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Robert Silverman

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Deanna Lee; Ka-Cheung Luk; Ross Molinaro; Xiaoxing Qiu; Gerald Schochetman; Robert H Silverman; Graham Simmons; Imke Steffen; Ning Tang; Anatoly Urisman; Jaydip Das Gupta; Joe L DeRisi; Nicole Fischer; Don Ganem; Christina Gaughan; John Hackett; Eric A Klein; Miranda Broz; Charles Y Chiu
In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.
Jaydip Das Gupta; Christina Gaughan; John Hackett; Eugene S Kandel; Eric A Klein; Ka-Cheung Luk; Ning Tang; Robert H Silverman
Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.
Alice Rusmevichientong; Robert H Silverman; Jaydip Das Gupta; Petra S Elias; Samson A Chow
Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus.

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2012: Deanna Lee; Ka-Cheung Luk; Ross Molinaro; Xiaoxing Qiu; Gerald Schochetman; Robert H Silverman; Graham Simmons; Imke Steffen; Ning Tang; Anatoly Urisman; Jaydip Das Gupta; Joe L DeRisi; Nicole Fischer; Don Ganem; Christina Gaughan; John Hackett; Eric A Klein; Miranda Broz; Charles Y Chiu
In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.
PloS one 2012;7(9):e44954.
2012: Jaydip Das Gupta; Christina Gaughan; John Hackett; Eugene S Kandel; Eric A Klein; Ka-Cheung Luk; Ning Tang; Robert H Silverman
Absence of XMRV and closely related viruses in primary prostate cancer tissues used to derive the XMRV-infected cell line 22Rv1.
PloS one 2012;7(5):e36072.
2011: Alice Rusmevichientong; Robert H Silverman; Jaydip Das Gupta; Petra S Elias; Samson A Chow
Analysis of single-nucleotide polymorphisms in patient-derived retrovirus integration sites reveals contamination from cell lines acutely infected by xenotropic murine leukemia virus-related virus.
Journal of virology 2011;85(23):12830-4.
2011: Bart R Anderson; Babal Kant Jha; Hiromi Muramatsu; Robert H Silverman; Drew Weissman; Katalin Karikó
Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L.
Nucleic acids research 2011;39(21):9329-38.
2011: H Elbahesh; Babal Kant Jha; Robert H Silverman; Svetlana V Scherbik; Margo A Brinton
The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells.
Virology 2011;409(2):262-70.
2011: David E Kang; Eric A Klein; Michael C Lee; Jaydip Das Gupta; Robert H Silverman
XMRV Discovery and Prostate Cancer-Related Research.
Advances in virology 2011;2011():432837.
2011: Arindam Chakrabarti; Babal Kant Jha; Robert H Silverman
New insights into the role of RNase L in innate immunity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2011;31(1):49-57.
2010: Robert H Silverman; Carvell Nguyen; Christopher J Weight; Eric A Klein
The human retrovirus XMRV in prostate cancer and chronic fatigue syndrome.
Nature reviews. Urology 2010;7(7):392-402.
2010: Beihua Dong; Robert H Silverman
Androgen stimulates transcription and replication of xenotropic murine leukemia virus-related virus.
Journal of virology 2010;84(3):1648-51.
2010: Sanggu Kim; Alice Rusmevichientong; Beihua Dong; Roland Remenyi; Robert H Silverman; Samson A Chow
Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.
PloS one 2010;5(4):e10255.
2009: Derek D C Ireland; Stephen A Stohlman; David R Hinton; Parul Kapil; Robert H Silverman; Roscoe A Atkinson; Cornelia C Bergmann
RNase L mediated protection from virus induced demyelination.
PLoS pathogens 2009;5(10):e1000602.
2009: Seunghee Hong; Eric A Klein; Jaydip Das Gupta; Kirsten Hanke; Christopher J Weight; Carvell Nguyen; Christina Gaughan; Kyeong-Ae Kim; Norbert Bannert; Frank Kirchhoff; Jan Munch; Robert H Silverman
Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.
Journal of virology 2009;83(14):6995-7003.
