andreas Niederwanger; Ewald Woell; Markus Nagl; Michael T Pedrini; Toshinori Murayama; Silke Frauscher; Allison Hanley; Marcy Silver; Marianne Brodmann; Wolfgang Sturm; Reiner Fischer-Colbrie; Douglas Losordo; Josef R Patsch; Peter Schratzberger
Secretoneurin, an angiogenic neuropeptide, induces postnatal vasculogenesis.
Circulation 2004;110(9):1121-7.
2004: Dirk H Walter; Manfred Cejna; Larry J Diaz-Sandoval; Sean Willis; Laura Kirkwood; Peter W Stratford; Anne B Tietz; Rudolf Kirchmair; Marcy Silver; Cynthia Curry; Andrea Wecker; Young-sup Yoon; Regina Heidenreich; Allison Hanley; Marianne Kearney; Fermin O Tio; Patrik Kuenzler; Jeffrey M Isner; Douglas Losordo
Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis.
Circulation 2004;110(1):36-45.
2004: Rudolf Kirchmair; Roland Gander; Margot Egger; Allison Hanley; Marcy Silver; Andreas Ritsch; Toshinori Murayama; Nicole Kaneider; Wolfgang Sturm; Marianne Kearny; Reiner Fischer-Colbrie; Brigitte Kircher; Hannes Gaenzer; Christian Wiedermann; Allan H Ropper; Douglas Losordo; Josef R Patsch; Peter Schratzberger
The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo.
Circulation 2004;109(6):777-83.
2003: Jun-ichi Yamaguchi; Kengo Fukushima Kusano; Osamu Masuo; Atsuhiko Kawamoto; Marcy Silver; Satoshi Murasawa; MARTA BOSCH; Haruchika Masuda; Douglas Losordo; Jeffrey M Isner; Takayuki Asahara
Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization.
Circulation 2003;107(9):1322-8.
2003: Young-sup Yoon; Toshinori Murayama; Edwin Gravereaux; Tengiz Tkebuchava; Marcy Silver; Cynthia Curry; Andrea Wecker; Rudolf Kirchmair; Chun Song Hu; Marianne Kearney; Alan Ashare; David G Jackson; Hajime Kubo; Jeffrey M Isner; Douglas Losordo
VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.
The Journal of clinical investigation 2003;111(5):717-25.
2003: Atsuhiko Kawamoto; Tengiz Tkebuchava; Jun-ichi Yamaguchi; Hiromi Nishimura; Young-sup Yoon; Charles E Milliken; Shigeki Uchida; Osamu Masuo; Hideki Iwaguro; Hong Ma; Allison Hanley; Marcy Silver; Marianne Kearney; Douglas Losordo; Jeffrey M Isner; Takayuki Asahara
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia.
Circulation 2003;107(3):461-8.
2002: Satoshi Murasawa; Joan Llevadot; Marcy Silver; Jeffrey M Isner; Douglas Losordo; Takayuki Asahara
Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells.
Circulation 2002;106(9):1133-9.
2002: Dirk H Walter; Kilian Rittig; Ferdinand H Bahlmann; Rudolf Kirchmair; Marcy Silver; Toshinori Murayama; Hiromi Nishimura; Douglas Losordo; Takayuki Asahara; Jeffrey M Isner
Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.
Circulation 2002;105(25):3017-24.
2002: Hideki Iwaguro; Jun-ichi Yamaguchi; Christoph Kalka; Satoshi Murasawa; Haruchika Masuda; Shin-ichiro Hayashi; Marcy Silver; Tong Li; Jeffrey M Isner; Takayuki Asahara
Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration.
Circulation 2002;105(6):732-8.
2001: David Goukassian; Antonio Díez-Juan; T Asahara; P Schratzberger; Marcy Silver; T Murayama; Jeffrey M Isner; Vicente Andrés
Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1877-85.
2001: Roberto Pola; Leona E Ling; Marcy Silver; M J Corbley; Marianne Kearney; R Blake Pepinsky; R Shapiro; Frederick R Taylor; Darren P Baker; Takayuki Asahara; Jeffrey M Isner
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.
Nature medicine 2001;7(6):706-11.
2001: Peter Schratzberger; Dirk H Walter; Kilian Rittig; Ferdinand H Bahlmann; Roberto Pola; Cynthia Curry; Marcy Silver; J G Krainin; David H Weinberg; Allan H Ropper; Jeffrey M Isner
Reversal of experimental diabetic neuropathy by VEGF gene transfer.
The Journal of clinical investigation 2001;107(9):1083-92.
