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Richard Silverman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
22
Roman, Linda
15
Martásek, Pavel
12
Ji, Haitao
10
Li, Huiying
10
Lu, Xingliang
10
Poulos, Thomas
8
Martasek, Pavel
8
Gu, Wenxin
6
Gómez-Vidal, José
6
Nikolic, Dejan
6
van Breemen, Richard
5
Zhu, Yaoqiu
5
Seo, Jiwon
5
Hah, Jung-Mi
5
Huang, H

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Publications

TOP 3
Xue Fengtian; Gu Wenxin; Silverman Richard B
Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide.
Silverman Richard B; Lawton Graham R; Ralay Ranaivo Hantamalala; Chico Laura K; Seo Jiwon; Watterson D Martin
Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.
Derrick Matthew; Drobyshevsky Alexander; Ji Xinhai; Chen Lina; Yang Yirong; Ji Haitao; Silverman Richard B; Tan Sidhartha
Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test.

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All Publications

2009: Xue Fengtian; Gu Wenxin; Silverman Richard B
Concise route to the chiral pyrrolidine core of selective inhibitors of neuronal nitric oxide.
Organic letters 2009;11(22):5194-7.
2009: Silverman Richard B; Lawton Graham R; Ralay Ranaivo Hantamalala; Chico Laura K; Seo Jiwon; Watterson D Martin
Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration.
Bioorganic & medicinal chemistry 2009;17(21):7593-605.
2009: Derrick Matthew; Drobyshevsky Alexander; Ji Xinhai; Chen Lina; Yang Yirong; Ji Haitao; Silverman Richard B; Tan Sidhartha
Hypoxia-ischemia causes persistent movement deficits in a perinatal rabbit model of cerebral palsy: assessed by a new swim test.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2009;27(6):549-57.
2009: Fang Jianguo; Ji Haitao; Lawton Graham R; Xue Fengtian; Roman Linda J; Silverman Richard B
L337H mutant of rat neuronal nitric oxide synthase resembles human neuronal nitric oxide synthase toward inhibitors.
Journal of medicinal chemistry 2009;52(14):4533-7.
2009: Fang Jianguo; Silverman Richard B
A cellular model for screening neuronal nitric oxide synthase inhibitors.
Analytical biochemistry 2009;390(1):74-8.
2009: Igarashi Jotaro; Li Huiying; Jamal Joumana; Ji Haitao; Fang Jianguo; Lawton Graham R; Silverman Richard B; Poulos Thomas L
Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.
Journal of medicinal chemistry 2009;52(7):2060-6.
2009: Lawton Graham R; Ralay Ranaivo Hantamalala; Chico Laura K; Ji Haitao; Xue Fengtian; Martásek Pavel; Roman Linda J; Watterson D Martin; Silverman Richard B
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability.
Bioorganic & medicinal chemistry 2009;17(6):2371-80.
2009: Silverman Richard B
Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.
Accounts of chemical research 2009;42(3):439-51.
2009: Ji Haitao; Tan Sidhartha; Igarashi Jotaro; Li Huiying; Derrick Matthew; Martásek Pavel; Roman Linda J; Vásquez-Vivar Jeannette; Poulos Thomas L; Silverman Richard B
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
Annals of neurology 2009;65(2):209-17.
2009: Ji Haitao; Li Huiying; Martásek Pavel; Roman Linda J; Poulos Thomas L; Silverman Richard B
Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.
Journal of medicinal chemistry 2009;52(3):779-97.
2009: Lawton Graham R; Ji Haitao; Martásek Pavel; Roman Linda J; Silverman Richard B
Synthesis and enzymatic evaluation of 2- and 4-aminothiazole-based inhibitors of neuronal nitric oxide synthase.
Beilstein journal of organic chemistry 2009;5():28.
2008: Clift Michael D; Silverman Richard B
Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase.
Bioorganic & medicinal chemistry letters 2008;18(10):3122-5.
