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Gary Silverman

Research Profile

Chemicals & Drugs

Concepts & Ideas

Anatomy

Chromosomes, Human, Pair 18

Genes & Molecular Sequences

Amino Acid Sequences

Procedures

Living Beings

Mouse

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Yeast Artificial Chromosomes

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Publications

TOP 3
Sangeeta R Bhatia; Cavita K Chotoo; Thomas P Conrads; Nathan J Graf; Brian L Hood; Mark T Miedel; Gary A Silverman; Cliff J Luke
Using C. elegans to identify the protease targets of serpins in vivo.
James C Whisstock; Gary A Silverman; Phillip I Bird; Stephen P Bottomley; Petra Van Damme; Cliff J Luke; Stephen C Pak; Jean-Marc Reichhart; James A Huntington
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.
Gary A Silverman; Cliff J Luke; Sangeeta R Bhatia; Olivia S Long; Anne C Vetica; David H Perlmutter; Stephen C Pak
Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.

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All Publications

2011: Sangeeta R Bhatia; Cavita K Chotoo; Thomas P Conrads; Nathan J Graf; Brian L Hood; Mark T Miedel; Gary A Silverman; Cliff J Luke
Using C. elegans to identify the protease targets of serpins in vivo.
Methods in enzymology 2011;499():283-99.
2010: James C Whisstock; Gary A Silverman; Phillip I Bird; Stephen P Bottomley; Petra Van Damme; Cliff J Luke; Stephen C Pak; Jean-Marc Reichhart; James A Huntington
Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions.
The Journal of biological chemistry 2010;285(32):24307-12.
2009: Gary A Silverman; Cliff J Luke; Sangeeta R Bhatia; Olivia S Long; Anne C Vetica; David H Perlmutter; Stephen C Pak
Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans.
Pediatric research 2009;65(1):10-8.
2007: Poh Chee Ong; Sheena McGowan; Mary C Pearce; James Irving; Wan-Ting Kan; Sergei A Grigoryev; Boris Turk; Gary A Silverman; Klaudia Brix; Stephen P Bottomley; James C Whisstock; Robert N Pike
DNA accelerates the inhibition of human cathepsin V by serpins.
The Journal of biological chemistry 2007;282(51):36980-6.
2007: Cliff J Luke; Stephen C Pak; Yuko S Askew; Terra L Naviglia; David J Askew; Shila M Nobar; Anne C Vetica; Olivia S Long; simon simon watkins; Donna B Stolz; Robert Barstead; Gary L Moulder; Dieter Brömme; Gary A Silverman
An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury.
Cell 2007;130(6):1108-19.
2007: David J Askew; Sule Cataltepe; Vasantha Kumar; Christopher Edwards; Serena M Pace; Rica N Howarth; Stephen C Pak; Yuko S Askew; Dieter Brömme; Cliff J Luke; James C Whisstock; Gary A Silverman
SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change.
The Journal of biological chemistry 2007;282(34):24948-60.
2006: Stephen C Pak; Christopher Tsu; Cliff J Luke; Yuko S Askew; Gary A Silverman
The Caenorhabditis elegans muscle specific serpin, SRP-3, neutralizes chymotrypsin-like serine peptidases.
Biochemistry 2006;45(14):4474-80.
2006: Ruby H P Law; Qingwei Zhang; Sheena McGowan; Ashley M Buckle; Gary A Silverman; Wilson Wong; Carlos J Rosado; Chris G Langendorf; Robert N Pike; Phillip I Bird; James C Whisstock
An overview of the serpin superfamily.
Genome biology 2006;7(5):216.
2006: Torahiko Nakashima; Ryuji Yasumatsu; Yuichiro Kuratomi; Muneyuki Masuda; Takashi Kuwano; Satoshi Toh; Toshiro Umezaki; Sule Cataltepe; Gary A Silverman; Shizuo Komune
Role of squamous cell carcinoma antigen 1 expression in the invasive potential of head and neck squamous cell carcinoma.