2008: Hannah L Townsend; Babal Kant Jha; Robert H Silverman; David J Barton
A putative loop E motif and an H-H kissing loop interaction are conserved and functional features in a group C enterovirus RNA that inhibits ribonuclease L.
RNA biology 2008;5(4):263-72.
2008: Sanggu Kim; Namshin Kim; Beihua Dong; David Boren; Serena A Lee; Jaydip Das Gupta; Christina Gaughan; Eric A Klein; Christopher Lee; Robert H Silverman; Samson A Chow
Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.
Journal of virology 2008;82(20):9964-77.
2008: Arindam Chakrabarti; Anthony J Sadler; Niladri Kar; Howard A Young; Robert H Silverman; Bryan R G Williams
Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA.
The Journal of biological chemistry 2008;283(37):25132-9.
2008: Hannah L Townsend; Babal Kant Jha; Jian-Qiu Han; N Karl Maluf; Robert H Silverman; David J Barton
A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L.
RNA (New York, N.Y.) 2008;14(6):1026-36.
2008: Hongxia Mao; Chandar S Thakur; Santanu Chattopadhyay; Robert H Silverman; Andrei Gudkov; Amiya Banerja
Inhibition of human parainfluenza virus type 3 infection by novel small molecules.
Antiviral research 2008;77(2):83-94.
2008: Beihua Dong; Robert H Silverman; Eugene S Kandel
A natural human retrovirus efficiently complements vectors based on murine leukemia virus.
PloS one 2008;3(9):e3144.
2007: Ernest C Borden; Ganes C Sen; Gilles Uze; Robert H Silverman; Richard M Ransohoff; Graham R Foster; George R Stark
Interferons at age 50: past, current and future impact on biomedicine.
Nature reviews. Drug discovery 2007;6(12):975-90.
2007: Robert H Silverman
Viral encounters with 2',5'-oligoadenylate synthetase and RNase L during the interferon antiviral response.
Journal of virology 2007;81(23):12720-9.
2007: Christopher L Washenberger; Jian-Qiu Han; Katherina J Kechris; Babal Kant Jha; Robert H Silverman; David J Barton
Hepatitis C virus RNA: dinucleotide frequencies and cleavage by RNase L.
Virus research 2007;130(1-2):85-95.
2007: Robert H Silverman
A scientific journey through the 2-5A/RNase L system.
Cytokine & growth factor reviews 2007;18(5-6):381-8.
2007: Krishnamurthy Malathi; Beihua Dong; Michael Gale; Robert H Silverman
Small self-RNA generated by RNase L amplifies antiviral innate immunity.
Nature 2007;448(7155):816-9.
2007: Chandar S Thakur; Babal Kant Jha; Beihua Dong; Jaydip Das Gupta; Kenneth M Silverman; Hongxia Mao; Hiro Sawai; Akiko O Nakamura; Amiya K Banerjee; Andrei Gudkov; Robert H Silverman
Small-molecule activators of RNase L with broad-spectrum antiviral activity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(23):9585-90.
2007: Jian-Qiu Han; Hannah L Townsend; Babal Kant Jha; Jayashree M Paranjape; Robert H Silverman; David J Barton
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Journal of virology 2007;81(11):5561-72.
2007: Beihua Dong; Sanggu Kim; Seunghee Hong; Jaydip Das Gupta; Krishnamurthy Malathi; Eric A Klein; Don Ganem; Joe L DeRisi; Samson A Chow; Robert H Silverman
An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1655-60.
2007: Hagen Cramer; James R Okicki; Taikyun Rho; Xinning Wang; Robert H Silverman; Warren D W Heston
2-5A ligands--a new concept for the treatment of prostate cancer.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1471-7.
2006: Longhu Zhou; Chandar S Thakur; Ross J Molinaro; Jayashree M Paranjape; Rieuwert Hoppes; Kuan-Teh Jeang; Robert H Silverman; Paul F Torrence
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat.
Bioorganic & medicinal chemistry 2006;14(23):7862-74.