2008: Ji Haitao; Stanton Benjamin Z; Igarashi Jotaro; Li Huiying; Martásek Pavel; Roman Linda J; Poulos Thomas L; Silverman Richard B
Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors.
Journal of the American Chemical Society 2008;130(12):3900-14.
2008: Trott Amy; West James D; Klaic Lada; Westerheide Sandy D; Silverman Richard B; Morimoto Richard I; Morano Kevin A
Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.
Molecular biology of the cell 2008;19(3):1104-12.
2008: Zhu Yaoqiu; Silverman Richard B
Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s).
Biochemistry 2008;47(8):2231-43.
2008: Silverman Richard B
From basic science to blockbuster drug: the discovery of Lyrica.
Angewandte Chemie (International ed. in English) 2008;47(19):3500-4.
2007: Clift Michael D; Ji Haitao; Deniau Gildas P; O'Hagan David; Silverman Richard B
Enantiomers of 4-amino-3-fluorobutanoic acid as substrates for gamma-aminobutyric acid aminotransferase. Conformational probes for GABA binding.
Biochemistry 2007;46(48):13819-28.
2007: Erdal Erik P; Martásek Pavel; Roman Linda J; Silverman Richard B
Hydroxyethylene isosteres of selective neuronal nitric oxide synthase inhibitors.
Bioorganic & medicinal chemistry 2007;15(18):6096-108.
2007: Seo Jiwon; Igarashi Jotato; Li Huiying; Martasek Pavel; Roman Linda J; Poulos Thomas L; Silverman Richard B
Structure-based design and synthesis of N(omega)-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
Journal of medicinal chemistry 2007;50(9):2089-99.
2007: Zhu Yaoqiu; Silverman Richard B
Model studies for heme oxygenase-catalyzed porphyrin meso hydroxylation.
Organic letters 2007;9(7):1195-8.
2007: Yuan Hai; Silverman Richard B
Structural modifications of (1S,3S)-3-amino-4-difluoromethylenecyclopentanecarboxylic acid, a potent irreversible inhibitor of GABA aminotransferase.
Bioorganic & medicinal chemistry letters 2007;17(6):1651-4.
2007: Seo Jiwon; Martásek Pavel; Roman Linda J; Silverman Richard B
Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
Bioorganic & medicinal chemistry 2007;15(5):1928-38.
2007: Zhu Yaoqiu; Silverman Richard B
Electronic effects of peripheral substituents at porphyrin meso positions.
The Journal of organic chemistry 2007;72(1):233-9.
2006: Lu Hejun; Silverman Richard B
Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors.
Journal of medicinal chemistry 2006;49(25):7404-12.
2006: Wang Zhiyong; Yuan Hai; Nikolic Dejan; Van Breemen Richard B; Silverman Richard B
(+/-)-(1S,2R,5S)-5-Amino-2-fluorocyclohex-3-enecarboxylic acid. A potent GABA aminotransferase inactivator that irreversibly inhibits via an elimination-aromatization pathway.
Biochemistry 2006;45(48):14513-22.
2006: Ji Haitao; Gómez-Vidal José A; Martasek Pavel; Roman Linda J; Silverman Richard B
Conformationally restricted dipeptide amides as potent and selective neuronal nitric oxide synthase inhibitors.
Journal of medicinal chemistry 2006;49(21):6254-63.
2006: Mbadugha Bessie N A; Seo Jiwon; Ji Haitao; Martásek Pavel; Roman Linda J; Shea Thomas M; Li Huiying; Poulos Thomas L; Silverman Richard B
Hydroxyl-terminated peptidomimetic inhibitors of neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 2006;14(11):3681-90.
2006: Gu Wenxin; Nusinzon Inna; Smith Ronald D; Horvath Curt M; Silverman Richard B
Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases.
Bioorganic & medicinal chemistry 2006;14(10):3320-9.
2006: Litzinger Elizabeth A; Martásek Pavel; Roman Linda J; Silverman Richard B
Design, synthesis, and biological testing of potential heme-coordinating nitric oxide synthase inhibitors.
Bioorganic & medicinal chemistry 2006;14(9):3185-98.