Head & neck 2006;28(1):24-30.
2006: Cliff J Luke; Stephen C Pak; David J Askew; Yuko S Askew; Justin E Smith; Gary A Silverman
Selective conservation of the RSL-encoding, proteinase inhibitory-type, clade L serpins in Caenorhabditis species.
Frontiers in bioscience : a journal and virtual library 2006;11():581-94.
2005: Shinsuke Yasuda; Nasa Morokawa; GUANG WILLIAM WONG; Andrea Rossi; Mallur S Madhusudhan; Andrej Sali; Yuko S Askew; Roberto Adachi; Gary A Silverman; Steven A Krilis; Richard L Stevens
Urokinase-type plasminogen activator is a preferred substrate of the human epithelium serine protease tryptase epsilon/PRSS22.
Blood 2005;105(10):3893-901.
2004: Elisabeth B Cole; David Miller; David Rometo; Robert M Greenberg; Dieter Brömme; Sule Cataltepe; Stephen C Pak; David R Mills; Gary A Silverman; Cliff J Luke
Identification and activity of a lower eukaryotic serine proteinase inhibitor (serpin) from Cyanea capillata: analysis of a jellyfish serpin, jellypin.
Biochemistry 2004;43(37):11750-9.
2004: David J Askew; Yuko S Askew; Yukari Kato; Russell F Turner; Ken Dewar; Jessica A Lehoczky; Gary A Silverman
Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.
Genomics 2004;84(1):176-84.
2004: David J Askew; Yuko S Askew; Yukari Kato; Cliff J Luke; Stephen C Pak; Dieter Brömme; Gary A Silverman
The amplified mouse squamous cell carcinoma antigen gene locus contains a serpin (Serpinb3b) that inhibits both papain-like cysteine and trypsin-like serine proteinases.
Genomics 2004;84(1):166-75.
2004: Stephen C Pak; Vasantha Kumar; Christopher Tsu; Cliff J Luke; Yuko S Askew; David J Askew; David R Mills; Dieter Brömme; Gary A Silverman
SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.
The Journal of biological chemistry 2004;279(15):15448-59.
2004: Gary A Silverman; James C Whisstock; David J Askew; Stephen C Pak; Cliff J Luke; Sule Cataltepe; James Irving; Phillip I Bird
Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.
Cellular and molecular life sciences : CMLS 2004;61(3):301-25.
2004: Arumugam Jayakumar; Sule Cataltepe; Ya'an Kang; Mitchell J Frederick; Kenji Mitsudo; Ying Henderson; Sue E Crawford; Gary A Silverman; Gary L Clayman
Production of serpins using baculovirus expression systems.
Methods (San Diego, Calif.) 2004;32(2):177-84.
2004: Kjell Nustad; Barry Dowell; Gerard J Davis; K Stewart; Olle Nilsson; E Röijer; Yoshinori Suminami; Shugo Nawata; Sule Cataltepe; Gary A Silverman; H Kato; H W A de Bruijn
Characterization of monoclonal antibodies directed against squamous cell carcinoma antigens: report of the TD-10 Workshop.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2004;25(1-2):69-90.
2003: manuela gariboldi; Bernard Peissel; Alessandra Fabbri; Anna Saran; Daniela Zaffaroni; F Stefania Falvella; Monica Spinola; Jun-ichi Tanuma; Simonetta Pazzaglia; Mariateresa Mancuso; Andrea Maurichi; Cesare Bartoli; Sule Cataltepe; Gary A Silverman; Silvana Pilotti; Yoshihide Hayashizaki; Yasushi Okazaki; Tommaso A Dragani
SCCA2-like serpins mediate genetic predisposition to skin tumors.
Cancer research 2003;63(8):1871-5.
2003: Arumugam Jayakumar; Ya'an Kang; Mitchell J Frederick; Stephen C Pak; Ying Henderson; Paula R Holton; Kenji Mitsudo; Gary A Silverman; Adel K El-Naggar; Dieter Brömme; Gary L Clayman
Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis.
Archives of biochemistry and biophysics 2003;409(2):367-74.
2002: James Irving; Robert N Pike; Weiwen Dai; Dieter Brömme; D Margaret Worrall; Gary A Silverman; Theresa H T Coetzer; Clive Dennison; Stephen P Bottomley; James C Whisstock
Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases.
Biochemistry 2002;41(15):4998-5004.
2002: May Al-Khunaizi; Cliff J Luke; Yuko S Askew; Stephen C Pak; David J Askew; Sule Cataltepe; David Miller; David R Mills; Christopher Tsu; Dieter Brömme; James Irving; James C Whisstock; Gary A Silverman
The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases.
Biochemistry 2002;41(9):3189-99.
2002: Ryuji Yasumatsu; Torahiko Nakashima; Yuichiro Kuratomi; Naoya Hirakawa; Kaoru Azuma; Kichinobu Tomita; Sule Cataltepe; Gary A Silverman; Gary L Clayman; Sohtaro Komiyama
Serum squamous cell carcinoma antigen is a useful biologic marker in patients with inverted papillomas of the sinonasal tract.
Cancer 2002;94(1):152-8.
2001: Yuko S Askew; Stephen C Pak; Cliff J Luke; David J Askew; Sule Cataltepe; David R Mills; H Kato; Jessica A Lehoczky; Ken Dewar; Bruce Birren; Gary A Silverman
SERPINB12 is a novel member of the human ov-serpin family that is widely expressed and inhibits trypsin-like serine proteinases.
The Journal of biological chemistry 2001;276(52):49320-30.
2001: Gary A Silverman; Phillip I Bird; Robin W Carrell; Frank Church; Paul B Coughlin; Peter G W Gettins; James Irving; D A Lomas; C J Luke; R W Moyer; Philip A Pemberton; Eileen Remold-O'Donnell; G S Salvesen; J Travis; James C Whisstock
The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature.
The Journal of biological chemistry 2001;276(36):33293-6.
2001: Ryuji Yasumatsu; Torahiko Nakashima; K Azuma; Naoya Hirakawa; Yuichiro Kuratomi; Kichinobu Tomita; Sule Cataltepe; Gary A Silverman; Gary L Clayman; Sohtaro Komiyama
SCCA1 expression in T-lymphocytes peripheral to cancer cells is associated with the elevation of serum SCC antigen in squamous cell carcinoma of the tongue.
Cancer letters 2001;167(2):205-13.
2001: Yoshinori Suminami; S Nagashima; Akihiro Murakami; Shugo Nawata; T Gondo; Hiroshi Hirakawa; Fumitaka Numa; Gary A Silverman; Hiroshi Kato
Suppression of a squamous cell carcinoma (SCC)-related serpin, SCC antigen, inhibits tumor growth with increased intratumor infiltration of natural killer cells.
Cancer research 2001;61(5):1776-80.
2000: T Nakashima; Stephen C Pak; Gary A Silverman; PM Spring; Mitchell J Frederick; Gary L Clayman
Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells.
Biochimica et biophysica acta 2000;1492(2-3):441-6.
2000: Y Uemura; Stephen C Pak; Cliff J Luke; Sule Cataltepe; Christopher Tsu; C Schick; Y Kamachi; S L Pomeroy; D H Perlmutter; Gary A Silverman
Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.
International journal of cancer. Journal international du cancer 2000;89(4):368-77.
2000: Cliff J Luke; C Schick; Christopher Tsu; James C Whisstock; James Irving; Dieter Brömme; L Juliano; Guo-Ping Shi; H A Chapman; Gary A Silverman
Simple modifications of the serpin reactive site loop convert SCCA2 into a cysteine proteinase inhibitor: a critical role for the P3' proline in facilitating RSL cleavage.
Biochemistry 2000;39(24):7081-91.
2000: Sule Cataltepe; C Schick; Cliff J Luke; Stephen C Pak; D Goldfarb; P Chen; M J Tanasiyevic; M R Posner; Gary A Silverman
Development of specific monoclonal antibodies and a sensitive discriminatory immunoassay for the circulating tumor markers SCCA1 and SCCA2.
Clinica chimica acta; international journal of clinical chemistry 2000;295(1-2):107-27.
2000: Angelique Ruzindana-Umunyana; Sucheta Sircar; C Schick; Gary A Silverman; Joseph M Weber
Adenovirus endopeptidase hydrolyses human squamous cell carcinoma antigens in vitro but not ex vivo.