2006: Anatoly Urisman; Ross J Molinaro; Nicole Fischer; Sarah J Plummer; Graham Casey; Eric A Klein; Krishnamurthy Malathi; Cristina Magi-Galluzzi; Raymond R Tubbs; Don Ganem; Robert H Silverman; Joe L DeRisi
Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant.
PLoS pathogens 2006;2(3):e25.
2006: Svetlana V Scherbik; Jayashree M Paranjape; Bronislava M Stockman; Robert H Silverman; Margo A Brinton
RNase L plays a role in the antiviral response to West Nile virus.
Journal of virology 2006;80(6):2987-99.
2006: Ross J Molinaro; Babal Kant Jha; Krishnamurthy Malathi; Sooryanarayana Lnu; Arul M Chinnaiyan; Robert H Silverman
Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.
Nucleic acids research 2006;34(22):6684-95.
2006: Jayashree M Paranjape; Da Xu; David M Kushner; James R Okicki; Daniel J Lindner; Hagen Cramer; Robert H Silverman; Douglas W Leaman
Human telomerase RNA degradation by 2'-5'-linked oligoadenylate antisense chimeras in a cell-free system, cultured tumor cells, and murine xenograft models.
Oligonucleotides 2006;16(3):225-38.
2005: Krishnamurthy Malathi; Jayashree M Paranjape; Elena Bulanova; Minsub Shim; Jeanna M Guenther-Johnson; Pieter W Faber; Thomas E Eling; Bryan R G Williams; Robert H Silverman
A transcriptional signaling pathway in the IFN system mediated by 2'-5'-oligoadenylate activation of RNase L.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(41):14533-8.
2005: Aimin Zhou; Ross J Molinaro; Krishnamurthy Malathi; Robert H Silverman
Mapping of the human RNASEL promoter and expression in cancer and normal cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(10):595-603.
2005: Joao T Marques; Dominique Rebouillat; chilakamarti ramana; Junko Murakami; Jason E Hill; Andrei Gudkov; Robert H Silverman; George R Stark; Bryan R G Williams
Down-regulation of p53 by double-stranded RNA modulates the antiviral response.
Journal of virology 2005;79(17):11105-14.
2005: Longhu Zhou; Edgar R Civitello; Nidhi Gupta; Robert H Silverman; Ross J Molinaro; David E Anderson; Paul F Torrence
Endowing RNase H-inactive antisense with catalytic activity: 2-5A-morphants.
Bioconjugate chemistry 2005;16(2):383-90.
2005: Chandar S Thakur; Zan Xu; Zhengfu Wang; Zachary Novince; Robert H Silverman
A convenient and sensitive fluorescence resonance energy transfer assay for RNase L and 2',5' oligoadenylates.
Methods in molecular medicine 2005;116():103-13.
2004: Krishnamurthy Malathi; Jayashree M Paranjape; Ram Ganapathi; Robert H Silverman
HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand.
Cancer research 2004;64(24):9144-51.
2004: Jian-Qiu Han; Gerggory Wroblewski; Zan Xu; Robert H Silverman; David J Barton
Sensitivity of hepatitis C virus RNA to the antiviral enzyme ribonuclease L is determined by a subset of efficient cleavage sites.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2004;24(11):664-76.
2004: Beihua Dong; Quansheng Zhou; Ji Zhao; Aimin Zhou; Ronald N Harty; Santanu Bose; Amiya Banerjee; Roger Slee; Jeanna Guenther; Bryan R G Williams; Therese Wiedmer; Peter J Sims; Robert H Silverman
Phospholipid scramblase 1 potentiates the antiviral activity of interferon.
Journal of virology 2004;78(17):8983-93.
2003: Ying Xiang; Zhengfu Wang; Junko Murakami; Sarah J Plummer; Eric A Klein; John D Carpten; Jeffrey M. Trent; William B Isaacs; Graham Casey; Robert H Silverman
Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates.
Cancer research 2003;63(20):6795-801.
2003: Barbara I Chase; Yan Zhou; Ying Xiang; Robert H Silverman; Aimin Zhou
Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003;23(10):565-73.