2001: Atsuhiko Kawamoto; H C Gwon; Hideki Iwaguro; Jun-ichi Yamaguchi; Shigeki Uchida; Haruchika Masuda; Marcy Silver; Hong Ma; Marianne Kearney; Jeffrey M Isner; Takayuki Asahara
Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia.
Circulation 2001;103(5):634-7.
2000: Peter Schratzberger; G Schratzberger; Marcy Silver; Cynthia Curry; Marianne Kearney; M Magner; J Alroy; Lester Adelman; David H Weinberg; A H Ropper; Jeffrey M Isner
Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy.
Nature medicine 2000;6(4):405-13.
2000: C Kalka; H Masuda; T Takahashi; W M Kalka-Moll; Marcy Silver; Marianne Kearney; T Li; Jeffrey M Isner; T Asahara
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3422-7.
1999: Takayuki Asahara; H Masuda; T Takahashi; C Kalka; C Pastore; Marcy Silver; M Kearne; M Magner; Jeffrey M Isner
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization.
Circulation research 1999;85(3):221-8.
1999: Takayuki Asahara; Tomono Takahashi; Haruchika Masuda; Christoph Kalka; D Chen; Hideki Iwaguro; Y Inai; Marcy Silver; Jeffrey M Isner
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells.
The EMBO journal 1999;18(14):3964-72.
1999: thierry couffinhal; Marcy Silver; Marianne Kearney; A Sullivan; B Witzenbichler; M Magner; B Annex; K Peters; Jeffrey M Isner
Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-/- mice.
Circulation 1999;99(24):3188-98.
1999: JE Fabre; Alain Rivard; M Magner; Marcy Silver; Jeffrey M Isner
Tissue inhibition of angiotensin-converting enzyme activity stimulates angiogenesis in vivo.
Circulation 1999;99(23):3043-9.
1999: T Takahashi; C Kalka; H Masuda; D Chen; Marcy Silver; Marianne Kearney; M Magner; Jeffrey M Isner; Takayuki Asahara
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
Nature medicine 1999;5(4):434-8.
1999: Alain Rivard; Marcy Silver; D Chen; Marianne Kearney; M Magner; B Annex; K Peters; Jeffrey M Isner
Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.
The American journal of pathology 1999;154(2):355-63.
1999: Alain Rivard; JE Fabre; Marcy Silver; D Chen; Toyoaki Murohara; Marianne Kearney; M Magner; Takayuki Asahara; Jeffrey M Isner
Age-dependent impairment of angiogenesis.
Circulation 1999;99(1):111-20.
1998: B Witzenbichler; Takayuki Asahara; Toyoaki Murohara; Marcy Silver; Ioakim Spyridopoulos; M Magner; Nicole Principe; Marianne Kearney; J S Hu; Jeffrey M Isner
Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia.
The American journal of pathology 1998;153(2):381-94.
1998: thierry couffinhal; Marcy Silver; L P Zheng; Marianne Kearney; B Witzenbichler; Jeffrey M Isner
Mouse model of angiogenesis.
The American journal of pathology 1998;152(6):1667-79.
1998: T Murohara; T Asahara; Marcy Silver; C Bauters; H Masuda; C Kalka; Marianne Kearney; D Chen; James Symes; M C Fishman; P L Huang; Jeffrey M Isner
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
The Journal of clinical investigation 1998;101(11):2567-78.
1998: Eric Van Belle; B Witzenbichler; D Chen; Marcy Silver; L Chang; R Schwall; Jeffrey M Isner
Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis.
Circulation 1998;97(4):381-90.
1998: M Sata; H Perlman; Daniel A Muruve; Marcy Silver; M Ikebe; Towia Libermann; Peter Oettgen; Kenneth Walsh
Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1213-7.
1998: T Murohara; J R Horowitz; Marcy Silver; Yukio Tsurumi; D Chen; A Sullivan; Jeffrey M Isner
Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.
Circulation 1998;97(1):99-107.
1997: Yukio Tsurumi; Marianne Kearney; D Chen; Marcy Silver; S Takeshita; J Yang; James Symes; Jeffrey M Isner
Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene.
Circulation 1997;96(9 Suppl):II-382-8.
1997: Eric Van Belle; Alain Rivard; D Chen; Marcy Silver; S Bunting; N Ferrara; James Symes; C Bauters; Jeffrey M Isner
Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.
Circulation 1997;96(8):2667-74.
1997: Takayuki Asahara; Toyoaki Murohara; A Sullivan; Marcy Silver; R van der Zee; T Li; B Witzenbichler; G Schatteman; Jeffrey M Isner
Isolation of putative progenitor endothelial cells for angiogenesis.
Science (New York, N.Y.) 1997;275(5302):964-7.