Virology 2000;268(1):141-6.
2000: Sule Cataltepe; ER Gornstein; C Schick; Y Kamachi; K Chatson; J Fries; Gary A Silverman; M P Upton
Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(1):113-22.
1999: S G Katz; S S Schneider; AJ Bartuski; Barbara J Trask; Hillary F Massa; J Overhauser; M Lalande; P M Lansdorp; Gary A Silverman
An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.
Human molecular genetics 1999;8(1):87-92.
1998: AJ Bartuski; Y Kamachi; C Schick; Hillary F Massa; Barbara J Trask; Gary A Silverman
A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases.
Genomics 1998;54(2):297-306.
1998: C Schick; Dieter Brömme; AJ Bartuski; Y Uemura; N M Schechter; Gary A Silverman
The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13465-70.
1998: Sule Cataltepe; C Schick; Gary A Silverman
Preventive therapy for chronic lung disease.
Pediatrics 1998;102(2 Pt 1):438; author reply 439.
1998: W Zeng; Gary A Silverman; Eileen Remold-O'Donnell
Structure and sequence of human M/NEI (monocyte/neutrophil elastase inhibitor), an Ov-serpin family gene.
Gene 1998;213(1-2):179-87.
1998: Smita Thakker-Varia; S Elkabes; C Schick; Gary A Silverman; L Peng; A C Sherwood; Ira B Black
Gene expression in activated brain microglia: identification of a proteinase inhibitor that increases microglial cell number.
Brain research. Molecular brain research 1998;56(1-2):99-107.
1998: C Schick; Philip A Pemberton; Guo-Ping Shi; Y Kamachi; Sule Cataltepe; AJ Bartuski; ER Gornstein; Dieter Brömme; H A Chapman; Gary A Silverman
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.
Biochemistry 1998;37(15):5258-66.
1998: Gary A Silverman; AJ Bartuski; Sule Cataltepe; ER Gornstein; Y Kamachi; C Schick; Y Uemura
SCCA1 and SCCA2 are proteinase inhibitors that map to the serpin cluster at 18q21.3.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1998;19(6):480-7.
1997: AJ Bartuski; Y Kamachi; C Schick; J Overhauser; Gary A Silverman
Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3.
Genomics 1997;43(3):321-8.
1997: C Schick; Y Kamachi; AJ Bartuski; Sule Cataltepe; N M Schechter; Philip A Pemberton; Gary A Silverman
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
The Journal of biological chemistry 1997;272(3):1849-55.
1996: Gary A Silverman; J Overhauser; S Gerken; R Aburomia; Peter O'Connell; K S Krauter; S D Detera-Wadleigh; T Yoshikawa; ANDREW COLLINS; A Geurts van Kessel
Report of the Fourth International Workshop on Human Chromosome 18 Mapping. Boston, Massachusetts, October 7-9, 1996.
Cytogenetics and cell genetics 1996;75(2-3):111-31.
1996: Gary A Silverman
Purification of YAC-containing total yeast DNA.
Methods in molecular biology (Clifton, N.J.) 1996;54():65-8.
1996: Gary A Silverman
Reconstruction of large genomic segments of DNA by meiotic recombination between YACs.
Methods in molecular biology (Clifton, N.J.) 1996;54():199-216.
1996: Gary A Silverman
End-rescue of YAC clone inserts by inverse PCR.
Methods in molecular biology (Clifton, N.J.) 1996;54():145-55.
1995: S S Schneider; C Schick; K E Fish; E Miller; J C Pena; S D Treter; S M Hui; Gary A Silverman
A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3147-51.
1995: Gary A Silverman; S S Schneider; Hillary F Massa; A Flint; Marc Lalande; J C Leonard; J Overhauser; Ger van den Engh; Barbara J Trask
The 18q- syndrome: analysis of chromosomes by bivariate flow karyotyping and the PCR reveals a successive set of deletion breakpoints within 18q21.2-q22.2.
American journal of human genetics 1995;56(4):926-37.