2003: Carol A Sledz; Michelle Holko; Michael J de Veer; Robert H Silverman; Bryan R G Williams
Activation of the interferon system by short-interfering RNAs.
Nature cell biology 2003;5(9):834-9.
2003: Khalid S A Khabar; Yunus M Siddiqui; Fahad Al-Zoghaibi; Latifa al-Haj; Mohammed Dhalla; Aimin Zhou; Beihua Dong; Mark Whitmore; Jayashree Paranjape; Mohammed N Al-Ahdal; Futwan Al-Mohanna; Bryan R G Williams; Robert H Silverman
RNase L mediates transient control of the interferon response through modulation of the double-stranded RNA-dependent protein kinase PKR.
The Journal of biological chemistry 2003;278(22):20124-32.
2003: Robert H Silverman
Implications for RNase L in prostate cancer biology.
Biochemistry 2003;42(7):1805-12.
2003: Wolfgang W Leitner; Leroy N Hwang; Michael J deVeer; Aimin Zhou; Robert H Silverman; Bryan R G Williams; Thomas W Dubensky; Han Ying; Nicholas P Restifo
Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways.
Nature medicine 2003;9(1):33-9.
2002: Graham Casey; Phillippa J Neville; Sarah J Plummer; Ying Xiang; Lisa M Krumroy; Eric A Klein; William J Catalona; Nina N Nupponen; John D Carpten; Jeffrey M. Trent; Robert H Silverman; John S Witte
RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases.
Nature genetics 2002;32(4):581-3.
2002: Ying Xiang; Richard C Condit; Sangeetha Vijaysri; Bertram L Jacobs; Bryan R G Williams; Robert H Silverman
Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.
Journal of virology 2002;76(10):5251-9.
2002: Luca G Guidotti; Amber Morris; Heike Mendez; Rick Koch; Robert H Silverman; Bryan R G Williams; Francis V Chisari
Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice.
Journal of virology 2002;76(6):2617-21.
2002: Robert H Silverman; Ammar Halloum; Aimin Zhou; Beihua Dong; Fahad Al-Zoghaibi; David M Kushner; Quansheng Zhou; Ji Zhao; Therese Wiedmer; Peter J Sims
Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.
Cancer research 2002;62(2):397-402.
2002: Douglas W Leaman; Frank J Longano; James R Okicki; Kenneth F Soike; Paul F Torrence; Robert H Silverman; Hagen Cramer
Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense.
Virology 2002;292(1):70-7.
2002: Robert H Silverman; Aimin Zhou; Michael B Auerbach; Danielle D Kish; Anton V Gorbachev; Robert L Fairchild
Skin allograft rejection is suppressed in mice lacking the antiviral enzyme, 2',5'-oligoadenylate-dependent RNase L.
Viral immunology 2002;15(1):77-83.
2001: S A Adah; Suzanne F Bayly; H Cramer; Robert H Silverman; Paul F Torrence
Chemistry and biochemistry of 2',5'-oligoadenylate-based antisense strategy.
Current medicinal chemistry 2001;8(10):1189-212.
2001: Michael J de Veer; Michelle Holko; Mathias Frevel; E Walker; Sandy Der; Jayashree M Paranjape; Robert H Silverman; Bryan R G Williams
Functional classification of interferon-stimulated genes identified using microarrays.
Journal of leukocyte biology 2001;69(6):912-20.
2001: A Deb; S Jaharul Haque; T Mogensen; Robert H Silverman; Bryan R G Williams
RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(10):6170-80.
2001: Beihua Dong; Maho Niwa; Peter Walter; Robert H Silverman
Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p.
RNA (New York, N.Y.) 2001;7(3):361-73.
2001: L Rusch; Beihua Dong; Robert H Silverman
Monitoring activation of ribonuclease L by 2',5'-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells.
Methods in enzymology 2001;342():10-20.
2000: L Rusch; Aimin Zhou; Robert H Silverman
Caspase-dependent apoptosis by 2',5'-oligoadenylate activation of RNase L is enhanced by IFN-beta.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(12):1091-100.