2006: Wang Zhiyong; Silverman Richard B
Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase.
Bioorganic & medicinal chemistry 2006;14(7):2242-52.
2006: Yuan Hai; Silverman Richard B
New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity.
Bioorganic & medicinal chemistry 2006;14(5):1331-8.
2006: Crittenden Deborah L; Park Anna; Qiu Jian; Silverman Richard B; Duke Rujee K; Johnston Graham A R; Jordan Meredith J T; Chebib Mary
Enantiomers of cis-constrained and flexible 2-substituted GABA analogues exert opposite effects at recombinant GABA(C) receptors.
Bioorganic & medicinal chemistry 2006;14(2):447-55.
2005: Li Huiying; Flinspach Mack L; Igarashi Jotaro; Jamal Joumana; Yang Weiping; Gómez-Vidal José Antonio; Litzinger Elizabeth A; Huang Hui; Erdal Erik P; Silverman Richard B; Poulos Thomas L
Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases.
Biochemistry 2005;44(46):15222-9.
2005: Liu Shouxin; Gu Wenxin; Lo Denise; Ding Xian-Zhong; Ujiki Michael; Adrian Thomas E; Soff Gerald A; Silverman Richard B
N-methylsansalvamide a peptide analogues. Potent new antitumor agents.
Journal of medicinal chemistry 2005;48(10):3630-8.
2005: Vintém Ana Paula B; Price Nigel T; Silverman Richard B; Ramsay Rona R
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines.
Bioorganic & medicinal chemistry 2005;13(10):3487-95.
2005: Zhu Yaoqiu; Nikolic Dejan; Van Breemen Richard B; Silverman Richard B
Mechanism of inactivation of inducible nitric oxide synthase by amidines. Irreversible enzyme inactivation without inactivator modification.
Journal of the American Chemical Society 2005;127(3):858-68.
2005: Erdal Erik P; Litzinger Elizabeth A; Seo Jiwon; Zhu Yaoqiu; Ji Haitao; Silverman Richard B
Selective neuronal nitric oxide synthase inhibitors.
Current topics in medicinal chemistry 2005;5(7):603-24.
2004: Westerheide Sandy D; Bosman Joshua D; Mbadugha Bessie N A; Kawahara Tiara L A; Matsumoto Gen; Kim Soojin; Gu Wenxin; Devlin John P; Silverman Richard B; Morimoto Richard I
Celastrols as inducers of the heat shock response and cytoprotection.
The Journal of biological chemistry 2004;279(53):56053-60.
2004: Storici Paola; Qiu Jian; Schirmer Tilman; Silverman Richard B
Mechanistic crystallography. Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1R,3S,4S)-3-amino-4-fluorocyclopentane-1-carboxylic acid as elucidated by crystallography.
Biochemistry 2004;43(44):14057-63.
2004: Pan Yue; Calvert Kristi; Silverman Richard B
Conformationally-restricted vigabatrin analogs as irreversible and reversible inhibitors of gamma-aminobutyric acid aminotransferase.
Bioorganic & medicinal chemistry 2004;12(21):5719-25.
2004: Wang Zhiyong; Silverman Richard B
Synthesis of cyclopropane isosteres of the antiepilepsy drug vigabatrin and evaluation of their inhibition of GABA aminotransferase.
Journal of enzyme inhibition and medicinal chemistry 2004;19(4):293-301.
2004: Schering Christine A; Zhong Boyu; Woo Jonathan C G; Silverman Richard B
Poly(ethylene glycol)-supported enzyme inactivators. Efficient identification of the site of covalent attachment to alpha-chymotrypsin by PEG-TPCK.
Bioconjugate chemistry 2004;15(4):673-6.
2004: Flinspach Mack; Li Huiying; Jamal Joumana; Yang Weiping; Huang Hui; Silverman Richard B; Poulos Thomas L
Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound.
Biochemistry 2004;43(18):5181-7.
2004: Gómez-Vidal José A; Martásek Pavel; Roman Linda J; Silverman Richard B
Potent and selective conformationally restricted neuronal nitric oxide synthase inhibitors.