1995: S M Hui; Barbara J Trask; Ger van den Engh; AJ Bartuski; A Smith; A Flint; Marc Lalande; Gary A Silverman
Analysis of randomly amplified flow-sorted chromosomes using the polymerase chain reaction.
Genomics 1995;26(2):364-71.
1995: K Rojas; Gary A Silverman; J R Hudson; J Overhauser
Integration of the 1993-94 Généthon genetic linkage map for chromosome 18 with the physical map using a somatic cell hybrid mapping panel.
Genomics 1995;25(1):329-30.
1995: J Overhauser; Gary A Silverman; S Gerken; A Geurts van Kessel
Report of the Third International Workshop on human chromosome 18 mapping 1995.
Cytogenetics and cell genetics 1995;71(2):106-17.
1994: S Gerken; K Fish; D Uyar; Mihael H Polymeropoulos; P Bradley; Raymond White; J Overhauser; Gary A Silverman
Integration of 28 STSs into the physical map of human chromosome 18.
Genomics 1994;24(3):612-3.
1994: T S Khurana; E C Engle; R R Bennett; Gary A Silverman; S Selig; G A Bruns; Louis Kunkel
(CA) repeat polymorphism in the chromosome 18 encoded dystrophin-like protein.
Human molecular genetics 1994;3(5):841.
1994: E Chang; J Luna; J Giacalone; D Uyar; Gary A Silverman; Uta Francke
Regional localization of 56 new human chromosome 18-specific yeast artificial chromosomes.
Cytogenetics and cell genetics 1994;65(1-2):136-9.
1994: A G van Kessel; R E Straub; Gary A Silverman; S Gerken; J Overhauser
Report and abstracts of the second international workshop on human chromosome 18 mapping. Doorwerth, the Netherlands, July 19-20, 1993.
Cytogenetics and cell genetics 1994;65(3):142-65.
1993: Gary A Silverman
Isolating vector-insert junctions from yeast artificial chromosomes.
PCR methods and applications 1993;3(3):141-50.
1993: Gary A Silverman; E Yang; J H Proffitt; M Zutter; S J Korsmeyer
Genetic transfer and expression of reconstructed yeast artificial chromosomes containing normal and translocated BCL2 proto-oncogenes.
Molecular and cellular biology 1993;13(9):5469-78.
1993: P H Domer; S S Fakharzadeh; C S Chen; J Jockel; L Johansen; Gary A Silverman; J H Kersey; Stanley J Korsmeyer
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(16):7884-8.
1993: K M Lia; G A Bruns; M M LeBeau; Gary A Silverman
pMCT108.2 is a chimaeric clone which physically maps to human chromosome bands 9q33 (D9S203) and 18q21.1 (D18S24).
Human molecular genetics 1993;2(3):332.
1993: Gary A Silverman; R Jenkins; G A Bruns; M M LeBeau
Reassignment of pEFD70.3 (D18S23) to human chromosome band 21q22.2 (D21S412) by physical mapping.
Human molecular genetics 1993;2(3):331.
1993: Gary A Silverman; W L Kuo; P Taillon-Miller; Joe Gray
Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18.
Genomics 1993;15(2):442-5.
1993: J Overhauser; R Mewar; K Rojas; K Lia; ANTONIE KLINE; Gary A Silverman
STS map of genes and anonymous DNA fragments on human chromosome 18 using a panel of somatic cell hybrids.
Genomics 1993;15(2):387-91.
1991: M Zutter; David M Hockenbery; Gary A Silverman; Stanley J Korsmeyer
Immunolocalization of the Bcl-2 protein within hematopoietic neoplasms.
Blood 1991;78(4):1062-8.
1991: Gary A Silverman; J I Jockel; P H Domer; R M Mohr; P Taillon-Miller; Stanley J Korsmeyer
Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2.
Genomics 1991;9(2):219-28.
1990: Gary A Silverman; Eric Green; R L Young; J I Jockel; P H Domer; Stanley J Korsmeyer
Meiotic recombination between yeast artificial chromosomes yields a single clone containing the entire BCL2 protooncogene.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9913-7.