2000: Aimin Zhou; H Nie; Robert H Silverman
Analysis and origins of the human and mouse RNase L genes: mediators of interferon action.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(11):989-92.
2000: Khalid S A Khabar; Mohammed Dhalla; Yunus M Siddiqui; Aimin Zhou; Mohammed N Al-Ahdal; Sandy Der; Robert H Silverman; Bryan R G Williams
Effect of deficiency of the double-stranded RNA-dependent protein kinase, PKR, on antiviral resistance in the presence or absence of ribonuclease L: HSV-1 replication is particularly sensitive to deficiency of the major IFN-mediated enzymes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2000;20(7):653-9.
2000: Quansheng Zhou; Ji Zhao; Fahad Al-Zoghaibi; Aimin Zhou; Therese Wiedmer; Robert H Silverman; Peter J Sims
Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha.
Blood 2000;95(8):2593-9.
2000: David M Kushner; Jayashree M Paranjape; B Bandyopadhyay; Hagen Cramer; Douglas W Leaman; Alexander W Kennedy; Robert H Silverman; John Kenneth Cowell
2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells.
Gynecologic oncology 2000;76(2):183-92.
2000: David M Kushner; Robert H Silverman
Antisense cancer therapy: the state of the science.
Current oncology reports 2000;2(1):23-30.
2000: Robert H Silverman; Beihua Dong; Ratan Maitra; MR Player; Paul F Torrence
Selective RNA cleavage by isolated RNase L activated with 2-5A antisense chimeric oligonucleotides.
Methods in enzymology 2000;313():522-33.
1999: Fulvia Terenzi; Michael J deVeer; H Ying; Nicholas P Restifo; Bryan R G Williams; Robert H Silverman
The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors.
Nucleic acids research 1999;27(22):4369-75.
1999: Aimin Zhou; Jayashree M Paranjape; Sandy Der; Bryan R G Williams; Robert H Silverman
Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways.
Virology 1999;258(2):435-40.
1999: Beihua Dong; Robert H Silverman
Alternative function of a protein kinase homology domain in 2', 5'-oligoadenylate dependent RNase L.
Nucleic acids research 1999;27(2):439-45.
1998: Sandy Der; Aimin Zhou; Bryan R G Williams; Robert H Silverman
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15623-8.
1998: A Maran; C F Waller; Jayashree M Paranjape; G Li; W Xiao; K Zhang; Matt Kalaycio; Ratan Maitra; Alan E Lichtin; W Brugger; Paul F Torrence; Robert H Silverman
2',5'-Oligoadenylate-antisense chimeras cause RNase L to selectively degrade bcr/abl mRNA in chronic myelogenous leukemia cells.
Blood 1998;92(11):4336-43.
1998: Aimin Zhou; Jayashree M Paranjape; Bret A Hassel; H Nie; S Shah; B Galinski; Robert H Silverman
Impact of RNase L overexpression on viral and cellular growth and death.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(11):953-61.
1998: MR Player; Ratan Maitra; Robert H Silverman; Paul F Torrence
Targeting RNase L to human immunodeficiency virus RNA with 2-5A-antisense.
Antiviral chemistry & chemotherapy 1998;9(3):225-31.
1998: W Xiao; G Li; MR Player; Ratan Maitra; C F Waller; Robert H Silverman; Paul F Torrence
Nuclease-resistant composite 2',5'-oligoadenylate-3', 5'-oligonucleotides for the targeted destruction of RNA: 2-5A-iso-antisense.
Journal of medicinal chemistry 1998;41(9):1531-9.
1998: JC Castelli; Bret A Hassel; A Maran; Jayashree M Paranjape; J A Hewitt; Xiao-Ling Li; Yi-Te Hsu; Robert H Silverman; Richard J Youle
The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis.
Cell death and differentiation 1998;5(4):313-20.
1998: S Naik; Jayashree M Paranjape; Robert H Silverman
RNase L dimerization in a mammalian two-hybrid system in response to 2',5'-oligoadenylates.