Journal of medicinal chemistry 2004;47(3):703-10.
2004: Flinspach Mack L; Li Huiying; Jamal Joumana; Yang Weiping; Huang Hui; Hah Jung-Mi; Gómez-Vidal José Antonio; Litzinger Elizabeth A; Silverman Richard B; Poulos Thomas L
Structural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Nature structural & molecular biology 2004;11(1):54-9.
2004: Fu Mengmeng; Silverman Richard B
Inactivation of gamma-aminobutyric acid aminotransferase by (S)-4-amino-4,5-dihydro-2-furancarboxylic acid does not proceed by the expected aromatization mechanism.
Bioorganic & medicinal chemistry letters 2004;14(1):203-6.
2004: Storici Paola; De Biase Daniela; Bossa Francesco; Bruno Stefano; Mozzarelli Andrea; Peneff Caroline; Silverman Richard B; Schirmer Tilman
Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin.
The Journal of biological chemistry 2004;279(1):363-73.
2003: Ji Haitao; Li Huiying; Flinspach Mack; Poulos Thomas L; Silverman Richard B
Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.
Journal of medicinal chemistry 2003;46(26):5700-11.
2003: Pan Yue; Qiu Jian; Silverman Richard B
Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor.
Journal of medicinal chemistry 2003;46(25):5292-3.
2003: Gu Wenxin; Silverman Richard B
Solid-phase total synthesis of scytalidamide A.
The Journal of organic chemistry 2003;68(23):8774-9.
2003: Lu Xingliang; Nikolic Dejan; Mitchell Deanna J; van Breemen Richard B; Mersfelder John A; Hille Russ; Silverman Richard B
A mechanism for substrate-Induced formation of 6-hydroxyflavin mononucleotide catalyzed by C30A trimethylamine dehydrogenase.
Bioorganic & medicinal chemistry letters 2003;13(22):4129-32.
2003: Lu Xingliang; Rodríguez María; Gu Wenxin; Silverman Richard B
Inactivation of mitochondrial monoamine oxidase B by methylthio-substituted benzylamines.
Bioorganic & medicinal chemistry 2003;11(20):4423-30.
2003: Nandi Dhirendra; Lightcap Eric S; Koo Yumee Kim; Lu Xingliang; Quancard Jean; Silverman Richard B
Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.
The international journal of biochemistry & cell biology 2003;35(7):1085-97.
2003: Hah Jung-Mi; Martásek Pavel; Roman Linda J; Silverman Richard B
Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 2003;46(9):1661-9.
2003: Gu Wenxin; Silverman Richard B
New stable backbone linker resins for solid-phase peptide synthesis.
Organic letters 2003;5(4):415-8.
2002: Gu Wenxin; Liu S Shouxin; Silverman Richard B
Solid-phase, Pd-catalyzed silicon-aryl carbon bond formation. Synthesis of sansalvamide A peptide.
Organic letters 2002;4(23):4171-4.
2002: Choi Sun; Silverman Richard B
Inactivation and inhibition of gamma-aminobutyric acid aminotransferase by conformationally restricted vigabatrin analogues.
Journal of medicinal chemistry 2002;45(20):4531-9.
2002: Choi Sun; Storici Paola; Schirmer Tilman; Silverman Richard B
Design of a conformationally restricted analogue of the antiepilepsy drug Vigabatrin that directs its mechanism of inactivation of gamma-aminobutyric acid aminotransferase.
Journal of the American Chemical Society 2002;124(8):1620-4.
2001: Gómez-Vidal J A; Silverman R B
Short, highly efficient syntheses of protected 3-azido- and 4-azidoproline and their precursors.
Organic letters 2001;3(16):2481-4.
2001: Gómez-Vidal J A; Forrester M T; Silverman R B
Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters.
Organic letters 2001;3(16):2477-9.