Nucleic acids research 1998;26(6):1522-7.
1998: Bryan R G Williams; Robert H Silverman
Progress in interferon and cytokine biology.
Cytokine & growth factor reviews 1998;9(1):85-7.
1998: Ratan Maitra; Robert H Silverman
Regulation of human immunodeficiency virus replication by 2',5'-oligoadenylate-dependent RNase L.
Journal of virology 1998;72(2):1146-52.
1997: Aimin Zhou; Jayashree M Paranjape; T L Brown; H Nie; S Naik; Beihua Dong; A Chang; B Trapp; Robert L Fairchild; Clemencia Colmenares; Robert H Silverman
Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L.
The EMBO journal 1997;16(21):6355-63.
1997: Beihua Dong; Robert H Silverman
A bipartite model of 2-5A-dependent RNase L.
The Journal of biological chemistry 1997;272(35):22236-42.
1997: Paul F Torrence; W Xiao; G Li; H Cramer; MR Player; Robert H Silverman
Recruiting the 2-5A system for antisense therapeutics.
Antisense & nucleic acid drug development 1997;7(3):203-6.
1997: W Xiao; G Li; Ratan Maitra; A Maran; Robert H Silverman; Paul F Torrence
Correlation of selective modifications to a 2',5'-oligoadenylate-3',5'-deoxyribonucleotide antisense chimera with affinity for the target nucleic acid and with ability to activate RNase L.
Journal of medicinal chemistry 1997;40(8):1195-200.
1997: N M Cirino; G Li; W Xiao; Paul F Torrence; Robert H Silverman
Targeting RNA decay with 2',5' oligoadenylate-antisense in respiratory syncytial virus-infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(5):1937-42.
1995: L Wang; Aimin Zhou; Sandip P Vasavada; Beihua Dong; H Nie; James M Church; Bryan R G Williams; S Banerjee; Robert H Silverman
Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(11):1421-8.
1995: Leonid Beigelman; Jasenka Matulic-Adamic; P Haeberli; N Usman; B Dong; Robert H Silverman; S Khamnei; Paul F Torrence
Synthesis and biological activities of a phosphorodithioate analog of 2',5'-oligoadenylate.
Nucleic acids research 1995;23(19):3989-94.
1995: Ratan Maitra; G Li; W Xiao; Beihua Dong; Paul F Torrence; Robert H Silverman
Catalytic cleavage of an RNA target by 2-5A antisense and RNase L.
The Journal of biological chemistry 1995;270(25):15071-5.
1995: Beihua Dong; Robert H Silverman
2-5A-dependent RNase molecules dimerize during activation by 2-5A.
The Journal of biological chemistry 1995;270(8):4133-7.
1994: Ratan Maitra; N A McMillan; S Desai; J McSwiggen; A G Hovanessian; G Sen; Bryan R G Williams; Robert H Silverman
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.
Virology 1994;204(2):823-7.
1994: A Maran; Ratan Maitra; A Kumar; Beihua Dong; W Xiao; G Li; Bryan R G Williams; Paul F Torrence; Robert H Silverman
Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras.
Science (New York, N.Y.) 1994;265(5173):789-92.
1994: Robert H Silverman
Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action.
Journal of interferon research 1994;14(3):101-4.
1994: Beihua Dong; L Xu; Aimin Zhou; Bret A Hassel; Xavier Lee; Paul F Torrence; Robert H Silverman
Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase.
The Journal of biological chemistry 1994;269(19):14153-8.
1994: Jeremy Squire; Aimin Zhou; Bret A Hassel; H Nie; Robert H Silverman
Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25.
Genomics 1994;19(1):174-5.
1993: Bret A Hassel; Aimin Zhou; C Sotomayor; A Maran; Robert H Silverman
A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.
The EMBO journal 1993;12(8):3297-304.
1993: Aimin Zhou; Bret A Hassel; Robert H Silverman
Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action.
Cell 1993;72(5):753-65.
1993: Paul F Torrence; Ratan Maitra; K Lesiak; S Khamnei; A Zhou; Robert H Silverman
Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1300-4.