2001: Hah J M; Roman L J; Martásek P; Silverman R B
Reduced amide bond peptidomimetics. (4S)-N-(4-amino-5-[aminoakyl]aminopentyl)-N'-nitroguanidines, potent and highly selective inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 2001;44(16):2667-70.
2001: Mitchell D J; Nikolic D; Jang M H; van Breemen R B; Hille R; Silverman R B
Inactivation of C30A trimethylamine dehydrogenase by N-cyclopropyl-alpha-methylbenzylamine, 1-phenylcyclopropylamine, and phenylhydrazine.
Biochemistry 2001;40(29):8523-30.
2001: Mitchell D J; Nikolic D; van Breemen R B; Silverman R B
Inactivation of monoamine oxidase B by 1-phenylcyclopropylamine: mass spectral evidence for the flavin adduct.
Bioorganic & medicinal chemistry letters 2001;11(13):1757-60.
2001: Mitchell D J; Nikolic D; Rivera E; Sablin S O; Choi S; van Breemen R B; Singer T P; Silverman R B
Spectrometric evidence for the flavin-1-phenylcyclopropylamine inactivator adduct with monoamine oxidase N.
Biochemistry 2001;40(18):5447-56.
2001: Huang H; Hah J M; Silverman R B
Mechanism of nitric oxide synthase. Evidence that direct hydrogen atom abstraction from the O-H bond of NG-hydroxyarginine is not relevant to the mechanism.
Journal of the American Chemical Society 2001;123(11):2674-6.
2001: Huang H; Martásek P; Roman L J; Silverman R B
Synthesis and evaluation of dipeptide amides containing N omega-nitroarginine and D-2,4-diaminobutyric acids as inhibitors of neuronal nitric oxide synthase.
Journal of enzyme inhibition 2001;16(3):233-9.
2000: Lee Y; Martásek P; Roman L J; Silverman R B
1H-pyrazole-1-carboxamidines: new inhibitors of nitric oxide synthase.
Bioorganic & medicinal chemistry letters 2000;10(24):2771-4.
2000: Lee Y; Silverman R B
Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic sansalvamide A using a side-chain-tethered phenylalanine building block.
Organic letters 2000;2(23):3743-6.
2000: Hah J M; Roman L J; Silverman R B
Deuterium isotope effects and product studies for the oxidation of N(omega)-allyl-L-arginine and N(omega)-allyl-N(omega)-hydroxy-L-arginine by neuronal nitric oxide synthase.
Bioorganic & medicinal chemistry 2000;8(8):1931-6.
2000: Wang X; Silverman R B
Monoamine oxidase-catalyzed oxidation of endo,endo-2-amino-6-[(Z)-2'-phenyl]ethenylbicyclo[2.2.1]heptane, a potential probe for a radical cation intermediate.
Bioorganic & medicinal chemistry 2000;8(7):1645-51.
2000: Huang H; Martásek P; Roman L J; Silverman R B
Synthesis and evaluation of peptidomimetics as selective inhibitors and active site probes of nitric oxide synthases.
Journal of medicinal chemistry 2000;43(15):2938-45.
2000: Lee Y; Silverman R B
Traceless solid-phase synthesis of chiral 3-aryl beta-amino acid containing peptides using a side-chain-tethered beta-amino acid building block.
Organic letters 2000;2(3):303-6.
2000: Qiu J; Silverman R B
A new class of conformationally rigid analogues of 4-amino-5-halopentanoic acids, potent inactivators of gamma-aminobutyric acid aminotransferase.
Journal of medicinal chemistry 2000;43(4):706-20.
2000: Koo Y K; Nandi D; Silverman R B
The multiple active enzyme species of gamma-aminobutyric acid aminotransferase are not isozymes.
Archives of biochemistry and biophysics 2000;374(2):248-54.
2000: Woodroofe C C; Mostashari R; Lu X; Ramsay R R; Silverman R B
Selective inhibition of monoamine oxidase B by aminoethyl substituted benzyl ethers.
Journal of enzyme inhibition 2000;15(1):11-21.
1999: Qiu J; Pingsterhaus J M; Silverman R B
Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase.
Journal of medicinal chemistry 1999;42(22):4725-8.
1999: Chebib M; Johnston G A; Mattsson J P; Rydström K; Nilsson K; Qiu J; Stevenson S H; Silverman R B
Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists.
Bioorganic & medicinal chemistry letters 1999;9(21):3093-8.
1999: Lee Y; Martasek P; Roman L J; Masters B S; Silverman R B
Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases.
Bioorganic & medicinal chemistry 1999;7(9):1941-51.
1999: Johnson T R; Silverman R B
Syntheses of (Z)-and (E)-4-amino-2-(trifluoromethyl)-2-butenoic acid and their inactivation of gamma-aminobutyric acid aminotransferase.
Bioorganic & medicinal chemistry 1999;7(8):1625-36.
1999: Fu M; Silverman R B
Isolation and characterization of the product of inactivation of gamma-aminobutyric acid aminotransferase by gabaculine.
Bioorganic & medicinal chemistry 1999;7(8):1581-90.
1999: Huang H; Martasek P; Roman L J; Masters B S; Silverman R B
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Journal of medicinal chemistry 1999;42(16):3147-53.
1999: Lee Y; Marletta M A; Martasek P; Roman L J; Masters B S; Silverman R B
Conformationally-restricted arginine analogues as alternative substrates and inhibitors of nitric oxide synthases.
Bioorganic & medicinal chemistry 1999;7(6):1097-104.
1999: Tierney D L; Huang H; Martasek P; Masters B S; Silverman R B; Hoffman B M
ENDOR spectroscopic evidence for the position and structure of NG-hydroxy-L-arginine bound to holo-neuronal nitric oxide synthase.
Biochemistry 1999;38(12):3704-10.
1999: Qiu J; Stevenson S H; O'Beirne M J; Silverman R B
2,6-Difluorophenol as a bioisostere of a carboxylic acid: bioisosteric analogues of gamma-aminobutyric acid.
Journal of medicinal chemistry 1999;42(2):329-32.
1998: Zhong B; Lu X; Silverman R B
Syntheses of amino nitrones. Potential intramolecular traps for radical intermediates in monoamine oxidase-catalyzed reactions.
Bioorganic & medicinal chemistry 1998;6(12):2405-19.
1998: Lu X; Silverman R B
Inactivation of monoamine oxidase B by cis- and trans-5-aminomethyl-3-(4-methoxyphenyl)dihydrofuran-2(3H)-ones.
Bioorganic & medicinal chemistry 1998;6(10):1851-6.
1997: Zhang H Q; Fast W; Marletta M A; Martasek P; Silverman R B
Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine.
Journal of medicinal chemistry 1997;40(24):3869-70.
1997: Fast W; Levsky M E; Marletta M A; Silverman R B
N omega-propargyl-L-arginine and N omega-hydroxy-N omega-propargyl-L-arginine are inhibitors, but not inactivators, of neuronal and macrophage nitric oxide synthases.
Bioorganic & medicinal chemistry 1997;5(8):1601-8.
1997: Silverman R B; Huang H; Marletta M A; Martasek P
Selective inhibition of neuronal nitric oxide synthase by N omega-nitroarginine-and phenylalanine-containing dipeptides and dipeptide esters.
Journal of medicinal chemistry 1997;40(18):2813-7.
1997: Silverman R B
Oxazolidinones, dihydrofuranones, and pyrrolidinones as inactivators and substrates of monoamine oxidase B: approaches to the design of antiparkinsonian agents.
Farmaco (Società chimica italiana : 1989) 1997;52(5):343-52.
1997: Zhou J J; Li J; Upadhyaya S; Eaton P E; Silverman R B
4-substituted cubylcarbinylamines: a new class of mechanism-based monoamine oxidase B inactivators.
Journal of medicinal chemistry 1997;40(7):1165-8.
1997: Silverman R B; Lu X; Blomquist G D; Ding C Z; Yang S
Inactivation of monoamine oxidase B by benzyl 1-(aminomethyl) cyclopropane-1-carboxylate.
Bioorganic & medicinal chemistry 1997;5(2):297-304.
1996: Silverman R B; Roscher C L
Mechanism-based inactivation of gamma-aminobutyric acid aminotransferase by 3-amino-4-fluorobutanoic acid.
Bioorganic & medicinal chemistry 1996;4(9):1521-35.
1996: DeRose V J; Woo J C; Hawe W P; Hoffman B M; Silverman R B; Yelekci K
Observation of a flavin semiquinone in the resting state of monoamine oxidase B by electron paramagnetic resonance and electron nuclear double resonance spectroscopy.
Biochemistry 1996;35(34):11085-91.
1996: Zhou J J; Zhong B; Silverman R B
Direct continuous fluorometric assay for monoamine oxidase B.
Analytical biochemistry 1996;234(1):9-12.
1996: Lightcap E S; Silverman R B
Slow-binding inhibition of gamma-aminobutyric acid aminotransferase by hydrazine analogues.
Journal of medicinal chemistry 1996;39(3):686-94.
1995: Lightcap E S; Hopkins M H; Olson G T; Silverman R B
Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine.
Bioorganic & medicinal chemistry 1995;3(5):579-85.
1995: Silverman R B; Olson G T
Inactivation of gamma-aminobutyric acid aminotransferase by L-3-chloroalanine hydroxamate.
Bioorganic & medicinal chemistry 1995;3(1):11-8.
1995: Silverman R B; Hawe W P
SAR studies of fluorine-substituted benzylamines and substituted 2-phenylethylamines as substrates and inactivators of monoamine oxidase B.
Journal of enzyme inhibition 1995;9(3):203-15.
1995: Silverman R B
Radical thoughts about the life of MAO.
Progress in brain research 1995;106():23-31.
1994: Woo J C; Silverman R B
Observation of two different chromophores in the resting state of monoamine oxidase B by fluorescence spectroscopy.
Biochemical and biophysical research communications 1994;202(3):1574-8.
1993: Annan N; Silverman R B
New analogues of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators.
Journal of medicinal chemistry 1993;36(24):3968-70.
1993: Ding C Z; Silverman R B
Transformation of heterocyclic reversible monoamine oxidase-B inactivators into irreversible inactivators by N-methylation.
Journal of medicinal chemistry 1993;36(23):3606-10.
1993: Silverman R B; Tran N; Sinha R K; Neuhaus F C
The oxazolidinone antibacterial agent DuP 105 does not act on cell wall biosynthesis or on a beta-lactamase.
Biochemical and biophysical research communications 1993;195(2):1077-80.
1993: Ding C Z; Lu X; Nishimura K; Silverman R B
Transformation of monoamine oxidase-B primary amine substrates into time-dependent inhibitors. Tertiary amine homologues of primary amine substrates.
Journal of medicinal chemistry 1993;36(12):1711-5.
1993: Nishimura K; Lu X; Silverman R B
Inactivation of monoamine oxidase B by analogues of the anticonvulsant agent milacemide (2-(n-pentylamino)acetamide).
Journal of medicinal chemistry 1993;36(4):446-8.
1993: Lu X; Silverman R B
The anti-ulcer drug ranitidine hydrochloride and its synthetic intermediates are inactivators of monoamine oxidase-B.
Journal of enzyme inhibition 1993;7(1):43-5.
1992: Taylor C P; Vartanian M G; Andruszkiewicz R; Silverman R B
3-alkyl GABA and 3-alkylglutamic acid analogues: two new classes of anticonvulsant agents.
Epilepsy research 1992;11(2):103-10.
1992: Ding Z; Silverman R B
5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a new class of monoamine oxidase-B inactivators.
Journal of medicinal chemistry 1992;35(5):885-9.
1992: Ding C Z; Silverman R B
4-(Aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase B inactivators.
Journal of enzyme inhibition 1992;6(3):223-31.
1992: Hopkins M H; Bichler K A; Su T; Chamberlain C L; Silverman R B
Inactivation of gamma-aminobutyric acid aminotransferase by various amine buffers.
Journal of enzyme inhibition 1992;6(3):195-9.
1992: Hopkins M H; Silverman R B
Beta-lactams: a new class of conformationally-rigid inhibitors of gamma-aminobutyric acid aminotransferase.
Journal of enzyme inhibition 1992;6(2):125-9.
1991: Silverman R B; Andruszkiewicz R; Nanavati S M; Taylor C P; Vartanian M G
3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase.
Journal of medicinal chemistry 1991;34(7):2295-8.
1991: Silverman R B
The use of mechanism-based inactivators to probe the mechanism of monoamine oxidase.
Biochemical Society transactions 1991;19(1):201-6.
1991: Burke J R; Silverman R B
4-(Oxoalkyl)-substituted GABA analogues as inactivators and substrates of GABA aminotransferase.
Journal of enzyme inhibition 1991;5(3):199-205.
1990: Andruszkiewicz R; Silverman R B
4-Amino-3-alkylbutanoic acids as substrates for gamma-aminobutyric acid aminotransferase.
The Journal of biological chemistry 1990;265(36):22288-91.
1990: Ryall R P; Nandi D L; Silverman R B
Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase.
Journal of medicinal chemistry 1990;33(6):1790-7.
1990: Silverman R B; Nanavati S M
Selective inhibition of gamma-aminobutyric acid aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids.
Journal of medicinal chemistry 1990;33(3):931-6.
1990: Silverman R B; Nandi D L
Effect of N-ethylmaleimide on beef and rat liver vitamin K1 epoxide reductase.
Journal of enzyme inhibition 1990;3(4):289-94.
1989: Hiebert C K; Sayre L M; Silverman R B
Inactivation of monoamine oxidase by 3,3-dimethyl analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-dihydropyridinium ion. Dramatic effect of beta-mercaptoethanol on substrate turnover and enzyme inactivation.
The Journal of biological chemistry 1989;264(36):21516-21.
1989: Nanavati S M; Silverman R B
Design of potential anticonvulsant agents: mechanistic classification of GABA aminotransferase inactivators.
Journal of medicinal chemistry 1989;32(11):2413-21.
1989: Silverman R B; Oliver J S
2-(Fluoromethyl)-3-phytyl-1,4-naphthoquinone and its 2,3-epoxide. Inhibition of vitamin K epoxide reductase.
Journal of medicinal chemistry 1989;32(9):2138-41.
1988: Silverman R B; Hiebert C K
Inactivation of monoamine oxidase A by the monoamine oxidase B inactivators 1-phenylcyclopropylamine, 1-benzylcyclopropylamine, and N-cyclopropyl-alpha-methylbenzylamine.
Biochemistry 1988;27(22):8448-53.
1988: Silverman R B; Nandi D L
Reduced thioredoxin: a possible physiological cofactor for vitamin K epoxide reductase. Further support for an active site disulfide.
Biochemical and biophysical research communications 1988;155(3):1248-54.
1988: Hiebert C K; Silverman R B
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogues. Inactivation of monoamine oxidase by conformationally rigid analogues of N,N-dimethylcinnamylamine.
Journal of medicinal chemistry 1988;31(8):1566-70.
1988: Silverman R B; George C
Inactivation of gamma-aminobutyric acid aminotransferase by (Z)-4-amino-2-fluorobut-2-enoic acid.
Biochemistry 1988;27(9):3285-9.
1988: Silverman R B; George C
Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (S,E)-4-amino-5-fluoropent-2-enoic acid.
Biochemical and biophysical research communications 1988;150(3):942-6.
1985: Vazquez M L; Silverman R B
Revised mechanism for inactivation of mitochondrial monoamine oxidase by N-cyclopropylbenzylamine.
Biochemistry 1985;24(23):6538-43.
1985: Silverman R B; Hiebert C K; Vazquez M L
Inactivation of monoamine oxidase by allylamine does not result in flavin attachment.
The Journal of biological chemistry 1985;260(27):14648-52.

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